Inhaled Therapeutics using Dry Powder Inhalers (DPI)

Inhaled Therapeutics using Dry Powder Inhalers (DPI)

Scott Selig ‘19 Biomedical Engineering

Intro: Common Lung Diseases which compromise Airflow

Intro: Common Lung Diseases which compromise Airflow

"Lung Diseases: Types and Causes of Common Conditions." WebMD. Ed. Varnada Karriem-Norwood. WebMD, 23 Mar. 2014. Web. 31 Oct. 2015.

Intro: Problems with Medicating Targeted Area using an Inhaler

Intro: Problems with Medicating Targeted Area using an Inhaler

Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

Intro: Advantages of Dry Powder Inhalers (DPIs)

Intro: Advantages of Dry Powder Inhalers (DPIs)

http://www.capsugel.com/ihc/dry-powder-inhaler-capsules

Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

Method: Testing the Design of the Autohaler™

Method: Testing the Design of the Autohaler™

Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

Autohaler-multi-dose DPI

http://www.mikesouth.org.au/Asthma_devices/MDIs/album/slides/airomir%20autohaler.html http://www.wikihow.com/Use-an-Inhaler

Result: Testing the Design of the Autohaler™

Result: Testing the Design of the Autohaler™

Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

Method: Testing different blends of Lactose Coarse Carrier Particles with varying levels

of Fine Lactose

Method: Testing different blends of Lactose Coarse Carrier Particles with varying levels

of Fine Lactose

Muddle, Joanna, Darragh Murnane, Irene Parisini, Marc Brown, Clive Page, and Ben Forbes. "Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation." Journal of Pharmaceutical Sciences J. Pharm.

- Three different blends of different grade lactose supplement with different levels of fine lactose were used

- Using three different DPIs (Aeroliser, Handihaler, and Rotahaler), the different grades of lactose blends were tested for their in vitro particle distribution and drug deposition

Method: Testing different blends of Lactose Coarse Carrier Particles with varying levels

of Fine Lactose

Method: Testing different blends of Lactose Coarse Carrier Particles with varying levels

of Fine Lactose

Muddle, Joanna, Darragh Murnane, Irene Parisini, Marc Brown, Clive Page, and Ben Forbes. "Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation." Journal of Pharmaceutical Sciences J. Pharm.

Method: Testing different Dry Powder Formulations

Method: Testing different Dry Powder Formulations

Muddle, Joanna, Darragh Murnane, Irene Parisini, Marc Brown, Clive Page, and Ben Forbes. "Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation." Journal of Pharmaceutical Sciences J. Pharm.

Sympatec laser diffraction to determine particle size and shape

www.sympatec.com

Results: Testing different Dry Powder Formulations

Results: Testing different Dry Powder Formulations

Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

(a) LH200 (b) ML001 (c) ML006(white) Aeroliser (black) Handihaler (stripes) Rotahaler

Result: Testing different Dry Powder Formulations

Result: Testing different Dry Powder Formulations

Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

Discussion: Pulmatrix iSperse™Discussion: Pulmatrix iSperse™

Lipp, Michael M., and Jean C. Sung. Respirably Dry Powder Comprising Calcium Lactate, Sodium Chloride and Leucine. Patent 8,992,983. 31 Mar. 2015. Print.

http://bionews-tx.com/news/2014/05/14/pulmatrix-cystic-fibrosis-isperse-antibiotics/

Any questions?Any questions?[1] "Lung Diseases: Types and Causes of Common Conditions." WebMD. Ed. Varnada Karriem-Norwood. WebMD, 23 Mar. 2014. Web. 31 Oct. 2015.

[2] Jat, Kana Ram, Kamal Kumar Singhal, and Vishal Guglani. "Autohaler versus Metered-dose Inhaler with Spacer in Children with Asthma." Pediatr Allergy Immunol Pediatric Allergy and Immunology (2015): n. pag. Pubmed. Web. 31 Oct. 2015.

[3] Muddle, Joanna, Darragh Murnane, Irene Parisini, Marc Brown, Clive Page, and Ben Forbes. "Interaction of Formulation and Device Factors Determine the In Vitro Performance of Salbutamol Sulphate Dry Powders for Inhalation." Journal of Pharmaceutical Sciences J. Pharm. Sci. 104.11 (2015): 3861-869. Pubmed. Web. 31 Oct. 2015.

[4] Holz, Olaf, H. Biller, M. Mueller, K. Kane, M. Rosano, J. Hanrahan, D. L. Hava, and J. M. Hohlfeld. "Efficacy and Safety of Inhaled Calcium Lactate PUR118 in the Ozone Challenge Model - a Clinical Trial." BMC Pharmacology and Toxicology BMC Pharmacol Toxicol 16.1 (2015): n. pag. Web. 31 Oct. 2015.

[5] Lipp, Michael M., and Jean C. Sung. Respirably Dry Powder Comprising Calcium Lactate, Sodium Chloride and Leucine. Patent 8,992,983. 31 Mar. 2015. Print.