DNA Mutations and Repair

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DNA Mutations and Repair Chapter 17

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DNA Mutations and Repair. Chapter 17. Detecting mutations with the AMES test. SUMMARY OF AMES TEST. AMES TEST. Saccharin Aflatoxin. 2-aminofluorene. Aflatoxin B1. DNA Repair: general characteristics. Double stranded DNA Redundancy of pathways. Types of DNA repair. Mismatch repair - PowerPoint PPT Presentation

Transcript of DNA Mutations and Repair

Page 1: DNA Mutations and Repair

DNA Mutations and Repair

Chapter 17

Page 2: DNA Mutations and Repair

Detecting mutations with the AMES test

Page 3: DNA Mutations and Repair
Page 4: DNA Mutations and Repair

SUMMARY OF AMES TEST

Page 5: DNA Mutations and Repair

AMES TEST

• Saccharin

• Aflatoxin

2-aminofluorene

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Aflatoxin B1

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DNA Repair: general characteristics

• Double stranded DNA• Redundancy of pathways

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Types of DNA repair

• Mismatch repair

• Direct Repair

• Base-Excision Repair

• Nucleotide Excision Repair

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Mismatch repair

• Mut H– Recognize GATC hemi-methylation

• Mut S• Mut L

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A closer look at mismatch repair

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Direct Repair

DIRECT REVERSAL REPAIR

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BASE EXCISION REPAIR

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BASE EXCISION REPAIR

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Nucleotide Excision Repair

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Diseases of DNA repair!

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Xeroderma pigmentosumAutosomal recessive

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Hereditary Non-Polyposis Colon Cancer

• HNPCC

• 15% of all colon cancers

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Li-Fraumeni

• P-53 mutation

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Page 20: DNA Mutations and Repair

DNA repair and mutations during quiescence in yeast

DNA repair and mutations during quiescence in yeast

DNA and Mutations - rbvbiotech2019.weebly.com€¦ · Types of Mutations Point mutations Frameshift mutations Chromosomal mutations. THE DOG BIT THE CAT DNA Types of Mutations. THE

DNA and Mutations - rbvbiotech2019.weebly.com€¦ · Types of Mutations Point mutations Frameshift mutations Chromosomal mutations. THE DOG BIT THE CAT DNA Types of Mutations. THE

DNA, PROTEIN SYNTHESIS, & Mutations

DNA, PROTEIN SYNTHESIS, & Mutations

DNA, genes, and mutations

DNA, genes, and mutations

MUTATIONS & DNA REPAIR MECHANISMS

MUTATIONS & DNA REPAIR MECHANISMS

DNA Mutations and Repair

DNA Mutations and Repair

Mutations of the DNA repair endonuclease ERCC4/XPF cause ... · Mutations of the DNA repair endonuclease ERCC4/XPF cause Fanconi anemia Massimo Bogliolo 1,2,10, Beatrice Schuster

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Mutations and DNA Repair

Mutations and DNA Repair

MUTATIONS Mutations Changes to DNA are called mutations change the DNA changes the mRNA may change protein may change trait DNA TACGCACATTTACGTACG.

MUTATIONS Mutations Changes to DNA are called mutations change the DNA changes the mRNA may change protein may change trait DNA TACGCACATTTACGTACG.

Chapter 7a - DNA mutation and repair: Mutation and adaptation Types of mutations DNA repair mechanisms.

Chapter 7a - DNA mutation and repair: Mutation and adaptation Types of mutations DNA repair mechanisms.

DNA Mutations and Repair Chapter 18 Part 1. Gene Mutations and Repair Nature of mutations Causes of mutations Study of mutations DNA repair.

DNA Mutations and Repair Chapter 18 Part 1. Gene Mutations and Repair Nature of mutations Causes of mutations Study of mutations DNA repair.

12.6 DNA Repair. DNA Repair Errors in DNA replication or damage to DNA create mutations Errors in DNA replication or damage to DNA create mutations -

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Mutations & DNA Repairlms.bums.ac.ir/.../attachment/7650/mutation_andrepair.pdf · 2014-02-24 · Mutations & DNA Repair I. ... Mutagenesis: Process of producing a mutation III. Testing

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Mutations & DNA Repair - WOU

Mutations & DNA Repair - WOU

DNA DAMAGE Damage_RSDFY20-863… · its DNA. Eukaryotic cells have evolved multifaceted responses to repair DNA damage as failure to repair these lesions may result in mutations,

DNA DAMAGE Damage_RSDFY20-863… · its DNA. Eukaryotic cells have evolved multifaceted responses to repair DNA damage as failure to repair these lesions may result in mutations,

Mutations and DNA Technology. What is a mutation? A mutation is a change in DNA Two types of mutations are gene mutations and chromosome mutations.

Mutations and DNA Technology. What is a mutation? A mutation is a change in DNA Two types of mutations are gene mutations and chromosome mutations.

DNA, RNA, Mutations

DNA, RNA, Mutations

DNA Mutations and Repair part 2 and 3

DNA Mutations and Repair part 2 and 3

DNA damage, repair and mutations - Universiteit Leiden · 1 DNA damage, repair and mutations Harry Vrieling Introduction DNA contains the blueprint for the proper development, functioning

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