CROHN’S DISEASESTJEPAN ĆURIĆMentor: A. Žmegač Horvat

Dr. Burrill Bernard Crohn

in 1932 he described a series of patients with inflammation of the terminal ileum, the area most commonly affected by the illness

What is Crohn’s?

inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from mouth to anus

Symptoms

abdominal pain diarrhea (which may be bloody) vomiting weight loss skin rashes arthritis inflammation of the eye

Causes

genetics (mutations in CARD15)

environmental factors

immune system

microbes (Mycobacterium avium subspecies paratuberculosis)

endoscopy radiologic tests blood tests comparison with ulcerative colitis

Diagnosis

Treatment

medication (corticosteroids, 5-aminosalicyilic acid, azathioprine, mercaptopurine, methotrexate, infliximab)

lifestyle changes (hydration)

surgery

References:

Mayo Clinic: Crohn's Disease

National Digestive Diseases Information Clearinghouse

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