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Diseases in
Dogs
VSU Veterinary Board Exam Review
SMALL ANIMAL MEDICINE
L. M. BALALA, DVM, MSc.
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CANINE PARVOVIRUS One of the most common
and deadly viral illnessesof dogs
Affects all ages
Puppies are mostsusceptible
80% of dogs that areinfected will show nosymptoms
Severe disease, dogs candie within 48 to 72 hours
with no treatment Breeds (black and tan):
Rottweilers, DobermanPinschers, LabradorRetrievers, and Pit bull
terriers are moresusceptible
Risk factors: Stressful environment
Concurrent infections withbacteria, parasites, and
canine coronavirus
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1. Intestinal form
Oral contact with CPV in feces, infected soil,
or fomites carrying the virus
Virus replicates in the lymphoid tissue in the throat and
spreads to the bloodstream Virus attacks rapidly dividing cells, notably those in the
lymph nodes, intestinal crypts, and the bone marrow
Depletion oflymphocytes in lymph nodes and necrosisand destruction of the intestinal crypts
Bacteria intestines cross into the bloodstream and causesepsis
3 to 4 post-infection: virus is shed in the feces for up tothree weeks, the dog may remain an asymptomaticcarrier and shed the virus periodically
Two forms:
http://en.wikipedia.org/wiki/Lymph_nodehttp://en.wikipedia.org/w/index.php?title=Intestinal_crypts&action=edit&redlink=1http://en.wikipedia.org/wiki/Bone_marrowhttp://en.wikipedia.org/wiki/Lymphocytehttp://en.wikipedia.org/wiki/Necrosishttp://en.wikipedia.org/wiki/Sepsishttp://en.wikipedia.org/wiki/Sepsishttp://en.wikipedia.org/wiki/Necrosishttp://en.wikipedia.org/wiki/Lymphocytehttp://en.wikipedia.org/wiki/Bone_marrowhttp://en.wikipedia.org/w/index.php?title=Intestinal_crypts&action=edit&redlink=1http://en.wikipedia.org/wiki/Lymph_node -
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2. Cardiac form
Less common, affects puppies infected in utero orshortly after birth until about 8 weeks of age
Virus attacks the heart muscle and the puppy often dies
suddenly or after a brief period of breathing difficulty At microscopic level, points of necrosis of the heart
muscle are visible alongside with mononuclear cellularinfiltrate
Formation of excess fibrous tissue (fibrosis) is often
evident in surviving dogs Myofibers are the site of viral replication within cells
May or may not be accompanied with the signs andsymptoms of the intestinal form
http://en.wikipedia.org/wiki/Fibrosishttp://en.wikipedia.org/wiki/Myofiberhttp://en.wikipedia.org/wiki/Myofiberhttp://en.wikipedia.org/wiki/Fibrosis -
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Signs and Symptoms
Dogs that develop the disease show symptoms of theillness within 3 to 10 days
Lethargy, fever, vomiting, and diarrhea (usually bloody)
dehydration and anemia Distinct odor of the feces in the later stages of the
infestation
White blood cell level drops further weakening the dog
Any or all of these factors can lead to shock and death
http://en.wikipedia.org/wiki/Doghttp://en.wikipedia.org/wiki/Shock_%28medical%29http://en.wikipedia.org/wiki/Shock_%28medical%29http://en.wikipedia.org/wiki/Dog -
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Diagnosis
Detection of CPV in the feces: ELISA
Hemagglutination test
Electron microscopy
Differential diagnoses: Coronavirus
Enteritis
Parvovirus is more serious and the presence of bloody
diarrhea, a low white blood cell count, and necrosis ofthe intestinal lining are indicative of parvovirus,especially in an unvaccinated dog
http://en.wikipedia.org/wiki/Hemagglutinationhttp://en.wikipedia.org/wiki/Electron_microscopyhttp://en.wikipedia.org/wiki/Coronavirushttp://en.wikipedia.org/wiki/Enteritishttp://en.wikipedia.org/wiki/Diarrheahttp://en.wikipedia.org/wiki/White_blood_cellhttp://en.wikipedia.org/wiki/Necrosishttp://en.wikipedia.org/wiki/Necrosishttp://en.wikipedia.org/wiki/White_blood_cellhttp://en.wikipedia.org/wiki/Diarrheahttp://en.wikipedia.org/wiki/Enteritishttp://en.wikipedia.org/wiki/Coronavirushttp://en.wikipedia.org/wiki/Electron_microscopyhttp://en.wikipedia.org/wiki/Hemagglutination -
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Treatment Early diagnosis is important for successful treatment
Extensive hospitalization due to the severe dehydrationand damage to the intestines and bone marrow
IV fluids and colloids with appropriate B-complexvitamins, dextrose and potassium chloride
antinausea injections (antiemetics) such as
metoclopramide, dolasteron, ondansetron andprochlorpromazine
antibiotic injections such as cefoxitin, metronidazole,timentin, orenrofloxacin
Analgesics such as buprenorphine are also used to
counteract intestinal discomfort Once the dog can keep fluids down, the IV fluids are
gradually discontinued, and very bland food slowlyintroduced
Oral antibiotics are administered for a number of days
depending on the white blood cell count and the patient'sability to fight off secondary infection
http://en.wikipedia.org/wiki/Intravenous_therapyhttp://en.wikipedia.org/wiki/Colloidhttp://en.wikipedia.org/wiki/B_vitaminshttp://en.wikipedia.org/wiki/B_vitaminshttp://en.wikipedia.org/wiki/Dextrosehttp://en.wikipedia.org/wiki/Antiemetichttp://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/w/index.php?title=Dolasteron&action=edit&redlink=1http://en.wikipedia.org/wiki/Ondansetronhttp://en.wikipedia.org/w/index.php?title=Prochlorpromazine&action=edit&redlink=1http://en.wikipedia.org/wiki/Antibiotichttp://en.wikipedia.org/wiki/Cefoxitinhttp://en.wikipedia.org/wiki/Metronidazolehttp://en.wikipedia.org/wiki/Timentinhttp://en.wikipedia.org/wiki/Enrofloxacinhttp://en.wikipedia.org/wiki/Enrofloxacinhttp://en.wikipedia.org/wiki/Timentinhttp://en.wikipedia.org/wiki/Metronidazolehttp://en.wikipedia.org/wiki/Cefoxitinhttp://en.wikipedia.org/wiki/Antibiotichttp://en.wikipedia.org/w/index.php?title=Prochlorpromazine&action=edit&redlink=1http://en.wikipedia.org/wiki/Ondansetronhttp://en.wikipedia.org/w/index.php?title=Dolasteron&action=edit&redlink=1http://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/wiki/Antiemetichttp://en.wikipedia.org/wiki/Dextrosehttp://en.wikipedia.org/wiki/B_vitaminshttp://en.wikipedia.org/wiki/B_vitaminshttp://en.wikipedia.org/wiki/B_vitaminshttp://en.wikipedia.org/wiki/B_vitaminshttp://en.wikipedia.org/wiki/Colloidhttp://en.wikipedia.org/wiki/Intravenous_therapy -
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Prevention and Decontamination
Prevention is the only wayto ensure that a puppy ordog remains healthy sincethe disease is extremelyvirulent and contagious
Household bleach kills thevirus is bleach
Vaccinate puppies andadult dogs against CPV]
Recovered dog is stillcontagious for up to 2months
http://en.wikipedia.org/wiki/Virulenthttp://en.wikipedia.org/wiki/Contagioushttp://en.wikipedia.org/wiki/Bleachhttp://en.wikipedia.org/wiki/Vaccinationhttp://en.wikipedia.org/wiki/Vaccinationhttp://en.wikipedia.org/wiki/Bleachhttp://en.wikipedia.org/wiki/Contagioushttp://en.wikipedia.org/wiki/Virulent -
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Dog is recovering from some
extensive damage of intestinal tract
stool may be a little loose at first
or for no stool is passed for a few days as the tractrecovers
The dog may be ravenously hungry after going so longwithout food
Do not allow the dog to gorge as this can result in
vomiting or diarrhea Feed smaller meals separated by at least an hour or
two
Do not feed table scraps; a home cooked diet may berecommended (such as boiled chicken and white rice,
or fat free cottage cheese and pasta)
Diet
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CANINE DISTEMPER
Greatest single disease threat to the worlds dogpopulation
Fatal to 80% of the puppies and 50% of the adult
dogs Through the air, by direct contact
with urine, feces, or secretions from
infected dogs, and by contact withkennels, bedding, toys, or other objects that may
hold the virus Most distemper cases appear in dogs less than six
months of age and in old dogs that have not beenroutinely vaccinated
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The virus is attacking
interfaces of the body
with the environment
(mucous membranes)
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Mucosal phase
Virus is attacking interfaces of the body withthe environment (the mucous membranes inGI and respiratory tracts)
Congested lungs, nasal discharge, gunkyeyes, coughing, weight loss, vomiting, anddiarrhea
Callusing of the nose and foot pads (hence
one of the old names for distemperhardpad disease
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Neurologic phase
Seizures
Snapping or tremoring of the jaws -chewing gum fit
Tremors, imbalance, and limb
weakness
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Treatment
Once the dog is infected, there is no cure
Supportive treatment: fluids
Recovered Dogs: hardened foot pads and nose leathers
vision and nervous system problems
throughout their lives
Puppies may have mottled teeth from
damage to developing enamel
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Vaccination
Prevention
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Infectious Canine Hepatitis
Virus enters the bloodstream and targets the liver, kidneys,
eyes, and the cells lining the inner surface of the bloodvessels. IP: 4-7 days
Some cases barely show symptoms; puppies may have aslight fever or be slightly lethargic and recover quickly
Some cases are quick and deadly; puppies show fever,tonsillitis, reddened mouth and eye membranes, colic, thenshock and death, sometimes within 24 hours.
loss of appetite, weakness, eye and nasal discharges and acough. Later gums and other mucus membranes may turn
yellow and death can occur Corneal edema edema of all bladder wall
Canine adenovirus type 1 or CAV-1
Inhalation or ingestion of virus
Signs and symptoms
Feces, urine, saliva, nasal discharge
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Diagnosis, Treatment and Prevention
DIAGNOSIS Clinical signs, hematology
TREATMENT: Intense IV fluid therapy, intensive nutritional support,
antibiotics and other medications to sustain liverhealing
PREVENTION: Vaccination
Vaccine combination with modified CAV-2 (respiratoryinfections, immunity to CAV-1 and CAV-2, less sideeffects)
Disinfection Steam cleaning and quaternary ammonium compounds
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Rabies
Lyssavirus, rhabdoviridae
Bite of another infected animal
Other routes are possible
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Signs and Symptoms1. Prodromal phase
Characterized by behavioral changes and usually lastsfor 2-3 days in dogs
Apprehension, nervousness, anxiety, solitude, and afever
Friendly animals may become shy or irritable and maysnap
Aggressive animals may become affectionate and docile
Constantly lick the site of the bite
In cats, the prodromal phase lasts for only 1-2 days and
they usually develop more fever spikes and erraticbehavior than dogs
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2. Furious phase
Prodromal phase furious stage
Cats are particularly prone todeveloping this phase
Lasts for 1 to 7 days
Restless and irritable and are
hyperresponsive to auditory andvisual stimuli
As they become more restless,they begin to roam and becomemore irritable and vicious
Caged dogs may bite and attacktheir enclosures
Disoriented and then haveseizures and eventually die
http://upload.wikimedia.org/wikipedia/commons/9/90/Rabid_dog.jpg -
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3. Paralytic (dumb) phase
Develop either after the
prodromal or furious stage andwithin 2 to 4 days after the firstsigns are noted
Nerves affecting the head andthroat are the first to be
involved and animals maybegin to salivate as a result oftheir inability to swallow
Deep labored breathing
Dropped jaw due to paralysis
in the diaphragm and facemuscles
Animals may make a chokingsound
Death is due to respiratory
failure
http://en.wikipedia.org/wiki/Image:Dog_with_rabies.jpg -
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http://en.wikipedia.org/wiki/Image:Rabies_patient.jpghttp://www.heartwormsociety.org/article.asp?id=27 -
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DIAGNOSIS
Submit the brain for
microscopic exam
FAT
Treatment
There is no treatment Vaccination
http://www.heartwormsociety.org/article.asp?id=27 -
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CORONAVIRUS INFECTION
A common and contagious viral illness to
dogs that can cause disease by itself oralong with canine parvovirus
Symptoms include vomiting,
smelly diarrhea, inappetence and weight
loss
Canine coronavirus
Direct contact with an infected animal
or its feces
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Treatment and Prevention
IV fluids, antibiotics and general supportive care
Vaccine is available but not considered tooimportant
INFECTIOUS TRACHEOBRONCHITIS
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INFECTIOUS TRACHEOBRONCHITIS
Kennel cough
Respiratory disease in dogs covers the actions ofseveral infectious agents:
Bordatella bronchiseptica
canine adenovirus-2
canine parainfluenza virus
Kennel cough agents are highly contagious, especially inkennels or shelters where canine immune systems arestressed
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Symptoms includebronchitis, eye andnasal discharges anda loud, harsh, hacking
cough
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Diagnosis and Treatment
Labs: elevated liver enzymes, jaundice,pneumonia, and intestinal inflammation
Serology, dark field microscopy
Antibiotic therapy is effective in fighting thebacterial invasion and supportive nursing
Replenishment of fluids
Administration of diuretics to flush the kidneysand prevent kidney failure
Blood transfusions if necessary
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Lyme Disease
Caused by a bacteria
that is transmitted to
dogs by ticks
Borrelia burgdorferi
Deer tick: Ixodes scapularis
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Signs and Symptoms
Lethargy, joint pain,
lameness, lack of
appetite, lymph node
enlargement, and fever More serious for humans
than for dogs
Erythema migrans:
The characteristic skin rash shown
by humans shortly after Borrelia
burgdorferi infection
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Sarcoptic Mites and Mange
SARCOPTIC MITES and DEMODEX MITESare often referred to as MANGE
Demodex mites are less troublesome thanSarcoptic mites, cause less itching and self-
mutilation, and are not seen in adult dogs asoften as Sarcoptic mites
http://www.thepetcenter.com/exa/dem.htmlhttp://www.thepetcenter.com/exa/dem.html -
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Demodex in the Dog Mange
Common infestation of the dogs skin withtiny, cigar-shaped, eight-legged mites.
Mites reside and feed in the hair follicleand oil glands of the skin
Most cases are self-limiting, the animal isable to arrest the reproduction and growthof the mites and eventually repair thedamage they do
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Once eliminated, most dogs do notacquire another infestation Immune defenses are primed to eliminate any
new Demodex mites
Small numbers of Demodex mites residingin the skin
Skin lesions due to infestations appear
when immune related, or nutritional orenvironmental stresses impact the dog
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Demodex canis
http://www.thepetcenter.com/exa/dem_skin1.jpghttp://www.thepetcenter.com/exa/demodex_019.jpg -
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Diagnosis
Demodex mitesusually createirregularly shaped,mildly irritated areas
of hair loss Skin is usually not
inflamed and lesionsare not highly pruritic
Microscopic exam ofskin scraping
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Sarcoptic Mange or scabies
Highly communicable littlebugs that dig tiny tunnelsinto the skin and causeintense itching,
inflammation and hair loss Intense itching results in
self trauma, hair loss, anddry crusty skin lesions
Often misdiagnosed asAllergic dermatitis Sarcoptes scabieivar. canis
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Misdiagnosis: Allergic Dermatitis
Common treatment: cortisone (Prednisone) Antipruritis
Immunosuppressive Enhance reproduction of Sarcoptes
They are elusive to find with skin scrapings
http://www.thepetcenter.com/exa/mites4.jpg -
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Treatment Ivermectin!
IN THE CORRECT DOSE, can successfully treatdogs for sarcoptic mites
Disadvantage: Some dogs are sensitive toIvermectin
MDR1 gene Abnormal neurologic signs
Collies, Australian Shepherds, Old English Sheepdogs,German Shepherds, Long-haired Whippets, SilkenWindhounds, and a variety of mixed breed dogs
Options: Insecticide dips and sprays
Revolution
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NORMAL RANGES FOR HEMOSTATIC VALUES... for dogs and cats
DOGS CATSBleeding Time in
minutes 2- 5 minutes
Bleeding Time in
minutes 2 - 5 minutes
Whole Blood Coag.
Time in Glass 6 - 8 minutes
Whole Blood Coag.
Time in Glass 8 minutes
Prothrombin Time 6 - 10 seconds Prothrombin Time 8.6 seconds
Partial
thromboplastin time 15 - 25 seconds
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CANINE
Vaccinati
onProtocol
Neonates* Puppy Series
Last
PuppyBooster
First
AdultBooster
Adult
Boosters
Vaccines2-6
weeks
6-8
weeks
10-12
weeks
13-16
weeks16 weeks 15 mts. Annually
Every 3
years
Distem
per/Measles
Killed
Parvo
virus
Distem
per
#
Canine
Adeno
virus
Type 2
#
VACCINATION GUIDE
CANINE
-
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CANINE
Vaccinati
on
Protocol
Neonates* Puppy Series
Last
Puppy
Booster
First
Adult
Booster
Adult
Boosters
Vaccines 2-6weeks 6-8weeks 10-12weeks 13-16weeks 16 weeks 15 mts. Annually Every 3years
Canine
Para
influenza
#
Canine
Parvo
virus
Leptosp
ira
four sero
vars
#
Rabies
Virus
Bordetell
a
(optional)
Lyme
(optional)
#: Optional; usually present in combination vaccines together with canine Parvovirus.
I diLarge
H k T Whi H t N d
Safe
D iMin.
-
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Ingredie
nts
g
Round-
worms
Hook-
worms
Tape-
worms
Whip-
worms
Heart-
worms
Need
RX
During
Preg-
nancy
Age/
Weight
Prowor
mer2
Pyrantel
pamoateX X 2 wks
NemexT
M-2
Pyrantel
pamoateX X 2 wks
D-
WormTM
Tapewor
m
Praziqua
ntelX X 4 wks
Droncit
Praziqua
ntelX X X 4 wks
Drontal
Plus
Praziqua
ntel,
Pyrantel
pamoate
,
Fenbend
azole
X X X X X3 wks
& 2 lbs
LargeSafe
Min
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Panacur
Fenbend
azoleX X X** X X X None
Heartgar
d
Plus
Ivermecti
n,
Pyrantel
pamoate
X X X X X 6 wks
Heartgard
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Ivermectin
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Heartgar
d
Chewabl
es
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nX X X 6 wks
Intercep
tor
Milbemy
cin
oxime
X X+ X X X X4 wks
& 2 lbs
Revoluti
on++
Selamec
tinX X X 6 wks
Ingredie
nts
Large
Round-
worms
Hook-
worms
Tape-
worms
Whip-
worms
Heart-
worms
Need
RX
During
Preg-
nancy
Min.
Age/
Weight
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7/27/2019 Diseases in dogs.ppt
54/54