DNAk = HSP70
11
description
DNAk = HSP70. Anfinsen Cage. 1-2) SRP binds leader peptide (pausing translation), which will take it to the proper location 3) Once in place SRP falls off and the ribosome continues to translate protein 4) A peptidase cleaves the leader peptide and then BIP - PowerPoint PPT Presentation
Transcript of DNAk = HSP70
DNAk = HSP70
Anfinsen Cage
“Leader peptide”
1-2) SRP binds leader peptide (pausing translation), which will take it to the proper location
3) Once in place SRP falls off and the ribosome continues to translate protein
4) A peptidase cleaves the leader peptide and then BIP (an HSP70 like protein) binds to facilitate proper folding.
5) Dissociation of complex
Nobel Prize2004
Cancer treatmentTargeting the proteasome
Ubiquitin tagging
