May 10, 2018

Franck Mauvais-Jarvis, M.D., Ph.D.

PERSONAL INFORMATION Name: Franck Mauvais-Jarvis, M.D., Ph.D. Address: Business address:

Division of Endocrinology & Metabolism, Department of Medicine, Tulane University School of Medicine 1430 Tulane Avenue, SL53 New Orleans, LA 70112 e-mail: fmauvais@tulane.edu 504-988-5990 phone

504-988-6271 fax

Home address: 1440 Camp St. New Orleans, LA 70130

Date of Birth: March 4, 1965 Place of Birth: Paris, France Citizenship: U.S. citizen EDUCATION 1986 B.S. Paris V School of Medicine, Paris, France GRADUATE MEDICAL EDUCATION 1991 M.D. Paris V School of Medicine, Paris, France. 2002 Ph.D. Biochemistry and Molecular Biology, Paris XI School of Medicine, Paris, France. POST-DOCTORAL TRAINING Internship and Residencies: 1991 Bichat University Hospital, Paris, France 1992 Poissy General Hospital, Poissy, France Foch General Hospital, Suresnes, France 1993 Pitié-Salpétrière University Hospital, Paris, France 1994 Lariboisière University Hospital, Paris, France Clinical and Research Fellowships 1994-1996 Clinical Fellow in Endocrinology, Lariboisiere University Hospital, Paris, France Cochin University Hospital, Paris, France Saint-Antoine University Hospital, Paris, France Necker University Hospital, Paris, France 1996-1999 Research Fellow in Medicine, Joslin Diabetes Center, Section on

Molecular & Cellular Physiology (Mentor: C. Ronald Kahn MD), 1996-1999 Research Fellow in Medicine, Harvard Medical School

May 10, 2018 BOARD CERTIFICATION and MEDICAL LICENSURE 1996 French Board of Medicine, subspecialty certification in

Endocrinology and Metabolism. 2003-2006 Texas Temporary License# 40640 2014- Louisiana License# MD.207584 FACULTY APPOINTMENTS Academic Appointments 1999-2001 Instructor in Medicine, University of Paris VII School of Medicine 2000-2003 Instructor (joint Appointment), Department of Endocrinology,

Cochin Institute of Molecular Genetics, Paris France 2001-2003 Assistant Professor of Medicine, University of Paris VII School of Medicine 2003-2006 Assistant Professor, Department of Medicine, Division of Diabetes, Endocrinology & Metabolism, Baylor College of Medicine, Houston, TX 2003-2006 Assistant Professor, Department of Molecular & Cellular Biology (joint appointment), Baylor College of Medicine, Houston, TX

2006-2013 Associate Professor, Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 2013- Present Price-Goldsmith Professor of Nutrition Research, Tulane University School of Medicine, New Orleans, LA

Professor of Medicine, Division of Endocrinology and Metabolism, Tulane University School of Medicine, New Orleans, LA

2014- Present Adjunct Professor of Pharmacology, Tulane University School of Medicine, New Orleans, LA

HOSPITAL APPOINTMENTS 1999-2001 Staff Physician, Department of Medicine, Division of Endocrinology, Lariboisiere University Hospital, Paris, France 2001-2003 Attending Physician, Division of Diabetes and Endocrinology, Saint-Louis University Hospital, Paris, France 2003-2006 Attending Physician, Endocrine Service,

Ben Taub General Hospital, Houston TX 2016- Present Staff Physician (Endocrinologist), Medicine Service, Southeast Louisiana Veterans Health Care System, New Orleans, LA ADMINISTRATIVE APPOINTMENTS 2007- 2013 Research Director, Northwestern Comprehensive Center on

Obesity (NCCO) 2009-2012 Director, Rodent Metabolic Phenotyping Core, NCCO 2013- Present Director, Tulane Diabetes Research Program COMMITTEE SERVICE Feinberg School of Medicine, Northwestern University 2008- 2013 Member, NCCO Steering Committee 2008 Committee Member, FSM Mouse Colony Management Core 2009 Committee Member, FSM Core Facility Review Panel

May 10, 2018 Tulane University School of Medicine 2013 Vision 2020 Research Strategic Planning committee, member 2014- Present Department of Medicine, Promotions and Tenure Committee, member 2015- Present School of Medicine, Grievance Committee, member 2016-Present Department of Medicine, Research Advisory Counsel, member 2018-Present LACaTS Scholar Review Committee AWARDS, HONORS and DISTINCTIONS 1994 Endocrine Fellow Research Award (French Medical Research Foundation, FRM) 1996 Silver Medal, Paris V Medical School for Medical Thesis 2000 Keystone Symposia Scholarship 2000 Raymond Berger Foundation Award (French Diabetes Association) 2000 Bristol-Myers-Squibb Research Award (France) 2002 High Honors, Paris XII Medical School for Ph.D. Thesis 2001 French Diabetes Association Junior Faculty Award 2003 Merck-Lipha Research Award (France) 2003 Lilly Research Award (France) 2004 Carolyn Weiss Law Award in Molecular Medicine (Baylor College of Medicine) 2005 Chao Scholars Award (Baylor College of Medicine) 2009 Institute for Women's Health Research Pioneer Award (Northwestern University) 2010 American Society for Clinical Investigation, Elected Member 2014 Southern Society for Clinical Investigation, Elected Member 2016 Chairman’s Award for Excellence in Research (Tulane University School of Medicine) 2016 Distinguished Reviewer Award, American Diabetes Association Journals 2018 Alpha Omega Alpha, Honor Medical Society, Elected faculty member PROFESSIONAL SOCIETY MEMBERSHIPS 2000-present French Diabetes Association (Société Française du Diabète) 2001-present French Endocrine Society (Société Française d’Endocrinologie) 2002-present Endocrine Society 2003-present American Diabetes Association 2010-Present American Society for Clinical Investigation 2015-Present Organization for the Study of Sex Differences PROFESSIONAL and SCIENTIFIC SERVICE 2004-2006 - Director: Diabetes & Endocrinology Workshop, Baylor College of Medicine 2005-2006 - Member, Texas Gulf Coast Digestive Diseases Center - Member, Admissions Committee and Training Faculty, Graduate Program in Cellular & Molecular Biology, Baylor College of Medicine - Member, Admissions Committee and Training Faculty, Graduate Program in Translational Biology & Molecular Medicine, Baylor College of Medicine - Member, Standing Examination Committee, Graduate Program in Cellular & Molecular Biology, Baylor College of Medicine - Member, Qualifying Examination Committee, Graduate Program in Cellular & Molecular Biology, Baylor College of Medicine 2005 - Emergency medical relief team for acute diabetes management

following hurricane Katrina. Houston Astrodome 2007 - Co-chair: Oral abstract session "Regulation of Pancreatic Beta-Cell Proliferation, Survival & Function". Endocrine Society 89th Meeting. Toronto, Canada 2006-2007 - Director, Reproduction and Metabolism Workshop, Northwestern University

May 10, 2018 2006-2013 - Admissions Committee and Training Faculty, Integrated

Graduate Program, Feinberg School of Medicine, Northwestern University

2007-2013 - Admissions Committee and Training Faculty, Medical Scientist Training Program,Feinberg School of Medicine, Northwestern

University - Member, Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University

- Member, Center for Reproductive Sciences, Feinberg School of Medicine, Northwestern University

- Member, Lurie Cancer Center, Feinberg School of Medicine, Northwestern University 2007 - Development of the Internal Grant Review, Department of Medicine, Feinberg School of Medicine, Northwestern University 2007-2013 - Associate Director, Endocrinology, Diabetes and Hormone action Training Grant T32 DK007169 2008-2013 - Research Director, Northwestern Comprehensive Center on

Obesity, Feinberg School of Medicine, Northwestern University 2009-2012 - Director, Rodent Metabolic Phenotyping Core, Feinberg School of

Medicine, Northwestern University 2011 - Expert panel member and session chair, National Toxicology Program/NIHES workshop. Environmental chemicals in the development of diabetes and obesity 2013 - Reviewer, Northwestern Cancer Center and Center for Genetic Medicine Travel Scholarship Program -Moderator and poster reviewer, Midwest Islet Club Meeting. Madison, WI -Chair, Oral abstracts session "Systemic Regulation of Islet

Development & Function". Endocrine Society 95th Meeting. San Francisco

Chair, Oral abstract session "GI peptides, beta-cells and glycemia". Endocrine Society 95th Meeting. San Francisco

2014 - Abstract reviewer, American Diabetes Association Meeting - Oral abstract judge, Midwest Islet Club Meeting, Birmigham, AL - Chair, Oral abstract session "Neuroscience of human obesity".

Endocrine Society 96th Meeting. Chicago. - Chair, Poster session "Central regulation of energy homeostasis".

Endocrine Society 96th Meeting. Chicago. - Chair, Symposia "the Yin and Yang of estrogen signaling in the control

of energy homeostasis". Endocrine Society 96th Meeting. Chicago. 2014-Present - Internal advisory board member, Pennington Biomedical Research

Center NORC 2016 - Chair, Symposia on “Nuclear Receptors in Energy Homeostasis”,

Endocrine Society 97th Meeting. Boston - Chair, Oral abstracts session on “Control of Glucose Homeostasis and

Dysregulation in Diabetes”. Endocrine Society 97th Meeting. Boston. - Chair, Session on “metabolic syndrome”. Nutrition and Physical Activity. Annual Meeting. Seoul National University, Korea.

2017 - Scientific Organizer. Keystone Symposia on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity”.

- Chair, Symposia on “Chemical Modulation of Beta-Cell Function”. American Diabetes Association 77th Scientific Sessions, San Diego

- Abstract reviewer, Endocrine Society 2018 meeting 2018 - Abstract reviewer, American Diabetes Association's 78th

May 10, 2018 Scientific Sessions 2018 - Scientific Review Committee, LACaTS Roadmap Scholarship applications.2019 - Scientific Co-Organizer. FASEB Summer research conference “Rapid Signaling & Genomic Hormone Action in Health & Disease”. AD-HOC JOURNAL REVIEWER: Am J Physiol Endocrinol Metab, FASEB J, Cell Metab, Diabetologia, Endocrinology, J Clin Endocrinol Metab, J Clin Invest, J Cell Biol, J Endocrinol, J Steroid Biochem Mol Biol Mol, Obesity, Proc Natl Acad Sci USA, Science. EDITORIAL BOARDS 2012-2015 Endocrinology, EB member 2012-2016 Scientific Reports, Handling Editor 2012-2016 Journal of Diabetes and its Complications, EB member 2013-Present Molecular Metabolism, topic Editor 2016- Present JCI insight, consulting Editor 2016-2017 Journal of the Endocrine Society, EB member 2016-Present Journal of Diabetes and its Complications, Associate Editor 2017-Present Diabetes, EB member 2018 Molecular Metabolism, guest Editor, special issue “Sex differences in metabolism” STUDY SECTION GRANT REVIEWER 2004 NIH/NCCAM. P50 grants 2005 Wellcome Trust (UK) project grants on mechanisms of insulin resistance 2007-2017 NIH/NIDDK – Cellular Aspects of Diabetes and Obesity (CADO), ad hoc member 2007 NIH/NIDDK - Challenge Grants panel ZRG1 EMNR-C (58) – Molecular

Diabetes & Obesity 2009 NIH/NIDDK – R24 Seed Grant panel. ZDK1 GRB-W 2010-2017 NIH/NIDDK – Integrated Physiology of Obesity and Diabetes (IPOD), ad hoc member 2011 NIH/NIDDK – R24 Seed Grant panel. NIH/NIDDK – Molecular and Cellular Endocrinology (MCE) NIH/NIDDK - ZRG1 EMNR-T (02): SEP: Diabetes and Metabolism 2011-2013 Juvenile Diabetes Research Foundation (ad hoc member) NIH/NIDDK – ZDK1 GRB-S (O4) Consortium Beta-cell Death and Survival 2015-2017 American Diabetes Association Research Grant Review Committee 2016 NIH/NIDDK – R24 Grant panel ZDK1 GRB-J M2. Beta-cell Failure 2017 NIH/NIDDK – Chair, ZRG1-CADO-B(90)S Special Emphasis Panel 2017 NIH/NIDDK – ZRG1-EMNR-B(02). Cellular and Molecular Endocrinology

and Health Disparities in Disease. Special Emphasis Panel 2018-2022 NIH/NIDDK – Integrated Physiology of Obesity and Diabetes (IPOD), member ADVISORY BOARDS 2012-2016 Pfizer, Inc. Estrogen, SERMs and TSEC scientific advisory board TEACHING COURSES University of Paris VII Medical School

May 10, 2018 1999-2003 Undergraduate course in basic and clinical Endocrinology. 1999-2003 Graduate course in basic and clinical Endocrinology, Baylor College of Medicine 2004- 2006 Cellular & Molecular Biology of Disease Course on the Pathophysiology of Type 2 diabetes in human and mouse models 2004- 2006 Human & Molecular Genetics graduate Course on the

Genetics of diabetes in human and mouse models 2004- 2006 Endocrine Course for Residents, Department of Medicine Diabetes management and medications 2004 Translational Biology & Molecular Medicine Course. Rodent Models of Diabetes. Feinberg School of Medicine, Northwestern University 2010 TGS elective course on translational research. Modeling basic biology in disease processes 2010 M1 Structure- Function lectures. Lecture 103- Intermediary Metabolism I Lecture 104- Intermediary Metabolism II Tulane University School of Medicine 2014-2015 HEAL-x Diabetes Mellitus block 2014-Present Endocrine Fellows lecture – Menopausal hormone therapy Testosterone replacement therapy SEMINAR AND WORKSHOP ORGANIZER Northwestern University 2009 - 2011 Northwestern energy metabolism workshop 2009 - 2013 NCCO Seminar Series 2010 PI and host of the Pfizer visiting professorship in Obesity (C.Ronald Kahn, M.D.) Tulane University 2013-Present Program Director, Tulane Diabetes Workshop 2015 PI and recipient of the Endocrine Society Visiting

Professorship in Diabetes (Christopher Newgard, Ph.D.) MENTORING AND TRAINING Clinical Fellows: 2000. Claire Carette, M.D.. Lariboisiere Hospital, Paris, France 2001. Aline Vernier, M.D. Lariboisiere Hospital, Paris, France 2002-2003 Sabrina Fetita, M.D. St-Louis Hospital, Paris, France 2003-2004 Abu Vasudevan, M.D. Ben Taub General Hospital, Houston, TX 2004 Susan Samson, M.D. 2004, Ben Taub General Hospital, Houston, TX Mimi Hu, M.D. 2004, Ben Taub General Hospital, Houston, TX 2005 Gilbert Fareau, M.D., 2005, Ben Taub General Hospital, Houston, TX Kerem Ozer, M.D., 2005, Ben Taub General Hospital, Houston, TX 2006 La Dale Saint-Clair, MD 2006, Ben Taub General Hospital, Houston, TX 2016-2017 Aanu Sihota, MD Southeast Louisiana VA Health Care System, New Orleans, LA

Sulay Shah, MD. Southeast Louisiana VA Health Care System, New Orleans, LA 2018- James O’Hare, MD. Southeast Louisiana VA Health Care System, New Orleans, LA

Aaron Barton, MD. Southeast Louisiana VA Health Care System, New Orleans, LA Postdoctoral Fellows St-Louis Hospital, Paris, France

May 10, 2018 2001-2003 Eugene Sobngwi, MD. Awarded French Diabetes Association Post-Doctoral

Fellowship (Current position: Professor, University of Yaounde, Cameroun) Baylor College of Medicine 2003-2004 Jean-Francois Louet, PhD (Current: Group Leader, INSERM, University of Nice, France)

2004-2006 Cedric Le May, PhD. Awarded JDRF Post-Doctoral Fellowship (Current:

Group Leader, INSERM, University of Nantes, France) 2005-2006 Robert D. Ward, Ph.D Feinberg School of Medicine, Northwestern University 2006- 2011 Suhuan Liu, Ph.D (Current: Professor at The First Affiliated Hospital of Xiamen University, China) 2007- 2012 Kazunari Nohara, Ph.D (Current: Instructor at UT Health Science Center at Houston) 2007-2010 Winifred Wong, Ph.D 2010-2011 Rizwana Waraich, PhD (Current: Assistant Professor, University of Karachi, Pakistan) 2012- 2013 Jun Ho Kim, PhD (Current: Assistant Professor, Korea University, South Korea) Tulane University School of Medicine 2013 Ana Isabel Alvarez-Mercado, PhD 2013-Present Camille Allard, PhD. Awarded ADA Post-Doctoral Fellowship. 2014-2017 Beibei Xu, PhD 2014-2016 Dragana Lovre, MD. 2017-Present Taylor Fuselier, PhD Graduate students Cochin Institute of Molecular Genetics, Paris, France 2001-2003 Bertrand Cariou (Current: Professor and Chief, Endocrinology,

University Hospital of Nantes) Feinberg School of Medicine, Northwestern University 2007-2012 Joseph P. Tiano. DGP student. Funded by Endocrinology Training

Grant T32DK007169 (Current: Fellow at the FDA) 2008-2013 Guadalupe Navarro. DGP student. Funded by minority

Supplement to R01DK074970-01 and Endocrinology Training Grant T32DK007169 (Current: Post-doctoral Stanford University)

Tulane University School of Medicine 2013-Present Weiwei Xu. BMS student 2014-Present Jamie Morford, Neuroscience Program student 2015-2016 Benjamin Salven, Undergraduate student Junior Faculty Tulane University School of Medicine 2016-present: Dragana Lovre, MD. Awarded BIRCWH scholar award. Visiting Professors Feinberg School of Medicine, Northwestern University 2013 Corinne Leloup, PhD (Current: Professor, Burgundy University, France)

May 10, 2018 Tulane University School of Medicine 2016 Jean-Francois Gautier, MD (Current, Professor and Section Chief

Endocrinology, Lariboisiere Hospital and University of Paris VII, France)

Rotating students: Ruben Lastra (IGP-2007), Kirthana Ganeshan (IGP-2007), Helen Anderson (Independent studies-2007), Jesus Banuelos (IGP-2010), Vanessa Mantova (IGP-2011) Adedoyin Johnson (BMS-2013); Other Trainees: Baylor College of Medicine 2004-2005 Christina Ortega, Research Technician Min Hu, Research Associate Feinberg School of Medicine, Northwestern University 2009-2010 Surabhi Bhatt, Research Technician 2010-2013 Matthew Meyers, Research Technician Tulane University School of Medicine 2013-Present Chandra R. Tate, Medical Research Technician RESEARCH GRANTS/CONTRACTS ACTIVE: National Institutes of Health 2016-2021 1R01DK107444 (Mauvais-Jarvis, PI) Direct cost: $ 1,616,500 Repurposing estrogens to improve pancreatic islet transplantation VA Merit Review Award 2017-2021 BX003725 -01 (Mauvais-Jarvis, PI) Total cost: $ 650,000 The role of the androgen receptor in insulin secretion Boehringer Ingelheim Pharmaceuticals, Investigator Initiated Study 2016-2018 IIS2015-10460 (Mauvais-Jarvis, PI) Total cost: $ 432,461 Synergism between Linagliptin and testosterone in glucose-stimulated insulin secretion Pfizer. Investigator initiated research grant 2016-2018 (Mauvais-Jarvis, PI) Total cost: $ 350,000 Pilot study of Duavee in preventing metabolic dysfunction in postmenopausal women PENDING National Institutes of Health 2018-2023 2R01DK074970-9 (Mauvais-Jarvis, PI) Direct cost: $ 1,250,000 Targeting estrogen receptor-α to protect functional beta-cell mass in women Funded COMPLETED

May 10, 2018 American Diabetes Association Post-Doctoral Fellowship 2015-2018(Allard, PI) Total cost: $135,000 Role of estrogens in FGF21 production National Institutes of Health 2007-2017 R01DK074970 (Mauvais-Jarvis, PI) Direct cost: $ 1,616,500 Targeting estrogen receptors to protect functional beta-cell mass American Diabetes Association Basic Science Award 2013-2017 7-13-BS-101 (Mauvais-Jarvis, PI) Direct cost: $ 350,000 Role of estrogens in suppressing hyperglucagonemia in diabetes Tulane National Primate Center Pilot Research Project 2016-2017 (Mauvais-Jarvis, PI) Direct cost: $60,000 Targeted estrogen delivery to improve pancreatic islet xenotransplantation in a nonhuman primate model of diabetes Louisiana Clinical and Translational Science (LACaTS) Center Pilot Award 2015–2017 (Mauvais-Jarvis, Co-PI) Total cost: $ 66,000 Tissue selective estrogen complex to prevent metabolic dysfunction in women Société Française du Diabètes Post-Doctoral Fellowship 2013-2014 (Allard, PI) Direct cost: $ 40,000 Pfizer. Investigator initiated research grant 2012-2016 (Mauvais-Jarvis, PI) Total cost: $ 550,000 Role of Bazedoxifene in protecting post-menopausal diabetes and obesity in rodent models American Heart Association. Innovative research grant 2011-2013 11IRG5570010 (Mauvais-Jarvis, PI) Direct cost: $200,000 Role of sex chromosomes in energy homeostasis National Institutes of Health 2008-2010 Training Grant T32 DK007169 Endocrinology, Diabetes and Hormone action (Dunaif, PI) (Trainee Guadalupe Navarro) Direct cost: $70,66 National Institutes of Health 2007-2012 P50 HD044405 (Dunaif, PI) Genes, Androgens and Intrauterine Environment in PCOS

Project III (Mauvais-Jarvis, PI) Role of androgen excess in provoking oxidative stress in females Direct cost: $900,000 National Institutes of Health 2008-2010 Training Grant T32 DK007169 Endocrinology, Diabetes and hormone action (Dunaif, PI) Direct cost: $105,870 (Trainee Joseph P. Tiano) Minority Supplement to 1R01DK074970-01 2009-2011

May 10, 2018 (Trainee: Guadalupe Navarro) Direct cost: $119,500 Institute for Women’s Health Research Pioneer Award 2009-2010 (Mauvais-Jarvis, PI) Direct cost: $25,000 March of Dimes Birth Defects Foundation 2007-2010 6-FY07-678 (Mauvais-Jarvis, PI) Direct cost: $300,000 Role of the Estrogen Receptor-alpha in Birth Defects Predisposing to Obesity and Diabetes Juvenile Diabetes Research Foundation 2006-2009 1-2006-837 (Mauvais-Jarvis, PI) Direct cost: $500,000 Role of Estrogen Receptors in Human Pancreatic Islet Survival and Functionality National Institutes of Health 2004-2006 1R21 DK069362-01 (Mauvais-Jarvis, PI) $200,000 Estrogen receptor signaling in diabetes prevention Carolyn Wiess Law Award in Molecular Medicine 2004-2005 Estrogen action in diabetes prevention (Mauvais-Jarvis, PI) $25,000 TT Chao Scholar Award (Mauvais-Jarvis, PI) 2004-2006 Role of estrogen receptors modulators in pancreatic beta-cell survival $100,000 SCHOLARLY BIBLIOGRAPHY (* corresponding author) Publications (PubMed): 103 First/corresponding author: 68 (66%) h-index (Web of science): 33 h-index (Google scholar): 40 Citations (Web of science): 5059 Citations (Google scholar): 8549 Average citation/article: 43 a. Peer -reviewed research articles, reviews, letters, editorials. 1. Mauvais-Jarvis F, Bouchard P. Insulin resistance and hyperandrogenism: A common

pathophysiological mechanism? Références en Gynécologie & Obstétrique. 1995; 3:319-320. Editorial. French

2. Mauvais-Jarvis F*, Larger E, Assan R. Diabetes Mellitus in AIDS patients treated with antiretroviral nucleoside analogs. Journ Annu Diabetol Hotel Dieu.1997:43-8. Review. French.

3. Vincens M, Mauvais-Jarvis F, Behar S: A novel recognition site for somatostatin-14 on the GABA (A) receptor complex. Eur J Pharmacol 1998 Feb 26;344(1):R1-2

4. Mauvais-Jarvis F, Bertherat J, Ravaud H, Thomopoulos P, Luton JP. POEMS syndrome with primary adrenocortical insufficiency. Presse Med. 1998 Jan 10;27(1):15-7. Case report.

May 10, 2018 5. Kasus-Jacobi A, Perdereau D, Auzan C, Clauser E, Van Obberghen E, Mauvais-Jarvis F,

Girard J, Burnol AF: Identification of the rat adapter Grb14 as an inhibitor of insulin actions: J Biol Chem 1998 Oct 2;273(40):26026-35

6. Martinez M, Virally ML, Guillausseau-Scholer C, Vincenot M, Samuel-Lajeunesse J,

Mauvais-Jarvis F, Kévorkian JP, Porokhov B, Valleur P, Guillausseau PJ. High carcinoembryonic antigen level following cancer surgery: another way to detect thyroid medullary carcinoma. Rev Med Interne. 2000 Oct;21(10):897-900. Case report.

7. Kim J.K., Michael M.D, Previs S.F., Peroni O., Mauvais-Jarvis F, Neschen S., Kahn BB.,

Kahn C.R., Shulman G.I.: Redistribution of Substrates to Adipose Tissue in Mice with Selective Insulin Resistance in Muscle Promotes Obesity. J. Clin. Invest. 2000 Jun;105(12):1791-7

8. Zisman A., Perroni O., Abel E.D., Michael M.D., Mauvais-Jarvis F., Lowell B., Wojtazewski

J., Hirshman M., Virkamaki A., Goodyear L., Kahn C.R. and Kahn B.B. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat. Med. 2000 Aug; 6 (8): 924-28

9. Ueki K., Algenstaedt P., Mauvais-Jarvis F., and Kahn C.R.: Positive and Negative

Regulation of Phosphoinositide 3-kinase Dependent Signaling Pathways by Three Different Gene Products of the p85alpha Regulatory Subunit. Mol. Cell. Biol. 2000, Nov, 20(21): 8035-46.

10. Fruman D.A., Mauvais-Jarvis F., Pollard D.A., Bronson R., Kahn C.R., and Cantley L.C.:

Hypoglycemia, Hepatocellular Necrosis and Perinatal Death in Mice Lacking All Forms of Phosphoinositide 3-kinase p85 alpha. Nat.Genet. 2000. Nov; 26: 379-82.

11. Mauvais-Jarvis F., Virkamaki A., Winnay J.N., Zisman A., Kulkarni R.N., Michael M.D. and

Kahn C.R.: A Model to Study the Interaction Between Muscle Insulin Resistance and Impaired beta-cell function in the Development of Type 2 Diabetes. Diabetes. 2000. Dec;49: 2126-34

12. Mauvais-Jarvis F.*, Kahn C.R.: Understanding the Pathogenesis and Treatment of Insulin

Resistance and Type 2 Diabetes: What Can we Learn from Transgenic and Knockout Mice. Review. Diabetes Metab. 2000. Dec; 26: 433-48. (Review peer-reviewed).

13. Mauvais-Jarvis F.*, Andreelli F., Hanaire Broutin H., Girard J., Charbonnel B. : Therapeutic

Perspectives for Type 2 Diabetes Mellitus. Clinical and Molecular Insights. Diabetes Metab. 2001. 27: 415-23. (Review peer-reviewed).

14. Gautier JF, Mauvais-Jarvis F. Physical exercise and insulin sensitivity. Diabetes Metab.

2001 Apr;27(2 Pt 2):255-60. Review (Review peer-reviewed). 15. Sobngwi E., Mauvais-Jarvis F., Vexiau P., Mbanya C., Gautier J.F. Diabetes in Africans.

Part 1: Epidemiology and Clinical Specificities. Diabetes Metab. 2001.27 : 628-34. (Review peer-reviewed).

16. Mauvais-Jarvis F., Ueki K., Fruman D.A., Miller K.E., Iannacone M., Accili D., Cantley L.C.

and Kahn C.R.: Reduction in the p85 alpha Isoform of Phosphoinositide 3-Kinase Improves Insulin Signaling and Ameliorates Diabetes in Mice. J. Clin. Invest. 2002. Jan ; 109: 141-149.

May 10, 2018 17. Mauvais-Jarvis F*., Kulkarni R.N., Kahn C.R. Knockout Models Are Useful Tools to Dissect

the Pathophysiology and Genetics of Insulin Resistance. Clin Endoc. 2002 Jul;57(1):1-9. Review. (Review peer-reviewed).

18. Sobngwi E., Mauvais-Jarvis F., Vexiau P., Mbanya C., Gautier J.F. Diabetes in Africans.

Part 2: Ketosis-prone atypical diabetes mellitus. Diabetes Metab. 2002. 28: 5-12. (Review peer-reviewed).

19. Sobngwi E., Lepage V.,Vexiau P., Mauvais-Jarvis F., Leblanc, H., Levy V., Mbanya J.C.,

Gautier J.F. Metabolic and Immunogenetic Prediction of Long Term Insulin Remission In Black Africans with Atypical Diabetes. Diabetic Med. 2002; 19: 832-35.

20. Mauvais-Jarvis F*. Leptin-Replacement Therapy in Lipodystrophy. N. Engl. J. Med. 2002.

Jun; 346 (25): 2008. Letter. 21. Mauvais-Jarvis F., Sobngwi E., Porcher R., Garnier J.P., Vexiau P., Gautier J.F. Glucose

response to intense aerobic exercise in type 1 diabetes: maintenance of near euglycemia despite a drastic decrease in insulin dose. Diabetes Care. 2003 Apr; 26(4):1316-7.

22. Mauvais-Jarvis F*., Boudou P., Sobngwi E., Riveline JP., Kevorkian JP., Villette JM.,

Vexiau P., Gautier J.F., The missense mutation Gly574Ser in the transcription factor HNF-1 alpha is not a marker of ketosis-prone atypical diabetes in Afro-Caribbeans. Diabetologia. 2003. May; 46(5):728-9.

23. Sobngwi E, Boudou P, Mauvais-Jarvis F, Leblanc H, Velho G, Vexiau P, Porchet R, Pratley

R, Tataranni A, Calvo F, Gautier JF. Effect of a diabetic environment in utero on predisposition to type 2 diabetes. Lancet . 2003. May 31; 361(9372):1861-5.

24. Boudou P, Sobngwi E., Mauvais-Jarvis F, Vexiau P, Gautier JF. Absence of exercise-

induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men. Eur J Endoc. 2003 Nov;149(5):421-4.

25. Postic C, Mauvais-Jarvis F, Girard J. Mouse models of insulin resistance and type 2

diabetes. Ann Endocrinol. 2004 Feb;65(1):51-9. 26. Gautier JF, Mauvais-Jarvis F, Sobngwi E. Metabolic effects of physical activity in the type 2

diabetic subject. Journ Annu Diabetol Hotel Dieu. 2004:79-93. Review.

27. Chen D, Mauvais-Jarvis F, Bluher M, Fisher SJ, Jozsi A, Goodyear LJ, Ueki K, Kahn CR. p50 alpha /p55 alpha PI 3-kinase Knockout Mice Exhibit Enhanced Insulin Sensitivity. Mol Cell Biol. 2004 Jan;24(1):320-9.

28. Cariou B, Postic C, Boudou P, Burcelin R, Kahn CR, Girard J, Burnol AF, Mauvais-Jarvis

F*. Cellular and molecular mechanisms of adipose tissue plasticity in muscle-specific insulin receptor knockout mice. Endocrinology. 2004 Apr;145(4):1926-32.

29. Mauvais-Jarvis F*, Sobngwi E, Porcher R, Riveline JP, Kevorkian JP, Guillausseau PJ,

Charpentier G, Vexiau P, Gautier JF. Ketosis-Prone Type 2 Diabetes Mellitus in Sub-Saharan Africans: Clinical Pathophysiology and Natural History of beta-Cell Dysfunction and Insulin Resistance. Diabetes. 2004 Mar;53(3):645-53.

30. Louet JF, Le May C, Mauvais-Jarvis F*. Antidiabetic actions of estrogen: insight from human and genetic mouse models. Curr Atheroscler Rep. 2004 May;6(3):180-5. (Review peer-reviewed).

May 10, 2018 31. Mauvais-Jarvis F*, Smith SB, Le May C, Leal SM, Gautier JF, Riveline JP, Rajan AS,

Kevorkian JP, Zhang S, Vexiau P, German MS, Vaisse C. PAX4 gene variations predispose to ketosis-prone diabetes. Human Mol Genet. 2004 Dec15;13(24):3151-9.

32. Sobngwi E, Gautier JF, Kevorkian JP, Villette JM, Riveline JP, Charpentier G, Vexiau P,

Leal, SM, Vaisse C, Mauvais-Jarvis F*. High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes. J Clin Endoc Metab. 2005 Aug;90(8):4446-51.

33. Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F,Merriman

R, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, Dent R, McPherson R, Kwok PY, Hinney A, Hebebrand J,Vaisse C. Lack of Support for the Association between GAD2 Polymorphisms and Severe Human Obesity. PLoS Biol. 2005 Sep;3(9):e315. Epub 2005 Aug 30.

34. Le May C, Chu K, Hu, M, Ortega CS, Simpson ER, Korach KS, Tsai MJ, Mauvais-Jarvis F*.

Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin deficient diabetes mellitus in mice. Proc Natl Acad Sci U S A. 2006. Jun 13;103(24):9232-7.

35. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee M,

Jung DY, Zhang Z, Kim JK, Poitou C, Clement K, Mauvais-Jarvis F, Ducy P, Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007. Aug 10; 130 (2): 456–469.

36. Louet J, Smith S, Gautier JF, Molokhia M, Virally M., Kevorkian JP, Guillausseau PJ, Vexiau

P, Charpentier G, German M, Vaisse C, Urbanek M, Mauvais-Jarvis F*. Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes. Diabetes Obes Metab. 2008 Sep;10(10):912-20. Epub 2007 Dec 17.

37. Choukem SP, Sobngwi E, Fetita LS, Boudou P, De Kerviler E, Boirie Y, Hainault I, Vexiau P,

Mauvais-Jarvis F, Calvo F, Gautier JF. Multi-tissue insulin resistance despite near-normoglycemic remission in Africans with ketosis-prone diabetes. Diabetes Care. 2008 Dec;31(12):2332-7.

38. Liu S, Le May C, Wong WPS, Ward RD, Clegg DJ, Korach KS, Mauvais-Jarvis F*

Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes. 2009 Oct;58(10):2292-302. Epub 2009 Jul 8

39. Liu S, Mauvais-Jarvis F*. Rapid, nongenomic estrogen actions protect pancreatic islet

survival. Islets. 2009 Nov;1 (3): 273-75.

40. Liu S, Mauvais-Jarvis F*. Minireview: Estrogenic Protection of beta-Cell Failure in Metabolic Diseases. Endocrinology. 2010 Mar;151(3):859-64. Epub 2009 Dec 4. (Invited and peer reviewed Review).

41. Liu S, Navarro G, Mauvais-Jarvis F*. Excess androgen produces systemic oxidative stress

and predisposes to beta-cell failure in female mice. PloS One. 2010 Jun 24;5(6):e11302. 42. Wong PS, Tiano J , Liu S, Hewitt SC, Le May C, Dalle S, Katzenellenbogen JA,

Katzenellenbogen BS, Korach KS, Mauvais-Jarvis F*. The extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis. Proc Natl Acad Sci USA. 2010 Jul 20;107(29):13057-62. Epub 2010 Jun 29.

May 10, 2018

43. Mauvais-Jarvis F*. Estrogen and androgen receptors. Regulators of energy homeostasis and potential targets for diabetes and obesity. Trends Endoc Metab. 2011 Jan;22(1):24-33. Epub 2010 Nov 5 (Invited and peer reviewed Review).

44. Nohara K, Waraich R, Laque A, Tiano JP, Munsberg H, Mauvais-Jarvis F*. Early life

exposure to testosterone programs the hypothalamic melanocortin system. Endocrinology. 2011 Apr;152(4):1661-9. Epub.2011 Feb 8.

45. Tiano JP, Delghingaro-Augusto V, Le May C, Liu S, Latour MG, Fernstrom M, Bhatt SB,

Najjar SM, Korach KS, Prentki M, Mauvais-Jarvis F*. Estrogen receptors activation reduces pancreatic islet lipogenesis and prevents β-cell failure in rodent model of type-2 diabetes. J Clin Invest. 2011 Aug 1;121(8):3331-42. Epub 2011 July 11. PMID: 21747171

46. Tiano JP, Liu S, Mauvais-Jarvis F*. Importance of estrogen receptors to protect functional

beta-cell mass in diabetes. Nat Rev Endocrinol. 2012 Feb 14;8(6):342-51. PMID: 22330739.

47. Mauvais-Jarvis F*. Tribute to Pierre Mauvais-Jarvis, MD. A pioneer in the percutaneous

administration of steroid hormones. Steroids. 2012. (77): 77-78. Epub Mar 23. (Invited and peer reviewed editorial).

48. Tiano JP, Mauvais-Jarvis F*. Selective estrogen receptors activation in pancreatic β-cells

and diabetes prevention. Islets. 2012 Mar-Apr;4(2):173-6. Epub 2012 Mar 1.

49. Tiano JP, Mauvais-Jarvis F*. Molecular mechanisms of estrogen receptors suppression of lipogenesis in pancreatic β-cells. Endocrinology. 2012 Jul;153(7):2997-3005. PMID: 22564979; PMCID: PMC3380304

50. Mauvais-Jarvis F*. Estrogen sulfotransferase. Intracrinology meets metabolic diseases.

Diabetes. 2012 Jun;61(6). PMCID: PMC3357281. Comment.

51. Choukem SP, Sobngwi E, Boudou P, Fetita LS, Porcher R, Vexiau P, Mauvais-Jarvis F, Calvo F, Gautier JF. Beta and alpha cell functions in Africans with ketosis-prone diabetes during near-normoglycemic remission. Diabetes Care. 2013 Jan;36(1):118-23. Epub 2012 Aug 28. PMID: 22933436; PMCID: PMC3526247.

52. Liu S, Kilic G, Meyers, M, Navarro L, Wang Y, Oberholzer J, Mauvais-Jarvis F*.

Oestrogens improve human pancreatic islet transplantation in a model of insulin-deficient diabetes. Diabetologia. 2013 Feb;56(2):370-81. Epub 2012 Nov 7. PMID: 23132340; PMCID: PMC3536964

53. Finan B, Yang B, Ottaway N, Stemmer K, Muller TD, Yi CX, Habegger K, Schreiver SC,

Garcia Caceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, Irmler M, Beckers J, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger P, Zhang L, Gelvanov V, DiMarchi RD, Tschop MH. Targeted estrogen delivery reverses the metabolic syndrome. Nat Med. 2012 Dec 6;18(12):1847-56. Epub 2012 Nov 11. PMID: 23142820; PMCID: PMC3757949.

54. Mauvais-Jarvis F*. C-reactive protein links inflammation, endothelial dysfunction and

muscle insulin resistance. Diabetes. 2013. Mar;62(3):688-90. PMID: 23431010; PMCID: PMC3581197.

May 10, 2018 55. Mauvais-Jarvis F*, Clegg DJ, Hevener, AL. The role of estrogens in energy homeostasis

and glucose metabolism. Endocr Rev. 2013 Jun;34(3):309-38. Epub 2013 Mar 4. Review. PMID: 23460719; PMCID: PMC3660717.

56. Nohara K, Waraich RS, Liu S, Ferron M, Waget A, Meyers MS, Karsenty G, Burcelin R,

Mauvais-Jarvis F*. Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice. Am J Physiol Endocrinol Metab. 2013 Jun 15;304(12):E1321-30. Epub 2013 Apr 23. PMID: 24084835; PMCID: PMC3901078.

57. Kuttenn F, Touraine P, Mauvais-Jarvis F, Bercovici JP. [Tribute to Professor Pierre

Mauvais-Jarvis, a visionary man 1929–2012]. Ann Endocrinol (Paris). 2013Jul;74(3):163-5. French. PMID: 24040659.

58. Nohara K, Liu S, Ferron M, Waget, A, Karsenty G, Burcelin R, Mauvais-Jarvis F*.

Developmental androgen excess disrupts reproduction and energy homeostasis in male mice. J Endocrinol. 2013 Nov 6;219(3):259-68. PMID: 24084835; PMCID: PMC3901078.

59. Waraich RS, Mauvais-Jarvis F*. Paracrine and intracrine contributions of androgens and

estrogens to adipose tissue biology: physiopathological aspects. Horm Mol Biol Clin Invest. 2013 Aug;14(2):49-55. Review. PMID: 25436719.

60. Bernal-Mizrachi E, Kulkarni RN, Scott DK, Mauvais-Jarvis F, Stewart AF, Garcia-Ocaña A.

Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map. Diabetes. 2014 Mar;63(3):819-31. Review. PubMed PMID: 24556859; PMCID:PMC3931400.

61. Kilic G, Alvarez-Mercado AI, Zarrouki B, Opland D, Liew CW, Alonso LC, Myers MG Jr,

Jonas JC, Poitout V, Kulkarni RN, Mauvais-Jarvis F*. The Islet Estrogen Receptor-α Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes. PLoS One. 2014 Feb 3;9(2):e87941. PMID: 25755205; PMCID: PMC3912162.

62. Kim JH, Meyer M, Hevener AE, Najjar S, Leloup C, Mauvais-Jarvis F*. Tissue-selective

estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice. Mol Metab. 2014 Jan 9;3(2):177-90. eCollection 2014 Apr. PMID: 24634829; PMCID: PMC3953695.

63. Nohara K, Laque A, Munsberg H, Mauvais-Jarvis F*. Central mechanisms of adiposity in

adult female mice with androgen excess. Obesity. 2014 Jun;22(6):1477-84. Epub 2014 Feb 19. PMID:24639082; PMCID: PMC4037375.

64. Mauvais-Jarvis F*. Developmental androgenization programs metabolic dysfunction in

adult mice: Clinical implications. Adipocyte. 2014 Apr 1;3(2):151-4. Epub 2014 Jan 21. PMID: 24719790; PMCID: PMC3979881.

65. Mauvais-Jarvis F*. Elucidating gender and sex differences in diabetes: a necessary step

toward personalized medicine. J Diabetes Complications. 2015 Mar;29(2):162-3. Epub 2014 Nov 27. Editorial. PMID: 25543263.

66. Navarro G, Allard C, Xu W ; Mauvais-Jarvis F*. The role of the androgen receptor in

glucose homeostasis and diabetes. Obesity. 2015. Apr;23(4):713-9. Epub 2015 Mar 6. Review. PMID: 25755205; PMCID: PMC4380643.

May 10, 2018 67. Tiano JP, Tate C, Bin Y, DiMarchi R, Mauvais-Jarvis F*. Effect of targeted estrogen

delivery using glucagon-like peptide-1 on insulin secretion, insulin sensitivity and glucose homeostasis. Sci. Rep. 2015. 5, 10211;doi: 10.1038/srep10211. PMID: 25970118; PMCID: PMC4429560.

68. Hevener AL, Clegg DJ, Mauvais-Jarvis F. Impaired estrogen receptor action in the

pathogenesis of the metabolic syndrome. Cell Mol Endocrinol. 2015 Dec 15;418 Pt 3:306-21. doi: 10.1016/j.mce.2015.05.020. Epub 2015 May 29. Review. PMID: 26033249.

69. Xu, B, Lovre D, Mauvais-Jarvis F*. Role of selective estrogen receptor modulators in

metabolic homeostasis. Biochimie. 2016 May;124:92-7. doi:10.1016/j.biochi.2015.06.018. Epub 2015 Jun 29. Review. PMID: 26133657.

70. Lovre D, Mauvais-Jarvis F*.Trends in prevalence of the metabolic syndrome. JAMA. 2015

Sep 1;314(9):950. doi: 10.1001/jama.2015.8625. Letter. PMID: 26325567.

71. Choukem SP, Sobngwi E, Garnier JP, Letellier S, Mauvais-Jarvis F, Calvo F, Gautier JF Hyperglycaemia per se does not affect erythrocyte glucose-6-phosphate dehydrogenase activity in ketosis-prone diabetes. Diabetes Metab. 2015 Sep;41(4):326-30. PubMed PMID: 26337344.

72. Mauvais-Jarvis F*. Sex differences in metabolic homeostasis, diabetes and obesity. Biol

Sex Differ. 2015 Sep 3;6:14. doi: 10.1186/s13293-015-0033-y.eCollection 2015. Review. PMID: 26339468; PMCID: PMC4559072.

73. Zhang Y, Fava, GE, Wang, H, Mauvais-Jarvis F, Fonseca V, Wu H, Pax4 gene transfer

induces α to β cell phenotypic conversion and confer therapeutic benefits for diabetes treatment. Mol Ther. 2016 Feb;24(2):251-60. doi:10.1038/mt.2015.181. Epub 2015 Oct 5. PMID: 26435408; PMCID: PMC4817809.

74. Mauvais-Jarvis F*. Liraglutide and weight management. N Engl J Med. 2015 Oct

29;373(18):1779-1782. PMID: 26510030. Letter.

75. Mauvais-Jarvis F*. Letter to the Editor: "Steroid Sex Hormones, Sex Hormone-Binding Globulin, and Diabetes Incidence in the Diabetes Prevention Program" by Mather K.J., et al. J Clin Endocrinol Metab. 2015 Dec;100(12):L126-7. PMID: 27032326.

76. Mauvais-Jarvis F*. Androgen-deprivation therapy and pancreatic β-cell dysfunction in men.

J Diabetes Complications. 2016 Apr;30(3):389-90. doi:10.1016/j.jdiacomp.2016.01.007. Epub 2016 Jan 11. PMID: 26861947.

77. Mauvais-Jarvis F*. Letter to the Editor: "Dual-5α-Reductase Inhibition Promotes Hepatic

Lipid Accumulation in Man" by Hazlehurst J.M., Oprescu A.I., Nikolaou N., et al. J Clin Endocrinol Metab. 2016 Apr;101(4):L46-7. PMID: 27032326.

78. Navarro G, Xu W, Jacobson D, Verhoeven G, Zhang H, Katzenellenbogen JA, Mauvais-

Jarvis F*. Extranuclear actions of the androgen receptor enhance glucose-stimulated insulin secretion in the male. Cell Metab. 2016 May 10;23(5):837-51. Epub 2016 Apr 28. PMID: 27133133. PMCID: PMC4864089.

79. Lovre D, Lindsey S, Mauvais-Jarvis F*. Effect of menopausal estrogen therapy on

components of the metabolic syndrome. Ther Adv Cardiovasc Dis. 2016 May 27. pii: 1753944716649358. [Epub ahead of print] Review. PubMed PMID: 27234158.

May 10, 2018 80. Tong J, Mauvais-Jarvis F. The D-Day of ghrelin. Mol Metab. 2016 May 20;5(7):433-4.

PMID: 27408768; PMCID: PMC4921939. 81. Kim JH, Mauvais-Jarvis F*. The combination of conjugated equine estrogens with

bazedoxifene prevents streptozotocin-induced diabetes in ovariectomized female mice. Matters. 2016. doi:10.19185/matters.201605000017

82. Mauvais-Jarvis F*. Role of sex steroids in β–cell function, growth and survival. Trends

Endoc Metab. 2016 Dec;27(12):844-855. Epub 2016 Sep 15. PMID: 27640750; PMCID: PMC5116277. Review.

83. Mauvais-Jarvis F*. Developing academic visibility in the medical sciences. Ochsner J.

2016 Fall;16(3):208-9. PMID: 27660566; PMCID: PMC5024799. 84. Morford J, Mauvais-Jarvis F*. Sex differences in the neurobiology of androgen action on

metabolic function. Dialogues Clin Neurosci. 2016 Dec;18(4):415-424. PMID: 28179813; PMCID: PMC5286727.Review.

85. Xu B, Lovre D, Mauvais-Jarvis F*. The effect of selective estrogen receptor modulators on

type 2 diabetes onset in women: Basic and clinical insights. J Diabetes Complications. 2017 Apr;31(4):773-779. PMID: 28185712; PMCID: PMC5350049. Review.

86. Sharma G, Mauvais-Jarvis F, Prossnitz ER. Roles of G protein-coupled estrogen receptor

in metabolic regulation. J Steroid Biochem Mol Biol. 2018 Feb;176:31-37. PMID: 28223150.

87. Mauvais-Jarvis F*. Is estradiol a biomarker of type 2 diabetes risk in postmenopausal

women? Diabetes. 2016. 2017 Mar;66(3):568-570. PMID: 28223340; PMCID: PMC5319722. Commentary.

88. Pollock, B, Mauvais-Jarvis F, Bazzano L. Differential sex effects of systolic blood pressure

and LDL-C on Type 2 diabetes: Life-course data from the Bogalusa Heart Study. J Diabetes. 2017 Feb 27. doi: 10.1111/1753-0407.12543. [Epub ahead of print]. PMID: 28239958.

89. Mauvais-Jarvis F*, Manson JE, Stevenson JC, Fonseca VA. Menopausal hormone therapy

delays type 2 diabetes: Evidence, mechanisms, and clinical implications. Endocr Rev. 2017 Jun 1;38(3):173-188. PMID: 28323934.

90. Xu W, Niu T, Navarro G, Mauvais-Jarvis F*. Androgen receptor-deficient pancreatic β-cells

exhibit dysregulation of genetic markers of inflammation and insulin secretion. A transcriptome analysis in male mice. J Diabetes Complications. 2017 May;31(5):787-795. PMID: 28343791.

91. Mukerjee S, Zhu Y, Zsombok A, Mauvais-Jarvis F, Zhao J, Lazartigues E. Perinatal

Exposure to Western Diet Programs Autonomic Dysfunction in the Male Offspring. Cell Mol Neurobiol. 2017 May 6. doi: 10.1007/s10571-017-0502-4. [Epub ahead of print]. PMID: 28478572.

92. Layden BT, Wicksteed B, Mauvais-Jarvis F. Incretin-Based Therapies: Revisiting Their

Mode of Action. Endocrinology. 2017 Jun 1;158(6):1560-1563. doi: 10.1210/en.2017-00252. PMID: 28575434.

May 10, 2018 93. Song J, Yang Y, Mauvais-Jarvis F, Wang Y, Niu T. KCNJ11, ABCC8 and TCF7L2

polymorphisms and the response to sulfonylurea treatment in patients with type 2 diabetes: A bioinformatics assessment. BMC Med Genet. 2017 Jun 6;18(1):64.PMID: 28587604.

94. Mauvais-Jarvis F*, Arnold A, Reue K. A Guide for the Design of Pre-clinical Studies on Sex

Differences in Metabolism. Cell Metab. 2017 Jun 6;25(6):1216-1230. Review. PubMed PMID: 28591630; PubMed Central PMCID: PMC5516948.

95. Zang Y, Dong E, Htu W, Mauvais-Jarvis F, Fonseca V, Wu H. Differential Effects of

Linagliptin on the Function of Human Islets Isolated from Non-diabetic and Diabetic Donors. Sci Rep. 2017 Aug 11;7(1):7964. PMID: 28801559. PMCID: PMC5554162.

96. Dong S, Baranwal S, Garcia A, Serrano Gomez S, Eastlack S, Iwakuma T, Mercante D,

Mauvais-Jarvis F, Alahari SK. Inhibition of Nischarin improves energy metabolism through activation of AMP-activated protein kinase. J Biol Chem. 2017 Oct 13;292(41):16833-16846. Epub 2017 Aug 24. PMID: 28842496. PMCID: PMC5641867.

97. Mauvais-Jarvis F*. Gender differences in glucose homeostasis and diabetes. Physiol Behav. 2018 Apr 1;187:20-23. Epub 2017 Aug 24. PubMed PMID: 28843891; PubMed Central PMCID: PMC5826763.

98. Morford JJ, Wu, S, Mauvais-Jarvis F*. The impact of androgen actions in neurons on

metabolic health and disease. Mol Cell Endocrinol. 2018 Apr 15;465:92-102. Epub 2017 Sep 4. Review. PubMed PMID: 28882554; PubMed Central PMCID: PMC5835167.

99. Mauvais-Jarvis F*. Are estrogens promoting immune modulation and islet protection in type

1 diabetes. J Diabetes Complications. 2017 Nov;31(11):1563-1564. Epub 2017 Aug 3. PubMed PMID: 28890307.

100. Mauvais-Jarvis F*. New insights into estrogens inactivation and prevention of systemic

inflammation in male subjects. Endocrinology. 2017 Nov 1;158(11):3711-3712. PubMed PMID: 29099958; PubMed Central PMCID: PMC5695833.

101. Mauvais-Jarvis F*. Epidemiology of Gender Differences in Diabetes and Obesity. Adv

Exp Med Biol. 2017;1043:3-8. PubMed PMID: 29224087.

102. Mauvais-Jarvis F*. Menopause, Estrogens, and Glucose Homeostasis in Women. Adv Exp Med Biol. 2017;1043:217-225. PubMed PMID: 29224097.

103. Mauvais-Jarvis F*. Le May C, Tiano JP, Liu S, Kilic-Berkmen G, Kim JH. The Role of

Estrogens in Pancreatic Islet Physiopathology. Adv Exp Med Biol. 2017;1043:385-399. PubMed PMID: 29224104.

104. Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA,

Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. Estrogen receptor alpha protects pancreatic beta cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. J Biol Chem. 2018 Mar 30;293(13):4735-4751. Epub 2018 Jan 29. PMID: 29378845; PMCID: PMC5880140.

105. Gautier, JF, Fetita LS, Riveline JP, Chouken PS, Hadjadj S, Larger E, Roussel R, Boudou P, Marre M, Ravussin E, Mauvais-Jarvis F. Sex difference in the effect of fetal exposure to maternal diabetes on insulin secretion. J Endoc Soc. 2018 Mar 22;2(5):391-397. PMID: 29687090

May 10, 2018

106. Navarro G, Allard C, Morford JJ, Xu W, Liu S, Jacobson D, Mauvais-Jarvis F*. Androgen excess in β-cells and neurons predisposes to type 2 diabetes in female mice. JCI Insight. Accepted.

107. Li, J, Fu X, Cao S, Li J, Xing J, Li D, Dong Y, Cardin D, Park HW Mauvais-Jarvis F, Zhang

H. Membrane-associated androgen receptor activates HSP27 to potentiate its genomic actions. J Biol Chem. in Revision.

108. Gannon M, Kulkarni RN, Tse H, Mauvais-Jarvis F*. Sex and gender differences in islet cell

biology and dysfunction. Mol Metab. In preparation. 109. Xu B, Allard C, Alvarez Marcado AI, Kim JH Urano F, Korach KS, Levin ER, Arvan P, Floyd

ZE, Mauvais-Jarvis F*. Estrogens promote misfolded proinsulin degradation and prevent β cell failure in mice. Cell Rep In revision.

110. Zhang Y, Parajuli KR, Fava GE, Gupta R, Xu W, Briere DA, Nguyen LU, Zakaria A, Wang H, Fonseca VA, Mauvais-Jarvis F, Sloop KW, Wu H. The GLP-1 receptor is expressed in pancreatic α-cells and suppresses glucagon secretion. Diabetes In Revision.

111. Allard C, Xu B, Salven, Levin ER, Mauvais-Jarvis F*. Loss of nuclear estrogen receptor-α

differentially impairs insulin secretion and insulin sensitivity in male and female mice. Diabetes In Revision.

112. Mauvais-Jarvis F*. Sex differences in the pharmacological response to drugs. Pharmacol

Rev. Invited review in preparation. 113. Tate C, Tiano J, Bin Y, DiMarchi R, Mauvais-Jarvis F*. Targeted estradiol delivery to

pancreatic islets using an inactive glucagon-like peptide-1 vector protects functional β-cell mass in male pre-clinical models of type 1 diabetes. In preparation.

114. Zimmerman MA, Hutson D, Mauvais-Jarvis F, Lindsey SH. Effect of the combination

bazedoxifene with estradiol on mesenteric arteries relaxation in male and female mice In preparation.

115. Marlatt, K, Ravussin, E, Mauvais-Jarvis F*. Effect of conjugated estrogens/bazedoxifene

on insulin sensitivity and energy metabolism in obese postmenopausal women: A randomized, double-blind, crossover, pilot trial. In preparation.

b. Abstracts (from studies not yet published only) 116. Tiano J, Finan B, DiMarchi R, Mauvais-Jarvis F*. A Glucagon like peptide-1-estrogen

fusion peptide shows enhanced efficacy in preventing insulin-deficient diabetes in mice. (OR)The Endocrine Society's 94nd Annual Meeting. Houston, TX. June 22-24, 2012.

117. Xu B, Allard C, Mauvais-Jarvis F*. Estrogen complexes improve the unfolded protein

response and prevent ER-stress induced β cell failure in Akita mice. Diabetes. June 2015 64:A35 (131OR).

118. Allard C, Xu B, Korach KS, Levin ER, Mauvais-Jarvis F*. Estrogens Stimulates Hepatic

Fibroblast Growth Factor-21 Production in Mice. Diabetes 2016 Jun; 65 (Supplement 1): A458-A523.

May 10, 2018 119. Marlatt, K, Ravussin, E, Mauvais-Jarvis F*. Effect of Conjugated Estrogens/Bazedoxifene

on Insulin Sensitivity and Energy Metabolism in Obese Postmenopausal Women: A Randomized, Double-Blind, Crossover, Pilot Trial. Diabetes 2017 Jun; 1259-P

c. book chapters and didactic publications

120. Mauvais-Jarvis F. Type 2 diabetes. Impact Médecin. 1992. French

121. Mauvais-Jarvis F. Type 1 diabetes. Impact Médecin. 1992. French

122. Mauvais-Jarvis F. Diabetes in the elderly. Impact Médecin. 1992. French 123. Mauvais-Jarvis F. Diabetes and pregnancy. Impact Médecin. 1992. French 124. Mauvais-Jarvis F. Diabetic ketoacidosis. Impact Médecin. 1992. French 125. Mauvais-Jarvis F. Hyperosmolarity. Impact Médecin. 1992. French 126. Mauvais-Jarvis F. Hyperthyroidism. Impact Médecin. 1993. French 127. Mauvais-Jarvis F. Grave’s disease. Impact Médecin. 1993. French 128. Mauvais-Jarvis F. Grave’s ophtalmopathy. Impact Médecin. 1993. French 129. Mauvais-Jarvis F. Hypothyroidism. Impact Médecin. 1993. French 130. Mauvais-Jarvis F. Thyroid nodules. Impact Médecin. 1993. French 131. Mauvais-Jarvis F. Hyperprolactinemia. Impact Médecin. 1993. French 132. Mauvais-Jarvis F. Prolactin pitituitary adenoma. Impact Médecin. 1993. French 133. Mauvais-Jarvis F. Hypercortisolism. Impact Médecin. 1994. French 134. Mauvais-Jarvis F. Cushing’s disease. Impact Médecin. 1994. French 135. Mauvais-Jarvis F. Adrenal insufficiency. Impact Médecin. 1994. French 136. Mauvais-Jarvis F. Endocrine tumors of the pancreas. Impact Médecin. 1994. French 137. Mauvais-Jarvis F. Hirsutism. Impact Médecin. 1994. French 138. Mauvais-Jarvis F. Amenorrhea. Impact Médecin. 1994. French 139. Mauvais-Jarvis F. Anorexia nervosa. Impact Médecin. 1994. French

140. Lubetzki J, Chanson P, Mauvais-Jarvis F, DelaTour MC, Chedin P, Duranteau L, Assayag

M, Caher-Varsaux J. Clinical Cases in Endocrinology and Metabolism. Flammarion Medecine-Science. 1997. 240 pp. French

141. Mauvais-Jarvis F. Clinical symptoms of diabetes mellitus. April 2000. Alfediam/Uni-Médecine. Electronic journal. .(www.uni-medecine.com). French

May 10, 2018

142. Guillausseau PJ., Virally M. L., Mauvais-Jarvis F., Martinez M., Kevorkian J.P., Warnet A. : Diabète de type 2 : Update on diagnosis, classification and pathogenesis. Sang Thrombose Vaisseaux. 2000. 10 (12) :658-63. French

143. Virally M.L., Kevorkian J.P., Martinez M., Mauvais-Jarvis F., Guillausseau P.J., Warnet

A. : Post-prandial hyperglycemia: An essential parameter in the vascular complications of type 2 diabetes. Sang Thrombose Vaisseaux.10 (12) :667-72. French

144. Mauvais-Jarvis F, Andreelli F.: Therapeutic perspectives for type 2 diabetes. 13e

Symposium on Diabetes Mellitus. 2001 Elsevier. p318-328. French. 145. Andreelli F, Mauvais-Jarvis F: Pathophysiology of glucose transport. 13e Symposium on

Diabetes Mellitus. 2001 Elsevier. p86-104. French 146. Mauvais-Jarvis F, Andreelli F: Interaction between insulin resistance and b-cell

dysfunction in the developpement of type 2 diabetes. 13e Symposium on Diabetes Mellitus. 2001 Elsevier. p118-128. French

147. Mauvais-Jarvis F, Postic C. : Pathogenesis of Type 2 diabetes mellitus : Insights from

knockout mice. 13e Symposium on Diabetes Mellitus. 2001 Elsevier. p106-117. French 148. Mauvais-Jarvis F., Postic C., Girard J. Use of transgenic mice in the analysis of the

mechanisms of insulin resistance and type 2 diabetes in humans. Médecine Thérapeutique Endocrinologie. 2001.

149. Mauvais-Jarvis F. Pathogenesis of Type 2 diabetes: Insights from genetic mouse models.

In Textbook of Diabetes Mellitus. A. Grimaldi Flammarion Medecine-Science. 2005. French

150. Alvarez-Mercado AI, Navarro G, Mauvais-Jarvis F. Reproductive hormones and islet adaptation to metabolic stress. The Islets of Langerhans. 2nd ed. Edited by Md Shahidul. Islam. Springer. 2014

151. Mauvais-Jarvis F. Introduction. “Sex and gender factors affecting metabolic homeostasis,

diabetes and obesity”. Edited by Franck Mauvais-Jarvis. Springer. 2018. 152. Mauvais-Jarvis F. Epidemiology of sex differences in diabetes and obesity. In “Sex and

gender factors affecting metabolic homeostasis, diabetes and obesity”. Edited by Franck Mauvais-Jarvis. Springer. 2018.

153. Mauvais-Jarvis F. Menopause, estrogen and glucose homeostasis in women. In “Sex and

gender factors affecting metabolic homeostasis, diabetes and obesity”. Edited by Franck Mauvais-Jarvis. Springer. 2018.

154. Mauvais-Jarvis F, LeMay C, Tiano JP, Liu S, Kilic G, Xu B, Tate C, Allard C. The role of

estrogen receptors in β-cell physiopathology. In “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity”. Edited by Franck Mauvais-Jarvis. Springer. 2018.

d. Books edited

1. Sex and gender factors affecting metabolic homeostasis, diabetes and obesity. Edited by Franck Mauvais-Jarvis. Springer. 2018.

May 10, 2018

e. Patents

1. 2001: Modulator of p85PI 3-kinase in the treatment of insulin resistance. Inventors: Kahn C.R., Mauvais-Jarvis F, Ueki K., Cantley L.C., Fruman D.A.

PRESENTATIONS INVITED PRESENTATIONS 1999 - Genetic models of insulin resistance. Lausanne Institute of

Pharmacology, Switzerland. 2000 - Genetic Models of type 2 Diabetes. Institut Pasteur of Lille, France.

- Transgenic models of type 2 diabetes. Saint-Louis Hospital, Paris, France. - Pathogenesis of type 2 Diabetes: What can we learn from KO mice? Hotel Dieu Hospital Paris, France. - Interaction between insulin resistance and beta-cell dysfunction in type 2 diabetes. Symposia on Diabetes Mellitus, La Baule, France. - Therapeutic perspectives for type 2 diabetes. Symposia on Diabetes Mellitus, La Baule, France. - Transgenic models of insulin resistance. 16th Scientific Meeting of Pediatric Endocrinology. Paris, France. - Insights into insulin resistance from knockout mouse models. Diabetes Center, University of California San Francisco.

2001 – Symposia. Clinical and genetic insights on idiopathic type 1 Diabetes in Afro- Carribeans. Novo-Nordisk Pharmaceuticals. La Defence, France - Clinical insights on insulin resistance from KO mice. Hotel Dieu Hospital, Nantes France. - Symposia. Clinical implications of insulin resistance. French Society of Biology. Nantes, France - Insulin resistance: molecular mechanisms & potential new drug targets Dept of Clinical Research, Endocrine & Metabolism. Merck. Rahway, NJ. - Insulin resistance: molecular mechanisms & potential new drug targets. Dept of Clinical Pharmacology. Merck. Rahway, NJ. - Clinical Characterization of Phasic Insulin Dependent Diabetes. Diabetes Center, University of California, San Francisco. - Insights into the pathogenesis of type 2 diabetes from humans and knockout model. Department of Medicine. Baylor College of Medicine

2003 - Endocrinology Grand Round. Division of Diabetes, Endocrinology & Metabolism, Baylor College of Medicine. “Ketosis-prone diabetes in African- Americans: Clinical and genetic Characterization”. Department of Medicine, Baylor College of Medicine, Houston, TX

2004 - Endocrinology Grand Round. Ketosis-prone diabetes in African-Americans: Clinical and genetic Characterization. Department of Medicine. Emory University, Atlanta, GA. - Endocrinology Grand Round. Ketosis-prone diabetes in African-Americans: Clinical and Genetic Characterization. Department of Medicine, UT Southwestern Medical Center, Dallas, TX .

2005 - Seminar. Department of Pediatrics, Division of Endocrinology, Texas Children Hospital. Sex steroids and diabetes: From patients to genetic mouse models.

May 10, 2018 - Seminar. Dept Molecular & Cellular Biology. Baylor College of Medicine Estrogen receptor-alpha and diabetes prevention. - Medicine Grand Round. Baylor College of Medicine. “Estrogen and diabetes. Cellular mechanism and clinical implications. - Seminar. Huffington Center on Aging, Baylor College of Medicine. “Sex steroid receptors and pancreatic beta-cells: Role in survival, insulin production and diabetes”.

2006 – Seminar. Estrogen receptors and pancreatic beta-cells. Role in survival and implications for diabetes. Pacific Northwest Research Institute, University of Washington, Seattle, WA . - Seminar. Emerging role of sex steroid receptors in diabetes. Insights from genetic mouse models. Penn Diabetes Center and University of Pennsylvania, Philadelphia, PA. - Seminar. Emerging role of sex steroid receptors in beta-cell survival. Implications for diabetes. Division of Diabetes, Metabolism and Molecular Medicine, Northwestern University, Chicago. - Seminar. Emerging role of sex steroid receptors in diabetes. Insight from genetic mouse models. Division of Endocrinology, Metabolism and Bone, Mount Sinai School of Medicine, New York. - Seminar. Emerging role of sex steroid receptors in pancreatic beta-cell survival. Implications for diabetes. Larry Hilbom Islet Center and University of California Los Angeles, Los Angeles. - Seminar. Emerging role of sex steroid receptors in diabetes. Insight from genetic mouse models. Division of Metabolism, Endocrinology and Diabetes, University of Michigan.

2007 - Symposia. Role of estrogens in beta-cell survival. 7th Annual Rachmiel Levine Diabetes and Obesity Symposium. Advance in Diabetes Research. From Cell Biology to Cell Therapy. Long Beach, CA. - Endocrinology Seminar. Ketosis-prone diabetes. Clinical and genetic characterization. Division of Endocrinology, Feinberg School of Medicine, Northwestern University, Chicago, IL - Research Seminar. Sex steroids and diabetes: Cellular Mechanisms and Clinical Implication. Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL - Symposia. Endocrine Society. 89th Annual Meeting, Toronto, Canada. Role of sex steroids in beta-cell survival. - Symposia. EASD Islet Study Group. Brussel, Belgium. Sex hormones and beta-cell survival and function

2009 - Endocrinology Grand Round. Division of Diabetes, Endocrinology & Metabolism, Baylor College of Medicine. “Neonatal Programming of energy Metabolism by sex hormones”. Department of Medicine, Baylor College of Medicine, Houston, TX. - Pennington Biomedical Research Center, Baton Rouge, LA “Neonatal Programming of energy Metabolism by sex hormones”.

- Symposia. NIEHS clinical research unit opening. Estrogen receptors and pancreatic islet survival in diabetes: An example of bidirectional translational research.

- Seminar. Laboratory of Reproductive & Developmental Toxicology. NIEHS. “Emerging role of estrogens and androgens in the regulation and programming of energy homeostasis”. - Seminar. Division of Diabetes. Department of Medicine University of Texas Health Science Center San Antonio, TX.

May 10, 2018 “Programming of energy homeostasis by sex hormones”.

2010 - Seminar. Northwestern University Comprehensive Center on Obesity, Feinberg School of Medicine, Chicago “Neonatal Programming of energy Metabolism by sex hormones”. - Symposia. American Diabetes Association. 70th Annual Meeting, Orlando, FL. Extranuclear estrogen receptors in beta-cells.

- Seminar. Department of Biochemistry, University of Wisconsin- Madison. “Neonatal Programming of energy Metabolism by sex hormones”.

- Seminar. Metabolic Diseases Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati.

- Seminar Center on Obesity Management and Prevention, Northwestern Children's Memorial Research Center, Chicago. “Neonatal Programming of energy Metabolism by sex hormones”. - Seminar Diabetes Center, University of California, San Francisco. Extranuclear estrogen receptors in beta-cells - Seminar Marcadia Biotech, Indianapolis. Importance of estrogen receptors as a target for Diabetes - Seminar Joslin Diabetes Center, Boston. Importance of extranuclear estrogen receptors in islet protection. - Seminar Division of Endocrinology, University of Utah. 1)The emerging syndrome of ketosis-prone diabetes. 2) Importance of extranuclear estrogen receptors in islet protection. 2011 - Seminar Division of Metabolism, Endocrinology & Diabetes, Department of Medicine, University of Michigan. Programming of energy homeostasis and adipose tissue by sex hormones - Symposia. Role of developmental exposure to estrogens and androgens in obesity, National Toxicology Program and NIEHS Workshop on environmental chemicals in the development of diabetes and obesity. Raleigh, NC Jan 11-13 - Seminar. Division of Endocrinology, Department of Medicine

University of Illinois Chicago. Importance of estrogen receptors in protecting islet mass.

- Seminar. Early life programming of energy homeostasis by sex hormones. Implications for obesity Department of Medicine, Naomie Berrie Diabetes Center, Columbia Universty. - Seminar. Importance of extranuclear estrogen receptors in protecting functional islet mass in diabetes. DERC, University of Pennsylvania.

- Seminar. Role of estrogen receptors in protecting pancreatic islets in diabetes. Department of Physiology, University of Mississipi Medical

Center, Jackson, MS. - Symposia. Sex steroids and metabolic programming. French

Diabetes Society (SFD) Annual Meeting. Geneva, Switzerland. - Seminar. Importance of estrogen receptor in protecting functional b-

cell mass. Division of Endocrinology, Metabolism and Bone, Mount Sinai School of Medicine, New York.

- Seminar.Role of estrogen receptors in diabetes protection. Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas TX

- Seminar . Importance of estrogen receptor in protecting functional beta-cell mass. Clinical Research Institute of Montreal, Montreal, CA

- Seminar . Importance of estrogen receptor in protecting functional beta-cell

May 10, 2018 mass. Division of Endocrinology. Tulane University Medical Center, New Orleans, LA.

- Seminar.Importance of estrogen receptor in protecting functional beta-cell mass. Division of Endocrinology. Vanderbilt Diabetes Research Center, Nashville, TN

2012 - Seminar. Department of Biophysics, University of Illinois Chicago. Importance of estrogen receptors in protecting islet mass. - Seminar. Department of Medicine, University of Pittsburgh. Importance of estrogen receptors in protecting beta-cell mass. - Seminar. Department of Pediatric, Indiana University. Importance of estrogen receptors in protecting beta-cell mass. - Symposia. Estrogen protection of human beta-cells. Implication for the use of SERMs and TSEC in diabetes. Pfizer. Estrogen , SERMs and TSEC meeting. Tampa, FL - Seminar. Importance of estrogen receptors in diabetes protection. Department of Medicine. Medical College of Wisconsin - Symposia. Importance of estrogen receptors in protecting beta-cell mass. Islet Biology Meeting. Stockholm, Sweden - Seminar. Estrogen receptors and beta-cell Annual Summer School on Molecular Metabolism, Avernæs, Denmark 2013 - Seminar. Targeted estrogen action to prevent diabetes. Department of Medicine . University of Wisconsin Madison - Seminar. Targeted estrogen action to prevent diabetes. Northwestern University Feinberg Cardiovascular Institute. Chicago

- Seminar. Targeted estrogen delivery for diabetes prevention. University of Texas Health Science Center at Houston - Meites Annual Lecture. Targeted estrogen delivery to prevent beta-cell failure. Department of Physiology. Michigan State University. - Symposia. Keynote speaker. Targeted estrogen delivery to prevent beta-cell failure. Translational Medicine Symposium. University of North Carolina Chapel Hill

- Symposia. Use of estrogen and TSEC in diabetes. Pfizer. Estrogen , SERMs and TSEC scientific meeting. Tampa, FL

- Symposia. Joslin and Harvard International Symposium on Diabetes/Boston, MA. Novel role of the AR in beta-cell function

- Seminar. Dept Pharmacology. Tulane HSC-New Orleans - Seminar. Dept Biochemistry. Tulane HSC-New Orleans - Seminar. Neurosciences Program. Tulane University-New Orleans

2014 - Seminar. Pennington Biomedical Research Center. Baton Rouge, LA

- Seminar. Dept of Physiology and Biophysics. University of Louisville, KY - Seminar. Dept Physiology. Tulane HSC-New Orleans - Short talk. Keystone symposia on emerging concepts and targets in islet Biology, Keystone CO

- Symposia. Pfizer. Estrogen , SERMs and TSEC scientific meeting.Tampa, FL. - Seminar. Dept Pharmacology. LSU-New Orleans. - Seminar. Dept of Cellular & Structural Biology, Tulane University New Orleans - Symposia. Mexico Sanofi Diabetes Conference, Tulane University New Orleans - Seminar. Xiamen Diabetes Institute, Xiamen University, Xiamen, China

May 10, 2018 2015 - Seminar. Dept Medicine. Washington University St Louis.

- Plenary Lecture. French Diabetes Society (SFD) Annual Meeting. Bordeaux, France. - Symposia. Organization for the Study of Sex Differences Annual Meeting. Stanford CA - Seminar. Dept Biochemistry. LSU Health Sciences Center New Orleans - Symposia on Gender Differences in the Pathophysiology of Diabetes. American Diabetes Association, Boston, MA. - Seminar. BIRCWH Scholars. Tulane Health Sciences Center New Orleans

- Symposia. Mexico Sanofi Diabetes Conference, Tulane HSC New Orleans

- Grand Rounds. Dept of Medicine Tulane Health Sciences Center. - Seminar. Tulane National Primate Research Center - Seminar. Aging Center. Tulane Health Sciences Center New Orleans - Seminar. Dept of Pathology and Laboratory Medicine. Tulane Health Sciences Center New Orleans - Symposia. Diabetes and Menopause. North American Menopausal Society Annual Meeting. Las Vegas, NV - Seminar. Dept Physiology. LSU-New Orleans - Symposia. Cardiovascular, Renal and Metabolic Diseases: Physiology and Gender. American Physiological Society Annual Meeting. Annapolis ML.

- Seminar. Neuroscience Program. Tulane University. New Orleans

2016 - Seminar. Dept Physiology. LSU-New Orleans

- Seminar. Hayward Genetic Center. Tulane Health Sciences Center New Orleans - Symposia 16th Annual Rachmiel Levine-Arthur Diabetes Research Symposium, Long Beach, CA - Seminar. Diabetes, Obesity & Metabolism Institute. Mount Sinai School of Medicine, NYC - Seminar. Diabetes Research Center, Albert Einstein School of Medicine, NYC - Symposia. Estrogen, SERMs and TSEC, Pfizer scientific advisory board meeting. Clearwater, - Seminar. University of New Mexico Health Sciences Center, Albuquerque.

- Seminar. National Institutes of Environmental and Health Sciences. NC - Symposia. Korean Society of Food Science and Nutrition Annual meeting. Jeju Island, Korea - Symposia. Nutrition and Physical Activity Annual Meeting. Seoul National University, Korea. - Seminar. University of Iowa College of Medicine, Iowa City. - Plenary Lecture, Diabetes Research Center, University of Alabama Birmingham

2017 – Seminar Saban Research Institute, Children's Hospital Los Angeles, University of Southern California - Symposia. Keystone Symposia on Sex and Gender Factor Affecting Metabolic Homeostasis Diabetes and Obesity, Lake Tahoe, CA - Symposia. Endocrine Society, ENDO 2017, in Orlando, Florida - Symposia. Sex differences: From neuroscience to the clinic. American University

- Symposia. Experimental Biology, Chicago. - Symposia 2017 FASEB Summer Research Conference: “Rapid Signaling & Genomic Hormone Action in Health & Disease”. - Symposia. Sex and the Kidneys: Sex Differences in Renal Disease Conference. NIH,

May 10, 2018 Bethesda - Symposia. Islet biology/Regeneration Symposia. Mayo Clinic, Rochester.

- Seminar. Department of Structural and Cellular Biology. Tulane Health Sciences Center New Orleans

2018 - Symposia on Sex differences in cardiovascular disease in women. University

of Kentucky Lexington - Seminar, Harvard Reproductive Sciences Center, Massachusetts General Hospital,

Boston. - Seminar, University of Massachusetts School of Medicine, Worcester, MA - Symposia. 2nd National Conference Sex Differences and Metabolism Across the

Life-Span. University of Colorado. - Symposia. APS conference on "Cardiovascular, Renal and Metabolic Disease:

Gender-Specific Implications for Physiology