Roselyn Aperocho-Naranjo Pharmacy Instructor USPF, College of Pharmacy.
DOW COLLEGE OF PHARMACY DOW UNIVERSITY … program specimen... · DOW COLLEGE OF PHARMACY DOW...
Transcript of DOW COLLEGE OF PHARMACY DOW UNIVERSITY … program specimen... · DOW COLLEGE OF PHARMACY DOW...
DOW COLLEGE OF PHARMACY
DOW UNIVERSITY OF HEALTH SCIENCES, KARACHI.
M.Phil PROGRAM SPECIFICATION – SPECIMEN
Introduction of Institute & Programs Annex-1 Faculty of Pharmaceutical Sciences Dow College of Pharmacy Dow University of Health Sciences PROGRAMS:
1. M.Phil
Course Title 1. Pharmacology 2. Pharmaceutics 3. Pharmaceutical Chemistry 4. Pharmacognosy 5. Pharmacy Practice
Course Duration M.Phil--------2-4 years
Type of Study Thesis Based Research Work
Study System Annual
Total Credit Hours M.Phil--- 41 credit hours
Credit Hours Distribution-Semester Wise Semester-1= 14 credit hours Semester-2= 15 credit hours Semester-3= 06 credit hours
Course Title with Study Hours Distribution Annex-2
Teaching Hours Distribution Annex-3
Modules Detail with Credit Hours Annex-4
Assessment of Student Internal Evaluation (Throughout Semester= Tests, Viva, Quiz, Presentations, Assignments )= 30 marks Terminal exam=70 Marks (BCQs and SEQs paper)
Degree Awarding Institution Faculty of Pharmaceutical Sciences
Dow College of Pharmacy Dow University of Health Sciences
Eligibility / Admission Criteria 1. Minimum CGPA = 2.45 (For Pharm.D and Allied Sciences)
2. Institutional Entry test Score=50 3. GAT General Score=50
Fee Structure As per university policy for Ph. D. Admission
ANNEXURE-1
Introduction to Program:
The Dow College of Pharmacy in this university was founded in response to the need of better drug
delivery system in hospital and retail pharmacy, and also to cater the ever growing need of
pharmaceutical industry.
The university offers full-time postgraduate program in the key areas of Pharmacy and has developed the
modular format to allow a greater range of options within the program to meet the requirements of
pharmacist who wish to enter teaching and research career in pharmacy and allied health sciences. It
provides a sound understanding of drug and disease and diagnostic and instrumental approaches at the
molecular level applying contemporary techniques of modern biomedicine. It provides opportunities to
acquire and develop the skills of synthesis, analysis and decision making, required for careers in the field
of pharmaceutical research. Thus, the students are trained as the subject specialist, a researcher and a
resource person, well equipped with the methodologies of modern trends of teaching and research in
various disciplines of pharmaceutical sciences. The program involves course work and original research
thesis components.
Five Major Disciplines for which the degrees of Mhil./ Ph.D. are awarded include:
Pharmaceutics
Pharmacology
Pharmaceutical Chemistry
Pharmacognosy
Clinical Pharmacy
Program Mission
To develop integrated programs and impart training for quality education, discipline and character
building for potential postgraduate in Pharmaceutical sciences, & to pharmacy education and research
through multidisciplinary programs of quality education and research that provides outstanding practical
knowledge and experience.
Programme Objectives:
(What the programme would do)
The program will provide every candidate: • Postgraduates in DCOP - a wide variety of career opportunities
• Most of such skilled professionals
– Usually will join teaching career in different areas of pharmaceutical and medical sciences.
– Range from graduate entry to faculty positions in different departments of national/international
pharmacy institutions
• Excellent opportunities
– For clinical pharmacy
– Pharmaceutical management and marketing
– Pharmacy and Medical research
– Graduates wishing to join the pharmaceutical industries, hospitals and teaching institutes.
• Those join industry - employed in
- Production
- Packaging
- Q.C and Q.A
– R & D
– Sales
– Marketing areas
• Those wishing to continue studying in their interested disciplines have opportunities
to undertake postgraduate programs leading to PhD.
– To compete for better prospects in pharmacy institutions
Would be professionals trained as – The subject specialist
– A researcher
– A resource person, well equipped with the methodologies of modern trends of teaching & research in
different disciplines of pharmacy.
Becoming an essential entity for contemporary competitive world in Pharmacy education &
research
Programme Out-Comes:
(What the graduate would be able to do)
(A) Cognitive (Knowledge):
State comprehensive knowledge about the major subject of his/her choice and sound background of the
supportive and skill related courses
(B) Comprehension:
(C) Psychomotor (Skill): area of study and have expertise in
specific technologies.
evaluation
projects
To develop human resources – In the key areas of Pharmacy with a greater range of options within programs, through multidisciplinary
integrated programs of quality education & research;
– For the requirements of pharmacists who wish to enter teaching & research career in pharmacy & allied
health Sciences
It provides a sound understanding of
- Medicinal chemistry
- Synthesis of drug
- Drug formulation
– Human health & disease
– Diagnostic approaches at the molecular level
– Applying contemporary techniques of modern biomedicine, molecular technologies, chemotaxonomy,
toxicology
Provides an opportunity to – Acquire & develop skills of synthesis of learning,
– Grooming of analytical mind
– Critical thinking & decision making
– Required for careers in pharmaceutical research
outstanding practical knowledge & experience
create and disseminate applied information
Enhance understanding, ethical practice of
Medical education & research
ANNEXURE-2
1. Department of Pharmacology: COURSE SCHEME
Semester Title of Course Course Code
No. of Credit Hrs.
Semester-1 .
Biostatistics (Core-I) PCL 701 3
Research methodology (Core-II) PCL 703 3
Principles of Epidemiology (Core-III) PCL 705 3
Pharmacological Research Techniques (Major-I)
PCL 707
2
Molecular Biology and Contemporary Medicine (Major-II)
PCL 709
3
14 Credit hrs.
Semester-II
Medical Genetics and Gene Therapy (Major-III)
PCL 702
3
Autonomic Nervous System & Gastrointestinal System (Major-IV)
PCL 704
2
Anti Microbials and Cancer Chemotherapy (Major-V)
PCL 706 3
Toxicology and Autocoids, NSAIDs (Major-VI)
PCL 708 3
Cardiovascular and Respiratory Pharmacology (Major-VII)
PCL 710 2
Proteomics and Bioinformatics (Major-VIII)
PCL 712 2
15 Credit hrs.
Semester Title of Course Course Code
No. of Credit Hrs.
Semester-3 .
Haemtopoietic System and antihyperlipidemics (Major-IX)
PCL 711
2
Neuropharmacology and Endocrinology (Major-X)
PCL 713
3
Journal Club (Core-IV)
PCL 715
1
6 Credit hrs.
Semester-4 .
Research work and Submission of thesis (Core-V)
PCL 714 6
6 Credit hrs.
Total Credit hours:
Semester-1 Semester-2 Semester-3 Semester-4 Total No. of
Credit Hrs.
14 15 6 6 41
2. Department of Pharmaceutics: COURSE SCHEME
Semester Title of Course Course Code
No. of Credit Hrs.
Semester-1
Biostatistics (Core-I) PCE 701 3
Research Methodology (Core-II) PCE 703 3
Principles of Epidemiology (Core-III) PCE 705 3
Pharmaceutical Instrumentation Techniques (Major-I)
PCE 707 2
Advanced physical Pharmacy (Major-II) PCE 709 2
13 credit hrs.
Semester Title of Course Course Code
No. of Credit Hrs.
Pharmaceutical microbiology (Major-III) PCE 702 2
Semester-2
Advanced Pharmaceutical Technology (Major- IV) PCE 704
3
Advanced Pharmacokinetics (Major- V) PCE 706 3
Pharmaceutical formulation design and development (Major- VI)
PCE 708 3
Clinical Research in Pharmacy (Major-VII) PCE 710 2
Pharmaceutical marketing and management (Major-VIII)
PCE 712 2
15 credit hrs.
Semester Title of Course Course No. of Credit
Code Hrs.
Semester-3 .
Advances in industrial pharmacy (Major-IX) PCE 711 3
Pharmaceutical Quality Management Systems (Major -X)
PCE 713 3
Journal Club (Core-IV) PCE 715
1
7 Credit hrs.
Semester Title of Course Course No. of Credit
Code Hrs.
Semester-4 .
Research work and Submission of thesis (Core-V)
PCE 714
6
6 Credit hrs.
Total Credit hours:
Semester-1 Semester-2 Semester-3 Semester-4 Total No. of
Credit Hrs.
13 15 7 6 41
3. Department of Pharmaceutical Chemistry: COURSE SCHEME
Semester Title of Course Course Code No. of Credit Hrs.
Semester-1
Biostatistics (Core-I) PCH 701 3
Research methodology (Core-II) PCH 703 3
Principles of Epidemiology (Core-III) PCH 705 3
Instrumentation (Major-I) PCH 707 2
Drug Design, synthesis and Stability (Major II) PCH 709 3
14 credit. hrs
Semester-2
Advanced Medicinal Chemistry (Major III) PCH 702 3
Electroanalytical and Chromatographic technique (Major IV)
PCH 704 2
Molecular modeling and computational chemistry (Major V)
PCH 706 3
Quality Control and Quality Assurance (Major VI)
PCH 708 3
Macromolecular target for drug designing (Major VII)
PCH 710 2
Spectroscopic Techniques in structural elucidation (Major VIII)
PCH 712 2
15 credits. Hrs
Semester Title of Course Course Code No. of Credit Hrs.
Semester-3 .
Diagnostic Medicinal Chemistry (Major IX) PCH 711 3
Polymer chemistry (Major X) PCH 713 2
Journal Club (Core-IV) PCH 715
1
6 Credit hrs.
Semester-4 .
Research work and Submission of thesis (Core-V)
PCH 714
6
6 Credit hrs.
Total Credit hours:
Semester-1 Semester-2 Semester-3 Semester-4 Total No. of
Credit Hrs.
14 15 6 6 41
4. Department of Pharmacognosy: COURSE SCHEME
Title of Course Course Code No. of Credit Hrs.
Semester-I
Biostatistics (Core-I) PCG 701
3
Research Methodology (Core-II)
PCG 703
3
Principles of Epidemiology (Core-III) PCG 705
3
Pharmacognostic Instrumentation Techniques (Major I)
PCG 707
2
Science and Clinical Practice of Herbal Medicine (Major II)
PCG 709
3
14 credit hrs.
Semester-II
Natural Products Drug Discovery (Major-III) PCG 702 3
Cosmeceuticals and Neutraceuticals (Major-IV) PCG 704
3
Natural Toxicology (Major-V) PCG 706
2
Biosynthesis of Natural Products (Major-VI) PCG 708
2
Regulatory Affairs of Herbal Medicine (Major-VII)
PCG 710
2
Structure Elucidation of natural products (Major-VIII)
PCG 712
3
15 credit hrs.
Semester Title of Course Course Code No. of Credit Hrs.
Semester-3 .
Nutritional Herbology (Major-IX)
PCG 711
3
Agricultural Pharmacy (Major-X)
PCG 713
2
Journal Club (Core-IV) PCG 715
1
6 Credit hrs.
Semester-4 .
Research work and Submission of thesis (Core-V)
PCG 714
6
6 Credit hrs.
Total Credit hours:
Semester-1 Semester-2 Semester-3 Semester-4 Total No. of
Credit Hrs.
14 15 6 6 41
5. Department of Pharmacy Practice: COURSE SCHEME
Semester Title of Course Course
Code
No. of Credit
Hrs.
Semester-1
.
Biostatistics (Core-I) PPR 701 3
Research methodology (Core-II) PPR 703 3
Principles of Epidemiology (Core-III) PPR 705 3
Pharmacotherapeutics- I (Major-I) PPR 707
3
Clinical Biochemistry (Major-II) PPR 709
3
15 Credit hrs.
Semester-II
Pharmacotherapeutics- II (Major-III) PPR 702
3
Advanced Clinical Pharmacy Practice
(Major-IV)
PPR 704
2
Regulatory Guidelines In Clinical
Pharmacy Practice (Major-V)
PPR 706 2
Applied Clinical Pharmacokinetics (Major-
VI)
PPR 708 3
Clinical Trial (Major-VII) PPR 710 2
Health Management in Pharmacy Pratice
(Major-VIII)
PPR 712 2
14 Credit hrs.
Semester Title of Course Course
Code
No. of Credit
Hrs.
Semester-3
.
Pharmacotherapeutics – III (Major-IX) PPR 711
2
Pharmacovigilance (Major-X) PPR 713 3
Journal Club(Core-IV)
PPR 715
1
6 Credit hrs.
Semester-4
.
Research work and Submission of thesis
(Core-V)
PPR 714 6
6 Credit hrs.
Total Credit hours:
Semester-1 Semester-2 Semester-3 Semester-4 Total No. of
Credit Hrs.
15 14 6 6 41
ANNEXURE-3
TIME TABLE M,Phil & M.Phil Leading to Ph.D
DEPARTMENT OF PHARMACOLOGY FACULTY OF PHARMACEUTICAL SCIENCES
DOW COLLEGE OF PHARMACY, DUHS, KARACHI
EFFECTIVE FROM :11th
November, 2014 SEMESTER 1
DAYS 9:00 – 10:00 10:00 – 11:00 11:00 – 12:00 12:00 – 1:00 1:00 – 2:00 2:00 – 3:00
Monday Course # PCL 701
Tuesday
Self Study Group Discussion
Digital Library Seminar Library Digital Library Self Study
Wednesday
Course # PCL 707
Course # PCL 707
Course # PCL 709
Course # PCL 709
Course # PCL 709 Group Discussion
Thursday Course # PCL 705 Course # PCL 705
Course # PCL 705 Course # PCL 703 Course # PCL 703 Course # PCL 703
Friday Self Study Digital Library
Self Study Group Discussion Seminar Library Group Discussion
Saturday Seminar Library Self Study Group Discussion Digital Library Self Study Group Discussion
Course # Subject Instructor Name Course # Subject Instructor Name
PCL 701 Biostatistics (Core) RESEARCH DEPARTMENT, DUHS
PCL 709 Molecular Biology and Contemporary Medicine (Major-
II)
PATHOLOGY DEPARTMENT,
DIMS,DUHS
PCL 703 Research methodology (Core) RESEARCH DEPARTMENT, DUHS
PCL 705 Epidemiology (Core) RESEARCH DEPARTMENT, DUHS
PCL 707 Pharmacological Research Techniques (Major-I)
DOW COLLEGE OF PHARMACY:
Prof. Dr. Sumbul Shamim Ms. Saima Mehmood
Dr. Sana Shamim Dr. Moona Khan
TIME TABLE M,Phil & M.Phil Leading to Ph.D
DEPARTMENT OF PHARMACEUTICS FACULTY OF PHARMACEUTICAL SCIENCES
DOW COLLEGE OF PHARMACY, DUHS, KARACHI
EFFECTIVE FROM :11th
November, 2014 SEMESTER 1
DAYS 9:00 – 10:00 10:00 – 11:00 11:00 – 12:00 12:00 – 1:00 1:00 – 2:00 2:00 – 3:00
Monday Course # PCE 701
Tuesday
Self Study Group Discussion
Digital Library Seminar Library Digital Library Self Study
Wednesday
Course # PCE 707
Course # PCE 707
Course # PCE 709
Course # PCE 709
Self Study Group Discussion
Thursday Course # PCE 705 Course # PCE 705
Course # PCE 705 Course # PCE 703 Course # PCE 703 Course # PCE 703
Friday Self Study Digital Library
Self Study Group Discussion Seminar Library Group Discussion
Saturday Seminar Library Self Study Group Discussion Digital Library Self Study Group Discussion
Course # Subject Instructor Name Course # Subject Instructor Name
PCE 701 Biostatistics (Core) RESEARCH DEPARTMENT, DUHS
PCE 707 Pharmaceutical Instrumentation Techniques (Major I)
Dr. Tariq Ali Dr. Moona Khan
Dr. Sana Shamim
PCE 703 Research methodology (Core) RESEARCH DEPARTMENT, DUHS
PCE 709 Advanced physical Pharmacy (Major II)
Dr. Najia Rahim Ms. Riffat Yasmin
PCE 705 Epidemiology (Core) RESEARCH DEPARTMENT, DUHS
16
ANNEXURE-3
Department of Pharmaceutical Chemistry:
COURSE SCHEME- M.PHIL.
Semester Title of Course Course
Code
No. of Credit
Hrs.
Semester-1
Biostatistics (Core-I) PCH 701 3
Research methodology (Core-II) PCH 703 3
Principles of Epidemiology (Core-III) PCH 705 3
Instrumentation (Major-I) PCH 707 2
Drug Design, synthesis and Stability (Major
II)
PCH 709 3
14 credit. hrs
Semester-2
Advanced Medicinal Chemistry (Major III) PCH 702 3
Electroanalytical and Chromatographic
technique (Major IV)
PCH 704 2
Molecular modeling and computational
chemistry (Major V)
PCH 706 3
Quality Control and Quality Assurance
(Major VI)
PCH 708 3
Macromolecular target for drug designing
(Major VII)
PCH 710 2
Spectroscopic Techniques in structural
elucidation (Major VIII)
PCH 712 2
15 credit. Hrs
Semester Title of Course Course
Code
No. of Credit
Hrs.
Semester-3
.
Diagnostic Medicinal Chemistry (Major IX) PCH 711 3
Polymer chemistry (Major X) PCH 713 2
Journal Club (Core-IV) PCH 715
1
6 Credit hrs.
Semester-4
.
Research work and Submission of thesis
(Core-V)
PCH 714
6
6 Credit hrs.
Total Credit hours:
Semester-1 Semester-2 Semester-3 Semester-4 Total No. of
Credit Hrs.
17
14 15 6 6 41
Department of Pharmaceutical Chemistry:
Course Details: For each course in the program that can be counted for credit provide 1-2
pages specifying the following:
SEMESTER-1
Course Title
PCH 701- BIOSTATISTICS (CORE-I)
Course Objective
This course is designed to give students experience and confidence in the design and
analysis of data within realistic biological research contexts. Students will gain basic
practical experience in collecting, displaying, summarizing, analyzing and interpreting
biological data in applied research contexts using standard statistical methods.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction of Data Organization
(Grouping Data)
1 hour Explain/demonstrate/
assignments/
presentations.
2 Data Organization (Graphs and
Charts
1 hour Explain/demonstrate/
assignments/
presentations.
3 Symbols and Summation Notation
Sample and Population
1 hour Explain/demonstrate/
assignments/
presentations.
4 Measures of Central Tendency 1 hour Explain/demonstrate/
assignments/
presentations.
5 Measures of Dispersion 1 hour Explain/demonstrate/
assignments/
presentations.
6 Probability 1 hour Explain/demonstrate/
assignments/
presentations.
7 Probability 1 hour Explain/demonstrate/
18
assignments/
presentations.
8 Probability 1 hour Explain/demonstrate/
assignments/
presentations.
9 Discrete Probability Distribution: 1 hour Explain/demonstrate/
assignments/
presentations.
10 Discrete Probability Distribution: 1 hour Explain/demonstrate/
assignments/
presentations.
11 Binomial, Poisson and Normal
Distributions:
1 hour Explain/demonstrate/
assignments/
presentations.
12 Binomial, Poisson and Normal
Distributions:
1 hour Explain/demonstrate/
assignments/
presentations.
13 Sampling Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
14 Estimating Means (Large Sample 1 hour Explain/demonstrate/
assignments/
presentations.
15 Hypothesis Testing: One Sample
Test
1 hour Explain/demonstrate/
assignments/
presentations.
16 Hypothesis Testing: One Sample
Test
1 hour Explain/demonstrate/
assignments/
presentations.
17 Hypothesis Testing: One Sample
Test
1 hour Explain/demonstrate/
assignments/
presentations.
18 Two Sample Test (Independent
Population)
1 hour Explain/demonstrate/
assignments/
presentations.
19 Two Sample Test (Independent
Population)
1 hour Explain/demonstrate/
assignments/
presentations.
20 Two Sample Test (Independent
Population)
1 hour Explain/demonstrate/
assignments/
presentations.
21 Two Sample Test (Paired And
Proportion)
1 hour Explain/demonstrate/
assignments/
presentations.
22 Two Sample Test (Paired And
Proportion)
1 hour Explain/demonstrate/
assignments/
19
presentations.
23 Two Sample Test (Paired And
Proportion)
1 hour Explain/demonstrate/
assignments/
presentations.
24 Chi-Square Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
25 Chi-Square Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
26 Chi-Square Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
27 Analysis Of Variance One Way
ANOVA
1 hour Explain/demonstrate/
assignments/
presentations.
28 Analysis Of Variance One Way
ANOVA
1 hour Explain/demonstrate/
assignments/
presentations.
29 Analysis Of Variance One Way
ANOVA
1 hour Explain/demonstrate/
assignments/
presentations.
30 Analysis Of Variance Two Way
ANOVA
1 hour Explain/demonstrate/
assignments/
presentations.
31 Analysis Of Variance Two Way
ANOVA
1 hour Explain/demonstrate/
assignments/
presentations.
32 Factorial ANOVA 1 hour Explain/demonstrate/
assignments/
presentations.
33 Factorial ANOVA 1 hour Explain/demonstrate/
assignments/
presentations.
34 Regression, Multiple Regression
And Correlation
1 hour Explain/demonstrate/
assignments/
presentations.
35 Regression, Multiple Regression
And Correlation
1 hour Explain/demonstrate/
assignments/
presentations.
36 Non Parametric Statistics 1 hour Explain/demonstrate/
assignments/
presentations.
37 Non Parametric Statistics 1 hour Explain/demonstrate/
assignments/
presentations.
20
38 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
39 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
40 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
Text and Reference Books Heath, D. An Introduction to Experimental Design and Statistics for Biology, London, UCL Press, 1995.
Campbell, S. K. Flaws and Fallacies in Statistical Thinking, Prentice-Hall, 1974.
Fisher, R. A. The Design of Experiments. Hafner, 1971.
Gonick, L. and Smith, W. The Cartoon Guide to Statistics. Harper Perennial, 1993
Moses, L. E. Think and Explain with Statistics. Addison Wesley, 1986.
Salsburg, D. S. Understanding Randomness. Lecture Notes in Statistics, Vol. 6 Marcel Dekker, 1983.
Sokal, R. R. and F. J. Rohlf. Introduction to Biostatistics, 2nd
, 3ed. Freeman, 1987.
Zar, J. Biostatistical Analysis. Prentice Hall, 1984.
Course Title
PCH 703- RESEARCH METHODOLOGY (CORE-II)
Course Objective
The objectives of the course are:
To provide students with the tools and skills required to understand research terminology
and assess published research; to identify the types of methods best suited for
investigating different types of problems and questions, to design a research proposal and to begin initial preparations for embarking on a new research project.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1
Introduction 1 hour Explain/demonstrate/
assignments/
presentations.
2
Research Objective
1 hour Explain/demonstrate/
assignments/
presentations.
3 Selection of the area of research
1 hour Explain/demonstrate/
assignments/
presentations.
4 Selection of the area of research 1 hour Explain/demonstrate/
assignments/
21
presentations.
5 Selection of research
guide/supervisor
1 hour Explain/demonstrate/
assignments/
presentations.
6 Selection of research
guide/supervisor
1 hour Explain/demonstrate/
assignments/
presentations.
7 Selection of topic/ problem
1 hour Explain/demonstrate/
assignments/
presentations.
8 Selection of topic/ problem
1 hour Explain/demonstrate/
assignments/
presentations.
9 Selection of topic/ problem
1 hour Explain/demonstrate/
assignments/
presentations.
10 Construction of a strong statement
that summarizes the selected topic.
1 hour Explain/demonstrate/
assignments/
presentations.
11 Construction of a strong statement
that summarizes the selected topic.
1 hour Explain/demonstrate/
assignments/
presentations.
12 Sources of information
1 hour Explain/demonstrate/
assignments/
presentations.
13 Books, journals/periodicals, old
testimonials.
1 hour Explain/demonstrate/
assignments/
presentations.
14 News papers, internet; proceedings
of conferences
1 hour Explain/demonstrate/
assignments/
presentations.
15 Seminars, workshops and training
programs; conversations
1 hour Explain/demonstrate/
assignments/
presentations.
16 Detail of Equipments/ Fields/ Area
1 hour Explain/demonstrate/
assignments/
presentations.
17 Type of Instruments: Models, make
and country of origin;
1 hour Explain/demonstrate/
assignments/
presentations.
18 Validation: reliability and accuracy 1 hour Explain/demonstrate/
assignments/
presentations.
22
19 Service centers, availability of
supplies and engineers; Environment:
laboratory conditions.
1 hour Explain/demonstrate/
assignments/
presentations.
20 Service centers, availability of
supplies and engineers; Environment:
laboratory conditions
1 hour Explain/demonstrate/
assignments/
presentations.
21 Plan of work 1 hour Explain/demonstrate/
assignments/
presentations.
22 Collection of material/authentication
1 hour Explain/demonstrate/
assignments/
presentations.
23 Collection of material/authentication
1 hour Explain/demonstrate/
assignments/
presentations.
24 Preliminary screening/pilot plan
1 hour Explain/demonstrate/
assignments/
presentations.
25 Preliminary screening/pilot plan
1 hour Explain/demonstrate/
assignments/
presentations.
26 Experimental: detailed procedure 1 hour Explain/demonstrate/
assignments/
presentations.
27 Experimental: detailed procedure 1 hour Explain/demonstrate/
assignments/
presentations.
28 Experimental: detailed procedure 1 hour Explain/demonstrate/
assignments/
presentations.
29 Places for practical work and
resources
1 hour Explain/demonstrate/
assignments/
presentations.
30 Places for practical work and
resources
1 hour Explain/demonstrate/
assignments/
presentations.
31 Places for practical work and
resources
1 hour Explain/demonstrate/
assignments/
presentations.
32 Places for practical work and
resources
1 hour Explain/demonstrate/
assignments/
presentations.
23
33 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
34 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
35 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
36 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
37 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
38 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
39 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
40 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
Text and Reference Books
Luker, K. (2010). Salsa dancing into the social sciences. Cambridge, MA: Harvard University Press. (ISBN
9780674048218).
Knight, P.T. (2002). Small-scale research. Thousand Oaks, CA: Sage Publications (ISBN-10: 0761968628 /
ISBN-13: 978-0761968627).
Myers, Michael D. "Qualitative Research in Information Systems”, AISWorld Section on Qualitative Research,
www.qual.auckland.ac.nz
Myers, Michael D., and David Avison (eds.). Qualitative Research in Information
Systems: A Reader. Sage Publications, 2002.
Lee, A.S., Liebenau, J. and DeGross, J.I. (eds.). Information Systems and Qualitative Research, Chapman and
Hall, London, 1997.
Yin, Robert K. Case Study Research: Design and methods. Third edition. Sage Publications, 2003.
Walsham, G. Interpreting Information Systems in Organizations. John Wiley and Sons, Chichester, 1993.
Wolcott, H. Writing up Qualitative Research. Sage Publications, Thousands Oaks, CA, 1990.
24
PCH 705: PRINCIPLES OF EPIDEMIOLOGY (Core-III)
COURSE OBJECTIVES: At the end of the lecture, the student will be able to:
Define Epidemiology, disease Transmission.
Explain Measuring the occurrence of disease: Morbidity and Mortality, Assessing the Validity
and Reliability of diagnostic and screening tests.
Identify the roles of genetic and environmental factors in disease causation,
Evaluate health services by Epidemiology.
Lecture
No
Title of Lecture Dura
tion
Teaching
Method
1
Introduction
1
hour
Lecture/ power
point
2 The dynamics of disease Transmission
“ “
3 The dynamics of disease Transmission
“ “
4 Measuring the occurrence of disease:
Morbidity and Mortality
“ “
5 Measuring the occurrence of disease:
Morbidity and Mortality
“ “
6 Measuring the occurrence of disease:
Morbidity and Mortality
7 Assessing the Validity and Reliability of
diagnostic and screening tests
“ “
8 Assessing the Validity and Reliability of
diagnostic and screening tests
“ “
9 Assessing the Validity and Reliability of
diagnostic and screening tests
“ “
10 Understanding biases and confounding “ “
11 Understanding biases and confounding “ “
12 Cohort Studies “ “
13 Cohort Studies “ “
25
14 Case-Control Studies and other study designs “ “
15 Comparing Cohort and Case-Control Studies “ “
16 Comparing Cohort and Case-Control Studies “ “
17 Indentifying the roles of genetic and
environmental factors in disease causation
“ “
18 Indentifying the roles of genetic and
environmental factors in disease causation
“ “
19 Using Epidemiology to evaluate health
services
“ “
20 Using Epidemiology to evaluate health
services
“ “
21 The epidemiologic approach to evaluating
screening programs
“ “
22 Epidemiology and public policy “ “
23 Epidemiology and public policy “ “
24 Measure of association I (Relative risk/odds
ratio/ standardized mortality
ratios/Attributable risk)
“ “
25 Measure of association I (Relative risk/odds
ratio/ standardized mortality
ratios/Attributable risk)
26 Ethical and professional issues in
Epidemiology
“ “
27 Ethical and professional issues in
Epidemiology
“ “
28 Investigation of disease outbreak “ “
29 Investigation of disease outbreak “ “
30 Causal inference “ “
31 Causal inference “ “
26
Course Title
PCH 705- INSTRUMENTATION (Major-I)
Course Objective
The course objective is to introduce the participants to modern instrumental techniques
and analytical approaches usually applied in pharmaceutical chemistry research. The
main purpose of the Course is to provide students with a strong theoretical and practical
grounding in the principles and practices of analytical chemistry, including classical and
instrumental analytical techniques. This Course also aims to develop advanced laboratory
skills in analytical chemistry.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction to analytical methods 1 hour Explain/demonstrate/
assignments/
presentations.
2 Introduction of Chemical methods 1 hour Explain/demonstrate/
assignments/
presentations.
3 Activation Analysis 1 hour Explain/demonstrate/
assignments/
presentations.
4 Analytic Sample Preparation
Methods
1 hour Explain/demonstrate/
assignments/
presentations.
5 Binding, Competitive 1 hour Explain/demonstrate/
assignments/
presentations.
6 Biuret Reaction 1 hour Explain/demonstrate/
assignments/
presentations.
7 Calorimetry 1 hour Explain/demonstrate/
assignments/
presentations.
8 Chemical Fractionation 1 hour Explain/demonstrate/
assignments/
presentations.
9 Chemical Precipitation 1 hour Explain/demonstrate/
assignments/
presentations.
27
10 Chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
11 Countercurrent Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
12 Crystallization 1 hour Explain/demonstrate/
assignments/
presentations.
13 Crystallography 1 hour Explain/demonstrate/
assignments/
presentations.
14 Desiccation 1 hour Explain/demonstrate/
assignments/
presentations.
15 Deuterium Exchange Measurement 1 hour Explain/demonstrate/
assignments/
presentations.
16 Dialysis 1 hour Explain/demonstrate/
assignments/
presentations.
17 Differential Thermal Analysis 1 hour Explain/demonstrate/
assignments/
presentations.
18 Electroosmosis 1 hour Explain/demonstrate/
assignments/
presentations.
19 Electrophoresis 1 hour Explain/demonstrate/
assignments/
presentations.
20 Enzyme Assays 1 hour Explain/demonstrate/
assignments/
presentations.
21 Filtration 1 hour Explain/demonstrate/
assignments/
presentations.
22 Flow Injection Analysis 1 hour Explain/demonstrate/
assignments/
presentations.
23 Glucose Clamp Technique 1 hour Explain/demonstrate/
assignments/
presentations.
24 Mass Spectrometry 1 hour Explain/demonstrate/
assignments/
presentations.
25 Microchemistry 1 hour Explain/demonstrate/
28
assignments/
presentations.
26 Microchip Analytical Procedures 1 hour Explain/demonstrate/
assignments/
presentations.
27 Molecular Imprinting 1 hour Explain/demonstrate/
assignments/
presentations.
28 Nucleotide Mapping 1 hour Explain/demonstrate/
assignments/
presentations.
29 Osmometry 1 hour Explain/demonstrate/
assignments/
presentations.
30 Peptide Mapping 1 hour Explain/demonstrate/
assignments/
presentations.
31 Physico-chemical methods 1 hour Explain/demonstrate/
assignments/
presentations.
32 Bio-chemical methods 1 hour Explain/demonstrate/
assignments/
presentations.
33 Photometry 1 hour Explain/demonstrate/
assignments/
presentations.
34 Polarography 1 hour Explain/demonstrate/
assignments/
presentations.
35 Quartz Crystal Microbalance
Techniques
1 hour Explain/demonstrate/
assignments/
presentations.
36 Refractometry 1 hour Explain/demonstrate/
assignments/
presentations.
37 Scattering, Radiation 1 hour Explain/demonstrate/
assignments/
presentations.
38 Spectrum Analysis 1 hour Explain/demonstrate/
assignments/
presentations.
39 Spin Trapping, Surface Plasmon
Resonance, Thermogravimetry
1 hour Explain/demonstrate/
assignments/
presentations.
40 Titrimetry, Ultracentrifugation 1 hour Explain/demonstrate/
assignments/
29
presentations.
Text and Reference Books Analytical Aspects of Drug testing. Edt. Dale G Deutsch, John Wiley & Sons (1989).
Analytical Profiles of Drug substances and excipients. Rosenstock, J, Academic Press, New York (1998)
Biopharmaceutical and Biotechnology. Gary Walsh , John Wiley and Sons , U.K (1999)
Burger‟s Medicinal Chemistry and Drug discovery edited by Donald J. Abraham, John Wiley & Sons
incorporated Philadelphia (2003)
Analysis and Detection by Capillary Electrophoresis, Edited by Maria Luisa Marina, Angel Ríos and
Miguel Valcárcel, Elsevier (2005)
Drug interaction 2nd edition , Stockely H., Blackwell scientific Publication, London (1991)
Pharmaceutical Pre formulation: The physico chemical properties of Drug Substances, Wells Halsted, New
York (1988).
Pharmaceuticals in the Environments: Sources, Fate, Effect and Risk. Klaus Kummerer, 2nd edition,
Springer (2004).
Physical Chemistry for the Bioscience. Raymond Chang, University Science Books (2005).
Analytical Chemistry; An Introduction, D. A. Skoog, D. M. West and F. J. Holler, 6th Edn., Saunders
College Publishing, Philadelphia, 1994.
Analytical Chemistry, An Introduction, D. A. Skoog, D. M. West, F. J. Holler, and S. R. Crouch, 7th Edn.,
Saunders College Publishing, Philadelphia, 1998.
Analytical Chemistry, G. D. Christian, 5th Edn., Wiley, New York, 1994.
Environmental Analytical Chemistry, Blackie, F. W. Fifield and P. J. Haines (Eds.), Academic and
Professional, London, 1995.
Principle of Instrumental Analysis, D. A. Skoog, F. J. Holler and A. N. Timothy, , 5th Edn., Saunders
College Publishing, Philadelphia, 1998
Practical Pharmaceutical Chemistry, A. H. Beckett and J.B Stenlake, Vol I and II, CBS publishers and
Distributors 11, Darya Ganj , New Delhi (2004).
Course Title
PCH 707- DRUG DESIGN, SYNTHESIS AND STABILITY (Major-II)
Course Objective
Enable you to develop a systematic understanding, critical awareness, and skills in
selected disciplines within the field of drug discovery. Provide you with a detailed
knowledge of common strategies and methods for the design and discovery of new
medicines. Provide a strong knowledge base in the theory and practical skills of synthetic
organic chemistry and their application in drug discovery. Develop within the context of
drug discovery, a comprehensive understanding of communication, research skills and
scientific method. Provide learning opportunities to enable you to think critically and to
further develop as an autonomous and lifelong learner. Further develop your ability in a
range of personal and key skills.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
Introduction to drug designing 1 hour Explain/demonstrate/
30
1 assignments/
presentations.
2 Types to drug designing 1 hour Explain/demonstrate/
assignments/
presentations.
3
The overview of strategy behind the
design and synthesis of new drug
molecule
1 hour Explain/demonstrate/
assignments/
presentations.
4 The overview of strategy behind the
design and synthesis of new drug
molecule
1 hour Explain/demonstrate/
assignments/
presentations.
5 The overview of strategy behind the
design and synthesis of new drug
molecule
1 hour Explain/demonstrate/
assignments/
presentations.
6 Fundamentals of rational design 1 hour Explain/demonstrate/
assignments/
presentations.
7 Fundamentals of rational design 1 hour Explain/demonstrate/
assignments/
presentations.
8 Fundamentals of HTS 1 hour Explain/demonstrate/
assignments/
presentations.
9 Computer based drug design 1 hour Explain/demonstrate/
assignments/
presentations.
10 Types of software 1 hour Explain/demonstrate/
assignments/
presentations.
11 Software related to structure
drawing
1 hour Explain/demonstrate/
assignments/
presentations.
12 Software related to structure
drawing
1 hour Explain/demonstrate/
assignments/
presentations.
13 Software related to structure
drawing
1 hour Explain/demonstrate/
assignments/
presentations.
14 Screening methods 1 hour Explain/demonstrate/
assignments/
presentations.
15 Types of screening 1 hour Explain/demonstrate/
assignments/
presentations.
16 Bio-screening 1 hour Explain/demonstrate/
31
assignments/
presentations.
17 Bio-screening 1 hour Explain/demonstrate/
assignments/
presentations.
18 Rational screening 1 hour Explain/demonstrate/
assignments/
presentations.
19 Extensive screening 1 hour Explain/demonstrate/
assignments/
presentations.
20 Random screening 1 hour Explain/demonstrate/
assignments/
presentations.
21 Structure Activity Relationship
(SAR)
1 hour Explain/demonstrate/
assignments/
presentations.
22 Structure Activity Relationship
(SAR) of Analgesics
1 hour Explain/demonstrate/
assignments/
presentations.
23 Structure Activity Relationship
(SAR)
1 hour Explain/demonstrate/
assignments/
presentations.
24 Q- Structure Activity Relationship
(QSAR)
1 hour Explain/demonstrate/
assignments/
presentations.
25 Synthesis of organic compounds, 1 hour Explain/demonstrate/
assignments/
presentations.
26 Methodology of synthesis 1 hour Explain/demonstrate/
assignments/
presentations.
27 Methodology of synthesis 1 hour Explain/demonstrate/
assignments/
presentations.
28 Chemical reactions, 1 hour Explain/demonstrate/
assignments/
presentations.
29 Types of chemical reactions. 1 hour Explain/demonstrate/
assignments/
presentations.
30 Drug stability 1 hour Explain/demonstrate/
assignments/
presentations.
31 Drug stability 1 hour Explain/demonstrate/
assignments/
32
presentations.
32 Drug stability 1 hour Explain/demonstrate/
assignments/
presentations.
33 Drug stability 1 hour Explain/demonstrate/
assignments/
presentations.
34 Enzyme and receptor protein targets
are examined, together with the
mechanisms by which the drugs
work.
1 hour Explain/demonstrate/
assignments/
presentations.
35 Enzyme and receptor protein targets
are examined, together with the
mechanisms by which the drugs
work.
1 hour Explain/demonstrate/
assignments/
presentations.
36 Enzyme and receptor protein targets
are examined, together with the
mechanisms by which the drugs
work.
1 hour Explain/demonstrate/
assignments/
presentations.
37 Enzyme and receptor protein targets
are examined, together with the
mechanisms by which the drugs
work.
1 hour Explain/demonstrate/
assignments/
presentations.
38 Enzyme and receptor protein targets
are examined, together with the
mechanisms by which the drugs
work.
1 hour Explain/demonstrate/
assignments/
presentations.
39 Enzyme and receptor protein targets
are examined, together with the
mechanisms by which the drugs
work.
1 hour Explain/demonstrate/
assignments/
presentations.
40 Enzyme and receptor protein targets
are examined, together with the
1 hour Explain/demonstrate/
assignments/
presentations.
33
mechanisms by which the drugs
work.
Text and Reference Books Textbook of Drug Design and Discovery, Krogsgaard-Larsen, P.; Liljefors, T.; Madsen, U. (Eds.), Taylor
& Francis, 2002
Drug Design: Cutting Edge Approaches, Flower, D.R. (Ed.), Royal Society of Chemistry, 2003
Design of Drugs: Basic Principles and Applications, Poupaert, J.H. (Ed.), Marcel Dekker, 2002
Modern Methods of Drug Discovery, Hillisch, A.; Hilgenfeld, R. (Eds.), Springer Verlag, 2003
Structure-Based Drug Design, Veerapandian, P. (Ed.), Marcel Dekker, 1997
Pharmacokinetic Optimization in Drug Research, Testa, B.; van de Waterbeemd, H.; Folkers, G.; Guy, R.
(Eds.), VCH Verlagsgesellschaft mbH, 2002
Pharmacokinetics and Metabolism in Drug Design, Smith, D.A.; van de Waterbeemd, H.; Walker, D.K.
(Eds.), John Wiley & Sons, 2000
Drug Discovery and Evaluation, Vogel, H. (Ed.), Springer Verlag, 2002
Statistics in Drug Research: Methodologies and Recent Developments, Chow, S.-C.; Shao, J. (Eds.),
Marcel Dekker, 2002
Chirality in Drug Design and Development, Reddy, I.K.; Mehvar, R. (Eds.), Marcel Dekker, 2004
Pharmacogenomics: The Search for Individualized Therapies, Licinio, J.; Wong, M.-L. (Eds.), VCH
Verlagsgesellschaft mbH, 2002
Pharmacophore Perception, Development, and Use in Drug Design, Güner, O.F. (Eds.), International
University Line, 2000
The Organic Chemistry of Drug Design and Drug Action, Silverman, R. (Ed.)
Academic Press, 2004
Practical Application of Computer-Aided Drug Design, Charifson, P.S. (Eds.)
Marcel Dekker, 1997
3D QSAR in Drug Design: Ligand-Protein Interactions and Molecular Similarity, Kubinyi, H.; Martin,
Y.C.; Folkers, G. (Eds.), Kluwer Academic Publishers, 1998
Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens, Benigni, R.
(Ed.), CRC Press, 2003
Structure-Property Correlations in Drug Research, van de Waterbeemd, H. (Ed.), Academic Press, 1996
Structure-based Ligand Design, Gubernator, K.; Böhm, H.-J. (Eds.)
VCH Publishing, 1998
Protein-Ligand Interactions : From Molecular Recognition to Drug Design, Böhm, H.-J.; Schneider, G.
(Eds.), John Wiley & Sons, 2003
Drug-Membrane Interactions : Analysis, Drug Distribution, Modeling, Seydel, J.K.; Wiese, M. (Eds.),
VCH Verlagsgesellschaft mbH, 2002
Guidebook on Molecular Modeling in Drug Design, Cohen, N. (Ed.)
Academic Press, 1996
Protein Structure. Determination, Analysis ,and Application for Drug Discovery, Chasman, D. (Ed.),
Marcel Dekker, 2003
SEMESTER-2
PCH 702- ADVANCED MEDICINAL CHEMISTRY (Major-III)
Course Objective
The objectives of the course are to provide students a broad and balanced introduction to
the background, concepts and tools of medicinal chemistry, a science at the interface of
synthetic chemistry, physicochemistry, phytochemistry, biochemistry, pharmacology and
toxicology, drug metabolism and disposition, molecular modeling and informatics.
34
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1
Introduction 1 hour Explain/demonstrate/
assignments/
presentations.
2
Discusses the chemical
characteristics of drugs
1 hour Explain/demonstrate/
assignments/
presentations.
3 Discusses the chemical
characteristics of drugs
1 hour Explain/demonstrate/
assignments/
presentations.
4 Drug targets 1 hour Explain/demonstrate/
assignments/
presentations.
5 Drug targets 1 hour Explain/demonstrate/
assignments/
presentations.
6 Pharmaceutical properties 1 hour Explain/demonstrate/
assignments/
presentations.
7 Physicochemical properties 1 hour Explain/demonstrate/
assignments/
presentations.
8 Physicochemical properties 1 hour Explain/demonstrate/
assignments/
presentations.
9 Physicochemical properties 1 hour Explain/demonstrate/
assignments/
presentations.
10 Drug metabolism 1 hour Explain/demonstrate/
assignments/
presentations.
11 Types of cofactors 1 hour Explain/demonstrate/
assignments/
presentations.
12 Pathways of metabolism 1 hour Explain/demonstrate/
assignments/
presentations.
13 Pathways of metabolism 1 hour Explain/demonstrate/
assignments/
presentations.
14 Factors affecting metabolism 1 hour Explain/demonstrate/
assignments/
35
presentations.
15 Factors affecting metabolism 1 hour Explain/demonstrate/
assignments/
presentations.
16 Drug biotransformation pathway 1 hour Explain/demonstrate/
assignments/
presentations.
17 Human hepatic cytochrome P450
Enzyme system
1 hour Explain/demonstrate/
assignments/
presentations.
18 Human hepatic cytochrome P450
Enzyme system (components)
1 hour Explain/demonstrate/
assignments/
presentations.
19 Human hepatic cytochrome P450
Enzyme system (classification)
1 hour Explain/demonstrate/
assignments/
presentations.
20 Cytochrome P450 isoforms
Metabolizing drugs
1 hour Explain/demonstrate/
assignments/
presentations.
21 Induction and inhibition of
cytochrome P450 isoforms
1 hour Explain/demonstrate/
assignments/
presentations.
22 Induction and inhibition of
cytochrome P450 isoforms
1 hour Explain/demonstrate/
assignments/
presentations.
23 Phase I biotransformation pathway 1 hour Explain/demonstrate/
assignments/
presentations.
24 Phase I biotransformation pathway 1 hour Explain/demonstrate/
assignments/
presentations.
25 Phase II biotransformation pathway 1 hour Explain/demonstrate/
assignments/
presentations.
26 Phase II biotransformation pathway 1 hour Explain/demonstrate/
assignments/
presentations.
27 Toxicology 1 hour Explain/demonstrate/
assignments/
presentations.
28 Systemic Toxicology 1 hour Explain/demonstrate/
assignments/
presentations.
29 Systemic Toxicology 1 hour Explain/demonstrate/
assignments/
presentations.
36
30 Pharmacogenetics 1 hour Explain/demonstrate/
assignments/
presentations.
31 Pharmacogenetics 1 hour Explain/demonstrate/
assignments/
presentations.
32 Pharmacogenetics 1 hour Explain/demonstrate/
assignments/
presentations.
33 Focuses on various drug classes; their
biochemistry, pharmacology,
mechanism of action, and toxicology
(disease state management).
1 hour Explain/demonstrate/
assignments/
presentations.
34 Focuses on various drug classes; their
biochemistry, pharmacology,
mechanism of action, and toxicology
(Chemotherapeutic agents)
1 hour Explain/demonstrate/
assignments/
presentations.
35 Focuses on various drug classes; their
biochemistry, pharmacology,
mechanism of action, and toxicology
(Analgesics, CVS).
1 hour Explain/demonstrate/
assignments/
presentations.
36 Focuses on various drug classes; their
biochemistry, pharmacology,
mechanism of action, and toxicology
(Antimicrobials, CNS).
1 hour Explain/demonstrate/
assignments/
presentations.
37 Focuses on various drug classes; their
biochemistry, pharmacology,
mechanism of action, and toxicology
(hormonal system).
1 hour Explain/demonstrate/
assignments/
presentations.
38 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
39 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
40 Presentation/test/assignments by 1 hour Assignments/
37
students presentations.
Text and Reference Books Advance Organic Chemistry: Part B. Reactions and Synthesis Carey, 4th Edition, Publisher
Kluwer, Academic Press (2011)
Burger‟s Medicinal Chemistry and Drug Discovery, edited by E.Wolf , 6th Edition , Wiley- Inter
Sciences, New York (2003)
Comprehensive Medicinal Chemistry Hansch C.M Sammes P.G. and Taylor J.B and David J.
Triggle , Pergomon Press Amsterdam (2007)
Foye‟s Principle of Medicinal Chemistry. David Lamke A. Williams, 6th Edition, William and
Wilkim , New York (2008).
Introduction to Medicinal Chemsitry; How drug act and why, by Alex Gringauze Wiley VCH Inc,
New York (1997)
Principles of Medicinal Chemistry William O. Foye, Thomaas L. Lemke and David A. Williams
6th Edition (2008).
Principles of Modern Chemistry, A guide to advanced study by W.F. Forbes and W.J Orville –
Thomas.
Remington‟s Pharmaceutical Sciences, 17th Edn., Mack Publishing Co., Easton , Pennsylvania
(1985).
The British Pharmacopoeia, British Pharmacopoea Commission, The Stationary Office London
(2005).
United States Pharmacopoeia, United States Pharmacopoeial Convention , Inc., Twinbrook
Parkway S P, Rockville, MD (2005).
PCH 704- ELECTROANALYTICAL AND CHROMATOGRAPHIC
TECHNIQUE (Major- IV)
Course Objective:
The primary objective of this course is to provide an overview of modern
chromatographic separation techniques as HPLC, TLC, GC. The theory of commonly
used separation mechanisms will be introduced, current instrumentation will be
explained, and applications from various areas will be presented to illustrate the benefits
of and problems associated with using chromatography as analytical technique.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1
Introduction to chromatographic
technique
1 hour Explain/demonstrate/
assignments/
presentations.
2 Principle of chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
3 Principle of chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
4 Application of chromatography 1 hour Explain/demonstrate/
38
assignments/
presentations.
5 Mode of chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
6 Normal phase chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
7 Reverse phase chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
8 Types of chromatographic technique 1 hour Explain/demonstrate/
assignments/
presentations.
9 Adsorption chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
10 Partition chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
11 Normal chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
12 Reverse chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
13 Size Exclusion chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
14 Ion Exchange chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
15 Anion chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
16 Cation chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
17 Affinity chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
18 Thin layer chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
19 Thin layer chromatography 1 hour Explain/demonstrate/
assignments/
39
presentations.
20 Column chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
21 Column chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
22 Column chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
23
Gas-liquid chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
24 Gas-liquid chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
25 Gas-liquid chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
26 Gas-liquid chromatography 1 hour Explain/demonstrate/
assignments/
presentations.
27
High performance thin layer liquid
chromatography
1 hour Explain/demonstrate/
assignments/
presentations.
28 High performance thin layer liquid
chromatography
1 hour Explain/demonstrate/
assignments/
presentations.
29 High performance thin layer liquid
chromatography
1 hour Explain/demonstrate/
assignments/
presentations.
30 High performance liquid 1 hour Explain/demonstrate/
assignments/
presentations.
31 High performance liquid 1 hour Explain/demonstrate/
assignments/
presentations.
32 High performance liquid 1 hour Explain/demonstrate/
assignments/
presentations.
33 High performance liquid 1 hour Explain/demonstrate/
assignments/
presentations.
34 Solvent system/ mobile phase,
types, polarity etc
1 hour Explain/demonstrate/
assignments/
presentations.
40
35 Types of column use in
chromatography
1 hour Explain/demonstrate/
assignments/
presentations.
36 Types of column use in
chromatography
1 hour Explain/demonstrate/
assignments/
presentations.
37 Application of new
chromatographic techniques in
pharmacy
1 hour Explain/demonstrate/
assignments/
presentations.
38 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
39 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
40 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
Text and Reference Books Veronika R. Meyer, 2010, Practical High-Performance Liquid Chromatography, Wiley-
Blackwell [ISBN: ISBN:978-0470682173]
Harold M. McNair, James M. Miller, 2009, Basic Gas Chromatography, Wiley-Blackwell [ISBN:
ISBN:0470439548]
Judith F. Rubinson, Kenneth A. Rubinson 1998, Contemporary chemical analysis, Prentice Hall
Upper Saddle River, NJ [ISBN: ISBN:0135193311]
R. A. Day, Jr., A. L. Underwood 1991, Quantitative analysis, Prentice Hall Englewood Cliffs, N.J.
[ISBN: ISBN:0137471556]
n/a, Robert E. Ardrey, 2003, Liquid chromatography-mass spectrometry, J. Wiley, New York
[ISBN: ISBN:0471498017]
Burger‟s Medicinal Chemistry and Drug Discovery, edited by E.Wolf , 6th Edition , Wiley- Inter
Sciences, New York (2003)
Foye‟s Principle of Medicinal Chemistry. David Lamke A. Williams, 6th Edition, William and
Wilkim , New York (2008).
Remington‟s Pharmaceutical Sciences, 17th Edn., Mack Publishing Co., Easton , Pennsylvania
(1985).
The British Pharmacopoeia, British Pharmacopoea Commission, The Stationary Office London
(2005).
United States Pharmacopoeia, United States Pharmacopoeial Convention , Inc., Twinbrook
Parkway S P, Rockville, MD (2005).
Analytical Application of spectroscopy, Creaser C.S. and Davies A.M.C (Eds) Royal Society of
Chemistry, London (1990)
Analytical Chemistry in GMP Environment, Miller J.M and Crowther , J.B Wiley, New York
(2000).
Instrumental Methods of Cemical Analysis, 5th Edition, Golden W. Evings Mc Graw Hill London
(1985)
41
Practical Absorption Spectrometry, Knowles and Brugess C. (Eds). Chapman and Hall, London
(1984).
Principles of Instrumental Analysis, 5th edition, Skog Holter and Nieman (2000).
Skoog D.A and West D.M. Principles of Instrumental Analysis 2nd Edition, Chapters 18-22 Holt-
Saunders, Philadelphia (1980).
Course Title
PCH 706- MOLECULAR MODELING AND COMPUTATIONAL
CHEMISTRY (Major-V )
Course Objective
The purpose of this course is to provide a basic and practical knowledge and
understanding of the various methods used in Molecular Modelling computer programs,
and to provide hands-on experience with a few programs by working through a number
of assignments including quantum chemistry (Gaussian) and molecular mechanics
softwares.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction to Molecular modeling
and computational chemistry
1 hour Explain/demonstrate/
assignments/
presentations.
2 Introduction to Molecular modeling
and computational chemistry
1 hour Explain/demonstrate/
assignments/
presentations.
3
Importance in drug designing. 1 hour Explain/demonstrate/
assignments/
presentations.
4 Application of molecular modeling
and computational chemistry in drug
designing.
1 hour Explain/demonstrate/
assignments/
presentations.
5 Application of molecular modeling
and computational chemistry in drug
designing.
1 hour Explain/demonstrate/
assignments/
presentations.
6
Use of different softwares and their
application in computational
1 hour Explain/demonstrate/
assignments/
presentations.
42
chemistry.
7 Computational chemistry approaches 1 hour Explain/demonstrate/
assignments/
presentations.
8 Computing the energy system of the
model
1 hour Explain/demonstrate/
assignments/
presentations.
9 ab initio method 1 hour Explain/demonstrate/
assignments/
presentations.
10 Density functional theory 1 hour Explain/demonstrate/
assignments/
presentations.
11 Semiemperical molecular orbital
methods
1 hour Explain/demonstrate/
assignments/
presentations.
12 Molecular mechanics 1 hour Explain/demonstrate/
assignments/
presentations.
13 AMBER 1 hour Explain/demonstrate/
assignments/
presentations.
14 CHARMM & CVFF 1 hour Explain/demonstrate/
assignments/
presentations.
15 Molecular Dynamics simulation 1 hour Explain/demonstrate/
assignments/
presentations.
16 Molecular Dynamics simulation 1 hour Explain/demonstrate/
assignments/
presentations.
17 Test (practice and handling of
software)
1 hour Explain/demonstrate/
assignments/
presentations.
18 Parameters 1 hour Explain/demonstrate/
assignments/
presentations.
19 Parameters 1 hour Explain/demonstrate/
assignments/
presentations.
20 Molecular Mechanics, 1 hour Explain/demonstrate/
assignments/
presentations.
21 Molecular Mechanics, 1 hour Explain/demonstrate/
assignments/
43
presentations.
22 Energy Minimization, 1 hour Explain/demonstrate/
assignments/
presentations.
23 Energy Minimization, 1 hour Explain/demonstrate/
assignments/
presentations.
24 Conformational Analysis 1 hour Explain/demonstrate/
assignments/
presentations.
25 Conformational Analysis 1 hour Explain/demonstrate/
assignments/
presentations.
26 Protein X-ray Crystallography and
Graphic Display
1 hour Explain/demonstrate/
assignments/
presentations.
27 Protein X-ray Crystallography and
Graphic Display
1 hour Explain/demonstrate/
assignments/
presentations.
28 Docking, Dynamics, 1 hour Explain/demonstrate/
assignments/
presentations.
29 Docking, Dynamics, 1 hour Explain/demonstrate/
assignments/
presentations.
30 Docking, Dynamics, 1 hour Explain/demonstrate/
assignments/
presentations.
31 QSAR 1 hour Explain/demonstrate/
assignments/
presentations.
32 QSAR 1 hour Explain/demonstrate/
assignments/
presentations.
33 Quantum 1 hour Explain/demonstrate/
assignments/
presentations.
34 Quantum 1 hour Explain/demonstrate/
assignments/
presentations.
35 Properties of Molecules from
Quantum Mechanical Calculations
1 hour Explain/demonstrate/
assignments/
presentations.
36 Properties of Molecules from
Quantum Mechanical Calculations
1 hour Explain/demonstrate/
assignments/
presentations.
44
37 Properties of Molecules from
Quantum Mechanical Calculations
1 hour Explain/demonstrate/
assignments/
presentations.
38 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
39 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
40 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
Text & Reference books
Guidebook on Molecular Modeling in Drug Design, Cohen, N. (Ed.), Academic Press, 1996
Essentials of Computational Chemistry: Theories and Models, Cramer, C.J. (Ed.), John Wiley & Sons,
2002
Handbook of Combinatorial Chemistry: Drugs, Catalysts, Materials (2-Vol. Set), Nicolaou, K.C.; Hanko,
R.; Hartwig, W. (Eds.), VCH Verlagsgesellschaft mbH, 2002
Combinatorial Strategies in Biology and Chemistry, Beck-Sickinger, A.; Weber, P. (Eds.), John Wiley &
Sons, 2002
Combinatorial Chemistry and Molecular Diversity in Drug Discovery, Gordon, E.M.; Kerwin, J.F. (Eds.),
Wiley-Liss, 1998
Combinatorial Library Design and Evaluation. Principles, Software, Tools, and Applications in Drug
Discovery, Ghose, A.K.; Viswanadhan, V.N. (Eds.), Marcel Dekker, 2001
Molecular Modeling and Simulation, Schlick, T. (Ed.), Springer Verlag, 2002
Molecular Modelling: Principles and Applications, Leach, A.R. (Ed.), Prentice Hall, 2001
Virtual Screening for Bioactive Molecules, Böhm, H.-J.; Schneider, G. (Eds.), VCH Verlagsgesellschaft
mbH, 2000
Virtual Screening: An Alternative or Complement to High Throughput Screening?, Klebe, G. (Ed.), Kluwer
Academic Publishers, 2000
Protein Structure. Determination, Analysis ,and Application for Drug Discovery, Chasman, D. (Ed.),
Marcel Dekker, 2003
Computer-Assisted Lead Finding and Optimization: Current Tools for Medicinal Chemistry, van de
Waterbeemd, H.; Testa, B.; Folkers, G. (Eds.), John Wiley & Sons, 1999
Advance Organic Chemistry: Part B. Reactions and Synthesis Carey, 4th Edition, Publisher Kluwer,
Academic Press (2011)
Burger‟s Medicinal Chemistry and Drug Discovery, edited by E.Wolf , 6th Edition , Wiley- Inter Sciences,
New York (2003)
Comprehensive Medicinal Chemistry Hansch C.M Sammes P.G. and Taylor J.B and David J. Triggle ,
Pergomon Press Amsterdam (2007)
Computer Aided drug design, Methods and application, by perum J. and Prospt C.L. (Marcel Dekker Inc).
Foye‟s Principle of Medicinal Chemistry. David Lamke A. Williams, 6th Edition, William and Wilkim ,
New York (2008).
Introduction to Medicinal Chemsitry; How drug act and why, by Alex Gringauze Wiley VCH Inc, New
York (1997)
Introduction to the principle of Drug Design and Action. Smith and William Smith and William‟s edited by
H. John Smith , 4th Edition, R C press, Taylor and Frances Group (2006) Kissinger P.T. and Heineman
W.R Laboratory Techniques in Electoanalytical Chemistry, Marcel, New York (1984).
45
Principles of Medicinal Chemistry William O. Foye, Thomaas L. Lemke and David A. Williams 6th
Edition (2008).
Principles of Modern Chemistry, A guide to advanced study by W.F. Forbes and W.J Orville – Thomas.
Remington‟s Pharmaceutical Sciences, 17th Edn., Mack Publishing Co., Easton , Pennsylvania (1985).
The British Pharmacopoeia, British Pharmacopoea Commission, The Stationary Office London (2005).
United States Pharmacopoeia, United States Pharmacopoeial Convention , Inc., Twinbrook Parkway S P,
Rockville, MD (2005).
Wikipedia entry
Computational Organic Chemistry, Steven Bachrach, Wiley, 2007, ISBN 978-0-471-71342-5.
This book also has a very interesting Blog, where the latest news and interesting publications in the area are
discussed.
Another blog on Computational Chemistry
Computational Chemistry Workbook: Learning Through Examples Thomas Heine, Jan-Ole Joswig, Achim
Gelessus ISBN: 978-3-527-32442-2, 2009.
Essentials of Computational Chemistry, Chris Cramer, Wiley, 2002.
Chemical Applications of Molecular Modelling, Jonathan Goodman, RSC, 1999. (ISBN 0-85404-579-1)
Molecular Modelling Workbook for Organic Chemistry, W. J. Hehre, A. J. Shusterman and J. E. Nelson,
1998.
Brief Guide to Molecular Mechanics and Quantum Chemical Calculations, W. J. Hehre, J. Yu, P. E.
Klunzinger and L. Lou, 1998.
Laboratory Book of Computational Organic Chemistry, W. J. Hehre, A. J. Shusterman, W. Wayne Huang,
1996.
Laboratory Exercises using HyperChem from Hypercube Educational Publications, M. L. Caffery, Caffery,
Dobosh and Richardson. (ISBN 1-896164-30-7)
Molecular Mechanics across Chemistry. Anthony Rappe and Carla Casewit (ISBN: 0-935702-77-6).
Molecular Modelling. Principles and Applications, A. R. Leach, Longman, 1996. ISBN 0-582-23933-8
Introduction to Computational Chemistry, by Frank Jensen, Wiley, 1999 (ISBN 0-471-98425-6).
Introduction to Theoretical Organic Chemistry and Molecular Modelling by William B. Smith. ISBN: 978-
0-471-18643-4
Encyclopaedia of Computational Chemistry, the definitive reference work for Computational Chemistry.
WATOC Congress, 1999, 2002, 2005, 2008, 2011.
Course Title
PCH 708- QUALITY CONTROL AND QUALITY ASSURANCE (Major-
VI )
Course Objective
Understand the meaning of quality in terms of the products and / or services provided by their organisation.
See their procedures as processes. Use statistical process control to help control and analyse processes. Get
more value from data obtained from internal quality assessment and external quality assessment
programmes. Set up an internal quality audit programme. Prepare audit checklists. Perform internal quality
audits. Raise non-compliance notes and implement corrective actions. Perform a customer survey.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
46
1
Introduction to QC and QA 1 hour Explain/demonstrate/
assignments/
presentations.
2 1. Overview of Quality, Foundations
of Quality Management, Overview
of Project Quality Management
1 hour Explain/demonstrate/
assignments/
presentations.
3 2. Meaning of Quality 1 hour Explain/demonstrate/
assignments/
presentations.
4 3. Quality assurance 1 hour Explain/demonstrate/
assignments/
presentations.
5 Concept and Basis of QC and QA 1 hour Explain/demonstrate/
assignments/
presentations.
6 Concept and Basis of QC and QA 1 hour Explain/demonstrate/
assignments/
presentations.
7 Quality Management System
(QMS)
1 hour Explain/demonstrate/
assignments/
presentations.
8 Accreditation 1 hour Explain/demonstrate/
assignments/
presentations.
9 Quality Management System
(QMS) Requirements (Organization,
Quality Management System)
1 hour Explain/demonstrate/
assignments/
presentations.
10 Quality Management System (QMS
Non-Conformances, Corrective and
Preventative Actions, Valid
Requirements)
1 hour Explain/demonstrate/
assignments/
presentations.
11 Quality Management System
(Document Control, Test Methods
and Method
Verification/Validation)
1 hour Explain/demonstrate/
assignments/
presentations.
12 Quality Management System
(Equipment, Measurement
Traceability and Quality Control
Checks, Personnel)
1 hour Explain/demonstrate/
assignments/
presentations.
13 Quality Management System
(Accommodation and
Environmental Conditions,
Sampling and Sample Handling,
Control of Data, Reports, Control of
Records)
1 hour Explain/demonstrate/
assignments/
presentations.
14 Quality Management System 1 hour Explain/demonstrate/
47
(Purchasing Services and Supplies,
Internal Audits, Management
Reviews)
assignments/
presentations.
15 Laboratory QA/QC Program
Requirements
1 hour Explain/demonstrate/
assignments/
presentations.
16
Valid Requirement (General,
Determining Valid Requirements,
Selecting Suitable Analytical
Methods, Regulatory
Considerations, Stating Valid
Requirements)
1 hour Explain/demonstrate/
assignments/
presentations.
17 Valid Requirement (Determining
Valid Requirements, Example for
the Comparison of Valid
Requirements to Several Proposed
Analytical Methods)
1 hour Explain/demonstrate/
assignments/
presentations.
18 Method Verification (General,
Verification of Calibration Curve
(Number of Standards,
Linear, non-linear, etc.), Verifying
Method Limit of Detection (LOD)
and Upper Limit of Quantification
(ULQ) Are Determined)
1 hour Explain/demonstrate/
assignments/
presentations.
19 Method Verification (Determining
Matrix Interference Using Spiked
Sample Analysis, Determining
Blank Interferences, Comparison to
Existing Methods, Method Re-
Verification)
1 hour Explain/demonstrate/
assignments/
presentations.
20 Basis for Control Charts (Control
Chart Theory, Analysis of Stable
Standards)
1 hour Explain/demonstrate/
assignments/
presentations.
21 Developing Control Charts;
(General, QC Check Concentration)
1 hour Explain/demonstrate/
assignments/
presentations.
22 Developing Control Charts;
(Collecting Data, Characterization
of Uncertainties, Central Tendency
and Dispersion)
1 hour Explain/demonstrate/
assignments/
presentations.
23 Developing Control Charts;
(Evaluating Data Normality,
Statistical Models, Tests for Non-
Normal Data)
1 hour Explain/demonstrate/
assignments/
presentations.
24 Developing Control Charts;
(Evaluating Data Precision,
1 hour Explain/demonstrate/
assignments/
48
Evaluating Data Accuracy, Setting
Limits and Centering Control
Charts)
presentations.
25 On-Going User of Control Charts 1 hour Explain/demonstrate/
assignments/
presentations.
26 On-Going User of Control Charts 1 hour Explain/demonstrate/
assignments/
presentations.
27 Layout of pharmaceutical industry
with special reference to QC and
QA
1 hour Explain/demonstrate/
assignments/
presentations.
28 Layout of pharmaceutical industry
with special reference to QC and
QA
1 hour Explain/demonstrate/
assignments/
presentations.
29 Layout of pharmaceutical industry
with special reference to QC and
QA
1 hour Explain/demonstrate/
assignments/
presentations.
30 Role and Responsibilities of QC and
QA department,
1 hour Explain/demonstrate/
assignments/
presentations.
31 Role and Responsibilities of QC and
QA department,
1 hour Explain/demonstrate/
assignments/
presentations.
32 Role and Responsibilities of QC and
QA department,
1 hour Explain/demonstrate/
assignments/
presentations.
33 Role and Responsibilities of QC and
QA department,
1 hour Explain/demonstrate/
assignments/
presentations.
34 Quality standards for
Pharmaceutical and formulated
products
1 hour Explain/demonstrate/
assignments/
presentations.
35 Quality standards for
Pharmaceutical and formulated
products
1 hour Explain/demonstrate/
assignments/
presentations.
36 Quality standards for
Pharmaceutical and formulated
products
1 hour Explain/demonstrate/
assignments/
presentations.
37 Quality standards for
Pharmaceutical and formulated
products
1 hour Explain/demonstrate/
assignments/
presentations.
38 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
49
39 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
40 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
Text and Reference Books Quality Assurance and Quality Control in the Analytical Chemical Laboratory: A Practical
Approach, Piotr Konieczka, Jacek Namiesnik, Taylor & Francis, 2009.
Analytical Measurements in Aquatic Environments, Jacek Namiesnik, Piotr Szefer, Taylor &
Francis, 2010.
Quality and Reliability in Analytical Chemistry,
George E. Baiulescu, Raluca-Ioana Stefan, Hassan Y. Aboul-Enein, Taylor &
Francis, 2010.
Statistics for the Quality Control Chemistry Laboratory/ Eamonn Mullins, Eamonn Mullins,
Royal Society of Chemistry, 2003.
Quality Assurance of Chemical Measurements, John Keenan Taylor, Lewis Publishers, 1987.
Quality Assurance in Analytical Chemistry, Elizabeth Prichard, Victoria Barwick, John
Wiley & Sons, 2007.
Quality Assurance in Analytical Chemistry: Applications in Environmental, Food and
Materials Analysis, Biotechnology, and Medical Engineering, Werner Funk, Vera
Dammann, Gerhild Donnevert, Wiley, 2007.
Quality Assurance in Analytical Chemistry: Training and Teaching, Bernd W.
Wenclawiak, Michael Koch, Evsovios Hadjicostas, Springer, 2010.
PCH 710- MACROMOLECULAR TARGET FOR DRUG DESIGNING
(Major-VII )
Course Objective
Drug–drug interactions have a significant impact upon patient response to medications,
potentially resulting in drug toxicity or lack of efficacy. In order to make sound clinical
judgements as to how to avoid or manage drug interactions it is critical that the
underlying mechanistic basis for these effects is elucidated. With a specific focus upon
the contribution of CYP450 and UGT drug metabolising enzymes we utilise a
combination of in silico, in vitro and in vivotechniques to gain an insight into the
molecular mechanisms that are responsible for observed clinically significant drug
interactions.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
50
1
2
Introduction to drug target 1 hour Explain/demonstrate/
assignments/
presentations.
3 Introduction to the concept of bio-
selectivity
1 hour Explain/demonstrate/
assignments/
presentations.
4
Biological structures
1 hour Explain/demonstrate/
assignments/
presentations.
5 Biological structures (Structure and
function of DNA)
1 hour Explain/demonstrate/
assignments/
presentations.
6 Biological structures (RNA and
proteins)
1 hour Explain/demonstrate/
assignments/
presentations.
7 Biological structures (Information
provided by 3D structures, General
methods of solving protein
structure)
1 hour Explain/demonstrate/
assignments/
presentations.
8 Biological structures (General
methods of solving protein
structure)
1 hour Explain/demonstrate/
assignments/
presentations.
9
Structural databases and formats
(overview)
1 hour Explain/demonstrate/
assignments/
presentations.
10 Structural databases and
formats (Protein Data Bank)
1 hour Explain/demonstrate/
assignments/
presentations.
11 Structural databases and
formats (Protein Data Bank)
1 hour Explain/demonstrate/
assignments/
presentations.
12 Structural databases and
formats (PubChem and
ZINC libraries)
1 hour Explain/demonstrate/
assignments/
presentations.
13 Structural databases and
formats (PubChem and
ZINC libraries)
1 hour Explain/demonstrate/
assignments/
presentations.
14 Structural databases and 1 hour Explain/demonstrate/
51
formats (Structural file
formats)
assignments/
presentations.
15
Protein-ligand docking
1 hour Explain/demonstrate/
assignments/
presentations.
16 Protein-ligand docking
(Representation of
macromolecules and
ligands)
1 hour Explain/demonstrate/
assignments/
presentations.
17 Protein-ligand docking
(Representation of
macromolecules and
ligands)
1 hour Explain/demonstrate/
assignments/
presentations.
18 Protein-ligand docking
(Representation of
macromolecules and
ligands)
1 hour Explain/demonstrate/
assignments/
presentations.
19 Protein-ligand docking
(Search methods and
flexibility of objects)
1 hour Explain/demonstrate/
assignments/
presentations.
20 Protein-ligand docking
(Search methods and
flexibility of objects)
1 hour Explain/demonstrate/
assignments/
presentations.
21 Protein-ligand docking
(Scoring methods)
1 hour Explain/demonstrate/
assignments/
presentations.
22 Protein-ligand docking
(Scoring methods)
1 hour Explain/demonstrate/
assignments/
presentations.
23 Protein-ligand docking
(Useful data in docking)
1 hour Explain/demonstrate/
assignments/
presentations.
24 Protein-ligand docking
(Useful data in docking)
1 hour Explain/demonstrate/
assignments/
presentations.
25 Protein-ligand docking
(DOCK6 approach of
1 hour Explain/demonstrate/
assignments/
52
protein-ligand docking) presentations.
26 Protein-ligand docking
(DOCK6 approach of
protein-ligand docking)
1 hour Explain/demonstrate/
assignments/
presentations.
27 Protein-ligand docking
(Virtual screening)
1 hour Explain/demonstrate/
assignments/
presentations.
28 Carbohydrates as drug
targets,
1 hour Explain/demonstrate/
assignments/
presentations.
29 Carbohydrates as drug
targets,
1 hour Explain/demonstrate/
assignments/
presentations.
30 Proteins as drug targets, 1 hour Explain/demonstrate/
assignments/
presentations.
31
Proteins drug targets, 1 hour Explain/demonstrate/
assignments/
presentations.
32 Proteins as drug targets, 1 hour Explain/demonstrate/
assignments/
presentations.
33 Lipids and nucleic acids as drug
targets
1 hour Explain/demonstrate/
assignments/
presentations.
34 Lipids and nucleic acids as drug
targets
1 hour Explain/demonstrate/
assignments/
presentations.
35 Drug action at enzymes 1 hour Explain/demonstrate/
assignments/
presentations.
36 Drug action at enzymes 1 hour Explain/demonstrate/
assignments/
presentations.
37
Drug action at receptors 1 hour Explain/demonstrate/
assignments/
presentations.
38 Drug action at receptors 1 hour Explain/demonstrate/
assignments/
presentations.
39 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
53
40 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
Text and Reference Books
The Design of drugs to macromolecular targets, C. R. Beddell, Wiley, 1992.
3D QSAR in Drug Design: Volume 3: Recent Advances, Hugo Kubinyi, Gerd Folkers, Yvonne C.
Martin, Springer, 1998.
Biopharmaceutical Drug Design and Development, Susanna Wu-Pong, Yongyut Rojanasakul,
Springer, 2008.
Drug Design Strategies: Quantitative Approaches, David J. Livingstone, Andrew M. Davis, David
E. Thurston, Royal Society of Chemistry, 2011.
Molecular Diversity in Drug Design, P.M. Dean, R.A. Lewis, Springer, 1999.
The Organic Chemistry of Drug Design and Drug Action, Richard B. Silverman, Academic
Press, 2004.
Course Title
PCH 712- SPECTROSCOPIC TECHNIQUES IN STRUCTURAL
ELUCIDATION (Major-VIII)
Course Objective
To give knowledge about the techniques and their importance. To make them useful tool
for structural elucidation. To explain the students about the study methodology of these
techniques
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1
Introduction of
Spectrophotometric
techniques
1 hour Explain/demonstrate/
assignments/
presentations.
2
UV-Visible Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
3
UV-Visible Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
4 UV-Visible Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
54
5 UV-Visible Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
6
UV-Visible Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
7 UV-Visible Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
8 UV-Visible Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
9 UV-Visible Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
10 UV-Visible Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
11 UV-Visible Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
12 Nuclear magnetic resonance
spectroscopy
1 hour Explain/demonstrate/
assignments/
presentations.
13 Nuclear magnetic resonance
spectroscopy
1 hour Explain/demonstrate/
assignments/
presentations.
14 Nuclear magnetic resonance
spectroscopy
1 hour Explain/demonstrate/
assignments/
presentations.
15 Nuclear magnetic resonance
spectroscopy
1 hour Explain/demonstrate/
assignments/
presentations.
16 Nuclear magnetic resonance
spectroscopy
1 hour Explain/demonstrate/
assignments/
presentations.
17 Nuclear magnetic resonance
spectroscopy
1 hour Explain/demonstrate/
assignments/
presentations.
18 Nuclear magnetic resonance
spectroscopy
1 hour Explain/demonstrate/
assignments/
presentations.
55
19 Nuclear magnetic resonance
spectroscopy
1 hour Explain/demonstrate/
assignments/
presentations.
20 Nuclear magnetic resonance
spectroscopy
1 hour Explain/demonstrate/
assignments/
presentations.
21 Nuclear magnetic resonance
spectroscopy
1 hour Explain/demonstrate/
assignments/
presentations.
22 Nuclear magnetic resonance 1 hour Explain/demonstrate/
assignments/
presentations.
23 Infra red Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
24 Infra red Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
25 Infra red Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
26 Infra red Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
27 Infra red Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
28 Infra red Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
29 Infra red Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
30 Infra red Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
31 Mass Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
32 Mass Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
33 Mass Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
56
34 Mass Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
35 Mass Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
36 Mass Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
37 Mass Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
38 Mass Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
39 Mass Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
40 Mass Spectroscopy 1 hour Explain/demonstrate/
assignments/
presentations.
Text and Reference Books
Organic spectroscopy By William Kemp
Spectroscopy of Organic compound By P. S. Kalsi
Spectroscopy By Dr. B. K. Sharma
Instrumental Analysis By Parimo
Molecular Structure and spectroscopy By G. Aruldhas
Analytical Spectroscopy By Raymond P. W. Scott
Classics in Spectroscopy By Stefan Berger
Organic Spectroscopic Analysis By Rosaleen J. Anderson
SEMESTER 3
Course Title
PCH 711-DIAGNOSTIC MEDICINAL CHEMISTRY (Major-IX)
57
Course Objective
The main purpose of these objectives is to provide the student basic knowledge of the
most frequently ordered clinical diagnostic laboratory tests, so that these students can
relate results of laboratory tests on patient charts to disease state. To know the major
factors, particularly the effects of medications, that may influence clinical tests, how they
influence the test results, and whether or not the effect may be clinically relevant.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction 1 hour Explain/demonstrate/
assignments/
presentations.
2 Biochemical specimens and normal
values
1 hour Explain/demonstrate/
assignments/
presentations.
3 Biochemical specimens and normal
values
1 hour Explain/demonstrate/
assignments/
presentations.
4 Electrolytes 1 hour Explain/demonstrate/
assignments/
presentations.
5 Electrolytes 1 hour Explain/demonstrate/
assignments/
presentations.
6 Immunoassays 1 hour Explain/demonstrate/
assignments/
presentations.
7 Immunoassays 1 hour Explain/demonstrate/
assignments/
presentations.
8 Blood Proteins 1 hour Explain/demonstrate/
assignments/
presentations.
9 Blood Proteins 1 hour Explain/demonstrate/
assignments/
presentations.
10 Blood Proteins 1 hour Explain/demonstrate/
assignments/
presentations.
11 Blood Enzymes 1 hour Explain/demonstrate/
assignments/
presentations.
58
12 Blood Enzymes 1 hour Explain/demonstrate/
assignments/
presentations.
13 Blood Enzymes 1 hour Explain/demonstrate/
assignments/
presentations.
14 Methods of enzymatic analysis and
Use of auto-analyzer in clinical
analysis.
1 hour Explain/demonstrate/
assignments/
presentations.
15 Endocrine function test 1 hour Explain/demonstrate/
assignments/
presentations.
16 Endocrine function test 1 hour Explain/demonstrate/
assignments/
presentations.
17 Hematology of RBCs 1 hour Explain/demonstrate/
assignments/
presentations.
18 Hematology of RBCs 1 hour Explain/demonstrate/
assignments/
presentations.
19 Hematology of WBCs 1 hour Explain/demonstrate/
assignments/
presentations.
20 Test 1 hour Explain/demonstrate/
assignments/
presentations.
21 Hematology of WBCs 1 hour Explain/demonstrate/
assignments/
presentations.
22 Hematology of Platelets 1 hour Explain/demonstrate/
assignments/
presentations.
23 Hematology of Platelets 1 hour Explain/demonstrate/
assignments/
presentations.
24 Electrolyte balance of serum 1 hour Explain/demonstrate/
assignments/
presentations.
25 Serum enzyme-lipid & glucose 1 hour Explain/demonstrate/
assignments/
presentations.
26 Serum enzyme-lipid & glucose 1 hour Explain/demonstrate/
assignments/
presentations.
59
27 Blood Chemistry-nitrogenous
compounds
1 hour Explain/demonstrate/
assignments/
presentations.
28 Blood Chemistry-nitrogenous
compounds
1 hour Explain/demonstrate/
assignments/
presentations.
29 Organ function test 1 hour Explain/demonstrate/
assignments/
presentations.
30 Organ function test 1 hour Explain/demonstrate/
assignments/
presentations.
31 Organ function test 1 hour Explain/demonstrate/
assignments/
presentations.
32 Test/ presentations 1 hour Explain/demonstrate/
assignments/
presentations.
33 Urinanalysis 1 hour Explain/demonstrate/
assignments/
presentations.
34 Urinanalysis 1 hour Explain/demonstrate/
assignments/
presentations.
35 OTC diagnostic 1 hour Explain/demonstrate/
assignments/
presentations.
36 OTC diagnostic 1 hour Explain/demonstrate/
assignments/
presentations.
37 Drug level monitoring 1 hour Explain/demonstrate/
assignments/
presentations.
38 Drug level monitoring 1 hour Explain/demonstrate/
assignments/
presentations.
39 Buffer and blood gasses 1 hour Explain/demonstrate/
assignments/
presentations.
40 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
Text and Reference Books
Clinical Chemistry, William J. Marshall (Ph. D.), Stephen Keith Bangert, Mosby, 2004
60
Tietz fundamentals of clinical chemistry, Carl A. Burtis, Edward R. Ashwood, Barbara
Border (PhD.), Norbert W. Tietz, 5th Edition, W.B. Saunders, 2001.
Clinical chemistry: made easy, Jeremy Hughes, Ashley Jefferson, M.D., Jonathan
Ashley Jefferson, Elsevier Science Health Science Division, 2008.
Delmar's Manual of Laboratory and Diagnostic Tests, Rick Daniels, Cengage Learning, 2003.
Davis's Comprehensive Handbook of Laboratory and Diagnostic Tests: With Nursing
Implications, Anne M. Van Leeuwen, Todd R. Kranpitz, Lynette S. Smith, F a Davis
Company, 2006.
Clinical Chemistry, Charles Henry Ralfe, BiblioBazaar, 2008.
Mosby's Manual of Diagnostic and Laboratory Tests, Kathleen Deska Pagana, Timothy
James Pagana, Elsevier Health Sciences, 2009.
Course Title
PCH 713- POLYMER CHEMISTRY (Major-X)
Course Objective
The purpose of this course is to give a thorough introduction into basic polymer
chemistry. The main focus of the course will be on synthetic polymers. The Polymer
Chemistry course builds upon the basic concepts of polymerisation introduced on day
one. Synthetic techniques in common use in both academic and industrial laboratories
formaking a wide variety of polymers will be covered. Emerging methodologies that
facilitategreater control over the final product, and as a consequence enable novel
polymerarchitectures, will also be considered. The gap between polymer chemistry and
polymer physics will be bridged by the introduction of some important thermodynamic
concepts that permit the behaviour of polymers to be understood.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1
Introduction to polymerization 1 hour Explain/demonstrate/
assignments/
presentations.
2 Types of polymerization 1 hour Explain/demonstrate/
assignments/
presentations.
3 Mechanism of polymerization 1 hour Explain/demonstrate/
assignments/
presentations.
4 Mechanism of polymerization 1 hour Explain/demonstrate/
assignments/
presentations.
61
5 Steriospecific polymerization 1 hour Explain/demonstrate/
assignments/
presentations.
6 Steriospecific polymerization 1 hour Explain/demonstrate/
assignments/
presentations.
7 Types of polymer isomerism 1 hour Explain/demonstrate/
assignments/
presentations.
8 Types of polymer isomerism 1 hour Explain/demonstrate/
assignments/
presentations.
9 Copolymerization 1 hour Explain/demonstrate/
assignments/
presentations.
10 Test 1 hour Explain/demonstrate/
assignments/
presentations.
11 Thermodynamic of polymer solution 1 hour Explain/demonstrate/
assignments/
presentations.
12 Thermodynamic of polymer solution 1 hour Explain/demonstrate/
assignments/
presentations.
13 Thermodynamic of polymer solution 1 hour Explain/demonstrate/
assignments/
presentations.
14 Thermoplastic and thermosetting
polymers
1 hour Explain/demonstrate/
assignments/
presentations.
15 Thermoplastic and thermosetting
polymers
1 hour Explain/demonstrate/
assignments/
presentations.
16 Industrial importance of
thermoplastic polymers
1 hour Explain/demonstrate/
assignments/
presentations.
17 Mechanical properties of polymers 1 hour Explain/demonstrate/
assignments/
presentations.
18 Mechanical properties of polymers 1 hour Explain/demonstrate/
assignments/
presentations.
19 Factors affecting mechanical
properties of polymers
1 hour Explain/demonstrate/
assignments/
presentations.
62
20 Presentations 1 hour Explain/demonstrate/
assignments/
presentations.
21 Polyurethanes 1 hour Explain/demonstrate/
assignments/
presentations.
22 Polyurethanes 1 hour Explain/demonstrate/
assignments/
presentations.
23 Properties of commonly used
polymers in pharmacy
1 hour Explain/demonstrate/
assignments/
presentations.
24 Properties of commonly used
polymers in pharmacy
1 hour Explain/demonstrate/
assignments/
presentations.
25 Properties of commonly used
polymers in pharmacy
1 hour Explain/demonstrate/
assignments/
presentations.
26 Properties of commonly used
polymers in pharmacy
1 hour Explain/demonstrate/
assignments/
presentations.
27 Testing and analysis of polymers 1 hour Explain/demonstrate/
assignments/
presentations.
28 Testing and analysis of polymers 1 hour Explain/demonstrate/
assignments/
presentations.
29 Instrumental technique for polymer
analysis
1 hour Explain/demonstrate/
assignments/
presentations.
30 Test 1 hour Explain/demonstrate/
assignments/
presentations.
31 Polymer stability 1 hour Explain/demonstrate/
assignments/
presentations.
32 Polymer stability 1 hour Explain/demonstrate/
assignments/
presentations.
33 Factors affecting stability of
polymers
1 hour Explain/demonstrate/
assignments/
presentations.
34 Synthesis of polymers 1 hour Explain/demonstrate/
assignments/
presentations.
63
35 Synthesis of polymers 1 hour Explain/demonstrate/
assignments/
presentations.
36 Degradation of polymers 1 hour Explain/demonstrate/
assignments/
presentations.
37 Degradation of polymers 1 hour Explain/demonstrate/
assignments/
presentations.
38 Degradation of polymers 1 hour Explain/demonstrate/
assignments/
presentations.
39 Application of polymers in Pharmacy 1 hour Explain/demonstrate/
assignments/
presentations.
40 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
Text and Reference Books
Principles of Polymer Chemistry, A. Ravve, Springer, 2012.
Principles of Polymer Chemistry, Paul J. Flory, Cornell University Press, 1953.
Introductory Polymer Chemistry, Gauri Shankar Misra, New Age International, 1993.
Polymer Science, Vasant R. Gowariker, N. V. Viswanathan, Jayadev Sreedhar, New
Age International, 1986.
TEXTBOOK OF POLYMER SCIENCE, Billmeyer, Wiley India Pvt. Limited, 2007.
Polymer Science Dictionary, Mark S. M. Alger, Springer, 1997.
Polymer science and technology, Joel R. Fried, Prentice Hall PTR, 1995.
Polymer Science : A Textbook, Ahluwalia V.K & Anuradha Mishra, Ane Books India,
2007.
Polymer Science: Recent Advances, Volume 2, I. S. Bhardwaj, Allied Publishers, 1994.
List of Faculty (full time/Visiting)
List of Full time Teaching Faculty at Faculty of Pharmaceutical
Sciences
Department of Pharmaceutical Chemistry:
1. Dr. Sana Shamim, B.Pharm., Ph.D
2. Dr. Mahwish Akhtar, B.Pharm., Ph.D
3. Dr. Moona Mehboob, B.Pharm., Ph.D
4. Dr. Kashif Shafique, MBBS , MPH , PhD
64
Department of Pharmaceutics: COURSE SCHEME-M.Phil
Semester Title of Course Course
Code
No. of Credit
Hrs.
Semester-1
Biostatistics (Core-I) PCE 701 3
Research Methodology (Core-II) PCE 703 3
Principles of Epidemiology (Core-III) PCE 705 3
Pharmaceutical Instrumentation Techniques
(Major-I)
PCE 707 2
Advanced physical Pharmacy (Major-II) PCE 709 2
13 credit hrs.
Semester Title of Course Course
Code
No. of Credit
Hrs.
Pharmaceutical microbiology (Major-III) PCE 702 2
Semester-2
Advanced Pharmaceutical Technology (Major- IV) PCE 704
3
Advanced Pharmacokinetics(Major- V) PCE 706 3
Pharmaceutical formulation design and
development (Major- VI)
PCE 708 3
Clinical Research in Pharmacy (Major-VII) PCE 710 2
Pharmaceutical marketing and management
(Major-VIII)
PCE 712 2
15 credit hrs.
Semester Title of Course Course
Code
No. of Credit
Hrs.
Semester-3 Advances in industrial pharmacy (Major-IX) PCE 711 3
65
. Pharmaceutical Quality Management Systems
(Major -X)
PCE 713 3
Journal Club (Core-IV) PCE 715
1
7 Credit hrs.
Semester Title of Course Course
Code
No. of Credit
Hrs.
Semester-4
.
Research work and Submission of thesis (Core-V)
PCE 714
6
6 Credit hrs.
Total Credit hours:
Semester-1 Semester-2 Semester-3 Semester-4 Total No. of
Credit Hrs.
13 15 7 6 41
Department of Pharmaceutics:
Course Details: For each course in the program that can be counted for credit provide 1-2 pages
specifying the following:
SEMESTER 1
66
PCE 701: BIOSTATISTICS: (CORE-I)
COURSE OBJECTIVE:
At end of the lecture, the student will be able to: 1. Define Data Organization (Grouping Data), (Graphs and Charts). 2. Describe Symbols and Summation Notation Sample and Population 3. Explain Measures of Central Tendency, Measures of Dispersion, Probability, Discrete
Probability Distribution, Binomial, Poisson and Normal Distributions, Sampling Distribution, Hypothesis Testing, One Sample Test, Two Sample Test (Independent Population) Two Sample Test (Paired And Proportion),Chi-Square Distribution
Analysis Of Variance One Way ANOVA, Two Way ANOVA
Regression, Multiple Regression And Correlation,Non Parametric Statistics
Lecture
No
Title of Lecture Durati
on
Teaching Method
1
Introduction of Data Organization
(Grouping Data): Introduction,
Biostatistics, Two Kind of Statistics,
Variable Types,
1 hr Lecture/ power
point
2
Frequency Distribution,Cumulative
Frequency Distribution, Frequency
Distribution of Continuous,
“ “
3 Relative Frequency Distribution, Stem
and Leaf Table
“ “
4
Data Organization (Graphs and Charts):
Graphic Presentation, Graphic
Presentation for Categorical Data,
“ “
5 Graphic Presentation for Quantitative
Data (Measurement),
“ “
6 Frequency Polygon, Pictograms,
Distortion the truth with Pictures
“ “
67
7 Symbols and Summation Notation
Sample and Population: Symbols,
Summation, Population and Sample,
Random Sampling
“ “
9 Simple Random Sampling, Stratified
Random Sampling,
“ “
10 Systematic Sampling, Cluster Sampling,
Parameter and Statistic
“ “
11 Measures of Central Tendency: Types of
Summary Measures, Measures of
Central Tendency,
“ “
12 The Mean (Arithmetic Mean), The
weighted Mean, The Median, The
Mode,
“ “
13 Measures of Central Tendency for
Grouped Data, The Mean, Median
and mode for the Grouped Data
“ “
14 Measures of Dispersion: Introduction,
The Range, The Mean Deviation, The
Variance,
“ “
15 Standard Deviation, The Coefficient of
Variation, Measures of Dispersion for
Grouped Data
“ “
16 Probability : Introduction ,Some
Definitions, Classical Probability,
“ “
17 Relative Frequency Probability, Notation
and Graphical Presentation of Events
“ “
68
18 Discrete Probability Distribution: Discrete
Random Variable,
“ “
19 Probability Distribution of Discrete
Random Variable.
“ “
20 Binomial, Poisson and Normal
Distributions: Bernoulli Trials,
Binomial Distribution,
“ “
21 Poisson Distribution, Normal Distribution,
Standard Normal Distribution
“ “
22
Sampling Distribution: Introduction,
Population of Samples Means,
“ “
23 Properties of populations of Sample
Means,
Properties of Distribution of Sample
Means, Central Limit Theorem
“ “
24 Estimating Means (Large Sample):
Estimating Mean, Confidence Interval
Estimate, Confidence Interval for the
Population Mean μ
“ “
25 Determination of Sample Size for
Estimating Means, Confidence
Interval for Population Mean (Small
Samples), Confidence Interval for
Population Mean μ
“ “
26 Small Interval, σ Known, T Distribution,
Confidence Interval for μ, Small
Sample, σ Unknown,
“ “
69
27 Confidence Interval for Population
Proportion (Large Sample), The
Sampling Distribution of a
proportion,
“ “
28 Determining the sample Size for
Estimating Proportion
“
29 Hypothesis Testing: Introduction, Some
Definition, Hypothesis Testing
Procedure, Hypothesis Testing for a
Population Mean (Large Samples)
“ “
30
One Sample Test
Two Sample Test (Independent
Population)
“ “
31 Two Sample Test (Paired And Proportion)
Chi-Square Distribution
“ “
32 Analysis Of Variance One Way ANOVA,
Two Way ANOVA
“ “
33 Non Parametric Statistics Sign Test,
Wilcoxon
Signed Rank Test, Mann Whitney Test
The Kruskal Wallis H Test
“ “
Text and Reference Books 1). Daniel W. W. Bio Statistics, Foundation for Analysis in Health Sciences. 3rd Edition,1983.
2). Zar. J. H. Bio-Statistical analysis, Francis Hall, N. J. USA.
3). Nilton, J. S. and Tsokes, J.D. Statistical Methods in Biological and Health Sciences, Me.
Grew-Hill,1983.
70
4). Chaudhry SA. And Kamal S. Introduction to Statistical Theory. Part-I and Part-II, Ilmi
Kitab Khana, Urdu Bazar Lahore, 1996.
5). Sunmels M. Statistics for the life sciences, Dellen Pub. Co. SF. USA, 1991.
6). Walpole RF. Introduction to Statistics, Macmillam Pub.Co. NY.1982.
PCE 703: RESEARCH METHODOLOGY (CORE-II)
COURSE OBJECTIVES:
At the end of the lecture, the student will be able to:
Define Concept of Research,Foundation of Hypothesis, Criteria of Good, Research Literature
Review. Explain Design of Experiment, Selection and preparation of tools for data collection,
Practicalities of data collection.
Demonstrate Presentation skills & Writing skills
Lecture
No
Title of Lecture Durati
on
Teaching Method
1
Concept of Research and its Approaches/
Scientific approaches/ Research
Terminologies.
1 hour Lecture/ power
point
2 Foundation of Hypothesis / How to do
Research Project/ Research on human
Specimens.
“ “
3 Criteria of Good Research / Research and
Quality Assurance.
“ “
71
4 Criteria of Good Research / Research and
Quality Assurance.
“ “
5 Literature Review I: Efficient Use of
Computers and Internet : Search
engines, digital libraries, E-databases,
archives
“ “
6 Literature Review I: Efficient Use of
Computers and Internet : Search
engines, digital libraries, E-databases,
archives
“ “
7 Literature Review II: Selection of research
problem; Research Journals,
Professional Societies, Conferences,
Scientific meetings, Workshops
“ “
8 Design of Experiment: Scientific
Study/Research Design.
“ “
9 Design of Experiment: Scientific
Study/Research Design.
“ “
10 Variables and its types. “ “
11 Variables and its types “ “
12 Selection and preparation of tools for
data collection, Practicalities of data
collection
“ “
13 Selection and preparation of tools for
data collection, Practicalities of data
collection
“ “
14 Sampling & Techniques “ “
15 Sampling & Techniques “ “
16 Processing and data analysis (statistical
approaches).
“ “
72
17 Processing and data analysis (statistical
approaches).
“ “
18 Analysis and interpreting of findings “ “
19 Analysis and interpreting of findings
20 Research Misconduct: Fraudulent research,
Plagiarism, retraction and cleansing, legal
burden.
Research Ethics/Informed Consent:
Confidentiality, deception, de-hoaxing and
desensitization
“ “
21 Scientific Integrity: Precision, reporting,
credits, authorship, mentoring Critical.
“ “
22 Evaluation of Research: Accuracy, precision,
reproducibility (stability and objectivity),
reliability,
“ “
23 quality, originality, bias and distortion, non-deliberate bias, sampling bias.
“ “
24 Communication of Science: Communication & Presentation skills: Oral: Technical Presentation, Keynote address, invited lectures, popular lecture
“ “
26 Communication of Science: Communication & Presentation skills: Oral: Technical Presentation, Keynote address, invited lectures, popular lecture
“ “
27 Writing skills: Language, diction, and contemporary style, data presentation and documentation/ Thesis writing /
“ “
28 Guidelines for synopsis/ thesis writing) How to present articles in ‘journal Club’.
“ “
29 Publication: Paper, audience and journal, basic structure of research paper, full-
“ “
73
length paper, short communications & notes,
30 case report, review and case series analysis, editorial, book review, letter to editor; refereeing process Editor’s role and impact factor.
31 Research Organizations: International & national: of USA, UK, Germany and Japan, Pakistan (PSF/ HEC/PMRC); Writing Research Proposal / Grant agencies.
“ “
32 Research Organizations: International & national: of USA, UK, Germany and Japan, Pakistan (PSF/ HEC/PMRC); Writing Research Proposal / Grant agencies.
33 Research Organizations: International & national: of USA, UK, Germany and Japan, Pakistan (PSF/ HEC/PMRC); Writing Research Proposal / Grant agencies.
“ “
34 Research Proposal: components, research economics, budgeting relevance to significance of research objectives
“ “
PCE 705: PRINCIPLES OF EPIDEMIOLOGY (Core-III)
COURSE OBJECTIVES:
At the end of the lecture, the student will be able to:
Define Epidemiology, disease Transmission.
Explain Measuring the occurrence of disease: Morbidity and Mortality, Assessing the Validity and
Reliability of diagnostic and screening tests.
Identify the roles of genetic and environmental factors in disease causation,
Evaluate health services by Epidemiology.
Lecture
No
Title of Lecture Durati
on
Teaching Method
74
1
Introduction
1 hour Lecture/ power
point
2 The dynamics of disease Transmission
“ “
3 The dynamics of disease Transmission
“ “
4 Measuring the occurrence of disease:
Morbidity and Mortality
“ “
5 Measuring the occurrence of disease:
Morbidity and Mortality
“ “
6 Measuring the occurrence of disease:
Morbidity and Mortality
7 Assessing the Validity and Reliability of
diagnostic and screening tests
“ “
8 Assessing the Validity and Reliability of diagnostic
and screening tests
“ “
9 Assessing the Validity and Reliability of diagnostic
and screening tests
“ “
10 Understanding biases and confounding “ “
11 Understanding biases and confounding “ “
12 Cohort Studies “ “
13 Cohort Studies “ “
14 Case-Control Studies and other study designs “ “
15 Comparing Cohort and Case-Control Studies “ “
16 Comparing Cohort and Case-Control Studies “ “
17 Indentifying the roles of genetic and
environmental factors in disease causation
“ “
18 Indentifying the roles of genetic and
environmental factors in disease causation
“ “
75
19 Using Epidemiology to evaluate health services “ “
20 Using Epidemiology to evaluate health services “ “
21 The epidemiologic approach to evaluating
screening programs
“ “
22 Epidemiology and public policy “ “
23 Epidemiology and public policy “ “
24 Measure of association I (Relative risk/odds ratio/
standardized mortality ratios/Attributable risk)
“ “
25 Measure of association I (Relative risk/odds ratio/
standardized mortality ratios/Attributable risk)
26 Ethical and professional issues in Epidemiology “ “
27 Ethical and professional issues in Epidemiology “ “
28 Investigation of disease outbreak “ “
29 Investigation of disease outbreak “ “
30 Causal inference “ “
31 Causal inference “ “
PCE 707 Pharmaceutical Instrumentation Techniques (Major-I)
Course Objective At the end of this course students will be able to.
Outline different commonly used analytical techniques use for drug analysis.
Demonstrate working and operation of Atomic adsorption and emission spectroscopy.
Propose working and operation of UC, IR, FT-IR and FT-NIR spectrophotometer.
Explain analysis of drugs using mass spectroscopy.
Demonstrate NMR. spectroscopy and explain its use in drug analysis.
Explain basic principles of liquid and gas chromatography
Propose operating procedure for ion exchange, ion pair and size exclusion chromatography.
76
Syllabus breakdown in lectures
Lecture
No
Title of Lecture Duration Teaching Method
1 UV, IR, FT-IR, FT-NIR PPT slides/white
board
2 Flourimetry PPT slides/white
board
3 Atomic absorption and atomic emission
spectroscopy.
PPT slides/white
board
4 Nuclear Magnetic Resonance
Spectroscopy
PPT slides/white
board
5 Mass Spectrometry PPT slides/white
board
6 Basic principle, applications and recent
trends in chromatography.
HPLC, LCMS
GC, GCMS
HPTLC
Ion exchange chromatography
Ion pair chromatography
Size exclusion chromatography
PPT slides/white
board
Text and Reference Books 1). Lough W. J. High Performance liquid Chromatography, Blacki Academic Press, New York.
1996.
2). William Kemp, Organic Spectroscopy, Ellsi Horwood , London, 1990.
3). M. Aminuddin & Javed Iqbal, Theory and Practical of Chromatography, University grant
Commission, Islamabd-Pakistan (2000).
4). A. H. Beckett and J. B. Stennlake , Practical Pharmaceutical Chemistry Part-I and Part-II,
the aulton Press.London.
77
5). A. M. Knevel and F. E. Digangi, Jenkin’s Quantitative Pharmaceutical Chemistry MCdraw
Hill Books Company, New York.
6). A. Braithwaite and F.J. Smith, Chromatographic Methods, Chapman and Hill, London.
7). E. Heftmann, Chromatography, Von Nostrond Reinheld Co. New York, 1975.
8). A. Pryde and M. J. Gilbert, Applications of High Performance Liquid Chromatography,
Chapman & Hall, London, 1979.
9). E. Stahl, Thin Layer Chromatography, Springer-Verlag, Berlin, 1969.
10. R. Hamilton, Introduction to HPLC. P. A. Sewell. Chapman & Hall. London, 1982.
PCE 709 Advanced Physical Pharmacy (Major-II)
Course Objective
To determine the thermodynamics of drug dissolution.
To determine the osmotic properties of dissolved drugs.
To determine the partitioning of drug in different solvents and its impact on drug
dissolution and absorption.
To determine the ionization of drugs when added into a solvent.
To identify the use of surfactant and there physic-chemical characteristics.
To determine the kinetics of drug decomposition, drug interaction and incompatibilities
with excepient.
Syllabus breakdown in lectures
Lecture
No
Title of Lecture Duration
(hrs)
Teaching Method
1-3
Thermodynamic properties of
drug in solution
3 PPT slides/white
board
4-5 Osmotic properties of drug in
solution
3 PPT slides/white
board
6-7 Partitioning of drug between
miscible solvent
2 PPT slides/white
board
78
8 Diffusion of drug in solution 1 PPT slides/white
board
9-11 Ionization of drug in solution 3 PPT slides/white
board
12-20 Surfactants, micellization,
solubilization and their role
in formulation
development.
9 PPT slides/white
board
21-25 The chemical breakdown of
drugs
5 PPT slides/white
board
26-32 Kinetics of chemical
decomposition in solution
7 PPT slides/white
board
33-40 Physicochemical drug
interactions and
incompatibilities
8 PPT slides/white
board
Text and Reference Books 1). Martin, Physical Pharmacy, B.I Waverty Pvt, Dehli 4th Ed. 1994.
2). Cooper and Gunn’s Tutorial Pharmacy, CBS Publishers & Distributors, New Dehli, 1986.
3). Bentley’s, Pharmaceutics, All India Traveler Book Seller, New Dehli 1996.
4). Martin. P. Bustamante, P and Chun, Physical & Clinical Principal’s of Pharmaceutical
Science, A.H.C 4th Edition (1999), New York.
5). Martin A. M. N, Banker G.S. and Chun A.H.C Advance in Pharmaceutical Sciences.
Academic Press London. 1985.
6). Mill C.C. Casson N. Rheology of disperse system, Pergamon Press, New Dehli, 1975.
7). Rienger M and Scott-Blair. G. W Reology Academic Press London 1972.
8). Barry B. W. Advances in Pharmaceutical Sciences, Academic Press, London. 1990.
9). Sherman P. Emulsion Sciences. Academic Press, London 1972.
79
10). Martine A. Swarbrick J. and Cammatra A. Physical Pharmacy 3rd Ed. Lee & Febiger,
Philadelphia. 1983.
11). Attwood D. and Florence A. T. Surfactant System. Chapman and I tall Ltd. London, 1982.
12). Remington’s Pharmaceutical Sciences, Mack Publisher Company USA, 2001.
Semester II
PCE 702 Pharmaceutical Microbiology (Major III)
Course Objective
At the end of this course, students will be able to:
Describe the scope of Microbiology with reference to pharmaceutical sciences.
Identify the sources of microbial contamination in pharmaceutical processing.
Explain the use of antimicrobial agents in the pharmaceutical industry.
Understand the basic principles of fermentation technology, bioprocessing and microbial growth kinetics.
Discus microbial genetics and its manipulation.
Syllabus breakdown in lectures
Lecture
No
Title of Lecture Duration Teaching Method
1-8
Microbial contamination
Sources of contamination
Factors affecting microbial
growth
Microbial spoilage of
pharmaceuticals
8 PPT slides/white
board
9-14 Non antibiotic antimicrobial agents
Disinfectants
Antiseptics
6 PPT slides/white
board
80
Mode of action
15-22 Industrial fermentation of
pharmaceutical products
Fermentation technology
Microbial growth kinetics
Industrial microbiology
8 PPT slides/white
board
23-30 Control of contamination of raw
material and finished products.
8 PPT slides/white
board
31-40 Bacterial Genetics & Drug Resistance 10 PPT slides/white
board
Text and Reference Books 1). Jawetz Medical Microbiology and Immunology, 5th Ed. Churchill Livingstone, London,
1998.
2). W. B. Hugo & A. D. Russell, Pharmaceutical Microbiology, Black Well Science Ltd. London
6th Ed.1998.
3). Lippincott, Microbiology by Lippincott, William & Willkin, USA,2001.
4). Alcamo, Introduction to Microbiology, John Bartlett Publisher, 6th Ed.2003.
5).Collin and Lynes. Microbiological Methods, Vutterworth Heineman, Oxford 1995.
6). Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology. John Wiley
& sons, New York. 2000.
7). M. Mekallec, Microbiology. Essential and Application Mac Graw Hill. Inc, 2nd Ed.
8). Pelczar. Microbiology, MacGraw Hill . Inc,1996.
9). Perscott, Harley, Microbiology Second, Klein Wm. C. Brown Publisher. 2001
10). An introduction to Microbiology, Tortora, funkee, case, 9th Edition.
PCE 704 Advanced Pharmaceutical Technology (Major-IV)
Course Objectives
81
At the end of this course, students will be able to:
Design and develop sustained release formulations.
Understand the principles of targeted drug delivery.
Explain the delivery of drugs via transdermal route and the advancements associated with it.
Understand the use of liposomes for ocular and other drug delivery systems.
Explain the use of virus as vectors for delivery of genes.
Syllabus breakdown in lectures
Lecture
No
Title of Lecture Duration Teaching Method
1-5
Advanced concepts in the design,
development and production of
sustained release products.
5 PPT slides/white
board
6-9 Targeted drug delivery systems 4 PPT slides/white
board
10-14 Transdermal drug delivery systems 5 PPT slides/white
board
15-18 Implants and Inserts 4 PPT slides/white
board
19-22 Liposome based drug delivery 4 PPT slides/white
board
23-25 Microencapsulation 3 PPT slides/white
board
26-30 Advanced ocular drug delivery 5 PPT slides/white
board
31-34 Nanotechnology in drug delivery 4 PPT slides/white
board
35-37 Viral-based gene and drug delivery
systems
3 PPT slides/white
board
38-40 Advanced drug delivery devices 3 PPT slides/white
board
82
Text and Reference Books 1). Anya M. Hellery, Drug delivery and targeting. Taylor & Frances, London, 2001.
2). Joseph R. Robinson controlled drug delivery Marcel & Dakker Inc, New York, 2nd Ed.
1987.
3) T. V. Ramabhadran, Pharmaceutical design and development, Ellis Horwood, New
York.1994.
4). M. E. Aulton, Pharmaceutics: Science of dosage forms design, ELBS / Churchill
Livingston, London 1998.
5). Banker, Modern Pharmaceutics, Marchell Dakker Inc, New York, 1990.
6). John A. Bontempo, Development of Bio-Pharmaceutical Parenteral dosage forms,
Marchill, Dakker Inc, New York, 1997.
7). N. K. Jain Controlled and Novel drug delivery, publisher & Distributors, New Dehli, 1997.
8). Ansel, Pharmaceutical Dosage form and Drug Delivery System, Lee & Febiger, London,
1990.
9). AttaurRehman and M. I. Chaudry, Bioassay, techniques for drug development, CRC Press
LLs, USA, 2001
10). Pramod K. Gupta, Inject able drug development CRC, press LLC. USA, 1999.
11). H. John Smith, Introduction to the Principal of drug design and action CRC, Press LLC,
USA, 1998.
12).Rong Liu, Water Insoluble drug Formulation, CRC Press LLC, USA, 2000.
13).Peter Blaisdell. Twenty first Century Pharmaceutical Development. CRC Press LLC, USA,
2000.
14).Lachman L, Theory and Practice of Industrial Pharmacy, Lee & Febiger, Philadelphia, 3rd
Ed, 1986.
PCE 706 Advanced Pharmacokinetics (Major-V)
Course Objective At the end of this course, students will be able to:
Differentiate between compartmental and non-compartmental models.
Understand linear and nonlinear pharmacokinetics.
Apply PKPD model for drug development.
83
Apply the acquire knowledge of pharmacokinetics in clinical situations.
Understand the distribution of drug in to compartments after delivery of a sustained release product.
Analyze the biological fluid to determine the traces of drug metabolites in them.
Understand bioequivalence and its scope in the global pharmaceutical market.
Syllabus breakdown in lectures
Lecture
No
Title of Lecture Duration Teaching Method
1-6
Pharmacokinetics compartment
Models and non-
compartmental analysis
6 PPT slides/white
board
7-14 Linear and non-linear
Pharmacokinetics
8 PPT slides/white
board
15-22 Clinical Applications of
Pharmacokinetic
Parameters
8 PPT slides/white
board
23-29 Pharmacokinetic Basis of
Controlled Drug Delivery
7 PPT slides/white
board
30-35 Analysis of drugs/metabolites in
biological fluids like urine,
blood, tissues and
enzymatic analysis.
6 PPT slides/white
board
36-40 Bioavailability and
bioequivalence studies
5 PPT slides/white
board
Text and Reference Books 1).Leon Shargel, Applied Pharmacokinetics and Bio Pharmaceutics, Appleton & Lange New
York 4th Ed, 1999.
2).Malcoln Rouland, Thomous N. Tozer, Pharmacokinetics, William & Willkins, London, 1995.
3).Milo Gibaldi, Bio-Pharmaceutics and Clinical Pharmacokinetics, Marchel & Dakker Inc,
New York, 1982.
4).Gibbson and Skett. Introduction to Drug Metabolism, Champ & Hall, London, 1986.
84
5).Robert E. Notari, Bio-Pharmaceutics and clinical Pharmacokinetics, Marchel & Dakker Inc
New York, 1988.
6).Stephen H. Curry. Drug disposition and Pharmacokinetics. Black Well Scientific publishing,
Oxford, 1977.
7).Avraham Yacobi., Toxicokinetics, and New Drug Development. Paramount Press, New
York, 1989.
8).Serfraz Niazi, text book of Bio-Pharmaceutics and Clinical Pharmacokinetics, Appleton-
Century Crofts, NewYork, 1985.
9).P. Macheras, C. Reppas and J. B. Dressman. Bio-Pharmaceutics of orally administered
drugs, Wllis Horwood Limited, London 1995.
10).Albert P. Li, In-vitro approaches for evaluation of drug efficacy and toxicity, CRC. Press,
LLC, USA, 2004.
11).Ronald D. Schoenwald, Pharmacokinetics in drug discovery and Development, CRC,
Press, SLLC, USA, 2002.
12).Leon Shargel, Applied Pharmacokinetics and Bio Pharmaceutics, Appleton & Lange New
York 4th Ed, 1999.
2).Malcoln Rouland, Thomous N. Tozer, Pharmacokinetics, William & Willkins, London, 1995.
3).Milo Gibaldi, Bio-Pharmaceutics and Clinical Pharmacokinetics, Marchel & Dakker Inc,
New York, 1982.
4).Gibbson and Skett. Introduction to Drug Metabolism, Champ & Hall, London, 1986.
5).Robert E. Notari, Bio-Pharmaceutics and clinical Pharmacokinetics, Marchel & Dakker Inc
New York, 1988.
6).Stephen H. Curry. Drug disposition and Pharmacokinetics. Black Well Scientific publishing,
Oxford, 1977.
7).Avraham Yacobi., Toxicokinetics, and New Drug Development. Paramount Press, New
York, 1989.
8).Serfraz Niazi, text book of Bio-Pharmaceutics and Clinical Pharmacokinetics, Appleton-
Century Crofts, NewYork, 1985.
9).P. Macheras, C. Reppas and J. B. Dressman. Bio-Pharmaceutics of orally administered
drugs, Wllis Horwood Limited, London 1995.
85
10).Albert P. Li, In-vitro approaches for evaluation of drug efficacy and toxicity, CRC. Press,
LLC, USA, 2004.
11).Ronald D. Schoenwald, Pharmacokinetics in drug discovery and Development, CRC, Press,
SLLC, USA, 2002
PCE 708 Pharmaceutical formulation design and development (Major-VI)
Course Objective
At the end of this course, students will be able to:
Explain the procedure for preformulation studies and its application in over all drug development.
Apply the acquired knowledge to identify the most suitable dosage form for a particular drug and determine the stability of the dosage form.
Understand the order of reaction and shelf life prediction of formulated drugs.
Determine the environmental factors affecting the stability of a newly designed dosage form.
Define polymers and explain the criteria for selection of a particular dosage form for a specific formulation.
Syllabus breakdown in lectures
Lecture
No
Title of Lecture Duration Teaching Method
1-4 Pre-formulation studies 4 PPT slides/white
board
5-8 Statistical approach to
formulation
4 PPT slides/white
board
9-15 Selection of dosage form 7 PPT slides/white
board
16-22 Stability studies 7 PPT slides/white
board
23-29 Order of reaction and their
applications in predicting
shelf life and half-life of
Pharmaceutical
formulations.
7 PPT slides/white
board
86
30-34 Environmental factors affecting
stability
5 PPT slides/white
board
35-40 Polymers and Classification 6 PPT slides/white
board
Text and Reference Books 1). Anya M. Hellery, Drug delivery and targeting. Taylor & Frances, London, 2001.
2). Joseph R. Robinson controlled drug delivery Marcel & Dakker Inc, New York, 2nd Ed.
1987.
3) T. V. Ramabhadran, Pharmaceutical design and development, Ellis Horwood, New
York.1994.
4). M. E. Aulton, Pharmaceutics: Science of dosage forms design, ELBS / Churchill
Livingston, London 1998.
5). Banker, Modern Pharmaceutics, Marchell Dakker Inc, New York, 1990.
6). John A. Bontempo, Development of Bio-Pharmaceutical Parenteral dosage forms,
Marchill, Dakker Inc, New York, 1997.
7). N. K. Jain Controlled and Novel drug delivery, publisher & Distributors, New Dehli, 1997.
8). Ansel, Pharmaceutical Dosage form and Drug Delivery System, Lee & Febiger, London,
1990.
9). AttaurRehman and M. I. Chaudry, Bioassay, techniques for drug development, CRC Press
LLs, USA, 2001
10). Pramod K. Gupta, Inject able drug development CRC, press LLC. USA, 1999.
11). H. John Smith, Introduction to the Principal of drug design and action CRC, Press LLC,
USA, 1998.
12).Rong Liu, Water Insoluble drug Formulation, CRC Press LLC, USA, 2000.
13).Peter Blaisdell. Twenty first Century Pharmaceutical Development. CRC Press LLC, USA,
2000.
14).Lachman L, Theory and Practice of Industrial Pharmacy, Lee & Febiger, Philadelphia, 3rd
Ed, 1986.
87
PCE 710 Clinical research in Pharmacy (Major-VII)
Course Objective At the end of this course, students will be able to:
Evaluate the interaction between various drugs on a prescription and the types of these interactions.
Search the causes of these interactions.
Solve the problems related to these interactions.
Develop the skills required for efficient communication with patients.
Formulate total parenteral nutrition.
Develop an understanding about how to solve problems associated with specific medical conditions.
Solve the issues arising from poison administration.
Take part in the administration of clinical pharmacy at hospitals and community.
Syllabus breakdown in lectures
Lecture
No
Title of Lecture Duration Teaching Method
1-5
Latest developments and
advances in clinical
Pharmacy.
5 PPT slides/white
board
6-11 Efficient communication with
patients
6 PPT slides/white
board
12-16 Total Parenteral Nutrition 5 PPT slides/white
board
17-26 Problem Oriented Approach:
Cardiovascular disorders,
Renal diseases, Infectious
diseases and Respiratory
Diseases.
10 PPT slides/white
board
27-36 Specific drugs and poisons:
Diagnosis and treatment,
Antibiotics,
Antidepressants, Arsenic,
Benzodiazepines,
Analgesics, Calcium
10 PPT slides/white
board
88
antagonists, Digoxin,
Nitroglycerin and Cyanide.
37-40 Administration of clinical
pharmacy
4 PPT slides/white
board
Text and Reference Books 1). Roger Walker, Clinical Pharmacy & Therapeutics, Churchill Livingston, London, 3rd Ed.
2003.
2). Guard Paul, A Behavioral Approach to Pharmacy Practice, Black well , USA, 2000.
3). Herfindel Gourley, Clinical Pharmacy & Therapeutics, William & Wilkins, London. 1992.
4). A. J. Winfield, Pharmaceutical Practice, Churchill Livingstone, London, 2nd Ed. 1998.
5). Kavin Taylor, Pharmacy practice , Taylor & Francis, New York, 1998./
6). Deborah Rosenbaun, Clinical Research Coordinator Hand Book, 2nd Ed. Sarris on, Inc
North Carolina USA.
7). Simon Cook, Clinical, Studies Management a Practical Guide to Success, Sue Horwood
Publishing limited, West Sussex, UK.
8). Joseph T. Dipiro, Encyclopedia of Clinical Pharmacy. Mareel Dekker Publishing, 2003.
9). Joseph T. Dipiro, Encyclopedia of Clinical Pharmacy. Mareel Dekker Publishing, 2002.
10). Mellainie J. Rantucci, Pharmacist Tallding with Patient .1997.
11). Smith GDG and Aronson JK. Oxford Text Book of Chemical Pharmacology and Drug
Therapy Oxford University ,Press, UK. 1990.
12). Hasten P and Horn J. Drug Interaction. Lee & Febiger, Philadelphia. USA, 1989.
PCE 712 Pharmaceutical marketing and management (Major-VIII)
Course Objective At the end of this course, students will be able to:
Explain nature and principals of management.
Mention and describe types of pharmaceutical products and pharmaceutical market.
Explain the role of government in marketing control.
Disucs marketing, its evaluation and strategies.
Evaluate demand and sales targets
89
Explain HR management and related functions.
Discus employee evaluation and incentives.
Syllabus breakdown in lectures
Lecture
No
Title of Lecture Duration Teaching Method
1-2 Pharmaceutical products 2 PPT slides/white
board
3-6 Pharmaceutical market 4 PPT slides/white
board
7-10 Evaluation of the impact of marketing 4 PPT slides/white
board
11-13 Concept of governmental and internal
control on marketing.
3 PPT slides/white
board
14-17 Marketing strategy 4 PPT slides/white
board
18-22 Evaluation of demand 5 PPT slides/white
board
23-27 Sales volume and targets 5 PPT slides/white
board
28-30 Function of human resource
department
3 PPT slides/white
board
31-32 Personnel function, recruitment
and selections
2 PPT slides/white
board
33-34 Performance evaluations,
promotions, transfer,
training
2 PPT slides/white
board
35-36 Human resource management
and motivation
2 PPT slides/white
board
37-38 Leadership and supervision 2 PPT slides/white
board
90
39 Effective communication 1 PPT slides/white
board
40 Salary, incentives, benefits. 1 PPT slides/white
board
Text and Reference Books 1). M. Ahmed & N. I. Bukhari, Pharmaceutical Management and Marketing, Tariq Academy ,
Faisalabad, Pakistan, 2002.
2). C. Patrick Tharp & Pedro J. Lecca, Pharmacy management for students and Practitioners,
the C. V. Mosby Company, St.Louis, Toronto, London. 1979.
3). Harry A. Smith, Principles & Methods of Pharmacy Management, Tea & Febiger
Philadelphia, 1986
SEMESTER 3
PCE-711 Advances in industrial pharmacy (Major-IX)
Course Objective At the end of this course, students will be able to:
Explain the capacity considerations for pharmaceutical production
Discuss the criteria for design of sterile and non-sterile pharmaceutical manufacturing area.
Understand the designing of HVAC.
Discus packaging units, its design and containment.
Differentiate between pilot plant and scale up and the guidelines laid down by different agencies.
Understand the governmental policies for drug manufacturing and pharmaceutical regulatory affairs.
Discus novel dosage forms and their manufacture.
Syllabus breakdown in lectures
Lecture
No
Title of Lecture Duration Teaching Method
91
1-5 Capacities and production lines. 5 PPT slides/white
board
6-12 Design criteria for sterile and
non-sterile products
manufacturing units
7 PPT slides/white
board
13-18 Design and development of
packaging units
6 PPT slides/white
board
19-24 Process automation in
Pharmaceutical
manufacturing.
6 PPT slides/white
board
25-30 Pilot plant, scale up technique,
introduction to SUPAC
guidelines.
6 PPT slides/white
board
31-35 Drug regulatory affairs 5 PPT slides/white
board
36-40 A Brief study on formulation
and evaluation of
specialized pharmaceutical
dosage form
Dry syrup,
Topical gel,
Microemulsion,
dry powder,
Parenteral
5 PPT slides/white
board
Text and Reference Books 1).Lachman, Theory and Practice of Industrial Pharmacy, Varghese Publishing House,
Bombay, 1987.
2).Cooper and Gunn’s, Tutorial Pharmacy, CBS Publishers & Distributors, New Dehli, 1986.
3).Bentley’s Pharmaceutical Text Book, CBS Publishers & Distributors, New Dehli, 1986.
4).Remington’s Pharmaceutical Sciences, Mack Publishing Company, USA, 2001.
5).John Sharp, Good Pharmaceutical Manufacturing Practice, Rational and Compliance.
92
PCE- 713 Pharmaceutical Quality Management System. (Major-X)
Course Objective At the end of this course, students will be able to:
Explain and determine different biological assays.
Develop analytical method for the detection and analysis of different drugs.
Describe and perform different determination and tests (for weight/ml, water/moisture content loss on drying , identification tests, ash contents, alkalinity of glass , ointment valuation)
Know about appendices attached to B.P, B.P.C and U.S.P.
Interpret statistical calculation / method of QC chart s during manufacturing process.
Explain the concept of cGMP and GLP
Understand IQ, OQ, DQ and PQ and the principles of process validation.
Syllabus breakdown in lectures
Lecture
No
Title of Lecture Duration Teaching Method
1-7
Development of analytical
methods for drug analysis
7 PPT slides/white
board
8-16 Methods of analysis of common
excipients/ additives in
formulations.
9 PPT slides/white
board
17-24 Biochemical analysis of drugs 8 PPT slides/white
board
25-30 Microbiological assay of
antibiotics and vitamins.
6 PPT slides/white
board
31-33 Reference and working
standard
3 PPT slides/white
board
34-37 cGMP and GLP 4 PPT slides/white
board
93
38-40 Qualification and Validation 3 PPT slides/white
board
Text and Reference Books 1). A. H. Beckett and J. B. Stennlake, Practical Pharmaceutical Chemistry, Part-I and II. The
Alton Press, London.
2). A. M. Kneval and F. E Digangi, Jenkin’s, Quantitative Pharmaceutical Chemistry, Mac
Graw-Hill, Book Company, New York.
3). K. A. Connor’s, A text book of Pharmaceutical Analysis John – Wiley and Sons, New York.
4). A. Braithwaite and F. J. Smith, Chromatographic Methods, Chapman and Hall, London.
5). G. D. Christian, Analytical Chemistry, John Wiley and Sons, New York.
6). Karami A. Javaid, Pharmaceutical Quality Assurance in Class, Industry and Market, Aziz
Publishers, Lahore, Pakistan (1993).
7). Gil Bismuth and Shosh Neumann, Cleaning Validation, A Practical approach, CRC, Press
LLC, USA, 2003.
8). J. T. Carstersen and C. T. Rhodes, Drug Stability: Principles and Practices, 3rd Edition
(received and expanded) Mercel Decker, New York, 2000.
9). Sydney H. Willige, Good Manufacturing Practices for Pharmaceuticals. Marcel Dekker
Publishing.
10). Braun RE, Introduction to Instrumental Analysis, Mc Graw-Hill Book Co, NY, 1987.
List of Full Time Teaching Faculty at Faculty of Pharmaceutical
Sciences
Department of Pharmaceutics:
1. Dr. Hafiz M. Arshad, B. Pharm., M.Phil., PhD 2. Dr. Najia Raheem , B. Pharm., M.Phil., PhD. 3. Dr. Tariq Ali , B. Pharm., M.Phil., PhD.
94
4. Dr. Fakhsheena Anjum, B. Pharm., M.Pharm., PhD. 5. Dr. Kashif Shafique, MBBS , MPH , PhD
95
Department of Pharmacognosy: COURSE SCHEME-M.Phil
Title of Course Course Code No. of Credit Hrs.
Semester-I
Biostatistics (Core-I)
PCG 701
3
Research Methodology (Core-II)
PCG 703
3
Principles of Epidemiology (Core-III) PCG 705
3
Pharmacognostic Instrumentation Techniques
(Major I)
PCG 707
2
Science and Clinical Practice of Herbal Medicine
(Major II)
PCG 709
3
14 credit hrs.
Semester-II
Natural Products Drug Discovery (Major-III) PCG 702 3
Cosmeceuticals and Neutraceuticals (Major IV) PCG 704
3
Natural Toxicology (Major V) PCG 706
2
Biosynthesis of Natural Products (Major VI) PCG 708
2
Regulatory Affairs of Herbal Medicine
(Major VII)
PCG 710
2
96
Structure Elucidation of natural products (Major
VIII)
PCG 712
3
15 credit hrs.
Semester Title of Course Course Code No. of Credit Hrs.
Semester-3
.
Nutritional Herbology (Major IX)
PCG 711
3
Agricultural Pharmacy (Major X)
PCG 713
2
Journal Club (Core-IV) PCG 715
1
6 Credit hrs.
Semester-4
.
Research work and Submission of thesis (Core-V)
PCG 714
6
6 Credit hrs.
Total Credit hours:
Semester-1 Semester-2 Semester-3 Semester-4 Total No. of
Credit Hrs.
14 15 6 6 41
Department of Pharmacognosy:
SEMESTER-1
97
Course Title
PCG 701- BIOSTATISTICS (CORE-I)
Course Objective
This course is designed to give students experience and confidence in the design and
analysis of data within realistic biological research contexts. Students will gain basic practical
experience in collecting, displaying, summarizing, analyzing and interpreting biological data
in applied research contexts using standard statistical methods.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction of Data Organization
(Grouping Data)
1 hour Explain/demonstrate/
assignments/
presentations.
2 Data Organization (Graphs and Charts 1 hour Explain/demonstrate/
assignments/
presentations.
3 Symbols and Summation Notation
Sample and Population
1 hour Explain/demonstrate/
assignments/
presentations.
4 Measures of Central Tendency 1 hour Explain/demonstrate/
assignments/
presentations.
5 Measures of Dispersion 1 hour Explain/demonstrate/
assignments/
presentations.
6 Probability 1 hour Explain/demonstrate/
assignments/
presentations.
98
7 Probability 1 hour Explain/demonstrate/
assignments/
presentations.
8 Probability 1 hour Explain/demonstrate/
assignments/
presentations.
9 Discrete Probability Distribution: 1 hour Explain/demonstrate/
assignments/
presentations.
10 Discrete Probability Distribution: 1 hour Explain/demonstrate/
assignments/
presentations.
11 Binomial, Poisson and Normal
Distributions:
1 hour Explain/demonstrate/
assignments/
presentations.
12 Binomial, Poisson and Normal
Distributions:
1 hour Explain/demonstrate/
assignments/
presentations.
13 Sampling Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
14 Estimating Means (Large Sample 1 hour Explain/demonstrate/
assignments/
presentations.
15 Hypothesis Testing: One Sample Test 1 hour Explain/demonstrate/
assignments/
presentations.
16 Hypothesis Testing: One Sample Test 1 hour Explain/demonstrate/
assignments/
presentations.
17 Hypothesis Testing: One Sample Test 1 hour Explain/demonstrate/
assignments/
presentations.
99
18 Two Sample Test (Independent
Population)
1 hour Explain/demonstrate/
assignments/
presentations.
19 Two Sample Test (Independent
Population)
1 hour Explain/demonstrate/
assignments/
presentations.
20 Two Sample Test (Independent
Population)
1 hour Explain/demonstrate/
assignments/
presentations.
21 Two Sample Test (Paired And
Proportion)
1 hour Explain/demonstrate/
assignments/
presentations.
22 Two Sample Test (Paired And
Proportion)
1 hour Explain/demonstrate/
assignments/
presentations.
23 Two Sample Test (Paired And
Proportion)
1 hour Explain/demonstrate/
assignments/
presentations.
24 Chi-Square Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
25 Chi-Square Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
26 Chi-Square Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
27 Analysis Of Variance One Way ANOVA 1 hour Explain/demonstrate/
assignments/
presentations.
28 Analysis Of Variance One Way ANOVA 1 hour Explain/demonstrate/
assignments/
presentations.
100
29 Analysis Of Variance One Way ANOVA 1 hour Explain/demonstrate/
assignments/
presentations.
30 Analysis Of Variance Two Way ANOVA 1 hour Explain/demonstrate/
assignments/
presentations.
31 Analysis Of Variance Two Way ANOVA
1 hour Explain/demonstrate/
assignments/
presentations.
32 Factorial ANOVA 1 hour Explain/demonstrate/
assignments/
presentations.
33 Factorial ANOVA 1 hour Explain/demonstrate/
assignments/
presentations.
34 Regression, Multiple Regression
And Correlation
1 hour Explain/demonstrate/
assignments/
presentations.
35 Regression, Multiple Regression
And Correlation
1 hour Explain/demonstrate/
assignments/
presentations.
36 Non Parametric Statistics 1 hour Explain/demonstrate/
assignments/
presentations.
37 Non Parametric Statistics 1 hour Explain/demonstrate/
assignments/
presentations.
38 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
39 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
40 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
101
Text and Reference Books Heath, D. An Introduction to Experimental Design and Statistics for Biology, London, UCL Press, 1995.
Campbell, S. K. Flaws and Fallacies in Statistical Thinking, Prentice-Hall, 1974.
Fisher, R. A. The Design of Experiments. Hafner, 1971.
Gonick, L. and Smith, W. The Cartoon Guide to Statistics. Harper Perennial, 1993
Moses, L. E. Think and Explain with Statistics. Addison Wesley, 1986.
Salsburg, D. S. Understanding Randomness. Lecture Notes in Statistics, Vol. 6 Marcel Dekker, 1983.
Sokal, R. R. and F. J. Rohlf. Introduction to Biostatistics, 2nd
, 3ed. Freeman, 1987.
Zar, J. Biostatistical Analysis. Prentice Hall, 1984.
Course Title
PCG 703- RESEARCH METHODOLOGY (CORE-II)
Course Objective
The objectives of the course are:
To provide students with the tools and skills required to understand research terminology and
assess published research; to identify the types of methods best suited for investigating
different types of problems and questions, to design a research proposal and to begin initial
preparations for embarking on a new research project.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1
Introduction 1 hour Explain/demonstrate/
assignments/
presentations.
2
Research Objective
1 hour Explain/demonstrate/
assignments/
presentations.
102
3 Selection of the area of research
1 hour Explain/demonstrate/
assignments/
presentations.
4 Selection of the area of research
1 hour Explain/demonstrate/
assignments/
presentations.
5 Selection of research guide/supervisor
1 hour Explain/demonstrate/
assignments/
presentations.
6 Selection of research guide/supervisor
1 hour Explain/demonstrate/
assignments/
presentations.
7 Selection of topic/ problem
1 hour Explain/demonstrate/
assignments/
presentations.
8 Selection of topic/ problem
1 hour Explain/demonstrate/
assignments/
presentations.
9 Selection of topic/ problem
1 hour Explain/demonstrate/
assignments/
presentations.
10 Construction of a strong statement that
summarizes the selected topic.
1 hour Explain/demonstrate/
assignments/
presentations.
11 Construction of a strong statement that
summarizes the selected topic.
1 hour Explain/demonstrate/
assignments/
presentations.
12 Sources of information
1 hour Explain/demonstrate/
assignments/
presentations.
13 Books, journals/periodicals, old 1 hour Explain/demonstrate/
assignments/
103
testimonials.
presentations.
14 News papers, internet; proceedings of
conferences
1 hour Explain/demonstrate/
assignments/
presentations.
15 Seminars, workshops and training
programs; conversations
1 hour Explain/demonstrate/
assignments/
presentations.
16 Detail of Equipments/ Fields/ Area
1 hour Explain/demonstrate/
assignments/
presentations.
17 Type of Instruments: Models, make and
country of origin;
1 hour Explain/demonstrate/
assignments/
presentations.
18 Validation: reliability and accuracy 1 hour Explain/demonstrate/
assignments/
presentations.
19 Service centers, availability of supplies
and engineers; Environment: laboratory
conditions.
1 hour Explain/demonstrate/
assignments/
presentations.
20 Service centers, availability of supplies
and engineers; Environment: laboratory
conditions
1 hour Explain/demonstrate/
assignments/
presentations.
21 Plan of work 1 hour Explain/demonstrate/
assignments/
presentations.
22 Collection of material/authentication
1 hour Explain/demonstrate/
assignments/
presentations.
23 Collection of material/authentication
1 hour Explain/demonstrate/
assignments/
presentations.
104
24 Preliminary screening/pilot plan
1 hour Explain/demonstrate/
assignments/
presentations.
25 Preliminary screening/pilot plan
1 hour Explain/demonstrate/
assignments/
presentations.
26 Experimental: detailed procedure 1 hour Explain/demonstrate/
assignments/
presentations.
27 Experimental: detailed procedure 1 hour Explain/demonstrate/
assignments/
presentations.
28 Experimental: detailed procedure 1 hour Explain/demonstrate/
assignments/
presentations.
29 Places for practical work and resources
1 hour Explain/demonstrate/
assignments/
presentations.
30 Places for practical work and resources
1 hour Explain/demonstrate/
assignments/
presentations.
31 Places for practical work and resources
1 hour Explain/demonstrate/
assignments/
presentations.
32 Places for practical work and resources
1 hour Explain/demonstrate/
assignments/
presentations.
33 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
34 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
105
35 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
36 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
37 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
38 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
39 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
40 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
Text and Reference Books
Luker, K. (2010). Salsa dancing into the social sciences. Cambridge, MA: Harvard University Press. (ISBN 9780674048218).
Knight, P.T. (2002). Small-scale research. Thousand Oaks, CA: Sage Publications (ISBN-10: 0761968628 / ISBN-13: 978-0761968627).
Myers, Michael D. "Qualitative Research in Information Systems”, AISWorld Section on Qualitative Research, www.qual.auckland.ac.nz
Myers, Michael D., and David Avison (eds.). Qualitative Research in Information
Systems: A Reader. Sage Publications, 2002.
Lee, A.S., Liebenau, J. and DeGross, J.I. (eds.). Information Systems and Qualitative Research, Chapman and Hall, London, 1997.
Yin, Robert K. Case Study Research: Design and methods. Third edition. Sage Publications, 2003.
Walsham, G. Interpreting Information Systems in Organizations. John Wiley and Sons, Chichester, 1993.
Wolcott, H. Writing up Qualitative Research. Sage Publications, Thousands Oaks, CA, 1990.
PCG 705: EPIDEMIOLOGY (Core-III)
COURSE OBJECTIVES:
At the end of the lecture, the student will be able to:
106
Define Epidemiology, disease Transmission.
Explain Measuring the occurrence of disease: Morbidity and Mortality, Assessing the Validity and
Reliability of diagnostic and screening tests.
Identify the roles of genetic and environmental factors in disease causation,
Evaluate health services by Epidemiology.
Lecture
No
Title of Lecture Durati
on
Teaching Method
1
Introduction
1 hour Lecture/ power
point
2 The dynamics of disease Transmission
“ “
3 The dynamics of disease Transmission
“ “
4 Measuring the occurrence of disease:
Morbidity and Mortality
“ “
5 Measuring the occurrence of disease:
Morbidity and Mortality
“ “
6 Measuring the occurrence of disease:
Morbidity and Mortality
7 Assessing the Validity and Reliability of
diagnostic and screening tests
“ “
8 Assessing the Validity and Reliability of diagnostic
and screening tests
“ “
9 Assessing the Validity and Reliability of diagnostic
and screening tests
“ “
10 Understanding biases and confounding “ “
11 Understanding biases and confounding “ “
12 Cohort Studies “ “
13 Cohort Studies “ “
14 Case-Control Studies and other study designs “ “
15 Comparing Cohort and Case-Control Studies “ “
107
16 Comparing Cohort and Case-Control Studies “ “
17 Indentifying the roles of genetic and
environmental factors in disease causation
“ “
18 Indentifying the roles of genetic and
environmental factors in disease causation
“ “
19 Using Epidemiology to evaluate health services “ “
20 Using Epidemiology to evaluate health services “ “
21 The epidemiologic approach to evaluating
screening programs
“ “
22 Epidemiology and public policy “ “
23 Epidemiology and public policy “ “
24 Measure of association I (Relative risk/odds ratio/
standardized mortality ratios/Attributable risk)
“ “
25 Measure of association I (Relative risk/odds ratio/
standardized mortality ratios/Attributable risk)
26 Ethical and professional issues in Epidemiology “ “
27 Ethical and professional issues in Epidemiology “ “
28 Investigation of disease outbreak “ “
29 Investigation of disease outbreak “ “
30 Causal inference “ “
31 Causal inference “ “
PCG-707 Pharmacognostic Instrumentation Techniques (Major I)
Course Objectives:
108
At the end of this course students will be able to:
This course is designed to make students be acquainted with the application of various instruments useful in research projects like UV Spectroscopy, IR Spectroscopy, NMR Spectroscopy and Mass Spectroscopy for structure elucidation , so that they can be able to resolve the peaks by using these technique and can identify the known and unknown compounds of natural products. In addition, they will learn other advanced chromatographic methods like GLC, HPLC, HPTLC, Chiral Chromatography, Ion Pair Chromatography and other analytical techniques like Capillary electrophoresis, thermo gravimetric analysis, calorimetry, Immuno-electrophoresis, Immune-precipitation, ELISA, Radio-Immunoassays etc. In addition, students will be well knowledgeable with the validation of equipments and processes of herbal product manufacturing.
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction, application and structure
elucidation using UV Spectroscopy
1 hour Lecture
2 Introduction, application and structure
elucidation using UV Spectroscopy
1 hour Lecture
3 Introduction, application and structure elucidation using IR Spectroscopy
1 hour Lecture
4 Introduction, application and structure elucidation using IR Spectroscopy
1 hour Lecture
5 Introduction, application and structure elucidation using NMR Spectroscopy
1 hour Lecture
6 Introduction, application and structure elucidation using NMR Spectroscopy
1 hour Lecture
109
7 Introduction, application and structure elucidation using Mass Spectroscopy
1 hour Lecture
8 Introduction, application and structure elucidation using Mass Spectroscopy
1 hour Lecture
9 Theory, Instrumentation, application of GLC
1 hour Lecture
10 Theory, Instrumentation, application of GLC
1 hour Lecture
11 Theory, Instrumentation, application of HPLC
1 hour Lecture
12 Theory, Instrumentation, application of
HPLC
1 hour Lecture
13 Theory, Instrumentation, application of
HPTLC
1 hour Lecture
17 Theory, Instrumentation, application of
HPTLC
1 hour lecture
18 Theory, Instrumentation, application of Chiral Chromatography
1 hour Lecture
19 Theory, Instrumentation, application of Chiral Chromatography
1 hour Lecture
20 Theory, Instrumentation, application of Ion Pair Chromatography
1 hour Lecture
21 Theory, Instrumentation, application of Ion Pair Chromatography
1 hour Lecture
22 Theory, Instrumentation, application of Capillary electrophoresis.
1 hour Lecture
110
23 Theory, Instrumentation, application of Capillary electrophoresis.
1 hour Lecture
24 Theory, instrumentation, and
application of thermo gravimetric
analysis
1 hour Lecture
25 Theory, instrumentation, and
application of thermo gravimetric
analysis
1 hour Lecture
26 Theory, instrumentation, and
application of differential thermal
analysis
1 hour Lecture
27 Theory, instrumentation, and application of differential thermal analysis
1 hour Lecture
28 Theory, instrumentation, and application of differential scanning and calorimetry
1 hour Lecture
29 Theory, instrumentation, and application of differential scanning and calorimetry
1 hour Lecture
30 Immuno-electrophoresis 1 hour Lecture
31 Immuno-electrophoresis 1 hour Lecture
32 Immune-precipitation 1 hour Lecture
33 ELISA 1 hour Lecture
34 Radio-Immunoassays 1 hour Lecture
35 Radio-Immunoassays 1 hour Lecture
36 Introduction, validation of equipments
and processes of herbal product
manufacturing etc.
1 hour Lecture
37 Introduction, validation of equipments
and processes of herbal product
1 hour lecture
111
manufacturing etc.
38 Introduction, validation of equipments
and processes of herbal product
manufacturing etc.
1 hour Lecture
39 Introduction, validation of equipments
and processes of herbal product
manufacturing etc.
1 hour Lecture
40 Introduction, validation of equipments
and processes of herbal product
manufacturing etc.
1 hour Lecture
References:
1. Herbal Drugs and Phytopharmaceuticals, a handbook for practice on scientific basis,by Max
Wichtl, Third Edition
2. Phytopharmaceutical Technology, Paul Heinz List, Peter C. Schmidt, CRC Press INC, 1989. 3. Phytochemicals & Phytopharmaceuticals by Fereidoon shahidi and Chi_Tang Ho. The
American Oil Chemists Society, 2000. 4. Pharmacognosy and Plant cultivation by Mohammad Ali, Vol 2, CBS Publishers and
Distributors, India.
5. Trease and Evans, Pharmacognosy, 16th edition, W.B. Saunders company, 2009.
6. Pharmaceutical analysis by P. Parimoo, CBS Publishers and distributors, First Edition 1998,
New Delhi.
7. Pharmaceutical analysis, Edited by Takera Higuchi, Hanffen hanssen, First edition 1997, CBS
Publishers and distributors, New Delhi.
PCG-709 Science and Clinical Practice of Herbal Medicine (Major- II)
112
Course Objectives:
At the end of this course students will be able to:
Appraise the science and clinical practice of herbal medicine. Justify the clinical application of herbal medicines for the treatment of different diseases. Interpret the case histories of different patients. Summarize current status of integration of herbal medicine in evidenced based medical therapy. Assess Quality control and Quality assurance in processing and manufacturing of herbal
medicine. Evaluate herb-herb, herb-drug and herb-food interactions.
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction to principles and Clinical
practice of Herbal medicine
1 hour lecture
2 Introduction to principles and Clinical
practice of Herbal medicine
1 hour lecture
3 Introduction to herbal clinical research 1 hour lecture
4 Introduction to herbal clinical research 1 hour lecture
5 Treatment approaches with Case histories and drug-disease profile of Digestive system diseases.
1 hour lecture
6 Treatment approaches with Case histories and drug-disease profile of Digestive system.
1 hour lecture
7 Treatment approaches with Case histories and drug-disease profile of Digestive system.
1 hour lecture
8 Treatment approaches with Case histories and drug-disease profile of Cardiovascular system.
1 hour lecture
9 Treatment approaches with Case histories and drug-disease profile of
1 hour lecture
113
Cardiovascular system.
10 Treatment approaches with Case histories and drug-disease profile of Respiratory system.
1 hour lecture
11 Treatment approaches with Case histories and drug-disease profile of Respiratory system.
1 hour lecture
12 Treatment approaches with Case histories and drug-disease profile of Nervous system.
1 hour lecture
13 Treatment approaches with Case histories and drug-disease profile of Nervous system.
1 hour lecture
17 Treatment approaches with Case histories and drug-disease profile of Renal system.
1 hour lecture
18 Treatment approaches with Case histories and drug-disease profile of Renal system.
1 hour lecture
19 Treatment approaches with Case histories and drug-disease profile of Reproductive system.
1 hour lecture
20 Treatment approaches with Case histories and drug-disease profile of Reproductive system.
1 hour lecture
21 Treatment approaches with Case histories and drug-disease profile of Reproductive system.
1 hour lecture
22 Treatment approaches with Case histories and drug-disease profile of Musculoskeletal system.
1 hour lecture
23 Treatment approaches with Case histories and drug-disease profile of Musculoskeletal system.
1 hour lecture
24 Treatment approaches with Case histories and drug-disease profile of Skin.
1 hour lecture
114
25 Treatment approaches with Case histories and drug-disease profile of Skin.
1 hour lecture
26 Treatment approaches with Case histories and drug-disease profile of Hepatic portal system.
1 hour lecture
27 Treatment approaches with Case histories and drug-disease profile of Hepatic portal system.
1 hour lecture
28 Treatment approaches with Case histories and drug-disease profile of Immune system.
1 hour lecture
29 Treatment approaches with Case histories and drug-disease profile of Immune system.
1 hour lecture
30 Treatment approaches with Case histories and drug-disease profile of Endocrine system.
1 hour lecture
31 Treatment approaches with Case histories and drug-disease profile of Endocrine system.
1 hour lecture
32 Current status and major issues of
integration of herbal medicine in
evidence based medical therapy
1 hour lecture
33 Factors affecting integration of herbal medicine into Modern medical practices.
1 hour lecture
34 Herb Quality issues 1 hour lecture
35 Quality control and Quality assurance in
processing and manufacturing of herbal
medicine.
1 hour lecture
36 Efficacy of herbal medicine 1 hour lecture
37 Herb safety issues 1 hour lecture
38 Herb-Herb Interactions 1 hour lecture
115
39 Herb-Drug Interactions 1 hour lecture
40 Herb-Food interactions 1 hour lecture
References:
1. Medical Herbalism, Science and practice of Herbal medicine by David Hoffman.
2. Awang D. V. Quality control and good manufacturing practices: Safety and efficacy of commercial herbs. Food Drug Law J. 1997; 52:341–4.
3. Awang D. V, Fugh-Berman A. Herbal interactions with cardiovascular drugs. J Cardiovasc Nurs.2002; 16(4):64–70.
4. Barrett B. Alternative, complementary, and conventional medicine: Is integration upon us? J Altern Complement Med. 2003; 9(3):417–27.
5. Blumenthal M. Guest editorial: The rise and fall of PC-SPES: New generation of herbal supplement, adulterated product, or new drug? Integr Cancer Ther. 2002; 1(3):266–70.
6. Boyd D. B. Integrative oncology: The last ten years-a personal retrospective. Altern Ther Health Med.2007;13(1):56–64.
7. Brinker F. Managing and interpreting the complexities of botanical research. Herbal Gram. 2009; 82:42–9.
8. Bruno J. J, Ellis J. J. Herbal use among U.S. elderly: 2002 National Health Interview Survey. Ann Pharmacother. 2005; 39(4):643–8.
9. Chadwick L, Fong H. H. S. Herb quality assurance and standardization in herb-drug interaction evaluation and documentation. In: Lam Y. W. F, Huang S. M, Hall S. D, editors. Herbal Supplement-Drug Interactions. New York: Taylor & Francis; 2006. pp. 191–203.
SEMESTER II
(PCG-702) Natural Products Drug Discovery (Major III):
Course Objectives:
116
At the end of this Course students will be able to:
Recognize natural molecule used in modern medicine practice. Evaluate Challenges in drug discovery from natural products. Predict the factors that may lead to the failure of a new drug. Recognize the physiological targets for drug discovery. Understand the biochemical and molecular basis of drug action. Explain the Computational data mining, rational drug design and structure activity
relationships. Describe preclinical evaluation of drug absorption, distribution, metabolism and excretion. Predict the factors leading to failure of new drug.
Lecture
No
Title of Lecture Duration Teaching Method
1
Introduction to Natural Product drug
discovery.
1 hour Lecture
2 Introduction to Natural Product drug
discovery
1 hour Lecture
3 Historical background 1 hour Lecture
4 Historical background 1 hour Lecture
5 Review of all natural molecule used in
modern medicine practice with
reference to current pharmacopeia
1 hour Lecture
6 Review of all natural molecule used in
modern medicine practice with
reference to current pharmacopeia
1 hour Lecture
7 Review of all natural molecule used in
modern medicine practice with
reference to current pharmacopeia
1 hour Lecture
117
8 Natural Products for drug discovery,
serendipitous discovery and the
changing perspectives in drug discovery.
1 hour Lecture
9 Natural Products for drug discovery,
serendipitous discovery and the
changing perspectives in drug discovery.
1 hour Lecture
10 Natural Products for drug discovery,
serendipitous discovery and the
changing perspectives in drug discovery.
1 hour Lecture
11 Challenges in drug discovery from
natural products.
1 hour Lecture
12 Role of traditional medicine knowledge
in the development of new
pharmaceutical agents.
1 hour Lecture
13 Role of traditional medicine knowledge
in the development of new
pharmaceutical agents.
1 hour Lecture
14 Predicting the factors that may lead to
the failure of a new drug candidate and
maximizing the chance of success.
1 hour Lecture
15 Predicting the factors that may lead to
the failure of a new drug candidate and
maximizing the chance of success.
1 hour Lecture
16 Animal studies in drug discovery. 1 hour Lecture
17 Case studies in drug discovery. 1 hour Lecture
18 Success stories and failures. 1 hour Lecture
19 Identification and validation of
physiological targets for drug discovery.
1 hour Lecture
20 Identification and validation of
physiological targets for drug discovery.
1 hour Lecture
21 Introduction to the biochemical and 1 hour Lecture
118
molecular basis of drug action.
22 Introduction to the biochemical and
molecular basis of drug action.
1 hour Lecture
23 Introduction to the biochemical and
molecular basis of drug action.
1 hour Lecture
24 Computational data mining 1 hour Lecture
25 Computational data mining 1 hour Lecture
26 Rational drug design and structure
activity relationships
1 hour Lecture
27 Rational drug design and structure
activity relationships
1 hour Lecture
28 Rational drug design and structure
activity relationships
1 hour Lecture
29 Compound selection for drug discovery 1 hour Lecture
30 Combinatorial chemistry 1 hour Lecture
31 Natural products and product extracts
as chemical starting points.
1 hour Lecture
32 Natural products and product extracts
as chemical starting points.
1 hour Lecture
33 Identifying chemical and Biochemical
Assays.
1 hour Lecture
34 Identifying chemical and Biochemical
Assays.
1 hour Lecture
35 Methods for the preclinical evaluation
of drug absorption, distribution,
metabolism and excretion
1 hour Lecture
119
36 Methods for the preclinical evaluation
of drug absorption, distribution,
metabolism and excretion
1 hour Lecture
37 Principles of toxicology 1 hour Lecture
38 Principles of toxicology 1 hour Lecture
39 Preclinical evaluation of drug safety 1 hour Lecture
40 Preclinical evaluation of drug safety 1 hour Lecture
References:
1. Natural product chemistry for Drug discovery by Antony D. Buss and Mark S. Butler by RSC publishing, Edition; 2010.
2. Natural Products: Drug Discovery and Therapeutic Medicine, Lixin Zhang, Arnold L. Demain, Springer, 2005
3. Natural Product Chemistry for Drug Discovery, Antony D. Buss and Mark S. Butler, Springer, 2009.
4. Natural Products as a Foundation for Drug Discovery John A. Beutler, Curr Protoc Pharmacol. 2009 September 1; 46: 9.11.1–9.11.21
5. Drug Discovery and Natural Products: End of an Era or an Endless Frontier by Jesse W.-H. Li and John C. Vederas.
6. The influence of natural products upon drugdiscovery by David J. Newman, Gordon M.
Cragg and Kenneth M. Snader, Nat. Prod. Rep., 2000,17, 215-234
PCG- 704 Cosmeceuticals and Nutraceuticals ((Major- IV)
Course Objectives:
At the end of this course students will be able to:
Summarize Herbs and herbal products for enhancing facial skin appearance, skin care. Justify Herbs and herbal products for hair growth and care. Assess an evidence-based approach to specific cosmeceutical ingredients.
120
Evaluate the safety of a cosmeceutical formulation. Evaluation of cosmeceutical product performance: design, implement and interpret
results of tests used to evaluate cosmeceuticals performance. Identification and characterization of bioactive components in food. Appraise comparative studies on the effectiveness of functional foods, nutraceuticals
and pharmaceuticals. Summarize neutraceutical products development. Interpret toxicological aspects of nutraceuticals or functional foods.
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction to Herbs and Herbal
Products as Cosmetics
1 hour lecture
2 Herbs and herbal products for
enhancing facial skin appearance, skin
care
1 hour lecture
3 Herbs and herbal products for
enhancing facial skin appearance, skin
care
1 hour lecture
4 Herbs and herbal products for hair
growth and care
1 hour lecture
5 Herbs and herbal products for hair
growth and care
1 hour lecture
6 Miscellaneous cosmetics including
perfumes
1 hour lecture
7 Over-the-counter herbal cosmeceuticals
formulations used in dermatology
1 hour lecture
8 An evidence-based approach to specific cosmeceutical ingredients.
1 hour lecture
An evidence-based approach to specific cosmeceutical ingredients.
1 hour lecture
9 Evaluate the safety of a cosmeceutical
formulation
1 hour lecture
121
10 Regulations governing the safety of
herbal cosmeceuticals products
1 hour lecture
11 Irritant and allergen reactions
experienced by consumers due to use of
certain cosmeceuticals
1 hour lecture
12 Evaluation of safety and allergenic
profile of cosmeceutical products
1 hour lecture
13 Functions of ingredients in
cosmeceutical products
1 hour lecture
14 Evaluate the origins and functions of the
many and varied ingredients used in
cosmeceuticals
1 hour lecture
15 Evaluations of cosmeceutical product
performance: design, implement and
interpret results of tests used to
evaluate cosmeceuticals performance
1 hour lecture
16 Evaluations of cosmeceutical product
performance: design, implement and
interpret results of tests used to
evaluate cosmeceuticals performance
1 hour lecture
17 Evaluations of cosmeceutical product
performance: design, implement and
interpret results of tests used to
evaluate cosmeceuticals performance
1 hour lecture
18 Introduction to Nutraceuticals,
Antioxidants, Prebiotics, Probiotics,
Omega 3 fatty acids and dietary fibres
1 hour lecture
19 Identification and characterization of
bioactive components in food
1 hour lecture
20 Identification and characterization of
bioactive components in food
1 hour lecture
21 Scientific studies that demonstrate the
effectiveness of bioactives on
1 hour lecture
122
biomarkers or physiological functions
22 Epidemiological studies that indicate
that diets enriched in bioactive
components can prevent diseases
1 hour lecture
23 Epidemiological studies that indicate
that diets enriched in bioactive
components can prevent diseases
1 hour lecture
24 Comparative studies on the
effectiveness of functional foods,
nutraceuticals and pharmaceuticals on
lowering blood cholesterol levels,
treating obesity, Alzheimer’s disease
and other diseases
1 hour lecture
25 Comparative studies on the
effectiveness of functional foods,
nutraceuticals and pharmaceuticals on
lowering blood cholesterol levels,
treating obesity, Alzheimer’s disease
and other diseases
1 hour lecture
26 Prophylactic versus reactive treatment
of disease with functional foods,
nutraceuticals and drugs
1 hour lecture
27 Delivery of functional ingredients in
enriched foods – issues of formulation
1 hour lecture
28 Neutraceutical product development 1 hour lecture
29 Neutraceutical product development 1 hour lecture
30 Encapsulation or slow release of
protected components
1 hour lecture
31 Consumer acceptance and perceptions
of functional foods
1 hour lecture
32 History of functional foods and the
potential for the future.
1 hour lecture
33 History of functional foods and the
potential for the future.
1 hour lecture
123
34 Food and drug interactions in treatment
of disease
1 hour lecture
35 Food and drug interactions in treatment
of disease - mechanisms of action
1 hour lecture
36 Food and drug interactions in treatment
of disease - mechanisms of action
1 hour lecture
37 Food and drug interactions in treatment
of disease - mechanisms of action
1 hour lecture
38 Components of specific foods that
interact with medications
1 hour lecture
39 Components of specific foods that
interact with medications
1 hour lecture
40 Toxicological aspects of nutraceuticals
or functional foods.
1 hour lecture
References:
1. Natural healing with herbs by Humbart Santill, Crest publishing house 2005.
2. Handbook of Dermatological drug therapy by udhay khopkar, Elsevier publishing ltd.
2007.
3. Handbook of synthetic and herbal cosmetics by Ankar kumar , published by sudhir gupta
Delhi.
4. Cosmetics processes and formulations handbook with herbal cosmetic technology and
formula, published by Sudhir gupta Delhi.
5. Pharmacognosy and Phytochemistry by M.Ali, CBS publisher 2008.
6. Cosmetics additives, an Industrial guide by Ernest W. Flick, Crest publishing house, 2005.
7. Clinically useful herbal drugs by Prof S.S. Agarwal, edition 2005, Ahuja publishing house.
8. Handbook of Nutraceuticals and functional foods by Robert E.C. Wildman, Taylor and
Francis 2006.
9. Nutraceuiticals, a guide for health care professionals by Brian Lockwood, second edition,
Published by Pharmaceutical press.
10. Pharmacognosy by C. K. Kokate, Nirali Parakshan, 2009.
124
PCG 706 Natural Toxicology (Major V)
Course Objectives:
At the end of this course students will be able to:
Understand the Historical background, Scope and relationship of toxicology to other sciences. Natural Toxins introduction and types of Natural toxins Explain Endogenous toxins of plant origin. Analyze Natural contaminants. Summarize Microbial toxins. Interpret Mycotoxins and Animal toxins. Explain in detail about Marine Toxins.
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction to Toxicology 1 hour Lecture
2 Historical background 1 hour Lecture
3 Scope and relationship to other sciences 1 hour Lecture
4 Introduction to Natural Toxins 1 hour Lecture
5 Types of Natural Toxins 1 hour Lecture
6 Toxic Phenolic substances (Flavonoids,
Tannins, Coumarin, safrole, and
myristicin)
1 hour Lecture
125
7 Toxic Phenolic substances (Flavonoids,
Tannins, Coumarin, safrole, and
myristicin)
1 hour Lecture
8 Cyanogenic glycosides 1 hour Lecture
9 Cyanogenic glycosides 1 hour Lecture
10 Glucosinolates 1 hour Lecture
11 Acetylcholinesterase inhibitors 1 hour Lecture
12 Biogenic amines 1 hour Lecture
13 Central stimulants 1 hour Lecture
14 Natural contaminants; Mixing of edible
plants with toxic plants
1 hour Lecture
15 Natural contaminants; Mixing of edible
plants with toxic plants
1 hour Lecture
16 Contamination resulting from intake of
toxic substances by animals
1 hour Lecture
17 Contamination of milk with plant toxins 1 hour Lecture
18 Natural toxins in aquatic organisms 1 hour Lecture
19 Microbial toxins; Introduction 1 hour Lecture
20 Food-borne diseases 1 hour Lecture
21 Bacterial toxins (Membrane-affecting
bacterial toxins)
1 hour Lecture
22 Sub-unit bacterial toxins, Lesion-causing
bacterial toxins
1 hour Lecture
23 Immuno-active bacterial endotoxins 1 hour Lecture
24 Toxic microbial metabolites; Biogenic
amines, Ethyl carbamate
1 hour Lecture
25 Mycotoxins; General, Aflatoxins 1 hour Lecture
26 Deoxynivalenol, Ergot alkaloids 1 hour Lecture
126
27 Patulin, Sterigmatocystin 1 hour Lecture
28 Zearalenone, Ochratoxin A 1 hour Lecture
29 Animal Toxins; Cardioactives 1 hour Lecture
30 Hemotoxins, Myotoxins 1 hour Lecture
31 Neurotoxins 1 hour Lecture
32 Vasoactives etc 1 hour Lecture
33 Marine Toxins: Scombrotoxic fish
poisoning
1 hour Lecture
34 Ciguatera poisoning 1 hour Lecture
35 Paralytic shellfish poisoning, Neurotoxic
shellfish poisoning
1 hour Lecture
36 Amnesic shellfish poisoning etc.
1 hour Lecture
37 Mineral Toxins: Aluminium 1 hour Lecture
38 Mineral Toxins:Arsenic 1 hour Lecture
39 Mineral Toxins:Lead 1 hour Lecture
40 Mineral Toxins:Arsenic 1 hour Lecture
References:
1. Culliney TW, D. Pementel, Pesticides and natural toxins in food, Agri. Ecosys. Environ. 41, 297-320, 1992
2. Davidek J, Natural toxic compounds of Food, CRC Press, Inc, 1995 3. Doyle MP, Foodborne bacterial pathogen New York, Marcel dekker, Inc, 1989 4. Hu.Y.H, JR Gorham, Foodborne disease handbook vol 1, Disease caused by bacteria, New
York, Marcel dekker, Inc. 1994 5. Keeler R.F, A.T. Tu, Plant and Fungal toxins, Vol 1, Handbook of natural toxins, New York,
Marcel dekker. Inc. 1983. 6. Sarhma R.P. Mycotoxins and Phytoalezins, CRC Press, 1991 7. Medical Toxicology of Natural Substances: Foods, Fungi, Medicinal Herbs, Plants, and
Venomous Animals by Donald G. Barceloux, John Wiley & Sons, 2008.
127
8. Tu A.T. Marine toxins and venoms, Vol 3, Handbook of natural toxins, New York, Marcel dekker, Inc. 1998.
9. Encyclopedia of Aquatic Ecotoxicology, Blaise, Christian; Férard, Jean-François (Eds.) 2013.
10. Environmental Pollution, S. V. S. Rana, Alpha Science International Ltd., 2006.
PCG 708 Biosynthesis of Natural Products (Major -VI)
Course Objectives:
At the end of this course students will be able to:
Explain biosynthesis of natural products. Summarize biosynthesis of natural products. Relate biosynthesis of natural products
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction of biosynthesis of natural
products
1 hour lecture
2 Primary and Secondary Metabolism 1 hour lecture
3 Primary and Secondary Metabolism 1 hour lecture
4 The Building blocks and construction
mechanisms
1 hour lecture
5 Acetate Pathway 1 hour lecture
6 Acetate Pathway 1 hour lecture
7 Shikimate Pathway 1 hour lecture
8 Shikimate Pathway 1 hour lecture
128
9 Mevalonate pathway 1 hour lecture
10 Mevalonate pathway 1 hour lecture
11 Mechanism and biosynthesis of
peptides, proteins and other amino acid
derivatives
1 hour lecture
12 Mechanism and biosynthesis of
peptides, proteins and other amino acid
derivatives
1 hour lecture
13 Mechanism and biosynthesis of
peptides, proteins and other amino acid
derivatives
1 hour Lecture
14 Mechanism and biosynthesis of
peptides, proteins and other amino acid
derivatives
1 hour Lecture
15 mechanism and biosynthesis of
peptides, proteins and other amino acid
derivatives
1 hour Lecture
16 Mechanism and biosynthesis of
carotenoids, vitamin A
1 hour Lecture
17 Mechanism and biosynthesis of
carotenoids, vitamin A
1 hour Lecture
18 Mechanism and biosynthesis of
carotenoids, vitamin A
1 hour Lecture
19 Mechanism and biosynthesis of Water
soluble vitamins
1 hour Lecture
20 Mechanism and biosynthesis of Water
soluble vitamins
1 hour Lecture
21 Mechanism and biosynthesis of Water
soluble vitamins
1 hour Lecture
22 Mechanism and biosynthesis of Water
soluble vitamins
1 hour Lecture
129
23 Mechanism and biosynthesis of Water
soluble vitamins
1 hour Lecture
24 Mechanism and biosynthesis of
Phenolic plant products
1 hour Lecture
25 Mechanism and biosynthesis of
Phenolic plant products
1 hour Lecture
26 Mechanism and biosynthesis of
Phenolic plant products
1 hour lecture
27 Mechanism and biosynthesis of tannins
and lignans
1 hour lecture
28 Mechanism and biosynthesis of tannins
and lignans
1 hour lecture
29 Mechanism and biosynthesis of tannins
and lignans
1 hour lecture
30 Mechanism and biosynthesis of
Terpenes.
1 hour lecture
31 Mechanism and biosynthesis of
Terpenes.
1 hour lecture
32 Mechanism and biosynthesis of
Terpenes
1 hour lecture
33 Mechanism and biosynthesis of
glycosides
1 hour lecture
34 Mechanism and biosynthesis of
glycosides
1 hour lecture
35 Mechanism and biosynthesis of
glycosides
1 hour lecture
36 Mechanism and biosynthesis of
glycosides
1 hour lecture
37 Mechanism and biosynthesis of
alkaloids
1 hour lecture
38 Mechanism and biosynthesis of 1 hour lecture
130
alkaloids
39 Mechanism and biosynthesis of
alkaloids
1 hour lecture
40 Mechanism and biosynthesis of
alkaloids
1 hour lecture
References:
1. Medicinal natural products, a biosynthetic approach, Paul M. devick, John Wiley and Sons. 2002.
2. Total synthesis of natural products by John AP, Simson, John Wiley and Sons, Vol. 7, 1988.
3. Natural Products: The secondary metabolites by James R Hanson, RSC Publishing, 2003.
4. Studies in natural products chemistry, edited by Atta-ur-Rehman, Elsevier, 2013.
5. Natural Products: A Laboratory Guide By Raphael Ikan, Academic press, 1991.
PCG 710 Regulatory Affairs of Herbal Medicines (Major -VII)
Course Objectives:
At the end of this lecture students will be able to:
Explain ethical principles relating to treatment decisions.
Summarize Traditional herbal medicine and human health.
Demonstrate rules and Regulation for registration of Herbal medicines.
Outline WHO and FDA policies and Activities.
Describe Ethics related to epidemiology, pharmacology and utilization of herbal medicines.
131
Recognize Policies/laws on traditional medicine/complementary/alternative medicine and
Principles/policies relating to the Conduct of Medical herbalists.
Explain Current regulatory situation of herbal medicines in various countries.
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction, ethical principles relating
to treatment decisions.
1 hour Lecture
2 Introduction, ethical principles relating
to treatment decisions.
1 hour Lecture
3 Introduction, ethical principles relating
to treatment decisions.
1 hour Lecture
4 Introduction, ethical principles relating
to treatment decisions.
1 hour Lecture
5 Traditional herbal medicine and human
health.
1 hour Lecture
6 Traditional herbal medicine and human
health.
1 hour Lecture
7 Regulation and registration of Herbal
medicines.
1 hour Lecture
8 Regulation and registration of Herbal
medicines.
1 hour Lecture
9 Regulation and registration of Herbal
medicines.
1 hour Lecture
10 Regulation and registration of Herbal
medicines.
1 hour Lecture
11 Regulation and registration of Herbal
medicines.
1 hour Lecture
12 Regulation and registration of Herbal
medicines.
1 hour Lecture
132
13 WHO and FDA policies and Activities. 1 hour Lecture
14 WHO and FDA policies and Activities. 1 hour Lecture
15 WHO and FDA policies and Activities. 1 hour Lecture
16 WHO and FDA policies and Activities. 1 hour Lecture
17 WHO and FDA policies and Activities. 1 hour Lecture
18 WHO and FDA policies and Activities. 1 hour Lecture
19 Ethics related to epidemiology,
pharmacology and utilization of herbal
medicines.
1 hour Lecture
20 Ethics related to epidemiology,
pharmacology and utilization of herbal
medicines.
1 hour Lecture
21 Ethics related to epidemiology,
pharmacology and utilization of herbal
medicines.
1 hour Lecture
22 Ethics related to epidemiology,
pharmacology and utilization of herbal
medicines.
1 hour Lecture
23 Ethics related to epidemiology,
pharmacology and utilization of herbal
medicines.
1 hour Lecture
24 Ethics related to epidemiology,
pharmacology and utilization of herbal
medicines.
1 hour Lecture
25 Policies/laws on traditional medicine
and complementary/alternative
medicine.
1 hour Lecture
26 Policies/laws on traditional medicine
and complementary/alternative
medicine.
1 hour Lecture
27 Policies/laws on traditional medicine
and complementary/alternative
1 hour Lecture
133
medicine.
28 Policies/laws on traditional medicine
and complementary/alternative
medicine.
1 hour Lecture
29 Policies/laws on traditional medicine
and complementary/alternative
medicine.
1 hour Lecture
30 Policies/laws on traditional medicine
and complementary/alternative
medicine.
1 hour Lecture
31 Policies/laws on traditional medicine
and complementary/alternative
medicine.
1 hour Lecture
32 Principles/policies relating to the
Conduct of Medical herbalists.
1 hour Lecture
33 Principles/policies relating to the
Conduct of Medical herbalists.
1 hour Lecture
34 Principles/policies relating to the
Conduct of Medical herbalists.
1 hour Lecture
35 Principles/policies relating to the
Conduct of Medical herbalists.
1 hour Lecture
36 Principles/policies relating to the
Conduct of Medical herbalists.
1 hour Lecture
37 Current regulatory situation of herbal
medicines in various countries.
1 hour Lecture
38 Current regulatory situation of herbal
medicines in various countries.
1 hour Lecture
39 Current regulatory situation of herbal
medicines in various countries.
1 hour Lecture
40 Current regulatory situation of herbal
medicines in various countries.
1 hour Lecture
134
References:
1. Regulations: Herbal medicine rule book by Natasha Gilbert 21 December 2011
2. FDA Regulatory Affairs: A Guide for Prescription Drugs, Medical Devices, and
Biologics Douglas J. Pisano (Editor), David Mantus, CRC Press, 2003.
3. Fundamentals of US regulatory by regulatory affairs professional society, seventh edition, 2011
4. Medical product regulatory affairs, Pharmaceuticals, diagnostic, medical devices by John J.
Tobin, Published by Willey, 2008.
5. Development of FDA regulated medical products, prescription drugs, biologics and medical
devices by Elaine whitmore, 2nd Edition 2003.
6. Natural healing with herbs by Humbart Santill, Crest publishing house 2005.
7. Therapeutic guide to herbal medicine by American botanical council, 1998.
PCG 712 Structure Elucidation of Natural products (Major VIII)
Course Objectives:
At the end of this lecture students will be able to:
Understand elucidation methods of natural molecules.
Describe in detail about methods of isolation and characterization of biologically active natural
products from the recent literature.
Explain the identification and biosynthesis of bioactive molecules from the natural products.
Determine Application of spectroscopic and chemical techniques to elucidate the structure of
natural products with particular reference to Alkaloids, Steroids, Saponins, Flavonoids and
Terpenes.
135
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction to elucidation methods of
natural molecules.
1 hour Lecture
2 Introduction to elucidation methods of
natural molecules.
1 hour Lecture
3 Introduction to elucidation methods of
natural molecules.
1 hour Lecture
4 Introduction to elucidation methods of
natural molecules.
1 hour Lecture
5 Introduction to elucidation methods of
natural molecules.
1 hour Lecture
6 Introduction to elucidation methods of
natural molecules.
1 hour Lecture
7 Introduction to elucidation methods of
natural molecules.
1 hour Lecture
8 Introduction to elucidation methods of
natural molecules.
1 hour Lecture
9 Introduction to elucidation methods of
natural molecules.
1 hour Lecture
10 Introduction to elucidation methods of
natural molecules.
1 hour Lecture
11 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
12 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
136
13 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
14 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
15 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
16 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
17 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
18 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
19 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
20 Study methods of isolation,
characterization, identification, and
1 hour Lecture
137
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
21 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
22 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
23 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
24 Study methods of isolation,
characterization, identification, and
biosynthesis of biologically active or
potentially active natural products from
the recent literature.
1 hour Lecture
25 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
26 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
27 Application of spectroscopic and
chemical techniques to elucidate the
1 hour Lecture
138
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
28 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
29 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
30 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
31 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
32 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
33 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
1 hour Lecture
139
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
34 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
35 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
36 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
37 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
38 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
39 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
1 hour Lecture
140
Steroids, Saponins, Flavonoids and
Terpenes.
40 Application of spectroscopic and
chemical techniques to elucidate the
structure of natural products with
particular reference to Alkaloids,
Steroids, Saponins, Flavonoids and
Terpenes.
1 hour Lecture
References:
1. Structure elucidation of natural products by mass spectrometry, Volume II: Steroids,
Terpenoids, Sugars, and Miscellaneous Classes, Herbert & Carl Djerassi, Dudley H.
Williams Budzikiewicz.
2. Principles of Instrumental analysis, Douglas A, skoog, 5th edition, Saunders college publishing,
Philadelphia 1998.
3. Mass-spectrophotometry-Instrumentation, Interpretation and applications, Roy ekman, Jerzy
silberring, New Jersy 2009.
4. Structure Elucidation by NMR in Organic Chemistry: A Practical Guide, Third revised edition, 2003.
SEMESTER 3
PCG 711 Nutritional Herbology (Major- IX)
Course Objectives:
At the end of this Course students will be able to:
141
Understand Nutritional herbology and its significance. Describe history of herbs usage as foods and medicine. Analyze regional and cultural influences on the evolution of herbology. Classify herbs and nutritional constituents. Construct Nutritional profile for commonly used herbs and natural foods. Investigate most popular herbal combinations and formulas, Effects on body systems, Patents
and laws pertaining to herbs and natural healing. Describe Methods of Analysis and biological significance of nutrients in food products and herbs.
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction to nutritional herbology 1 hour Lecture
2 Introduction to nutritional herbology 1 hour Lecture
3 Significance and scope of Nutrition
herbology
1 hour Lecture
4 History of usage of herbs as foods and
medicine
1 hour Lecture
5 History of usage of herbs as foods and
medicine
1 hour Lecture
6 Regional and cultural influences on the
evolution of herbology.
1 hour Lecture
7 Regional and cultural influences on the
evolution of herbology.
1 hour Lecture
8 Regional and cultural influences on the
evolution of herbology.
1 hour Lecture
9 Classification of herbs and nutritional
constituents
1 hour Lecture
10 Classification of herbs and nutritional
constituents
1 hour Lecture
142
11 Classification of herbs and nutritional
constituents
1 hour Lecture
12 Classification of herbs and nutritional
constituents
1 hour Lecture
13 Classification of herbs and nutritional
constituents
1 hour Lecture
14 Classification of herbs and nutritional
constituents
1 hour Lecture
15 Classification of herbs and nutritional
constituents
1 hour Lecture
16 Classification of herbs and nutritional
constituents
1 hour Lecture
17 Classification of herbs and nutritional
constituents
1 hour Lecture
18 Nutritional profile for commonly used
herbs and natural foods.
1 hour Lecture
19 Nutritional profile for commonly used
herbs and natural foods.
1 hour Lecture
20 Nutritional profile for commonly used
herbs and natural foods.
1 hour Lecture
21 Nutritional profile for commonly used
herbs and natural foods.
1 hour Lecture
22 Nutritional profile for commonly used
herbs and natural foods.
1 hour Lecture
23 Nutritional profile for commonly used
herbs and natural foods.
1 hour Lecture
143
24 Nutritional profile for commonly used
herbs and natural foods.
1 hour Lecture
25 Nutritional profile for commonly used
herbs and natural foods.
1 hour Lecture
26 Nutritional profile for commonly used
herbs and natural foods.
1 hour Lecture
27 Most popular herbal combinations and
formulas
1 hour Lecture
28 Most popular herbal combinations and
formulas
1 hour Lecture
29 Most popular herbal combinations and
formulas
1 hour Lecture
30 Effects on body systems 1 hour Lecture
31 Effects on body systems 1 hour Lecture
32 Patents and laws pertaining to herbs
and natural healing
1 hour Lecture
33 Patents and laws pertaining to herbs
and natural healing
1 hour Lecture
34 Methods of Analysis and biological
significance of nutrients in food
products and herbs.
1 hour Lecture
35 Methods of Analysis and biological
significance of nutrients in food
products and herbs.
1 hour Lecture
144
36 Methods of Analysis and biological
significance of nutrients in food
products and herbs.
1 hour Lecture
37 Methods of Analysis and biological
significance of nutrients in food
products and herbs.
1 hour Lecture
38 Methods of Analysis and biological
significance of nutrients in food
products and herbs.
1 hour Lecture
39 Methods of Analysis and biological
significance of nutrients in food
products and herbs.
1 hour Lecture
40 Methods of Analysis and biological
significance of nutrients in food
products and herbs.
1 hour Lecture
References:
1. Nutritional Herbology: A Reference Guide to Herbs by Mark Pedersen, Morningstar
Publications, 1994.
2. The Green Pharmacy Herbal Handbook: Your Everyday Reference to the Best Herbs for
Healing by James A. Duke, Rodale Press, Emmaus, Pennsylvania, 1997.
3. Pharmacognosy by Varro-e-Tyler, 10th edition, 2009.
4. Trease and Evans Pharmacognosy, 16th Edition, W.B. Saunders Company. 2009
5. The Natural pharmacy by Skye Lininger D.C., Jonathan Wright, Prima Health, 1998.
6. Reader’s Digest natures medicines, A guide to herbal medicine published by Reader’s digest.
7. Natural healing with herbs by Humbart Santill, Crest publishing house 2005.
PCG- 713 Agricultural Pharmacy (Major -X)
145
Course Objectives:
At the end of this course students will be able to:
To summarize plant evolution, taxonomy, morphology and distribution. Explain plants cultivation. Value Chemical and Pharmacological status, Drying, Storage, Processing, Economics
and Utilization of different species of plants in agriculture.
Lecture
No
Title of Lecture Duration Teaching Method
1 Plant Evolution 1 hour Lecture
2 Plant Taxonomy 1 hour Lecture
3 Plant Morphology 1 hour Lecture
4 Plant Morphology 1 hour Lecture
5 Plant Distribution 1 hour Lecture
6 Plant species 1 hour Lecture
7 Mode of propagation of plants 1 hour Lecture
8 Mode of propagation of plants 1 hour Lecture
9 Plant cultivation 1 hour Lecture
10 Plant cultivation 1 hour Lecture
11 Land preparation for small scale
cultivation
1 hour Lecture
12 Land preparation of large scale
cultivation
1 hour Lecture
13 Soil and climatic factors in plants
cultivation
1 hour Lecture
14 Soil and climatic factors in plants 1 hour Lecture
146
cultivation
15 Planting, Fertilizers, Irrigation 1 hour Lecture
16 Intercultures, Transplantation 1 hour Lecture
17 Intercultures, Transplantation 1 hour Lecture
18 Pests and Diseases 1 hour Lecture
19 Pests and Diseases 1 hour Lecture
20 Harvesting, Yielding 1 hour Lecture
21 Introduction to Chemical and
Pharmacological status, Drying, Storage,
Processing, Economics and Utilization of
Santalum album, Saussurea lappa
1 hour Lecture
22 Introduction to Chemical and
Pharmacological status, Drying, Storage,
Processing, Economics and Utilization of
Solanum species, Camellia sinensis
1 hour Lecture
23 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Ammi majus Linn.,
Anethum graveolans
1 hour Lecture
24 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Atropa belladonna,
Catharanthus roseus
1 hour Lecture
25 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Apium graveolans,
Cinchona spp.
1 hour Lecture
26 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Cinnamomum
zeylanicum, Coleus forskohlii
1 hour Lecture
27 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
1 hour Lecture
147
and Utilization of Coriandrum sativum,
Cumin spp.
28 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Foeniculum vulgare,
Trigonella foenum graecum
1 hour Lecture
29 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Datura spp., Digitalis
species
1 hour Lecture
30 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Artemisia spp.,
Dioscorea species
1 hour Lecture
31 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Duboisia species,
Eucalyptus globulus
1 hour Lecture
32 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Humulus lupulus,
Cephaelis Ipecacuanha
1 hour Lecture
33 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Cymbopogon citratus,
Matricaria chamomilla
1 hour Lecture
34 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Mentha spp.,
Pelargonium species
1 hour Lecture
35 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Piper spp., Elletaria
cardamomum
1 hour Lecture
36 Chemical and Pharmacological status, 1 hour Lecture
148
References:
1. Pharmacognosy and Plant cultivation by Mohammad Ali, Vol. 2, CBS Publishers and Distributors,
India.
2. Pharmacognosy by Varro-e-Tyler, 10th edition, 2009.
3. Trease and Evans Pharmacognosy, 16th Edition W.B. Saunders Company. 2009
4. Textbook of Pharmacognosy by Biren shah, First edition, Elsevier, 2010.
5. Pharmacognosy by C. K. Kokate, Nirali Parakshan, 2009.
6. Herbs cultivation and medicinal uses by H. Panda, National institute of industrial research, 2000.
List of Faculty (full time/Visiting)
List of Full Time Teaching Faculty at Faculty of Pharmaceutical Sciences
Drying, Storage, Processing, Economics
and Utilization of Eugenia caryophyllus,
Myristica fragrans
37 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Zingiber officinale,
Curcuma spp.
1 hour Lecture
38 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Papaver somniferum,
Plantago ovata
1 hour Lecture
39 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Pyrethrum spp.
1 hour Lecture
40 Chemical and Pharmacological status,
Drying, Storage, Processing, Economics
and Utilization of Rauwolfia serpentine
and Claviceps purpurea.
1 hour Lecture
149
Department of Pharmacognosy:
1. Ms. Farah Saeed , M.Phil. Ph.D 2. Ms. Umbreen Farrukh , M.Phil. Ph.D.(enrolled) 3. Ms. Tahseen Quds , M.Phil. Ph.D.(enrolled) 4. Dr. Kashif Shafique, MBBS , MPH , PhD
5. Prof.Dr. Usman Ghani. MSc, M.Phil, Phd (Visiting)
150
Department of Pharmacology: COURSE SCHEME-M.PHIL.
Semester Title of Course Course
Code
No. of Credit
Hrs.
Semester-1
.
Biostatistics (Core-I) PCL 701 3
Research methodology (Core-II) PCL 703 3
Principles of Epidemiology (Core-III) PCL 705 3
Pharmacological Research Techniques
(Major-I)
PCL 707
2
Molecular Biology and Contemporary
Medicine (Major-II)
PCL 709
3
14 Credit hrs.
Semester-II
Medical Genetics and Gene Therapy
(Major-III)
PCL 702
3
Autonomic Nervous System
& Gastrointestinal System (Major-IV)
PCL 704
2
Anti Microbials and Cancer
Chemotherapy (Major-V)
PCL 706 3
Toxicology and Autocoids, NSAIDs
(Major-VI)
PCL 708 3
Cardiovascular and Respiratory
Pharmacology (Major-VII)
PCL 710 2
Proteomics and Bioinformatics (Major-
VIII)
PCL 712
2
15 Credit hrs.
151
Semester Title of Course Course
Code
No. of Credit
Hrs.
Semester-3
.
Haemtopoietic System and
antihyperlipidemics (Major-IX)
PCL 711
2
Neuropharmacology and Endocrinology
(Major-X)
PCL 713
3
Journal Club
(Core-IV)
PCL 715
1
6 Credit hrs.
Semester-4
.
Research work and Submission of thesis
(Core-V)
PCL 714 6
7 Credit hrs.
Total Credit hours:
Semester-1 Semester-2 Semester-3 Semester-4 Total No. of
Credit Hrs.
14 15 6 6 41
Department of Pharmacology:
152
SEMESTER-1
PCL 701: BIOSTATISTICS: (CORE-I)
COURSE OBJECTIVE:
At the end of the lecture, the student will be able to: 1. Define Data Organization (Grouping Data), (Graphs and Charts). 2. Describe Symbols and Summation Notation Sample and Population 3. Explain Measures of Central Tendency, Measures of Dispersion, Probability, Discrete
Probability Distribution, Binomial, Poisson and Normal Distributions, Sampling Distribution, Hypothesis Testing, One Sample Test, Two Sample Test (Independent Population)
4. Two Sample Test (Paired And Proportion),Chi-Square Distribution
5. Analysis Of Variance One Way ANOVA, Two Way ANOVA
6. Regression, Multiple Regression And Correlation,Non Parametric Statistics
Lecture
No
Title of Lecture Durati
on
Teaching Method
1
Introduction of Data Organization (Grouping
Data): Introduction, Biostatistics, Two Kind of
Statistics, Variable Types,
1 hr Lecture/ power
point
2
Frequency Distribution,Cumulative Frequency
Distribution, Frequency Distribution of
Continuous,
“ “
3 Relative Frequency Distribution, Stem and Leaf
Table
“ “
4
Data Organization (Graphs and Charts): Graphic
Presentation, Graphic Presentation for
Categorical Data,
“ “
5 Graphic Presentation for Quantitative Data
(Measurement),
“ “
153
6 Frequency Polygon, Pictograms, Distortion the
truth with Pictures
“ “
7 Symbols and Summation Notation Sample and
Population: Symbols, Summation, Population and
Sample, Random Sampling
“ “
9 Simple Random Sampling, Stratified Random
Sampling,
“ “
10 Systematic Sampling, Cluster Sampling,
Parameter and Statistic
“ “
11 Measures of Central Tendency: Types of
Summary Measures, Measures of Central
Tendency,
“ “
12 The Mean (Arithmetic Mean), The weighted
Mean, The Median, The Mode,
“ “
13 Measures of Central Tendency for Grouped Data,
The Mean, Median and mode for the Grouped
Data
“ “
14 Measures of Dispersion: Introduction, The
Range, The Mean Deviation, The Variance,
“ “
15 Standard Deviation, The Coefficient of Variation,
Measures of Dispersion for Grouped Data
“ “
16 Probability : Introduction ,Some Definitions,
Classical Probability,
“ “
17 Relative Frequency Probability, Notation and
Graphical Presentation of Events
“ “
18 Discrete Probability Distribution: Discrete
Random Variable,
“ “
19 Probability Distribution of Discrete Random
Variable.
“ “
20 Binomial, Poisson and Normal Distributions:
Bernoulli Trials, Binomial Distribution,
“ “
154
21 Poisson Distribution, Normal Distribution,
Standard Normal Distribution
“ “
22 Sampling Distribution: Introduction, Population
of Samples Means,
“ “
23 Properties of populations of Sample Means,
Properties of Distribution of Sample Means,
Central Limit Theorem
“ “
24 Estimating Means (Large Sample): Estimating
Mean, Confidence Interval Estimate, Confidence
Interval for the Population Mean μ
“ “
25 Determination of Sample Size for Estimating
Means, Confidence Interval for Population Mean
(Small Samples), Confidence Interval for
Population Mean μ
“ “
26 Small Interval, σ Known, T Distribution,
Confidence Interval for μ, Small Sample, σ
Unknown,
“ “
27 Confidence Interval for Population Proportion
(Large Sample), The Sampling Distribution of a
proportion,
“ “
28 Determining the sample Size for Estimating
Proportion
“
29 Hypothesis Testing: Introduction, Some
Definition, Hypothesis Testing Procedure,
Hypothesis Testing for a Population Mean (Large
Samples)
“ “
30 One Sample Test
Two Sample Test (Independent Population)
“ “
31 Two Sample Test (Paired And Proportion)
Chi-Square Distribution
“ “
32 Analysis Of Variance One Way ANOVA, Two Way
ANOVA
“ “
155
33 Non Parametric Statistics Sign Test, Wilcoxon
Signed Rank Test, Mann Whitney Test
The Kruskal Wallis H Test
“ “
156
PCL 703: RESEARCH METHODOLOGY (CORE-II)
COURSE OBJECTIVES:
At the end of the lecture, the student will be able to:
1. Define Concept of Research, Foundation of Hypothesis, 2. Criteria of Good, Research Literature Review. 3. Explain Design of Experiment, 4. Selection and preparation of tools for data collection, Practicalities of data collection. 5. Demonstrate Presentation skills & Writing skills
Lecture
No
Title of Lecture Durati
on
Teaching Method
1
Concept of Research and its Approaches/
Scientific approaches/ Research Terminologies.
1 hour Lecture/ power
point
2 Foundation of Hypothesis / How to do Research
Project/ Research on human Specimens.
“ “
3 Criteria of Good Research / Research and Quality
Assurance.
“ “
4 Criteria of Good Research / Research and
Quality Assurance.
“ “
5 Literature Review I: Efficient Use of Computers
and Internet : Search engines, digital libraries, E-
databases, archives
“ “
6 Literature Review I: Efficient Use of Computers
and Internet : Search engines, digital libraries, E-
databases, archives
“ “
7 Literature Review II: Selection of research
problem; Research Journals, Professional
Societies, Conferences, Scientific meetings,
Workshops
“ “
8 Design of Experiment: Scientific Study/Research “ “
157
Design.
9 Design of Experiment: Scientific
Study/Research Design.
“ “
10 Variables and its types. “ “
11 Variables and its types “ “
12 Selection and preparation of tools for data
collection, Practicalities of data collection
“ “
13 Selection and preparation of tools for data
collection, Practicalities of data collection
“ “
14 Sampling & Techniques “ “
15 Sampling & Techniques “ “
16 Processing and data analysis (statistical
approaches).
“ “
17 Processing and data analysis (statistical
approaches).
“ “
18 Analysis and interpreting of findings “ “
19 Analysis and interpreting of findings
20 Research Misconduct: Fraudulent research,
Plagiarism, retraction and cleansing, legal
burden.
Research Ethics/Informed Consent:
Confidentiality, deception, de-hoaxing and
desensitization
“ “
21 Scientific Integrity: Precision, reporting,
credits, authorship, mentoring Critical.
“ “
22 Evaluation of Research: Accuracy, precision,
reproducibility (stability and objectivity),
reliability,
“ “
23 quality, originality, bias and distortion, non-
deliberate bias, sampling bias.
“ “
24 Communication of Science: Communication
& Presentation skills: Oral: Technical
Presentation, Keynote address, invited
lectures, popular lecture
“ “
26 Communication of Science: Communication
& Presentation skills: Oral: Technical
“ “
158
Presentation, Keynote address, invited
lectures, popular lecture
27 Writing skills: Language, diction, and
contemporary style, data presentation and
documentation/ Thesis writing /
“ “
28 Guidelines for synopsis/ thesis writing) How
to present articles in „journal Club‟.
“ “
29 Publication: Paper, audience and journal,
basic structure of research paper, full-length
paper, short communications & notes,
“ “
30 case report, review and case series analysis,
editorial, book review, letter to editor;
refereeing process Editor‟s role and impact
factor.
31 Research Organizations: International &
national: of USA, UK, Germany and Japan,
Pakistan (PSF/ HEC/PMRC); Writing
Research Proposal / Grant agencies.
“ “
32 Research Organizations: International &
national: of USA, UK, Germany and Japan,
Pakistan (PSF/ HEC/PMRC); Writing
Research Proposal / Grant agencies.
33 Research Organizations: International &
national: of USA, UK, Germany and Japan,
Pakistan (PSF/ HEC/PMRC); Writing
Research Proposal / Grant agencies.
“ “
34 Research Proposal: components, research
economics, budgeting relevance to
significance of research objectives
“ “
PCL 705: PRINCIPLES OF EPIDEMIOLOGY (Core-III)
COURSE OBJECTIVES:
At the end of the lecture, the student will be able to:
Define Epidemiology, disease Transmission.
Explain Measuring the occurrence of disease: Morbidity and Mortality, Assessing the Validity and
Reliability of diagnostic and screening tests.
Identify the roles of genetic and environmental factors in disease causation,
Evaluate health services by Epidemiology.
Lecture Title of Lecture Durati Teaching Method
159
No on
1
Introduction
1 hour Lecture/ power
point
2 The dynamics of disease Transmission
“ “
3 The dynamics of disease Transmission
“ “
4 Measuring the occurrence of disease:
Morbidity and Mortality
“ “
5 Measuring the occurrence of disease:
Morbidity and Mortality
“ “
6 Measuring the occurrence of disease:
Morbidity and Mortality
7 Assessing the Validity and Reliability of
diagnostic and screening tests
“ “
8 Assessing the Validity and Reliability of diagnostic
and screening tests
“ “
9 Assessing the Validity and Reliability of diagnostic
and screening tests
“ “
10 Understanding biases and confounding “ “
11 Understanding biases and confounding “ “
12 Cohort Studies “ “
13 Cohort Studies “ “
14 Case-Control Studies and other study designs “ “
15 Comparing Cohort and Case-Control Studies “ “
16 Comparing Cohort and Case-Control Studies “ “
17 Indentifying the roles of genetic and
environmental factors in disease causation
“ “
18 Indentifying the roles of genetic and
environmental factors in disease causation
“ “
160
19 Using Epidemiology to evaluate health services “ “
20 Using Epidemiology to evaluate health services “ “
21 The epidemiologic approach to evaluating
screening programs
“ “
22 Epidemiology and public policy “ “
23 Epidemiology and public policy “ “
24 Measure of association I (Relative risk/odds ratio/
standardized mortality ratios/Attributable risk)
“ “
25 Measure of association I (Relative risk/odds ratio/
standardized mortality ratios/Attributable risk)
26 Ethical and professional issues in Epidemiology “ “
27 Ethical and professional issues in Epidemiology “ “
28 Investigation of disease outbreak “ “
29 Investigation of disease outbreak “ “
30 Causal inference “ “
31 Causal inference “ “
PCL 707 Pharmacological Research Techniques (Major-I)
COURSE OBJECTIVES:
At the end of the lecture, the student will be able to:
Explain basic principles, instrumentation & application of Patch clamp, Southern
blotting ,Western blotting , Northern blotting , ELISA , PCR , Flourescent insito hybridization
161
(FISH ),Power lab., Flame photometry, Histopathological techniques, Autoanalyzer, U.V.
Visible spectrophotometer,Spectroscopy, Mass Spectrometry , chromatography.
Lecture
No
Title of Lecture Durati
on
Teaching Method
1
Southern blotting 1 hour Lecture/ power
point
2 Southern blotting “ “
3 Western blotting “ “
4 Western blotting “ “
5 Northern blotting “ “
6 Northern blotting “ “
7 ELISA “ “
8 ELISA “ “
9 PCR “ “
10 PCR “ “
11 PCR “ “
12 Flourescent insito hybridization (FISH “ “
13 Basic principle, applications in
chromatography, Recent trends in
chromatography
“ “
14 HPLC (High Performance Liquid
Chromatography)
“ “
15 HPLC (High Performance Liquid
Chromatography)
“ “
16 LCMS (Liquid Chromatography - Mass
Spectrometry)
“ “
17 LCMS (Liquid Chromatography - Mass
Spectrometry)
“ “
18 GC (Gas Chromatography) “ “
19 GC (Gas Chromatography) “ “
162
20 GCMS (Gas Chromatography- Mass
Spectrometry)
“ “
21 GCMS (Gas Chromatography- Mass
Spectrometry)
“ “
22 HPTLC “ “
23 HPTLC “ “
24 Ion exchange chromatography “ “
25 Ion exchange chromatography “ “
26 Ion pair chromatography “ “
27 Ion pair chromatography “ “
28 Size exclusion chromatography “ “
29 Size exclusion chromatography “ “
30 Affinity chromatography “ “
31 Affinity chromatography “ “
32
Mass Spectrometry “ “
33 Mass Spectrometry “ “
34 Patch clamp “ “
35 Power lab.: Single unit recording, multiple unit
recording,Tissue bath recording
“ “
36 Power lab.: Single unit recording, multiple unit
recording,Tissue bath recording
“ “
37 Flame photometry “ “
38 Histopathological techniques “ “
39 Histopathological techniques “ “
40 Autoanalyzer “ “
41 U.V. Visible spectrophotometer “ “
163
164
PCL 709: Molecular Biology: Principles and Practices (Major-II)
COURSE OBJECTIVES
At the end of the lecture, the student will be able to understand:
Basic principles of molecular biology and genetic Engineering, different molecular techniques and their
clinical and industrial applications
Course coordinator: Dr. M Nouman Mughal (PhD)
Lecture No Title of Lecture Duration
Teaching Method
Molecular Biology: Genes to Proteins
1.
Introduction to DNA and RNA structure 2hrs Lecture/ power
point
2. Central dogma: From genome to proteins …… Dr. Nouman
3. Chromatin architecture: A hurdle to gene expression 1hr “
4. Epigenetic programming and reprogramming during development ….. “
5. Chromatin regulation of virus infection …… “
6. Post-transcriptional modifications …… “
7. Post-translational modifications: Ubiquitin and Ubiquitin Like
Modifiers (UBLs)
…… “
8. Ubiquitin, Proteasomes, and the regulation of Intracellular
Protein degradation
…… “
9. Lysosomes: Fusion and Function
…… “
10. Structural Biochemistry/Protein Folding and Chaperones …… “
11. The Evolution of Cancer …… “
165
Genetic Engineering and Biotechnology
Basic concepts: Genetic engineering and biotechnology 2hr “
12. Basic Principles:
Molecular cloning, Cloning Vectors and their host
2hrs “
13. Molecular Techniques: PCR, Gene sequencing, WB, Northern Blot,
Southern blot, FISH, Karyotyping,Tissue culture, Flow & image
Cytometry
3hrs “
Applications of Genetic Engineering/Biotechnology
14. Molecular Diagnostics
1hr “
15. Genetically Engineered Virus-Vectored Vaccines ….. “
16. An overview of current delivery systems in cancer gene therapy ….. “
17. Recent advances in gene therapy for Thalassemia
….. “
18. Forensic Molecular Biology: Using DNA technology to track down
crime
…… “
19. The impact of molecular biology on drug discovery …… “
Biology of Stem Cells and the Molecular Basis of the Stem State
20. Introduction to Stem cell biology 1hr Dr. Mohsin Wahid
21. Mitochondrial Regulation in Pluripotent Stem Cells “
22. Signaling pathways during maintenance and differentiation of
embryonic stem cells
“ “
23. Axis of ageing: telomeres, p53 and mitochondria “ “
24. Expression of Human RNA Binding Proteins and their role in Human
Genetic Disease
“ “
25. Reprogramming of somatic cells using exogenetic gene expression “ “
166
SEMESTER-2
PCL 702: Medical Genetics and Personalized medicine (Major-III):
COURSE OBJECTIVES:
At the end of the lectures, the student will be able to:
Define role of genetics in Pharmacology. Explain Cellular and Molecular Basis of Inheritance, Polygenic
and Multifactorial Inheritance, Genetic Factors in Common Diseases, Gene Mutation, Single gene
disorders. Explain personalized medicine, Gene Therapy, Telomere, Stem Cells and regenerative
medicine, Genetics of cancer, Molecular approaches to diseases, Genetics of Neuromuscular and
Cardiovascular disorders, Biotechnology in Clinical Medicine
Course Coordinator: Dr Mohsin Wahid (M.B.B.S, M.Phil, Ph.D)
Lecture No Title of Lecture Duration Teaching Method
Teacher
Date 2015
1
Pharmacogenomics and its role in Medicine
1 hour Lecture/ power point
2 Human Genome Project and its impact on Genomic Medicine
“ “
3 Transmission Patterns of Single-Gene
Disorders
“ “
4 Gene Mutations and its implication in
human diseases
“ “
5 Biochemical and Molecular Basis of Single-Gene
(Mendelian) Disorders
“ “
26. Telomere biology and its implications in human diseases “ “
167
6 Complex Multigenic Disorders
“ “
7 Cytogenetic Disorders Involving Autosomes
“ “
8 Cytogenetic Disorders Involving Sex
Chromosomes
“ “
9 Single-Gene Disorders with Nonclassic
Inheritance
“ “
10 Polymorphic Markers and Molecular
Diagnosis
“ “
11 Immunogenetics
“ “
12 Molecular Analysis of Genomic Alterations
“ “
13 Biochemical Genetics-in born errors of metabolism
“ “
14 Viruses and Epigenetics
“ “
15 Cancer Genetics and epigenetics
“ “
16 Role of telomeres in stem cells and cancers “ “
17 Genome sequencing in cancer
18 Role of Non coding RNA’s in human diseases
“ “
19 Genetics of Hypertension
“ “
20 Genetics of Human cardiovascular diseases
“ “
21 Genetics of Human cardiovascular diseases
“ “
22 Genetics of Diabetes mellitus/ Autoimmunity
“ “
23 Genetics of inherited channelopathies and cardiomyopathies
“ “
24 Genetics of neuromuscular disorders and Gene therapy
“ “
25 Genetics of neuromuscular disorders and Gene therapy
“ “
26 “ “
168
Monogenic causes of elevated HDL cholesterol and implications for
development of new therapeutics
27 Environmental medicine; Environmental testing of environmental pathogens
“ “
28 Biotechnology in Clinical Medicine: r-DNA derived drugs, Antibodies, and vaccines.
29 Biotechnology in Clinical Medicine: r-DNA derived drugs, Antibodies, and vaccines.
28 Stem cells and regenerative medicine
“ “
29 Stem cells and regenerative medicine
“ “
30 Human induced pluripotent stem cells and neurodegenerative
diseases: prospects for novel therapies
“ “
31 Human induced pluripotent stem cells and neurodegenerative
diseases: prospects for novel therapies
“ “
32 Next Generation Sequencing and its Clinical Applications
“ “
33
Induced Pluripotent Stem Cells
(iPSCs) for Modeling Mitochondrial DNA Disorders
“ “
34
Personalized medicine: Future and perspectives
35 Student presentation
PCL 704: Autonomic Nervous System and Gastrointestinal (Major-IV):
COURSE OBJECTIVES:
At the end of the lecture, the student will be able to:
Describe the Gastrointestinal & ANS systems & drugs acting on GIT & ANS
169
Lecture
No
Title of Lecture Durati
on
Teaching Method
1
Autonomic Nervous System:
Drugs acting at Synaptic and neuroeffector
junctional sites. Neurohumoral transmission.
Receptors, classification, theories, functions.
1 hour Lecture/ power
point
2 Neurotransmitters, acetylcholine, dopamine,
adrenaline, noradrenaline, prejunctional and
junctional effects
“ “
3 Cholinergic transmission, acetylcholinesterases,
blocking agents,
“ “
4 Adrenergic transmission, synthesis, release and
metabolism, effects on various organs, blocking
agents
“ “
5 Noncatecholamine, agents acting at the
neuromuscular junction and autonomic ganglia.
“ “
6 Dopomine : Synthesis release, fibers and their
distribution, receptors present in various organs.
“ “
7 Gastrointestinal System:
Brief physiology of gastronintestinal tract,
pathphysiology of gastric disordes of the system
with special reference of ulcer,
“ “
8 Role of parasympathetic and sympathetic
nervous system. Role of histamine, gastrin,
pentagastrin etc. Role of dopamine and its
“ “
170
receptors.
9 Emesis, physiology and pharmacology, part
played by central and autonomic nervous
system,.
“ “
10 Mechanism of anti-emetic drug. “ “
11 Anti-ulcer drugs
“ “
12 Anti-diarrheal and Anti-constipation drugs “ “
PCL 706: Antimicrobials and Cancer Chemotherapy (Major-V):
COURSE OBJECTIVES:
Lecture
No
Title of Lecture Durati
on
Teaching Method
1 Establishing presence/ severity of
infection.
1 hour Lecture/ power
point
2 Culture sensitivity/ concomitant
disease states.
“ “
3 Antimicrobials/ choices based on
culture sensitivity/ severity.
“ “
4 Infections of different systems with
drug of choices.
“ “
171
5 Fungal infection/ mycoses/
aspergillosis/ histoplasmosis (anti
fungal agents with MOA and
choices in different infections.)
“ “
6 Parasitic infections/ malaria/
amebiasis/ giardiasis/ scabies.
(Drug treatment and choices).
“ “
7 Spirochete infections/ rickettesial
infections (treatment and choices
of agents.)
“ “
8 Antivirals.
“ “
9 Staging, complications of
malignancy
“ “
10 Cytotoxic, chemotherapeutic
agents with MOA
“ “
11 Factors influencing response
“ “
12 Protocol and regimens with
different areas of cancers
“ “
13 Schedule/ drug resistance
“ “
14 Combinations/ choice of agents
“ “
15 Adjuvant chemotherapy “ “
172
16 Signal transduction pathway
inhibitors
“ “
17 Biologic response modifiers
“ “
18 Gene therapy
“ “
19 Interferon/ interleukins
“ “
20 Anti-virals (anti retro virals/
resistances/ therapeutic drug
monitoring/ opportunistic
infections in HIV infected patients
“ “
21 Prevention/ treatment of infection
in neutropenic cancer patients
“ “
173
PCL 708: Toxicology and Autocoids And NSAIDS (Major-VI):
COURSE OBJECTIVES:
At the end of lecture, the student will be able to:
Describe Fundamentals and scope of toxicology, Genotoxicity
Carcinogenicity,Reproductive Toxicity,Immunotoxicology
Skin Toxicology,Respiratory Toxicology,Hepatotoxicity
Nephrotoxicity,Neurotoxicity,Behaviourial Toxicology
Environmental and Ecotoxicology,Toxic responses of the ocular and visual system,Toxic responses of the
heart and vascular system,Toxic effects of Metals
Explain Pharmacological effects, H1 and H2 receptors, Cromolyn sodium, 5-Hydroxytryptamine,
Polypeptides, Pharmacological properties, Functions of endogenous kalikrien and kinins,
pharmacological properties of prostaglandins, prostacycline, thromboxane A2 and leukotrienes, Drugs
acting as inhibitors, steroidal and non-steroidal anti-inflammatory drugs (NSAID), DMARDS.
Lecture
No
Title of Lecture Durati
on
Teaching Method
1
Fundamentals and scope of toxicology: (i)
definition and classification (ii) sub-divisions of
toxicology (clinical, occupational, environmental,
forensic and ecotoxicology), mechanism of action
of agents, pharmacokinetics of toxicans.
1 hour Lecture/ power
point
2 General aspects for the management of acute
poisoning (i) maintenance of vital functions, (ii)
assessment of the level of consciousness,
“ “
3 (iii) prevention of absorption of poisons (iv)
enhancement of elimination of poisons, (v)
antidote therapy, (vi) continuing care
“ “
4 Genotoxicity “ “
174
5 Genotoxicity
“ “
6 Carcinogenicity
“ “
7 Carcinogenicity
“ “
8 Reproductive Toxicity
“ “
9 Reproductive Toxicity
“ “
10 Immunotoxicology
“ “
11 Immunotoxicology
“ “
12 Skin Toxicology
“ “
13 Skin Toxicology “ “
14 Respiratory Toxicology
“ “
15 Respiratory Toxicology
“ “
16 Hepatotoxicity
“ “
175
17 Hepatotoxicity
“ “
18 Nephrotoxicity
“ “
19 Nephrotoxicity
“ “
20 Neurotoxicity
“ “
21 Neurotoxicity
“ “
22 Behaviourial Toxicology
23 Behaviourial Toxicology
“ “
24 Environmental and Ecotoxicology
“ “
25 Environmental and Ecotoxicology
“ “
3426 Toxic responses of the ocular and visual system
“ “
27 Toxic responses of the ocular and visual system
“ “
28 Toxic responses of the heart and vascular system
“ “
29 Toxic responses of the heart and vascular system “ “
176
30 Toxic effects of Metals:
Introduction,Dose effect relationships,
Host factor influencing the toxicity of
metals,Metal binding proteins,Complexation and
chelation therapy
“ “
31 Major toxic metals with multiple effects
Arsenic, Cadmium,Lead, mercury,Nickel
“ “
32 Essential metals with potential for toxicity
Copper,Iron,Zinc
Metals related to medical therapy
Aluminium, Lithium, Platinum
“ “
33 Toxic effects of Animal Venoms and
Poisons:Properties of animal toxins
“ “
34 Arthropods,Arachnida,Chilopoda (centipedes)
“ “
35 Toxic effects of Animal Venoms and Poisons:
Diplopoda (millipedes),Insect,Reptilies
Antivenom
“ “
36 Toxic effects of Pesticides:
Introduction, Insecticides,Herbicides
“ “
37 Fungicides, Fumigants,Rodenticides “ “
177
38
Histamine: Pharmacological effects, H1 and H2
receptors. Inhibition of histamine.
1 hour Lecture/ power
point
39 Histamine: Pharmacological effects, H1 and H2
receptors. Inhibition of histamine.
“ “
40 Endogenous histamine, histamine release. Clinical
uses, pentagastrin.
“ “
41 Endogenous histamine, histamine release. Clinical
uses, pentagastrin
“ “
42 Cromolyn sodium, H1 and H2 blocking agents,
pharmacological properties, therapeutics uses.
“ “
43 Cromolyn sodium, H1 and H2 blocking agents,
pharmacological properties, therapeutics uses.
“ “
44 5-Hydroxytryptamine (5HT): Sources,
pharmacological actions,
“ “
45 Endogenous-5HT, functions, 5HT antagonist
ketanserine methysergide, cyproheptadine etc.
“ “
46 Endogenous-5HT, functions, 5HT antagonist
ketanserine methysergide, cyproheptadine etc.
“ “
47
Polypeptides: Angiotensin, synthesis and
degradation, Pharmacological properties,
“ “
48 endogenous renin-angiotensin system and its
functions, clinical considerations,
“ “
49 Inhibitors of renin-angiotensin system and
converting enzymes, Captopril, pharmacological
effects, therapeutic uses,
“ “
50 Renin-inhibitors, Plasma Kinins (kallidin, brady
kinins)
“ “
178
51 Pharmacological properties, Functions of
endogenous kalikrien and kinins
“ “
52 Therapeutic uses of vasodilator peptides.
Vasoactive intestinal polypeptides (VIP).
“ “
53 NSAIDS:Chemistry and biosynthesis, catabolism, “ “
54 pharmacological properties of prostaglandins,
prostacycline, thromboxane A2 and leukotrienes.
“ “
55 Effects on different systems: cardiovascular
system, block, platelets, kidney, urine formation,
smooth muscles, endocrines, reproduction,
inflammatory and immune response.
“ “
56 Lipoxygenase pathway, effect of leukotrienes, “ “
57 Lipoxygenase pathway, effect of leukotrienes,
58 Therapeutic uses of NSAIDs.
“ “
59 Therapeutic uses of NSAIDs “ “
60 Drugs acting as inhibitors, steroidal and non-
steroidal anti-inflammatory drugs (NSAID).
“ “
61 Drugs acting as inhibitors, steroidal and non-
steroidal anti-inflammatory drugs (NSAID).
“ “
62 Drugs acting as inhibitors, steroidal and non-
steroidal anti-inflammatory drugs (NSAID).
“ “
63 Antirehumatic Drugs (DMARDS) “ “
64 Antirehumatic Drugs (DMARDS) “ “
65 Antirehumatic Drugs (DMARDS) “ “
179
66 Drug used in Gout
“ “
67 Drug used in Gout
“ “
68 Other Analgesics
“ “
69 Other Analgesics
“ “
180
PCL 710: Cardiovascular And Respiratory System (Major-VII):
COURSE OBJECTIVES:
At the end of the lecture, the student will be able to:
Describe Hypertension, Angina, Asthma, COPD, Allergic rhinitis, Cough & its treatment.
Lecture
No
Title of Lecture Durati
on
Teaching Method
1
Hypertension Hypertension and regulation of
blood pressure: Definition, classification, etiology,
1 hour Lecture/ power
point
2 Normal regulation, postural baroreflex,
hypertensive emergencies, hypotension
“ “
3 Antihypertensive Drugs Classification of drugs,. “ “
4 Site of action of drugs in the body “ “
5 Mechanism, pharmacological effects, side effects,
adverse effects etc. of the drugs e.g. Diuretics,
sympatholytics, vasodilators, ACE inhibitors,
“ “
6 Past and present status of these antihypertensive
drugs.
“ “
7 Angina Pectoris Pathophysiology of angina.
Determination of myocardial oxygen demand.
“ “
8 Coronary blood flow and myocardial O2 supply.
Drugs e.g. coronary dilators, nitrates, calcium
blocking agents.
“ “
9 Non-Pharmacological Therapy Reduction of Body
weight. Reduction in Na+ in-take. Reduction in
“ “
181
alcohol use. Biofeed back therapy, K+ therapy,
physical exercise.
10 Etiology of arrhythmias, its types and
associated complications, Anti arrhythmic
drugs with side effects and adverse effects,
Treatment strategies in different types of
arrhythmias.
“ “
11 Choice of treatment with concurrent disease
states, titration of dose.
“ “
12 Diastolic heart failure, clinical presentation,
pharmacological therapy according to patient
profile, Different drugs with their adverse
effects and titration of doses in different
pathological conditions.
“ “
13 Treatment strategies in hypertrophic
cardiomyopathy, associated risk of Venous
Thromboembolism.
“ “
14 Etiology of stroke, risk factors,
Cerebrovascular diseases, Intracranial
hemorrhages with their treatment protocol
and adverse effects.
“ “
15 Treatment strategies of Cerebral ischemia
and risk evaluation with treatment strategies
and management of adverse effects.
“ “
16 Etiology of Hypertension neural, humoral
regulations, causes, general approach to
“ “
182
treatment, Different antihypertensives with
suggestive choice depending on clinical
history of patient, Hypertension in childhood,
in pregnancy, in concomitant disorders (
Asthma, COPD etc)
Ischemic heart diseases with grading,
coronary circulation and factors limiting
coronary perfusion, risk evaluation.
17 Role of platelet and thrombosis in I.H.D,
Antiplatelet and anticoagulant drugs with
rationalization of use in I.H.D, New platelet
disaggregaters and treatment strategies in
deep vein thromboses, in pulmonary
embolism etc and titration of doses of
anticoagulants with INR.
“ “
18 Drugs used in Asthma
“ “
19 Drugs used in Asthma
“ “
20 Drugs used to treat COPD
“ “
21 Drugs used to treat COPD
“ “
22 Allergic Rhinitis and Cough
“ “
23 Allergic Rhinitis and Cough
“ “
183
PCL 712 : PROTEOMICS & BIOINFORMATICS (Major-VIII)
COURSE OBJECTIVES:
At the end of the lecture, the student will be able to:
To develop skills of the students in the area of proteome analysis
To know more about proteins and their differential expression during normal and disease
states which poise main target for drug development
To know about the various tools of proteomics
To understand the various application of proteomics including Microarrays Explain,
Genome sequences, Genome sequence acquisition, Genomic variation, Genome
expression, applied research with DNA microarrays, & Proteomics
To have knowledge in the technique, methodology and Application of Proteomics tools
To have an overview of application of Microarrays in medicine
Lecture
No
Title of Lecture Durati
on
Teaching Method
1. Proteomics. Aims, strategies and
methods. Bioinformatics tools in
proteomics. Application of proteomics.
1 hr Lecture
2. Aims, strategies and challenges in
proteomics. Proteomics technologies:
2D-electrophoresis, MALDI-TOF mass
spectrometry, yeast 2-hybrid system.
“ “
3. Protein-protein interactions:
experimental and computational
methods, databases.
“ “
4. Introduction to Proteomics: The Proteome,
Genomics Vs Proteomics, Proteomics and the new
biology. Tools of Proteomics: Two dimensional
PAGE, Tandem Liquid chromatography, Types of
Mass spectrometers.
“ “
5. Analysis of proteomes: Two-dimensional
polyacrylamide gel electrophoresis: Sample
preparation, Solubilization, Reduction, Resolution
“ “
184
and Reproducibility of 2-DE, Detecting proteins in
polyacrylamide gels ( the names of stains is only
required), Image analysis of 2-DE gels
6. Mass spectrometry based methods for protein
identification: Correlative mass spectrometric
based identification strategies, De novo
sequencing using mass spectrometric data,
Separation methods for phosphorylation site
analysis, Peptide mass fingerprinting, Mining
proteomes, Bridging Genomics and
Proteomics
“ “
7. Introduction to Microarrays: Introduction to
Microarrays, Types of micorarrays .Cancer and
Genomic Microarrays: Improving diagnosis,
understanding complexity, Discover genome
dynamics in cancerous cells. Improving health care
with DNA Microarrays
“ “
8. Application of proteome analysis: Application of
proteome analysis: Drug development and
toxicology,, Phage antibodies as tools,
Glycobiology and Proteomics, In plant genetics
and breeding
“ “
SEMESTER 3
PCL 711: Haemtopoietic System, Antihyperlipidemics (Major-IX)
COURSE OBJECTIVES:
At the end of the lecture, the student will be able to:
Describe different types of anemia & treatment, Disorders of Coagulation, Basic pharmacology of anti-
caogulants, fibrinolytic, antithrombotic drugs, Polycythemia vera
185
Lecture
No
Title of Lecture Durati
on
Teaching Method
1
Haematopoiesis and haemostasis,. 1 hour Lecture/ power
point
2 Haematopoiesis and haemostasis “ “
3 Megalo-blastic anaemias “ “
4 Folic acid deficiency anemia “ “
5 Other disorders, Hereditary spherocytosis
(haemolytic anaemia due to hereditary
abnormalities of erythrocytes).
“ “
6 Aplastic anaemia and its treatment:, “ “
7 Aplastic anaemia and its treatment:, “ “
8 Polycythemia vera, haemophilia A & B and their
management
“ “
9 Polycythemia vera, haemophilia A & B and their
management
“ “
10 Coagulopathy of liver diseases and its treatment,
Vitamin K deficiency.
“ “
11 Coagulopathy of liver diseases and its treatment,
Vitamin K deficiency.
“ “
12 Disorders of Coagulation “ “
13 Disorders of Coagulation “ “
14 Disorders of Coagulation “ “
15 Basic pharmacology of anti-caogulants,
fibrinolytic, antithrombotic drugs such as,
heparin, warfarin, coumarin streptokinase,
“ “
186
urokinase and tissue plasminogen activator
16 Basic pharmacology of anti-caogulants,
fibrinolytic, antithrombotic drugs such as,
heparin, warfarin, coumarin streptokinase,
urokinase and tissue plasminogen activator
“ “
17 Basic pharmacology of anti-caogulants,
fibrinolytic, antithrombotic drugs such as,
heparin, warfarin, coumarin streptokinase,
urokinase and tissue plasminogen activator
“ “
18 General consideration. Diagnosis clinical findings
and treatment of acute leukemia..
“ “
19 Diagnosis clinical findings and treatment of
chronic myeloid leukemia.
“ “
20 Diagnosis clinical findings and treatment of
chronic lymphatic leukemia
“ “
21 Diagnosis clinical findings and treatment of
chronic lymphatic leukemia
“ “
22 Diagnosis clinical findings and treatment of
lymphocytic leukemia leukemia
“ “
23 Diagnosis clinical findings and treatment of
lymphocytic leukemia leukemia
“ “
24
Diagnosis clinical findings and treatment of Hairy
cell leukemias
“ “
25 Diagnosis clinical findings and treatment of Hairy
cell leukemias
“ “
26 Hyperlipidemia and Hyperlipoproteinemia
Pathophysiology
“ “
27 Hyperlipidemia and Hyperlipoproteinemia
Pathophysiology
“ “
187
28 Normal lipoprotein metabolism. “ “
29 Diseases caused by hyper-lipoproteinemia,
evaluation, indications
“ “
30 Diseases caused by hyper-lipoproteinemia,
evaluation, indications
“ “
31 Therapeutic strategies: Dietary management,
elimination of aggravating factors
“ “
32 Drugs: i) Niacin ii) clofibrate iii) gemfibrozil iv)
fenofibrate v) probucol
“ “
33 Statins and other related drugs, drugs in
combination
“ “
34 Statins and other related drugs, drugs in
combination
188
PCL 713: Neuropharmacology and Endocrinology (Major-X):
COURSE OBJECTIVE:
At the end of the lecture, the student will be able to:
Describe different CNS disorders & treatment.
Describe biosynthesis & therapeutic uses of thyroid hormone, estrogen, adrenocorticotropic hormone,
glucagon, insulin.
Describe treatment of diabetes.
Lecture
No
Title of Lecture Durati
on
Teaching Method
1
The penetration of drugs into CNS after
peripheral administration.
1 hour Lecture/ power
point
2 The penetration of drugs into CNS after
peripheral administration
“ “
3 Metabolism of neuropharmacological agents,
tolerance and physical dependence.
“ “
4 Metabolism of neuropharmacological agents,
tolerance and physical dependence.
“ “
5 Analysis and mode of action of various drugs
acting on CNS
“ “
6 Analysis and mode of action of various drugs
acting on CNS
“ “
7 Biochemical action of the drugs having the effect
on CNS, neuro transmitter system and chemical
pathway in general anaesthetics.
“ “
8 Biochemical action of the drugs having the effect
on CNS, neuro transmitter system and chemical
“ “
189
pathway in
(ii) Local anesthetics (iii) Alcohol abuse
9 Epilepsy “ “
10 Epilepsy
11 Parkinson’s disease “ “
12 Parkinson’s disease
13 Alzehemir’s disease “ “
14 Alzehemir’s disease
15 Opioids Analgesics
“ “
16 Opioids Analgesics
“ “
17 Psychosis:
Antipsychotic drugs.
“ “
18 Antipsychotic drugs.
“ “
19 Schizhophrenia
“ “
20 Schizhophrenia
“ “
21 Bipolar disorder.
“ “
22 Bipolar disorder “ “
23 Phobias.
“ “
24 Phobias. “ “
190
25 Evaluation of psychotropic drugs “ “
26 Evaluation of psychotropic drugs “ “
27 Drug induced behavioural patterns
“ “
28 Drug induced behavioural patterns
“ “
29 Autism,
“ “
30 Autism,
“ “
31 Attention deficit disorder.
“ “
32 Emotional behavior and conditional
neurosis
“ “
33 Learning and discrimination behavior. “ “
34 Learning and discrimination behavior “ “
35 Thyroid hormones and anti thyroid drugs
(Ionic and synthesis inhibitors, radioactive
iodide).
“ “
36 Pharmacological actions, therapeutic
uses and adverse effects of estrogen,
progestin, antiestrogens.
“ “
37 Adenohypophyseal hormones actions and
uses.
“ “
38 Adrenocorticotropic hormones,
therapeutic and diagnostic applications.
“ “
191
39 Insulin and hypoglycemic drugs.
“ “
Reference Books
Emery,s Elements Of Medical Genetics, 13th Edition, Churchill Livingstone.
Molecular Biology Of The Cell, 3rd Edition, Bruce Alberts. Garland Publishing.
Molecular Cell Biology, 4th Edition, by Harvey Lodish.
Bernard Rosner. Fundamentals of Biostatistics, 4th Edition Wadsworth Publishing Company, USA (1995)
Bertram G. Katzung. Basic and Clinical Pharmacology, 11th Edition, A Lange Medical Book. London
Cesare R. Sirtori and others. Clinical Pharmacology. McGraw-Hill, London
Charles R. Craig. Modern Pharmacology, 4th Edition, Little Brown and Company, USA
Clive Page Michael Curtis. Integrated Pharmacology, 2nd Edition, Mosby International Limited. New York.
Curtis D.Klaassen. Casarett & Doull’s Toxicology the basic science of poisons 6th Edition. McGraw Hill
Medical Publishing Division, London.
Daniel Wayne W.Iostatistics: A Foundation for Analysis in the Health Sciences. Fourth Edition. Wiley
Series (1987).
David E. Golan, Armen H. Tashjian, Jr. Ehrin. J Armstrong, April W. Armstrong, Principles of
Pharmacology “The Pathophysiologic Basic of Drug Therapy”. 2nd Edition (2008)
Pharmacology “The Pathophysiologic Basis of Drug Therapy” 2nd Edition (2008)
Desnis N. Jump. MS-DOS Prentice Hall Press, New York (1987)
Elias M. Systems Analysis and Design. Award Galgotia Publication, New Delhi (1989)
Eugenia M. Fulcher, Cathy Dubeansky & Robert M. Fulcher. Pharmacology: Principles and Application: A
Work text for Allied Health Professionals. Saunders, Philadelphia.
Fank C. Lu and Sam Kacew. Basic Toxicology, 4th Edition (2002).
George M. Brenner and Craig W. Stevens. Pharmacology, 2nd Edition (2006)
Goodman & GillMan’s. The Pharses Managmacological Basis of Therapeutics 11th ed. McGraw-Hill, USA.
192
James M. Ritter and Lionel D Lewis. Clinical Pharmacology and Therapeutics, 5th Edition
Joseph T. Dipiro, Pharmacotherapy. A Patho Physiologic Approach. 5th Ed., McGraw-Hill, USA
Judith E. Tintinali. Emergency Medicine, 5th Ed, McGraw-Hill Health Profession Division, USA
Mary Anee Koda Kimble. Applied Therapeutics “The Clinical Use of Drugs” 8th Edition. Lippincott Williams
& Wilkins USA.
Michael D. Rondoll and Karen E Neil. Diseases Management, 1st Edition (2004)
Milton J.S. and Tsokos S.D. Statistical Methods in the biological and health Sciences (1983)
Peter Norton. Inside the IBM PC. Brady Computer Books, New York (1988)
Peter Borton. PC-DOS Prentice Hall Press, New York (1985)
Rang H.P., Dale M.M. Pharmacology, 4th Editions, Churchill Living Stone, England.
Remington R.D. and Schork M.A. Statistics with application to the Biological and Health Science, Prentice
Hall Inc. New Jersey (1985)
Roger Walker and Cate Whittlesea. Clinical Pharmacology and Therapeutics, 4th Edition (2007)
Ronald E. Walpole. Introduction to Statistics, 3rd ed., Macmillan Publishing Co. Inc. New York
Schelfer W.C. Statistics for Biological Sciences, Addison Wesley Pub. Co. Sydney (1979)
Timbrell J.A. Introducton to Toxicology. Taylor & Francis Ltd.
Wardlow A.C Practical Statistics for Experimental Biologists, John Wiley and Sons, New York (1985)
Pennington SR and Dunn MJ, Proteomics: from protein sequence to function, First Indian Edition, 2002.
Daniel C.Liebler, Introduction to Proteomics: Tools for the New Biology, Humana Press, Totowa, New
Jersey, 2002.
A. Malcolm Campell and Laurie J. Heyer, Discovering Genomics, Proteomics & Bioinformatics, Pearson Education, New Delhi, 2004.
FULLTIME TEACHING FACULTY AT DUHS:
1. Prof. Dr. Sumbul Shamim. (B.Pharm., M.Phil., Ph.D) 2. Dr. Noor Jahan. (B.Pharm., M.Phil., Ph.D)
193
3. Dr. Saima Mahmood (B.Pharm., M.Phil., Ph.D) 4. Dr. Shumaila Aman. (B.Pharm., Ph.D) 5. Dr. Mahye Rukh (MBBS., MPhil, PhD) 6. Dr. Mohsin Wahid (MBBS., MPhil, PhD) 7. Dr. Nauman Mughal (MSc., Ph.D.) 8. Dr. Saeed Khan (MSc., M.Phil., Ph.D) 9. Dr. Shaukat Ali. (MSc., M.Phil., Ph.D) 10. Dr. Kashif Shafique, MBBS , MPH , PhD
194
Department of Pharmacy Practice Course scheme-M.Phil
Semester Title of Course Course
Code
No. of Credit
Hrs.
Semester-1
.
Biostatistics (Core-I) PPR 701 3
Research methodology (Core-II) PPR 703 3
Principles of Epidemiology (Core-III) PPR 705 3
Pharmacotherapeutics- I (Major-I) PPR 707 3
Clinical Biochemistry (Major-II) PPR 709 3
15 Credit hrs.
Semester-II
Pharmacotherapeutics- II (Major-III) PPR 702 3
Advanced Clinical Pharmacy Practice
(Major-IV)
PPR 704 2
Regulatory Guidelines In Clinical
Pharmacy Practice (Major-V)
PPR 706 2
Applied Clinical Pharmacokinetics
(Major-VI)
PPR 708 3
Clinical Trial (Major-VII) PPR 710 2
Health Management in Pharmacy
Pratice (Major-VIII)
PPR 712 2
14 Credit hrs.
Semester Title of Course Course
Code
No. of Credit
Hrs.
195
Semester-3
.
Pharmacotherapeutics – III (Major-IX) PPR 711 2
Pharmacovigilance (Major-X) PPR 713 3
Journal Club (Core-IV) PPR 715 1
6 Credit hrs.
Semester-4
.
Research work and Submission of
thesis (Core-V)
PPR 714 6
7 Credit hrs.
Total Credit hours:
Semester-1 Semester-2 Semester-3 Semester-4 Total No. of
Credit Hrs.
15 14 6 6 41
CURRICULUM OF M. Phil (DEPARTMENT OF PHARMACY PRACTICE)
196
SEMESTER- 1
PPR 701- BIOSTATISTICS (CORE-I)
Course Objective
This course is designed to give students experience and confidence in the design and
analysis of data within realistic biological research contexts. Students will gain basic
practical experience in collecting, displaying, summarizing, analyzing and interpreting
biological data in applied research contexts using standard statistical methods.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1 Introduction of Data Organization
(Grouping Data)
1 hour Explain/demonstrate/
assignments/
presentations.
2 Data Organization (Graphs and
Charts
1 hour Explain/demonstrate/
assignments/
presentations.
3 Symbols and Summation Notation
Sample and Population
1 hour Explain/demonstrate/
assignments/
presentations.
4 Measures of Central Tendency 1 hour Explain/demonstrate/
assignments/
presentations.
5 Measures of Dispersion 1 hour Explain/demonstrate/
assignments/
presentations.
6 Probability 1 hour Explain/demonstrate/
assignments/
presentations.
197
7 Probability 1 hour Explain/demonstrate/
assignments/
presentations.
8 Probability 1 hour Explain/demonstrate/
assignments/
presentations.
9 Discrete Probability Distribution: 1 hour Explain/demonstrate/
assignments/
presentations.
10 Discrete Probability Distribution: 1 hour Explain/demonstrate/
assignments/
presentations.
11 Binomial, Poisson and Normal
Distributions:
1 hour Explain/demonstrate/
assignments/
presentations.
12 Binomial, Poisson and Normal
Distributions:
1 hour Explain/demonstrate/
assignments/
presentations.
13 Sampling Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
14 Estimating Means (Large Sample 1 hour Explain/demonstrate/
assignments/
presentations.
15 Hypothesis Testing: One Sample
Test
1 hour Explain/demonstrate/
assignments/
presentations.
16 Hypothesis Testing: One Sample
Test
1 hour Explain/demonstrate/
assignments/
presentations.
17 Hypothesis Testing: One Sample
Test
1 hour Explain/demonstrate/
assignments/
presentations.
198
18 Two Sample Test (Independent
Population)
1 hour Explain/demonstrate/
assignments/
presentations.
19 Two Sample Test (Independent
Population)
1 hour Explain/demonstrate/
assignments/
presentations.
20 Two Sample Test (Independent
Population)
1 hour Explain/demonstrate/
assignments/
presentations.
21 Two Sample Test (Paired And
Proportion)
1 hour Explain/demonstrate/
assignments/
presentations.
22 Two Sample Test (Paired And
Proportion)
1 hour Explain/demonstrate/
assignments/
presentations.
23 Two Sample Test (Paired And
Proportion)
1 hour Explain/demonstrate/
assignments/
presentations.
24 Chi-Square Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
25 Chi-Square Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
26 Chi-Square Distribution 1 hour Explain/demonstrate/
assignments/
presentations.
27 Analysis Of Variance One Way
ANOVA
1 hour Explain/demonstrate/
assignments/
presentations.
28 Analysis Of Variance One Way
ANOVA
1 hour Explain/demonstrate/
assignments/
presentations.
199
29 Analysis Of Variance One Way
ANOVA
1 hour Explain/demonstrate/
assignments/
presentations.
30 Analysis Of Variance Two Way
ANOVA
1 hour Explain/demonstrate/
assignments/
presentations.
31 Analysis Of Variance Two Way
ANOVA
1 hour Explain/demonstrate/
assignments/
presentations.
32 Factorial ANOVA 1 hour Explain/demonstrate/
assignments/
presentations.
33 Factorial ANOVA 1 hour Explain/demonstrate/
assignments/
presentations.
34 Regression, Multiple Regression
And Correlation
1 hour Explain/demonstrate/
assignments/
presentations.
35 Regression, Multiple Regression
And Correlation
1 hour Explain/demonstrate/
assignments/
presentations.
36 Non Parametric Statistics 1 hour Explain/demonstrate/
assignments/
presentations.
37 Non Parametric Statistics 1 hour Explain/demonstrate/
assignments/
presentations.
38 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
39 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
40 Presentation/test/assignments by 1 hour Assignments/
200
students presentations.
Text and Reference Books
Heath, D. An Introduction to Experimental Design and Statistics for Biology, London,
UCL Press, 1995.
Campbell, S. K. Flaws and Fallacies in Statistical Thinking, Prentice-Hall, 1974.
Fisher, R. A. The Design of Experiments. Hafner, 1971.
Gonick, L. and Smith, W. The Cartoon Guide to Statistics. Harper Perennial, 1993
Moses, L. E. Think and Explain with Statistics. Addison Wesley, 1986.
Salsburg, D. S. Understanding Randomness. Lecture Notes in Statistics, Vol. 6 Marcel
Dekker, 1983.
Sokal, R. R. and F. J. Rohlf. Introduction to Biostatistics, 2nd
, 3ed. Freeman, 1987.
Zar, J. Biostatistical Analysis. Prentice Hall, 1984.
Course Title
PPR 703- RESEARCH METHODOLOGY (CORE-II)
The objectives of the course are:
To provide students with the tools and skills required to understand research terminology
and assess published research; to identify the types of methods best suited for
investigating different types of problems and questions, to design a research proposal and
to begin initial preparations for embarking on a new research project.
Syllabus breakdown in lectures (As per table given below)
Lecture
No
Title of Lecture Duration Teaching Method
1
Introduction 1 hour Explain/demonstrate/
assignments/
presentations.
2
Research Objective
1 hour Explain/demonstrate/
assignments/
presentations.
3 Selection of the area of research
1 hour Explain/demonstrate/
assignments/
presentations.
201
4 Selection of the area of research
1 hour Explain/demonstrate/
assignments/
presentations.
5 Selection of research
guide/supervisor
1 hour Explain/demonstrate/
assignments/
presentations.
6 Selection of research
guide/supervisor
1 hour Explain/demonstrate/
assignments/
presentations.
7 Selection of topic/ problem
1 hour Explain/demonstrate/
assignments/
presentations.
8 Selection of topic/ problem
1 hour Explain/demonstrate/
assignments/
presentations.
9 Selection of topic/ problem
1 hour Explain/demonstrate/
assignments/
presentations.
10 Construction of a strong statement
that summarizes the selected topic.
1 hour Explain/demonstrate/
assignments/
presentations.
11 Construction of a strong statement
that summarizes the selected topic.
1 hour Explain/demonstrate/
assignments/
presentations.
12 Sources of information
1 hour Explain/demonstrate/
assignments/
presentations.
13 Books, journals/periodicals, old
testimonials.
1 hour Explain/demonstrate/
assignments/
presentations.
202
14 News papers, internet; proceedings
of conferences
1 hour Explain/demonstrate/
assignments/
presentations.
15 Seminars, workshops and training
programs; conversations
1 hour Explain/demonstrate/
assignments/
presentations.
16 Detail of Equipments/ Fields/ Area
1 hour Explain/demonstrate/
assignments/
presentations.
17 Type of Instruments: Models, make
and country of origin;
1 hour Explain/demonstrate/
assignments/
presentations.
18 Validation: reliability and accuracy 1 hour Explain/demonstrate/
assignments/
presentations.
19 Service centers, availability of
supplies and engineers; Environment:
laboratory conditions.
1 hour Explain/demonstrate/
assignments/
presentations.
20 Service centers, availability of
supplies and engineers; Environment:
laboratory conditions
1 hour Explain/demonstrate/
assignments/
presentations.
21 Plan of work 1 hour Explain/demonstrate/
assignments/
presentations.
22 Collection of material/authentication
1 hour Explain/demonstrate/
assignments/
presentations.
23 Collection of material/authentication
1 hour Explain/demonstrate/
assignments/
presentations.
203
24 Preliminary screening/pilot plan
1 hour Explain/demonstrate/
assignments/
presentations.
25 Preliminary screening/pilot plan
1 hour Explain/demonstrate/
assignments/
presentations.
26 Experimental: detailed procedure 1 hour Explain/demonstrate/
assignments/
presentations.
27 Experimental: detailed procedure 1 hour Explain/demonstrate/
assignments/
presentations.
28 Experimental: detailed procedure 1 hour Explain/demonstrate/
assignments/
presentations.
29 Places for practical work and
resources
1 hour Explain/demonstrate/
assignments/
presentations.
30 Places for practical work and
resources
1 hour Explain/demonstrate/
assignments/
presentations.
31 Places for practical work and
resources
1 hour Explain/demonstrate/
assignments/
presentations.
32 Places for practical work and
resources
1 hour Explain/demonstrate/
assignments/
presentations.
33 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
34 Result Compilation 1 hour Explain/demonstrate/
204
assignments/
presentations.
35 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
36 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
37 Result Compilation
1 hour Explain/demonstrate/
assignments/
presentations.
38 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
39 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
40 Presentation/test/assignments by
students
1 hour Assignments/
presentations.
Text and Reference Books
Luker, K. (2010). Salsa dancing into the social sciences. Cambridge, MA: Harvard
University Press. (ISBN 9780674048218).
Knight, P.T. (2002). Small-scale research. Thousand Oaks, CA: Sage Publications (ISBN-
10: 0761968628 / ISBN-13: 978-0761968627).
Myers, Michael D. "Qualitative Research in Information Systems”, AISWorld Section on
Qualitative Research, www.qual.auckland.ac.nz
Myers, Michael D., and David Avison (eds.). Qualitative Research in Information
Systems: A Reader. Sage Publications, 2002.
Lee, A.S., Liebenau, J. and DeGross, J.I. (eds.). Information Systems and Qualitative
Research, Chapman and Hall, London, 1997.
Yin, Robert K. Case Study Research: Design and methods. Third edition. Sage Publications,
2003.
Walsham, G. Interpreting Information Systems in Organizations. John Wiley and Sons,
Chichester, 1993.
Wolcott, H. Writing up Qualitative Research. Sage Publications, Thousands Oaks, CA, 1990.
205
PPR 705: PRINCIPLES OF EPIDEMIOLOGY (Core-III)
At the end of the lecture, the student will be able to:
Define Epidemiology, disease Transmission.
Explain Measuring the occurrence of disease: Morbidity and Mortality, Assessing the
Validity and Reliability of diagnostic and screening tests.
Identify the roles of genetic and environmental factors in disease causation,
Evaluate health services by Epidemiology.
Lecture
No
Title of Lecture
Duratio
n
Teaching Method
1
Introduction
1 hour Lecture/ power point
2 The dynamics of disease Transmission
“ “
3 The dynamics of disease Transmission
“ “
4 Measuring the occurrence of disease:
Morbidity and Mortality
“ “
5 Measuring the occurrence of disease:
Morbidity and Mortality
“ “
6 Measuring the occurrence of disease:
Morbidity and Mortality
7 Assessing the Validity and Reliability of
diagnostic and screening tests
“ “
8 Assessing the Validity and Reliability of
diagnostic and screening tests
“ “
9 Assessing the Validity and Reliability of
diagnostic and screening tests
“ “
10 Understanding biases and confounding “ “
11 Understanding biases and confounding “ “
12 Cohort Studies “ “
13 Cohort Studies “ “
14 Case-Control Studies and other study
designs
“ “
15 Comparing Cohort and Case-Control “ “
206
Studies
16 Comparing Cohort and Case-Control
Studies
“ “
17 Indentifying the roles of genetic and
environmental factors in disease causation
“ “
18 Indentifying the roles of genetic and
environmental factors in disease causation
“ “
19 Using Epidemiology to evaluate health
services
“ “
20 Using Epidemiology to evaluate health
services
“ “
21 The epidemiologic approach to evaluating
screening programs
“ “
22 Epidemiology and public policy “ “
23 Epidemiology and public policy “ “
24 Measure of association I (Relative
risk/odds ratio/ standardized mortality
ratios/Attributable risk)
“ “
25 Measure of association I (Relative
risk/odds ratio/ standardized mortality
ratios/Attributable risk)
26 Ethical and professional issues in
Epidemiology
“ “
27 Ethical and professional issues in
Epidemiology
“ “
28 Investigation of disease outbreak “ “
29 Investigation of disease outbreak “ “
30 Causal inference “ “
31 Causal inference “ “
PPR- 707 Pharmacotherapeutics- I (Major-I)
At the end of this course, the student should be able to:
Describe the underlying pathophysiology and describe the basis of pharmacotherapy of
these diseases including dosage calculation, adverse reactions, drug interactions,
alternative therapies and monitoring parameters.
207
List a possible management plan of adverse reactions and interaction of pharmacotherapy
observed.
Apply evidence-based medicine to identify the limitation and benefits of the
pharmacotherapy to individual patient.
Diseases includes: Endocrine and reproductive: hypo and hyperthyroidism, contraceptive
drugs, diabetes mellitus, osteoporosis, adrenal diseases, rheumatoid arthritis and
osteoarthritis.
Sr. No Topic Duration Teaching
Method
1
Thyroid hormones and anti thyroid drugs
(Ionic and synthesis inhibitors, radioactive
iodide).
2 hour Lecture/
power point
2 Pharmacological actions, therapeutic uses and
adverse effects of estrogen, progestin,
antiestrogens.
“ “
3 Adenohypophyseal hormones actions and
uses.
“ “
4 Adrenocorticotropic hormones, therapeutic
and diagnostic applications.
“ “
5 Diabetes mellitus
6 Insulin and hypoglycemic drugs. “ “
7 Osteoporosis
8 Rheumatoid arthritis and osteoarthritis
PPR-709 CLINICAL BIOCHEMISTRY (Major-II)
The students will be able to
Demonstrates an in-depth knowledge of the molecular and cell biology of cancer, AIDS,
etc.
Facilitate research skills relevant to the field
Explain the use of biochemical tests their significance and interpretation in clinical
situations.
Discuss the biochemistry ageing and enviroment.
Elaborate biophysics‟ principles and importance
Breiefly discuss applied molecular medicine
208
Sr.
No
Topic Duration Teaching Method
1 Renal Function Test 2 hour Lecture/ power point
2 Liver Function Test “ “
3 Gastric Function Test “ “
4 Tyroid Function Test “ “
5 Enzyme and isoenzymes : Clinical Improtance “ “
6 Enviromental Biochemistry “ “
7 Biochemistry of Cancer “ “
8 Biochemistry of AIDs “ “
9 Biochemisty of Ageing “ “
10 Biophysics: principles and importance “ “
11 Radioisotopes in Medicines “ “
12 Introduction of Molecular medicine “ “
13 Applied aspets of Acid Base Balance and water
electrolyte balance
“ “
14 Biotansforamtion and xenobiotics “ “
SEMESTER- 2
PPR-702 Pharmacotherapeutics- II (Major-III)
At the end of this course, the student should be able to:
Describe the underlying pathophysiology and describe the basis of pharmacotherapy of
these diseases including dosage calculation, adverse reactions, drug interactions,
alternative therapies and monitoring parameters.
List a possible management plan of adverse reactions and interaction of pharmacotherapy
observed.
Apply evidence-based medicine to identify the limitation and benefits of the
pharmacotherapy to individual patient.
Diseaes includes: Cardiovascular: ischemic heart diseases, congestive heart failure,
hypertension, cardiac arrhythmia, Respiratory: bronchial asthma, chronic obstructive
airway disease, bronchitis, bronchiolitis, cystic fibrosis, pulmonary hypertension.
Lecture
No
Topic Duration Teaching
Method
1
Hypertension Hypertension and
regulation of blood pressure: Definition,
classification, etiology,
2 hour Lecture/ power
point
2 Antihypertensive Drugs Classification of
drugs,.
“ “
209
3 Mechanism, pharmacological effects, side
effects, adverse effects etc. of the drugs
e.g. Diuretics, sympatholytics,
vasodilators, ACE inhibitors.
“ “
4 Angina Pectoris Pathophysiology of
angina. Determination of myocardial
oxygen demand.
“ “
5 Myocardial infarctin, Drugs e.g. coronary
dilators, nitrates, calcium blocking agents.
“ “
6 Non-Pharmacological Therapy “ “
7 Etiology of arrhythmias, its types and
associated complications, Anti arrhythmic
drugs.
“ “
8 Etiology of stroke, risk factors, “ “
9 Treatment strategies of Cerebral ischemia
and risk evaluation
“ “
10 Antiplatelet and anticoagulant drugs with
rationalization of use in I.H.D,
“ “
11 Drugs used in Asthma and COPD “ “
12 Allergic Rhinitis and Cough “ “
13 Cystic fibrosis, pulmonary hypertension.
PPR-704 Advanced Clinical Pharmacy Practice (Major-IV)
Students will study the scientific and clinical factors that influence treatment with medicines and
the delivery of pharmaceutical care. Advanced training in the practice of clinical pharmacy
enables students to judge new treatments critically and to extend clinical services. This course
builds on the limited knowledge imparted in some undergraduate courses, whilst underpinning
that acquired professionally.
At the end of the course, the students should be able to:
1. Describe various clinical activities in extended pharmaceutical care
2. Describe resources of information and their management
3. Explain clinical pharmacist specialist board certification.
4. Describe difference between clinical pharmacist and clinical pharmacist specialist.
5. Define evidence based practice and explain implementation.
6. Discuss procedure of critical appraisal.
210
7. Describe formulary and explain the role of clinical pharmacist in formulary management.
Sr. No Topic Duratio
n
Teching
Method 1) Introduction 2 hour Lecture/
power point 2) Critical Activates Extended Pharmaceutical
Care “ “
3) Critical Activates Extended Pharmaceutical
Care “ “
4) Critical Activates Extended Pharmaceutical
Care “ “
5) Information Resources & Their Management “ “ 6) Information Resources & Their Management “ “ 7) Board Certification Of Clinical Pharmacist “ “ 8) Board Certification Of Clinical Pharmacist “ “ 9) Difference B/W Clinical Pharmacist & Clinical
Pharmacist Specialist “ “
10) Difference B/W Clinical Pharmacist & Clinical
Pharmacist Specialist “ “
11) Evidence Based Practical & Its Implementation “ “ 12) Evidence Based Practical & Its Implementation “ “ 13) Introduction To Critical Appraisal “ “ 14) Procedure Of Critical Appraisal “ “ 15) Procedure Of Critical Appraisal “ “ 16) Procedure Of Critical Apprairal “ “ 17) Formulary & Formulary System “ “ 18) Role Of Clinical Pharmacist Informatory
Management “ “
PPR 706 REGULATORY GUIDELINES IN CLINICAL PHARMACY PRACTICE
(Major-V)
The students will be able to
Know and explain key differences between laws/regulations or rules and pharmacy
professional practice standards/ethical principles.
Identify the function of pharmacy laws and regulations or rules.
Discuss how professional standards and ethical principles impact your practice
Compare and contrast the processes required to establish laws, regulations, professional
practice standards, and ethical principles.
Describe the different legal systems that could be involved for a legal dispute or a
violation of a pharmacy law and/or regulation.
Sr. No Topic Duration Teaching
Method
211
PPR 708 Applied Clinical Pharmacokinetics (Major- VI)
Upon completion of the course, students should be able to:
1.Use patient data and PK-PD principles to determine optimal pharmacotherapy including drug
dosing to maximize efficacy and minimize toxicity
2.Recognize and manage, through appropriate drug dosing, pharmacokinetic variability in
patients with significant alterations due to physiology or disease (eg, age, pregnancy, obesity,
malabsorption, organ dysfunction, critical illness)
3.Recognize and manage clinically significant actual and potential pharmacokinetic drug
interactions in patients
4.Perform therapeutic drug monitering (TDM) in patients receiving medications for which
concentrations can be measured in practice (eg anti-infectives, anticonvulsants, cardiac
1) Introduction 2 hour Lecture/
power point 2) Differences B/W Laws & Pharmacy
Professional Practices “ “
3) Differences B/W Laws & Pharmacy
Professional Practices “ “
4) Function Of Pharmacy Rules & Regulatory “ “ 5) Function Of Pharmacy Rules & Regulatory “ “ 6) Impact Of Professional Standard & Ethical
Principle On Pharmacy Practices “ “
7) Impact Of Professional Standard & Ethical
Principle On Pharmacy Practices “ “
8) Processes For Establishing Laws, Regulation
& Professional Praceties,Standard & Etrical
Principles
“ “
9) Processes For Establishing Laws,Regulation
& Professional Praceties,Standard & Etrical
Principles
“ “
10) Processes For Establishing Laws,Regulation
& Professional Praceties,Standard & Etrical
Principles
“ “
11) Processes For Establishing Laws,Regulation
& Professional Praceties,Standard & Etrical
Principles
“ “
12) Introduction To Deferent Legal System For
Legal Dispute Or Violation Of Pharmacy
Laws
“ “
13) Introduction To Deferent Legal System For
Legal Dispute Or Violation Of Pharmacy
Laws
“ “
14) Introduction To Deferent Legal System For
Legal Dispute Or Violation Of Pharmacy
Laws
“ “
212
medications, psychiatric medications, immunosuppressants) or predicted from population-PK
data.
Sr.no. Topic Duration Methodology
1 Phramacokinetic-
pharmacodynamic principals
2 hours Lecture/ power
point
2 Pharmacokinetic variability in
patients and dose calculation
6 hours “
3 Pharmacokinetic drug interactions 4 hours “
4 Therapeutic drug monitering “ “
5 Use of software for simmulation
of serum drug profile in different
pharmacokinetic models
“ “
Books:
1. Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition (Shargel, Applied
Biopharmaceuticals & Pharmacokinetics) Hardcover – May 2, 2012 by Leon
Shargel (Author), Andrew Yu (Author), Susanna Wu-Pong (Author), McGraw-Hill
Education / Medical; 6 edition (May 2, 2012).
PPR710 CLINICAL TRIALS (Major-VII)
covers fundamental concepts and basic analytic methods pertaining to the design, analysis, and
interpretation of clinical research studies. designed to help professionals gain the understanding
of the entire clinical trials process--from drug and device development to monitoring and post
marketing activities as well as relevant information vitally important to the conduct of clinical
research.
The students will be able to
1. Demonstrate a foundational understanding of clinical research methodologies described in
study protocols with emphasis on study design, operational aspects, and regulatory compliance
2. Describe various approaches to data collection and Interpret statistical results from the
published studies in the peer reviewed literature and clinical study reports
3. Incorporate and prioritize the protection of human subjects and other ethical considerations in
all aspects of clinical research
4. Describe sources for regulations, guidance, and best practices commonly used in the conduct
of clinical trials and postmarketing studies in the US and abroad
5. Write, communicate, and interact effectively in a professional environment as an entry-level
professional
213
6. Think critically when planning or evaluating a research study, complex operational endeavor,
or ethical dilemma
S.NO Topic NO. OF
LECTURES
Teaching
Method
1 Introduction 3 Lecture/
power point
2 Clinical Research Regulations and ethics 8 “
3 Research Protocol Design 5 “
4 Clinical Research Management
5 “
5 Clinical Data and its management 3 “
6 Research Site Management 5 “
7 Data Trends and Reporting 3 “
8 Budgeting and funding 3 “
9 Pharmacovigilance 1 “
10 FDA inspections 2 “
38 “
PPR712 Health Management in Pharmacy Practice (Major-VIII)
The students will be able to
Describe Health Services System
Explain Health Services System
Discuss Legal Aspects of Health Care
Elaborate Health Care Marketing
Provide Quality Management in Health Care
Sr.NO Topic NO. OF
LECTURES Teaching
Method
1 Introduction 2 Lecture/
power
point
2 Health Services System 3 “
3 Health Services System 4 “
214
4 Managed Care and the Industrial Organization of Health Care
4 “
5 Health Policy 2 “
6 Health Services Delivery 2 “
7 Legal Aspects of Health Care 2 “
8 Management of Health Care for the Elderly 4 “
9 Quality Management in Health Care: Emergency Response
Services
2 “
10 Health Care Marketing 3 “
11 Comparative Health Care Systems
2 “
12 Management and Economics of Pharmaceutical, Biotech and
Medical Device Industries
3 “
13 E-Health: Business Models and Impact
3
14 Health Care Entrepreneurship
2
15 Private Sector Role in Global Health 2
40
SEMESTER-3
PPR711 Pharmacotherapeutics- III (MajorIX)
At the end of this course, the student should be able to:
Describe the underlying pathophysiology and describe the basis of pharmacotherapy of
these diseases including dosage calculation, adverse reactions, drug interactions,
alternative therapies and monitoring parameters.
List a possible management plan of adverse reactions and interaction of pharmacotherapy
observed.
Apply evidence-based medicine to identify the limitation and benefits of the
pharmacotherapy to individual patient.
Diseaes inclues: Immunodeficiency Diseases, Autoimmunity, Immunology of HIV
Infections, antimicrobials.
215
Students will learn how to o design geriatric and paediatric patient drug therapy through
problem solving sessions.
Sr.No Topic Duration Teaching
Method
1 Establishing presence/ severity of infection. 2 hour Lecture/ power
point
2 Antimicrobials/ choices based on culture
sensitivity/ severity.
“ “
3 Infections of different systems with drug of
choices.
“ “
4 Fungal infection/ mycoses/ aspergillosis/
histoplasmosis (anti fungal agents)
“ “
5 Parasitic infections/ malaria/ amebiasis/
giardiasis/ scabies. (Drug treatment and
choices).
“ “
6 Spirochete infections/ rickettesial infections
(treatment and choices of agents.)
“ “
7 Antivirals. “ “
8 Immunodeficiency Diseases “ “
9 Autoimmunity “ “
10 Immunology of HIV Infections “ “
11 Geriatric patient drug therapy,
pharmacokinetics, pharmacodynamics,
common disorders.
“ “
12 Paediatric patient drug therapy,
pharmacokinetics, Congenital anomalies,
medicines in school, monitering program..
“ “
PPR713 PHARMACOVIGILANCE (Major-X)
The students will be able to
Define and explain different aspects and importance of:
Adverse drug reactions and its classification
Limitations of phase I, II and III clinical trials
Identify the populations at risk of ADRs
216
Know and understand the Challenges posed by non-prescribed agents, e.g. herbal
preparation use
Know and explain regarding ADR reporting
Discuss about the National and International Regulations covering WHO, CIOMS, ICH,
etc
Sr.No Topic Duration Teaching
Method 1) Introduction 2 hour Lecture/
power point 2) Introduction “ “ 3) ADR‟s Introduction “ “ 4) Classification Of ADR‟s “ “ 5) Population At Risk Of ADR‟S “ “ 6) ADR‟sreporting & Monitory “ “ 7) ADR‟sreporting & Monitory “ “ 8) Clinical Trical & Its Limitation For Phase
1‟2‟3 “ “
9) Clinical Trical & Its Limitation For Phase
1‟2‟3 “ “
10) Challenges For Pharmacist Posed By Non-
Prescribed Agent E.G : Herbal Preparation “ “
11) Challenges For Pharmacist Posed By Non-
Prescribed Agent E.G : Herbal Preparation “ “
12) Introduction To National & International
Regulation “ “
13) Introduction To National & International
Regulation “ “
14) Introduction To National & International
Regulation “ “
List of Full Time Teaching Faculty at Faculty of Pharmaceutical
Sciences
Department of Pharmacy Practice:
6. Prof. Dr. Sumbul Shamim. B. Pharm., M.Phil., PhD 7. Dr. Hafiz M. Arshad, B. Pharm., M.Phil., PhD 8. Dr. Najia Raheem , B. Pharm., M.Phil., PhD. 9. Dr. Fakhsheena Anjum, B. Pharm., M.Pharm., PhD. 10. Dr. Kashif Shafique, MBBS , MPH , PhD