DPI 1

Dry powder Inhalers

SUBODH S SATHEESH2ND MPHARM

DEPT OF PHARMACEUTICSECPS

Department of pharmaceutics

DPI 2

Introduction COPDPulmonary dosage formsInhaler technologyPMDIDry powder inhalers

DPI 3

Ideal charactersEasy to useMultiple dosesMoistureAccurate and uniformConsistentMinimize adhesion

DPI 4

Design Capsule opening mechanismAirflowRetention of capsule debrisMouthpiece design

DPI 5

Issues with designSingle dose devicesMultiple dose devices

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Mechanism ImpactionDiffusionSedimentationInterceptionElectrostatic precipitation

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Drug deliveryInvitroInvivo

DPI 8

Inhalation devicesNebulizersPressurized metered dose inhalersDry powder inhalers

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Factors affecting DPI devicesHumidityInterparticulate forcesParticle sizePhysical properties of powdersCarrier and size

DPI 10

characterizationCrystallinityPolymorphismMoisture contentParticle sizeForces of interaction

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MicronizationFluid energy millBall millPin mill

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Evaluation AppearanceColourSieve analysisMoisture contentSpray patternFlow properties

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Current trendsTwisthalerHandihalerTurbuhalersEasyhaler

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CONCLUSIONDrug delivery to lungsImproves aerosol delivery systemsHigh patient compatibilityHigh dose carrying capacityTreatment of asthma and COPD

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Bibliography Frijilink H W, Dry powder inhaler for pulmonary drug delivery

IJPR 2015; 1(1);67-86.Nithi yadav, Alka lohani, Dry powder inhalers. A review, Indo

global journal of pharmaceutical sciences, 2014;3(2);141-171Newman SP, Evolution of dry powder inhalers formulation and

perfomance. Respiratory care 2013 1209-1223Mark copley, accessing Dry powder inhalers. Copley scientific

2012;(3):1027-1028Sahane SP, Nikhar AK. Dry powder inhalers, IJPC 2011;(3)

1143-1149.

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