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DRUGS ARE LISTED BY GENERIC NAME 1/100 = 1% = 10mg/ml , 1/1000 = 1mg/ml , 1/10000 = 0.1mg/ml

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o Abacavir sulphate . 8mg / kg / dose (adult 300mg) 12H oral. o Abciximab . 0.25mg / kg IV stat 10min before angioplasty. o Acamprosate calcium . Adult (NOT/kg) . <60kg: 666mg mane , 333mg noon , 333mg nocte oral . >60kg : 666mg 8H . o Acarbose. 1 - 4 mg / kg / dose (adult 50-200mg) 8H oral . o Acebutolol. 4-8mg / kg / dose (adult 200-400mg) 8-24H oral o Aceclofenac . 2mg / kg / dose (adult 100mg) 12H oral. o Acemetacin . 1.2mg / kg / dose (adult 60mg) 8-12H oral. o Acetaminhopen . see Paracetamol . o Acetazolamide . 5-10mg / kg / dose (adult 100-250mg) 6-8H (daily for epilepsy) oral. o Acetohydroxamic acid . 5mg / kg / dose (adult 250mg) 6 - 8H oral . o Acetylcholine chloride . Adult (NOT/kg) : 1% instil 0.5-2ml into anterior chamber of the eye. o Acetyl sulfisoxasole . 1.16g = 1.0g sulphafurazole (qv). o Acetylcysteine . Paracetamol poisoning (regardless of delay) ; 150mg / kg in 5% D IV over 1hr ; then 10mg / kg / hr for 20hr (delay < 10hr0, 32hr (delay 10-16hr), 72hr (delay >16hr) and longer

if still encephalopathic ; oral 140mg / kg stat, then 70mg / kg / dose 4H for 72hr . Monitor serum K- Give if Paracetamol > 1000umol/L (150mg/L) at 4hr, >500umol /L 8hr , >250umol/L 12hr . lung disease : 10% soltn 0.1ml / kg / dose (adult 5ml) 6-12H nebulised or intra tracheal . Meconium ileus equivalent : 5ml/dose (NOT/kg) of 20% soltn 8H oral ; 60-100ml of 50mg/ml for 45min PR . CF : 4-8mg / kg dose 8H oral.Eye drops 5% + hypromellose 0.35% 1-2 drops/eye 6-5H.

o Acetylsalicylic acid . See aspirin . o Aciclovir . Neonate to 12wk : 20mg / kg / dose IV over 1hr daily ( < 30 wk gest). 18H ( 30 - 32 wk). 12H ( 1st wk life). 8H ( 2 -12 wk) for 2 wk (3wk for encephalitis). EB virus , herpes encephalitis ,

immunocompromissed , or varicella ( > 12wk old ) : 500mg / m2 / dose ( adult 10mg / kg ) 8H IV over 1hr . cutaneous herpes ( > 12wk old ) : 250mg /m2 / dose (12wk - 12yr ), 5mg / kg / dose (adult ) 8H IV over 1hr . genital herpes (NOT / kg ): 200mg / dose oral x5 /day for 10 days , then 200mg / doswe x2 - 3 / day for 6mo if reqd. Zoster ( NOT /kg ) :400mg / dose (<2yr ) or 800mg / dose ( > = 2yr ) oral x5 /day for 7 days . Cold sores : apply 5% cream x5 /day . Eye : apply 3% oint x5/day.

o Acipimox . 5mg / kg / dose (adult 250mg) 8-12H oral . o Acitretin . 0.5-1mg / kg (adult 250mg) 8-12H oral . o Acriflavine hydrochloride . 0.1% soltn : apply 12-24H. o Acrivastine . 0.15mg / kg / dose (adult 8mg) 8H oral. o Actinomycin D . See dactinomycin. o Activated charcoal . See charcoal , activated. o Acyclovir . See aciclovir. o Adapalene . 0.1% gel : apply once a day before bedtime. o Adenosine . 0.1mg / kg (adult 3mg) stat rapid IV push , incr by 0.05mg / kg (adult 3mg) every 2min to max 0.35mg / kg (adult 18mg). o Adrenaline . Croup : 1% ( L isomer ) or 2 - 25% ( racemic ) 0.05 ml / kg / dose diluted to 4ml by inhaltn ; or 1/1000 0.5 ml / kg / dose (max 6ml) by inhaltn . Cardiac arrest (repeat if reqd) : 0.1ml

/ kg of 1/10,000 IV or intracardiac ; via ETT 0.1ml / kg of 1/1000. Anaphylax : 0.05 - 0.1ml / kg / dose of 1/10,000 IV , repeat reqd . SC:0.01mg/kg (0.01ml/kg of 1/1000) up to 0.1mg/kg , x3 doses 20min aprt if reqd . IV infsn 0.052mcg/ kg/ min : child see p.47 ; for 65kg adult 5mg in 50ml at 2ml/hr is 0.05mcg/ kg / min.

o Adrenocorticotrophic hormone ( ACTH) . See corticotrophin. o Agar . See paraffin (and phenolphthalein) and agar.

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o Alatrofloxacin . 4mg / kg (adult 200mg) daily IV over 60mon. o Albendazole . Pinworm , threadworm , roundworm , hookworm whipworm : 20mg / kg (adilt 400mg) oral once (may repeat after 2wk). strongyloides , cutaneous larva migrans, Taenia , H.nana

, O. vivirrini , C.sinessis : 20mg / kg / dose (adult 400mg) 12H for 8-30 days (neurocysticercosis) ; 12H for three 28day courses 14 days apart (hydatid). o Albumin . 20% : 2 - 5ml / kg IV . 4% : 10 - 20ml / kg . if no loss from plasma : dose (ml/kg) = 5 x (increase g/l) / (% albumin). o Albuterol . See salbutamol. o Alclometasone dipropionate . 0.05% cream or ointment ; apply 8-12H. o Aldesleukin (synthetic IL-2) . See interleukin - 2. o Alemtuzumab . Adult (NOT/kg) : 3mg daily IV over 2hr5 for 2-3days , then 10mg daily for 2-3 days , then 30mg x3/wk for up to 12wk. o Alendronate. Adults (NOT/kg) , oral Osteoporosis 10mg dayli ; slow release 35mg weekly (prevention), 70mg weekly (treatment). Paget's 40mg daily. o Alfacalcidol . 0.05mcg / kg (max 1mcg) daily oral or IV , adjusted according to response. o Alfentanil hydrochloride . 10mcg / kg IV or IM stat, then 5mcg / kg prn. Theatre (ventilated); 30-50mcg / kg IV over 5min , then 15mcg/ kg prn or 0.5-4mcg / kg min. o Alfuzosin . 0.05mg / kg / dose (max 2.5mg) 6-12H oral. o Alginic acid (Gaviscon single strength) . <1yr : liquid 2ml with feed 4H. 1-12yr ; liquid 5-10ml, or 1tab after meals. >12yr : liquid 10-20ml , or 1-2 tab after meals. o Alglucerase . usual initial dose is 60u/kg every 2wk IV over 2hr, adjusted according to response; reduce every 3-6mo. o Alitretinoin . 0.1% gel; apply 6-12H. o Allopurinol . 10mg / kg / dose (adult 300mg) 12 - 24 H oral , or (chemotgerapy) 50 -100mg / m2 / dose 6H IV , oral. o Almotriptan . adult (NOT/kg): 6.25-12.5mg oral, repeat in 2hr if reqd (max 2 doses in 24hr). o Alosetron . adult (NOT/kg): 1mg daily oral , incr if reqd after 4wk to 1mg / dose 12H (stop if no response after 4wk). o Alpha,proteinase inhibitor . See alpha , antitrypsin. o Alpha antitrypsin . 60mg / kg once weekly IV over 30min. o Alpha tocopheryl acetate . One alpha- tocopheryl (at) equivalent= 1mg d-at =1.1mg d-at acetate=1.5mg dl-at acetate=1.5u vit E . Abetalipoproteinaemia: 100mg/kg (max 4g) daily oral . Cystic

fibrosis: 45-200mg (NOT/kg) daily oral .Newborn (highdose,toxity reported):10-25mg/kg daily IM or IV,10-100mg/kg daily oral . o Alprazolam . 0.005-002mg/kg/dose (adult 0.25-1mg)8H oral. o Alprenolol . 1-4mg/kg/dose (max200mg)6-12H oral. o Alprostadil (prostaglandin E1 , PGE 1). To maintain PDA : 0.01 - 0.1 mcg / kg / min (10 - 100ng / kg / min); for 0.01 mcg / kg / min (10ng / kg / min), put 60 mcg / kg in 50ml saline, run at 0.5 /

ml/hr. pul vasodil with o mcg / kg / min (100ng / kg / min0,put 500mcg in 83/wt ml saline and run at 1ml/hr (5.0mcg/ kg / min nitroglyc = 2.0mcg / kg / min nitropr - 0.1mcg / kg / min PGE1 approx). Erectile

dysfunction 9adult o NOT/kg):2.5mcg intracavernous inj, incr in 2.5mcg increments if reqrd to max 60mcg (max of 3doses/wk). o Alteplase (tissue plasminogen activator) . 0.1-0.6mg / kg / hr IV for 6-12hr (longer if no response); keep fibrinogen >100mg/dl (give cryoprecipitate 1bag / 5kg),give heparin 10u / kg /hr IV,give

fresh frozen plasma (FFP) 10ml/kg IV daily in infannts. Local IA infsn 0.05mg/kg/hr,give FFP 10ml/kg IV daily. Blocked central line : 0.5mg/2ml(<10kg)2mg/ 2ml (>10kg) per lumen left for 2-4hr, with draw drug, flush withsaline; repeat once in 24hr if reqd.

o Altretamine . 150-300mg/m2 daily oral. o Aluminium acetate . 13% soltn (Burrow's lotion): for wet compresses, or daily to molluscum contagiosum. o Aluminium chloride hexahydrate . 205 lotion : daily at night for 1wk, then x1-2/wk. o Aluminium hydroxide . 25mg / kg / dose (adult 0.5-1g) 4-6H oral. Gel (64mg/ml) 0.1 ml/kg/dose 6H oral . o Aluminium hydroxide .40mg/ml, magnesium hydroxide 40mg/ml, simethicone 4mg/ml (Mylanta, gelusil). 0.5- 1ml/kg/dose (adult 10-20ml) 6-8H oral. ICU:0.5ml/kg/dose 3H oral of gastric pH

<5. o Aluminium sulphate. 20% soltn: apply promptly to sting. o Alverine . 1-2mg/kg/dose (adult 60-120mg) 8H oral.

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o Amantadine hydrochloride . 2mg/kg/dose (adult 100mg) 12-24H oral. Flu A prpphylaxis (NOT/kg): 100mg daily (5-9yr). 100mg 12H (>9yr). o Amcinodine . 0.1% lotion, cream, ointment: apply 8-12H. o Amethocaine . Gel 4% in methylcellulose (RCH An Gel): 0.5g to skin, apply acclusivedressing, wait 20-60min, remove gel. 0.5%, 1%: 1-2 drops/eye. o Amifostine . 910mg/m2 IV over 15min daily 30min before chemoteraphy; reduce to 740mg/m2 if severe side effects. o Amikacin . single daily dose IV or IM. Neonate; 15mg/kg stat, then 7.5mg/kg (<00wk)10mg/kg (30-50wk) 15mg/kg (term < 1wk) daily. 1wk-10yr: 25mg/kg day 1, then 18mg/kg daily. >10yr:

20mg/kg day 1, then 15mg/kg (max 1.5g) daily. Trought level <5.0mg/L (RCH sent to St. V's). o Amiloride . 0.2mg/kg/dose (adult 5mg) 12-24H oral. o Aminoacridine hydroclhoride . See aminacrine. o Aminacrine hydroclhoride . 0.02% 1-2 drops/eye 2-4H. o Aminobenzoic acid . 60mg/kg/dose (max 3g) 6H oral. o Aminocaproic acid . 3g/m2 (adult 5g0 over 1hr IV, then 1g/m2/hr (adult 1-1.25g/hr).Prophylaxys: 70mg/kg/dose 6H IV, oral. o Aminogluthetimide . Adult: 250mg (NOT/kg) daily oral, incr over 4wk to 250mg 6H. o Aminohippuric acid (PAHA). 6-10mg/kg stat, then 0.2-0.5mg/kg min IV gives 2mg/100ml in plasma. o Aminolevulinic acid. 20% soltn; apply to lesions, expose to 400-450nm blua light for 1000sec (10 J/cm2) next day; repeat after 8wk if reqd. o Aminophylline (100mg aminophylline - 80mg theophylline). Load: 10mg/kg (max 500mg) IV over 1hr. Maintenance: 1st wk life 2.5mg/kg/dose 12H; 2nd wk life 3mg/kg/dose 12H; 3wk-12mo

(0.12x age in wk)+3) mg/kg/dose 8H; 1-9yr 1.1mg/kg/hr (55mg/kg/in 50ml at 1ml/hr), or 6mg/kg/dose IV over 1hr 6H; 10-16yr or adult smoker 0.7mg/kg/hr (<35kg 35mg/kg in 50ml at 1ml/hr; >35kg 25mg/ml at 0,028ml/kg/hr), or 4mg/kg/dose IV over 1hr 6H; adult non - smoker 0.5mg/kg/hr (25mg/ml at 0.02ml/kg/hr). or 3mg/kg/dose IV over 1hr 6H; elderly 0.3mg/kg/hr (15mg/kg in 50ml at 1ml/hr), or 2mg/kg/dose IV over 1hr 6H. Monitor theophylline level; 60-80umol/L (neonate), 60-11- (asthma) (x 0.18 =mcg/ml).

o Aminosalicyllic acid (4- Aminosalicyllic acid, ASA, 4-ASA, para-ASA, PAS). 50-100mg/kg/dose (adult 4g 8H oral. o 5 - Aminosalicyllic acid . See mesalazine. o Amiodarone . IV: 25mcg/kg/min for 4hr, then 5-15mcg/kg/min (max 1.2g/24hr), Oral: 4mg/kg/dose (adult 200mg) 8H 1wk, 12H 1wk, then 12-24h. after starting tablets, taper IV infsn over

5days. Reduce dose of digoxin and warfarin. Pulseless VF or VT; 5mg/kg IV. o Amisulpride . Negative: 1-6mg/kg 9adult 50-300mg) daily oral. Mixed - pos: 4- 12mg/kg/dose (adult 200-600mg) daily. o Amitriptyline hydroclhoride . Usuaaly 0.5-1mg/kg/dose (adult 25-50mg) 8H oral. Eneuresis: 1-1.5mg/kg nocte. o Amlodipine . 0.05-0.2mg/kg (adult 2.5-10mg)daily oral. o Amomarbital . See amylobarbitone. o Amodiquine . Treatment: 10mg/kg daily for 3 days oral. Prophylaxys: 5mg/kg once awk. o Amorolfine . Nail lacquer 5%: apply x 1-2/wk. o Amoxapine . 0.5-2mg/kg/dose (adult 25-100mg) 8H oral. o Amoxycillin . see amoxycillin. o Amoxycillin . 10-25mg/kg/dose (adult 0.25-1g) 8H IV, IM or oral; or 20mg/kg/dose 12H oral. Severe inftn: 50mg/kg/dose (adult 2g) IV 12H (1st wk life). 6H (2-4wk), 4-6H or constant infsn (4 +

wk). o Amoxycillin and clavulanic acid. Dose as for amoxycillin. 4:1 (non - Duo products) given 8H. 7:1 (Duo) 12H oral. o Amphetamine . see dexamphetamine. o Amphotericin B . 0.5-1.5mg/kg/day by continous infusion IV; total dose 30-35mg/kg over 4-8 wk. Oral (NOT/kg); 100mg 6H treatment, 50mg 6H prophylaxis. Bladder Washout; 25mcg/ml.

cream or oinment 3%; apply 6-12H. o Amphotericin, lipid complex or liposomal . 2-3mg/kg daily over 1hr IV. Total do0se typically 20-60mg/kg over 2-4 wk. o Ampicillin . 10-25mg/kg/dose (adult 0.25-1g) 6H IV, IM or oral. Severe inftn; 50mg/kg/dose (max 2g) IV 12H (1 st wk life), 6H (2-4 wk), 3-6H or constant infsn (4+wk). o Amprenavir . soltn; 22.5mg/kg/dose 12H, or 17mg/kg/dose 8H (max 2.8g/day) oral. Capsules: 20mg/kg/dose (adult1-2g) of ampicillin 6H or IV over 30 min. o Amrinone . <4wk old; 4mg/kg IV over 1hr, then 3-5mcg/kg/min. >4wk: 1-3mg/kg IV over 1hr, then 5-15mcg/kg/min.

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o Amsacrine . 450-600mg/m2 IV over2hr daily for 3-5 days. o Amylase . See pancreatic enzymes. o Amylobarbitone . 0.3-1mg/kg/dose (adult 15-50mg) 8-12H, or 2-4mg/kg (adult 200- 400mg) at night, oral. o Anagrelide hydroclhoride . Adult (NOT/kg): 1mg/dose 12h, incr slowly if reqd to max 2.5mg/dose 6H oral. o Anakinra . Adult (NOT/kg): 100mg daily SC. o Anastrozole . Adul;t (NOT/kg): 1mg daily oral. o Ancestim (human stem cell factor). 20mcg/kg/day SC . o Aneurine . See thiamine. o Anistreplase . Adult (NOT/kg): 30u IV over 5min. o Anthraquinone . See sennoside. o Antihaemophillic factor . See factor 8 . o Anti-inhibitor coagulant complex . See factor 8 inhibitor bypassing fraction. o Antilymphocyte globulin . See immunoglobin, antilym'te. o Antivenom to Australian box jellyfish, snakes (black, brown, death adder, sea,taipan, tiger), spiders ( fun-nel-web) and ticks . Dose deppends on amount of venom injected, not size of patient.

Higher doses needed for multiple bites, severe symptoms or delayed administration. Give adrenalline 0.005g/kg (0.005ml/kg of 1 in 1000) SC. Initial dose antivenom usually 1-2 amp diluted 1/10 in Hartmann's soltn IV over 30min. Monitor PT, PTT, fibrinogen, platelets. Give repeatedly if symptoms or coagulopathy persist.

o Antivenom to black widow spider (USA), red back spider (Australia) . 1amp IM, may repeat in 2hr. severe envenomation: 2amp diluted 1/10 in Hartmann's soltn IV over 30min. o Antivenom to coral snake (USA) . 3-6 vials IV over 1-2hr, repeat if signs progress. Premidicate with diphenhydramine 5mg/kg (adult 300mg) IV, have adrenalline available. o Antivenom to Crotalidae ( plt vipers, rattlesnakes - USA) . 4-6 vials, with hidher dose for more severe envenomation, diluted 1/10 in saline IV over 1hr, repeated 1hr later if reqd; then 2 vials

6H for 3 doses. o Antivenom, stonefish . 1000u (2ml) per puncture IM. Severe envenomation: 1000u/ puncture diluted 1/10 in Hartmann's soltn IV over 30min. o Apomorphine hydrochloride . adult (NOT/kg): usually 2.4-3.6mg/dose (max6mg) prn to max 50mg/day SC. Infsn: 0.02-0.08mg/kg/hr (max 200mg/day) SC. o Apraclonidine hydrochloride . 1-2drops/eye 8H (0.5%), 12H (1%). o Aprostadil . See alprostadil. o Aprotinin (1kiu = 140ng = 0.00056epu, 1mg = 7143kiu) . 1.200,000 kiu/m2 IV over 1hr (plus 1,200,000 kiu/m2 in prime), then 300,000 kiu/m2/hr; half for "low dose". Adult (NOT/kg): 2,000,000

kiu Ivover 1hr (plus 2,000,000 kiu in prime), then 500,000 kiu/hr; half for "low dose". Prophylaxis; 4000 kiu/kg, then 2000kiu/kg/dose 6H IV. o Argratoban . 2mcg/kg/min; adjust to maintain APTT x 1.5-3. o Arginine hydroclhoride . Dose (mg) = BE x Wt (kg) x 70 (give half this)IV over 2hr. o Artemether, oily soltn . 3.2mg/kg IM stat, then 1.6mg/kg daily until oral therapy possible. o Artemisinin . 25mg/kg oral day; then 12.5mg/kg daily for 2 days (with mefloquine 15-25mg/kg on day 2), or for 4-6 days if mefloquine resistance. o Artesunate . Oral: 5mg/kg day 1; then 2.5mg/kg daily for 2 days (with mefloquine 15-25mg/kg on day 2), or for 4-6 days if mefloquine resistance. IM or IV over 1-2min: 2mg /kg stat, then

1mg/kg in 6hr if hyperparasitic, then 1mg/kg daily until oral theraphy possible. o Ascorbid acid . Burn (NOT/kg): 200-500mg daily IV, IM, SC, oral. Metabolic dis (NOT/kg):250mg (<7yr) 500mg (>7yr) daily oral. Scurvy (NOT/kg): 100mg/dose 8H oral for 10 days. Urine

acidification: 10-30mg/kg/dose 6H. o Asparaginase . See colaspase. o Aspirin . 10-15mg/kg/dose (adult 300-600mg) 4-6H oral. o Antiplatelet : 3-5mg/kg (max 100mg) daily. Kawasaki: 10mg/kg/dose 6H (low dose) or 25mg/kg/dose 6H (high dose) for 2wk, then 3-5mg/kg daily. Arthritis: 25mg/kg/dose (max 2g) 6H for 3

days, then 15-20mg/kg/dose 6H. Salicylate level (arthritis)midway between doses 0.7-2.0mmol/L (x 13.81 = mg/100ml). o Aspirin . 25mg + diprydamole 200mg. adult (NOT/kg): 1 sustained rel cap 12H oral. o Astemizole . 0.2mg/kg (adult 10mg) daily oral.

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o Atenolol . Oral; 1-2mg/kg/dose (adult 50-100mg) 12-24H. IV; 0.05mg/kg (adult 2.5mg) every 5min until response (max 4 doses), then 0.1-0.2mg/kg/dose (adult 5-10mg)over 10min 12-24H. o Atorvastatin . 0.2mg/kg (adult 10mg) daily, incr if reqd every 4wk to max 1.6mg/kg (adult 80mg) daily. o Atovaquone 250mg and proguanil 100mg (Malarone) . Treatment; 20mg/kg of atovaquone (adult 1g) daily for 3 consecutive days oral. Prophylaxys; 5mg/kg of atovaquone(adult 250mg) daily. o Atovaquone 62.5mg and proguanil 25mg (Malarone paediatric). Prophilaxys; 5mg/kg(adult 250mg) daily oral. o Atracurium besylate . 0.3-0.6mg/kg stat, then 0.1-0.2mg/kg when reqd or 5 - 10mcg/kg/min IV. o Atropine sulphate . 0.02mg/kg (max 0.6mg) IV or IM, then 0.01mg/kg/dose 4-6H. Or ganophosphate poisoning; 0.05mg/kg (adult 2mg) IV, then 0.02-0.05mg/kg/dose (adult 2mg) every 15-60

min until atropinised (continue 12-24hr). Colic: See phenobarbitone. o Attapulgite . Adult (NOT/kg): 0.6-1.2g/dose 3-6H oral. o Auranofin . 0.1mg/kg (adult 6mg) daily oral, incr if reqd to max 0.05mg/kg/dose (adult 3mg) 8H. o Aurothioglucose . 0.25mg/kg wekkly IM, incr to 1mg/kg (max 40mg) weekly for 20wk, then every 1-4wk. o Azapropazone . 10mg/kg/dose (max 600mg) 12H oral. Acute gout: 6H (day 1), 8H (day 2), then 12H. o Azatadine . NOT/kg: 0.5-1mg/dose (child >6yr), 1-2mg (adult) 12-24H oral. o Azathioprine . 25-75mg/m2 (approx 1-3mg/kg) daily oral, IV. o Azelaic acid . Micronised 20% cream: apply 12H. o Azelastine . 0.1% spray, >5yr: 0.15ml to aech nostril 12H. o Azidothymidine . (AZT), See Zidovudine. o Azithromycin . 15mg/kg (adult 500mg) day 1, then 7.5mg/kg (adult 250mg) day 2-5 oral. Trachoma: 20mh/kg (adult 1g) wkly x3. MAC prophilaxys (adult): 1.2wkly. Gp A strep: 20mg/kgh daily

x3. o Aztreonam . 30mg/kg/dose (adult 1g) 8H IV. Severe inftn: 50mg/kg/dose (adult 2g) 12H (1 st wk life), 8H (2-4 wk), 6H or constant infsn (4 + wk).

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o Bacampicillin . 15-25mg/kg/dose (adult 400-800mg) 12H oral. o Bacillus Calmatte - Guerin (BCG) Vaccine (CSL). Live Intradermal . (1mg/ml):0.075ml ( <3mo) or 0.1ml (>3m0) once. Percutaneous (60mg/ml suspension):1 drop on skin, inoculated with Heaf

apparatus, once. o Bacillus Calmatte - Guerin (BCG) suspension, about 5 x 10^8 cfu/vial . Adult: 1vial (Onco TICE) or 3 vials (Immu - Cyst) left in bladder for 2hr each wk for 6wks, then at 3.6,12,18 and 24mo. o Bacitracin 400u/g + neomicyn 5mg/g + polymiyxin B 5000u/g (Neosporin) . Ointment or eye ointment: apply x2-5/day. Powder: apply 6-12H (skin inftn), every few days (burns). Eye drops: see

gramicidin . o Baclofen . 0.2mg/kg/dose (adult 5g) 8H oral, incr every 3 days to 1mg/kg/dose (adult 25mg, max 50mg) 8H, Intrathecal infsn: 2-20mcg/kg (max 1000mcg) per 24hr. o Balsalaside . Adult (NOT/kg): 2.25g 8H oral (= 2,34g mesalazine daily). o Bambuterol . 0.2-0.4mg/kg (adult 10-20mg) nocte oral. o Basiliximab . 12mg/m2 (max 20mg) IV 2hr preop, repeated 4 days later. o BCG Vaccine . See Bacillus Calmatte - Guerin vaccine. o Beclomethasone dipropionate . Rotacap or aerosol (NOT/kg): 100-200mcg (<8yr),150-400mcg (>8yr), x2/day (rarely x4/day). Nasal (NOT/kg): aerosol or pump (50mcg/spray): 1spray 12H

(<12yr), 2spray 12H (>12yr). o Benazepryl . 0.2-0.4mg/kg.dose (adult 10-20mg) 12-24H oral. o Bendruflumathiazide . See levodopa and benserazide. o Bendrofluazide .0.1-0.2mg/kg (adult 5-10mg) daily oral. o Benorylate .30mg/kg/dose (adult 1.5g) 8H oral. o Benperidol .5-15mcg/kg/dose (adult 0.25-1.5mg) 12-24H oral.

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o Benserazide . See levodopa and benserazide . o Benzathine penicillin . See penicillin, benzathine . o Benzbromarone . Adult (NOT/kg): 50-300mg daily oral, or 20-25mg/dose with allopurinol . o Benzhexol . >3yr: 0.02mg/kg/dose (adult 1mg) 8H, incr to 0.1-0.3mg/kg/dose with allopurinol. o Benzocaine . 1%-20% topical: usually applied 4-6H. o Benzoic acid 6% + salicylic acid 3% .Whitfield's ointment apply 12H. o Benzonatate . 2-4mg/kd/dose (adult 100-200mg) 8H oral . o Benzoyl peroxide . Liquid, gel 2.5%-10%: apply x1-3/day. o Benzquinamide . IM: 0.5-1mg/kg (adult 50mg) stat ang repeat in 1hr if needed, then 3-4H prn. IV over 1-5min: 0.2-0.4mg/kg (adult 25mg) once. o Benzythiazide 25mg + triamterene 50mg . Adult (NOT/kg): 1-2 tab on alternate days, oral . o Benztropine . >3yr: 0.02mg/kg (adult 1mg)stat IM or IV, may repeat in 15min. 0.02-0.06mg/kg/dose (adult 1-3mg): 2-24H oral . o Benzyl benzoate . 25% lotion. Scabies: apply from neck down after a hot bath, remove in bath after 24hr; repeat after 5 days. Lice: apply to infected region, wash affafter 24hr; repeat after 7

days. o Benzylpenicillin . See penicillin G . o Bepridil . 4-8mg/kg (adult 200-400mg) daily oral . o Beractant (bovine surfactant, survanta). 25mg/ml soltn. 4ml/kg intratracheal 2-4 doses in 48hr, each dose in 4 parts: body inclined down with to right, body down head left, body up head

right, body up head left . o Beta carotene . Porphyria: 1-5mg/kg (adult 30-300mg daily oral . o Betahistine dihydroclhoride . 0.15-0.3mg/kg/dose (adult 8-16mg) 8H oral. o Betaine hydroclhoride .Usually 60mg/kg/dose (adult 3g) 12H oral, max 100mg/kg/dose (adult 5g) 12H. o Betamethasone acetate 3mg/ml with betamethasone sodium phospate 3.9mg/ml (Celestone Chronodose). Adult: 0.25-2ml (NOT/kg) intramuscular, intra- articular, or intralesional injection . o Betamethasone .0.01-0.2mg/kg daily oral. Betamethasone has no mineralocorticoid action, 1mg = 25mg hydrocortisone in glucocortiroid action, Gel 0.05%; cream, lotion or ointment, 0.02%,

0.05%, 0.1%: apply sparingly 8-24H. o Betaxolol . 0.4-0.8mg/kg (adult 20-40mg) daily oral. Eya drops 0.25%-0.5%. 1-2 drops per eye 12H. o Bethanecol . Oral: 0.2-1mg/kg/dose (adult 10-50mg) 6-8H. SC: 0.05-0.1mg/kg/dose (adult 2.5-5mg) 6-8H. o Bexarotene . Usually 300mg/m2 (range 100-400mg/m2) daily oral. o Bezafribate . 4mg/kg/dose (adult 200mg) 8H oral with food. o Bicalutamide . Adult (NOT/kg): 50mg daily oral. o Bicarbonate Slow IV : dose (mmol) = BE x Wt/4 (<5kg), BE x Wt/6 (child), BE x Wt/10 (adult). These doses corect half the base deficit. Alkalinise urine: 0.25mmol/kg 6-12H oral. o Bifonazole . 1% cream: apply daily for 2-4wk. o Bimatropost . 0.03% drops: 1 drop/eye each evenig . o Biotin ( coenzyme R, vitamin H ).NOT/kg: 5-20mg daily IV, IM SC or oral. o Biperiden hydroclhoride . 0.02-0.04mg/kg/dose (adult 1-2mg) 8-12H oral. IM or slow IV: 0.05-0.1mg/kg (adult 2.5-5mg), max x4/day. o Bisacodyl . NOT/kg: <12mo 2.5mg PR, 1-5yr 5mg PR or 5-10mg oral, >5yr 10mg PR or 10-20mg oral. Enema: half daily (6mo-3yr), 1 enema daily (>3yr). o Bismuth subcitrate ( colloidal ). 5mg/kg/dose (adult 240mg) 12H oral 30min before meal. H. pylori (adult,NOT/kg): 107.7mg/dose x 4/day with meals and nocte for 2wk + tetracyline

500mg/dose x4/day + metronidazole 200mg with meals and 400mg nocte: see alson omeprazole. o Bismuth subsalicylate . See bismuth subcitrate. o Bisoprolol . 0.2-0.4mg/kg (adult 10-20mg) daily oral. o Bitolterol . Resp soltn (0.2%): 1ml/dose diluted to 4ml 3-6H (mild), 2ml/sdose diltd to 4ml 1-2H (moderate), undiltd constant (severe, in ICU). Aerosol 370mcg/puff: 1-2 puff 4-6H. o Bivalirudin . 0.75-1mg/kg IV stat, then 1.75-2.5mg/kg/hr for 4hr, then stop or give 1.75-2mg/kg/hr for 14-20hr.

7

o Bleomycin sulfate . 10-20u/m2 IM, SC or IV over 15min x 1-2/wk. Max total dose 250u/m2. o Blood . 4ml/kg packed cells raises Hb 1g%. 1 bag = 300ml . o Bosentan . 1mg/kg/dose (adult 62.5mg) 12H oral for 1-4 wk, then 2mg/kg/dose (adult 125mg) 12H. IV: half oral dose. o Botulinum toxin type A . NOT/kg: 1.25-2.5u/site (max 5u/site) IM, max total 200u in 30 days. Oesoph achalasia: 100u per sesion divided between 4-6 sites. o Botulinum toxin type B .NOT/kg: usual total dose 2,500-10,000u repeated every 3-4mo if reqd . o Bowel washout . See colonic lavage soltn . o Bretylium tosylate . 5-10mg/kg IV over 1hr, then 5-30mcg/kg/min. o Brimonidine tartrate . 0.2%: 1 drop/eye 12H. o Brinzolamide . 1%: 1 drop/eye 8-12H. o Bromazepam . 0.02-0.1mg/kg/dose (adult 1-3mg) 8h oral. o Bromhexine . 0.3mg/kg/dose (adult 16mg) 8H oral for 7 daya, then 0,15mg/kg/dose (adult 8mg) 8H. o Bromocriptine mesylate . 0.025mg/kg/dose (adult 1.25mg) 8-12H, incr wkly to 0.05- 0.2mg/kg/dose (adult 2.5-10mg) 6-12H oral. Inhibit lactn, NOT/kg: 2.5mg/dose 12H for 2wk. o Brompheniramine . 0.1-0.2mg/kg/dose (adult 5-10mg) 6-8H oral, SC, IM, or slow IV, o Buclizine . 0.25-1mg/kg/dose (adult 12.5-50mg) 8-24H oral . o Budesonide . Metered dose inhaler (NOT/kg):<12yr 50-200mcg 6-12H, reducing to 100-200mcg 12H;> 12yr 100-600mcg 6-12H, reducing to 100-400mcg 12H. Nebuliser(NOT/kg):<12yr 0.5-

1mg 12H, reducing to 0.25-0.5mg 12H;> 12yr 1-2mg 12H, reducing to 0.5-1mg 12H. Croup: 2mg (NOT/kg) by nebuliser. Nasal spray or aerosol (NOT/kg): 64-128mcg/nostril 12-24H. Crohns dis, adult (NOT/kg): 9mg daily for 8wk, then reduce over 5wk.

o Bumetanide . 25mcg/kg (adult 1mg) daily oral, may incr to max 50mcg/kg (adult 3mg) 8-12H . o Bupivacaine . Max dose: 2-3mg/kg (0.4-0.6ml/kg of 0.5%). With adrenaline: max dose: 3-4mg/kg (0.6-0.8ml/kg of 0.5%). Epidural: 2mg/kg (0.4ml/kg 0.55) stat intraop, then 0.25mg/kg/hr

(0.2ml/kg/hr 0.125%) postop. Epidural in ICU: 25ml 0.5% + 1000mcg (20ml) fentanyl + saline to 100ml at 2-8ml/hr in adult. o Buprenophine . 3-12mcg/kg/dose (adult 200-600mcg) 6-8H sublingual, IM or slow IV. o Bupropion . 2-3mg/kg/dose (adult 100-150mg) 8-12H oral. o Burrow's solution . See aluminium acetate soltn . o Buserelin (gonaderelin analogue) . Adult. Intranasal: 100mcg/dose (NOT/kg) 4H, or 150mcg (NOT/kg) each nostril 8H. SC: 0.5mg/dose (NOT/kg) 8H. o Buspirone . 0.1mg/kg/dose (adult 5mg) 8-12H oral, incr to max 0.3mg/kg/dose (adult 15mg) 8-12H . o Busulfan . Induction: 0.06mg/kg (max 4mg) daily oral if leucocytes > 20,000/mm3 and platelets > 100,000/mm3, Maintenance: 0.01-0.03mg/kg (max 2mg) daily. o Butabarbital . See secburtobarbitone . o Butalbital . 1-2mg/kg/dose (adult 100-200mg) nocte oral. o Butoconazole nitrate . 2% vaginal cream: 5g (NOT/kg) nocte for 3-6 days. o Butorphanol . IM: 0.02-0.1mg/kg/dose (adult 1-4mg) 3-4H IV: 0.01-0.05mg/kg (adult 0.5-2mg) 3-4H.

C o C 1 esterase inhibitor, 1u= activity 1ml plasma. 10-50u/kg IV over 1hr once (prophylaxis), 12-24H (treatment) . o Cabergoline . 10mcg/kg/wk (adult 05mg) in 1-2 doses, incr if reqd monthly by 10mcg/kg/wk to usually 20mcg/kg/wk (adult 1mg) in 1-4 doses, max 90mcg/kg/wk (adult 4.5mg). o Caffeine citrate . 2mg citrate = 1mg base. 1-5mg/kg/dose (adult 50-250mg) of citrate, 4-8H oral,PR, Neonate: 20mg/kg stat of citrate, then 5mg/kg daily oral or IV over 30min; weekly level 5-

30mg/L midway between doses. o Calamine . Lotion: usually applied 6-8H. o Calcifediol (25-OH D3) . Deficiency: 1-2mcg/kg daily oral . o Calciferol (ergocalciferol) . See vitamin D2. o Calcipotriene . 0.0055 ointment: apply 12H.

8

o Calcipotriol . 50mcg/g ointment: apply 12-24H. o Calcitonin . Hypercalcaemia: 4u/kg/dose 12-24 H IM or SC, may incr up to 8u/kg/dose 6-12H. Paget's: 1.5-3u/kg (max 160u) x3/wk IM or SC. o Calcitriol (1,25-OH vitamin D3) . Renal vailure, vit D resistant rickets: 0.02mcg/kg daily oral, incr by 0.02mcg/kg every 4-8wk according to serum calcium. o Calcium (as carbonate, lactate or phosphate) . NOT/kg: Neonata: 50mg x4-6/day; 1mo-3yr: 100mg x2-5/day oral; 4-12yr: 300mg x2-3/day; >12yr: 1000mg x1-2/day. o Calcium carmibide . 1-2mg/kg/dose (adult 50-100mg) 12H oral . o Calcium carbonate . Adult NOT/kg: 840mg 8-12H oral. o Calcium Chloride . 10% soltn (0.7mmol/ml Ca): 0.2ml/kg (max 10ml) slow IV stat. Requirement <16yr 2ml/kg/day IV. Inotrope: 0.5-2mmol/kg/day (0.03-0.12ml/kg/hr). o Calcium edatate (EDTA). See sodium calciumedatate. o Calcium folinate . NOT/kg: 5-15mg oral, or 1mg IM or IV daily. Rescue starting up to 24hr after methotrexate: 10-15mg/m2/dose 6H for 36-48hr IV. Methotrexate toxicity: 100-

1000mg/m2/dose 6H IV. Before a fluorouracil dose of 370mg/m2: 200mg/m2 IV daily x5, repeat every 3-4wk. o Calcium gluconate .10% soltn (0.22mmol/ml Ca): 0.5ml/kg (max 20ml) slow IV stat, Requirement <16yr 5ml/kg/day IV. Inotrope: 0.5-2mmol/kg/day (0.1-0.4ml/kg/hr). o Calcium polystyrene sulfonate (Calcium Resonium).0.3-0.6g/kg/dose (adult 15-30g) 6H NG ( +lactulose), PR. o Calfactant . 35mg/ml phosphlipids, 0.65mg/ml proteins: 1.5ml/kg intratracheal gradually over 20-30 breaths during inspirations with infant lying on one side, then another 1.5ml/kg with infant

lying on other side. o Candesartan cllexetil . 0.1-0.3mg/kg (adult 4-16mg) daily oral. o Canrenoate potassium . 3-8mg/kg (adult 150-400mg) daily IV. o Capecitabine . 1250mg/m2/dose 12H oral for 2wk then 1wk off, in 3wk cycles. o Capreomicyn sulphate . 20mg/kg (adult 1g) IM daily, decr after 2-4mo to 2-3 timesper wk. o Capsaicin . Cream 0.025%, 0.075%. apply 6-8H. o Captropil . Beware hypotension. 0.1mg/kg/dose (adult 50mg) 8H oral, incr if reqd to max 2mg/kg/dose (adult 50mg). o Carbachol . 0.01%: max 0.5ml in anterior chamber of eye. o Carbamazepine .2mg/kg/dose (adult 100mg) 8H oral, may incr over 2-4wk to 5-10mg/kg/dose (adult 250-500mg) 8H. Level 20-40 umol/L (x0.24=mg/l), done Mo-Fri 1100 RCH. o Carbenicillin . 382mg tab, adult (NOT/kg): 1-2 tab 4H oral. o Carbenoxolone sodium . Adult (NOT/kg): 20-50mg 6H oral. Mouth gel 2%, or 2g granules in 40ml in water, apply 6H . o Carbidopa . See levodopa and carbidopa. o Carbimazole . 0.4mg/kg/dose (adult 20mg) 8-12H oral for 2wk, then 0.1mg/kg/dose (adult 5-10mg) 8-24H. o Carbinoxamine . NOT/kg: 2mg (1-3yr), 2-4mg (3-6yr), 4-8mg (>6yr) 6-8H oral. o Carbocisteine .10-15mg/kg/dose (adult 500-750mg) 8H oral. o Carboplatin . 300-400mg/m22 IV over 60min every 4wk. o Carboprost (15-Me-PGF2-alpha). Termination (NOT/kg): 250-500mcg/dose 1-4H (max totl 12mg)IM.Postpart hge(NOT/kg):250mcg every15-120min IM(max total12mg) o Carisoprodol . 7mg/kg/dose (adult 350mg) 6H oral. o Carmustine (BCNU). 200mg/m2 IV over 2hr every 6wk (reduce if leucocytes <3000/mm3 or platelets <75,000). o Carnitine, L form . IV: 5-15mg/kg/dose (max 1g) 6H, oral; 25mg/kg/dose 6-12H (max 3g/day). o Carob bean gum (Carobel Instant) . NOT/kg: 1 scoop (1,8g) in 100ml water, give 10- 20ml by spoon; or add half a scoop to every 100-200ml of milk. o Carteolol . 0,05-0.2mg/kg (adult 2.5-10mg) daily oral. o Carvedilol . 0.08mg/kg/dose (adult 3.125mg) every 1-2wk to max 0.5-0.75mg/kg/dose (adult 25mg) 12H. o Casanthranol + docusate sodium . Cap 30mg/100mg (NOT/kg): adult 1-2cap 12- 24H oral. Syrup 2mg/4mg per ml (NOT/kg): child 5-15ml bedtime, adult 15-30ml 12-24H. o Caspofungin . Adult (NOT/kg): 70mg day 1, then 50mg (up to 70mg) daily IV over 1hr. o Ceflacor monohydrate . 10-15mg/kg/dose (adult 250-500mg) 8H oral. Slow release tab 375mg (adult, NOT/kg): 1-2 tab 12H oral. o Cefadroxll . 15-25mg/kg/dose (adult 0.5-1g) 12H oral.

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o Cefamandole . See cephamandole . o Cefazollin . See cephazolin. o Cefdinir . 14mg/kg (adult 600mg) daily (or in two divided doses) oral. o Cefditoren . 4-8mg/kg/dose (adult 200-400mg) 12-24H oral. o cefepime hydrochloride . 25mg/kg/dose (adult 1g) 12H IM or IV over 5min. Severe inftn: 50mg/kg/dose (adult 2g) IV 8-12H or constant infsn. o Ceflxlme . 5mg/lg/dose (adult 200mg) 12-24H oral. o Cefodizime . 25mg/kg/dose (max1g) 12H IV or IM . o Cefonicid . 15-50mg/kg (adult 0.5-2g0 Ivor IM daily. o Cefoporazone . 25-60mg/kg/dose (adult 1-3g) 6-12H IV over 1hr or IM. o Cefotaxime . 25mg/kg/dose (adult 1g) 12H (<4wk), 8H (4+wk) IV, severe inftn; 50mg/kg/dose (adult 2-3g) IV 12H (preterm), 8H (1 st wk life), 6H (2-4wk), 4-6h or constant infsn (4+wk). o Cefotetan . 25mg/kg/dose (adult 1g) 12H IM, IV Severe inftn: 50mg/kg/dose (max 2- 3g) 12H or constant infsn. o Cefoxitin .25-60mg/kg/dose (adult 1-3g) 12H (1 st wk life), 8H (1-4wk), 6-8H (>4wk) IV o Cefpirome . 25-50mg/kg/dose (adult 1-2g) 12H IV. o Cefpodoxime . 5mg/kg/dose (adult 100-200mg) 12H oral. o Cefprozil . 15mg/kg/dose (adult 500mg) 12-24H oral. o Ceftazidime . 15-25mg/kg/dose (adult 0.5-1g) 8H (1 st wk life), 8H (2-4wk), 6H or constant infsn (4+ wk). o Ceftibuten . 10mg/lg (adult 400mg) daily oral. o Ceftizoxime . 26-60mg/kg/dose (adult 1-3g) 6-8H IV. o Ceftrlaxone sodium . 25mg/kg/dose (adult 1g) 12-24H IV, or IM (in 1% lignocaine). Severe inftn: 50mg/kg/dose (max 2g) daily (1 st wk life), 12H (2+wk). Epiglotitis: 100mg/kg (max 2g) stat,

then 50mg/kg (max 2g0 after 24hr. Meningococcus prophylaxis (NOT/kg): child 125mg, >12yr 250mg IM in 1% lignocaine once. o Cefuroxime . Oral: 10-15mg/kg/dose (adult 250-500mg) 12H. IV: 25mg/kg/dose (adult 1g) 8H. Severe inftn: 50mg/kg/dose (max 2g) IV 12H (1 st wk life), 8H (2nd wk), 6H or constant infsn

(>2wk). o Celecoxib . Usually 2mg/kg./dose (adult 100mg) 12H, max 4mg/kg/dose (adult 200mg) 12H oral. o Celiprolol . 5-10mg/kg (adult 200-400mg) daily oral. o Cephalixyn . 7.5mg/kg/dose (adult 250mg) 6H, or 15mg/kg/dose (adult 500mg) 12H oral. o Cephalothin . 15-25mg/kg/dose (adult 0.5-1g) 6H IV or IM, Severe inftn: 50mg/kg/dose (max 2g) IV 4H or constant infsn. Irrigation fluid: 2g/L (2mg/ml). o Cephamandole . 15-25mg/kg/dose (adult 0.5-1g0 6-8H IV over 10min or IM. Severe inftn: 40mg/kg/dose (adult 2g) IV over 20min 4-6H or constant infsn. o Cephazolin . 1-15mg/kg/dose (adult 0.5g) 6H IV or IM. Severe inftn: 50mg/kg/dose (adult 2G0 IV 4-6H or constant infsn. Surgical proph: 50mg/kg IV at induction. o Ceprhadine . Oral: 10-25mg/kg/dose (adult 0.25-1g) 6H IM or IV: 25-50mg/kg/dose (adult 1-3g) 6H. o Certoparin . Prophylaxis : 60u/kg (adult 3000u) 1-2hr preop, then daily SC. o Cerumol . See dichlorobenzene + chlorbutol otic. o Cetirizene . 0.25mg/kg/dose (adult 10mg0 12-24H oral. o Cetrorelix . (GnRH antagonist). Adult (NOT/kg): 0.25mg SC on stimulation day 5, then daily until hCG given. o Cetylpyridium + benzocaine . Mouth wash (Cepacaine): apply 3H pm. Do not swallow. o Cevimeline. 0.6mg/kg/dose (adult 30mg) 8H oral. o Charcoal, activated. Check bowel sound present. 1-2g/kg (adult 50-100g) NG; then if reqd 0.25g/kg hourly NG. Laxative: sorbitol 1g/kg (1.4ml/kg of 70%) once Ng, may repeat once. o Chenodeoxycholic acid . 5-10mg/kg/dose 12H oral. o Chickenpox vaccine . See varicella vaccine. o Chloral betaine . 1.7mg =1mg chloral hydrate.

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o Chloramphenicol. Severe inftn: 40mg/kg (max 2g) stat, then 25mg/kg.dose (max 1g) IV,IM or oral . 1 st wk life daily; 2-4wk 12H; >4wk 8H for 5 days, then 6H. Eye drops, oint:apply 2-6H. Ear: 4 drops 6H. Serum level 20-30mg/L at 2hr, <15mg/L trough.

o Chlorambucil. Typically 0.1-0.2mg/kg/daily oral. o Chloral hydrate . Hypnoyic: 50mg/kg (max 2g) stat 9up to 100mg/kg, max 5g, in ICU).Sedative: 8mg/kg/dose 6-8H oral or PR. o Chlordiazepoxide . 0.1mg/kg/dose (adult 5mg) 12H oral, may incr to max 0.5mg/kg/dose (adult 30mg) 6-8H. o Chlorhexidine . 0.1% ; catheterisation prep, impetigo. 0.2%; mouthwash. 1%; skin disinfection. 2-4%: hand wash. o Chlorhexidine 0.5% + alcohol 70%. Skin desinfection. o Chlorhexidine 1,5% + cetrimide 15%. 1/30 in water: cleaning tissue or wounds, equipment before sterilitation. 140ml in 1L water: desinfecting skin, equipment ( soak 2min, rinse in steril

water) o Chlorhexidine + cetrimide . 0.05%/0.55, 0.1%/1%, 0.15%/0.15% soltn: wound cleaning. o Chlorhexidine 1% + hexamidine 0.15%. Powder: wound cleaning. o Chlormethlozole . IV (edysilate 0.8%): 1-2ml/kg (8-16mg/kg) over 15min, then0.5-1ml/kg/hr (4-8mg/kg/hr). Capsule 192mg base, adult (NOT/kg): 2-4cap stat (may repeat in 1-2hr), then 1-2cap

8H, oral. o Chlormezasone . 5mg/kg/dose (adult 200mg) 6-8H, or 10mg/kg (adult 400mg) at night oral. o Chlorophyllin copper complex . 2mg/kg/dose 8-24H oral. o Chloroprocaine . Max 11mg/kg (max 800mg). With adrenaline (1/200,000) max 14mg/kg (max 1000mg). o Chloroquine, base . Oral 10mg/kg (max600mg) daily x3 days. IM: 4mg/kg/dose (max 300mg) 12H for 3 days. Prophylaxis: 5mg/kg (adult 300mg0 oral x1/wk. Lupus, rheu arthritis: 12mg/kg

(max 600mg) daily, reduce to 4-8mg/kg (max 400mg) daily oral. o Chlorotiazide . 5-20mg/kg/dose (adult 0.25-1g) 12-24H oral, IV. o Chloroxylenol . 0.3% cream, 2.5-5% liquid: to clean skin or wounds. o Chlorphenasin. 1% ointment: apply 12H. o Chlorpheniramine maleate . 0.1mg/kg/dose (adult 4mg) 6-8H oral. o Chlorpheniramine maleate 1.25mg + phenylephrine . 2.5mg in 5ml. Syrup (NOT/kg): 1.25-2.5ml (0-1yr), 2.5-5ml (2-5yr), 5-10ml (6-12yr), 10-15ml (>12yr) 6-8H oral. o Chlorpormazine . Oral or PR: 0.5-2mg/kg/dose ( max 100mg) 6-8H; up to 20mg/kg/dose 8H for psychosis. IM (painful)or slow IV (beware hypotension): 0.25- 1mg/kg/dose (usual max 50mg)

6-8H. o Chlorpropamide . Adult: initially 125-250mg(NOT/kg): daily oral, max500mg daily. o Chlorquinaidol . 5% paste: apply 12H. o Chlortetracylline . 3% cream or ointment: aplly 8-24H. o Chlortalidone . 2mg/kg (max 100mg) 3 times a wk oral. o Chlorzoxzone . 5-15mg/kg/dose (adult 250-750mg) 6-8H oral. o Cholecalciferol . See vitamin D3. o Cholera vaccine, parenteral (CSL). Inactivated. 2doses SC 7-28 days apart: 0.1ml then 0.3ml (<5yr), 0.3ml then 0.5ml(5-9yr), 0.5ml then 1ml (>9yr). Boost every 6mo (use 1 st dose). o Cholera vaccine, oral (Orochol). Live. >2yr: 1sachet + 100ml water. Boost every 6mo. o Cholestyramine . NOT/kg: 1g/dose (<6yr) 2-4g/dose (6-12yr) 4g/dose(>12yr) 4-12H oral with feeds. 16% paste: apply 8-12H. o Choline magnesium trisalicylate . See aspirin. o Choline salicylate, mouth gel (Bonjela). Apply 3H pm. o Choline theophyllinate (200mg = theophylline 127mg) . See theophyline. o Chorlonic gonadotrophin . Cryptorchidism all ages (NOT/kg): 500-1000u x1-2/ wk for 5wk. After FSH: 10,000iu (NOT/kg): IM once. Man 7000iu (NOT/kg) IM x2/wk, with 75iu FSH and 75iu LH

IM x3/wk. o Chymopapain . Adult: 2000-4000 picokatal units per disc (NOT/kg), max 10000 picokatal units per patient.

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o Ciclopirox . 1% crteam or lotion: apply 2H o Cidofovir . 5mg/kg over 1hr IV on day 0, day 7, then every 14 days (given with probenecid). o Cllastatin . See imipenem. o Cllazapril . Usually 0.02-0.1mg/kg (adult 1-5mg) daily oral. Renal hypertension: 0.005- 0.01mg/kg/daily oral. o Cllostazol . Adult (NOT/kg): 100mg/dose 12H oral. o Cimetidine . Oral: 5-10mg/kg/dose (adult 300-400mg) 6H, or 20mg/kg (adult 800mg) nocte. IV: 10-15mg/kg/dose (adult 200mg) 12H (newborn), 6H (>4wk). o Cinnarizine . 0.3-0.6mg/kg/dose (adult 15-30mg) 8Horal. Periph vasc disc: 1.5mg/kg/dose (adult 75mg) 8H oral. o Cinchocalne . Max dose 2mg/kg (0.4ml/kg of 5%). o Cinoxacin . 10mg/kg/dose (adult 500mg0 12H oral. o Ciprofibrate . 2-4mg/kg (adult 100-200mg) daily oral. o Ciprofloxacin . 5-10mg/kg/dose (adult 250-500mg) 12H oral, 4-7mg/kg/dose (adult 200-300mg) 12H IV severe inftn, or cystic fibrosis: 20mg/kg/dose (max 750mg) 12H oral, 10mg/kg/dose

(max400mg) 8H IV; higher doses used occasionally. Meningococcus proph: 15mg/kg (max 500mg) once oral. Reduce dose of theophyline. o Ciprofloxacin, eye drops, 0.3%. Corneal ulcer: 2drop/15min for 6hr then 2drop/30min for 18hr(day 1), 2drop 1H (say 2), 2drop 4H (day 3-14).conjunctivitis: 1- 2drop 4H; if severe 1-2drop 2H

when awake for 2 days, then 6H. o Cisapride . 0.2mg/kg/dose (adult 5-15mg) 6-8H oral. o Cltasacurium . 0.1mg/kg (child) or 0.15mg/kg (adult) IV stat, then 0.03mg/kg if reqd or 1-3mcg/kg/min. ICU: 0.15mg/kg stat, then (1-10mcg/kg/min) IV. o Cisplatin . 60-100mg/m2 IV over 6hr every 3-4wk x6 cycles. o Citalopram . 0.4mg/kg (adult 20mg) daily, incr if reqd over 4wk to max 0,4mg/kg (adult 60mg) daily oral. o Cladribine . See 2- chlorodeoxyadenosine. o Clarithromycin . 7.5-15mg/kg/dose (adult 250-500mg) 12H oral. Slow release tab, adult (NOT/kg): 0.5g or 1g daily . o Clavulanic acid with amoxycillin or ticarcillin . Dose as for amoxycillin or ticarcillin. o Clemastine . 0.02-0.06mg/kg/dose (adult 1-3mg) 12H oral. o Clenbuterol . Adult (NOT/kg): 20mcg/dose (occasionally up to 40mcg/dose) 12H oral. o Clldinium . 0.05-0.1mg/kg/dose (adult 2.5-5mg) 6-8H oral. o Cllndamycin . 6mg/kg/dose (adult 150-450mg0 6H oral. IV or IM > 28 days: 10mg/kg/dose (adult 600mg) 8H (IV over 30min). Neonate: 5mg/kg/dose 12H (preterm<1wk old), 5mg/kg/dose 8h

(preterm>1wk, term<1wk), 7,5mg/kg/dose 8H (term >1wk) IV over 30min. Severe inftn (>28 days): 15-20mg/kg/dose (adult 900mg) 8H IV over 1hr. Acne soltn 1%: apply. o Clloquinol . 10mg/g cream, 1005 powder: apply 6-12H. o Clobazam . 0.1mg/kg (adult 10mg) daily oral, incr if reqd to max 0.4mg/kg/dose (adult 20mg) 8-12H oral. o Clobetasol . 0,05% cream or ointment: apply 12H. o Clobetazone . 0.1% soltn: 1-2drops/eye 1-6H. o Clodronate . See sodium clodonrate. o Clofazimine . 2mg/kg (adult 100mg) daily oral Lepra reaction: up to 6mg/kg (max 300mg) daily for max3mo. o Clofibrate . 10mg/kg/dose 8-12H oral. o Clomiphene . Adult: 50mg (NOT/kg): daily for 5 days oral, incr to 100mg daily for 5days if no ovulation. o Clomipramine. 0.5 - 1 mg/kg/dose (adult 25-50mg) 12H oral incr if to max 2mg/kg/dose (adult 100mg0 8H. o Clonazepam. 1 drop = 0.1mg.o.o1mg/kg/dose (max 0.5mg) 12H oral, slowly incr to 0.05mg/kg/dose (max 2mg) 6 -12H oral.Status(maybe repeated),NOT/kg : neonate 0.25mg (if ventilated,

child 0.5mg,adult 1mg IV. o Clonidine. 3 -5 mcg/kg slow IV, 1-6mcg/kg/dose (adult 50 - 300mcg) 8 - 12H oral. Migraine : start with 0.5mcg/kg/dose 12H oral. Analgesia : 2.5mcg/kg premed oral, 0.3mcg/kg/hr IV, 1-

2mcg/kg local block ; ventilated 0.5 - 2mcg/kg/hr (1mcg/kg/hr is 50mcg/kg in 50 ml at 1 ml/hr (< 12 kg) or 25mcg/kg in 50ml at 2ml/hr (>12 kg) + midazolam 1mcg/kg/min (3mg/kg in 50 ml at 1 ml/hr).

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o Clopidogrel. 1.5mg/kg (adult 75mg) daily oral. o Clorazepate. 0.3-2mg/kg (adult 15-90mg daily at night oral or 0.1-0.5mg/kg/dose (adult 5-30mg) 8H. o Clostridia antitoxin. See gas gangrene antitoxin. o Clotrimazole. Topical : 1% cream or solution 8-12H. Vaginal (NOT/kg): 1% cream or 100mg tab daily for 6 days, or 2% cream or 500mg tab daily for 3 days. o Cloxacillin. 15mg/kg/dose (adult 500mg) 6H oral, IM or IV.Severe inftn: 25-50mg/kg/dose (adult 1-2g) IV 12H (1 st wk life), 8H (2-4wk), 4-6H (>4wk) or constant infsn(>4wk). o Clozapine. 0.5mg/kg/dose (adult 25mg) 12H oral, incr over7-14 days to 2-5mg/kg/dose (adult 100-300mg) 8-12H; later reducing to2mg/kg/dose (adult 100mg) 8-12H. o Coagulation factor, human (prothrombinex).Factors 2, 9 and 10 ; 250 u/10ml. 1ml/kg slow IV daily. Risk of thrombosis in acute liver failure. o Coal tar topical : 0.5% incr to max 10%, applied 6-8H. o Cocaine. Topical 1-3mg/kg. o Codeine phosphate. Analgesic : 0.5-1mg/kg/dose (adult 15-60mg) 4H oral, IM;SC, Antitussive: 0.25-0.5mg/kg/dose (adult 15-30mg). o Co - dergocrine mesylate. Adult usually 3.0-4.5mg (NOT/kg) daily before meal oral or sublingial. 300mcg (NOT/kg) daily IM, SC or IV infsn. o Coenzyme Q 10. See ubidecaronone. o Colaspase.Test 2.50u intradermal. Typical dose 6000u/m2 every 3rd day x9 doses IV over 4hr, IM or SC. o Colesevelam . Adult (NOT/kg): 3.75-4.375g daily oral. o Colchicine. Acute gout: 0.02mg/kg/dose (adult 1mg) 2H oral (max 3 doses/day). Chronic use (gout, fmf): 0.01-0.04mg/kg (adult 0.5-2mg) daily oral. o Colesevelam. 625mg tab. Adult (NOT/kg): 3tab 12H oral, or 6tab daily. With statin: 4-6tab/day (in 1-2 doses). o Colestipol hydrochloride . 0.1-0.2g/kg/dose (adult 5-10g) 8H oral. o Colfosceril palmitate (Exosurf Neonatal). Soltn 13.5mg/ml. Prophilaxys: 5ml/kg intracheal over 5min immerdiately after birth, and at 12hr and 24hr if still ventilated. Rescue: 5ml/kg intracheal

over 5min, repeat in 12hr if still ventilated, o Collstimethate. See colistin sulfomethate sodium. o Collstin sulphomethate sodium. 2.6mg= 1mg colistin base= 30,000u. IM, or IV over 5min: 40,000u/kg/dose (adult 2 million u) 8H, or 1.25-2.5mg/kg/dose of colistin base 12H. Oral or inchaled:

30,000-60,000 u/kg/dose (adult 1.5-3million u) 8H. o Collstin 3mg/ml + neomycin 3.3mg/ml. Otic: 4drops 8H. o Colonic lavage (macrogol) soltns. Poisoning, severe constipation: if bowel sounds present, 30ml/kg/hr oral or NG for 4-8hr (until rectal effluent clear). Before colonoscopy: 1L (<1yr), 1.5-1.75L

(1-10yr), 2-3L (>10yr) oral, NG. o Colony stimulating factore . See ancestrim, epoetin, filgastrim, lenogastrim, molgramostim, sargramostim. o Coloxyl. See dioctyl sodium sulphosuccinate, poloxalkol. o Corticorelin . 1-2mcg/kg (max 100mcg) IV. o Corticotrophin releasing factore or hormone (CRF, CRH). See corticorelin. o Cortizone acetate. 1-2.5mg/kg/dose 6-8H oral. Physiological: 7.5mg/m2/dose 8H. Cortisone acatate 1mg= hydrocortisone 1.25mg in mineralo - and gluco- corticoid action. o Cosyntropin (ACTH subunlt). NOT/kg: <2yr 0.125mg,>2yr 0.25-0.75mg IM, IV, or infused over 4-8hr. o Cotrimoxazole (trimetrophim 1mg + sulphamethoxazole 5mg). TMP 1,5-3mg/kg/dose (adult 80-160mg) 12H IV over 1hr or oral. Reneal prophylaxis: TMP 2mg/kg (max 80mg) daily oral.

Pneumocytis: YMP 250mg/m2 stat, then 150mg/m2 8H (<11yr) or 12H (>10yr) IV over 1hr in renal failure dose interval (hr)= serum creatinine (mmol/l) x135 (max 48hr); 1hr post infsn serum TMP 5-10mcg/ml, SMX 100-200mcg/ml. IV infsn: TMP max 1,6mg/ml in 55 dext.

o Coumarin. Oral: 1-8mg/kg (adult 50-400mg) daily. Cream 100mg/g: apply 8-12H. o Coxlella burnetti vaccine. Inactivated. 0.5ml SC once. o Cromoglycate. See sodium cromoglycate. o Cromolyn, sodium. See sodium cromoglycate. o Croiton. 1-% cream or lotion; apply x2-3/day .

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o Cryoprecipitate. Low factor 8: 1u/kg incr avtivity 2%(half life 12hr); usual dose 5ml/kg or 1bag/4kg 12H IV for 1-2 infsn (muscle, joint0, 3-6onfsn (hip, forearm, retroperitoneal, oropharynx), 7-14 infsn (intracarnial0. low fibrinogen: usual dose 5ml/kg or 1bag/4kg IV. Abag is usually 20-30ml: factor 8 about 5u/ml and 100u/bag, fibrinogen about 10mg/ml and 200mg/bag.

o Cyanocobalamin (Vit B12). 20mcg/kg/dose (adult 1000 mcg) IM daily for 7 days then wkly (treatment), monthly (prophilaxys). Iv dangerious in mogalobastic anaemia. o Cycllzine. 1mg/kg./dose (adult 50mg) 8H oral, IM or IV . o Cyclobenzaprine. 0.2-0.4mg/kg./dose (adult 10-20mg) 8H oral. o Cyclopenthlazide. 5-10mcg/kg/dose (adult 250-500mcg) 12-24H oral. o Cyclophosphamide. A typical regimen is 600mg/m2 IV over 30min daily for 3days, then 600mg/m2 IV wkly or 10mg/kg twice wkly (if leucocytes >3000/mm3). o Cycloserine. 5-10mg/kg/dose (adult 250-500mg) 12h oral. Keep plasma conc< 30mcg/ml. o Cyclosporin. 1-3mcg/kg/min IV for 24-48hr, then 5-8mg/kg/dose 12H reducing by 1mg/kg//dose each month to 3-4mg/kg/dose4 oral. Eczema, juv arth, nephrotic, psoriasis: 1,5-2.5mg/kg/dose

12H. Trough level by Abbott TD x monoclonal specific assay (x 2.5= non spesific assay level) on whole blood (done Tu,fri 1400 at RCH): 100-250ng/ml (marrow), 300-400ng/ml first 3mo then 100-300ng/ml (kidney), 200-250 first 3mo then 11-125 (liver), 100-400ng/ml (hearth, lung).

o Cyclosporine. See cyclosporin. o Cyproheptadyne. 0.1mg/kg/dose (adult 4mg) 8-12H oral Migraine 0.1mg/kg(adult 4mg), repeated in 30min ig reqd. o Cyproterone acetate. 1mg/kg/dose (adult 50mg) 8-12H oral. Prec puberty; 25-50mg/m2/dose 8-12H oral. Hyperandrogenism: 50-100mg daily days 5-14, with oestradiol valerate 1mg daily

days 5-25. o Cyproterone acetate + ethinyloestradiol (2mg/35mcg) x 21tab, + 7 Inert tab. Contraception: 1 tab dail;y, starting 1st day of menstruation. o Cysteamine bitartrate. 0.05mg/m2/dose 6H oral, incr over 6wk to 0.33mg/m2/dose (<50kg) or 0.5mg/kg/dose (>50kg) 6H. o Cytarabine. Usually 100mg/m2 daily for 10 days by IV injn or constant infsn. Intracheal: 30mg/m2 every 4 days until CSF normal (dissolve in salline not diluent). o Cytomegalovirus Immunoglobn. See immunoglobn, CMV.

D o Dacarbazine. 250mg/m2 daily for 5days every 3wk. o Dacllzumab. 1mg/kg Iv over 15min every 2wk for 5 doses. o Dactinomycin. Usually 400-600mcg/m2 I(V daily for 5 days, repeat after 3-4wk. o Dalfopristin + quinupristin. See quinupristin. o Dalteparin sodium. Proph (adult): 2500-5000u Sc 1-2hr preop, then daily. Venous thrombosis (adult): 100u/kg/dose 12H SC, or infuse 200u/kg/day IV (anti-Xa 0.5-1u/ml 4hr post dose).

Haemodialisys: 5-10u/kg stat, then 4-5u/kg/hr Iv (acute reneal failure, anti Xa 0.2-0.4u/ml); 30-40u/kg stat, then 10-15u/kg/hr (chronic reneal failure, anti Xa 0.5-1u/ml). o Danaproid. Prevention: 15u/kg (adult 750u) 12H SC. Heparin induced Thrombocytopenia: 30u/kg stat IV, then 1.2-2u/kg/hr to maintain anti Xa 0.4-0.8u/ml. o Danazol. 2-4mg/kg/dose (adult 100-200mg) 6-12H oral. o Danthron. 1-6yr 25mg, 7-12yr 50mg, adult 100mg stat. o Dantrolene. Hyperpyrexia: 1mg/kg/min until impropves (max 10mg/kg), then 1-2mg/kg/dose 6H for 1-3day IV or oral. Spasticity: 0.5mg/kg/dose (adult 25mg) 6H, incr over 2wk if reqd to

3mg/kg/dose (adult 50-100mg) 6H oral. o Dapsone. 1-2mg/kg (adult 50-100mg) daily oral, Derm herpet: 1-6mg/kg (adult 50-300mg) daily oral. See also pyrimethamine. o Darbepoetin alfa. 0.45mcg/kg weekly, increased or reduced if reqd by 25% every 4wk. o Daunorubicin. 30mg/m2 wkly slow IV, or 60-90mg/m2 every 3wk, Max total dose 500mg/m2. o DDAVP. See desmopressin. o Deferoxamine. See desferrrioxamine. o Deflazacort. Usually 0.1-1.5mg/kg(adult 5-90mg) 24-48H oral. Prednisolone 1mg = 1.2mg defazacort in glucocorticoid activity. o Delavirdine mesylate. 8mg/kg/dose (adult 400mg) 8H oral.

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o Demecarium bromide. 0.125%, 0.25% ophthalmic soltn. Glaucoma: 1drop (child), 1-2 drop (adult) x2/day to x2/wk. Strabismus: 1drop daily for 2wk, then 1drop alternate days for 2-3wk. o Demeclocyline. >8yr: 3mg/kg/dose (adult 150mg) 6H, or 6mg/kg/dose (adult 300mg) 12H oral. o Denileukin diftitox. 9-18mcg/kg daily IV over 15min for 5 consecutive days every 21 days. o Deserpidine. 1-5mg/kg/dose (adult 25-50mg) 8-12H oral. o Desferrioxamine. Antidote: 10-15mg/kg/hr. IV for 12-24hr (max 6g/24hr) if Fe>60-90umol/l at 4hr or 8hr; some also give 5-10g (not/kg) once oral. Thalassaemia (NOT/kg): 500mg per unit

blood; and 5-6 nights/wk 1-3g in 5ml water SC over 10hr, 0.5-1.5g in 10ml water SC over 5min. o Deslpramine. 1-5mg/kg/dose (adult 25-50mg) 8-12H oral. o Desirudin. 0.3mg/kg/dose (adult 15mg) 12H SC. o Desloratadine. >12yr (NOT/kg): 5mg daily oral. o Desmopressin (DDAVP) . 1u= 1mcg. Nasal: 5-10mcg (0.05-1ml) per dose (NOT/kg) 12-24H; enuresis 10-40 mcg nocte. IV: 2mcg in 1L fluid, and replace urine output + 10% hrly. Haemopholia,

von wille: 0.3mcg/kg (adult 20mcg) IV over 1hr 12-24H. o Desogestrel + ethinyloestradiol (150mcg/30mcg) x21 tab, + 7 inert tab. Contraception: 1tab daily, starting 1st day of menstruation. o Desonide. 0.05% cream, onitment, lotion: apply 8-12H. o Desoximetasone. See desoxymetasone. o Desoxymethasone. 0.05% or 0.25% cream, ointment, gel: apply 12H. o Desoxyrbonuclease. See fibrinolysin. o Dexamethasone. 0.1-0.25mg/kg/dose 6H oral or IV. BPD: 0.1mg/kg/dose 6H for 3days, then 8H 3days, 12H 3days, 24H 3days, 48H 7days. Cerebral oedema: 1,5mg/kg(adult 10mg) stat, then

0.25mg/kg 4-6H (adult 4mg) IV, congen adr hypopl: 0.27mg/m2 daily, oral. Croup, severe: 0.6mg/kg (max 12mg)IM stat, then prednisolone 1mg/kg/dose 8-12H oral. Eye drops 0.1%: 1-2 drops per eye 3-8H. Dexamethasone has no mineralocorticoid action, but 1mg= 25mg hydrocortisone in glucocorticoid action

o Dexamphetamine. 0.2mg/kg (max 10mg) daily oral, oncr if reqd to max 0.6mg/kg/dose (max 40mg) 12H. o Dexchlorpheniramine maleate. 0.05mg/kg/dose (adult 2mg) 6-8H oral. Repetab (adult NOT/kg): 6mg 12H oral. o Dexfenfluramine. Adult: 15mg (NOT/kg) 12H oral. o Dexmedetomidine. ICU: 1mcg/kg IV over 15min, then 0.2-0.7mcg/kg/hr to max 24hr. o Dexmethylphenidate. NOT/kg, given as two doses/day 4hr apart: 2.5mg/kg/dose oral, incr if reqd to 10mg/dose. Use half the dose of racemic methylphenidate. o Dexpanthenol. 5-10mg/kg (adult 250-500mg) IM. 5% cream; apply 12-24H. o Dexrazoxane. 10mg for each 1mg doxorubicin IV. o Dextran 1(promit). 15% soltn, 0.3ml/kg IV 1-2min before giving dextran 70. o Dextran 40. 10% soltn: 10ml/kg/dose x1-2 on day 1, then 10ml/kg/day IV Half life about 3hr. o Dextran 70. 6% soltn: 10ml/kg/dose x1-2 on day 1, then 10ml/kg/day IV, Half life about 12hr. o Dextroamphetamine. See dexamphetamine. o Dextromethroophan hydrobromide. 0.2-0.4mg/kg/dose (adult 10-20mg) 6-8H oral. o Dextromoramide. 0.1mg/kg/dose (adult 5mg) 8H, may incr to 0.5mg/kg/dose (adult 20mg0 8H oral or PR. o Dextropropoxyphene, Hydrochloride 1.3mg/kg/dose (adult 65mg) or napsylate 2mg/kg/dose (adult 100mg) 6H oral. o Dextrose. Hypoglycaemia: 0,5ml/kg 50%D or 2.5ml/kg 10%D slow IV, then incr maintenance infsn rate. Hyperkalaemia: 0.1u/kg insulin + 2ml/kg 50%D IV. Neonates: 6g/kg/day (about

4mg/ka/min) day 1,incr to 12g/kg/day (up to 18g/kg/day with hypoglycaemia). Infsn ratye (ml/hr)= (4.17 x wt x g/kg/day) / %D= (6 x Wt x mg/kg/min)/ % D. Dose (g/kg/day)= (ml/hr x %D)/ (4.17 x Wt). Dose (mg/kg/min) = (ml/hr x %D)/ (6 x Wt). mg/kg/min = g/kg/day/ 1.44.0.5ml/kg/hr of 50% = 6g/kg/day.

o Dextrothyroxine. Adult (NOT/kg): 1-2mg daily oral, incr monthly if reqd to max 4-8mg daily. o Dezocine. IM: 0.1-0.4mg/kg/dose (adult 5-20mg) 3-6H, IV: 0.05-0.2mg/kg/dose (adult 2.5-10mg) 2-4H. o 3,4 - Diaminopyridine. Adult (NOT/kg): 10mg/ dose 6-8H oral, incr if reqd to max 20mg x5/day. o Diazepam. 0.1-0.4mg/kg (adult 10-20mg) IV or PR 0.04-0.2mg/kg/dose (adult 2-10mg) 8-12H oral. Do not give by IV infsn (binds to PVC). Premed: 0.2-0.4mg/kg oral, PR.

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o Diazoxide. Hypertension: 1-3mg/kg )max 150mg) stat by rapid IV injection (severe hypotension may occur) repeat once if reqd, then 2-5mg/kg/dose IV 6H, hyperinsulinism: <12mo 5mg/kg/dose 8-12H oral; >12mo 30-100 mg/m2 per dose 8H oral.

o Dibromopropamidine. 0.15% cream: apply on dressing prn. o Dibucalne. See cinchocaine. o Dichloralphenazone 100mg + Isometheptene mucate 65mg + paracetamol 325mg (Midrin), Adult (NOT/kg): 2 capsules stat, then 1/hr if reqd (max 5cap in 12hr). o Dichlorobenzene 2% + chlorbutol 5%. Otic (Cerumol):5 drops to ear 15-30min before syringing. o Dichlorphenamide. 2-4mg/kg (adult 100-200mg) stat, then 2mg/kg/dose (adult 100mg) 12H until response then 0.5-7mg/kg/dose (adult 50mg) 8-24H oral. o Diclofenac. 1mg/kg/dose (adult 50mg) 8-12H oral,PR,Eye drops 0.1%: preop 1-5drops over 3hr, postop 3drops stat, then 1drop 4-8H. Topical gel: apply 2-4g 6-8H. o Dicloxacillin. 15-25mg/kg/dose (adult 250-500mg) 6H oral, IM or IV. Severe inftn: 25-50mg/kg/dose (max 2g) IV 12H (1st wk life), 8H (2-4wk), 4-6H or constant infsn (>4wk). o Dicobalt edetate. 10mg/kg (adult 300mg) IV over 1-5min, repeat X2 if no response. o Dicyclomine. 0.5mg/kg/dose (adult 10-20mg) 6-8H oral. o Didanosine. Neonate 50mg/m2/dose 12H oral. Child 90mg/m2/dose 12H Adult 200mg/dose 12H. CNS disease: 150mg/m2/dose 12H. o Dideoxycytidine (ddc) . See zalcitabine. o Dienestrol . See dienoestrol. o Dienoestrol. 0.01% vaginal cream: 1 applicatorful (5g/dose) 12-24H for 1-2wk, reducing gradually to x1-3/wk. o Diethylcarbamazine. 6mg/kg daily for 12 days oral, or a single dose of 6mg/kg repeated every 6-12 months. o Diethylproplon hydrochloride. 6-12yr: 25mg (NOT/kg): 12H oral. >12yer: 25mg (NOT/kg) 6-8H oral. o Diethylstillboestrol. See stiboestrol. o Difenoxin 1mg and atropine 0.025mg. Adult (NOT/kg); 1-2 tab 6-8H oral. o Diflorasone. 0.05% cream , ointment: apply 6-24H. o Diflunisal. 5-10mg/kg/dose (adult 250-500mg) 12H oral. o Digitoxyn. 4mcg/kg/dose (max 0,2mg) 12H oral for 4 days, then 1-6mcg/kg (adult usually 0.15mg, max 0,3mg) daily. o Digoxin. 15mcg/kg stat and 5mcg/kg after 6H, then 3-5 mcg/kg/dose (usual max 200mcg IV, 250mcg oral) 12H slow IV or oral. Level 6hr or more after dose: 1.0-2.5nmol/L (x0.78 = ng/ml), done

Mo-Sat 1400 at RCH. o Digoxin Immune FAB (antibodies), IV over 30min. Dose (to nearest 40mg) = serum digoxyn (nmol/L) x Wt (kg) x 0.3, or mg ingested x 55. Give if > 0.3mg/kg ingested, or level>6,4 nmol/L or

5.0ng/ml. o Dihydrocodeine. 0.5mg/kg/dose 4-6H oral. o Dihydroergotamine mesylate. Adult (NOT/kg): 1mg IM, SC or IV, repeat hrly x2 if needed. Max 6mg/wk. o Dihydro morphinone. See hydromorphinone. o Dihydrotachysterol (1-OH vitamin D2). Renal failure, vit D resistant rickets: 20mcg/kg daily oral, incr by 20mcg/kg every 4-8wk according to serum calcium. o Dihydrotestosterone. See stanolone. o Dihydroxyacetone, 5% soltn: apply 1-3 coats 1hr apart every 1-3 days. o Dllodohydroxyquin. See di-iodohydroxyquinoline. o Di-iodohydroxyquinoline. 10-13mg/kg/dose (adult 650mg) 8H oral for 20 days. o Dlloxanide. 10mg/kg/dose (adult 500mg) 8H oral. o Dillitazem. 1mg/kg/dose (adult 60mg0 8H, incr if reqd to max 3mg/kg/dose (adult 180mg) 8H oral. Slow release (adult, NOT/kg): 120-240mg daily, or 90-180mg 8-12H oral. o Dimenhydrinate. 1-1.5mg/kg/dose (adult 50-75mg) 4-6H oral, IM or IV. o Dimercaprol BAL). 3min/kg/dose (max 150mg) IM 4H for 2 days, then 6h for 1day, then 12H for 10 days. o Dimethicone. 10%, 15% barrier cream: apply prn. o Dimehindene .0.02-0.04mg/kg/dose (adult1-2mg) 8H oral.

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o Dimethyl sulfoxyde (DMSO). 50% soltn: 50ml in bladder for 15min every 2wk. o Dinoprost (Prostaglandin F2 alpha). Extra- amniotic: 1ml of 250mcg/ml stat, then 3ml 2H. Intra-amniotic: 40mg stat, then 10-40mg after 24hr if required. o Dinoprostone (Prostaglandin E2). Labour induction: 1mg into posterior vagina, may repeat dose 1-2mg after 6hr (max 60mcg/kg over 6hr). Maintain PDA: 25mcg/kg 1H (less often after 1wk)

oral; or 0.003-0.01mcg/kg/min IV. o Dioctyl sodium sulphosuccinate. See docusate sodium. o Diphemanll methylsulphate. 20mg/g (2%) powder:apply 8-12H. o Diphenhydramine hydrochloride. 1-2mg/kg/dose (adult 50-100mg) 6-8H oral. o Diphenoxylate 2.5mg and atropine 25mcg tab (Lomotil). Adult (NOT/kg): 1-2 tab 6-8H oral. o Diptheria antitoxyn (horse). IM or IV (NOT/kg): 2500u (nasal), 10,000u(unilateral tonsillar),20,000u(bilateral tonsillar),30,000u(laryngeal), 50,000u(beyond tonsillar fossa), 150,000u(bullneck).

Repeat dose may be needed. See also immunoglobin, diphtheria. o Diptderia vaccine, adult (CSL). Inactivated. 0,5ml IM stat, 6wk later, and 6mo later (3 doses). Boost every 10yr. o Diptheria vaccine, child<8yr(CSL). Inactivated. 0.5ml IM stat, 6wk later, and 6mo later(3doses). Boost with adult vaccine. o Diptheria + pertussis (whole cell) + tetanus vaccine (Triple Antingen). Inactivated. 0.5ml IM at 2mo, 4mo, 6mo, 18mo, and 4-5yr of age (5doses). o Diptheria + pertussis (acellular) + tetanus vaccine (Infanrix, Triparcel). Inactivated. 0,5ml IM at 2mo, 4mo, 6mo, 18mo and 4-5yr of age (5 doses). o Diptheria + pertussis (acellular) + tetanus + hepatitis B vaccine (infanrix hep B). Inactivated. 0,5ml at 2mo, 4mo, 6mo (3doses), and (witout hep B) 18mo. o Diptheria + tetanus vaccine, adult (ADT). Inactivated. 0.5ml IM stat, 6 wk later, and 6mo later (3 doses).Boost every 10yr. o Diptheria + tetanus vaccine, child <8yr (CDT). Inactivated 0.5ml IM stat, 6wk later, 6mo later (3doses), Boost with ADT. o Dipiverin. 0.1% soltn: 1drop per eye 12H. o Diprophylline. Usually 15mg/kg/dose 6H oral or IM. o Dipyridamole. 1-2mg/kg/dose (adult 50-100mg0 6-8H oral. See also aspirin + dipyridamole. o Dirithromycin. 10mg/kg(adult 500mg) daily oral. o Disodium edetate. See trisodium edetate. o Disodium etidronate. See etidronate. o Disodium pamidronate. See pamidronate. o Disopyramide. Oral: 1.5-4mg/kg/dose (adult 75-200mg) 6H.IV: 2mg/kg (max 150mg) over 5min, then 0.4mg/kg/hr (max 800mg/day).Level 9-15umol/L (x0.3395 = mcg/ml). o Distigmine. Neurogenic bladder, megacolon: 0.01mg/kg (adult 0.5mg) IM daily, 0.1mg/kg (adult 5mg) oral daily. Myasthenia gravis: 0.1- 0.2mg/kg/dose 12-24 (max 20mg daily) oral. o Disulfiram. Adult(NOT/kg): 500mg oral daily for 1-2wk, then 125-500mg daily. o Dithranol. 0.1%-2% cream, ointment: start with lowest strength, apply daily, wash off after 10min incr to 30min. o Divalproex. Dose as for sodium valproate. o DMSA. See succimer. o Dobutamine. IV infsn 1-20mcg/kg/min:child see p.47;for 65kg adult 250mg in 50ml at 2ml/hr is 2.5mcg/kg/min. o Docetaxel. Initially 75-100mg/m2 over 1hr IV every 3wk. o Docosanol. 10% cream: apply 5 times a day. o Docusate sodium. NOT/kg: 100mg (3-10yr), 120-240mg(>10yr) daily oral. Enema (5ml 185 + 155ml water): 30ml(newborn), 60ml(1-12mo), 60-120ml(>12mo) PR. o Docusate sodium 100mg + bisacodyl 10mg.<2yr half suppos, 1-11yr half to 1 suppos,>11yr 1suppos daily. o Docusate sodium 50mg + sennoside 8mg, tab.>12yr: 1-4tab at night oral. o Dofetillide. 10mcg/kg/dose (adult 500mcg) 12H oral, less if renal impairment or increased QTc interval. o Dolasetron. Cancer:1.8mg/kg (adult 100mg) IV 30min before chemo, or 4mg/kg (adult 200mg) oral 1hr before chermo, Surgery: 1mg/kg (adult 50mg) oral at indruction, or 0.25mg/kg (adult

12.5mg) IV postop. o Domperidone. Oral: 0.2-0.4mg/kg/dose (adult 10-20mg) 4-8H .Rectal suppos: adult (NOT/kg) 30-60mg 4-8H.

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o Donepezil. Adult(NOT/kg): 5mg at night oral, incr to 10mg after 1mo if reqd. o Dopamine. IV infsn 1-20mcg/kg/min: child see p.47;for 65kg adult 200mg in 50ml at 2ml/hr is 2mcg/kg/min. o Dopexamine. IV infsn 0,5-6mcg/kg/min: child see p.47; for 65kg adult 50mg in 50ml at 2ml/hr is 0.5mcg/kg/min. o Dornase alpha (deoxyribonuclease I).NOT/kg: usually 2,5mg(max 10mg) inhaled daily (5-21yr), 12-24H (>21yr). o Dorzolamide. 2% drops: 1drop/eye 8-12H. o Dorzolamide 2% + timolol 0.5%. 1 drop/eye 12H. o Dothiepin. 0.5-1mg/kg/dose (adult 25-50mg) 8-12H oral. o Doxacurium. 50-80mcg/kg stat, then 5-10mcg/kg/dose IV. o Doxapram. 5mg/kg IV over 1hr, then 0.5-1mg/kg/hr for 1hr (max total dose 400mg). o Doxazosin. Usually 0.02-0.1mg/kg (adult 1-4mg) daily oral. o Doxepin. 0.2-2mg/kg/dose (adult 10-100mg) 8H oral. o Doxercalciferol (1.25-OH D2 analogue). Initially 0.2mcg/kg (adult 10mcg) oral, or 0.08mcg/kg (adult 4mcg) IV, x3/wk at end of dialysis. Aim for blood iPTH 150-300pg/ml o Doxorubicin. 30mg/m2 IV over 15min wkly, or 30mg/m2 daily for 2-3 days every 3-4 wk. total dose 480mg/m2 (300mg/m2 if mediastinal irradiation). o Doxorubicin, liposomal. Carcinoma: 50mg/m2 IV every 3wk. Kaposi: 20mg/m2 IV every 2wk. o Doxycicline. Over 8yr,: 2mg/kg/dose (adult 100mg) 12H for 2 doses, then daili oral. Severe: 2mg/kg/dose 12H. Malaria proph: 2mg/kg (adult 100mg) daily oral. o Doxylamine succinate.0.25-0.5mg/kg/dose (adult 12,5-25mg) 8H oral. Hypnotic: 0.5-1mg/kg (adult 25-50mg). o Dronabinol. Initially 5mg/m2/dose 2-4H (max4-6 doses per day) oral, slow incr by 2.5,mg/m2/dose to max 5mg/m2/dose 4H. o Droperidol. Antimetic: postop 0.02-0.05mg/kg/dose (adult 1.25mg) 4-6H IM or slow IV,chemother 0.02-0.1 (adult 1-5mg) 1-6H. Psychiatry, neuroleptanalgesia, IM or slow IV: 0.1mg/kg(adult

2.5mg) stat, incr if reqd to max 0.3mg/kg/dose (adult 15mg)4-6H. Psychiatry, oral: 0.1-0.4mg/kg/dose (adult 5-20mg) 4-8H. o Drospirenone 3mg + ethinyloestradiol 30mcg x 21 tab + 7 inert tab. Contrapception: 1 tab daily starting 1st day of menstruation. o Dotrecogin alfa ( protein c), activated. 24mcg/kg/hr for 96hr IV.Minor surgery: stop 2hr before, restart straight after. Major surgery: stop 2hr before, restart 12hr after. o Dyclonine hydrochloride. See dyclocaine hydrochloride. o Dydrogesterone. 0.2mg/kg/dose (asult 10mg) 12-24H oral. o Dyphylline. See diprophylline.

E o Econazole nitrate. Topical: 1% cream, powder or lotion 8-12H. Vaginal: 75mg cream or 150mg ovule twice daily. o Ecothiapate lodide. 0.03%, 0.06%, 0.125%, 0.25% soltn: usually 0.125% 1 drop/eye every 1-2days at bedtime. o Edrophonium. Test dose 20mcg/kg (adult 2mg), then 1min later 80mcg/kg (adult 8mg) IV.SVT: 0.15mg/kg(Max 2mg) incr to max 0.75mg/kg (max 10mg)IV. With atropine if reqd for side effects. o EDTA. See sodium calciumedetate. o Efavirenz. 350mg/m2 (adult 600mg) daily oral. o Eflornithine. 13,9% cream:apply 12H . o Eformoterol. Caps 12mg (NOT/kg): 1 cap (5-12yr) or 1-2 caps (adult) inhaled 12H. o Electrolyte solution. See glucose electrolyte solution. o EMLA cream. See licnocaine + prilocaine. o Emedastine. 0.5mg/ml soltn: 1drop/eye 12H. o Emulsifying ointment. Soap substitute or emollient for dry skin. o Enalapril.0.1mg/kg (adultr 2.5mg) daily oral, incr over 1wk if reqd to max 0.5mg/kg/dose (adult 5-20mg) 12H. o Enalaprilat. Usually 0.025mg/kg/dose (max 1.25mg) 6H IV, max 0.1mg/kg/dose (max 5mg) 6H. o Enoxacin. 4-8mg/kg/dose (adult 200-400mg) 12H oral.

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o Enoxaparin (1mg=100u). Treatment: 1.5mg/kg/dose (<2mo), 1mg/kg/dose (2mo-18yr), 40mg (adult) 12H SC(anti-Xa 0.5-1u/ml 4hr post dose).Prophilaxys: 0.75mg/kg/dose 12H (<2mo), 0.5mg/kg/dose 12H (2mo-8yr), 20-40mg 2-12hr preop, then daily (adult) SC. Haemodialysis: 1mg/kg into arterial line at start 4hr session.

o Enoximone. IV: 5-20mcg/kg/min. Oral: 1-3mg/kg/dose (adult 50-150mg) 8H. o Entacapone. Adult (NOT/kg): 1 tab with each i-dopa/DDC inhibitor dose (av 800-1400mg/day, max 2000mg) oral. o Enzymes, pancreatic. See pancreatic enzymes. o Epherdrine. 0.25-1mg/kg/dose (adult 12.5-60mg) 4-8H oral, IM, SC or IV. Nasal (0.25%-1%): 1 drop each nostril 6-8H, max 4 days. o Epinephrine. See adrenaline. o Epirubicin. Adult: 75-90mg/m2 IV over 10min every 3wk. o Epoetin alfa, beta. 20-50u/kg x3/wk, incr to max 240u/kg x1-3/wk SC, IV. When Hb> 10g%: 20-100u/kg x22-3/wk. o Epoprostenol( prostacylin, PG12).0.01mcg/kg/min IV.Chronic pul ht: 2ng/kg/min IV, incr to 20-40ng/kg/min. Pul vasodil: 0.01mcg/kg/min epoprost = 5mcg/kg/min notroglyc= 2mcg/kg/min

nitropr = 0.1mcg/kg/min PGE 1. o Eprosartan. 12mg/kg (adult 600mg) daily, incr if reqd to 6-8mg/kg/dose (adult 300-400mg) 12H oral. o Epsilon aminocaproic acid. See aminocaproic acid. o Eptacagoc alfa(recombinant factor 8). See factor 8. o Eptifibatide. Adult (NOT/kg): 180mcg/kg stat IV, then 2mcg/kg min for up to 72hr. o Ergocalciferol. See vitamin D2. o Ergoloid mesylates. See co-dercrocine mesylatye. o Ergrometyne maleate. Adult (NOT/kg): 250-500mcg IM or IV; 500mcg 8H oral, sublingual or PR. o Ergonovine maleate. See ergrometine maleate. o Ergotamine tartrate.>10yr(NOT/kg): 2mg sublingual stat, then 1mg/hr (max 6mg/episode, 10mg/wk). Suppos (1-2mg): 1stat, may repeat once after 1hr. o Ertapenem. 20-40mg/kg(adult 1g) daily IM or IV over 30min. o Erytromycin. Oral or slow IV(max 5mg/kg/hr): usually 10mg/kg/dose (adult 250-500mg) 6H; severe inftn 15-25mg/kg/dose (adult 0.75-1g) 6H. 2% gel: apply 12H. o Erythropoletin. See epoetin. o Escitalopram. Adult(NOTkg): 5mg daily oral, incr if reqd to max20mg daily. o Esmolol. 0.5mg/kg (500mcg/kl) IV over 1min, yhen 50mcg/kl/min for 4min; if poor response repeat 0.5mg/kg and give 50-200mcg/kg/min; rarely given for >48hr. o Esomeprazole. 0.4-0.8mg/kg (adult 20-40mg) daily oral. o Estazolam. 0.02-0.1mg/kg (adult 1-4mg) at night oral. o Estradiol.See oesrtradiol. o Estramustine. 200mg/m2/dose 8H oral. (avoid milk). o Estrogens. See oestrogens. o Estroplplate. Adult(NOT/kg): 0.625-7.5mg daily starting 1st day of menstruation, for 3 for every 4wks. Intravaginal: 2-4g cream daily. o Etanercept. 0.4mg/kg (max 25mg) twice wkly deep SC. o Ethacrynic acid. IV. 0.5-1mg/kg/dose (adult 25-50mg) 12-24H oral: 1-4mg/kg/dose (adult 50-200mg) 12-24H. o Ethambutol hydrochloride. 25mg/kg once daily for 8wk, then 15mg/kg daily oral. Intermittent: 35mg/kg x3/wk.IV: 80% oral dose. o Ethamsylate. 12.5mg/kg/dose (max 500mg) 6H oral, IM, IV. o Ethanol dehydrated (100%). Vessel sclerosis: inject max of 1ml/kg. o Ethanolamine oleate. 5% soltn, adult(NOT/kg): 1.5-5ml per varix (max 20ml per treatment). o Ethchlorvynol. 10-20mg/kg (adult 0.5-1g) at night oral. o Ethinyloestradiol. See desogestrel, drospirenone, ethynodiol, levonorgestrel, norethisterone, norgestimate, oestradiol, and progestin norelgrestomin. o Ethionamide. TB: 15-20mg/kg (max 1g) at night oral. Leprosy: 5-8mg/kg (max 375mg) daily.

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o Ethoheptazine. 3mg/kg/dose (adult 150mg) 6-8H oral. o Ethosuximide. 10mg/kg )adult 500mg) daily oral, incr by 50% each wk to max 40mg/kg (adult 2g) daily. Trough level 0.3-0.7mmol/L. o Ethotoin. 5mg/kg/dose (adult 250mg0 6H oral, incr to max 15mg/kg/dose (adult 750mg) 6H. o Ethynodiol diacetate + ethyniloestradiol (0.5mg/50mcg or 1mg/50mcg) x 21 tab, + 7 inert tab. Contraception: 1 tab daily, starting 1st day of menstruation. o Etidocaine. 0.5%-1.5% soltn: max 6mg/kg (0.6ml/kg of 1%) parenteral, or 8mg/kg (0.8ml/kg of 1%) with adrenaline. o Etidronate. 5-20mg/kg daily oral (no food for 2hr before and after xdose) for max 6mo. IV: 7.5mg/kg daily for 3-7 days. o Etodolac. 4-8mg/kg/.dose (adult 200-400mg) 6-8H oral. o Etomidate. 0.3mg/kg slow IV. o Etonogestrel. 68mg sub-dermal implant lasts 3yr. o Etoposide. 50-60mg/m2 IV over 1hr daily for 5 days, repeat after 2-4wk. Oral dose 2-3 times IV dose. o Etoricoxib. Adult (NOT/kg): 60-90mg daily oral. Gout: 120mg daily, max 8 days. o Etretinate. 0.25mg/kg/dose 8-12H oral for 2-4wk, then 6H (max 75mg daily) if reqd for 6-8wk, then 12-24H. o Exemestane. Adult (NOT/kg): 25mg daily oral.

F o Factor 8 concetrate (vial 200-250u), recombinant anti haemophilic factor (rAHF). Joint 20u/kg, psoas 30u/kg, cerebral 50u/kg. 2 x dose (u/kg) = % normal activity, eg 35u/kg gives peak level of

70% normal. o Factor 8 Inhibitor bypassing fraction. IV infsn max 2u/kg/min: joint 50u/kg/dose 12H, mucous mem 50u/kg/dose 6H, soft tissue 100u/kg/dose 12H, cerebral 100u/kg/dose 6-12H. o Factor 9. IV ifsn (max 2u/kg/min): minor he 25u/kg daily, joint 40u/kg 12-24H, surgery 50u/kg stat then 30u/kg 12-24H, mjor surgery 85u/kg stat then 50u/kg 12-24H. Prophylaxis: 25-40u/kg

x2/wk (trough>1u/dl). o Factor 9 complex (factor 2, 9, 10, and some 7). 40-60iu/kg, then 5-10iu/kg/dose 12H IV. Prophylaxis: 10-20iu/kg x1-2/wk. Factor 8 antibodies: 75iu/kg, repeat in 12hr pm. o Famciclovir. Zoster, varicella: 5mg/kg/dose (adult 250mg) 8H oral for 7 days; immunocompromised 10mg/kg/dose (adult 500mg) 8H for 10 days. Genital herpes (adult, NOT/kg): 125mg 12H

oral for 5 days (treat), 250mg (suppres) 12H; immunocompromised 500mg 12H for 7 days (treat), 500mg daily (suppres). o Famotidine. 0.5-1,g/klg/dose (adult 20-40mg) 12-24H oral. 0.5mg/kg/dose (max 20mg) 12H slow IV. o Fat emulsion 20%. See lipid emulsion. o Felbamate.5mg/kg/dose 6-8H (max 1200mg/day) oral, incr over 2-3wk to 15mg/kg/dose 6-8 (max 3600mg/day). o Felodipine. 0.1mg/kg(adult 2,5mg) daily, incr if reqd to 0.5mg/kg (adult 10mg) daily oral. o Fenbufen. 10mg/kg/dose (adult 450mg) 12H oral. o Fenfluramine. Adult (NOT/kg): 60mg daily oral. o Fenofibrate. 2mg/kg/dose (adult 100mg) 6-12H oral. o Fenoldopam. 0.1mcg/kg/min IV infsn incr gradually if reqd every 15-30min to max 1.6mcg/kg/min. o Fenoprofen.4mg/kg/dose (adult 200mg) 6-8H oral, may incr gradually to 12mg/kg/dose (max 800mg). o Fenoterol. Oral: 0.1mg/kg/dose 6H. Resp soltn 1mg/ml: 0.5ml/dose diluted to 2ml 3-6H (mild), 1ml/dose diluted to 2ml 1-2H (moderate) , undiluted continous ( severe, in ICU).Aerosol (

200mcg/puff): 1-2 puffs 4-8H. o Fentanyl. 1-2mcg/kg/dose (adult 50-100mcg) IM or IV; infuse 2-4mcg/kg/hr (< 25kg: 100mcg/kg in 50ml at 1-2 ml/hr>25kg: amp 50mcg/ml at 0.04-0.08ml/kg/hr). Ventitd: 5-10mcg/kg stat or

50mcg/kg IV over 1hr; infuse 5-10mcg/kg/hr (amp 50mcg/ml at 0.1-0.2ml/kg/hr). patch(lasts m72hr)in adult (NOT/kg): 25mcg/hr, incr if reqd by 25mcg/hr every 3 days. Epidural: 0.5mcg/kg stat, or 0.4mcg/kg/hr.

o Fenticonazole vaginal pessaries. 600mg nocte once, or 200mg nocte for 3 nights.

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o Ferrous salts. Prophylaxis 2mg/kg/day elemental iron oral, treatmenr 6mg/kg/day elemental iron oral. Fumarate 1mg=0.33mg iron. Gluconate 1mg=0.12mg iron; so Fergon(60mg/ml gluconate) prophylaxis 0.3ml/kg daily, treatment 1ml/kg daily oral. Sulphate (dried) 1mg=0.3mg iron; so Ferro-Gradument(350mg dried sulphate) prophylaxis 7mg/kg (adult 350mg) daily, treatment 20mg/kg (adult 1050mg) daily oral.

o Fexofenadine. 1,2mg/kg/dose (adult 60mg) 12H oral. o Fibrin glue. See thrombin glue. o Fibrinolysin 8-10u/ml and desoxyribonuclease 500-667u/ml. Ointment or soltn: apply topically 6-24H. o Fllgrastim (granulocyte CSF). Idiopathic or cyclic neutropaenia: 5mcg/kg daily SC or IV over 30min. Congenital neutropaenia: 12mcg/kg daily SC or IV over 1hr. Marrow transplant: 20-30mcg/kg

daily IV over 4-24hr, reducing if neutrophilis >1x10/L . o Finasteride. Adult (NOT/kg): 5mg daily oral. o Flavoxate. 2-4mg/kg/dose (adult 100-200mg) 6-8H, or single dose a bedtime oral. o Flecanide. 2-3mg/kg/dose (max 100mg) 12H oral, may incr over 2wk to 7mg/kg/dose (max 200mg0 8-12H. IV over 30min : 0.5-2mg/kg/dose (max 150mg) 12H. o Floxuridine (FUDR). 100-300mgc/kg/day by constants intra arterial infsn ( 400-6-mcg/kg/day in hepatic artery). Stop if WCC< 3500/mm3 or platelets< 100,000/mm3). o Flucloxacillin. Oral; 12.5-25mg/kg/dose(adult 250-500mg) 6H.IM or IV: 25mg/kg/dose (adult 1g) 6H . Severe inftn: 50mg/kg/dose (adult 2g) IV 12H (1st wk life). 8H(2-4wk), 6H or constant infsn

(>4wk). o Fluconazole. 6mg/kg (adult 200mg) stat, then 3mg/kg (adult 100mg) daily oral or IV. Severe inftn: 12mg/kg (adult 400mg) stat, then 6-12mg/kg (adult 200-400mg) daily IV. o 400-1200mg/m2/dose (max 2g) 6H IV over 30min, or oral. Peak level 50-100mcg/ml, trough 25-50mcg/ml (x7.75=umol/L). o Fludarabine.25mg/m2 daily x5 over 30min, repeated every 28 days. o Fludrocortisone acetate. 150mcg/m2 daily oral. Fludrocortisone 1mg= hydrocortisone 125mg in mineralocorticoid activity, 10mg in glucocorticoid. o Flumazenil. 5mcg/kg every 60sec to max total 40mcg/kg (adult 2mg), then 2-10mcg/kg/hr IV. o Flunisolide. Asthma ( 250mcg/puff): 1-2 puffs 12H. Nasal (25mcg/puff): 1-2 puffs/nostril 8-24H. o Flunitrazepam.Adult (NOT/kg): 0.5-2mg at night, oral. o Fluonicolone.See fluonicolone. o Fluocinonide.0.025%, 0.05% cream or oint: apply 6-12H. o Fluocortolone. 0.25% cream, ointment : apply 8-12H. o Fluorescein. 1%, 2% drops: 1-2 drop/eye. 10% (100mg/ml), 25% (250mg/ml); 8mg/kg (max 500mg) IV. o 5 - Fluorocytosine . See 5-flucytosine. o 9 - alpha - fluorohydropcortisone. See fludrocortisone. o Fluorometholone. 0.1% soltn: 1-2drops/eye 6-12H. o Fluorouracil. 3.33% + adrenaline 0.1%. Gel: inject into each wart x1/wk for up to 6wk. o Fluorouracil. 15mg/kg (max 1g) IV over 4hrv daily until side effects, then 5-10mg/kg wkly. See folinic acid. o Fluoxetine. 0.5mg/kg (max 20mg) daily, incr to max 1mg/kg/dose (max 40mg) 12H oral. Weekly 90mg cap: 1 per wk. o Fluoxymesterone. 0.1-0.2mg/kg (adult 5-10mg) daily oral. o Flupenthyxol. Oral: 0.05-0.2mg/kg/dose (adult 3-9mg) 12H. Depot IM: usually 0.4-0.8mg/kg (up to 5mg/kg, max 300mg) every 2-4wk (1mg flupenthixol deconate = 0.625mg fluphenazine

decanoate = 1.25mg haleporidol). o Fluphenazine. 0.02-0.2mg/kg/dose (adult 1-10mg) 8-12H oral. o Flurandrenolide. See flurandrenolone. o Flurandrenolone. 0.025%, 0.05% cream, ointment or lotion: apply 6-24H. 4mcg/m2 tape: apply 12H. o Flurazepam. Adult (NOT/kg): 15-30mg at night, oral. o Flurbiprofen. 1-2mg/kg/dose (adult 50-100mg) 8H oral or PR. 0.03% drops: 1drop/eye every 30min x4 doses. o Flutamide. Adult(NOT/kg): 250mg 8H oral.

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o Fluticasone. Inhaled(NOT/kg): 50-100mcg/dose (child), 100-500mcg/dose (adult) 12H. 0.05% soltn: 1-4 sprays/nostril daily . 0.05% cream: apply sparingly daily. o Fluticasone + salmeterol. Accuhaler(NOT/kg): 100/50 (child), 250/50 or 500/50 (adult) x1-2 inhltn 12H. MDI (NOT/kg): 50/25 (child) , 125/25 or 250/25 x1-2 inhltn 12H. o Fluvastatin. 0.4mg/kg (adult 20mg) nocte oral, incr to 0.8mg/kg (adult 40mg) nocte if required. o Fluvoxamine. 2mg/kg/dose (adult 100mg) 8-24H oral. o Folic acid. NOT/kg: Deficiency: 50mcg (neonate) , 0.1-0.25mg (<4yr), 0.5-1mg(>4yr) daily IV, IM SC, or oral. Metabolic disease: 5mg/day oral. Pregnancy: 0.5mg (high risk 4mg) daily oral. o Folinic acid. See calcium folinate. o Follicle stimulating hormone (FSH). Adult (NOT/kg): monitor urinary oestrogen. Anovulation: usually 50-150iu SC daily for 9-12 dats. Supervulation (2wk after starting GnRH agonist): 100-

225iu/kg daily starting day 3 of cycle. o Follitropin alpha, beta. See follicle stimulating hormone. o Fomivirsen . Intravitreal injection, adult (NOT/kg). New disease: 165mcg/eye wkly x3, then every 2wk. Previously treated: 330mcg/eye stat, in 2wk, then every 4wk. o Fondaparinux. See fondaparin. o Fondaparin. Adult (NOT/kg): 2.5mg SC 6hr postop, then daily for 5-9 days. o Formestane. Adult (NOT/kg): 250mg 2wkly deep IM. o Formoterol. >4yr (NOT/kg): 12mcg inhalation 12H. o Foscarnet. 20mg/kg IV over 30min, then 200mg/kg/day by constant IV infsn (less if creatinine>0.11mmol/L) or 60mg/kg/dose 8H IV over 2hr. Chronic use: 90-120mg/kg IV over 2hr daily. o Fosfestrol. Adult (NOT/kg): Initial: 0.5g IV over 1hr day 1, then 1g x5 days. Maintenance: 120-240mg/dose 8H oral, later reducing to 120-240mg daily. o Fosfomycin tromethamine. One 5.63g ( 3g base) sachet mixed with water once oral. o Fosinopril. 0.2-0.8mg/kg (adult 10-40mg) daily oral. o Fosphenytoin, 75mg = 50mg phenytoin (qv), Precribed and dispensed as phenytoin equivalents. o Fotemustine. IV, over 1hr, or IA over 4hr: 100mg/m2 weekly x3, rest 4-5wk, then every 3wk. o Framycetin sulfate ( Soframycin). Subconjunctival: 500mg in 1ml water daily x3 days. Bladder: 500mg i9n 50ml saline 8H x10 days. Eye/ear 0.55: 2-3drops 8H, ointment 8H. o Framycetin sulfate 15mg/g + gramicidin 0.05mg cream or ointment (solframycin topical): apply 8-12H o Framycetin sulfate 5mg + gramicidin 0.05mg + dexamethasone 0.5mg/ml ( Sofradex). Eye/ear 2-3drops 6-8H ointment 8-12H. o Fresh frozen plasma. Contains all cloting factors. 10-20 ml/kg IV. 1bag is about 230ml. o Frovatriptan. Adult (NOT/kg): 2.5mg oral (max 7.5mg/day). o Frusemide. Usually 0.5-1mg/kg/dose (adult 20-40mg) 6-24H (daily if preterm) oral, IM or, IV over 20min ( no faster than 0.05mg/kg/min) IV infsn: 0.1-1mg/kg/hr. o Fulvestrant. Adult (NOT/kg): 250mg IM once a month. o Furazolidone. 2mg/kg/dose (adult 100mg) 6H oral 7-10 day. o Furosemide. See furosemide. o Fusafungine. 12mcg spray: oral 1 spray/10kg (adult 5 sprays) x5/day, nasal 1 spray/20kg (adult 3 sprays) x5/day. o Fusidate, sodium. See sodium fusidate. o Fusidic acid. Fusidic acid (susp) absorption only 70% that of sodium fusidate (tabs). Suspensions: 15-20mg/kg (adult 750mg) 8H oral. For tablets and IV, see sodium fusidate.

G o Gabapentin. 10mg/kg (adult 300mg) once day 1 oral, 12H day 2, day 3 then adjusted to 10-20mg/kg/dose (adult 300-1200mg) 8H. o Galantamine. Adult (NOT/kg): 4mg 12H for 4wk, then 8mg 12H, incr after 4wk if reqd to 8-12mg 12H oral. o Gallamine. 1-2mg/kg/dose (adult 50-100mg) IV. o Gallium nitrate. 100-200mg/m2/day for 5 days by constant IV infsn. o Gamma benzene hexachloride. See lindane. o Gamma globulin. See immunoglobulin.'

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o Gamolenic acid. 2-5/kg/dose (adult 120-240mg) 12H oral. o Ganciclovir. 5mg/kg/dose 12H IV over 1hr for 2-3wk; then 5mg/kg IV dailt, or 6mg/kg IV on 6 days every wk, or 20mg/kg/dose (adult 1g) 8H oral. Congenital CMV: 7.5mg/kg/dose 12H over 2hr. o Ganirelix. Adult (NOT/kg): 0.25mg daily SC from day 6 of FSH to day of ovulation induction. o Gas gangrene (Clostridia) antitoxin. Prophylaxis: 25,000u IM or IV. Treatment: 75,000-150,000u IV over 1hr, repeat x1-2 after 8-12hr: if severe also give 100,000u IM. o Gatifloxacin. 8mg/kg (adult 400mg) daily IV over 1hr, Gonorrhoea: 8mg/kg (adult 400mg) once. o Gaviscon. See alginic acid. o Gelatin, succinylated. 10-20ml/kg (may be repated). Volume effects lasts 3-4hr. o Gemcitabine. 1000mg/m2 IV over 30min wkly for 3wk, rest for 1wk, then repeat 4wk cycle. o Gemeprost (PGE1 anlogue).Cervical dilatation: 1pessary (1mg) into posterior vagina 3hr before surgery. Termination: 1pessary (1mg) into posterior vagina 3H (max 5 pessaries). o Gemfibrozil. 10mg/kg/dose (max 600mg) 12h oral. o Gemtuzumab ozogamicin. 9mg/m2 IV over 2hr, repeated after 14 days. o Gentamicin. Single daily dose IV or IM. Neonate: 5mg/kg stat, then 2.5mg/kg (<30wk) 3,5mg/kg (<30wk) 3,5mg/kg(30-35wk) 5mg/kg(term<1wk) daily. 1wk-10yr: 8mg/kg day1, then 6mg/kg

daily,>10yr: 7mg/kg day 1, then 5mg/kg daily (max 240-360mg) daily. Trough level <1.0mg/L, done daily 1000, 1600,2200 at RCH. o Gestodene + ethynyloestradiol (75mcg/30mcg) x 21 tab + 7 inert tab. 1tab daily, starting 1st day of menstruation. o Gestodene + ethinyloestradiol ( 50mcg/30mcgx6tab; 70/40x5; 100/30x10; Inertx7).1tab daily. Starting 1st day of menstruation. o Gestrinone. Adult (NOT/kg): 2.5mg x2/wk on day 1 and 4 of menstrual cycle, then on same dys each wk. o Gestronol. Adult (NOT/kg): 200-400mg every 5-7 days IM. o Ginkobiloba. Adult (NOT/kg): 1200mg 12H oral. o Glatiramer acetate. Adult(NOT/kg): 20mg daily SC. o Glibenclamide.Adult (NOT/kg): initially 2,5mg daily oral, max 20mg daily. o Glibenclamide + metformin. Adult(NOT/kg): 1.25mg/250mg 12-24H oral, incr if reqd to 2.5mg/500mg or 5mg/500mg (max 10mg/1000mg) 12H. o Gliclazide. Adult (NOT/kg): initially 40mg daily oral, max 160mg 12H. o Glimepiride. Adult (NOT/kg): 2-4mg (max 6mg) daily oral. o Glipizide. Adult (NOT/kg): initially 5mg daily oral, max 20mg 12H. o Gliquidone. 0.25-1mg/kg/dose (adult 15-60mg) 8-12H oral. o Globulin. See immunoglobulin. o Glucagon. 1u= 1mg.0.04mg/kg (adult 12mg) IV or IM stat, then 10-50mcg/kg/hr (0.5mg/kg in 50ml at 1-5ml/hr) IV.Bete-blocker overdose: 0.1mg/kg IV stat, then 0.3-2mcg/kg/min. o Glucose. See dextrose. o Glucose electrolyte solution. Not dehydrated: 1heaped teaspoon sucrose in a large cup of water ( 4% sucrose= 2% glucose); do NOT add salt. Dehydrated: 1 sachet of Gastrolyte in 200ml

water; give frequent small sips, or infuse through a nasogastric tube. o Glutamic acid. 10-20mg/kg (adult 0.5-1g) oral with meals. o Glyburide.See glibenclamide. o Glycerol, Suppos (NOT/kg): 700mg infant, 1,4g child, 2,8g adult. o Glyceryl trinitrate. Adult (NOT/kg): sublingual tab 0.3-0.9mg/dose (lasts 30-60min); sublingual aerosol 0.4-0.8mg/dose; slow-release buccal tab 1-10mg 8-12H; transdermal 0.5-5cm of 2%

ointment, or 5-15mg patch 8-12H. IV infsn 1-10mcg/kg/min : child see p.47; adult 50mg in 50ml at 0.8ml/hr is 0.2mcg/kg/min; use polyethylene-lined syringe and tubing (not PVC) pul vasodil; 5mcg/kg/min nitroglyc = 2mcg/kg/min nitropr = 0.1mcg/kg/min PGE1.

o Glycopyrronium bromide . Dose as for glycopyrrolate. o GM - CSF . See sargramostrim. o Gold sodium lomalate. See sodium aurothiomolate. o Gonadorelin (GnRH or LHRH). Pituitary function test, child or adult; 100mcg IV. See also leuprorelin.

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o Gonadotrophin. See chorionic gonadtm, and menotrophin. o Goserellin. Adult (NOT/kg): 3.6mg SC every 28 days; implant 10.8mg SC every 12wk. o Gramicidin 25mcg/ml + neomycin 2.5mg/ml + polymyxin B 5000u/ml (Neosporin). Eye drops; 1-2 drops/eye every 15-30min, reducing to 6-12H. o Granisetron. 0.05mg/kg (max 3mg) IV over 10min; up to 3 doses/day, with at least 10min between doses. o Granulocyte - macrophage colony stimulating factor ( GM-CSF). See lenograstim, sargramostrim. o Growth hormone. See somatropin. o Guaifenesin. See guaiphenesin. o Guaiphenesin. 4-8mg/kg/dose (adult 200-400mg) 4H oral o Guanabenz 0.1mg/kg/dose (max 4mg) 12H oral, incr to max 0.6mg/kg/dose (max 32mg) 12H. o Guanadrel. 0.1mg/kg/dose (max 5mg) 12H oral , incr to max 0.5mg/kg/dose (max 25mg) 8-12H. o Guanfacine. 0.02mg/kg (max 1mg) daily oral, incr over several wks to max 0.06mg/kg (max 3mg) daily. o Guar gum. 1g/10kg (adult 5g) 8H oral in fluid 40ml/g gum.

H o Haem arginate. 3-4mg/kgdaily IV over 30-60min. o Haemaccel. See polygeline. o Haemophylus influenzae type b, vaccines. Inactivated. <12mo; give diphteria protein cunjugate (Hib TITER, Pro HiBiT), or tetanus cunjugate (Act-HIB, Hiberix) 0.5ml IM at 2mo, 4mo, 6mo and

15mo; or meningococcal conjugate (Pedvax HIB) 0.5ml IM at 2mo, 4mo and 15mo. If 1st dose>18mo; give 1dose of Hib TITER or Pedvax HIB. o Haemophylus influenzae type b + hepatitis B vaccine ( Comvax). Inactivated. 0.5ml IM 2mo, 4mo, 12-15mo (3 doses). o Halcinonide. 0.1% cream: apply sparingly 8-12H. o Halobetasol. 0.05% cream, ointment: apply 12-24H. o Halofantrine. 10mg/kg/dose (max 500mg) 6H for 3 doses oral, repeat after 1wk if nonimmune. o Haloperidol. 0.01mg/kg (max 0.5mg) daily, incr up to 0.1mg/kg/dose 12H IV or pral; up to 2mg/kg/dose (max 100mg) 12H used rarely. Acutely disturbed: 0.1-0.2mg/kg (adult 5-10mg) IM.

Long-acting decanoate seter: 1-6mg/kg IM every 4wk. o Hemin. 1-3mg/kg/dose 12-24 IV over 30min. o Heparin. 1mg= 100u. Low dose : 75u/kg stat, then 10-15u/kg/hr IV (500u/kg in 50ml at 1ml/hr = 10u/kg/hr). Full dose: 75u/kg (adult 5000u) stat, then 30u/kg/hr (<12mo).20u/kg/hr (child),

15u/kg/hr (adult) iv adjusted to give APTT 60-85 sec ( anti - Xa 0.3-0.7u/ml). Heparin lock 100u//ml. o Heparin calcium. Low dose: 75u/kg/dose SC 12H. o Heparin, low molecular weight. See certoparin, dalteparin, danaparoid, enoxaparin, nadroparin. o Hepatitis A vaccine (Havrix). Inactivated 0.5ml (child) or 1ml (adult) IM stat, and after 6-12mo (2doses). Boost every 5yr. o Hepatitis A vaccine (VAQTA). Inactivated0.5ml (child) or 1ml (>17yr) IM stat, and after 6-18mo (2doses). o Hepatitis A + hepatitis B vaccine (Twinrix), Inactivated 1-15yr 0,5ml, >15yr 1ml stat, after 1mo, and after 6mo (3doses) Boost every 5yr. o Hepatitis B vaccine (Engerix - B HB Vax II). Inactivated Engerix - B 10mcg/dose (<10yr), (>9yr): HB Vax II 2.5mcg/dose (<10yr), 5mcg (10-19yr), 10mcg (>19yr), 40mcg (dialysis) IM stat, after

1mo, and after 6mo (3 doses). Boost every 5yr approx. See also diptheria and haemophillus vaccines. o Hetastarch. 6% 10-20ml/kg IV. o Hexachloropane. 3% emulsion >12mo: apply 5ml, scrub for 3min. o Hexamethylmelamine. 150-260mg/m2 dily oral for 14-21 consecutive days of a 28 day cycle. o Hexamine. 20mg/kg/dose (adult 1g) 6H oral. o Hexetidine.0.1% soltn: rinse/gargle 15ml (NOT/kg): 8-12H. o Histamine phospate. 1mg/ml base; prick, puncture or scrath testing. 0.1mg/ml base; intradermal testing.

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o Histrelin. Usually 10mcg/kg daily SC. o Homatropine. 2%, 5% sltn:1-2drop/eye 4H. o Human chorlonic gonadotrophin. See chorionic gonadotrophin. o Human menopausal gonadotrophin.See menotrophin. o Hyaluronidase. Hypodermoclysis; add 1-1.5u/ml fluid. Local anaesthesia; add 50u/ml soltn. o Hydralazine. 0.1-0.2mg/kg (adult 5-10mg) atat IV or IM then 4-6mcg/kg./min (adult 200-300mcg/min) IV Oral 0.4mg/kg/dose (adult 20mg) 12H, slow incr to 1.5mg/kg/dose (usual max 50mg)

6-8H. o Hydrochloride acid. Use soltn of 100mmol/L (0.1M = 0.1N = 100mEq/L); give IV by central line only. Alkalosis; dose (ml) = BE x Wt x 3 (give half this); maximum rate 2ml/kg/hr. Blocked central

line; 1.5ml/lumen over 2-4hr. o Hydrochlorothiazide. 1-1.5mg/kg/dose (adult 25050mg) 12-24H oral. o Hydrochorothiazide + quinapril 10/12.5,20/12,5.Adult (NOT/kg): 10.12.5 tab daily oral, incr if reqd to 20/12.5 tab, max two 10/12,5 tab daily. o Hydrocodone. 0.1-0.2mg/kg/dose (max 10mg) 4-6H oral. o Hydrocortisone. Usually 0.5-2mg/kg/dose (adult 25-50mg) 6-8H oral, reducing as tolerated 0.5%, 1% cream, ointment: apply 6-12H, 1% cream + clioquinol: apply 8-24H. 10% rectal foam:

125mg/dose. o Hydrocortisone sodium succinate.2-4mg/kg/dose 3-6H IM, IV reducing as tolerated. Physiological: 5mg/m2/dose 6-8H oral; 0,2mg/kg/dose 8H IM, IV, Physiological, stress;1mg/kg/dose 6H IM,

IV. o Hydroflumethiazide. 0.5-2mg/kg/dose (adult 25-100mg) 12-48H oral. o Hydrogen peroxide. 10 volume(3%). Mouthwash 1:2 parts water. Skin or ear disinfectant 1:1 part water. o Hydromorphone. Oral 0.05-0.1mg/kg/dose (adult 2-4mg) 4H. IM, SC: 0.02-0.05mg/kg/dose (adult 1-2mg) 4-6H, slow IV: 0.01-0.02mg/kg/dose (adult 0.5-1mg) 4-6H. o Hydroquinone, 4%cream : apply 12H. o Hydrotalcite. 20mg/kg/dose (adult 1g) 6H oral. o Hydroxocobalamin (Vit B12). 20mcg/kg/dose (adult 1000mcg) IM daily for 7 days then wkly (treatment), then every 2-3mo (prophyl); IV dangerious in megaloblastic anaemia, Homcystinuria,

methylmalonic acidur: 1mg daily IM. o Hydrociapatite, 20-40mg/kg/dose (adult 1-2g) 8H oral. o Hydroxychloroquine sulphate. Doses as sulphate. Malaria: 10mg/kg (max 600mg) daily for 3 days; prophylaxis 5mg/kg (max 300mg) once a wk oral. Arthritis, SLE: 3-6.5mg/kg (adult 200-

600mg) daily oral. o Hydroxyethilcellulose. 0.44% 1-2drops per eye 6-8H. o Hydroxypropyl (methyl) cellulose.5mg insert: 1 in each eye daily. o Hydroxyquinone. 4% cream : apply 12H. o Hydroxyurea. 80mg/kg oral every 3 rd day, or 20-30mg/kg daily. CNS tumors: 1.5-3g/m2 oral stat, in 2wk, then every 4-6wk. Sickle cell: 15mg/kg daily, incr by 5mg/kg every 12wk to max

35mg/kg daily. o Hydroxyzine. 2mg/kg/dose (adult 25-100mg) 6-8H oral. 0.5-1mg/kg/dose (adult 25-100mg) 4-6H if reqd IM. o Hylan. 8mg inj into knee wkly x3; max 6 doses in 6mo. o Hyoscine . 0.01mg/kg/dose (max 0.6mg) 6H, IM or IV. Transdermal p-atch; 1,5mg patch: >10yr 1 every 72hr. o Hyoscine hydrobromide. 6-8mcg/kg (max 400mcg0 6-8H IV, IM, SC. Motion sickness 300mcg tab (NOT/kg): 0.25 tab (2-7yr), 0.5tab (7-12yr), 1-2 tab (>12yr) 6-24H oral 30 min before, may

repeat in 4hr. o Hyoscine n - butylbromide. 0.5mg/kg/dose (adult 20-40mg) 6-8H IV, IM or oral. o Hyoscyamine (L - atropine). 2-5mcg/kg/dose (adult 100-300mcg) 4-6H oral, sublingual, IM or IV . o Hyperimmune bovine colostrum, antirotavirus. 5g sachet + 20ml warm water + 10ml milk: 1/3 (10ml) of this 8H until 3 days after inftn risk. o Hypromellose 0.3% + dextran 70 0.1% . 1-2 drop/eye prn.

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o Hypromellose.0.5% soltn: 2-3 drop/eye pm.

I o Ibandronic acid. Hypercalcaemia (adult, NOT/kg): 2-4mg IV over 2hr once. o Ibuprofen. 5-10mg/kg/dose (adult 200-400mg) 4-8H oral, Arthritis: 10mg/kg/dose (adult 400-800mg) 6-8H . Cystic fibrosis: 20-30mg/kg/dose 12H. PDA: 10mg/kg stat, then 5mg/kg after 24

and 48 hr IV over 15min. o Ibutilide. -0.017mg/kg (max 1mg) IV over 10min, then wait 10min and repeat once if reqd. o Ichtammol. 1-10% cream, ointment. Apply 6-8H. o Icodextrin 7.5% in electrolyte soltn. Adults: 1,5-2,5 literss as once daily replacement for a 6-12hr glucose dialysis. o Idarubicin. 12mg/m2 IV over 15min daily for 3 days. o Idebenone. Adult (NOT/kg); 30mg/dose 8H oral. o Idoxuridine. 0.1% eye drops; 1-2 drops every 15min for 2hr, then hourly by day and 2H at night. 0.1% soltn or 0.5% ointment; apply hourly first 24hr, then 4H. o Ifosfamide. Usually 1.2-2.0g/m2 IV over 4hr daily x5, or 5-6g/m2 (max 10g) IV over 24hr once. Repeat every 2-4wk. o Imatinib mesylate. Adult (NOT/kg): 400mg daily (chronic CML), 600mg daily (blast crisis) or 400mg/dose 12H (unresponsive blast) oral. o Imidapril. 0.1mg/kg (adult 5mg0 daily oral, incr if reqd to 0.2-0.3mg/kg (adult 10-20mg) daily. o Imiglucerase.Usual initial dose 60u/kg every 2wk IV on\ver 2hr, adjusted according to response; reduce every 3-6mo. o Imipenem - cilastatin. 15mg/kg/dose (adult 500mg) 6H IV over 30min. severe inftn; 25mg/kg/dose IV over 1hr (adult 1g) 12H ( 1st wk life), 8H (2-3wk) 6-8H or constant infsn (4+ wk). o Imipramine. 0.5-1.5mg/kg/dose (adult 25-75mg) 8H oral. Enuresis; 5-6yr 25mg, 7-10yr 50mg, >10yr 50-75mg nocte. o Imiquimod. 5% cream: apply x3/wk (max 16wk) before bed; wash off after 6-10hr. Molluscum; 0.2% cream x3/wk. o Immunoglobin. See also antivenoms. o Immunoglobin, CMV. 100-200mg/kg IV over 2hr, Transplant; daily for first 3 days, wklty x6, monthly x6. o Immunoglobin, diphtheria. 250u IM once. o Immunoglobin hepatitis B. 400u IM within 5 days of needle stick, repeat in 30 days; 100u IM within 24hr birth to baby of hep B carrier. o Immunoglobin, antilymphocyte (thymocyte). Horse(aAtgam): 10-15mg/kg daily for 3-5 days IV over 4hr; occasionally up to 30mg/kg daily. Rabbit (ATG-Fresenius): 2.5-5mg/kg daily over 4-6hr

IV. o Immunoglobin, normal, human . Hypogammaglobulinaemia: 10-15ml/kg of 6% soltn (600-900mg/kg) IV over 5-8hr, then 5-7.5ml/kg (300-450mg/kg) over 3-4hr monthly; or 0.6ml/kg of 16%

soltn (100mg/kg0 every 2-4wk IM. Sepsis: 0.5g/kg IV over 4hr. Kawasaki, Gillain-Barre, ITP, myasth gravis, stiil's dis: 35ml/kg of 6% soltn (2g/kg) IV over 16hr stat, then if required 15 ml/kg ( 900mg/kg) IV over 8hr each month. Prevention hep A ; 0.1ml/kg (16mg/kg) IM. Prevention measles; 0.2ml/kg (32mg/kg) IM (repeat next day if immunocompropomised).

o Immunoglobulin, rabies (hyperab, Imogam). 20iu (0.133ml)/kg IM once (half infiltrated around wound), with rabies vaccine. o Immunoglobulin, Rh. 1ml (625iu, 125mcg) IM within 72hr of exposure. Large transfusion: 0.16ml(100iu, 20mcg) per ml RH positive red cells ( maternal serum should be anti - D positives 24-

48hr after injection). o Immunoglobulin, tetanus (TIG), IM preparation; 250-500iu ( 1-2amp). IV preparation; 4000iu (100ml) at 0.04ml/kg/min for 30min, then 0.075ml/kg/min. o Immunoglobulin, zoster. Prevention of chickenpox in immunocompropomised, 0.4-1.2ml/kg (max 6ml) IM. o Indapamide.0.03-0.05mg/kg (adult 1.5-2.5mg) daily oral. o Indinavir. 500mg/m2/dose (adult 800mg) 8H oral. o Indocyanine green. 0.1mg/kg (adult 5mg) IV. o Indomethacin. 0.5-1mg/kg/dose (adult 25-50mg) 8H (max 6H) oral or PR. PDA: 0,1mg/kg (<1kg) or 0.2mg/kg(>+1kg) day 1, then 0.1mg/kg daily days 2-7 oral or IV over 1hr. o Indoramin. 0,5-1.5mg/kg/dose (adult 25-75mg) 8-12h oral. o Infliximab. 3mg/kg (arthritis, with methotrexate) 5mg/kg (Crohn;s) IV over 2hr, then (if response) after 2wk, 6wk, and then 5-10mg/kg every 8wk. o Influenza A and B vaccine (Fluvax, Vaxigrip). Inactivated. 0.125ml (3mo-2yr), 0.25ml (2-6yr), 0.5ml (>6yr) SC stat and 4wk later ( 2 doses). Boost annually (1 dose).

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o Inosine pranobex. Herpes: 20mg/kg/dose (adult 1g) 6-8H oral. SSPE: 10-15mg/kg/dose 4H oral. o Inositol nicotinate. 20mg/kg/dose (adult 1g) 6-8H oral. o Insulin. Regular insulin: 0.05-0.2u/kg prn, or 0.05-0.1u/kg/hr (5u/kg in 50ml at 0.5-1ml/hr); later 1u/10g dextrose IV. For hyperkalaemia; 0.1u/kg insulin and 2ml/kg 50% dextrose IV. In TPN; 5-

25u/250g dextrose.SC insulin( onset/peak/duration): lispro 10-15min/1hr/2-5hr; aspart 15-20min/1hr/3-5hr; regular 30-60min/4hr/6-8hr; isophane (NPH)2-4hr/4-12hr/18-24hr; zinc (Lente) 2-3hr/7-15hr/24hr; glargine 1.5hr/none/24hr; crystalline zinc (Ultralente) 4-6hr/10-30hr/24-36hr; protamine zinc 4-8hr/15-20hr/24-36hr.

o Interferon alfa-2a, recombinant. Haemangioma: 1million u/m2 daily SC or IM incr over 4wk to 2-3 million u/m2 daily for 16-24wk, then x3/wk. Hep B, C: 3-6million u/m2 x3/wk SC or IM for 4-6mo; higher doses may be reqd in hep B.

o Interferon alfa-2b, recombinant. Condylomata: 1million unit into each lesion (max 5) x3/wk for 5wk, Haemangioma; as for interferon alfa-2a, hepatitis B, C; monotheraphy as for interferon alfa 2a; hep C refractory to interferon monotherapy (adult, NOT/kg): 3million unit x3/wk Imor SC, plus ribarivin oral 400mg morning and 600mg evening (<75kg), or 600mg morning end evening(>75kg).

o Interferon alfa-2b, pegylated. Hepatitis C: 0.5-1mcg/kg weekly SC for 6mo, plus another 6mo if respond. o Interferon alfa-n3. Warts(NOT/kg):250,000u injected intobase of wart (max 10doses/session) x2/wk for max 8wk. o Interferon alfacon - 1. Hepatitis C (adult , NOT/kg); usually 9mcg (7.5mcg if not tolerated) x3/wk SC for 24wk; if relapse 15mcg x3/wk SC for 6mo. o Interferon beta-1a. Mult scier (adult, NOT/kg): Avonex 30mcg (6million IU) once a wk IM, Rebif 44mcg x3/wk SC. o Interferon beta-1b. Mult scler (adult, NOT/kg): 250mcg (8million UI) SC alternate days. o Interferon gamma -1b Chronic gran dis; 1,5mcg/kg (body area <= 0,5m2) or 50mcg/m2 (area>0.5m2) x3/wk SC. o Interleukin-2. Malignancy; constant IV infsn less toxic than bolus injtn; 3,000,000-5,000,000u/m2/day for 5 days, repeat x 1-2 if tolerated (5 days between courses). o Iodoquinol. See di-iodohydroxyquinoline. o Ipecacuanha syrup (total alkaloids 1.4mg/ml). 1-2ml/kg (adult 30ml) stt oral, NG. may repeat once in 30min. o Ipratropium bromide. Resp soltn (250mcg/ml): 0.25-1ml diluted to 4ml 4-8; severe attack every 20min for 3 doses, then 4-6H.Aerosol 20mcg/puff; 2-4 puffs 6-8H. Nasal; 84mcg/nostril 6-12H. o Irbesartan. 3mg/kg (adult 150mg) daily oral, incr to 6mg/kg (adult 300mg) daily if reqd. o Irinotecan. 350mg/m2 IV over 90min every 3wk; reduce to 250-300mg/m2 every 3wk if toxicity. o Iron.See ferrous gluconate, ferrous sulphate. o Iron dextran, iron polymaltose. Fe 50mg/ml; dose (ML) = 0.05 x Wt in kg x (15- Hb in g%) IM (often in diveded doses). IV infsn possible (but dangerious). o Isoconazole. Topical; 1% cream 12H. Vaginal: 600mg(2 tab) once. o Isoetharine. Inhaltn soltn (1%); 0.5ml diltd to 4ml 3-6H (mild), 1ml diltd to 4ml 1-2H (moderate), undiltd constant (severe, in ICU). Aerosol 340mcg/puff: 1-2 puff 4-6H. o Isometheptene. 2.5mg/kg (max 130mg) stat, then 1.5mg/kg (max 65mg) 1H to max 7mg/kg (max 325mg) in 12hr oral. See also dichloralphenazone. o Isoniasid. 10mg/kg (max 300mg) daily oral, IM or IV. TB meningitis: 15-20mg/kg (max 500mg) daily. o Isoprenaline. Aerosol 80-400mcg/puff: 1-3puffs 4-8. IV infsn<33kg:0.3mg/kg in 50ml at 1ml/hr = 0,1mcg/kg/min;>33kg: 0.1mcg/kg/min using 1/5000(0.2mg/ml) soltn= 0.03 x Wt ml/hr; for

65kg adult 4mg in 50ml at 2ml/hr is 0.05mcg/kg/min. o Isoproterenol. See isoprenaline. o Isosorbide dinitrate. Sublingual: 0.1-2mg/kg/dose (max 10mg) 2H or as needed. Oral; 0.5-1mg/kg/dose (max 40mg) 6H or as needed. Slow release tab, adult(NOT/kg): 20-80mg/dose 12H. IV

infsn 0.6-2mcg/kg/min: child see p.47; for 65kg adult 50mg in 50ml ar 2.5ml/hr is 0.5mcg/kg/min. o Isosorbide mononitrate. Slow release tab, adult (NOT/kg): 60-120mg daily oral. o Isotretinoin. Adult 0.5-1mg/kg daily oral for 2-4wk, reduce if possible top 0.1-0.2mg/kg daily for 15-20wk.0.05% gel: apply sparingly at night. o Isoxsuprine. 0.2-0.5mg/kg/dose (adult 10-20mg) 6-12H oral. o Ispaghula husk. Adult (NOT/kg): 1-2 teaspoonfuls 6-12H oral. Half this dose 6-12yr. o Isradipine.0.05mg/kg/dose 12H oral, may incr after 2-4wk gradually to 0.1-0.2mg/kg/dose (max 10mg) 12H. o Itraconazole. 2-4mg/kg/dose (adult 100-200mg) 12-24H cral after food. Trough level>0.5mcg/ml at 10-14 days. o Ivermectin. 0.15-0.4mg/kg (adult 12-24mg) oral every 6-12mo.

27

J o Japanese encephalitis vaccine ( Je-Vax). Inactivated. 0.5ml (1-3yr), 1ml (>3yr) SC stat, 7-14 days later, and ( optionally) 1mo later. Boost after 1yr.

K o Kanamycin. Single daily dose IV or IM. Neonate: 15mg/kg stat,then 7.5mg/kg (<30wk) 10mg/kg (30-35wk) 15mg/kg (term <1wk) daily 1wk-10yr; 25mg/kg day 1. then 18mg/kg daily. > 10yr;

20mg/kd day 1,then 15mg/kg (max 1.5g) daily. Trough level <5.0mg/L. o Ketamine. Sedation, analgesia; 2-4mg/kg IM, 4mcg/kg/min IV. Anaesthesia: 5-10mg/kg IM, 1-2mg/kg IV, ifsn 10-40mcg/kg/min. Premed: 5mg/kg oral. o Ketoconazole. Oral; 5mg/kg/dose (adult 200mg) 12-24H 2% cream; apply 12-24H. 2% shampoo; wash hair, apply liquid for 5min, wash off. o Ketoprofen. 1-2mg/kg/dose (adult 50-100mg) 6-12H (max 4mg/kg or 200mg in 24hr) oral, IM, PR. Slow release, adults (NOT/kg):200mg daily. o Ketorolac. Oral, 0.2mg/kg/dose (max 10mg) 4-6H (max 0.8mg/kg/day or 40mg/day). IM; 0.6mg/kg (max 30mg) stat, then 0.2-0.4mg/kg/dose (max 20mg) 4-6H for 5 days, then 0,2mg/kg/dose

(max 10mg) 6H. o Ketotifen. Child >2yr (NOT/kg): 1mg/dose 12H oral with food. Adult (NOT/kg): 1-2mg/dose 12H oral with food.

L o Labetalol. 1-2mg/kg/dose (adult 50-100mg) 12H oral, may incr wkly to max 10mg/kg/dose (max 600mg) 6H. o Lacidipine. 0.04-0.12mg/kg (adult 2-6mg) daily oral. o Lactase. See tilactase. o Lactulose. 3.3g/5ml soltn. Laxative: 0.5ml/kg/dose 12-24H oral. Hepatic coma: 1ml/kg/dose hourly until bowel cleared., then 6-8H. o Lamivudine. 4mg/kg/dose (adult 150mg) 12H. oral. Hepatitis b: 2mg/kg daily. o Lamotrigine. 0.2mg/kg (adult 25mg) oral deaily, incr slowly if reqd to max 1-4mg/kg/dose (adult 50-200mg) 12H. Double dose if taking carbamazepine, phenobarbitone, phenytoin or

primidone; halve dose if taking valporate. o Lanreotide. 0.5-1.0mg/kg (adult 30mg) IM every 2wk (adjust dose and frequency according to response). o Lansoprazole. 1.5mg/kg (max 30mg) 12-24H oral. o L- asparaginase. See colaspase. o Latanoprost. 50mcg/ml: 1drop/eye daily. o Latanoprost + timolol. 1.5mcg/150mcg per drop. 1drop per eye daily. o Laureth-9 . Spider veins. Inject 0.1-0.2ml of 0.5% (10mg/2ml). small varices: 0.1-0.3ml of 1% ( 20mg/2ml). Medium vari9ces: 0.5-1ml of 3% (60mg/2ml). Max 2mg/kg/day. o Leflunomide. Adult (NOT/kg): 100mg daily x3, then 20mg daily oral. o Lenograstim (rHuG - CSF, Granocyte).150mcg/m2 daily SC or IV over 30min. Keep WCC 5,000 - 10,000/mm3. o Lepirudin. 0.4mg/kg IV stat, then 0.15mg/kg/hr (adjusted by APTT) for 2-10 days. o Lercanidipine. 0.2mg/kg (adult 10mg) daily oral, incr to 0.4mg/kg (adult 20mg) daily if reqd. o Letrozole. Adult (NOT/kg): 2.5mg daily oral. o Leucovorin. See folinic acid. o Leuprolide. See leuprorelin. o Leiprorelin (GnRH or LHRH), adult (NOT/kg): 7.5mg depot injection monthly IM. o Levalbuterol. See salbutamol.

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o Levamisole. Anthelmintic: 3mg/kg (adult 150mg) oral once (ascaris), repeat in 1wk (hookworm). Adenocarcinoma colon (with 5- fluorouracil 450mg/m2 IV wkly): 1mg/kg (adult 50mg) 8H ral for 3 days every 2wk.

o Levetiracetam. 10mg/kg/dose (adult 500mg) 12H oral, incr every 2-4wk to max 30mg/kg (adult 1500mg) 12H if reqd. o Levobetaxolol. 0.5% soltn: 1drop/eye 12H. o Levobunolol. 0.25%-0.5% soltn: 1drop/eye 12-24H. o Levobupivacaine. See bupivacaine. o Levocabastine. 0.5mg/ml : 1drop/eye 6-12H max 8wk, 2 srays/nostril 6-12H max 8wk. o Levocarnitine. See carnitine. o Levodopa + benserazide (4:1) Adult (NOT/kg): initially levodopa 100mg/dose 8H oral; if not controled, incr wkly by 100mg/day to max 250mg/dose 6H. o Levodopa + carbidopa. 250mg/25mg and 100mg/10mg tabs. Adult (NOT/kg); initially one 100/10tab 8H oral; if not contolled, substitute one 250/25 tab for one 100/25 tab every 2nd day; if

not controlled on 250/25 8H, incr by one 250/25 tab every 2nd day to max 6-8 tab/day. o Levofloxacin. 5-10mg/kg/dose (dault 250-500mg) 12-24H oral or IV over 1hr. o Levomethadil acetate. Adult (NOT/kg): usual starting dose 20-40mg every 2-3 days oral. o Levonorgestrel. Contraception: 30mcg daily oral, starting 1st day menstruation. Intrauterine T-system 52mg; insert within 7 days of start of menstruation, replace after 3yr, post-coital; 0.75mg

oral within 72hr, repeated after 12hr, or 0.5mg + ethyniloestradiol 100mcg oral within 72hr, repeated after 12hr. o Levonogestrel + ethyniloestradiol ( 150mcg/30mcg or 125mcg/5Cmcg) x21 tab + 7 inert tab. Contraception: 1 tab daily, starting 1st day of menstruation. o Levorphanol. 0.03-0.1mg/kg/dose 12-24H oral or SC. o Levothyroxine sodium. See thyroxine. o Lidocaine. See lignocaine. o Lignocaine. IV 1mg/kg ( 0.1ml/kg of 1%) over 2min, then 15-50mcg/kg/min. VF: 1mg/kg (0,1ml/kg of 1%) IV. Nerve block; without adrenaline max 4mg/kg (0.4ml/kg of 1%), with adrenaline

7mg/kg (0.7ml/kg of 1%). Topical spray; max 3-4mg/kg (Xylocaine 10% spray pack; about 10mg/puff). Topical 2% gel, 2.5% compound mouth paint/gel (SM-33). 2% and 4% soltn, 5% ointment, 1% dental ointment: apply 3H pm.

o Lignocaine 2.5% + prilocaine 2.5%. cream (EMLA); 1,5g/10cm2 under acclusive dressing for 1-3hr. o Lincomycin. 10mg/kg/dose (adult 600mg) 8H oral, IM or IV over 1hr. severe inftn; 15-20mg/kg/dose (adult 1.2g) IV over 2hr 6H. o Lindane. 1% cream. Lotion. Scabies; apply from neck down, wash off after 8-12hr. lice; rub into hair for 4min, then wash off; repeat after 24hr (max x2/wk). o Linezolid. 10mg/kg/dose 8-12H (child) or 400-600mg 12H (adult), IV over 1-2hr or oral. o Linoleic acid. See fatty acids. o Liothyronine sodium (T3). Oral; 0.2mcg/kg/dose (adult 10mcg) 8H, may incr to 0.4mcg/kg/dose (adult 5-20mcg) 8-12H. Septic shock: 0.1-0.2mcg/kg/hr (adulrtt 100-200mcg/day) IV infsn. o Loitrix. Liothyronine (T3) plus thyroxine (T4) mixture. o Lipase, lipolytic enzymes. See pancreatic enzymes. o Lipid. 20% emulsion: 1-3g/kg/day IV ( ml/hr = g/kg/day x wt x 0.21). o Lisinopril. 0.1mg/kg (adult 5mg) daily oral, may incr over 4-6wk to 0.2-1mg/kg (adult 10-20mg) daily. o Lithium (salts).5-20mg/kg/dose 8-24H oral. Slow release tab 450mg (adult, NOT/kg): 1-2 tab 12H. Maintain trough level 0.8-1.6mmol/L (> 2mmol/L toxic). o Lodoxamide. 0.1% soltn: 1-2 drop/eye 6H. o Lofepramide. Adult (NOT/kg): 70mg morning, 70-140mg night oral. o Lofexidine. 2-8mcg/kg/dose (adult 100-400mcg) 6-12H oral. o Lomefloxacin. 8mg/kg (adult 400mg) daily oral. o Lomustine (CCNU). 100-130mg/m2 oral every 6wk. o Loperamide. 0.05-0.1mg/kg/dose (adult 2-4mg) 8-12H oral incr if reqd to max 0.4mg/kg/dose (max 4mg) 8H. o Lopinavir 133.3mg + ritonavir 33.3mg.>2yr: 230/57.5mg/m2/dose (max 400/100mg) 12H oral; with nevirapine or efavirens 300/75mg/m2/dose (max 533/133mg) 12H.

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o Loracarbef. 4-8mg/kg (adult 200-400mg) 12H oral. o Loratadine. 0.2mg/kg (adult 10mg) daily oral. o Lorazepam. 0.02-0.06mg/kg/dose (adult 1-3mg) 8-24H oral. IV: 0.05-0.2mg/kg IV over 2min, then 0.01-0.1mg/kg/hr. o Losartan. 0.5-2mg/kg (adult 25-100mg) daily oral. o Lovastatin. 0.4-0.8mg/kg/dose (adult 20-40mg) 12-24H oral. o Loxapine. 0.2-1mg/kg/dose (adult 10-60mg) 6-12H oral, IM. o Lyme disease vaccine. Recombinant OspA. 30mcg in 0.5ml IM at 0.1 and 12mo. o Lymecycline. 408mg = 300mg tetracylline base. Adult (NOT/kg): 408mg 12H oral. o Lymphocyte Immune globulin. See immunoglobulin, lymphocyte immune. o Lypressin (lysine-8-vasopressin). 1 spray (2.5iu) into 1 nostril 4-8H, may incr to 1 spray both noctris 4-8H. o Lysuride. Migraine: 0.5mcg/kg/dose (adult 25mcg) 8H oral. Parkinson's, adults (NOT/kg): 0.2mg daily, incr by 0.2mg daily each wk to max 1.6mg/dose 8H oral.

M o Macrogol solutions. See colonic lavage soltn. o Mafenide acetate. 8.5% cream ; apply 2mm layer 12-24H. 5% soltn ; apply 4-8H to keep dressings wet. o Magnesium chloride 10%. .0.48g/5ml = Mg 1mmol/ml. 0.4ml/kg/dose 12H slow IV. Myoc infract (NOT/kg): 5ml/hr IV for 6hr, then 1ml/hr for 24-48hr. VF; 0.1-0.2ml/kg IV. o Magnesium hydroxide. Antacid: 10-40mg/kg/dose (max 2g) 6H oral. Laxative: 50-100mg/kg (max 5g) oral. o Magnesium sulphate. Deficiency: 50% mag sulph ( 2mmol/ml) 0.2ml/kg/dose (max 10ml) 12H IM, slow IV, Asthma, digoxin tachycardia, eclampsia, prem labour, pulht: 50% 0.1ml/kg (50mg/kg)

IV over 20min, then 0.06ml/kg/hr (30mg/kg/hr); keep serum Mg 1.5-2.5mmol/L (pulht 3-4mmol/L). myoc infarct (NOT/kg); 50% 2.5ml/hr (5mmol/hr) IV for 6hr, then 0.5ml/hr (1mmol/hr) for 24-48hr. VF : 50% 0.05-0.1ml/kg (0.1-0.2mmol/kg) IV. Laxative: 0.5g/kg/dose (max 15g) as 10% soltn 8H for 5 days oral.

o Malathicn. See maldison. o Maldison. 0.5% liquid ; 20ml to hair, wash off after 12hr. o Mannitol. 0.25-0.5g/kg/dose IV ( 2-4ml/kg off 12.5%, 1.25-2.5ml/kg off 20%, 1-2ml/kg of 25%) 2H pm, provided serum osmolality < 320 - 330mmol/L. o Maprotiline. 0.15-1mg/kg/dose (adult 10-50mg) 8-24H oral. o Marimastat. Adult (NOT/kg): 5-25mg/dose (usually 10mg) 12H oral. o Mazindol.Adult (NOT/kg): 0.5mg daily oral. May incr to 1-3mg daily. o Measles vaccine (Attenuvax). Live >12mo: 0.5ml SC once. o Measles + mumps + rubella vaccine ( MMRll, Priorix), Live >12mo: 0.5ml SC. o Measles + mumps vaccine ( Rimparix). Live. >12mo: 0.5ml Sc once. o Mebendazole.NOT/kg: 100mg/dose 12H x3 days. Enterobiasis (NOT/kg): 100mg once, may repeat after 2-4wks. o Mebeverine. 135mg tab: adult (NOT/kg): 1-3 tab daily oral. o Mebhydrolin. 1-2mg/kg/dose (adult 50-100mg) 8-12H oral. o Mecamylamine. 0.05mg/kg/dose (adult 2.5mg) 12H oral; may incr to max 0.5mg/kg/dose (adult 25mg) 6H oral. o Mechlorethamine. See mustine HCI. o Meclizine. See meclozine. o Meclofenamate. 1-2mg/kg/dose (adult 50-100mg) 6-8H oral. o Meclozine. 0.5-1mg/kg/dose (adult 25-50mg) 12-24H oral. o Medroxyprogesterone.Adult (NOT/kg): 5mg daily for 5-10 days per month oral; precocious puberty 5-10mg daily ; to achieve amenorrhoea 10-20mg daily ; malignancy 0.5g daily IM or oral for

4wk, then 1g wkly. Depot contraceptive (adult, NOT/kg): 150mg deep IM every 3 months (13wk).

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o Medroxyprogesterone (MP) + conjugated oestrogens (CO). MP (NOT/kg); 10mg (up to 20mg) daily oral for last 10-14 days of 28 day cycle. CO (NOT/kg): 0.625mg (0.3-1.25mg) daily continuosly.

o Medrysone. 1% soltn ; drop/eye 6-12H. o Mefenamid acid. 10mg/kg/dose (adult500mg) 8H oral. o Mefloquine. 15mg/kg (adult 750mg) stat, then 10mg/kg (adult 500mg) after 6-8hr. Prophylaxis: 5mg/kg (adult 250mg) once a wk. o Mefruside.0.5-1mg/kg (up to 2mg/kg for 3 days) daily 10-14 days, then 0.5-1mg/kg (adult 25-50mg) every 2-3 days. o Megestrol acetate. NOT/kg: 80mg per dose 12H oral. o Meglumine antimonate. Soltn 85mg/ml of pentavalent antimony. Same dose as sodium stibogluconate, deep IM. o Melatonin. Usually 0.1mg/kg (adult 6mg) at night oral. o Meloxicam.0.15-0.3mg/kg (adult 7.5-15mg) daily oral, PR. o Melphalan. Usually 6mg/m2 daily x5, repeat every 6wk. o Menadione, menadiol. See menaphthone sod bisulphate. o Menapthone sodium bisulphite ( vitamin K3). NOT/kg:5-10mg x1-2/wk (infant) 10mg daily (child) 10mg/dose 8H (adult) oral. Mitochondrial dis (all ages, not/kg): 10mg/dose 6H oral. o Meningococcus gp A, C, W135 and Y vaccine ( Mencevax ACWY, Menomune). Inactivated. > 2yr: 0.5ml SC. Boost 1-3yrly. o Meningococcus gp C, conjugate vaccine (Meningitec, Menjugate, Neis Vac-C). Inactivated. 0.5ml IM: 3 doses at least 1mo apart ( 6wk-6mo), 2 doses (6-12mo), 1 dose (>12mo). o Menopausal gonadotrophin. See menotropin. o Menotrophin (FSH + LH acyivity). Females (NOT/kg): 75+75iu or 150+150iu IM daily for 9-12 days until oestrogen levels rise, then give HCG. Males (NOT/kg): 75+75iu IM x2-3/wk with HCG

7000iu IM x2/wk. o Meperidine.See pethidine. o Mephenytolin.See methoin. o Mephobarbital. See methylphenobarbitone. o Mepivacaine.Max dose 5-7mg/kg. o Meprobamate. 5-10mg/kg/dose (max800mg) 8-12H oral. o Meptazinol. 4mg/kg/dose (adult 200mg) 3-6H oral. o Mepyramine.2-4mg/kg/dose (adult 100-200mg) 8H oral. o Mequitazine. 0.1mg/kg/dose (adult 5mg) 12H oral. o Mercaptopurine (6MP). 75-100mg/m2 daily oral. o Meropenem. 1020mg/kg/dose (adult 0.5-1g) 8H IV over 5-30min. Severe inftn: 20-40mg/kg/dose (adult 1-2g) 12H (1st wk life) 8H (>1wk) or constant infsn. o Mesalamine. See mesalazine. o Mesalazine. Mesasal, salofalk: 15-20mg/kg/dose (adult 500mg) 8H, reducing to 10mg/kg/dose (adult 250mg) 8H oral. High initial dose, lower maintenance (adult, NOT/kg): 0.4-6g 8H (Asacol,

Coltec); 0.5-1g 6H (Pentasa, ethylcellulose coat) 0.5-1g 6H oral. Suppos: 0.5-1g 8H. Enema: 1-4g nocte. o Mesna.IV over 30min: 20% of the cyclophosphamide or ifosfamide dose at 0.4 and 6hr. oral: 40% of the cytotoxic dose at 2,2 and 6hr. Nebuliser: 0.6-1,2g/dose (NOT/kg);4-6H. o Mesoridazine. Oral: 0.25-3mg/kg/dose (adult 25-150mg) 8H. IM: 0.5mg/kg/dose (adult 25mg, max 200mg/day). o Mesterolone.0.5mg/kg/dose (adult 25mg) 6-12H oral. o Mestranol.See norethisterone. o Metaproterenol. See orciprenaline. o Metaraminol. Adult (NOT/kg):initially 500mg 8-24H oral, max 1g per dose 8H. See also glibenclamide. o Methacycline. NOT/kg: 150mg (>8yr) 300mg (adult) 12H oral. o Methadone. Usually 0.1-0.2mg/kg/dose (adult 5-10mg) 6-12H oral, SC or IM. o Methamphetamine.See methylamphetamine.

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o Methazolamide. 1-2mg/kg/dose (adult 50-100mg) 8-12H oral. o Methdilazine. 0.1-0.3mg/kg/dose (adul;t 4-16mg) 12-24H oral. o Methenamine hippurate or mandelate. See hexamine. o Methenolone. Adult (NOT/kg); Oral: 5-10mg/dose 12H. IM: 100mg every 1-2wk or 200mg every 2-3wk (carcinoma); 50-100mg every 2wk, then every 3-4wk (osteopor). o Methymazole. 0.3-1mg/kg (adult 20-60mg) daily oral, reducing to 0.1-0.5mg/kg (adult 5-30mg) daily. o Methionine. 50mg/kg/dose (max 2,5g) oral 4H for 4 doses prophylaxis: 1mg to paracetamol 5mg. o Methocarbamol. Oral: 30mg/kg/dose (adult 1.5g) 6H for 3 days, then 15-20mg/kg/dose (adult 0.75-1g) 6-8H. IV over 5-10min or IM: 15mg/kg/dose (adult 750mg) 6H. o Methohexital. See methohaxitone. o Methohexitone. 1-2mg/kg/dose (adult 50-120mg) slow IV. o Methoin. 1mg/kg (adult 50mg) daily oral, may incr by 1mg/kg each wk to max 10mg/kg (adult 600mg) daily. o Methotrexate.Leukaemia: typically 3.3mg/m2 IV daily for 4-6wk; then 2.5mg/kg IV every 2wk, or 30mg/m2 oral or IM x2/wk; higher doses with folinic acid rescue. Intrathecal: 12mg/m2 wkly

for 2wk, then monthly. Arthritis: 10-20mg.m2 wkly oral, IV, IM or SC. Adults psoriasis: 0.2-0.5mg/kg wkly oral, IV or IM until response, then reduce. o Methotrimeprazine. 0.25-1mg/kg/dose (adult 12,5-50mg) 6-8H oral, im or IV. o Methoxamine. 0.1-0.4mg/kg (adult 5-20mg) IM, or 0.1-0.2mg/kg (adult 5-10) IV over 5-10min (at least 15min between doses). Nse drop 0.25%; 1-3 drop/nostril 6-12H. o Methoxsalen. Adult (not/kg): 20mg 2hr before UV exposurew 1% lotion: wkly before 1min of UV light. o Methscopolamine. See hyoscine. o Methsuximide.5mg/kg (adult 300mg) daily, may incr to max 10mg/kg/dose (adult 400mg) 8-12H oral. o Methyclothiazide. 0.05-0.2mg/kg (adult 2.5-10mg) daily oral. o Methylcellulose. Constipation: 30-60mg/kg/dose (adult 1.5-3g) with at least 300ml fluid 12H oral. o Methylcysteine. 4mg/kg/dose (adult 200mg) 6-12H oral. o Methyldopa. 3mg/kg/dose (adult 150mg) 8H oral, may incr to max 15mg/kg/dose (adult 750mg). o Methyldopate. 5-20mg/kg/dose (adult 0.25-1g) 6H IV over 1hr. o Methylene blue. 1-2mg/kg/dose (G6PD deficiency 0.4mg/kg). IV, repeated as reqd. Septic shock: 0.5mg/kg over 15min IV, then 0.1-0.25mg/kg/hr. o Methylergometrine. Adult (NOT/kg): 200mcg IM, IV over 5min, or oral; may repeat in 2hr, then 4-6H. o Methylergonovine. See methylergometrine. o Methylphenidate. 0.1mg/kg/dose oral 8am, noon and (occasaionally) 4pm; incr if reqd to max 0.5mg/kg/dose (adult 20mg) Long acting: 20-60mg( 18-54mg in US) in morning. o Methylphenobarbitone. 4-12mg/kg (adult 200-600mg) daily oral. o Methylprednisolone. Asthma: 0.5-1mg/kg/dose 6H oral, IV or IM day 1, 12H day 2, then 1mg/kg daily, reducing to minimum effective dose. Severe croup: 4mg/kg IV stat, then 1mg/kg/dose

8H. Severe sepsis before antibiotics( or within 4hr of 1 st dose) : 30mg/kg IV once. Spinal cord injury (within 8hr): 30mg/kg stat, then 5mg/kg/hr 2 days, Lotion 0.25%: apply sparingly 12-24H . Methylpred 1mg= hydrocortisone 5mg in glococorticoid activy, 0,5mg in mineralocorticoid.

o Methylprednisolone aceponate. 0.1% cream, ointment: apply 12-24H. o Methyltestosterone.NOT/kg: 2.5-12.5mg/day buccal. o Methysergide maleate. 0.02mg/kg/dose (adult 1mg) 12H oral, incr if reqd to max 0.04mg/kg/dose (adult 2mg) 8H for 3-6mo. o Metipranolol. 0.1%, 0.3%, adult 1 drop/eye 12H. o Metirosine.5-20mg/kg/dose (adult 0.25-1g) 6H oral. o Metoclopramide.0.15-0.3mg/kg/dose (adult 10-15mg) 6H IV, IM or oral; 0.2-0.4mg/kg/dose (adult 10-20mg) 8H PR, perioperative: 0.5mg/lg IV. With chemoter : up to 1-2mg/kg 4H IV. o Metocurine iodide. ICU : 0.4mg/kg IV pm. Theatre: 0.1-0.4mg/kg stat, then 0.01-0.02mg/kg/dose. o Metolazone. 0.1-0.2mg/kg (adult 5-10mg) daily oral. Up to 0.5mg/kg (adult 30mg) daily short term. o Metoprolol. IV, 0.1mg/kg (adult 5mg) over 5min, repeat every 5min to max 3 doses, then 1-5mcg/kg/min. Oral: 1-2mg/kg/dose (adult 50-100mg) 6-12H.

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o Metronidazole. 15mg/kg (max 1g) stat, then 7.5mg/kg/dose (max 1g) 12H in neonate (1st maintanance dose 48hr after load if <2kg, 24hr in term baby), 8H (4+wk) IV< PR or oral. Giardiasis: 30mg/kg (adult 2g) daily x3 oral. Amoebiasis: 40mg/kg/dose (adult 2,4g) 8H x5 days oral. Topical gel 0.5%: apply daily. Level 60-300umol/ml ( x0.17mcg/ml).

o Metyrapone. Diagnosis: 15mg/kg/dose (minimum 250mg) 4H x6 dose oral. Cushing: 1-20mg/kg/dose (max 1g) 4H. o Metyrosine. See metirosine. o Mexiletine. IV infsn: 2-5mg/kg (max 250mg) over 15min, then 5-20mcg/kg/min (max 250mg/hr). Oral: 8mg/kg (max 400mg) stat, then 4-8mg/kg/dose (max 400mg) 8H starting 2hr after

loading dose. o Mianserin. 0.2-0.5mg/kg/dose (adult 10-40mg) 8H oral. o Miconazole. 7.5-15mg/kg/dose (adult 0.6-1.2g) 8H IV over 1hr, Topical: 2% cream powder, lotion, tincture or gel 12-24H. Vaginal: 2% cream or 100mg ovule daily x7. o Microlax enema. <12mo 1.25ml, 1-2yr 2.5, >2yr 5ml. o Midazolam. Sedation: usually 0.1-0.2mg/kg (adult 5mg) IV or IM, up to 0.5mg/kg used safety in children; 0.2mg/kg (repeated in 10min if reqd) nasal; 0.5mg/kg (max 20mg) oral. Infusion

(ventild) 3mg/kg in 50ml at 1-4ml/hr (1-4mcg/kg/min): fitting usually 2-4ml/hr ( range 1-18ml/hr); sedatn 1ml/hr + clonidine 0.5-2mcg/kg/hr. o Midodrine. Adult (NOT/kg): 10mg (max 20mg) 4H (max 3H) on arising, noon, and late afternoon (not after 6pm) oral. o Mifepristone. Termination (NOT/kg): 200-600mg oral once, then if abortion incomplete gemeprost 1mg PV or misoprostol 400mcg oral of misoprostol 800mcg PV in 48hr. o Miglitol. Adult (NOT/kg): 25mg 8-24H incr over 3-6mo to usual maintenance dose of 50mg (max 100mg) 8H oral. o Milrinone.50mcg/kg IV over 10min, then 0.25-0.75mcg/kg/min (max 1.13mg/kg/day). o Mineral mixture (Aminogram). <5.5kg: 1.5g/kg daily oral, mixed with feed. >5.5kg: 8g daily (NOT/kg). o Mineral oil. See prafin liquid. o Minocycline. Over 8yr: 4mg/kg 9max 200mg) stat, then 2mg/kg/dose (max 100mg) 12H oral or IV over 1hr. o Minoxidil. 0.1mg/kg (max 5mg) daily, incr to max 0.5/kg/dose (max 25mg) 12-24H oral. Male baldness: 2% soltn 1ml 12H to dry scalp. o Mirtazapine. 0.3-1mg/kg (adult 15-60mg) daily oral. o Misoprostol (PGE1 analogue). 5mcg/kg/dose (max 200mcg) 4-6H oral. See also mifepristone. o Mitomycin. 2mg/m2 IV daily x10 days, rep[eat only if leucocytes >3000/mm3 + platelets >75,000. o Mitotane. 10-80mg/kg/dose (adult 0.5-4g) 6H oral. o Mitoxantrone.See mitozantrone. o Mitozantrone. Breast cancer or lymphoma: 10-14mg/m2 IV over 10min every 3wk. Leukaemia: 10-12mg/m2 IV over 10min daily for 3-5 days. o Mivacurlum. 0.15mg/kg stat, then 0.1mg/kg/dose IV. Infsn: 5-15mcg/kg/min. o Mizolastine. Adult (NOT/kg): slow rel tab, 10mg daily oral. o Moclobemide. 2-3mg/kg/dose (adult 50-150mg) 6-12H oral. o Modafinil. 2-4mg/kg/dose (adult 100-200mg) 12H oral. o moexipril. 0.15-0.2mg/kg/dose (adult 7.5-10mg) 8-24H oral. o Molindone. 0.1-1.5mg/kg/dose (adult 50-75mg) 8H oral. o Molgramostim. 5-10mcg/kg daily SC or IV over 6hr. o Mometasone furoate. 0.1% cream or oint: apply daily 50mcg spray: adult 2 sprays/nostril daily. o Motelukast. NOT/kg: 4mg 92-5yr) 5mg (6-14yr) 10mg (>14yr) daily at bedtime, oral. o Moracizine. 4-6mg/kg/dose (adult 200-300mg) 8H oral. o Moricizine. See moracizine. o Moroctogog alfa. Recombinant (rDNA) human factopr 8, see factor 8. o Morphine. Half life 2-4hr. IM: neonate 0.1mg/kg, child 0.2mg/kg. Adult 10-20mg. IV (ventilated): 0.1-0.2mg/kg/dose (adult 5-10mg) infsn of 1mg/kg in 50ml 5%D: ventilated neonate 0.5-

1.5ml/hr (10-30mcg/kg/hr), child or adult 1-3ml/hr (20-60mcg/kg/hr) .Patient controlled: 20mcg/kg boluses ( 1ml of 1mg/kg in 50ml) with 5min lockout time + (in child) 5mcg/kg/hr Oral: double parenteral dose; slow release start with 0.6mg/kg/dose 12H and incr every 48hr if reqd.

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o Morhuate sodium. Adult (NOT/kg): 50-250mg per injtn. o Moxifloxacin. 10mg/kg (adult 400mg) daily oral. o Moxonidine. 4mg/kg/dose (adult 200mg) 8-24H oral. o Mumps vaccine ( Mumpsvax). Live >12mo: 0.5ml SC once. See also measles + mumps + rubella vaccine. o Mupirocin. 2% ointment: apply 8-12H. o Muromonab - CD3 (Orthoclone OKT3). 0.1mg/kg (adult 5mg) daily for 10-14 days IV over 1min. o Mustine HCI ( nitrogen mustard). 0.1mg/kg IV daily for 3-4 days. Hodgkins: 6mg/m2 IV o Mycophenolate mofetil. 600mg/m2/dose 12H oral.

N o Nabumetone. 10-20mg/kg/dose (adult 0.5-1g) 12-24H oral. o Nadolol. 1-5mg/kg (adult 40-240mg) daily oral. o Nadroparin. Venous thrombosis: 90anti-XaU/kg 12H sc Prophylaxis: genrl surgery 2850anti-XaU/kg 24H (start 12hr presurgery) SC, then 55anti-XaU/kg daily. Haemodialysis: 65anti-XaU/kg into

arterial line at start 4hr session. o Nafarelin. Adult (NOT/kg): 200mcg spray to 1 nostril 12H. o Nafcillin. Oral: 15-30,g/kg/dose 6H. Severe inftn (slow IV, IM): 40mg/kg/dose (max 2g) 12H ( 1st wk life), 8H (2nd wk), 6H or constant infsn (>2wk). o Naftifine. 1% cream , gel; apply daily. o Naftidrofuryl. 2-4mg/kg/dose (adult 100-200mg) 8H (oral) or 12H (IM, or IV or IA infsn over 2hr). o Nalbuphine. 0.2-0.5mg/kg/dose (adult 20-30mg) 3-6H SC, IM or IV. Anaesthesia: 0.3-1mg/kg IV over 15min, then 0.2-0.5mg/kg every 30min. o Nalidixic acid. 15mg/kg/dose (adult 1g) 6H oral, reducing to 7.5mg/kg/dose (adult 500mg) 6H after 2wk. o Nalmefene. Opiate intoxication ; 0.007mg/kg IV, and 0.0014mg/kg after 2-5min ( 15min if IM, SC) if reqd, postop sedtn; 0.25mg/kg after 2-5min (max 4 doses). Half life 10hr. o Naloxone. Opiate intoxication ( including newborn): 0.1mg/kg (max 2mg) stat IV, IM, SC or intratracheal, then 0.01mg/kg/hr IV. Postop sedatn: 0.002mg/kg/dose repeat every 2min, then

0.01mg/kg/hr ( 0.2mcg/kg/min0 IV. o Naltrexone. 0.5mg/kg (adult 25mg) stat, then 1mg/kg (adult 50mg) daily oral. o Nandrolone decanoate. Anaemia: 1-4mg/kg (adult 50-200mg) wkly deep IM, Osteoporosis: adult (NOT/kg): 50mg deep every 3wk. o Naphazoline. 0.012-0.1%: 1-2 drop per nostril or eye 3-4H. o Naproxen. 1mg= 1.1mg naproxen sodium. >2yr: 5-10mg/kg/dose (adult 250-500mg) 8-12H oral. Adult (NOT/kg): 500mg/dose 12H PR. o Naratriptan. 0.05mg/kg (adult 2.5mg), repeated once after 4hr if reqd. o Nateglinide. Adult (NOT/kg): 60-120mg/dose 8H oral. o Nebivolol. 0.1mg/kg (adult 5mg) daily oral. o Nedrocomil. Inhltn: 4mg (2 puffs) 6H, reducing to 12H when improved 2% eye drops; 1drop/eye 6-24H. o Nefazodone. 1mg/kg/dose (adult 50mg) 12H oral, incr by 1mg/kg/dose (adult 50mg) each wk to 4-6mg/kg/dose (adult 200-300mg) 12H. Slow release: single daily dose. o Nefopam hydrochloride. Oral 0.5-2mg/kg/dose (adult 30-90mg) 8H. IM: 0.4mg/kg (adult 20mg) stat, may repeat in 6hr. o Neisseria meningitidis vaccine. See meaviningococcal vacc, o Nelfinr. 25-30mg/kg/dose (adult 750mg) 8H oral. o Neomycin. 1g/m2/dose 4-6H oral (max 12g/day). Bladder washout: 40-2000mg/L. o Neostigmine. Reverse relaxants. 0.05-0.07mg./kg/dose (adult 0.5-2.5mg) IV; suggested dilution: neostigmine (2.5mg/ml) 0.5ml + atropine ( 0.6mg/ml) 0.5ml + saline 0.5ml, give 0.1ml/kg IV.

Myasth gravis: 0.2-0.5mg/kg/dose (adult 1-2.5mg) 2-4H IM, SC. o Nesiritide. 2mcg/kg IV, then 0.01mcg/kg/min (range 0.005-0.03mcg/kg/min).

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o Netilmicin. Single daily dose IV or IM. Neonate: 5mg/kg stat, then 2,5mg/kg (<30wk) 3.5mg/kg (30-35wk) 5mg/kg (term< 1wk) daily. 1wk-10yr: 8mg/kg day 1, then 6mg/kg daily. >10yr: 7mg/kg day 1, then 5mg/kg daily (max 240-360mg) daily. Trough level <1.0mg/L.

o Nevirapine. Newborn: 5mg/kg daily 2wk, then as for child 120mg/m2 (adult 200mg) daily for 2wk, then 12H oral. o Nicardipine. 0.4-0.8mg/kg/dose (adult 20-40mg) 8H oral, 1-3mcg/kg/min 9max 20mg/hr) IV. o Niclosamide. 50mg/kg (adult 2g) oral. o Nicotinamide. 4% gel, apply sparingly 12-24H. o Nicorandil. 0.1-0.6mg/kg/dose (adult 5-30mg) 12H oral. o Nicotine inhaler. 10mg cartridges. Adult : usually inhale 6-12 cartridges/day for 3mo, then reduce over 6-8wk. o Nicotine resin chewing gum. NOT/kg: 2-4mg chewed over 30min when inclined to smoke; usually need 16-24mg/day. Max 60mg/day. o Nicotine transdermal patches. Usually 21mg, 14mg, and 7mg per 24hr. Adult : if smoked > 20cig/day apply strongest patch daily 3-4wk, medium patch daily 3-4wk (initial dose if smoked <=

20cig/day), then weakest patch daily 3-4wk. o Nicotinic acid. Hypercholesterolaemia and hypertriglyceridaemia: 5mg/kg/dose (adult 200mg) 8H, gradually incr to 20-30mg/kg/dose (adult 1-2g) 8H oral. o Nicotynil alcohol tartrate. Adult (NOT/kg): 25-50mg/dose 6H, slow release tab 150-300mg/dose 12H oral. o Nicoumalone. 0.2mg/kg (adult 10mg) day, 1, 0.12m/kg (adult 6mg) day 2, then 0.02-0.25mg/kg (adult 1-12mg) daily oral. INR 2-2.5 for prophylaxis, 2-3 for treatment. o Nifedipine. Caps 0.25-0.5mg/kg (adult 10-20mg) 6-8H, tabs 0.5-1mg/kg/dose (adult 20-40mg) 12H oral or sublingual. o Nilutamide. Adult (NOT/kg): 300mg daily oral for 4wk, then 150mg daily. o Nimodipine. 1015mcg/kg/hr (adult 1mg/hr) IV for 2hr, then 10-45mcg/kg/hr (adult 2mg/hr) Adult; 60mg/dose 4H oral. o Nisoldipine. Slow release; 0.2mg/kg (adult 10mg) daily oral, incr to 0.4-0.8mg/kg (adult 20-40mg) daily. o Nitrazepam. Child epilepsy: 0.125-0.5mg/kg/dose 12H oral. Hypnotic (NOT/kg): 2.5-5mg (child) 5-10mg(adult) nocte. o Nitric oxide. 1-40pm (up to 80pm used occasionally). 0.1l/min of 1000pm added to 10l/min gas gives 10pm. [ NO[ = Cylinder [NO] x (1-(patient FiO2/Supply FiO2)).[NO] = Cylinder [NO] x NO

flow / Total flow. o Nitrofurantoin. 1.5mg/kg/dose (adult 50-100mg) 6H oral prophylaxis: 1-2mg/kg (adult 50-100mg) at night. o Nitrofurazone. 0.2% cream, soltn: apply every 1-3 days. o Nitrogen mustard. See mustine HCI. o Nitroglycerine. See glyceryl trinitrate. o Nitroprusside. See sodium nitroprusside. o Nizatidine. 3.5mg/kg/dose ( adult 150mg) 12H oral for max 8wk, then daily. H pylori (adult): 300mg/dose 12-24H. o Nonacog alfa. Recombinant human factor 9, see factor 9. o Nonoxynol-9. 2% (Ortho), 5% (Delfen) cream: 1 applicator for just before intercourse. 12.5% (Delfen) foam: 1 applicatorful <60min before intercourse. o Noradrenaline. IV. Infsn: 0.05-0.5mcg/kg/min. See p. 47. o Norepinheprine. See noradrenaline. o Norethindrone. See norethisterone. o Norethisterone. Contraception: 350mcg daily , starting 1st day of menstruation. Menorrhagia: 10mg 3H until bledding stops, then 5mg 6H for 1wk, then 5mg 8H for 2wk. o Norethisterone + ethyniloestradiol (0.5mg/35mcg or 1mg/35mcg) x 21 tab + 7 inert tab. Contraception: 1 tab daily, starting 1st day of menstruation. o Norethisterone 1mg + mestranol 50mcg. Contraception: 1 tab daily from 5th to 25th day of menstrual cycle. o Norethisterone 1mg + oestradiol 2mg. Adult: 1tab daily. o Notethisterone + oestradiol patches. Adult (NOT/kg): 0mg/4mg (Estraderm 50) patch x2/wk for 2wk, then 30mg/10mg (Estragest 250/50) patch x2/wk for 2wk. o Norfloxacin. 10mg/kg/dose (adult 400mg) 12H oral. o Norgestimate 0.25mg + ethyniloestradiol 0.035mg + 7 inert tab. Contraception: 1 tab daily, starting 1st day of menstruation. o Norgestrel. See levonorgestrel.

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o Normacol granules. 6mo-5yr half teasp 12H, 6-10yr I teasp 12H, >10yr 1teasp 8H. o Nortriptyline. 0.5-1.5mg/kg/dose (adult 25-75mg) 8H oral. o Noxytiolin. 1-2.5% soltn into body cavity 12-24H, left at least 30min. Max daily dose 200mg/kg (max 10g). o NTBC (nitro-trifluoromethilbenzoyl cyclohexanedione). 0.5mg/kg/dose 12H oral. o Nystatin. 500,000u (1 tab) 6-8H NG or oral. Neonates: 100,000u (1ml) 8H, Prophylaxis 50,000u(0.5ml) 12H. Topical: 100,000u/gel, cream or ointment 12H. Vaginal: 100.000u 12-24H.

O o Octocog alfa (recombinant factor 8). See factor 8. o Octoxinol (octoxynol). 1% jelly (Ortho-Gynol): 1 teaspoonful on diaphragm before intercourse. o Octreotide. Diarrhoea: 1mvg/kg/dose (adult 50mcg) 12-24H SC, may incr to 10mcg/kg/dose (adult 250mcg) 8H. IV: 1mcg/kg stat, then 1-5mcg/kg/hr. Cycle; 5mcg/kg/hr IV. Acromegaly

(NOT/kg): 0.05-0.1mg/dose 8-12H SC incr if reqd to max 0.5mg/dose 8H for 4wk, then slow release 20mg (range 10-30mg) every 4wk deep IM. o Oestradiol. NOT/kg: Menopause: transdermal patch 3.8mg, 5.7mg or 7.6mg (release 50, 75 or 100mcg/day) apply every 7 days (add progestogen for 14 days per month if uterus intact).

Iduction puberty: 0.5mg alternate days oral, incr over 2-3yr to 2mg/day (add progestogen for 14 days per month when dose 1.5mg/day or when bleeding occurs). Tall stature: 12mg/day oral unyil bone age> 16yr (add progestogen for 14 days per cycle). Gonadal failure: 2mg/day oral (add progestogen for 14 days per cycle).

o Oestradiol 2mg or 4mg (x12 tab), oestradiol 1mg(x6 tab ), oestradiol 2mg or 4mg + Norethisterone 1mg (x10 tab). 1 tab daily, starting 5th day of menstruation. Vaginal tab 25mcg: 1 tab daily for 2wk, then 1 tab x2/wk, See also norethisterone + oestradiol.

o Oestradiol 2mg (x11 tab), oestradiol 2mg + cyproterone 1mg (x10 tab). 1 tab daily for 21 days (starting 5th day of menstruation), then 7 days with no tablet. o Oestradiol 2mg + norethisterone 1mg. Adult 1 tab daily. o 17-beta-Oestradiol. 2mg vaginal ring, replace every 3mo. o oestriol. Inductn puberty: 0.25mg/day incr to 2mg/day (+ progrestogen 12 dats/cicle) oral. Epiphyseal maturtn: daily, reducing to x2/wk. Patch (Menorest) 37.5 (3.28mg), 50 (4.33mg), 75

(6.75mg), 100 (8.66mg): apply 1 patch x2/wk (adjust dose monthly), with medroxyprogresterone acetate ( if uterus intact) 10mg x 10 days/month. o Oestrogen. See ethyniloestradiol. o Oestrone. Adult (NOT/kg). Menopause: oral 0.625-5mg daily; vaginal 0.1-1mg daily, dectr to 1mg x2-3/wk. Hypogondism: 1.25-7.5mg daily oral. o Ofloxacin. 5mg/kg/dose (adult 200mg) 8-12H, or 10mg/kg/dose (adult 400mg) 12H oral IV over 1hr. 0.3%: 1drop/eye hrly for 2 days (4H overnight), reducing to 3-6H. o OKT3. See muromonab-CD3. o Olanzapine. 0.1-0.2mg/kg (adult 5-10mg) daily oral, incr gradually up to 0.4mg/kg (adult 20mg) daily if reqd. o Olmesartan. 0.4-0.8mg/kg (adult 20-40mg) daily oral. o Olopatadine. 0.1% soltn: 1 drop/eye twice a day. o Olpadronate. 0.5mg/kg daily oral. o Olsalazine. NOT/kg: 250mg/dose 12H, incr to max 500mg/dose 6H oral. Maintenance: 500mg/dose 12H. o Omeprazole. Usually 0.4-0.8mg/kg/dose (adult 20-40mg) 12-24H oral. ZE synd: 1mg/kg/dose (adult 60mg) 12-24H oral, incr up to 3mg/kg (adult 120mg) 8H if reqd. IV: 2mg/kg (max 80mg) stat,

then 1mg/kg (max 40mg) 8-12H. H.pylory: 0.8mg/kg/dose (adult 40mg) daily oral with metronidazole 8mg/kg/dose (adult 400mg) 8H + amoxyllin 10mg/kg/dose (adult 500mg) 8H for 2wk. o Ondansetron. IV: prophylaxis 0.15mg/kg (adult 4mg); treatment 0.2mg/kg (adult 8mg) over 5min, or 0.2-0.5mcg/kg/min Cral: 0.1-0.2mg/kg/dose (usual max 8mg) 6-12H. o Oprelvekin. (IL-11). 2mg/m2 (adult 50mcg/kg) SC daily. o Oral rehydratn soltn (ORS). See glucose electrolyte soltn. o Orciprenaline. Oral: 0.25-0.5mg/kg/dose (adult 20mg) 6H Resp soltn (2%): 0.5ml/dose diltd to 4ml 3-6H (mild), 1ml/dose diltd to 4ml (moderate), untilited continously (severe, in ICU). Aerosol

750mcg/dose: 2puffs 4-6H. o Orlistat. 3mg/kg/dose (adult 120mg) with each main meal containing fat (max 3 doses/day). o Ornipressin (POR 8) . IV: 0.1u/kg/hr (max 6u/hr) for max 4hr, then 0.03u/kg/hr (max 1,5u/hr). SC: 5u in 30ml saline, max total dose 0.1u/kg. o Orphenadrine. 1-2mg/kg/dose (adult 50-100mg) 8H oral.

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o Osalazine. Adult (NOT/kg): 500mg 6H oral. o Oseltamivir. Adult (NOT/kg): 75mg 12H for 5 days oral. o Oxacillin. 15-30mg/kg/dose 6H oral, IV, IM Severe inftn: 40mg/kg/dose (max 2g) 12H (1st wk life), 8H ( 2nd wk), 6H or constant infsn (>2wk). o Oxaliplatin. 85mg/m2 every 2wk over 2-6hr IV before 5-FU. o Oxandrolone. 0.1-0.2mg/kg (adult 2.5-20mg) daily oral. Turner's synd: 0.05-0.1mg/kg daily. o Oxaprozin. Usually 20mg/kg (max 1200mg) range 10-26mg/kg (max 1800mg) daily oral. o Oxazepam. 0.2-0.5mg/kg/dose (adult 10-30mg) 6-8H oral. o Oxcarbazepine. 4-5mg/kg/dose (adult 300mg) 12H oral; incr wkly by max 5mg/kg/dose (adult 300mg) to usually 15mg/kg/dose (adult 750mg) max 25mg/kg/dose adult 1200mg). o Oxerutin. 10mg/kg/dose (adult 500mg) 12H oral. o Oxethazine. 10mg/5ml (with Al hydrox + Mg hydrox) adult (NOT/\kg): 5-10ml/dose 6-8H oral. o Oxlconazole. 1% cream, lotion: apply 12-24H. o Oxitropium. Inhaltn: 200mcg/dose (NOT/kg): 8-12H. o Oxpentifilline. Adult (NOT/kg): slow release tab 400mg 8-12H oral. o Oxprenolol. 0.5-2mg/kg/dose (adult 30-120mg) 8-12H oral. o Oxtriphylline. See choline theophyllinate. o Oxybuprocaine. 4mg/ml (0.4%) 1-2drops/eye 8-12H Deep anaes: 2drops/eye every 90sec x3 doses. o Oxybuprocaine 0.4% + fluorescein 0.25%. 1-2 drops/eye. o Oxybutynin, <5yr: 0.2mg/kg/dose 8-12H oral. >5yr (NOT/kg): 2.5-5mg 8-12H oral. Sloe rel: adult 5-30mg daily oral. o Oxycodone. 0.1-0.2mg/kg/dose (adult 5-10mg) 4-6H oral. Incr if reqd Slow release: 0.6-0.9mg/kg/dose (adult 10mg) 12H oral, incr if reqd. Suppos: adult 30mg 6-8H PR. o Oxymetazoline. 0.25mg/ml = 0.025% (<6yr), 0.5mg/ml = 0.05% (>6yr): 2-3 drops or sprays in each nostril 8-12H. o Oxymetholone. 1-2mg/kg (up to 5mg/kg) daily oral. o Oxymorphone. Uually 0.02-0.03mg/kg/dose (adult 1-1.5mg) 4-6H IM or SC Sloe IV: 0.01mg/kg/dose (adult 0.5mg) 4-6H PR: 0.1mg/kg (adult 5mg) 4-6H. o Oxytetracyclline. >8yr (NOT/kg): 250-500mg/dose 6H oral, or 250-500mg/dose 6-12H slow IV. o Oxytocin. Labour (NOT/kg): 1-4U/min IV, may incr to 20mU/min max. Lactation: 1 spray (4iu) into each nostril 5min before infant feeds.

P o Packed cells. 4ml/kg raises Hb 1g%. 1bag is about 300ml. o Paclitaxel. 100-250mg/m2 IV over 24hr each 3wk, total of 3-6 doses. o Palivizumab. 15mg/kg IM once a month. o Pamidronate. Osteoporosis, OI: 3-7mg/kg daily oral. 1.0mg/kg/dose (adult 15-90mg) IV over 4hr daily x3 every 4mo, or once every 3-4wk. hypercalcaemia 20-50mg/m2 (depending on Ca level)

IV over 4hr every 4wk. o Pancreatic enzymes. With meals (NOT/kg): uaually 1-3 Cotayme-S Forte cap, 1-5 Pancrease cap raol. Max lipase 10,000u/kg/day. o Pancuronium. ICU. 0.1-0.15mg/kg IV prn. Theatre: 0.1mg/kg IV, then 0.02mg/kg prn, Infsn: 0.25-0.75mcg/kg/min. o Pantropazole. 1.0mg/kg (adult 40mg) 12-24H oral. IV Gihge, adult: 80mg stat , then 8mg/hr. ZE: 80mg 8-12H adjusted to achieve acid < 10mmol/l. o Papaveretum (20mg/ml) + hyoscine ( 0,4mg/ml). 0.4mg/kg (P) + 0.008mg/kg (H) = 0.02ml/kg/dose IM. o Papaverine. Adult (NOT/kg): 150-300mg 12H oral, 12-40mg x 1-2/wk intracarvernosal. IA lines: 0.12mg/ml. o Para-aminobenzoic acid. See aminobenzoate. o Para-aminohippuric acid. See aminohipuric acid. o Paracetamol. Oral: 20mg/kg stat, then 15mg/kg/dose 4H (max 4g/day); child usual daily max 60mg/kg ( 90mg/kg shotr term). Rectal: 40mg/kg stat, then 30mg/kg/dose 6H (max 5g/day).

Overdose: See acitylcysteine.

37

o Paraffin. Liquid: 1ml/kg (adult 30-45ml) daily oral. Liquid 50% + white soft 50%, ointment: apply 6-12H. o Paraffin 65% + agar. NOT/kg: 6mo-2yr 5ml, 3-5yr 5-10ml, >5yr 10ml 8-24H oral. o Paraffin, phenolphthalein and agar (Agarol). NOT/kg: 6mo-2yr 2,5ml, 3-5yr 2,5-5ml, >5yr 5ml 8-24H oral. o Paraldehyde. IM: 0.2ml/kg (adult 10ml) stat, then 0.1ml/kg/dose 4-6H. IV: 0.2ml/kg (adult 10ml) over 15min, then, 0.02ml/kg/hr (max 1.5ml/hr). Rectal or NG: 0.3ml/kg/dose (adult 5-10ml)

diluted 1:10. o Parathyroid hormone. See teriparatide. o Parecoxib. Adult (NOT/kg): 40mg stat IM or IV, then 20-40mg 6-12H; max 80mg/day. o Paricalcitol. 0.04-0.1mcg/kg x2-3/wk IV during dialysis, incr every 2-4wk if reqd to max 0.24mcg/kg. o Paroxetine. 0.4mg/kg (adult 10mg) daily oral, incr if reqd over 4wk 10 1mg/kg (adult 20-60mg) daily. o Pegademase. 10u/kg IM wkly, incr to 20u/kg wkly. o Pegaspargase. 82.5iu/kg (<0.6m2) or 2500iu/m2 (>0.6m2) IM or IV over 2hr, every 14 days. o Pegfilgrastim. >44kg: 6mg SC once. o Peginterferon alfa - 2b. 0.5-1.0mcg/kg wkly for 6-12mo SC. o Pemoline. >6yr (NOT/kg): 20-120mg daily oral. o Penbutolol. 0.4-1.5mg/kg (adult 20-80mg) daily oral. o Penciclovir. !% cream (10mg/g0 : apply x6/day for 14 days. o Penicillamine (d-penicillamine). Arthritis: 1.5mg/kg/dose (adult 125mg) 12H oral, incr over several monyhs to max 3mg/kg/dose (adult 375mg) 6-8H. Wilson's did, lead poisoning: 5-

7.5mg/kg/dose (adult 250-500mg) 6H oral. Cystinuria: 7.5mg/kg/dose (adult 250-1000mg) 6H oral, titrated to urine cystine <100-200mg day. o Penicillin, benzathine. 1mg= 125u. Usually 25mg/kg (max 900mg) IM once. Venereal disease: 40mg/kg (max 1.8g) IM once,. Strep proph: 25mg/kg (max 800mg) IM 3-4wkly, or 10mg/kg IM

2wkly. o Penicillin, benzathine + procaine. 900mg/300mg in 2ml: 0-2yr half vial, 3yr or more 1 vial IM once. o Penicillin, benzyl (penicillin G, crystalline). 1mg= 1667u. 30mg/kg/dose 6H. Severe inftn: 50mg/kg/dose (max 2g) IV 12H (1st wk life), 6H (2-4wk), 4H or constn infsn (>4 wk). o Penicillin procaine. 1mg = 1000u. 25-50mg/kg (max 1.2-2.4g) 12-24H IM. Single dose: 100mg/kg (max 4.8g). o Penicillin V. See phenoxymethylpenicillin. o Penicilloyl polylysine (Prepen). 0.00006 molar. Scratch: 1 drop. Intradermal: 0.01-0.02ml (NOT/kg). o Pentaerythritol tetranitrate. 0.2-1mg/kg/dose (adult 10-60mg) 6-8H oral. o Pentagastrin. 6mcg/kg SC, or 0.6mcg/kg/hr IV. o Pentamidine Isethionate. 3-4mg/kg ( 1.7-2.3mg/kg base) IV over 2hr or IM daily for 10-14 days ( 1mg base = 1.5mg mesylate = 1.74mg isethionate). Neb: 600mg/6ml daily for 3wk (treatment),

300mg/3ml every 4wk (prophylaxis). o Pentastarch. 10% soltn: 10-40mg/kg IV. o Pentazocine. Oral: 0.5-2.0mg/kg/dose (adult 25-100mg) 3-4H. SC, IM or slow IV: 0.5-1mg/kg/dose (adult 30-60mg) 3-4H. PR: 1mg/kg/dose (adult 50mg) 6-12H. o Pentobarbital. See pentobarbitone. o Pentobarbitone. 0.5-1mg/kg/dose (adult 30-60mg) 6-8H oral, IM, slow IV. Hypnotic: 2-4mg/kg (adult 100-200mg). o Pentosan. 2mg/kg/dose (adult 100mg) 8H oral. o Pentostatin. 4mg/m2 IV wkly. o Pentoxyfilline. See oxpentifilline. o Pentoxyverine. 0.3mg/kg/dose (adult 15mg) 3-6H oral. o Pergolide. Parkinson's: 1mcg/kg (max 50mcg) daily, incr to max 25mcg/kg/dose (max 2mg) 8H oral, Hyperprolactinaemia: 0.5-3mcg/kg daily. o Perhexilline. 2mg/kg (adult 100mg) daily oral; adjust every 2-4wk to max 6-8mg/kg (adult 300-400mg) daily. Maintain plasma level 150-600mcg/l. o Pericyazine. 0.5mg/yr of age ( 1-10yr) 10mg (>10yr) daily oral, incr if reqd to max 1mg/yr ( 1-10yr0 25mg (>10yr) 8H.

38

o Perindropil. 0.05-0.1mg/kg (adult 2-8mg) daily oral. o Permethrin. 1% crème rinse ( head lice): wash hair, apply crème for 10min, wash off; may repeat in 2wk. 5% cream (scabies): wash body, apply to whole body except face, wash off after 12-

24hr. o Perphenazine. 0.1-0.3mg/kg/dose (adult 5-20mg0 8-12H oral. o Pertussis. See diptheria + tetanus + pertussis vaccine. o Pethidine. 0.5-1mg/kg/dose (adult 25-50mg) IV, 0.5-2mg/kg/dose (adult 25-100mg) IM (half life 2-4hr). Infsn: 5mg/kg in 50ml at 1-4ml/hr ( 0.1-0.4mg/kg/hr). PCA 5mg/kg in 50ml: usually bolus

2ml with lockout 5min, optional background 0.5ml/hr. o Phenacimide. 10-20mg/kg/dose (adult 0.5-1g) 8H oral. o Phenazone 5.4% + benzocaine 1.4% (Auralgin). 3 drops per ear 3 times a day for 2-3 days. o Phenazocine. 0.1-0.4mg/kg/dose (adult 5-20mg) 4-6H oral or sublingual. o Phenazopyridine. 4mg/kg/dose (adult 200mg) 6H oral for 2 days. o Phendimetrazine. 0.4-1.4mg/kg/dose (adult 20-70mg) 8H oral. o Phenelzine. 0.3-2mg/kg/dose (adult 15-90mg) 8H oral. o Phenindamine. 0.5-1mg/kg/dose (adult 25-50mg) 8-12H oral. o Phenindione. 2mg/kg (adult 100mg) 12H day 1, 1mg/kg(adult 50mg) 12H day 2, then 0.25-1mg/kg (adult 12.5-50mg) 12H oral. INR for prophylaxis 2-2.5, treatment 2-3. o Pheniramine. 0.5-1mg/kg/dose (adult 25-50mg) 6-8H oral. Slow release tab 75mg at night. o Phenobarbital. See phenobarbitone. o Phenobarbitone. Loading dose in emergency: 20-30mg/kg IM or IV over 30min stat. Ventilated: repeat doses of 10-15mg/kg up to 100mg/kg per day ( beware hypotension). Usual

maintanance: 5mg/kg (adult 300mg) daily IV, IM or pral. Infant colic: 1mg/kg/dose 4-8H oral. Level 80-120umol/L (x0.23=mcg/ml) done Mo-Fr 1100 at RCH. o Phenolphthalein. 0.5-5mg/kg (adult 30-270mg) at night oral. o Phenoperidine. 0.03-0.05mg/kg/dose (adult 1mg) every 40-60min. Ventilated: 0.1-0.15mg/kg/dose (adult 2-5mg) every 40-60min. o Phenoxybenzamine. 0.2-0.5mg/kg (adult 10-40mg) 8-12H oral. Cardiac sugery: 1mg/kg IV over 1hr or oral. o Phenoxymethylpenicillin (penicillin V). 7.5-15mg/kg/dose (adult 250-500mg) 6H oral. Proph: 12.5mg/kg/dose (adult 250mg) 12H oral. o Phentermine. Adult (NOT/kg); 30-40mg daily oral, reducing to 15-40mg daily. o Phentermine resin. Adult (NOT/kg): 30-40mg daily oral, reducing to 15-40mg daily. o Phentolamine. 0.1mg/kg stat, then 5-50mcg/kg/min IV. o Phenylbutazone. Initially 2mg/kg/dose (adult 100mg) 4H, reducing to 1-2mg/kg/dose (adult 50-100mg) 6-8H oral. o Phenylephrine. IV: 2-10mcg/kg stat (adult 500mcg), then 1-5mcg/kg/min (see p.47);65kg adult 25mg in 50ml at 8ml/hr is 1mcg/kg/min. SC or IM: 0.1-0.2mg/kg (max 10mg). Oral:

0.2mg/kg/dose (max 10mg) 6-8H. 0.15%, 10% eye drops: 1-2drops/eye 6-8H. 0.25%, 0.5% nose drops: 1-3 drops/sprays per nostril 6-8H. o Phenyltoloxamine. 1mg/kg/dose (adult 50mg) 8H oral. o Phenytoin. Loading dose in emergency : 15-20mg/kg(max 1.5g) IV over 1 hr.Initial maintenance,oral or IV :2mg/kg/dose 12h (pretem);3mg/kg/dose 12H (1 st wk life),8H (2wk-4yr), 12H (5-

12yr); 2mg/kg/dose (usual max 100mg) 8H > 12yr. Level 40-80 umol/L (x0.25 = mch/ml0, done Mo, We and Fr at RCH. o Pholcodine. 0.1-0.2mg/kg/dose (adult 5-15mg) 6-12H oral. o Phospate, potassium (1mmol/ml). 0.1-1.5mmol/kg/day ( max 70mmol/day) IV infsn. o Phospate, sodium. NOT/kg: 250mg (<4yr) 250-500mg >4yr) 6H oral. o Phospate, sodium (Fleet enema). Na 1.61mEq/l + PO4 4.15 mEq/l + P 1.38mEq/l: 33ml ( 2-5yr), 66ml (5-11yr), 133ml (adult) rectal. o Phospathidylcholine. Usually 60mg/kg ( max 3g) daily oral. o Phosphocysteamine. 10mg/kg/dose 6H oral, incr by 2.5mg/kg/dose every 2wk to 10-20mg/kg/dose 6H so leukocyte half-cysteine <2nmol/mg protein 6hr after dose. o Physostigmine. 0.02mg/kg (max 1mg) IV every 5min until response (max 0.1mg/kg), then 0.5-2.0mcg/kg/min.

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o Phytomenadione (vitamin K1). Deficiency with he: FFP 10ml/kg, yhen 0.3mg/kg (max 10mg), IM or IV over 1hr Prophilaxis in neonates (NOT/kg): 1mg (0.1ml) IM at birth; or 2mg ( 0.2ml) oral at birth, at 3-5 days, and by 4wk ( give half dose if < 1.5kg). Warfarin reversal: 0.1mg/kg (max 5mg) SC or oral (repeat if reqd) ; if severe he 0.3mg/kg (max 10mg) with FFP 10ml/kg. Mitochondrial dis (NOT/kg): 10mg/dose 6H oral.

o Phytonadione. See phytomenadione. o Picibanil ( OK - 432). 1 Klinishe Einheit = 0.1mg. 1mg into tumour 1-2wk preop, then 0.5mg/2wk ID for 1yr postop. o Pilocarpine. 0.1mg/kg/dose (adult 5mg) 4-8H oral. 0.5%, 1%, 2%, 3%, 4% eye drops: 1-2 drops 6-12H. o Pimecrolimus. 1% cream: apply 12H. o Pimozide. 0.04mg/kg (adult 20mg) daily oral, incr if reqd to max 0.4mg/kg (adult 20mg) daily. o Pindolol. 0.3mg/kg/dose (adult 15mg) 8-24H oral. o Pine tar. Gel, solution: 5ml to baby bath, 15-30ml to adult bath; soak for 10min. o Pioglitazone. Adult (NOT/kg); 15-45mg daily oral. o Pipecuronium. 20-85mcg/kg IV stat, then 5-25mcg/kg pm. o Piperacillin. 50mg/kg/dose (adult 2-3g) 6-8H IV. Severe inftn: 75mg/kg/dose (adult 4g) 8H ( 1st wk life0 6h (2-4wk) 4-6H (>4wk) or constant infsn. o Piperazine. 75mg/kg (max 4g) oral daily for 2 dats ( ascaris), 7 days (pinworm). o Piperazine oetrone sulphate. Induction puberty (NOT/kg); 0.156mg daily, incr over 2-3yr to 1.25mg (add progestogen for 12 dats per cycle). o Piperonyl butoxide bloallethrin. Apply enough to wet scalp or body, leave 30min. wash off. o Pipothiazine. Oily injtn: initialliy 0.5mg/kg (adult 25mg), then 1-4mg/kg (adult 50-200mg) every 4wk IM. o Piracetam. 15mg/kg/dose (max 800mg) 8H oral, IM or IV. o Pirbuterol. Oral: 0.2-0.3mg/kg/dose (adult 10-15mg) 6-8H. Inhaltn (NOT/kg); 0.2-0.4mg/dose 4-6H. o Piroxicam. 0.2-0.4mg/kg (adult 10-20mg) daily oral. Gel 5mg/g: apply 1g (3cm) 6-8H for up to 2wk. o Pivampicillin. 15mg/kg/dose (adult 500mg) 8-12H oral. o Pivampicillin 1.25mg + Pivmecillinam 1mg. 10mg/kg per dose (adult 250mg) of pivampicillin 12H oral. o Pivmecillinam. 5-10mg/kg/dose (adult 200-400mg) 6-8H oral. o Pizotifen. NOT/kg: 0.5mg daily oral, incr if reqd to max 0.5mg morning and 1mg at night. o Plague vaccine (CSL). Inactivated. Adult (>11yr): 0.5ml Sc stat, and 1-4wk later ( 2 doses); boost every 6mo. Child: 4wk later, and 1-4wk later ( 3doses); boost every 6mo. o Platelets. 10ml/kg IV stat, then as reqd. 1 unit approx 60ml. o Plicamycin. Testicular tumours: 25-30mcg/kg daily for 8-10 days IV over 6hr, repeat monthly if response. Hypercalcaemia: 25mch/kg daily for 3-4 days, then x1-3/wk. o Pneumococcal vaccine, polysaccharide (Pneumovax 23). Inactivitd. >2yr: 0.5ml SC or IM once. Boost every 5yr. o Pneumococcal vaccine, CRM conjugate (Prevenar). Inactivated. 0.5ml IM. <6mo: 2mo, 3mo, 4mo, 12-15mo ( 4 doses). 6-11mo: 6mo,7mo,12-15mo (3 doses). 12-23mo: 2 doses 2mo apart.

>23mo 1dose. o Podovilox. See podophyllotoxin. o Podophyllotoxin. 0.5% paint: apply 12H for 3 days, then none for 4 days; 4wk course. o Podophyllum. 15%-25% soltn, oint: apply to wart x2/day. o Pollomyelitis vaccine, oral (Sabin). Live. 2 drops oral at 2mo, 4mo and 6mo (3doses). Boost at 5yr, and if going to epidemic area. o Poliomyelitis vaccine, SC (IPOL). Inactivated. 0.5ml SC stat, 8wk later, and 8wk later ( 3 doses). Boost 12mo later, and at school entry. o Poloxalkol. See poloxamer. o Poloxamer. 10% soltn 8H oral; <6mo 10 drops/dose, 6-18mo 15drops/dose, 18mo-3yr 25drops/dose. o Polyethylene glycol. See colonic lavage solution. o Plymixyn B. See bacitracin + neomycin + polymycin. o Plynoxylin. 10% gel: apply 12H.

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o Polygeline. 10-20ml/kg (may be repeated). Half life 2hr. o Polysterene sulphonate. See sodium polystyrene sulph. o Polythiazide. 0.02-0.1mg/kg/dose (adult 1-4mg) daily oral. o Polyvinil alcohol. 1.4%, 3% soltn: 1-2 drops/eye pm. o Poractant alfa (porcine surfactant, Curosurf). Intratracheal: 200mg/kg stat, then up to 4 doses of 100mg/kg 12H if required. o POR 8. See omipressin. o Porlimer. 2mg/kg IV, then 630nm laser light after 40-50hr and 96-120hr; max 3 courses at least 30 days apart. o Potassium. Deficiency: usually 0.3mmol/kg/hr (max 0.4mmol/kg/hr) for 4-6hr IV, then 4mmol/kg/day. Max oral 1mmol/kg/dose (<5yr), 0.5mmol/kg/dose (>5yr). Maintenance 2-

4mmol/kg/day. 1g KCI = 13.3mmol K, 7.5% KCI = 1mmol/ml. o Potassium gualacolsulfonate. 1-3mg/kg/dose (adult 50-160mg) 4-6H oral. o Povidone-iodine. Cream, oint, paint, soltn: apply 6-12H. o Pralidoxine. 25-50mg/kg (adult 1-2g) over 30min, then up to 10mg/kg/hr (adult 12g/day). o Pramipexole. Adult (NOT/kg); 0.125mg 8H incr by 0.125-0.25mg every days to 0.5-1.5mg 8H oral. o Pramoxine. 1% cream. Lotion: apply 6-8H. o Pravastatin. 0.2-0.4mg/kg (adult 10-20mg) at bedtime oral. o Praziquantel. 20mg/kg/dose oral once (tapeworm), 4H x3 doses (schistosomiasis), 8H x6 doses (other flukes), 8H 14 dats (cysticercosis). Prazosin. 5mcg/kg (max 0.25mg) tets dose, then 0.025-

0.1mg/kg/dose (adult 1-5mg) 6-12H oral. o Prednisolone acetate 1% + phenyleprine 0.12%. 1-2 drops per eye 6-12H. o Prednisolone sodium phospate. 0.5% ear/eye drops: 1-3 drops 2-6H. o Prenisone. Action equivalent to prednisolone. o Prilocaine. Max dose 6mg/kg (0.6ml/kg of 1%). With adrenaline max dose 9mg/kg (0.9ml/kg/of 1%). o Primaquine. Usually 0.3mg/kg (adult 15mg0 daily for 14-21 days oral. Gameteocyte: 0.7mg/kg (adult 45mg) once. o Primidone. Initially 2.5mg/kg (adult 125mg) at night, incr if reqd to max 15mg/kg/dose (adult 750mg) 12H oral. Trough level (phenobarbitone) 60-120umol/L. o Probenicid. 25mg/kg (adult 1g) stat, then 10mg/kg/dose (adult 500mg) 6H oral. o Probucol. 10mg/kg/dose (adult 500mg) 12H oral. o Procainamide. IV: 0.4mg/kg/min (adult 20mg/min) for max 25min, then 20-80mcg/kg/min (max 2g/day). Oral: 5-8mg/kg/dose 4H. Level 3-10mcg/ml. o Procaine. Max dose 20mg/kg ( 1ml/kg of 2%). o Procarbazine. 1mg/kg (adult 50mg) daily oral, incr over 4-6 days to 4-6mg/kg (adult 200-300mg) daily until remission, then 1-2mg/kg (adult 50-100mg) daily, Suspend if leucocytes <3000/mm3

or platelets < 80,000/mm3. o Prochlorperazine. 1mg base = approx 1.5mg edisylate, maleate or mesylate. Only use if > 10kg. Oral (salt): 0.2mg/kg/dose (max 35mg) 6H in pstchosis. IM, slow IV (salt): 0.2mg/kg (adult

12.5mg) 8-12H. Buccal(salt): 0.05-0.1mg/kg (max 6mg) 12-24H. PR (base): 0.2mg/kg (adult 25mg) 8-12H. o Procyclidine. 0.05-0.2mg/kg/dose (adult 2.5-10mg) 6-8H oral. o Progesterone. Adult (NOT/kg): Prements syn: 200-400mg/dose PV or PR 12-24H (last half of cycle). Dysf uthge: 5-10mg/day IM for 5-10 days before menses. Prevent abrtn: 25-100mg IM every

2-4 days. o Progestin norelgestromin + ethinyloestradiol. 6mg/0.75mg transdermal patch. Women <90kg: apply 1 patch per wk for 3wk, no patch in wk 4 of cycle. o Proguanil. 3.5mg/kg (adult 200mg) daily oral after food. o Promazine. Oral: 2-4mg/kg/dose (adult 100-200mg) 6H. IM 0.7mg/kg/dose (max 50mg) 6-8H. o Promethazine. Antihist, antiemetic: 0.2-0.5mg/kg/dose (adult 10-25mg) 6-8H IV, IM or oral. Sedative, hypnotic: 0.5-1.5mg/kg/dose (adult 25-100mg). o Proxymetacaine. 0.5%: 1-2 drops/eye before procedure. o Propafenone. Oral: 3-5mg/kg/dose (adult 150-300mg) 8H, IV: 1-2mg/kg over 15min, then 4-8mcg/kg/min.

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o Propamidine. 0.1%: 1-2 drops/eye 6H for up to 2 days. o Propantheline bromide. 0.3-0.6mg/kg/dose (adult 15-30mg) 6H oral. o Propiverine. 0.3mg/kg/dose (adult 15mg) 6-12H oral. o Propofol. Child: 2.5-3.5mg/kg stat, then 7.5-15mg/kg/hr IV. Adult: 1-2.5mg/kg stat, then 3-12mg/kg/hr IV. o Propoxyphene. See dextropropoxyphene. o Propanolol. IV: 0.02mg/kg (adult 1mg) test dose then 0.1mg/kg (adult 5mg) over 10min (repeat x1-3pm), then 0.1-0.3mg/kg/dose (adult 5-15mg) 3H. Oral: 0.2-0.5mg/kg/dose (adult 10-25mg)

6-12H, slow incr to max 1.5mg/kg/dose (max 80mg) 6-12H if required. o Propylthouracil. 50mg/m2/dose 8H oral, reduce according to response. o Proscillaridin. 10-15mcg/kg/dose (adult 500-750mcg) 8-12H oral. o Prostacyllin. See epoprostenol. o Prostaglandin. See alprostadil (PGE 1), carboprost (15-Me-PGF2-alpha), dinoprost (PGF2-alpha), dinoprostone (PGE 2), epoprostenol (PG12, prostacyllin), gemeprost (PGE1 analogue), and

misoprostol (PGE1 analogue). o Protamine. IV 1mg/100u heparin (0.5mg/100u if > 1hr since heparin dose) slow IV stat;subsequent doses of protamine 1mg/kg (max 50mg). 1mg per 25ml pump blood. Heparin 1mg = 100u

(half life 1-2hr). o Protein C, activated. See drotrecogin alfa. o Prothionamide. TB: 15-20mg/kg (adult 0.75-1g) at night oral. Leprosy: 5-8mg/kg (adult 250-375mg) daily. o Prothrombinex. See coagulation factor, human. o Protionamide. See prothionamide. o Protirelin. NOT/kg: 200mcg IV stat. o Protriptyline. 0.1-0.4mg/kg/dose (adult 5-20mg) 6-8H oral. o Proxymetacaine. 0.5% soltn: 1-2 drop/eye stat, then 1 drop every 10min for 5-7 doses. o Pseudoepjhedrine. 1mg/kg/dose (adult 60mg) 6-8H oral. Slow release: adult (NOT/kg) 120mg/dose 12H. o Psyllium. Usually 0.1-0.2g/kg (adult 5-10g) 8-24H oral. o Pumactant (ALEC), Preterm babies (NOT/kg): disconnent ETT, radiply inject 100mg in 1ml saline via catheter at lower end ETT, flush with 2ml air; repeat after 1hr and 24hr. Prophylaxis if

unintubated: 100mg into pharynx. o Pyrantel, Threadworm: 10mg/kg (adult 750mg) once oral, may repeat 2 wkly x3doses. Roundworm. Hookworm: 20mg/kg (adult 1g) once, may repeat in 7 days. Necator: 20mg/kg (adult 1g)

daily x2-3 doses. o Pyrazinamide. 20-35mg/kg (max 1.5g) daily oral, or 75mg/kg (max 3g) x2/wk. o Pyrethrins + piperonyl butoxide. Lice: apply enough shampoo to wet hair, wash off in 15min; repeat in 10 days. o Pyridostigmine. Myas gravis: 5-7mg/kg/dose (usual max 200mg) 4-6H oral. 180mg slow rel tab (Timespan), adult (NOT/kg): 1-3 tab 12-24H. 1mg IV, IM or SC = 30mg oral. o Pyridoxine. Wiyh isoniazid or penicillamine (NOT/kg): 5-10mg daily IV or oral. Fitting: 10-15mg/kg daily IV or oral. Siderobl anaem: 2-8mg/kg (max 400mg) daily IV or oral. o Pyrilamine. See mepyramine. o Pyrimetamine 12.5mg and dapsone 100mg (Maloprim). 1-4yr quarter tab wkly, 5-10yr half tab, >10yr tab. o Pyrimetamine 25mg and sulphadoxine 500mg (fansidar). <4yr half tab once, 4-8yr 1tab, 9-14yr 2 tab, >14yr 3tab. Prophylaxis: <4yr quarter tab wkly, 4-8yr half tab, 9-14yr three-quarter tab,

>14yr 1 tab.

Q o Q fever vaccine (Q-Vax). See Coxiella burneti vaccine. o Quazepam. 0.15-0.6mg/kg (adult 15-30mg) at night oral. o Quetiapine. Adult (NOT/kg): 12H oral per dose: 25mg day 1, 50mg day 2, 100mg day 3,150mg day 4, then 150-250mg/dose (range 75-400mg) 12H.

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o Quinagolide. 0.5mcg/kg (adult 25mcg) nocte, incr to 1.5-3mcg/kg (adult 75-150mcg) nocte oral. o Quinalbarbitone. Sedative 5mg/kg. Premed 10mg/kg. o Quinapril. 0.2-0.8mg/kg (adult 10-40mg) daily oral, see also hydrochlorothiazide. o Qunidine, base. 10mg/kg stat, then 5mg/kg/dose (max 333mg) 4-6H oral. IV: 6.3mg/kg ( 10mg/kg of gluconate) over 2hr, then 0.0125mg/kg/min. IM: 15mg/kg stat, then 7.5mg/kg/dose (max

400mg) 8H. NOTE: 1mg base = 1.2mg sulphate = 1.3mg bisulphate = 1.6mg gluconate. o Quinine, base. Oral: 8.3mg/kg/dose (max 500mg) 8H for 7-10 days. Parental: 16.7mg/kg ( 20mg/kg of dihydrochloride) IV over 4hr or IM, then 8.3mg/kg/dose 8H IV over 2hr or IM for 2-3 days,

then 8.3mg/kg/dose 8H oral for 5 days. NOTE: 1mg base = 1.7mg bisulphate = 1.2mg dihydrochloride = 1.2mg ethyl carbonate = 1.3mg hydrobromide = 1.2mg hydrochloride = 1.2mg sulphate. o Quinupristin 150mg + dalfopristin 350mg (Synercid IV 500mg vial). 7.5mg/kg/dose 8H IV over 1hr.

R o Rabeprazole. 0.4mg/kg (adult 20mg) daily oral. H pylori: 20mg + clarithromycin 0.5g + amoxicyllin 1g all 12H 1wk. o Rabies vaccine, Inactivated (Merieux). 1ml Im stat, 7 days later, and 28 days later (3 doses). Boost every 2yr. Post exposure: if immune, 1ml IM day 0 and day 3; if non immune, give 1ml IM on

days 0.3,7,14,30 and 90, with immunoglobin. o Raloxifene. 1mg/kg (adult 60mg) daily oral. o Raltitrexed. Initially 3mg/m2 IV over 15min every 3wk. o Ramipril. 0.05mg/kg (adult 2.5mg) oral daily, may incr over 4-6wk to 0.1-0.2mg/kg (adult 5-10mg) daily. o Ranitidine. IV: 1mg/kg/dose (adult 50mg) slowly 6-8H, or 2mcg/kg/min. Oral: 2-4mg/kg/dose (adult 150mg) 8-12H, or 300mg (adult) at night. o Ranitidine bismuth citrate. 8mg/kg/dose (adult 400mg) 12H oral, to eradicate H. Pylori, add an antibiotic. o Rapacuronium. Initially 2mg/kg (child), 1.5mg/kg (adult), 2.5mg/kg Caesar); maintenance 33-50% initial. o Razoxane. 2mg/kg/dose (max 125mg) 8-24H oral; or 7.5-15mg/kg (max 750mg) daily for 2-3 days every 1-4wk. Kaposi Sarc, leukaemia: max 0.33g/m2/dose 8H oral. o Reboxetine. Adult (NOT/kg): m2-4mg/dose 12H oral, incr gradually if reqd to max 10mg/dose 12H. o Recombinant antihaemophillic factor. See factor 8. o Remifentanil. 1mcg/kg IV over 30 sec, then 0.05-0.2mcg/kg/min, Ventilated: 1mcg/kg, then 0.5-4mcg/kg/min (up to 8mcg/kg/min if reqd). o Repaglinide. Adult (NOT/kg): before mains meals, oral: initially 0.5mg, incr every 1-2wk to 4mg (max 16mg/day). o Reproterol. Aerosol 0.5mg/puff: 1-2 puffs 3-8H. o Reserpine. 0.005-0.01mg/kg/dose (adult 0.25-0.5mg) 12-24H oral. o Residonrate. Adult (NOT/kg): 5mg daily oral; sloe release 35mg once a week. o Resonium. See sodium polystyrene sulphonate. o Reteplase. Adult (NOT/kg): for myocard infarct: give heparin 5000u IV + aspirin 250-350mg oral; then reteplesa 10U IV over 2min with a second dose 30min later; then heparin 1000u/hr for

24-72hr and aspirin 75-150mg/day until discharge. o Retinol A. See vitamin A. o Reviparin. Child >2mo: 100u/kg 12H SC. Adult (NOT/kg): 1432u 2hr before surgery, then daily SC. o Ribavirin. Inhltn (Viratex nebulizer): 20mg/ml at 25ml/hr (190mcg/l of gas) for 12-18hr/day for 3-7days. Oral: 5-15mg/kg/dose 8-12H . Hepatitis C: see interferon alfa-2b. o Riboflavine. NOT/kg: 5-10mg daily oral. Organic acidosis (NOT/kg): 50-200mg daily oral, IM or IV. o Rifabutin. Pulmonary TB: 3-5mg/kg (adult 150-300mg) daily oral, Resistant pul TB: 5-7.5mg/kg (adult 300-450mg) daily. Mycobact avium complex: 7.5-12mg/kg (adult 450-600mg) daily;

prophylaxis 5mg/kg (adult 300mg) daily. o Rifampicin. 10-15mg/kg (max 600mg) daily oral fasting or, IV over 3hr( monitor AST). Prophylaxis: N. meningitidis 10mg/kg daily (neonate), 10mg/kg (max 600mg) 12H for 2 days; H. influenzae

10mg/kg daily (neonate), 20mg/kg (max 600mg) daily for 4 days. o Rifampin. See rifampicin. o Rifapentine. Usually 10-15mg/kg (adult 600mg) x2/wk for 2mo, then wkly for 4 monyhs.

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o Riluzole. 1mg/kg/dose (adult 50mg) 12H oral. o Rimantadine. 2.5mg/kg/dose 9max 100mg) 12H oral. o Rimexolone. 1%. 1drop/eye 6H. Uvetis: 1 drop 1H in day time for 1wk, 2H for 1wk, 6H for 1wk, daily 1wk. o Risedronate. Osteoporosis: 0.1mg/kg (adult 5mg) daily oral; slow release 0.7mg/kg (adult 35mg) weekly. Paget's: 0.5mg/kg (adult 30mg) daily oral. o Risperidone. 0.02mg/kg/dose (adult 1mg) 12H, incr if reqd to 0.15mg/kg/dose (adult 2-4mg, max 8mg) 12H oral. o Ritrodine. Premature labour (NOT/kg): 0.05-0.45mg/min IV, 10-20mg/dose 4-6H oral. o Ritonavir. 250mg/m2/dose 9adult 300mg) 12H, incr over 5 days if toleratd to 400mg/m2/dose 9adult 600mg) 12h oral. See also lopinavir. o Rituximab. 370mg/m2 by IV infsn wkly x4. o Rivastigmine. Adult (NOT/kg): initially 1.5mg 12H, incr every 2wk to max 6mg 12H oral. o Rizatriptan. Adult (NOT/kg): 10mg oral, repeat x1 after 2hr if reqd. o Rocuronium. 0.6-1.2mg/kg IV stat, then 0.1-0.2mg/kg boluses or 5-15mcg/kg/min. o Rofecoxib. 0.25-0.5mg/kg/dose (adult 12.5-25mg) daily oral. o Ropinirole. Adult (NOT/kg): 0.25mg/dose 8H, incr wkly to 1-8mg/dose 8H oral. o Ropivacaine. 4-5mg/kg (adult max 200-250mg). Postop infusion 0.2-0.4mg/kg/hr (adult 12-20mg/hr). o Rosiglitazone. Adult (NOT/kg): 4mg daily oral, incr after 6-8wk to 4mg 12H if reqd. o Rotavirus. See hyperimmune bovine colustrum, rotavirus. o Roxithromycin. 2.5-4mg/kg/dose (adult 150mg) 12H oral. o Rubella vaccine (Ervevax, meruvax ii) Live. >12mo: 0.5ml SC once. See also measles + mumps + rubella vaccine.

S o Salbutamol. 0.1-0.5mg/kg/dose (adult 2-4mg) 6H oral. Inhaltn: mild resp soltn (5mg/ml, 0.5%) 0.5ml/dose diluted to 4ml, or nebule 2.5mg/2.5ml 3-6H; moderate 0.5% soltn 1ml/dosse diluted

to 4ml, or nebule 5mg/2.5ml 1-2H; severe (in ICU) 0.5% soltn undiluted continous. Aerosol 100mcg/puff: 1-2 puff 4-6H. Rotahaler: 200-400mcg 6-8H. Im or Sc: 10-20mcg/kg/dose (adult 500mcg) 3-6H. IV: child 5-10mcg/kg/min for 1hr, then 1-2mcg/kg/min (1mcg/kg/min using 1mg/ml soltn = 0.06xWt ml/hr).

o Salcatonin. Hypercalcaemia: 5u/kg/dose 12-24H IM, SC or IV over 6-12hr. Paget's: adult 50-100u daily. Cancer bone pain: 4u/kg/dose (adult 200u) up to x4/day. o Salicylic acid. Cradle cap: 6% soltn (Egocappol) 12H 3-5 days. Plantar warts: 15% soltn x1-2/day. 40% medicated disc 24-48H. o Salicylsalicylic acid. See salsalate. o Salmeterol. Aerosol, diskhaler (NOT/kg): 50-100mcg 12H See also fluticasone + salmeterol. o Salmonella typhi vaccine. See typhoid vaccine. o Salsalate. 10-20mg/kg/dose (adult 0.5-1g) 6H oral. o Saquinavir. Adult (NOT/kg): hard gel capsules 600mg 8h oral, soft gel capsules 1200mg 8H oral. o Saracenia purpurea (Sarapin):Adult (NOT/kg): 2-10ml nerve block, 5-10ml local infitration. o Sargramostim (GM-CSF, Leucomax). 3-5mcg/kg daily SC, or IV over 6hr. Keep WCC 5,000-10,000/mm3. o Scopolamine. See hyoscine. o Secbutobarbitone. 0.3-06mg/kg/dose (adult 15-30mg) 6-8H, or 1-4mg/kg (adult 50-200mg) nocte oral. o Secobarbital sodium. See quinalbarbitone. o Secretin. 1cu = 4chr units. 1-2cu/kg slow IV. o Selegiline. Adult (NOT/kg): 10mg each morning, oral. o Selenium sulphide. 2.5% shampoo x2/wk for 2wk. o Sennoside. Tab 7.5mg daily (NOT/kg): 6mo-2yr halh-one tab, 3-10yr 1-2 tab, >10yr 2-4 tab. Granules 22.5mg/teasp, 12-24H (NOT/kg):<6mo quarter-half teasp, 6mo-2yr half-1 teasp, 3-10yr 1-2

teasp.

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o Sermorelin. GHRH) 1mcg/kg fasting in morning IV. o Sertindole. Adult 4mg daily, incr to 12-24mg daily oral. o Sertraline. 0.5mg/kg (adult 25mg) daily oral, incr if reqd to 1-2mg/kg (adult 50-100mg) daily; may give 3-4mg/kg (adult 150-200mg) daily for up to 8wk. o Sevelamer. 20-40mg/kg/dose (adult 800-1600mg) 8H oral, titraed to serum phosporus. o Sibutramine. Adult (NOT/kg): usually 10mg (range 5-15mg) daily oral. o Sildenafil. Adult sexual dysfunction: 25-100mg (NOT/kg): oral 1hr before sexual activity (max once/day) Pul hypertension: 0.3mg/kg/dose 3-6H incr until effective or systemis hypotension

occurs (usual max 2-3mg/kg/dose). o Silver nitrate, stick. Apply daily to affected area only. o Silver sulfadiazine 1% + chlorhexidine 0.2%. cream: apply in 3-5mm layer. o Simethicone. See aluminium hydroxide compound. o Simvastatin. Initially 0.2mg/kg (adult 10mg) daily, may incr every 4wk to max 1mg/kg (adult 40mg) daily oral. o Sirolimus. 3mg/m2 (adult 6mg) stat, then 1mg/m2 (adult 2mg) daily oral. o Sodium. Deficit: to increase serum Na by 0.5mmol/L/hr (maximum safe rate), infusion rate (ml/hr) = 2 x Wt(kg) /(% saline infused): number of hours of infusion = (140- serum Na) /8. 4ml/kg of

X% saline raises serum Na by Xmmol/L. Need 2-6mmol/kg/day. NaCI MW = 58.45, 1g NaCl = 17.1mmol Na, NaCl 20% = 3.4mmol/ml. o Sodium alginate. See alginic acid. o Sodium aurothiomalate. 0.25mg/kg wkly Im, incr to 1mg/kg (amx 50mg) weekly for 10ww, then every 2-6wk. IM, then every 1-4wk. o Sodium benzoate. Neonate: 250mg/kg over 2hr stat, then 10-20mg/kg/hr IV. o Sodium bicarbonate. See bicarbonate. o Sodium calcium edetate (EDTA). 25-40mg/kg/dose 12H IM or IV over 1hr for 5 days; repeat after 3 days if reqd. With dimercaprol: 12.5mg/kg 4H for 3-7 days. o Sodium cellulose phospate (Calcisorb). Adult: 5g/dose (NOT/kg) 8H oral. o Sodium chloride. See sodium. o Sodium citrotartrate. 40-80mg/kg/dose (adult 2-4g) in 50ml water 8-12H oral. o Sodium clodronate. 10-30mg/kg 9adult 0.6-1.8g) IV over 2hr every 2mo; or 6mg/kg (adult 300mg) IV over 2hr daily for 7 days, then 15-30/mg/kg/dose (adult 0.8-1.6g) 12H oral. o Sodium cromoglycate. Inhalation (Intal): 1 cap (20mg) 6-8h, 2ml soltn (20mg) 6-8H, aerosol 1-10mg 6-8H. Eye drops (2%): 1-2 drops per eye 4-6H , Oral:5-10mg/kg/dose (max 200mg) 6H oral.

Nasal (rynacrom): insufflator 5mg in each nostril 6H, spray 1 pugg in each nostri 6H. o Sodium ferric gluconate. Fe 12.5mg/ml. 0.05ml/kg (adult 2ml) test dose IV over 1hr, then 0.25mg/kg (adult 10ml) IV over 1hr with each dialysis (usually for 8 doses). o Sodium floride. NOT/kg: <2yr 0.55mg oral daily, 2-4yr 1.1mg, >4yr 2.2mg. Osteoporosis, Paget's bone secondaries in adult (NOT/kg): 20-40mg/dose 8-12H. o Sodium fusidate. Tablets: 10-15mg/kg (adult 250-500mg) 8H oral. IV over 2-8hr: 10mg/kg (adult 500mg) 8H; severe inftn 15mg/kg (adult 750mg). Peak level 30-200umol/L(x0.52 = mcg/ml). For

suspension, see fusidic acid. o Sodium hyaluronate. Adult (NOT/kg):Cystitis 800mcg/ml: 50ml into bladder wkly x4, then 4wkly. Ophthalmic: 10-15mg/ml (1-1.5%) 0.2-0.6ml into anterior chamber;0.18% drops 1-2/eye as

reqd. Osteoarthritis 10-15mg/ml:2-2.5ml intra-articular wkly x3-5. o Sodium nitrite. 3%: 0.2ml/kg (max 10ml) IV over 5min. o Sodium nitroprusside. IV infsn 0.5-10mcg/kg/min: child see p.47; for 65kg adult 50mg in 50ml at 2ml/hr is 0.5mcg/kg/min. if used for >24hr, max rate 4mcg/kg/min. Max total 70mg/kg with

normal renal function (or sodium thiocyanate ,1725 umol/L, x0.058=mg/L) Pul vasodil: 2mcg/kg/min nitrcpr = 5mcg/kg/min nitroglyc = 0.1mcg/kg/min PGE1 approx. o Sodium phenylbutyrate. 10-13g/m2/day divided into equal amounts with each feed or meal, oral. o Sodium phospate. See phospate, sodium. o Sodium picosulphate. 0.1-0.3mg/kg (adult 5-15ml) at night oral. o Sodium polystyrene sulphonate (Resonium). 0.3-1g/kg/dose (adult 15-30g) 6H NG (give lactulose) or PR.

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o Sodium stibogluconate. Soltn 100mg/ml of pentavalent antimony. 20mg/kg (usual max 850mg) daily IV over 5-10min for 20 days (visceral) or at least 4wk (mucocutaneous); 10-15mg/kg/dose 12H if toxicity or poor response. Early cutaneous; infiltrate lesions with 1-3ml, repeat x1-2 if reqd after 1-2 days. Severe cutaneous;20mg/kg daily IV over 5-10min until 3 days after cure (usually), for 4wk (L. braziliensis), or 3mo after cure (L.amazonensis).

o Sodium tetradocyl sulphate. NOT/kg: 0.25-1ml per vein as 1% (max 10 smalls veins) or 3% (max 4 large veins). o Sodium thiosulphate. 1ml/kg (adult 50ml) 25% soltn IV over 10min. o Sodium valproate. 5mg/kg/dose (adult 200mg) 8-12H oral, incr if reqd to max 2-0mg/kg/dose (adult 1g) 8-12H. Level 2hr after dose 300-700umol/l (x0.14=mg/l). o Somatostatin. See octreotide. o Somatrem. 4u/m2 3days a wk IM. o Somatropin. 1mg = 3iu. Usually 2-3iu/m2 on 5-7 days a wk SC, or 4-6iu/m2 on 3 days a wk IM. o Sorbitol 70%. 0.2-0.5ml/kg/dose (adult 20-30ml) 8-24H oral. With activated charcoal: 1g/kg (1.4ml/kg) NG,x1-2. o Sorbolone cream ; pur, with 10% glycerin, or with 5% or 10% olive oil or peanut oil. Skin moisturiser. apply pm. o Sotalol. IV: 0.5-2mg/kg/dose (adult 25-120mg) over 10min, 6H oral: 1-4mg/kg/dose (adult 50-160mg) 8-12H. o Sparfloxacin. 10mg/kg (adult 400mg) stat, then 5mg/kg (adult 200mg) daily oral. o Spectinomycin. 40-80mg/kg (adult 2-4g) IM once. o Spironolactone. Oral (NOT/kg); 0-10kg 6.25mg/dose 12H, 11-20kg 12.5mg/dose 12H, 21-40kg 25mg/dose 12H, over 40kg 25mg/dose 8H. Female hirsutism 50mg/dose 8H. IV. See potassium

canrenoate. o Stanolone. 2.5% gel, Male: apply 5-10g daily to a large area of skin and allow 5min to dry. Female (lichen sclerosus): apply 2.5g to vulva on alternate days. o Stanozolol. 0.05-0.2mg/kg oral (adult 2.5-10mg0 daily at first, then every 2-3 days. o Stavudine. (d4T). 20mg/m2/dose 12H oral. o Sterculia. NOT/kg:3.5-7g/dose 12-24H oral. o Stibogluconate. See sodium stibogluconate. o Stilboestrol. Ca breast (NOT/kg):10-20mg daily oral, Caprostate: 1-3mg daily oral or IV o Streptokinase (SK). Shotr term (myoc infarct): 30,000u/kg (max 1,500,000u) IvV over 60min, repeat if occlusion recurs < 5days . Long term (DVT, put emb, art thrombosis): 2,000u/kg (max

100,000u) IV over 10min, then 1000u/kg/hr (max 100,000u/hr); stop heparin and aspirin, if PTT < x2 normal at 4hr give extra 10,000u/kg (max 500,000u) IV over 30min, stop SK if PTT >x5 normal then give 1000u/kg/hr. Local infsn: 50 u/kg/hr (continue heparin 10-15u/kg/hr). Blocked IV cannula: 5000u/kg in 2ml in cannula for 2hr then remove, may repeat x2.

o Streptomycin. 20-30mg/kg (max 1g) IM daily. o Streptozocin. 1-1.5g/m2 wkly IV. o Succimer. 350mg/m2 8H for 5 days, then 12H for 14 days oral. o Succynil choline. See suxamethonium. o Sucralfate. 1g tab (NOT/kg): 0-2yr quarter tab 6H, 3-12yr half tab 6H, >12yr 1 tab 6H oral. o Sufentanil. 2-50mcg/kg slow IV; may then infuse so that total dose is 1mcg/kg/hr of expected surgical time. o Sulbactam. See ampicillin + sulbactam. o Sulfacetamide. See sulphacetamide. o Sulfadiazine. 50mg/kg/dose (max 2g) 6H slow IV. o Sulfadoxine. See pyrimethamine and sulfadoxine. o Sulfamethizole. See sulphamethizole. o Sulfamethoxazole. See cotrimoxazole. o Sulfametopyrazine. 40mg/kg (adult 2g) wkly oral. o Sulfasalazine. See sulphasalazine. o Sulfinpyrazone. See sulphinpyrazone.

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o Sulfisoxazole. See sulphafurazole. o Sulindac. 4mg/kg/dose (adult 200mg) 12H oral. o Sulphacetamide 10% + prednisolone 0.2% + phenylephrine 0.12%. 1 drop/eye 6-12H. o Sulphafurazole. 75mg/kg (adult 4g) stat, then 35mg/kg/dose (adult 1.5g) 4-6H oral. o Sulphamethizole. 10mg/kg/dose (adult 0.5-1g) 6H oral. o Sulphamethoxazole. See cotrimoxazole. o Sulphasalazine. Active colitis: 20mg/kg/dose 6-12H (max 4g/day) oral;remission 7.5mg/kg/dose (max0.5g) 6-8H, soppos (NOT/kg): adult 0.5-1g 12H ( max 2g/day). o Sulphinpyrazone. 2-3mg/kg/dose (max 200mg) 6-12H oral. o Sulpiride. 4mg/kg/dose (adult 200mg) 12H, slow incr if reqdd to 4-24mg/kg/dose (adult 0.2-1.2g) 12H oral. o Sulthiame. 1mg/kg/dose (adult 50mg) 8-12H oral, may incr to 5mg/kg/dose (adult 200mg) 8H. o Sumatriptan. Oral: 1-2mg/kg (adult 50-100mg) stat, may repeat twice. SC: 0.12mg/kg (max 6mg) stat, may repeat once after 1hr. Nasal: 10-20mg, may repeat x1 after 2hr. o Surfactant. See beractant (Survanta), callactant(Infasurf), colfosceril palmitate (Exosurf), poractant alfa (Curosurf), pumactant (ALEC). o Suxamethonium. IV: neonate 3mg/kg/dose, chlid 2mg/kg/dose, adult 1mg/kg/dose. IM:double IV dose.

T o Tacrine. Adult (NOT/kg): 10mg/dose 6H oral for 6wk, then incr if reqd by 10mg every 6wk to max 40mg/dose 6H. o Tacrolimus. IV infsn: 2mg/m2/day. Oral: 3mg/m2/dose 12H. Trough level: whole blood 10-15ng/ml (sent to Austin dailt at 1000 from RCH). o Tacrolimus ointment. 2-16yr: apply 0.03% sparingly 12H for max 3wk, then daily. >16yr: apply 0.1% sparingly 12H for max 3wk, then 0.03% 12H. o Tamoxifen. Adult (NOT/kg): 20mg daily, incr to 40mg daily if no response after 1mo. o Tamsulosin. Adult 400mcg daily after breakfast oral. o Tar. See coal tar. o Tazarotene. 0.05%, 0.1% gel, cream: apply a thin layer to affected area daily(or on alternate days) in the evening. o Tazobactam 125mg + piperacilllin 1g. See piperacillin. o Tegaserod. Adult (NOT/kg): 6mg 12H for 4-12wk oral. o Teiclopanin. 250mg/m2 IV over 30min stat, then 125mg/m2 IV or IM daily. Severe inftn: 250mg/m2 12H x3 doses, then 250mg/m2 IV or IM daily. o Telmisartan. 1mg/kg (adult 40mg) daily, incr if reqd to 2mg/kg (adult 80mg) daily oral. o Temazepam. 0.3mg/kg (adult 20-40mg) oral. o Temocillin. 25-50mg/kg/dose (adult 1-2g) 12H IV or IM. o Temozolomide. 200mg/m2 daily oral for 5 days per 28 day cycle (150mg/m2 for first cycle if previous chemotrapy). o Tenecteplase. 1mg = 200u. Myocar infarct (adult): 100u/kg (max 10,000u) IV over 10sec once ; also give aspirin 150-325mg/day, and heparin to maintain APTT 50-75sec o Teniposide. 100-150mg/m2 IV over 1hr wkly. o Tenofovir. Adult (NOT/kg): 300mg daily oral. o Tenoxicam. 0.2-0.4mg/kg (adult 10-20mg) daily oral. o Terazosin. 0.02mg/kg test, then 0.04-0.4mg/kg (adult 2-200mg) daily oral. o Terbinafine. 62.5mg (<20kg), 125mg (20-40kg), 250mg (adult) daily oral. 1% cream, gel: apply 12-24H to dry skin. o Terbutaline. Oral:0.05-0.1mg/kg/dose (adult 2.5-5mg) 6H. SC: 5-10mcg/kg/dose (adult 0.25-0.5mg). IV: child 3-6mch/kg/min for 1hr, then 0.4-1mcg/kg/min ; adult 0.25mg stat over 10min,

then 1-10mcg/kg/hr. Inhaltn ; mild resp soltn (1%, 10mg/ml) 0.25ml/dose diluted to 4ml 3-6H ; moderate 0.5ml of 1% diluted to 4ml, or respule 5mg/2ml 1-2H ; severe (in ICU) undiluted continuous. Aerosol 250mcg/puff : 1-2 puffs 4-6H.

o Terfenadine. 30mg (6-12 yr), 60mg (adult) 12H oral. o Terliprssin. 0.04mg/kg/dose (adult 2mg) IV, then 0.02-0.04mg/kg/dose (adult 1-2mg) 4-6H fo max 72hr.

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o Testolactone. 5-10mg/kg/dose (max 250mg) 6H oral. o Testosterone. Esters (NOT/kg): 100-500mg IM every 2-4wk. Implant: 8mg/kg (to nearest 100mg) every 16-24wk, Undecanoate (NOT/kg): 40mg daily oral, incr to 80-120mg daily. Testosterone

level: <16yr 5-10nmol/L, >16yr 10-30nmol/L. o Tetanus toxoid (Tet-Tox). 0.5ml IM stat, 6wk later, and 6mo later. Boost every 10yr, or if contaminated wound. See also diptheria (+pertussis) + tetanus vaccines. o Tetrabenazine. 0.5-2mg/kg/dose (adult 25-100mg) 12H oral. o Tetracaine. See amethocaine. o Tetracosactrin zinc injection (Synacthen Depot). 600mcg/m2 (max 1mg) IM every 1-7 days. o Tetracylline. >8yr (NOT/kg): 250-500mg/dose 6H oral. Acne (NOT/kg): 500mg/dose 12H, reducing to 250mg 12H. Eye: apply 2-8H. See also rolitetracylline. o Tetrahydrobiopterin. Defective synthesis: 20mg/kg daily oral. Defective regeneration:5mg/kg/dose 6H ,oral. Loading test: 20mg/kg oral, 2mg/kg IV. o Tetrahydrozoline. 0.05%: 1-2 drops/eye 8-12H. o Tetrahydrozoline 0.05% + macrogol 400 (polyethyleneglycol) 1% 1-2 drop/eye 8-12H. o Thalidomide. 4mg/kg/dose (adult 200mg) 12H oral, reducing over 2-4wk to 0.5-1mg/kg/dose 9adult 25-50mg) 12H. o THAM. See trometamol. o Theophylline. 80mg theophylline = 100mg aminophilline. Loading dose: 8mg/kg 9max 500mg) oral. Maintenance: 1st wk life 2mg/kg/dose 12H: 2nd wk 3mg/kg/dose 12H;3wk-12mo (0.1 x age

in wk) + 3mg/kg/dose 8H;, 1-9yr 4mg/kg/dose 4-6H, or 10mg/kg/dose sloe rel 12H; 10-16yr or adult smoker 3mg/kg/dose 4-6H, or 7mg/kg/dose 12H slow rel; adult non-smoker 3mg/kg/dose 6-8H;elderly 2mg/kg/dose 6-8H. serum level;neonate 60-80umol/L, asthma 60-110 (x0.18 = mcg/ml), done as reqd at RCH.

o Thiabendazole. 25mg/kg/dose (max1.5g) 12H oral 3 days. o Thiamine. Beriberi: 1-2mg/kg IV, IM or oral daily. Metabolicdis (NOT/kg): 100mg/dose 8H IV, IM, SC,oral. o Thiethylperazine maleate. >10kg: 0.2mg/kg/dose (adult 10mg) 8-24H oral, IM or PR. o Thioguanine. 100mg/m2 daily oral;or 100mg/m2/dose 12H for 5-7 days. o Thiopental. See thiopentone. o Thiopentone. 2-5mg/kg slowly stat(beware hypotension), then 1-5mg/kg/hr IV. Level 150-200umol/L (x0.24=mcg/ml). o Thioridazine. 0.5-3mg/kg/dose (adult 25-150mg) 6-8H oral or IM. o Thiosulphate. See sodium thiosulphate. o Thiotepa. 10-14mg/m2 IV every 1-4wk. o Thiotepa. 1 in 2000: 2 drops/eye 4-6H for 6wk. o Thiothexene. >12yr (NOT/kg): initially 2mg/dose 8H oral, slow incr to 2-20mg per dose o Threonine. 15-30mg/kg/dose (adult 0.75-1.5g) 8H oral. o Thrombin glue. 10,000u thrombin in 9ml mixed with 1ml 10% calcium chloride in syringe 1, 10ml cryoprecipitate in syringe 2: apply to bleeding sites together. Do not inject. o Thrombin, topical. 100-2000u/ml onto bleeding surface. o Thymidine. 75g/m2 every 4-6wk IV over 24hr. o Thymoxamine. Adult (NOT/kg): 40-80mg/dose 6H oral. o Thyrotropin alfa. Adult(NOT/kg);0.9mg IM 24H x2 doses, or 72H x3 doses. o Thyroxine. 50mcg tab. 100mcg/m2 rounded to nearest quarter tab (adult 100-200mcg) daily oral. o Tiagabine. Usually 0.1mg/kg/dose (adult 5mg) 12H, incr wkly to 0.1-0.5mg/kg/dose (adult 5-15mg) 8H oral. o Tiaprofenic acid. 2-4mg/kg/dose (adult 100-200mg) 8H oral. o Tibolone. Adult(NOT/kg):2.5mg daily oral. o Ticarcillin. 50mg/kg/dose (adult 3g) IV 6-8H (1st wk life), 4-6H or constant infsn (2+wk). Cystic fibrosis: 100mg/kg (max 6g) 8H IV. o Tick-borne encephalitis vaccine. Killed. 0.5ml IM stat, after 4-12wk, and after 9-12mo. Boost every 3-6yr. o Ticlopidine. 5mg/kg/dose (adult 250mg) 12H oral.

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o Tilactase. 200u/drop: 5-15 drop/L added to milk 24hr be\fore use. 3300u/tabs with meals oral. o Tiludronate disodium. Adult 400mg daily for 12 wk oral. o Tiludronic acid. See tiludronic acid. o Timolol. 0.1mg/kg/dose (adult 5mg) 8-12H, incr to max 0.3mg/kg/dose (adult 15mg) 8H, Eye drops (0.25%,0.5%): 1drop/eye 12-24H; see also latonoprost. o Tinidazole. Giardia:50mg/kg (adult 2g) stat, repeat after 48hr. Amoebic dys: 50mg/kg (adult 2g) daily for 3 days. o Tinzaparin. 1mg = 75 anti-Xa IU. Prophylaxis: 50u/kg SC 2hr before surgery, then daily for 7-10 days. Treatment: 175u/kg SC daily for at least 6 days. o Tioconazole. 280mg/ml:apply to nails 12H for 6-12mo. o Tiopronin. 3-10mg/kg/dose (adult 150-500mg) 6-8H oral. o Tiotropium. Adult(NOT/kg): 18mcg cap daily by inhaler. o Tirilazad. 1.5mg/kg/dose 6H IV over 30min. o Tirofiban. 0.4mcg/kg/min for 30min, then 0.1mcg/kg/min for 2-5days;also give heparin to APTT x2 normal. o Tissue plasminogen activator. See altiplase. o Tizanidine. 0.01mg/kg/dose (adult 0.5mg) 8H, incr gradually to 0.1-0.25mg/kg/dose (adult 6-12mg) 8H oral. o Tobramycin. Single daily dose IV or IM. Neonate: 5mg/kg stat, then 2.5mg/kg (<30wk) 3.5mg/kg (30-35wk) 5mg/kg (term <1wk) daily. 1wk-10yr: 8mg/kg 1, then 6mg/kg daily. >10yr;7mg/kg

day 1, then 5mg/kg daily (max 240-360mg) daily. Inhaltn;80mg diluted to 4ml 12H; or TOBI 300mg 12H alternate minths. Eye: 1drop or 1cm cream 4H. Trough level <1.0mg/L, done daily 1000,1600 RCH.

o Tocanide. 5-10mg/kg/dose (max 400-800mg) 8-12H IV over 30min or oral. o Tocopherol. See alpha-tocopheryl acetate, and vitamin E. o Tolazamide. 2-5mg/kg/dose (adult 100-250mg) 6-24H oral. o Tolazoline. Newborn:1-2mg/kg slowly stat (beware hypotension), rhen 2-6mcg/kg/min (0.12-0.36mg/kg/hr) IV. Note:1-2mg/kg/hr to much (Pediatrics 1986;77:307). o Tolbutamide. Adult (NOT/kg): initially 1g 12H oral, often reducing to 0.5-1g daily. o Tolcapone. Adult (NOT/kg):100mg 8H oral; if no response, try maximum dose of 200mg 8H. Monitor ALT and AST. o Tolfenamic acid. 4mg/kg (adult 200mg) oral, may repeat once after 2hr. o Tolmetin. 5-10mg/kg/dose (adult 400-600mg) 8H oral. o Tolnaftate. 1% cream, ointment, powdr, soltn: apply 8-12H. o Tolterodine. 0.05mg/kg/dose (adult 2mg) 12H oral. Slow rel: adult 2-4mg daily oral. o Topiramate. 1mg/kg/dose (adult 50mg) 12-24H oral, incr gradually to 4-10mg/kg/dose (adult 100-500mg) 12H. o Topotecan. 1.5mg/m2 daily x5 IV over 30min, repeat every 3wk for at least 4 courses. o Torsemide. See torasemide. o Torasemide. 0.1-1mg/kg(adult 5-50mg) daily oral or IV. Rarely up to 4mg/kg (adult 200mg) daily in renal failure. o Toremifene. Adult (NOT/kg): 60mg daily oral. o Tramadol. Oral: 1-2mg/kg/dose (adult 50-100mg) 4-6H (max 400mg/day). IV over 3min, IM: 1-2mg/kg/dose (adult 50-100mg) 4-6H (max 600mg/day), or 2-8mcg/kg/min IV. o Tramazoline. Nasal:82mcg/dose each nostril x3-6/day. o Tramazoline 120mcg + dexamethazone 20mcg per dose. Aerosol: 1 puff in each nostril 4-8H. o Trandolapril. 0.01-0.1mg/kg (adult 0.5-4mg) daily oral. o Tranexanic acid. Oral: 15-25mg/kg/dose (adult 1-1.5g) 8H. IV: 10-15mg/kg/dose (adult 0.5-1g) 8H. o Tranylcipromine. 0.2mg/kg/dose (adult 10mg) 8-12H oral. o Trastuzumab. 4mg/kg IV over 90min loading dose, then 2mg/kg IV over 30min wkly. o Trovoprost. 0.004% 1drop/eye in evening. o Trazodone. 1-4mg/kg/dose (adult 50-200mg) 8H oral.

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o Trepprotinil. 1.25mg/kg/min SC infsn, incr each wk by 1.25-2.5mg/kg/min to max 20-40mg/kg/min. o Tretinoin. 22.5mg/m2 12H oral, cream or lotion 0.05%, gel 0.01%: apply daily for 3-4 months, then x1-3/wk. o Triacetyloleandomycin. 6-12mg/kg/dose (adult 250-500mg) 6H oral. o Triamcinolone. Joint, tendon (NOT/kg): 2.5-15mg stat. IM:0.05-0.2mg/kg every 1-7 days. Cream or ointment 0.02%, 0.05%: apply sparingly 6-8H. Triamcinolone has no mineralcorticoid action,

1mg=5mg hydrocortisone in glucocorticoid action. o Triamcinolone 0.1% + neomycin 0.25% + gramicidin 0.025% + nystatin 100,000u/g. Kenacomb ointment: apply 8-12H. Kenacomb otic oint, drops: apply 8-12H (2-3 drops). o Triamterene. 2mg/kg/dose (adult 100mg) 8-24H oral. o Triazolam. 0.005-0.01mg/kg (adult 0.125-0.5mg) at night oral. 30min preop: 0.01-0.03mg/kg (adult 0.5mg) oral. o Tribavirin. See ribavirin. o Triclosan. 0.5%-5% lotion: 2ml wet skin for 30sec, rinse and repeat. Bath oil: 20ml in 20cm bath, soak 15min. o Trientine. 10mg/kg/dose (adult 500mg) 6-12H oral. o Triethylenethioposphoramide. See thiotepa. o Trifluoperazine. 0.02-0.4mg/kg/dose (adult 1-10mg, occasionally 20mg) 12H oral. Capsule: adult 15mg daily. o Trifluridine. 1% soltn: 1drop/eye 2H (max 9drops/day) until epithealialised, then 4H (max 5drops/day) for 7 days. o Trihexypenydyl. See benzhexol. o Trilodothyronine (T3). See liothyronine. o Trilostane. 0.5-4mg/kg/dose (adult 30-240mg) 6H oral. o Trimeprazine. Antihist: 0.1-0.5mg/kg/dose (adult 2.5-25mg) 6H oral, Sedatin: 0.5-1mg/kg IM, 2-4mg/kg oral. o Trimethobenzamide. 5mg/kg/dose (adult 250mg) 6-8H oral, IM or PR. o Trimethoprim. 3-4mg/kg/dose (usual max 150mg) 12H, or 6-8mg/kg (usual max 300mg) daily oral or IV. Urine prophylaxis: 1-2mg/kg (adult 150mg) at night oral. o Trimethoprim-sulphamethoxazole. See cotrimoxazole. o Trimetrexate. 45mg/m2 IV over 90min daily for 21 days, with folinic acid 20mg/m2/dose IV over 10min 6H for 24 days (ie for 3 dys longer than the trimetrexate). o Trimipramine. 1-2mg/kg/dose (adult 50-100mg) 8-24H oral. o Trioxsalen. See trioxysalen. o Trioxysalen. Adult: 5-10mg daily 2hr before UV exposure. o Tripelennamine. 1.25mg/kg/dose (adult 75mg) 6H oral. o Tripotassium dicitratobismuthate. See bismuth subcitrate. o Triprolidine 2.5mg + pseudoephedrine 60mg (Actifed). 10ml elixir = 1 tab. NOT/kg: 2.5ml (<2yr), 2.5-5ml (2-5yr), 0.5 tab (6-12yr), 1tab (>12yr) 6-8H oral. o Triptorelin. Adult (NOT/kg): Depot:3.75-4.2mg IM every 28 days. Long acting: 11.25mg IM every 12wk. o Trisodium edetate. 40-70mg/kg (max 3g) IV over 6hr daily for 5 days ; max 3 courses each 2 days apart. o Troleandomycin. See triacetyloleandomycin. o Trometamol (THAM). Ml of 0.3molar (18g/500ml) soltn=Wt x BE (give half this) IV over 30-60min. o Tropicamide. 0.5%, 1%: 1-2 drop/eye, repeat after 5min. o Tropisetron. 0.1mg/kg (adult 5mg) slow IV just before chemotherapy, then oral 12-24H. o Trospium chloride. 0.4mg/kg/dose (adult 20mg) 12H oral. o Trovafloxacin. 4mg/kg (adult 200mg) daily oral, Severe inftn: 6mg/kg (adult 300mg) daily oral. o Tryptopan, L isomer. Adult 1-2g/dose 8H oral. o Tyloxapol. See colfosceril palmitate. o Tulobuterol. 0.04mg/kg/dose (adult 2mg) 8-12H oral. o Typhoid vaccine, oral (Typh-Vax). Live. 1 cap oral days 1, 3,5 and (for better immunity) 7. Boost yearly.

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o Typhoid vaccine, parenteral, polysaccharide (Typherix, Typhim IV). Inactivated. >5yr: 0.5ml once. Boost 3 yrly.

U o Ubidecarenone. 1-4mg/kg (adult 50-200mg) daily oral. o Urea. 10% cream: apply 8-12H. o Urofollitrophin. See follicte stimulating hormone. o Urokinase. 4000u/kg IV over 10min, then 4000u/kg/hr for 12hr (start heparin 3-4hr later). Blocked cannula: instill 5000-25000u(NOT/kg) in 2-3ml saline for 2-4hr. Empyema: 2ml/kg of

1500u/ml in saline, position head up/down and right side up/down 30min each, then drain. Pericard aff: 10,000u/ml, 1ml/kg (max 20ml), clamp 1hr, drain. o Ursodeoxycholid acid. 5-10mg/kg/dose (adult 200-400mg) 12H oral. o Ursodiol. See ursodeoxycholic acid.

V o Valaciclovir. 20mg/kg/dose (adult 1g) 8H oral. Genital herpes (NOT/kg): treatment 500mg/dose 12H, prevention 500mg dailyt (<10 episodes/yr) 1g daily (>9episodes/yr). o Valcyte. Adult (NOT/kg): 900mg/dose 12H oral for 3wk, then 900mg daily. o Valdecoxib. Adult (NOT/kg): 10mg daily (Arthritis), 220mg 12H (dysmenorrhoea) oral. o Valganciclovir. Adult (NOT/kg): 900mg 12H oral with food for 21 days, then 900mg daily. o Valproic acid, valproate. See sodium valproate. o Valburicin. Adult (NOT/kg): 800mg wjkly x6 intravesical. o Valsartan. 0.8-3mg/kg (adult 40-160mg) daily oral. o Vancomycin. 10mg/kg/dose (adult 500mg) 6H IV over 1hr, or 1g/dose 12H in adult IV over 1hr. Newborn (any gestation): 10mg/kg/dose 8H IV over 1hr. Oral: 10mg/kg/dose to nearest 125mg

(adult 500mg) 6H. Intraventric (NOT/kg): 10mg/dose 48H. Trough 5-15mg/L (peak 25-40mg/L), done Mo-Fri 1000, 1600, 2200 at RCH. o Varicella vaccine (Varillix, varivax). Live 9mo-12yr: 0.5ml SC once. >12yr: 0.5ml SC stat, and 4-8wk later. o Vasopressin, aqueous. IM, SC: 2.5-10u 6-12H. IV: pu 2-5u in 1L fluid, and replace urine output + 10%. Brain death: 0.0003u/kg/min (1u/kg in 50ml at 1ml/hr) + adrenaline 0.1-0.2mcg/kg/min.

GI he: 6u/kg in 50ml at 1-5ml/hr IV, 1ml/hr local IA. See desmopressin and hypressin. o Vasopressin, oilty. 2.5-5u (NOT/kg) IM every 2-4 days. o Vecuronium. ICU: 0.1mg/kg pm. Theatre: 0.1mg/kg stat, then 1-10mcg/kg/min IV. o Venlafaxine. Adult (NOT/kg): 37.5mg/dose 12H oral, inr if reqd to max 150mg 12H. Slow rel: 75mg daily oral, incr if reqd to max 225mg daily. o Verapamil. IV: 0.1-0.2mg/kg (adult 5-10mg) over 10min, then 5mcg/kg/min. Oral: 1-3mg/kg/dose (adult 80-120mg) 8-12H. o Versenate. See sodium calciumedetate. o Verteporfin. 6mg/m2 over 10min IV: 15min after start of infsn give diode laser of 689nm at 600mW/cm2 for 83sec. o Vidarabine. Eye ointment:x5/day until epithealialished, then 12H 7 days. IV infsn: 10mg/kg/day 5-10days (varicella zoster), days, 15mg/kg/day 10 days (herpes encephalitis). o Vigabatrin. 40mg/kg (adult 1g) daily oral, incr if reqd to 80-150mg/kg (max 4g) daily (given in 1-2 doses). o Viloxazine. 2-5mg/kg (adult 100-250mg) morning, and 2-3mg/kg (adult 100-150mg) noon oral. Elderly: 100mg daily. o Vinblastine. 6.5mg/m2 IV over 1min every 1-4wk. o Vincristine. 1.5mg/m2 wkly IV over 1min. o Vindesine. 3-4mg/m2 IV every 7-10day if WCC>2500/mm3. o Vinorelbine. 30mg/m2 IV over 10min weekly. o Vitamin A. High Risk (NOT/kg): 100,000iu (<8kg), 200,000iu (>8kg) oral or IM every 4-6mo. Severe measles: 400,000iu (NOT/kg): once, Cystic fib: 1500u daily (<3yr) 5000u daily (3-10yr) 10000u

daily (>10yr) oral. >10,000iu daily for >25000u per wk may be teratogenic.

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o Vitamin A,B,C,D compound (Pentavite, infant). <3yr (NOT/kg): 0.15ml daily, incr by 0.15ml/day to 0.45ml/day. o Vitamin A,B,C,D compound (Pentavite, child). <3yr (NOT/kg):2.5ml daily. >3yr(NOT/kg):5ml daily. o Vitamin B1 group. Amp: IV over 30min. Tab: 1-2/day. o Vitamin B1. See thiamine. o Vitamin B2. Metabolic dis: 50-150mg 12-24H oral. o Vitamin B6. See pyridoxine. o Vitamin B12. See hydroxocobalamin. o Vitamin C. See ascorbic acid. o Vitamin D2. (ergocarciferol). 40u=1mcg=1mcg cholecalciferol(D3). Cystic fib, cholestasis: 10-20mcg daily oral. Chirrhosis: adult 40-120mcg daily oral. Deficiency: 50-100mcg daily for 2wk oral,

then 10-625mcg daily (more if severe malabs); or 100,000-200,000u every 6-8wk. Measure level after 6-8wk. See also doxelcalciferol. o Vitamin D3 (cholecalciferol). 1mg = 1mcg D2. Osteodys trophy: 0.2mcg/kg (hepatic) 15-40mcg/kg (renal) daily oral. o Vitamin E. 1u = 1mg. Preterm babies, Coperol E (NOT/kg): 40u (2drops) daily oral. CF, malabs: 50-100u (<3yr) 200-400 (>3yr) daily oral. Cholestasis: 50u/kg daily oral, incr if reqd in 50u/kg

increments. A-beta-lipoproteinaemia: 35-70u/kg/dose 8H oral. HUS: 0.25g/m2/dose 6H oral. See also-alpha-tocopheryl. o Vitamin K1. See phytomenadione. o vitamin K3. See menapthone sodium bisulphite. o Vitamins, parenteral. MVI-12 (for adult): 5ml in 1 litre IV fluid. MVI paediatric, added to IV fluid: 655 of a vial (<3kg), 1 vial (3kg to 11yr). o Vitaprem (RCH: pentavite, folate, B12, C). 1ml daily oral. o Voriconazole. Oral, IV over 2hr: 6mg/kg (child >2yr) 200mg (adult <40kg) 400mg (adult >40kg) repeated after 12hr, then 4mg/kg/dose (child >2yr) 100mg (adult<40kg) 200mg (adult >40kg)

12H. incr maintenance by 50% if reqd.

W o Warfarin. Usually 0.2mg/kg (adult 5mg) stat, 0.2mg/kg (adult 5mg) next day providing INR <1.3, then 0.05-0.2mg/kg (adult 2-5mg) daily oral. INR usually 2-2.5 for prophylaxis, 2-3 for

treatment. Beware drug interactions. o Whole blood. 6ml/kg raises Hb 1g%. 1bag = 400ml approx.

X o Xamoterol. 4mg/kg/dose (adult 200mg) 12-24h oral. o Xipamide. 0.5-1.5mg/kg (adult 20-80mg) daily oral. o Xylomethazoline. <6yr: 0.05% 1 drop or spray 8-12H. 6-12yr: 0.05% 2-3 drops or sprays 8-12H. >12yr: 0.1% 2-3 drops or sprays 6-12H.

Y o Yellow fever vaccine (Stamaril). Live. >12mo: 0.5ml SC once. Boost every 10yr. o Yohimbine. 0.05-0.1mg/kg/dose (adult 2.75-5.4mg) 8H oral.

Z o Zafirlukast. NOT/kg: 10mg/dose (child >7yr) 20-40mg/dose (adult) 12H oral. o Zalcitabine. Usually 0.01mfg/kg/dose (adult 0.75mg) 8H oral.

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o Zalepion. 0.2mg/kg (adult 10mg) at night oral. o Zanamivir. Adult (NOT/kg): 10mg 12H for 5 days inhaled. o Zidovudine (AZT). Preterm:1.5mg/kg/dose 12H to 2wk, then 2mg/kg/dose 8H. Term newborn: 2mg/kg/dose 6H oral, 1.5mg/kg/dose 6H IV. Child: usually 160mg/m2/dose 8H oral,

120mg/m2/dose 6H IV, or 20mg/m2/hr IV; range 90-180mg/m2/dose 6-8H. Adult (NOT/kg): usually 200mg/dose 8H oral, or 150mg/dose 8H IV. o Zileuton. Adult (NOT/kg): 600mg 6H oral. o Zinc chloride. 5.3mg/ml = 2.5mg/ml Zn = 38umol/ml Zn. 4umol/kg/day (<1yr), 1umol/kg/day (child), 40-60umol/day (adult). Serum zinc 11-22umol/l. o Zinc sulphate. (220mg cap = 50mg Zn = 765umol Zn). Deficiency, acroderm enteropath: initially 3mg/kg/dose (adult 220mg) 8-12H oral, adjusted to achieve serum zinc 11-22umol/L (0.7-

1.4mg/L). Diarrhoea child (NOT/kg); 10-20mg daily oral. o Ziprasidone. Adult (NOT/kg);20mg/dose 12H incr if reqd to max 80mg/dose 12H oral. o Zoledronic acid. Hypercalcaemia (adult, NOT/kg): 4mg IV over 15min, 8mg if relapse after minimum of 7 days. Usually repeated every 4wk. o Zolmitriptan. 0.05-0.1mg/kg (adult 2.5-5mg) oral, then 2H if reqd: max 0.3mg/kg (adult 15mg) in 24hr. o Zolpidem. 0.1-0.4mg/kg/dose (adult 5-20mg) nocte oral. o Zonisamide. 2mg/kg/dose (adult 100mg) daily oral, incr if reqd after 2wk to 12H, then 3mg/kg/dose (adult 150mg) 12h, then 4mg/kg/dose (adult 200mg) 12H ; rarely up to 6mg/kg/dose (adult

300mg) 12H level 10-20mg/l. o Zopiclone. 0.1-0.3mg/kg (adult 5-15mg) at bedtime oral. o Zotepine. 0.5mg/kg/dose (adult 25mg) 8H oral, adjusted every 4 days to 0.5-2mg/kg/dose 8H. o Zuclopenthixol. 0.4-3.0mg/kg (adult 20-150mg) daily oral.

Ditulis Ulang Oleh : Dr. H. Rohmat Pujo Santoso

Kasi Pelayanan Medik & Keperawatan Rumah Sakit Daerah Balung Kabupaten Jember