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Authors Lin Chang, MD Jennifer Christie, MD Rosemarie Fisher, MD Rebekah Gross, MD Amy Foxx-Orenstein, MD Asma Khapra, MD Caroline Loeser, MD Suwebatu T. Odunsi, MD Ann Ouyang, MBBS S. Devi Rampertab, MD Robin Rutherford, MD Pratima Sharma, MD, MS Grace L. Su, MD Trinh Truong, MD Jacqueline Wolf, MD Rebecca Van Dyke, MD Senior Author Suzanne Rose, MD, MSEd Professor of Medical Education and Medicine Mount Sinai School of Medicine GASTROSLIDES Project Director Jean-Pierre Raufman Professor of Medicine University of Maryland School of Medicine GASTROSLIDES Art Director Jerry Schoendorf, MAMS Duke University Medical Center Digestive Health and Disease in W men
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AuthorsAuthors
Lin Chang, MDJennifer Christie, MDRosemarie Fisher, MDRebekah Gross, MDAmy Foxx-Orenstein, MDAsma Khapra, MDCaroline Loeser, MDSuwebatu T. Odunsi, MD
Lin Chang, MDJennifer Christie, MDRosemarie Fisher, MDRebekah Gross, MDAmy Foxx-Orenstein, MDAsma Khapra, MDCaroline Loeser, MDSuwebatu T. Odunsi, MD
Ann Ouyang, MBBSS. Devi Rampertab, MDRobin Rutherford, MDPratima Sharma, MD, MSGrace L. Su, MDTrinh Truong, MDJacqueline Wolf, MDRebecca Van Dyke, MD
Ann Ouyang, MBBSS. Devi Rampertab, MDRobin Rutherford, MDPratima Sharma, MD, MSGrace L. Su, MDTrinh Truong, MDJacqueline Wolf, MDRebecca Van Dyke, MD
Senior AuthorSuzanne Rose, MD, MSEd
Professor of Medical Education and Medicine Mount Sinai School of Medicine
Senior AuthorSuzanne Rose, MD, MSEd
Professor of Medical Education and Medicine Mount Sinai School of Medicine
GASTROSLIDES Project DirectorJean-Pierre RaufmanProfessor of Medicine
University of Maryland School of Medicine
GASTROSLIDES Project DirectorJean-Pierre RaufmanProfessor of Medicine
University of Maryland School of Medicine
GASTROSLIDES Art DirectorJerry Schoendorf, MAMS
Duke University Medical Center
GASTROSLIDES Art DirectorJerry Schoendorf, MAMS
Duke University Medical Center
Digestive Health and Disease in W men
Digestive Health and Disease in W men
Pathophysiology of GERDPathophysiology of GERD
Castell Do et al. Aliment Pharmacol Ther 2004; 20 (Suppl 9):14Castell Do et al. Aliment Pharmacol Ther 2004; 20 (Suppl 9):14
Lower esophageal sphincter (LES)Lower esophageal sphincter (LES)
Decreased salivationDecreased salivation
Impaired esophageal acid clearanceImpaired esophageal acid clearance
Impaired tissue resistanceImpaired tissue resistance
Decreasing resting tone of LES
Decreasing resting tone of LES
Delayed gastric emptyingDelayed gastric emptying
Transient LES relaxationTransient LES relaxation
DuodenumDuodenum
GERD / DyspepsiaGERD / Dyspepsia
II-4II-4
Anorectal angle
Anorectal angle
Descent of pelvic floorDescent of pelvic floor
Straining to defecateStraining to defecate
Symphysispubis
Symphysispubis
Anorectal angle
Anorectal angle
CoccyxCoccyx
External anal
sphincter
External anal
sphincter
PuborectalisPuborectalis
RectumRectum
At restAt rest
Pelvic Floor MusculaturePelvic Floor MusculatureConstipationConstipation
IV-9IV-9
Chapron C et al. Human Reproduction 2006: 21:1839Chapron C et al. Human Reproduction 2006: 21:1839
Deeply Infiltrating Endometriosis of the Digestive Tract: Anatomical DistributionDeeply Infiltrating Endometriosis of the Digestive Tract: Anatomical Distribution
Omentum1.7%
Omentum1.7%
Cecum and ileocecal junction4.1%
Cecum and ileocecal junction4.1%
Appendix6.4%Appendix6.4%
Small bowel4.7%
Small bowel4.7%
Sigmoid colon17.4%Sigmoid colon17.4%
Rectosigmoid junction and rectum65.7%
Rectosigmoid junction and rectum65.7%
V-54V-54
Effects of Estrogens/Pregnancy on Transporters Involved in Cholesterol Excretion
Effects of Estrogens/Pregnancy on Transporters Involved in Cholesterol Excretion
CholesterolCholesterol
SinusoidSinusoid
to bile ductto bile duct
LiverLiver
Gall bladderGall bladder
Common bile ductCommon bile duct HepatocyteHepatocyte
NTCPNTCP OATPsOATPs
BilirubinBilirubinBile AcidsBile AcidsNa+Na+
ABC C2ABC C2ABC B11ABC B11
ABC G5/G8ABC G5/G8ABC B4ABC B4
Phosphatidylcholine (PC)
Phosphatidylcholine (PC)
Pregnancy and Liver DiseasePregnancy and Liver Disease
Geier A, et al. BBA 2007; 1773:283Geier A, et al. BBA 2007; 1773:283 VII-79VII-79
Mitochondrial -Oxidation and Oxidative Phosphorylation
Mitochondrial -Oxidation and Oxidative Phosphorylation
Outer membraneOuter membrane
Inner membraneInner membrane
CO2CO2
O2O2
oxidation
oxidation
Citric acid cycle
Citric acid cycle
Acetyl Co-AAcetyl Co-A Fatty acidsFatty acids
NADH e-NADH e-
ATPATPH2OH2O
H+H+ H+H+ H+H+ H+H+
ADP+PiADP+Pi
VIII-61VIII-61
Mitochondrial -Oxidation and Oxidative PhosphorylationMitochondrial -Oxidation and Oxidative Phosphorylation
Barriers to Successful Colonoscopy in Women
Barriers to Successful Colonoscopy in Women
Completion Rates Women 88-96% Men 94.3-99.8%
Anatomical differences Low BMI Previous pelvic surgery
Hysterectomy
Diverticulosis in women
Completion Rates Women 88-96% Men 94.3-99.8%
Anatomical differences Low BMI Previous pelvic surgery
Hysterectomy
Diverticulosis in women
Church JM. American Journal of Gastroenterology 1994; 89(4):556Anderson JC et al. Gastrointestinal Endoscopy 2001; 54(5):558Church JM. American Journal of Gastroenterology 1994; 89(4):556Anderson JC et al. Gastrointestinal Endoscopy 2001; 54(5):558
Special Issues - Colon CancerSpecial Issues - Colon Cancer
IX-12IX-12
NutritionNutrition
X-3X-3
Dietvitamin D3 and D2
Vitamin D3 7-dehydroxycholesterol
Vitamin D3 7-dehydroxycholesterol
UVBUVB
Vitamin D3 + VDBP or albumin
Enterocyte Chylomicron
+vitamin D
Enterocyte Chylomicron
+vitamin D
25-hydroxylase25-hydroxylase
25-OHD25-OHD
1hydroxylase1hydroxylase1,25-(OH)2 vitamin D
Active form of vitamin D1,25-(OH)2 vitamin D
Active form of vitamin D
Terminal ileum
Terminal ileum
Reabsorption of bile salts
and conjugated vitamin D
metabolites
Reabsorption of bile salts
and conjugated vitamin D
metabolitesBile salts and
conjugated vitamin D Bile salts and
conjugated vitamin D
Skin
Small intestine
Small intestine
Vitamin D AbsorptionVitamin D Absorption
