Curriculum Vitae Wasim Ahmad

Personal

Address Professor HEC-Distinguished National Professor Department of BiochemistryFaculty of Biological SciencesQuaid-i-Azam UniversityIslamabad, Pakistan E.mail: wahmad@mail.qau.edu.pk

Ahmad115@hotmail.com

Citizenship Pakistan

Education

PhD 1990 Department of BiochemistryUniversity of CambridgeEngland

M.Phil. 1984 Department of Biological SciencesQuaid-I-Azam UniversityIslamabad Pakistan

M.Sc. 1981 Department of Biological SciencesQuaid-I-Azam UniversityIslamabad Pakistan

Postdoctoral Research Experience

Department of DermatologyColumbia UniversityNew York, USA

Postdoctoral Research FellowTelethone Institute of Genetics and Medicine (TIGEM), via Olgettina 58, Milano 20132, Italy

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Postdoctoral Research FellowMRC-Molecular Medicine,Royal Postgraduate Medical School,Collier Building, Hammersmith Hospital, Ducane Road, London, England

Scholarships and Awards

2005 HEC-National Distinguished Professor

2002 Sitara-e-ImtiazGovt. of Pakistan

1999 Dermatology Foundation AwardDermik Laboratories Research GrantNew York, USA

1986-1990 Overseas Research Students (ORS) AwardChancellors of the UniversitiesBritish Government, England

Research Support

Ongoing Research Support

1. Identification of Non-syndromic Hearing Loss Genes (2004-2009)- Funded by National Institute of Health (NIH) Maryland-Bathesda USA (Amount Allocated----- 3,00,000 US $)

2. Identification of Genes Involved in Human Skin Disorders. Funded by Higher Education Commission (HEC) (Amount Allocated----- Rs. 6.900 Million)

Completed Research Support

1. Identification and Cloning of Inherited Alopecia, Ectodermal Dyspalsia and Nail Dyspalsia Genes (2002-2005) –Funded By Higher Education Commission (HEC) Islamabad, Pakistan (Amount Allocated Rs. 20.671 million-----3,44,828 US $)

2. Identification of Genes Involved in Hereditary Hearing Impairment (2003-2005) Funded By Higher Education Commission (HEC) Islamabad, Pakistan (Amount

Allocated Rs. 1.87 million----- 32,242 US $)

3. Identification of Loci/Genes in Pakistani Kindreds with Inherited Neurological Disorders (2001-2004) Funded by ISESCO-Rabat Morocco (Amount Allocated 6,500 US $)

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4. Identification of Loci/Genes in Five Pakistani Kindreds with Ectodermal Dysplasia(2000-2003) Funded by Pakistan Science Foundation (PSF)----- (Amount Allocated Rs. 8,24,000----- 14,207 US $)

5. Quaid-I-Azam University Research Fund September 2001-June 2002Identification of Loci/Genes in Pakistani Kindreds showing hereditary hearing impairment. (Amount Allocated Rs. 1,00,000)

6. Third World Academy of Sciences Italy July 2000 March 2001Identification of Loci/Genes in Five Pakistani Kindreds with Ectodermal Dysplasia(Amount Allocated 6,000 US $)

Collaborative Research Programs

Identification of Loci/Genes in Pakistani Kindreds showing hereditary hearing impairment(Collaborator-Dr. Suzanne M Leal, Associate Professor, Baylor College of MedicineDepartment of Molecular and Human Genetics, Houston, TX 77030 USA)

PhD Students Research Programs

PhD Produced: 18PhD students working in the lab: 10

M.Phil Students Research Programs

M. Phil Produced: 81M. Phil students working in the lab: 8

Teaching: Courses teaching at M.Sc., M.Phil and PhD levels

1. Nucleic Acids2. Protein Chemistry3. Molecular Biology of Gene Expression and Structure

Editor and Reviewer of International Journals

1. Associate Editor of BMC-Medical Genetics-London-UK

2. Reviewing papers published in the following international peer-reviewed journals

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a: American Journal of Human Genetics-USA

b: American Journal of Medical Genetics-USA

c: Human Genetics-Germany

d: Journal of Medical Genetics-UK

e: British Journal of Dermatology-UK

f: Molecular Vision-UK

g: Clinical and Experimental Dermatology-UK

h: European Journal of Dermatology-UK

i: BMC Medical Genetics-UK

j: Molecular Biology Reporter-Australia

k: Archives of Dermatological Research-Germany

l: Journal of Dermatological Science-Japan

m: Journal of the European Academy of Dermatology and Venereology-France

n: Pediatric Dermatology-USA

Publications

1. Kalsoom UE , Habib R, Khan B, Ali G, Ali N, Ansar M, Ahmad W (2010) Mutationsin lipase h gene underlie autosomal recessive hypotrichosis in five Pakistani families. Acta Derm Venereol 90:93-94.

2. Gul Naz, Ghazanfar Ali, Syed Kamran-ul-Hassan Naqvi, Zahid Azeem, Wasim Ahmad (2010) Mapping of a novel autosomal recessive hypotrichosis locus on chromosome 10q11.23-22.3. Human Genetics 127:395-401

3. Syed Kamran-ul-Hassan Naqvi, Zahid Azeem, Ghazanfar Ali, Wasim Ahmad (2010) A novel splice-acceptor site mutation in CDH3 gene in a consanguineous family exhibiting hypotrichosis with juvenile macular dystrophy (HJMD). Archives of Dermatological Research (In Press)

4. Margit Shraders, Kwanghyuk Lee, Jaap Ostrick, Patrick LM Huygen, Ghazanfar Ali, Lies H Hoeftslot, Sulman Basit, Muhammad Ansar, Wasim Ahmad, Ronald JC Admiraal, Suzanne M Leal, Hannie Kramer (2010) Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal recessive nonsyndromic hearing impairment. American Journal of Human Genetics 86: 138-147.

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5. Gul Naz, Bushra Khan, Ghazanfar Ali, Zahid Azeem, Abdul Wali, Muhammad Ansar, Wasim Ahmad (2009). Novel missense mutations in lipase H (LIPH) gene causing autosomal recessive hypotrichosis (LAH2). Journal of Dermatological Science 54:12-16

6. Muhammad Ayub, Sulman Basit, Musharraf Jelani, Fazal-ur-Rehman, Muhammad Iqbal, Masoom Yasinzai, Wasim Ahmad (2009) A Homozygous Nonsense Mutation in Human Desmocollin-3 (DSC3) Gene Underlies Hereditary Hypotrichosis and Recurrent Skin Vesicles. American Journal of Human Genetics 85: 515-520

7. Muhammad Tariq, Muhammad Nasim Khan, Wasim Ahmad (2009) Ectodermal dysplasia-cutaneous syndactyly syndrome maps to chromosome 7p21.1-p14.3. Human Genetics 125: 421-429

8. Muhammad Tariq, Muhammad Ayub, Musharraf Jelani, Sulman Basit, Gul Naz, Naveed Wasif, Syed Irfan Raza, Abdul Khaliq Naveed, Saad ullah Khan, Zahid Azeem, Masoom Yasinzai, Abdul Wali, Ghazanfar Ali, Muhammad Salman Chishti, Wasim Ahmad (2009). Mutations in P2RY5 gene underlie autosomal recessive hypotrichosis in thirteen Pakistani families. British Journal of Dermatology 160:1006-1010

9. M Tariq, Z Azeem, G Ali, M S Chishti, W Ahmad (2009). A mutation in HPGD gene encoding NAD+-dependent 15-hydroxyprostaglandin dehydrogenase underlies an isolated congenital nail clubbing (ICNC). Journal of Medical Genetics 46:14-20

10. Syed Kamran-ul-Hassan Naqvi, Syed Irfan Raza, Abdul Khaliq Naveed, Peter John, Wasim Ahmad (2009). A novel deletion mutation in phospholipase H (LIPH) gene in a consanguineous Pakistani family with autosomal recessive hypotrichosis (LAH2). British Journal of Dermatology 160:190-194

11. Muhammad Naeem, Sabeen Sheikh, Wasim Ahmad (2009) A mutation in CTSK gene in an autosomal recessive pycnodysostosis family of Pakistani origin. BMC Medical Genetics 10: 76-81

12. Zahid Azeem , Syed Kamran-Ul-Hassan Naqvi, Muhammad Ansar, Abdul Wali, Abdul Khaliq Naveed, Ghazanfar Ali, Muhammad Jawad Hassan, Muhammad Tariq, Sulman Basit, Wasim Ahmad (2009) Recurrent mutations in functionally-related EDA and EDAR genes underlie X-linked isolated hypodontia and autosomal recessive hypohidrotic ectodermal dysplasia. Archives of Dermatological Research 301: 625-629

13. Muhammad Salman Chishti, Merry-Lynn McDonald, Kwanghyuk Lee, Muhammad Jawad Hassan, Muhammad Ansar, Wasim Ahmad, Suzanne M Leal (2009). Novel autosomal recessive non-syndromic hearing impairment locus (DFNB71) maps to chromosome 8p22-21.3. Journal of Human Genetics 54:141-144

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14. Julie M. Schultz, Shaheen N. Khan, Zubair M. Ahmed, Saima Riazuddin,2 Barbara Ploplis, Madhulika Kabra, Kwanghyuk Lee, Muhammad J. Hassan, Ghazanfar Ali, Muhammad Ansar, Manju Ghosh, Edward R. Wilcox, Wasim Ahmad, Glenn Merlino, Suzanne M. Leal, Sheikh Riazuddin, Thomas B. Friedman, Robert J. Morell (2009) Mutations affecting regulation of the HGF gene are the cause of nonsyndromic hearing loss DFNB39. American Journal of Human Genetics 85: 25-39

15. Kamran Balighi, Vahideh Lajevardi, Fatemeh Moeineddin, Musharraf Jelani, Azita Nikoo, Banafshe Tamizifar, Qamar Javed, Wasim Ahmad, Nima Parvaneh (2009) A Novel Deletion Mutation in the Human Hairless (HR) Gene in an Iranian Family with Atrichia and Papular Lesion. Clinical and Experimental Dermatology 34: 498-500

16. Sulman Basit, Syed Kamran-ul-Hassan Naqvi, Naveed Wasif, Ghazanfar Ali, Muhammad Ansar, Wasim Ahmad (2008). A novel insertion mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene underlies Grebe-type chondrodysplasia in a consanguineous Pakistani family. BMC Medical Genetics 9: 102

17. Muhammad Tariq, Muhammad S. Chishti, Ghazanfar Ali, Wasim Ahmad (2008). A Novel Locus for Ectodermal Dysplasia of Hairs, Nails and Teeth Type Maps to Chromosome 18q22.1-22.3. Annals of Human Genetics 72: 19-25

18. Zahid Azeem, Musharraf Jelani, Gul Naz, Muhammad Tariq, Naveed Wasif, Syed Kamran-ul-Hassan Naqvi, Muhammad Ayub, Masoom Yasinzai, Muhammad Amin-ud-din, Abdul Wali, Ghazanfar Ali, Muhammad Salman Chishti, Wasim Ahmad (2008). Novel mutations in G protein-coupled receptor gene (P2RY5) in families with autosomal recessive hypotrichosis (LAH3). Human Genetics 123: 515-519

19. M Jelani, N Wasif, G Ali, MS Chishti, W Ahmad (2008) A novel deletion mutation in LIPH gene causes autosomal recessive hypotrichosis (LAH2). Clinical Genetics 74: 184-188.

20. M. Jelani, M. Salman Chishti, W. Ahmad (2008). A Novel Splice Site Mutation in CDH3 Gene in Hypotrichosis with Juvenile Macular Dystrophy. Clinical and Experimental Dermatology 34: 68-73

21. Muhammad Tariq, Saeed Ahmad, Wasim Ahmad (2008) A novel missense mutation in TRPS1 gene underlies trichorhinophalangeal syndrome type III. British Journal of Dermatology 159: 47-478

22. Rob W.J. Collin, Ersan Kalay, Muhammad Tariq, Theo Peters, Bert van der Zwaag, Hanka Venselaar, Jaap Oostrik, Kwanghyuk Lee, Zubair M. Ahmed, Refik Çaylan, Yun Li, Henk A. Spierenburg, Erol Eyupoglu, Angelien Heister, Saima Riazuddin, Elif Bahat, Muhammad Ansar, Selcuk Arslan, Bernd Wollnik, Han G. Brunner, Cor W.R.J. Cremers, Ahmet Karaguzel, Wasim Ahmad, Frans P.M. Cremers, Gert Vriend, Thomas B. Friedman, Sheikh Riazuddin, Suzanne M. Leal, and Hannie

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Kremer (2008) Mutations of ESRRB encoding estrogen-related receptor beta cause autosomal recessive nonsyndromic hearing impairment DFNB35. American Journal of Human Genetics 82: 125-138

23. M. Salman Chishti, N. Kausar, M. Arshad Rafiq, M. Amin, W. Ahmad (2008). A novel missense mutation in RSPO4 gene underlies autosomal recessive congenital anonychia in a consanguineous Pakistani family. British Journal of Dermatology 158: 621-623

24. Muhammad S. Chishti, Attya Bhatti, Sana Tamim, Kwanghyuk Lee, Merry-Lynn McDondald, Suzanne M. Leal, Wasim Ahmad (2008). Splice site mutations in TRIC gene underlies autosomal recessive nonsyndromic hearing impairment in Pakistani families. Journal of Human Genetics 53: 101-105

25. Attya Bhatti, Kwanghyuk Lee, Merry-Lynn McDonald, Muhammad Jawad Hassan, Ramana Gutala, Muhammad Ansar, Wasim Ahmad, Suzanne M Leal (2008). Mapping of a new autosomal recessive non-syndromic hearing impairment locus (DFNB45) to chromosome 1q43-q44. Clinical Genetics 73: 395-398

26. Muhammad Jawad Hassan, Muhammad Salman Chishti, Syed Muhammad Jamal, Muhammad Tariq, Wasim Ahmad (2008). A Syndromic form of Autosomal Recessive Congenital Microcephaly (Jawad Syndrome) Maps to Chromosome 18p11.22-q11.2. Human Genetics 123:77-82

27. Muhammad Jawad Hassan, Saqib Mahmood, Ghazanfar Ali, Nazia Bibi, Muhammad Arshad Rafiq, Muhammad Ansar, Wasim Ahmad (2008). Revealing Intragenic Deletions in Dystrophin Gene: Screening 18 Exons of the Gene in 211 Pakistani Patients with Duchenne Muscular Dystrophy. Pediatrics International 50: 162-166

28. Rashid M, Khalil S, Ayub N, Ahmad W, Khan AG (2008). Categorization of aspergillus flavus and aspergillus parasiticus isolates of stored wheat grains into aflatoxinogenics and non- aflatoxinogenics. Pakistan Journal of Botany 40:2177-2192

29. Malik S, Girisha KM, Wajid M, Roy AK, Phadke SR, Haque S, Ahmad W, Koch MC, Grzeschik KH (2007). Synpolydactyly and HOXD13 polyalanine repeat: addition of 2 alanine residues is without clinical consequences. BMC Medical Genetics 8: 78

30. Ghazanfar Ali, Muhammad Salman Chishti, Syed Irfan Raza, Peter John, Wasim Ahmad (2007). A mutation in the Lipase H (LIPH) gene underlie autosomal recessive hypotrichosis. Human Genetics 121: 319-325

31. A. Wali, G. Ali, P. John, K. Lee, M. S. Chishti, S. M. Leal, W. Ahmad (2007) Mapping of a Gene for Alopecia with Mental Retardation Syndrome (APMR3) on Chromosome 18q11.2-q12.2. Annals of Human Genetics 71: 1-8.

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32. Abdul Wali, Muhammad Salman Chishti, Muhammad Ayub, Masoom Yasinzai, Kafaitullah, Ghazanfar Ali, Peter John, Wasim Ahmad (2007). Localization of a novel autosomal recessive hypotrichosis locus (LAH3) to chromosome 13q14.11-q21.32. Clinical Genetics: 72: 23-29.

33. M. Naeem, P. John, G. Ali, W. Ahmad (2007).Pure hair-nail ectodermal dysplasia maps to chromosome 12p11.1-q21.1 in a Pakistani consanguineous family. Clinical & Experimental Dermatology 32:502-505.

34. Muhammad Tariq, Naveed Wasif, Wasim Ahmad (2007). A novel deletion mutation in EDAR gene in a Pakistani family with autosomal recessive hypohidrotic ectodermal dysplasia. British Journal of Dermatology 157: 207-209.

35. Muhammad Jawad Hassan, Maryam Khurshid, Zahid Azeem, Peter John, Ghazanfar Ali, Muhammad Salman Chishti, Wasim Ahmad (2007). Previously Described Sequence Variant in CDK5RAP2 Gene in a Pakistani Family with Autosomal Recessive Primary Microcephaly. BMC Medical Genetics 8: 58

36. Muhammad TARIQ, Naveed WASIF, Muhammad AYUB, Wasim AHMAD (2007). A novel 4-bp insertion mutation in EDA1 gene in a Pakistani family with X-linked hypohydrotic ectodermal dysplasia. European Journal of Dermatology 17: 209-212.

37. Asma Gul, Muhammad Tariq, Muhammad Nasim Khan, Muhammad Jawad Hassan, Ghazanfar Ali, Wasim Ahmad (2007). Novel protein truncating mutations in the ASPM gene in families with autosomal recessive primary microcephaly. Journal of Neurogenetics 21: 153-163.

38. Muhammad S. Chishti, Dost Muhammad, Mahmud Haider, Wasim Ahmad (2006). A novel missense mutation in MSX1 underlies autosomal recessive oligodontia with associated dental anomalies in Pakistani families. Journal of Human Genetics 51:872-878

39. M Naeem, M Wajid, K Lee, S M Leal, W Ahmad (2006). A Mutation in the Hair Matrix and Cuticle Keratin KRTHB5 Gene Causes Ectodermal Dysplasia of Hair and Nail Type. Journal of Medical Genetics 43: 274-279

40. Gul A, Hassan MJ, Mahmood S, Chen W, Rahmani S, Naseer MI, Dellefave L, Muhammad N, Rafiq MA, Ansar M, Chishti MS, Ali G, Siddique T, Ahmad W (2006). Genetic studies of autosomal recessive primary microcephaly in 33 Pakistani families: novel sequence variants in ASPM gene. Neurogenetics 7:105-110

41. Peter John, Ghazanfar Ali, Muhammad S. Chishti, Suzanne M. Leal, Wasim Ahmad (2006). Localization of a Novel Locus for Alopecia with Mental Retardation Syndrome to Chromosome 3q26.33-q27.3. Human Genetics 118:665-667

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42. Abdul Wali, Peter John, Asma Gul, Kwanghyuk Lee, Muhammad Salman Chishti, Ghazanfar Ali, Muhammad Jawad Hassan, Suzanne M. Leal, Wasim Ahmad (2006). A Novel Locus for Alopecia with Mental Retardation Syndrome (APMR2) Maps to Chromosome 3q26.2-q26.31. Clinical Genetics 70: 233-239

43. Muhammad Naeem, Musharraf Jelani, Kwanghyuk Lee, Ghazanfar Ali, Muhammad S. Chishti, Asma Gul, Peter John, Muhammad Jawad Hassan, Suzanne M Leal and Wasim Ahmad (2006) Ectodermal Dysplasia of Hair and Nail Type: Mapping of a Novel Locus to Chromosome 17p12-q21.2 and Mutation Analysis of Candidate Genes. British Journal of Dermatology 155: 1184-1190

44. Peter John, Muhammad Tariq, Muhammad Arshad Rafiq, Muhammad Amin-ud-din, Dost Muhammad, Ishrat Waheed, Muhammad Ansar, Wasim Ahmad (2006) Recurrent Intragenic Deletion Mutation in Desmoglein 4 Gene Underlies Autosomal Recessive Hypotrichosis in Two Pakistani Families of Balochi and Sindhi Origins. Archives of Dermatological Research 298:135-137

45. A. Wali, M. Ansar, M. N. Khan, W. Ahmad (2006). Atrichia with papular lesions resulting from a novel insertion mutation in the human hairless gene. Clinical and Experimental Dermatology 31: 1-4

46. Asma Gul, Muhammad Jawad Hassan, Sabir Hussain, Syed Irfan Raza, Muhammad Salman Chishti, Wasim Ahmad (2006). A Novel Deletion Mutation in CENPJ Gene in a Pakistani Family with Autosomal Recessive Primary Microcephaly. Journal of Human Genetics 51: 760-764

47. Regie Lyn P. Santos, Muhammad Jawad Hassan, Shaheen Sikandar, Ghazanfar Ali, Wasim Ahmad , Suzanne M Leal (2006). A Novel Locus for Autosomal Recessive Non-Syndromic Deafness (DFNB68) Maps to Chromosome 19p13.12-p13.2. Linkage Studies in two Consanguineous Families from Pakistan. Human Genetics 120: 85-92

48. Ali G, Santos RL, John P, Wambangco MA, Lee K, Ahmad W, Leal S (2006). The mapping of DFNB62, a new locus for autosomal recessive non-syndromic hearing impairment, to chromosome 12p13.2-p11.23. Clinical Genetics 69: 429-33

49. Hassan MJ, Santos RL, Rafiq MA, Chahrour MH, Pham TL, Wajid M, Hijab N, Wambangco M, Lee K, Ansar M, Yan K, Ahmad W, Leal SM (2006). A novel autosomal recessive non-syndromic hearing impairment locus (DFNB47) maps to chromosome 2p25.1-p24.3. Human Genetics 118: 605-610

50. Aamira Tariq, Mohammad Nasim Khan, Muhammad Jawad Hassan, Wasim Ahmad, Suzanne M Leal (2006). Localization of a novel autosomal recessive non-syndromic hearing impairment locus DFNB65 to chromosome 20q13.2-q13.32. Journal of Molecular Medicine 85: 432-440

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51. S Malik, AA Abbasi, M Ansar, W Ahmad, MC Koch, K-H Grzeschik (2006). Genetic heterogeneity of synpolydactyly: a novel locus SPD3 maps to chromosome 14q11.2-q12. Clinical Genetics 69: 518-524

52. Regie Lyn P. Santos, Hatem El-Shanti, Shaheen Sikandar, Kwanghyuk Lee, Attya Bhatti, Kai Yan, Maria H. Chahrour, Nathan McArthur, Thanh L. Pham, Amjad Abdullah Mahasneh, Wasim Ahmad, Suzanne M. Leal (2006). Novel Sequence Variants in the TMIE Gene in Families with Autosomal Recessive Non-syndromic Hearing Impairment. Journal of Molecular Medicine 84: 226-231

53. M. Naeem, D. Muhammad, W. Ahmad (2005): Novel mutations in the EDAR gene in two Pakistani consanguineous families with autosomal recessive hypohidrotic ectodermal dysplasia. British Journal of Dermatology 153: 46-50

54. Muhammad Arshad Rafiq, Mohammad Faiyaz-ul-Haque, Mohammad Amin ud Din, Sajid Malik, Muhammad Sohail, Muhammad Anwar, Sayedul Haque, Andrew D Paterson, Lap-Chee Tsui, Wasim Ahmad (2005): A novel locus of Ectodermal Dysplasia maps to Chromosome 10q24.32-q25.1. Journal of Investigative Dermatology 124: 338-342

55. John P, Aslam M, Rafiq MA, Amin-ud-din M, Ahmad W (2005): Atrichia with papular lesions in two Pakistani consanguineous families resulting from mutations in the hairless gene Archives of Dermatological Research 297: 226-230

56. Malik S, Ahmad W, Grzeschik KH, Koch MC (2005). A simple method for characterizing syndactyly in clinical practice. Genetic Counseling 16(3):229-38

57. Sajid Malik, Jörg Schott, Syed Wajahat Ali, Frank Oeffner, Muhammad Amin-ud-Din, Wasim Ahmad, Karl-Heinz Grzeschik and Manuela C Koch (2005). Evidence for clinical and genetic heterogeneity of syndactyly type I: the phenotype of second and third toe syndactyly maps to chromosome 3p21.31. European Journal of Human Genetics 13: 1268-1274

58. Regie Lyn P. Santos, Muhammad Wajid, Thanh L. Pham, Jawad Hussan, Ghazanfar Ali, Wasim Ahmad, Suzanne M. Leal (2005): Low prevalence of Connexin 26 (GJB2) mutations in Pakistani families with autosomal recessive non-syndromic hearing impairment. Clinical Genetics 67: 61-68

59. Malik S, Percin FE, Ahmad W, Percin S, Akarsu NA, Koch MC, Grzeschik KH (2005): Autosomal recessive mesoaxial synostotic syndactyly with phalangeal reduction maps to chromosome 17p13.3. American Journal of Medical Genetics 134: 404-408

60. Regie Lyn P. Santos, Muhammad Wajid, Mohammad Nasim Khan, Nathan McArthur, Thanh L. Pham, Attya Bhatti, Kwanghyuk Lee, Saba Irshad, Asif Mir, Kai Yan, Maria H. Chahrour, Muhammad Ansar, Wasim Ahmad and Suzanne M.

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Leal. (2005): Novel Sequence Variants in the TMC1 Gene in Pakistani Families with Autosomal Recessive Hearing Impairment. Human Mutation 26:396

61. Irshad S, Muhammad D, Santos RLP, Lee K, Haque S, Ahmad W, Leal SM (2005): Localization of a novel autosomal recessive non-syndromic hearing impairment locus DFNB55 to chromosome 4q12-q13.2. Clinical Genetics 68: 262-267

62. Muhammad Aslam, Muhammad Wajid, Maria H Chahrour, MS, Muhammad Ansar, Sayedul Haque, Thanh L Pham, Kai Yan, Wasim Ahmad, Suzanne M Leal (2005): A Novel Autosomal Recessive Non-Syndromic Hearing Impairment Locus (DFNB42) Maps to Chromosome 3q13.31-q22.3. American Journal of Medical Genetics 133: 18-22

63. Muhammad Faiyaz-Ul-Haque, Syed Hassan E. Zaidi, Lily M. King, Sayedul Haque, Megha Patel, Teepu Siddique, Wasim Ahmad, Lap-Chee Tsui and Daniel H. Cohn. (2005). Fine Mapping of the Split-hand/Split-foot Malformation (SHFM2) Locus to a 5.1 Mb Region on Xq26.3 and Exclusion of Candidate Genes. Clinical Genetics 67 : 93-97.

64. Asif Mir, Muhammad Ansar, Thanh L. Pham, Muhammad Wajid, Sayedul Haque, K Yan, Wasim Ahmad, Suzanne M. Leal (2005): Mapping of a new autosomal recessive non-syndromic hearing loss locus (DFNB46) to chromosome 18p11.32-p11.31. American Journal of Medical Genetics 133: 23-26

65. Muhammad Aslam, Asma Razzaq, Sayedul Haque, Kai Yan, Suzanne M Leal, W Ahmad. (2004). A novel locus for autosomal recessive form of hypotrichosis maps to chromosome 3q26.33-q27.2. Journal of Medical Genetics 41(11):849-52

66. Muhammad Arshad Rafiq, Muhammad Ansar, Saqib Mahmood, Sayedul Haque, Muhammad Faiyaz-ul-Haque, Suzanne M Leal, Wasim Ahmad. (2004). A Recurrent Intragenic Deletion Mutation in DSG4 Gene in Three Pakistani Families with Autosomal Recessive Hypotrichosis. Journal of Investigative Dermatology 123:247-248

67. Rafiq MA, Ansar M, Pham T, Amin-ud-din M, Anwar M, Haque S, Yan K, Leal SM Ahmad W (2004). Localization of a Novel Locus for Hereditary Nail Dysplasia to Chromosome 17q25.1—17q25.3. Clinical Genetics 66 :73-78

68. Muhammad Ansar, Maria H. Chahrour, Mohammad Amin ud Din, Muhammad Arshad, Sayedul Haque, Thanh L. Pham, Kai Yan, Wasim Ahmad, Suzanne M. Leal. (2004). DFNB44, a novel autosomal recessive non-syndromic hearing impairment locus, maps to chromosome 7p14.1-q11.22. Human Heredity 57:195-199 

69. Muhammad Faiyaz-Ul-Haque, Wasim Ahmad, Syed HE Zaidi, Syed Sarwar Hussain, Sayedul Haque, Mahmud Ahmad, Daniel H Cohn and Lap-Chee Tsui. (2004). Novel Mutations in Putative Tumor Suppressor Heteroligomeric Glycoprotein

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Exostosin-1 (EXT1) in 2 large Consanguineous Families affected with the Hereditary Multiple Exostosis (Familial Osteochondromatosis). Clinical Genetics 66:144-151

70. Malik S, Arshad M, Amin-Ud-Din M, Oeffner F, Dempfle A, Haque S, Koch MC, Ahmad W, Grzeschik KH (2004). A novel type of autosomal recessive syndactyly: Clinical and molecular studies in a family of Pakistani origin. American Journal of Medical Genetics 126:61-7

71. Muhammad Arshad Rafique, Muhammad Ansar, Syed Muhammad Jamal, Sajid Malik, Muhammad Sohail, Mohammad Faiyaz-Ul-Haque, Sayedul Haque, Suzanne M. Leal, Wasim Ahmad. (2003). A Locus for Hereditary Hypotrichosis localized to Human Chromosome 18q21.1. European Journal of Human Genetics 11: 623-628

72. M Wajid, AA Abbasi, M Ansar, TL Pham, K Yan, S Haque, W Ahmad and SM Leal. (2003). DFNB39, a recessive form of sensorineural hearing impairment, maps to chromosome 7q11.22. European Journal of Human Genetics 11: 812-815

73. Muhammad Ansar, Mohammad Ramzan, Thanh L. Pham, Kai Yan, Syed Muhammad Jamal, Sayedul Haque, Wasim Ahmad, Suzanne M Leal (2003). Localization of A Novel Autosomal Recessive Non- Syndromic Hearing Impairment Locus (DFNB38) to 6q26-q27 in a Consanguineous Kindred from Pakistan. Human Heredity 55:71-74

74. Ana Kljuic, Hisham Bazzi, John P Sundberg, Amalia Martinez, Ryan O’Shaughnessy, My G Mahoney, Moise Levy, Xavier Montagutelli, Wasim Ahmad, Vincent M Aita, Derek Gordon, Jouni Uitto, David Whiting, Jurg Ott, Stuart Fischer, T Conrad Gilliam, Colin A B Jahoda, Rebecca, J Morris, Andrei A Panteleyev, Vu Thuong Nguyen, Angela M Christiano. (2003). Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell 113:249-260

75. Muhammad Ansar, Mohammad Amin ud Din, Muhammad Arshad, Muhammad Sohail, Mohammad Faiyaz -Ul -Haque, Sayedul Haque, Wasim Ahmad, Suzanne M. Leal. (2003). A novel autosomal recessive non-syndromic deafness locus (DFNB35) maps to 14q24.1-14q24.3 in large consanguineous kindred from Pakistan. European Journal of Human Genetics 11:77-82

76. Faiyaz-Ul-Haque M, Ahmad W, Wahab A, Haque S, Azim AC, Zaidi SH, Teebi AS, Cohn DH, Siddique T, Tsui LC. (2002). Frameshift mutation in the cartilage- derived morphogenetic protein 1(CDMP1) gene and severe acromesomelic chondrodysplasia resembling Grebe-type chondrodysplasia. American J Medical Genetics 111: 31-7.

77. M Faiyaz-ul-Haque, W Ahmad, SHE Zaidi, S Haque, AS Teebi, DH Cohn, L-C Tsui (2002). Mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene in a kindred affected with fibular hypoplasia and complex brachydactyly (DuPan Syndrome). Clinical Genetics 61: 454-458

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78. Wasim Ahmad, Marion S. Ratterree, Andrei A. Panteleyev, John P. Sundberg and Angela M. Christiano (2002). Atrichia with popular lesions resulting from mutations in the rhesus macaque (Macaca mulatta) hairless gene. Laboratory Animals 36: 61-67

79. Martinez-Mir A, Liu J, Gordon D, Weiner MS, Ahmad W, Fine JD, Ott J, Gillian TC, Christiano AM. (2002). EB simplex superficialis from a mutation in the Type VII collagen gene. J Investigative Dermatology 118: 547-549

80. Wasim Ahmad, Sara Noci, M.Maqbool Ahmad, Tiziana Sarno, Paolo Aridon, , Mohammad Faiyaz ul Haque, Muhammad Amin-ud-din, Muhammad Arshad Rafique, Saeedul Haque, Maurizio De Fusco, Andrea Ballabio, Brunella Franco, Giorgio Casari. (2001). Linkage mapping of a non-specific form of X-linked mental retardation (MRX53) in a large Pakistan family. American Journal of Medical Genetics 15: 62-65

81. Frank J, Aita VM, Ahmad W, Lam H, Wolff C, Christiano AM. (2001). Identification of a founder mutation in the protoporphyrinogen oxidase gene in variegate porphyria patients from Chile. Human Heredity 51: 160-168

82. Frank J, Cserhalmi-Friedman PB, Ahmad W, Panteleyev AA, Aita V, Christiano AM. (2001). Characterization of the desmosomal cadherin gene family: Genomic organization of two desmoglein genes on human chromosome 18q12. Experimental Dermatology 10: 90-94

83. Cserhalmi-Friedman PB, Frank J, Ahmad W, Panteleyev AA, Aita V, Christiano AM. (2001). Structural analysis reflects the evolutionary relationship between the human desmocollin gene family members. Experimental Dermatology 10: 95-99

84. Aita VM, Ahmad W, Panteleyev AA, Kozlowska U, Kozlowska A, Gilliam TC, Jablonska S, Christiano AM, (2000). A novel missense mutation (C622G) in the zinc-finger domain of the human hairless gene associated with congenital atrichia with papular lesions. Experimental Dermatology. 9: 157-162

85. Blume-Peytavi U, Adler YD, Geilen CC, Ahmad W, Christiano A, Goerdt S, Orfanos CE. (2000). Multiple familial cutaneous glomangioma: A pedigree of 4 generations and critical analysis of histologic and genetic differences of glomus tumors. J American Academy of Dermatology 42: 633-639

86. Wasim Ahmad, Abraham Zlotogorski, Andrie A. Panteleyev, HaMut Lam, Husein M. Abdallah, Laryssa Dragan and Angela M. Christiano. (1999). Genomic organization of the human hairless gene and identification of a mutation underlying congenital atrichia in an Arab Palestinian family. Genomics 56:141-148

87. Jorge Frank, Claudio Pignata, Andrei Panteleyev, David Prowse, Howard Baden, Lordin Weiner, Lucia Gaetaniello, Wasim Ahmad, Nicola Pozzi, Peter B. Cserhalmi-Friedman, Vincent M. Aita, Hendrik Uyttendaele, Derek Gordon, Jurg

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Ott, Janice L. Brissette, Angela M. Christiano (1999). Exposing the human nude phenotype. Nature 398:473-474

88. Wasim Ahmad, Kazuo Nomura, John A. McGrath, Isao Hashmoto and Angela M. Christiano. (1999). A homozygous nonsense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia. Journal of Investigative Dermatology 113: 101-103

89. Wasim Ahmad, Maurizio De Fusco, Mohammad Faiyaz ul Haque, Paolo Aridon, Tiziana Sarno, Muhammad Sohail, Saeed ul Haque, Mahmud Ahmad, Andrea Ballabio, Brunella Franco, Giorgio Casari (1999). Linkage mapping of a new syndromic form of X-linked mental retardation associated with obesity. European Journal of Human Genetics 7: 828-832

90. Ahmad W, Panteleyev AA Christiano AM. (1999). The molecular basis of congenital atrichia in humans and mice: mutations in the hairless gene. J Investigative Dermatology 4(3): 240-243

91. Bei Liu, Wasim Ahmad, Nathan N. Aronson Jr. (1999). Structure of the human gene for lysosomal di-N-acetylchitobiase. Glycobiology 9: 589-593

92. Wasim Ahmad, Andrei Panteleyev and Angela M. Christiano. (1999). Molecular basis of congenital atrichia in humans and mice. Cutis 64: 269-276

93. Peter B. Cserhalmi-Friedman, Wasim Ahmad and Angela M Christiano. (1999). Molecular basis of hair and nail diseases In: Atlas of hair and Nails (Eds. Hordinsky M., Sawayer M and Scher R) pp 239-243

94. Jorge Frank, Jonathan nelson, Xiuhua Wang, Lin Yang,Wasim Ahmad, HaMut Lam, Frank K Jugert, Katrin Kalka, Maureen B. Poh-Fitzpatrick, Gunter Georz, Hans F Maerk and Angela M Christiano (1999). Erythropoietic protoporphyria: Identification of novel mutations in the ferrochelatase gene and comparison of biochemical markers versus molecular analysis as diagnostic strategies. Journal of Investigative Medicine 47: 278-284

95. Peter B. Cserhalmi-Friedman, Juli Grossman, Sarolta Karpati, Wasim Ahmad, Attila Horvath and Angela M Christiano (1999). Identification of a de novo glycine substitution in the type VII collagen gene in a proband with mild dystrophic Epidermolysis Bullosa. Experimental Dermatology 8: 143-145

96. Wasim Ahmad, Haque, HaMut Lam, Jason Owen, Michele deBlaquiere, Jorge A Frank, peter B. Cserhalmi Friedman, John A Mcgrath, Mahmud Ahmad, Jurg Ott and Angela M. Christiano (1998). Alopecia Universalis associated with a mutation in the human hairless gene. Science 279 : 720-724

97. Wasim Ahmad, Muhammad Faiyaz ul Haque, Valeria Brancolini, HaMut Lam, Saeed ul Haque, Mahmud Haider, Aijaz Maimon, Mahmud Ahmad, Jurg Ott and

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Angela M Christiano (1998). A Locus for Autosomal Recessive Hypodontia with Associated Dental Anomalies Maps to Chromosome 16q12.1 American Journal of Human Genetics. 62: 987-991

98. Wasim Ahmad, Andrei Panteleyev, John P. Sundberg and Angela M. Christiano (1998). Molecular Basis for the rhino (hrrh8j) Phenotype: A Nonsense Mutation in the Mouse Hairless Gene. Genomics 53: 383-386

99. Mahmud Ahmad, Muhammad Faiyaz Ul Haque, Wasim Ahmad, Hassan Abbas, Sayedul Haq, Deborah Krakow David L. Rimoin, Ralph S. Lachman and Daniel H.Cohn (1998). A Distinct, Autosomal Recessive Form of Spondyloepimetaphyseal Dysplasia Segregating in an Inbred Pakistani Kindred. 1998. American Journal of Medical Genetics 78: 468-473

100.Wasim Ahmad, Alan Invine, Hamut Lam, Colin Buckley, E. Ann Bingham, Andrei A. Panteleyev, Mahmud Ahmad, John A. McGrath and Angela M. Christiano (1998). A Missense Mutation in the Zinc-Finger Domain of the Human Hairless Gene Underlies Congenital Atrichia in a Family of Irish Travellers. American Journal of Human Genetics 63:984-991

101.Wasim Ahmad, Andrei Panteleyev, Victoria Henson-Apollonio, John P. Sundberg and Angela M. Christiano (1998). Molecular basis of a novel rhino (hr rh-Chr) phenotype: A nonsense mutation in the mouse hairless gene. Experimental Dermatology 7: 298-301

102.Andrei A. Panteleyev, Wasim Ahmad, Alexei M. Mallashenko, Elena L. Ignatieva, Ralf Paus, John P. Sundberg and Angela M. Christiano (1998). Molecular basis for the rhino Yurlovo (hr rhy) phenotype: Severe skin abnormalities and female reproductive defects associated with an Insertion in the hairless gene. Experimental Dermatology 7: 281-288

103.Andrei A. Panteleyev, Ralf Paus, Wasim Ahmad, John P. Sundberg and Angela M. Christiano (1998). Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans. Experimental Dermatology 7: 249-267

104.M. F. Ul Haque, L M. King1, D. Krakow, R. M. Cantor, M. E. Rusiniak, R. T. Swank, A. Superti-Furga, S. Haque, H. Abbas, W. Ahmad, M. Ahmad and D. H. Cohn (1998). Mutations in orthologues genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse. Nature Genetics 20: 157-162

105. Abraham Zlotogorski, Wasim Ahmad and Angela M. Christiano (1998). Congenital atrichia in five Arab Palestinian families resulting from a deletion mutation in the human hairless gene. Human Genetics 103: 400-404

106. W Ahmad, M D Fusco, M F Haque, T Sarno, P Aridon, M Ahmad, S ul Haque, A. Selicorni, C. Bedeschi, A Ballabio, B Franco, G Casari (1997). Mapping of three loci for X-linked mental retardations. American Journal of Human Genetics 61: 1540

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107. David Hughes, Jeremy Allen, Garry Morley, Kate Southerland, Wasim Ahmad, Jane Porosser, Laura Lettice, Gordon Allan, Marie-Genevieve Mattei, Martin Farral and Robert E. Hill. (1997). Cloning and sequencing of the mouse Gli2 gene: Localisation to the dominant hemimelia critical region. Genomics 39 : 205-215

108.W. Ahmad, S. Li, H. Chen, C.M. Tuck-Muller, S. J. Pittler and N.N. Aronson, Jr. (1995). Lysosomal chitobiase (CTB) and the G-protein gamma-5 subunit (GNG5) genes co-localise to human chromosome 1p22. Cytogenetics Cell Genetics 71 : 44-46

109. S. M. S. Naqvi, W. Ahmad and A. Khanum. (1993). Studies on testicular and epididymal LDH,aldolase, alkaline pyrophosphatase, acid and alkaline phosphatases in immature and mature goat (Capra hircus). Turkish Journal of Zoology 17 : 207-214

110. W. Ahmad and D. J. Ellar. (1990). Directed mutagenesis of selected regions of a Bacillus thuringiensis entomocidal protein. FEMS Microbiol. Lett. 68 : 97-104

111. D. J. Ellar, B. H. Knowles, J. carroll, J. Hornsell, M. Z. Haider, W. Ahmad, C. N. Nicholls, G. Armstrong and C. Hodgman. (1990). Genetics and biochemical studies of the mechanism of action of Bacillus thuringiensis entomocidal toxins. In: Fourth European Workshop on Bacterial Toxin. (Rappuoli, R; Alouf, J; Freer, J; Fehrrenbach, F; wadstorm, T and Witholt, B; eds), pp 499-506. Gustav Fisher, New York.

112. W. Ahmad, C. Nicholls and D. J. Ellar. (1989). Cloning and expression of entomocidal crystal protein gene from Bacillus thuringiensis galleriae toxic to both lepidopteran and dipteran larvae. FEMS Microbiol. Lett. 59 : 197-202

113.Collin N. Nicholls, Wasim Ahmad and David J. Ellar. (1989). Evidence for two different types of dual specificity insecticidal toxins in Bacillus thuringiensis subspecies. Journal of Bacteriology 171 : 5141-5147

114. Naheed Fatima, Wasim Ahmad, Azra Khanum, Roshan Ahmad and Mahmood Hussain Qazi. (1988). Effect of anticalmodulin drugs on testosteron synthesis in hCG stimulated mouse Leydig cells. Journal of Endocrinological Investigation 11 : 1-6

115. K. Jamil, A. Pal and W. Ahmad. (1989). Studies on total proteins, various enzymes, electrolytes and free amino acids in hydated cyst fluid. Pak. Vet. J. 191-193

116. Azra Khanum, Mohd. ZafarYab Haider, Wasim Ahmad and Syed Mohd. Saqlan Naqvi. (1990). Identification of androgen dependent epididymal proteins in the goat (capra hircus). Pak. J. Ind. Res. 33 : 542-545

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117. Wasim Ahmad, Syed Mohammad Saqlan Naqvi, Naheed Fatima and Azra Khanum. (1989). Isoelectric profiles of epididymal androgen dependent proteins of immature and mature goats (Capra hircus). Pak. J. Zool. 21 : 267-272

118. Anjum Ara Siddiqui, Wasim Ahmad, Naheed Fatima, Azra Khanum and Mahmood Hussaun Qazi. (1988). Purification of Leydig cells and their association with LHRH bioassay. Pak. J. Zool. 20 : 21-30

119. Azra Khanum, Naheed Fatima, Juliet lobo, Wasim Ahmad, Mohammad Salim and Mahmood Hussain Qazi. (1988). Mechanism of action of hCG using isolated mouse Leydig cells: Stimulation of DNA, chromosomal and cytosolic protein biosynthesis. Pak. J. Zool. 20 : 61-67.

120. S. M. S. Naqvi, W. Ahmad, M. Z. Haider and A. Khanum. (1987). Effect of androgen on epididymal enzymes of goat ( Capra hircus ). Pak. J. Biochem. 21: 61-67.

121. Mohd. Ishtiaq Qadri, Wasim Ahmad, Mohd. Zafaryab Haider and Azra Khanum. (1987). Mechanism of transfer of cyclic-AMP from cytoplasm to intact nuclei. Pak. J. Zool. 19 : 63-68.

122. Wasim Ahmad, Syed Mohammad Saqlan Naqvi, Mohd. Zafaryab Haider and Azra Khanum. (1987). Studies on soluble proteins in the epididymis of goat ( Capra hircus ). Pak. J. Zool. 17 : 113-125.

123. Azra Khanum, Naheed Fatima, Juliet Lobo, Wasim Ahmad, Mohammad Salim and Mahmood Hussain Qazi. (1986). Mechanism of action of hCG using isolated mouse Leydig cells: Short time biochemical events. Pak. J. Zool. 17 : 339-348.

124. Mohd. Ishtiaq Qadri, Mohd. Zafaryab Haider, Wasim Ahmad and Azra Khanum. (1985). Identification of cAMP binding proteins in Leydig cells and seminiferious tubules of mouse. Pak. J. Zool. 17 : 339-348.

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