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    Diseases in

    Dogs

    VSU Veterinary Board Exam Review

    SMALL ANIMAL MEDICINE

    L. M. BALALA, DVM, MSc.

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    CANINE PARVOVIRUS One of the most common

    and deadly viral illnessesof dogs

    Affects all ages

    Puppies are mostsusceptible

    80% of dogs that areinfected will show nosymptoms

    Severe disease, dogs candie within 48 to 72 hours

    with no treatment Breeds (black and tan):

    Rottweilers, DobermanPinschers, LabradorRetrievers, and Pit bull

    terriers are moresusceptible

    Risk factors: Stressful environment

    Concurrent infections withbacteria, parasites, and

    canine coronavirus

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    1. Intestinal form

    Oral contact with CPV in feces, infected soil,

    or fomites carrying the virus

    Virus replicates in the lymphoid tissue in the throat and

    spreads to the bloodstream Virus attacks rapidly dividing cells, notably those in the

    lymph nodes, intestinal crypts, and the bone marrow

    Depletion oflymphocytes in lymph nodes and necrosisand destruction of the intestinal crypts

    Bacteria intestines cross into the bloodstream and causesepsis

    3 to 4 post-infection: virus is shed in the feces for up tothree weeks, the dog may remain an asymptomaticcarrier and shed the virus periodically

    Two forms:

    http://en.wikipedia.org/wiki/Lymph_nodehttp://en.wikipedia.org/w/index.php?title=Intestinal_crypts&action=edit&redlink=1http://en.wikipedia.org/wiki/Bone_marrowhttp://en.wikipedia.org/wiki/Lymphocytehttp://en.wikipedia.org/wiki/Necrosishttp://en.wikipedia.org/wiki/Sepsishttp://en.wikipedia.org/wiki/Sepsishttp://en.wikipedia.org/wiki/Necrosishttp://en.wikipedia.org/wiki/Lymphocytehttp://en.wikipedia.org/wiki/Bone_marrowhttp://en.wikipedia.org/w/index.php?title=Intestinal_crypts&action=edit&redlink=1http://en.wikipedia.org/wiki/Lymph_node
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    2. Cardiac form

    Less common, affects puppies infected in utero orshortly after birth until about 8 weeks of age

    Virus attacks the heart muscle and the puppy often dies

    suddenly or after a brief period of breathing difficulty At microscopic level, points of necrosis of the heart

    muscle are visible alongside with mononuclear cellularinfiltrate

    Formation of excess fibrous tissue (fibrosis) is often

    evident in surviving dogs Myofibers are the site of viral replication within cells

    May or may not be accompanied with the signs andsymptoms of the intestinal form

    http://en.wikipedia.org/wiki/Fibrosishttp://en.wikipedia.org/wiki/Myofiberhttp://en.wikipedia.org/wiki/Myofiberhttp://en.wikipedia.org/wiki/Fibrosis
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    Signs and Symptoms

    Dogs that develop the disease show symptoms of theillness within 3 to 10 days

    Lethargy, fever, vomiting, and diarrhea (usually bloody)

    dehydration and anemia Distinct odor of the feces in the later stages of the

    infestation

    White blood cell level drops further weakening the dog

    Any or all of these factors can lead to shock and death

    http://en.wikipedia.org/wiki/Doghttp://en.wikipedia.org/wiki/Shock_%28medical%29http://en.wikipedia.org/wiki/Shock_%28medical%29http://en.wikipedia.org/wiki/Dog
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    Diagnosis

    Detection of CPV in the feces: ELISA

    Hemagglutination test

    Electron microscopy

    Differential diagnoses: Coronavirus

    Enteritis

    Parvovirus is more serious and the presence of bloody

    diarrhea, a low white blood cell count, and necrosis ofthe intestinal lining are indicative of parvovirus,especially in an unvaccinated dog

    http://en.wikipedia.org/wiki/Hemagglutinationhttp://en.wikipedia.org/wiki/Electron_microscopyhttp://en.wikipedia.org/wiki/Coronavirushttp://en.wikipedia.org/wiki/Enteritishttp://en.wikipedia.org/wiki/Diarrheahttp://en.wikipedia.org/wiki/White_blood_cellhttp://en.wikipedia.org/wiki/Necrosishttp://en.wikipedia.org/wiki/Necrosishttp://en.wikipedia.org/wiki/White_blood_cellhttp://en.wikipedia.org/wiki/Diarrheahttp://en.wikipedia.org/wiki/Enteritishttp://en.wikipedia.org/wiki/Coronavirushttp://en.wikipedia.org/wiki/Electron_microscopyhttp://en.wikipedia.org/wiki/Hemagglutination
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    Treatment Early diagnosis is important for successful treatment

    Extensive hospitalization due to the severe dehydrationand damage to the intestines and bone marrow

    IV fluids and colloids with appropriate B-complexvitamins, dextrose and potassium chloride

    antinausea injections (antiemetics) such as

    metoclopramide, dolasteron, ondansetron andprochlorpromazine

    antibiotic injections such as cefoxitin, metronidazole,timentin, orenrofloxacin

    Analgesics such as buprenorphine are also used to

    counteract intestinal discomfort Once the dog can keep fluids down, the IV fluids are

    gradually discontinued, and very bland food slowlyintroduced

    Oral antibiotics are administered for a number of days

    depending on the white blood cell count and the patient'sability to fight off secondary infection

    http://en.wikipedia.org/wiki/Intravenous_therapyhttp://en.wikipedia.org/wiki/Colloidhttp://en.wikipedia.org/wiki/B_vitaminshttp://en.wikipedia.org/wiki/B_vitaminshttp://en.wikipedia.org/wiki/Dextrosehttp://en.wikipedia.org/wiki/Antiemetichttp://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/w/index.php?title=Dolasteron&action=edit&redlink=1http://en.wikipedia.org/wiki/Ondansetronhttp://en.wikipedia.org/w/index.php?title=Prochlorpromazine&action=edit&redlink=1http://en.wikipedia.org/wiki/Antibiotichttp://en.wikipedia.org/wiki/Cefoxitinhttp://en.wikipedia.org/wiki/Metronidazolehttp://en.wikipedia.org/wiki/Timentinhttp://en.wikipedia.org/wiki/Enrofloxacinhttp://en.wikipedia.org/wiki/Enrofloxacinhttp://en.wikipedia.org/wiki/Timentinhttp://en.wikipedia.org/wiki/Metronidazolehttp://en.wikipedia.org/wiki/Cefoxitinhttp://en.wikipedia.org/wiki/Antibiotichttp://en.wikipedia.org/w/index.php?title=Prochlorpromazine&action=edit&redlink=1http://en.wikipedia.org/wiki/Ondansetronhttp://en.wikipedia.org/w/index.php?title=Dolasteron&action=edit&redlink=1http://en.wikipedia.org/wiki/Metoclopramidehttp://en.wikipedia.org/wiki/Antiemetichttp://en.wikipedia.org/wiki/Dextrosehttp://en.wikipedia.org/wiki/B_vitaminshttp://en.wikipedia.org/wiki/B_vitaminshttp://en.wikipedia.org/wiki/B_vitaminshttp://en.wikipedia.org/wiki/B_vitaminshttp://en.wikipedia.org/wiki/Colloidhttp://en.wikipedia.org/wiki/Intravenous_therapy
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    Prevention and Decontamination

    Prevention is the only wayto ensure that a puppy ordog remains healthy sincethe disease is extremelyvirulent and contagious

    Household bleach kills thevirus is bleach

    Vaccinate puppies andadult dogs against CPV]

    Recovered dog is stillcontagious for up to 2months

    http://en.wikipedia.org/wiki/Virulenthttp://en.wikipedia.org/wiki/Contagioushttp://en.wikipedia.org/wiki/Bleachhttp://en.wikipedia.org/wiki/Vaccinationhttp://en.wikipedia.org/wiki/Vaccinationhttp://en.wikipedia.org/wiki/Bleachhttp://en.wikipedia.org/wiki/Contagioushttp://en.wikipedia.org/wiki/Virulent
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    Dog is recovering from some

    extensive damage of intestinal tract

    stool may be a little loose at first

    or for no stool is passed for a few days as the tractrecovers

    The dog may be ravenously hungry after going so longwithout food

    Do not allow the dog to gorge as this can result in

    vomiting or diarrhea Feed smaller meals separated by at least an hour or

    two

    Do not feed table scraps; a home cooked diet may berecommended (such as boiled chicken and white rice,

    or fat free cottage cheese and pasta)

    Diet

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    CANINE DISTEMPER

    Greatest single disease threat to the worlds dogpopulation

    Fatal to 80% of the puppies and 50% of the adult

    dogs Through the air, by direct contact

    with urine, feces, or secretions from

    infected dogs, and by contact withkennels, bedding, toys, or other objects that may

    hold the virus Most distemper cases appear in dogs less than six

    months of age and in old dogs that have not beenroutinely vaccinated

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    The virus is attacking

    interfaces of the body

    with the environment

    (mucous membranes)

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    Mucosal phase

    Virus is attacking interfaces of the body withthe environment (the mucous membranes inGI and respiratory tracts)

    Congested lungs, nasal discharge, gunkyeyes, coughing, weight loss, vomiting, anddiarrhea

    Callusing of the nose and foot pads (hence

    one of the old names for distemperhardpad disease

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    Neurologic phase

    Seizures

    Snapping or tremoring of the jaws -chewing gum fit

    Tremors, imbalance, and limb

    weakness

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    Treatment

    Once the dog is infected, there is no cure

    Supportive treatment: fluids

    Recovered Dogs: hardened foot pads and nose leathers

    vision and nervous system problems

    throughout their lives

    Puppies may have mottled teeth from

    damage to developing enamel

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    Vaccination

    Prevention

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    Infectious Canine Hepatitis

    Virus enters the bloodstream and targets the liver, kidneys,

    eyes, and the cells lining the inner surface of the bloodvessels. IP: 4-7 days

    Some cases barely show symptoms; puppies may have aslight fever or be slightly lethargic and recover quickly

    Some cases are quick and deadly; puppies show fever,tonsillitis, reddened mouth and eye membranes, colic, thenshock and death, sometimes within 24 hours.

    loss of appetite, weakness, eye and nasal discharges and acough. Later gums and other mucus membranes may turn

    yellow and death can occur Corneal edema edema of all bladder wall

    Canine adenovirus type 1 or CAV-1

    Inhalation or ingestion of virus

    Signs and symptoms

    Feces, urine, saliva, nasal discharge

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    Diagnosis, Treatment and Prevention

    DIAGNOSIS Clinical signs, hematology

    TREATMENT: Intense IV fluid therapy, intensive nutritional support,

    antibiotics and other medications to sustain liverhealing

    PREVENTION: Vaccination

    Vaccine combination with modified CAV-2 (respiratoryinfections, immunity to CAV-1 and CAV-2, less sideeffects)

    Disinfection Steam cleaning and quaternary ammonium compounds

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    Rabies

    Lyssavirus, rhabdoviridae

    Bite of another infected animal

    Other routes are possible

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    Signs and Symptoms1. Prodromal phase

    Characterized by behavioral changes and usually lastsfor 2-3 days in dogs

    Apprehension, nervousness, anxiety, solitude, and afever

    Friendly animals may become shy or irritable and maysnap

    Aggressive animals may become affectionate and docile

    Constantly lick the site of the bite

    In cats, the prodromal phase lasts for only 1-2 days and

    they usually develop more fever spikes and erraticbehavior than dogs

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    2. Furious phase

    Prodromal phase furious stage

    Cats are particularly prone todeveloping this phase

    Lasts for 1 to 7 days

    Restless and irritable and are

    hyperresponsive to auditory andvisual stimuli

    As they become more restless,they begin to roam and becomemore irritable and vicious

    Caged dogs may bite and attacktheir enclosures

    Disoriented and then haveseizures and eventually die

    http://upload.wikimedia.org/wikipedia/commons/9/90/Rabid_dog.jpg
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    3. Paralytic (dumb) phase

    Develop either after the

    prodromal or furious stage andwithin 2 to 4 days after the firstsigns are noted

    Nerves affecting the head andthroat are the first to be

    involved and animals maybegin to salivate as a result oftheir inability to swallow

    Deep labored breathing

    Dropped jaw due to paralysis

    in the diaphragm and facemuscles

    Animals may make a chokingsound

    Death is due to respiratory

    failure

    http://en.wikipedia.org/wiki/Image:Dog_with_rabies.jpg
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    http://en.wikipedia.org/wiki/Image:Rabies_patient.jpghttp://www.heartwormsociety.org/article.asp?id=27
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    DIAGNOSIS

    Submit the brain for

    microscopic exam

    FAT

    Treatment

    There is no treatment Vaccination

    http://www.heartwormsociety.org/article.asp?id=27
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    CORONAVIRUS INFECTION

    A common and contagious viral illness to

    dogs that can cause disease by itself oralong with canine parvovirus

    Symptoms include vomiting,

    smelly diarrhea, inappetence and weight

    loss

    Canine coronavirus

    Direct contact with an infected animal

    or its feces

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    Treatment and Prevention

    IV fluids, antibiotics and general supportive care

    Vaccine is available but not considered tooimportant

    INFECTIOUS TRACHEOBRONCHITIS

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    INFECTIOUS TRACHEOBRONCHITIS

    Kennel cough

    Respiratory disease in dogs covers the actions ofseveral infectious agents:

    Bordatella bronchiseptica

    canine adenovirus-2

    canine parainfluenza virus

    Kennel cough agents are highly contagious, especially inkennels or shelters where canine immune systems arestressed

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    Symptoms includebronchitis, eye andnasal discharges anda loud, harsh, hacking

    cough

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    Diagnosis and Treatment

    Labs: elevated liver enzymes, jaundice,pneumonia, and intestinal inflammation

    Serology, dark field microscopy

    Antibiotic therapy is effective in fighting thebacterial invasion and supportive nursing

    Replenishment of fluids

    Administration of diuretics to flush the kidneysand prevent kidney failure

    Blood transfusions if necessary

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    Lyme Disease

    Caused by a bacteria

    that is transmitted to

    dogs by ticks

    Borrelia burgdorferi

    Deer tick: Ixodes scapularis

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    Signs and Symptoms

    Lethargy, joint pain,

    lameness, lack of

    appetite, lymph node

    enlargement, and fever More serious for humans

    than for dogs

    Erythema migrans:

    The characteristic skin rash shown

    by humans shortly after Borrelia

    burgdorferi infection

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    Sarcoptic Mites and Mange

    SARCOPTIC MITES and DEMODEX MITESare often referred to as MANGE

    Demodex mites are less troublesome thanSarcoptic mites, cause less itching and self-

    mutilation, and are not seen in adult dogs asoften as Sarcoptic mites

    http://www.thepetcenter.com/exa/dem.htmlhttp://www.thepetcenter.com/exa/dem.html
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    Demodex in the Dog Mange

    Common infestation of the dogs skin withtiny, cigar-shaped, eight-legged mites.

    Mites reside and feed in the hair follicleand oil glands of the skin

    Most cases are self-limiting, the animal isable to arrest the reproduction and growthof the mites and eventually repair thedamage they do

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    Once eliminated, most dogs do notacquire another infestation Immune defenses are primed to eliminate any

    new Demodex mites

    Small numbers of Demodex mites residingin the skin

    Skin lesions due to infestations appear

    when immune related, or nutritional orenvironmental stresses impact the dog

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    Demodex canis

    http://www.thepetcenter.com/exa/dem_skin1.jpghttp://www.thepetcenter.com/exa/demodex_019.jpg
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    Diagnosis

    Demodex mitesusually createirregularly shaped,mildly irritated areas

    of hair loss Skin is usually not

    inflamed and lesionsare not highly pruritic

    Microscopic exam ofskin scraping

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    Sarcoptic Mange or scabies

    Highly communicable littlebugs that dig tiny tunnelsinto the skin and causeintense itching,

    inflammation and hair loss Intense itching results in

    self trauma, hair loss, anddry crusty skin lesions

    Often misdiagnosed asAllergic dermatitis Sarcoptes scabieivar. canis

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    Misdiagnosis: Allergic Dermatitis

    Common treatment: cortisone (Prednisone) Antipruritis

    Immunosuppressive Enhance reproduction of Sarcoptes

    They are elusive to find with skin scrapings

    http://www.thepetcenter.com/exa/mites4.jpg
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    Treatment Ivermectin!

    IN THE CORRECT DOSE, can successfully treatdogs for sarcoptic mites

    Disadvantage: Some dogs are sensitive toIvermectin

    MDR1 gene Abnormal neurologic signs

    Collies, Australian Shepherds, Old English Sheepdogs,German Shepherds, Long-haired Whippets, SilkenWindhounds, and a variety of mixed breed dogs

    Options: Insecticide dips and sprays

    Revolution

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    NORMAL RANGES FOR HEMOSTATIC VALUES... for dogs and cats

    DOGS CATSBleeding Time in

    minutes 2- 5 minutes

    Bleeding Time in

    minutes 2 - 5 minutes

    Whole Blood Coag.

    Time in Glass 6 - 8 minutes

    Whole Blood Coag.

    Time in Glass 8 minutes

    Prothrombin Time 6 - 10 seconds Prothrombin Time 8.6 seconds

    Partial

    thromboplastin time 15 - 25 seconds

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    CANINE

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    Neonates* Puppy Series

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    VACCINATION GUIDE

    CANINE

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    CANINE

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    & 2 lbs

    Revoluti

    on++

    Selamec

    tinX X X 6 wks

    Ingredie

    nts

    Large

    Round-

    worms

    Hook-

    worms

    Tape-

    worms

    Whip-

    worms

    Heart-

    worms

    Need

    RX

    During

    Preg-

    nancy

    Min.

    Age/

    Weight

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