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Central Nervous System:

Very rare cases of convulsions have been

reported.

Liver:

There have been liver function test elevations

[AST (SGOT), ALT (SGPT), and GGT] and

rare reports of hepatitis when Mebendazole

was taken for prolonged periods and at

dosages substantially above those

recommended.

Hematologic:

Neutropenia and agranulocytosis. (See

WARNINGS).

Overdosage:

In the event of accidental overdosage,

gastrointestinal complaints lasting up to a few

hours may occur. Vomiting and purging should

be induced.

rules:

Wash hands and fingernails with soap

often during the day, especially before

eating and after using the toilet.

Wear tight underpants both day and

night. Change them daily.

For several days after treatment, clean

the bedroom floor by vacuuming or

damp mopping. Avoid dry sweeping

that may stir up dust.

After treatment, wash bed linens and

night clothes (dont shake them).

Keep the toilet seats clean

The medication used to treat these worms

causes them to be expelled from the body.

Hookworms and whipworms may be seen and

resemble small white threads. Roundworms

are much larger and easily seen.

To help prevent reinfection follow these

rules:

Wash hands and fingernails with soap

often during the day, especially before

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eating and after using the toilet.

Wash all fruits and vegetables

thoroughly or cook them well.

Wear shoes.

Use the bathroom.

Follow your doctors advice, take the

medication he gives you and follow the rules

mentioned here. If you have other questions

about worms, be sure to ask your doctor.

WARNING: Do not take this medication if

you are pregnant or think you may be

pregnant. Consult your physician.

2.) LOMOTIL is the trade name of a popular

oral anti-diarrheal drug in the United States,

manufactured by Pfizer. Its UKBAN generic

name is Co-phenotrope. Its active ingredients

are diphenoxylate and atropine. Diphenoxylate

is anti-diarrheal and atropine is

anticholinergic. Diphenoxylate is chemically

related to the narcotic drug meperidine. A

subtherapeutic amount of atropine sulfate is

Indications and Usage:

Lomotil is effective as adjunctive therapy in

the management of diarrhea.

Contraindications:

Lomotil is contraindicated in patients with

1. Known hypersensitivity to diphenoxylate

Adverse Reactions:

At therapeutic doses, the following have been

reported; they are listed in decreasing order of

severity, but not of frequency:

Nervous system: numbness of extremities,

euphoria, depression, malaise/lethargy,

confusion, sedation/drowsiness, dizziness,

restlessness, headache.

http://en.wikipedia.org/wiki/Trade_namehttp://en.wikipedia.org/wiki/Anti-diarrhealhttp://en.wikipedia.org/wiki/Medicationhttp://en.wikipedia.org/wiki/United_Stateshttp://en.wikipedia.org/wiki/Pfizerhttp://en.wikipedia.org/wiki/British_Approved_Namehttp://en.wikipedia.org/wiki/Diphenoxylatehttp://en.wikipedia.org/wiki/Atropinehttp://en.wikipedia.org/wiki/Anticholinergichttp://en.wikipedia.org/wiki/Narcotichttp://en.wikipedia.org/wiki/Meperidinehttp://en.wikipedia.org/wiki/Trade_namehttp://en.wikipedia.org/wiki/Anti-diarrhealhttp://en.wikipedia.org/wiki/Medicationhttp://en.wikipedia.org/wiki/United_Stateshttp://en.wikipedia.org/wiki/Pfizerhttp://en.wikipedia.org/wiki/British_Approved_Namehttp://en.wikipedia.org/wiki/Diphenoxylatehttp://en.wikipedia.org/wiki/Atropinehttp://en.wikipedia.org/wiki/Anticholinergichttp://en.wikipedia.org/wiki/Narcotichttp://en.wikipedia.org/wiki/Meperidine

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present to discourage deliberate overdosage.

Atropine has no anti-diarrheal properties, but

will cause tachycardia when overused. The

medication diphenoxylate works by slowing

down the movement of the intestines. The

inactive ingredients of Lomotil (as a liquid - it

comes in pill form as well) are cherry flavor,

citric acid, ethyl alcohol 15%, FD&C Yellow

No. 6, glycerin, sodium phosphate, sorbitol,

and water. Other trade names for the same

therapeutic combination are Lofene, Logen,

Lomanate and Lonox, among others. In other

countries, Lomotil may have other names. In

the United States, Lomotil (Diphenoxylate

HCl and atropine sulfate) is classified as a

Schedule V controlled substance by federal

law, and is available only for a medical

purpose.

or atropine.

2. Obstructive jaundice.

3. Diarrhea associated with

pseudomembranous enterocolitis or

enterotoxin-producing bacteria.

Warnings:

Lomotil IS NOT AN INNOCUOUS DRUG

AND DOSAGE RECOMMENDATIONS

SHOULD BE STRICTLY ADHERED TO,

ESPECIALLY IN CHILDREN. Lomotil IS

NOT RECOMMENDED FOR CHILDREN

UNDER 2 YEARS OF AGE. OVERDOSAGE

MAY RESULT IN SEVERE RESPIRATORY

DEPRESSION AND COMA, POSSIBLY

LEADING TO PERMANENT BRAIN

DAMAGE OR DEATH (SEE

OVERDOSAGE). THEREFORE, KEEP THIS

MEDICATION OUT OF THE REACH OF

CHILDREN.

THE USE OF Lomotil SHOULD BE

ACCOMPANIED BY APPROPRIATE

FLUID AND ELECTROLYTE THERAPY,

WHEN INDICATED. IF SEVERE

Allergic: anaphylaxis, angioneurotic edema,

urticaria, swelling of the gums, pruritus.

Gastrointestinal system: toxic megacolon,

paralytic ileus, pancreatitis, vomiting, nausea,

anorexia, abdominal discomfort.

The following atropine sulfate effects are

listed in decreasing order of severity, but not

of frequency: hyperthermia, tachycardia,

urinary retention, flushing, dryness of the skin

and mucous membranes. These effects may

occur, especially in children.

THIS MEDICATION SHOULD BE KEPT IN

A CHILD-RESISTANT CONTAINER AND

OUT OF THE REACH OF CHILDREN

SINCE AN OVERDOSAGE MAY RESULT

IN SEVERE RESPIRATORY DEPRESSION

AND COMA, POSSIBLY LEADING TOPERMANENT BRAIN DAMAGE OR

DEATH.

Drug Abuse and Dependence:

http://en.wikipedia.org/wiki/Tachycardiahttp://en.wikipedia.org/wiki/Diphenoxylatehttp://en.wikipedia.org/wiki/Intestinehttp://en.wikipedia.org/wiki/Cherryhttp://en.wikipedia.org/wiki/Citric_acidhttp://en.wikipedia.org/wiki/Ethyl_alcoholhttp://en.wikipedia.org/wiki/Glycerinhttp://en.wikipedia.org/wiki/Trisodium_phosphatehttp://en.wikipedia.org/wiki/Sorbitolhttp://en.wikipedia.org/wiki/Waterhttp://en.wikipedia.org/wiki/Schedule_Vhttp://www.drugs.com/pro/lomotil.html#section-10#section-10http://en.wikipedia.org/wiki/Tachycardiahttp://en.wikipedia.org/wiki/Diphenoxylatehttp://en.wikipedia.org/wiki/Intestinehttp://en.wikipedia.org/wiki/Cherryhttp://en.wikipedia.org/wiki/Citric_acidhttp://en.wikipedia.org/wiki/Ethyl_alcoholhttp://en.wikipedia.org/wiki/Glycerinhttp://en.wikipedia.org/wiki/Trisodium_phosphatehttp://en.wikipedia.org/wiki/Sorbitolhttp://en.wikipedia.org/wiki/Waterhttp://en.wikipedia.org/wiki/Schedule_Vhttp://www.drugs.com/pro/lomotil.html#section-10#section-10

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DEHYDRATION OR ELECTROLYTE

IMBALANCE IS PRESENT, Lomotil

SHOULD BE WITHHELD UNTIL

APPROPRIATE CORRECTIVE THERAPY

HAS BEEN INITIATED. DRUG-INDUCED

INHIBITION OF PERISTALSIS MAY

RESULT IN FLUID RETENTION IN THE

INTESTINE, WHICH MAY FURTHER

AGGRAVATE DEHYDRATION AND

ELECTROLYTE IMBALANCE.

Lomotil SHOULD BE USED WITH

SPECIAL CAUTION IN YOUNG

CHILDREN BECAUSE THIS AGE GROUP

MAY BE PREDISPOSED TO DELAYED

DIPHENOXYLATE TOXICITY AND

BECAUSE OF THE GREATER

VARIABILITY OF RESPONSE IN THIS

AGE GROUP.

Antiperistaltic agents may prolong and/or

worsen diarrhea associated with organisms

that penetrate the intestinal mucosa (toxigenic

E. coli, Salmonella, Shigella), and

pseudomembranous enterocolitis associated

Controlled Substance:

Lomotil is classified as a Schedule V

controlled substance by federal regulation.

Diphenoxylate hydrochloride is chemically

related to the narcotic analgesic meperidine.

Drug abuse and dependence:

In doses used for the treatment of diarrhea,

whether acute or chronic, diphenoxylate has

not produced addiction.

Diphenoxylate hydrochloride is devoid of

morphine-like subjective effects at therapeutic

doses. At high doses it exhibits codeine-like

subjective effects. The dose which produces

antidiarrheal action is widely separated from

the dose which causes central nervous systemeffects. The insolubility of diphenoxylate

hydrochloride in commonly available aqueous

media precludes intravenous self-

administration. A dose of 100 to 300 mg/day,

which is equivalent to 40 to 120 tablets,

administered to humans for 40 to 70 days,

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