Cuthbert SRF Forum May 2014
-
Upload
wef -
Category
Health & Medicine
-
view
862 -
download
0
description
Transcript of Cuthbert SRF Forum May 2014
![Page 1: Cuthbert SRF Forum May 2014](https://reader034.fdocuments.in/reader034/viewer/2022051609/547b5db7b47959a4098b4e06/html5/thumbnails/1.jpg)
Schizophrenia Research ForumWebinarMay 28, 2014
Bruce N. Cuthbert, Ph.D.
Director, Division of Adult Translational Research
National Institute of Mental Health
Toward Precision Medicine for Mental Disorders:NIMH Research Domain Criteria (RDoC)
![Page 2: Cuthbert SRF Forum May 2014](https://reader034.fdocuments.in/reader034/viewer/2022051609/547b5db7b47959a4098b4e06/html5/thumbnails/2.jpg)
Disclosures
• Dr. Cuthbert is a Title 42 federal employee who is required to disclose all financial holdings as public record, and has no outside activities to disclose.
2
![Page 3: Cuthbert SRF Forum May 2014](https://reader034.fdocuments.in/reader034/viewer/2022051609/547b5db7b47959a4098b4e06/html5/thumbnails/3.jpg)
3
Schizophrenia: A complex syndrome
• Highly heterogeneous
• Michael Owen: “There is no such thing as schizophrenia.”
• Psychosis, hallucinations in other disorders
• Research task: Study the individual differences to find more precise diagnosis and intervention
![Page 4: Cuthbert SRF Forum May 2014](https://reader034.fdocuments.in/reader034/viewer/2022051609/547b5db7b47959a4098b4e06/html5/thumbnails/4.jpg)
Polygenic Risks for Mental Disorders
Cross-Disorder group of the PGC,Lancet, 2013
![Page 5: Cuthbert SRF Forum May 2014](https://reader034.fdocuments.in/reader034/viewer/2022051609/547b5db7b47959a4098b4e06/html5/thumbnails/5.jpg)
Neurodevelopment and Plasticity
Neurodevelopment
Environment
Age
![Page 6: Cuthbert SRF Forum May 2014](https://reader034.fdocuments.in/reader034/viewer/2022051609/547b5db7b47959a4098b4e06/html5/thumbnails/6.jpg)
6
NIMH Strategic Plan: Goal 1.4
• “Develop, for research purposes, new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures.”
![Page 7: Cuthbert SRF Forum May 2014](https://reader034.fdocuments.in/reader034/viewer/2022051609/547b5db7b47959a4098b4e06/html5/thumbnails/7.jpg)
[Symptoms]• Elevated Stress
• Heightened threat reactivity
• Abnormalities in reward-related activity• Substance abuse
• Hippocampus: encoding functions• Perceptual aberrations
• Social withdrawal• Need for social relationships
• Disruptions in network connectivity• Dysfunctions in arousal/activation systems
![Page 8: Cuthbert SRF Forum May 2014](https://reader034.fdocuments.in/reader034/viewer/2022051609/547b5db7b47959a4098b4e06/html5/thumbnails/8.jpg)
8
RDoC: Quick Summary
• A framework to study mechanisms that cut across traditional disorder boundaries
• Dimensional approach – understand transitions from normal to mild, moderate, severe dysfunction
• Will inform, not compete with, future versions of DSM and ICD
• Toward personalized medicine in psychiatry, consistent with other areas of medicine
• http://www.nimh.nih.gov/research-priorities/rdoc/index.shtml