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CURRICULUM VITAE Mark Andrew Espeland, Ph.D.

Department of Biostatistical Sciences 2215 Widgeon Court Wake Forest School of Medicine Winston-Salem, NC 27106 Winston-Salem, North Carolina 27157 336-922-2072 336-716-2826

Education

Degrees: 1974 B.S. Mathematics, Arizona State University 1976 M.A. Statistics, University of Rochester

1981 Ph.D. Statistics, University of Rochester

Honors: Arizona State University Phi Beta Kappa (1973), Phi Kappa Phi (1973)

University of Rochester Rush Rhees Fellow (1974) American Heart Association Richard D. Remington Methodology Lecturer (1996) American Statistical Association Fellow (1996) Wake Forest School of Medicine Established Investigator Clinical

Sciences Research Award (2011) American Diabetes Association Michaela Modan Memorial Award for

Outstanding Research in Epidemiology (2011)

Society for Clinical Trials Fellow (2012) Wake Forest School of Medicine Team Science Research Award

(2013) American Association for the Advancement of Science Fellow (2014) Wake Forest School of Medicine Mentoring Award (2017)

Job Experience Consultant, Alzheimer’s Therapeutics Research Institute, University of Southern California, December, 2015 to present Adjunct Professor of Statistics, Graduate Faculty, South Dakota State University, 2010-2012 Chair, Department of Biostatistical Sciences, Wake Forest University School of Medicine, February 2006 to April 2012 Associate Faculty, Women’s Health Center of Excellence, Wake Forest University School of Medicine, March 2006 to present

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Professor of Public Health Sciences (Biostatistics), Division (formerly Department) of Public Health Sciences, Wake Forest School of Medicine (formerly Bowman Gray School of Medicine), July 1994 to present Visiting Professor, Medical Statistics Unit, London School of Hygiene and Tropical Medicine, January-May, 1999

Section Head, Section of Biostatistics, Department of Public Health Sciences, Bowman Gray School of Medicine of Wake Forest University, September 1993 to 1998.

Associate Professor of Public Health Sciences (Biostatistics), Department of Public

Health Sciences, Bowman Gray School of Medicine of Wake Forest University, July 1989 to 1994

Research Associate Professor of Biometry, Department of Public Health Sciences, Bowman Gray School of Medicine of Wake Forest University, July 1987 to June 1989

Assistant Professor of Biometry, Center for Prevention Research and Biometry, Bowman Gray School of Medicine of Wake Forest University, July 1986 to July 1987

Coordinator of Biostatistics and Computing, Eastman Dental Center, October 1983 to June 1986

Assistant Director of the Statistical Coordinating Center for the Cooperative Study of Sickle Cell Disease, School of Public Health, University of Illinois at Chicago, October 1982 to October 1983

Assistant Professor of Biometry, School of Public Health, University of Illinois at Chicago, November 1981 to October 1983

Statistical Consultant--student consultant and later Assistant in Biostatistics (part time faculty appointment), University of Rochester Medical Center, June 1977 to May 1981

Instructor/Teaching Asst, University of Rochester, August 1974 to May 1977.

Publications

1. Gregg C, Cohen J, Black A, Espeland M, Feldstein M. Effects of glucose and insulin on metabolism of perfused rat kidney. American Journal of Physiology 1978;235:152-161.

2. Platt O, Rosenstock W, Espeland M. Impact of sickle hemoglobinopathies on growth and development. New England Journal of Medicine 1984;311:7-12.

3. Espeland M, Odoroff C. Log-linear models for double sampled categorical data fitted by the EM algorithm. Journal of the American Statistical Association 1985;80:663-670.

4. Pearson HA, Gallagher D, Chilcote R, Sullivan E, Wilimas J, Espeland M, Ritchey AK, et al. Developmental pattern of splenic dysfunction in sickle cell disorders. Pediatrics 1985;76:392-397.

5. Roberts CA, Tallents RH, Espeland MA, Handelman SL, Katzberg RW. Mandibular

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range of motion and arthrographic findings of TMJ patients. Oral Surgery, Oral Medicine, and Oral Pathology 1985;60:244-251.

6. Baric JM, Espeland MA, Stege PM, Saunders RH, Handelman SL. A study of nonverbal behaviors in dentists with healthy older patients using closed circuit television. Gerodontics 1985;1:170-175.

7. Zappa U, Polson A, Eisenberg A, Espeland M. Microbial populations and active tissue destruction in experimental periodontitis. Journal of Clinical Periodontology 1986;13:115-125.

8. Amato R, Caton J, Polson A, Espeland M. Interproximal gingival inflammation related to the conversion of a bleeding site to a nonbleeding site. Journal of Periodontology 1986;5:63-68.

9. Polson A, Zappa U, Espeland M, Eisenberg A. Effect of Metronidazole on development of subgingival plaque and experimental periodontitis. Journal of Periodontology 1986;57:218-224.

10. Thilo B, Caton J, Polson A, Espeland M. Cell populations associated with interdental gingival bleeding. Journal of Clinical Periodontology 1986;13:324-329.

11. Roberts C, Tallents R, Katzberg R, Sanchez-Woodworth R, Manzione J, Espeland M, Handelman S. Clinical and arthrographic evaluation of temporomandibular joint sounds. Oral Surgery, Oral Medicine, and Oral Pathology 1986;62:373-376.

12. Espeland M. A general class of models for discrete multivariate data. Communications in Statistics: Simulation and Computation 1986;15:405-424.

13. Handelman S, Baric J, Espeland M, Saunders R. Prevalence of drugs causing hyposalivation in an institutionalized geriatric population. Oral Surgery, Oral Medicine, and Oral Pathology 1986;62:26-31.

14. Stege P, Handelman S, Baric J, Espeland M. Satisfaction of the older patient with dental care. Gerodontics 1986;2:171-174.

15. Espeland M. Estimation of growth curves from longitudinal data collected at irregular time intervals. Computers and Biomedical Research 1986;19:575-587.

16. Handelman S, Stege P, Baric J, Espeland M, Saunders R. Dentists' verbal communication leads during an interview with geriatric patients. Special Care in Dentistry 1986;1;253-257.

17. Handelman SL, Leverett DH, Espeland MA, Curzon JA. Clinical radiographic evaluation of sealed carious and sound tooth surfaces. Journal of the American Dental Association 1986;113:751-754.

18. Hutta JL, Morris TW, Katzberg RW, Tallents RH, Espeland MA. Separation of internal derangements of the temporomandibular joint using sound analysis. Oral Surgery, Oral Medicine, and Oral Pathology 1987;63:151-157.

19. Handelman SL, Leverett DH, Espeland MA, Curzon J. Retention of sealants over carious and sound tooth surfaces. Community Dentistry and Oral Epidemiology 1987;15:1-5.

20. Zdanowicz J, Featherstone J, Espeland M, Curzon M. Inhibitory effect of barium on human caries prevalence. Community Dentistry and Oral Epidemiology 1987;15:6-9.

21. Westesson PL, Katzberg RW, Tallents RH, Sanchez-Woodworth RE, Svensson SA,

Espeland MA. Comparison of magnetic resonance images to cryosectional anatomy in the normal and abnormal temporomandibular joint. Radiology 1987;164:59-64.

22. Roberts CA, Tallents RH, Katzberg RW, Sanchez-Woodworth RE, Espeland MA, Handelman SL. Comparison of internal derangements of the TMJ to occlusal findings. Oral Surgery, Oral Medicine, and Oral Pathology 1987;63:645-650.

23. Espeland M, Hui S. A general approach to analyzing epidemiologic data that contain

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misclassification errors. Biometrics 1987;43:1001-1012.

24. Roberts CA, Tallents RH, Katzberg RW, Sanchez-Woodworth RE, Espeland MA, Handelman SL. Clinical and arthrographic evaluation of the location of temporomandibular pain. Oral Surgery, Oral Medicine, and Oral Pathology 1987;64:6-8.

25. Caton J, Thilo B, Polson A, Espeland MA. Cell populations associated with conversion from bleeding to nonbleeding gingiva. Journal of Periodontology 1988;59:7-11.

26. Roberts CA, Tallents RH, Katzberg RW, Sanchez-Woodworth RE, Espeland MA, Handelman SL. Comparison of arthrographic findings of the temporomandibular joint to palpation of the muscles of mastication. Oral Surgery, Oral Medicine, and Oral Pathology 1987;54:275-277.

27. Espeland M, Murphy W, Leverett D. Assessing diagnostic reliability and estimating incidence rates associated with a progressive disease: dental caries. Statistics in Medicine 1988;7:403-416.

28. Bouwsma O, Caton J, Polson A, Espeland M. Effect of oral hygiene on bleeding interdental gingiva: histologic changes. Journal of Periodontology 1988;59:80-86.

29. Meyerowitz C, Jensen OE, Espeland MA, Levy D. Third molar extraction and patient satisfaction. Oral Surgery, Oral Medicine, and Oral Pathology 1988;65:396-400.

30. Roberts CA, Katzberg RW, Tallents RH, Espeland MA, Handelman SL. Correlation of clinical parameters to the arthrographic depiction of temporomandibular joint internal derangements. Oral Surgery, Oral Medicine, and Oral Pathology 1988;66:32-36.

31. Rubens J, Espeland MA, Ryu J, Harpold G, McKinney WM, Kahl FR, Toole JF, Crouse JR. Individual variation in susceptibility to extracranial atherosclerosis. Arteriosclerosis 1988;8:389-397.

32. Zero DT, Fu J, Espeland MA, Featherstone JDB. Comparison of fluoride concentrations in unstimulated whole saliva following the use of a fluoride dentifrice and a fluoride rinse. Journal of Dental Research 1988;67(10):1257-1262.

33. Billings RJ, Meyerowitz C, Featherstone JDB, Espeland MA, Fu J, Cooper LF, Proskin HM. Retention of topical fluoride in the mouths of xerostomic subjects. Caries Research 1988;22:306-310.

34. Caton JG, Polson AM, Bouwsma OJ, Bleiden T, Frantz BJ, Espeland MA. Associations between bleeding and visual signs of interdental gingival inflammation. Journal of Periodontology 1988;59:722-727.

35. Handelman SL, Baric JM, Saunders RH, Espeland MA. Hyposalivatory drug use, whole stimulated salivary flow and mouth dryness in older, long-term care residents. Special Care in Dentistry 1989;1:12-18.

36. Espeland MA, Murphy WC, Cox C, Billings RJ, Bouwsma OJ. Rerandomization tests for analyzing correlated data from dental studies. Computers and Biomedical Research 1989;22:1-10.

37. Kofinas AD, Espeland MA, Swain M, Penry M, Nelson LH. Correcting umbilical artery flow velocity waveforms for fetal heart rate is unnecessary. American Journal of Obstetrics and Gynecology 1989;160:704-707.

38. Caton J, Bouwsma O, Polson A, Espeland M. Effects of personal oral hygiene and subgingival scaling on bleeding interdental gingiva. Journal of Periodontology 1989;60:84-90.

39. Espeland MA, Handelman SL. Using latent structure models to characterize and assess relative error in discrete measurements. Biometrics 1989;45:587-600.

40. Jarow JP, Espeland MA, Lipshultz LI. Evaluation of the azoospermic patient. Journal of Urology 1989;142:62-64.

41. Assimos DG, Boyce WH, Furr EG, Espeland MA, Holmes RP, Harrison LH, Kroovand

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RL, McCullough DL. Selective elevation of urinary enzyme levels after extracorporeal shock wave lithotripsy. Journal of Urology 1989;142:687-690.

42. Espeland MA, Platt OS, Gallagher D. Joint estimation of incidence and diagnostic error rates from irregular longitudinal data. Journal of the American Statistical Association 1989;84:972-979.

43. Ryu JE, Murros K, Espeland MA, Rubens J, McKinney WM, Toole JF, Crouse JR. Evaluation of extracranial carotid atherosclerosis extent using B-mode ultrasound in black and white patients with transient ischemic attacks. Stroke 1989;20:1133-1137.

44. Holmes RP, Craddock G, Espeland MA, Assimos DG, Dean RH. A lack of coordination in the release of urinary lysosomal and brush border enzymes following renovascular surgery. Clinica Chimica Acta 1989;186:1-10.

45. Howard G, Evans GW, Toole JF, Tell G, Rose LA, Espeland M, Truscott BL. Characteristics of stroke victims associated with early cardiovascular mortality in their children. Journal of Clinical Epidemiology 1990;43:49-54.

46. Zappa U, Simona C, Schappi P, Graf H, Espeland M. Episodic probing attachment loss in humans: histologic associations. Journal of Periodontology 1990;61:420-426.

47. Craven TE, Ryu JE, Espeland MA, Kahl FR, McKinney WM, Toole JF, McMahan MR, Thompson C, Heiss G, Crouse JR. Evaluation the associations between carotid artery atherosclerosis and coronary artery stenosis: a case-control study. Circulation 1990;82:1230-1242.

48. Espeland MA, Gallagher D, Tell GS, Davison LL, Platt OS. Reliability of Tanner stage assessments in a multi-center study. American Journal of Human Biology 1990;2:503-510.

49. Mundorff SA, Featherstone JDB, Bibby BG, Curzon MEJ, Eisenberg AD, Espeland MA: The cariogenic potential of foods. I. Caries in the rat model. Caries Research 1990;24:344-355.

50. Mundorff SA, Eisenberg AD, Leverett DH, Espeland MA, Proskin HM: Correlation between numbers of microflora in plaque and saliva. Caries Research 1990;24:312-317.

51. Espeland MA, Zappa UE, Hogan PE, Simona C, Graf H. Cross-sectional and longitudinal reliability for clinical measurement of probing loss of attachment. Journal of Clinical Periodontology 1991;18:126-133.

52. Freedman BI, Espeland MA, Heise ER, Adams PL, Buckalew VM, Canzanello VJ. Racial differences in HLA antigen frequency and hypertensive renal failure. American Journal of Hypertension 1991;4:393-398.

53. Roberts C, Katzberg KW, Tallents RH, Espeland MA, Handelman SL. The clinical predictability of internal derangements of the temporomandibular joint. Oral Surgery, Oral Medicine, and Oral Pathology 1991;71:412-414.

54. Zappa U, Reinking-Zappa M, Graf H, Espeland M. Cell populations and episodic periodontal attachment loss in humans. Journal of Clinical Periodontology 1991;18:508-515.

55. Tell GS, Ryu JE, Thompson CJ, Kahl FR, Craven TE, Espeland MA, Hagaman AP, Heiss G, Crouse JR. Comparison of hospital and neighborhood controls in a study of coronary artery disease. Journal of Clinical Epidemiology 1991;10:1097-1104.

56. Espeland MA, Davis VG, Hartwell T, Byington RP, Hire D, Probstfield J. Analysis strategies for serial multivariate ultrasonographic data. Proceedings of the Biopharmaceutical Section, American Statistical Association, 1991:208-213.

57. Evans GW, Smith ML, Espeland MA, Case LD, Craven TE. Cross-validation vs bootstrap estimates of excess error in CART. Proceedings of the Statistical Computing Section, American Statistical Association, 1991:224-226.

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58. Zappa UE, Polson AM, Espeland MA. Correlations between periodontal tissue breakdown and cell populations. Schweiz Monatsschr Zahnmed 1991;101:1279-1285.

59. Lopez JA, Espeland MA, Jarow JP. Interpretation and quantification of penile blood flow studies using duplex ultrasonography. Journal of Urology 1991;146:1271-1275.

60. Kofinas AD, Espeland MA, Penry M, Swain M, Hatjis CG. Uteroplacental doppler flow velocity waveform indices in normal pregnancy: a statistical exercise and the development of normal reference values. American Journal of Perinatology 1992:94-101.

61. Zappa UE, Polson AM, Espeland MA. Effect of Metronidazole on experimental periodontitis: cell population characteristics. Schweiz Monatsschr Zahnmed 1992;102:178-183.

62. Espeland MA, Byington RP, Hire D, Davis VG, Hartwell T, Probstfield J. Analysis strategies for serial multivariate ultrasonographic data that are incomplete. Statistics in Medicine 1992;11:1041-1056.

63. The ACAPS Group. Rationale and design for the Asymptomatic Carotid Artery Plaque Study (ACAPS). Controlled Clinical Trials 1992;13:293-314.

64. Crouse JR, Byington RP, Bond MG, Espeland MA, Sprinkle JW, McGovern M, Furberg CD. Pravastatin, lipids, and atherosclerosis in the carotid arteries: design features of a clinical trial with carotid atherosclerosis outcome. Controlled Clinical Trials 1992;13:495-506.

65. Wang WC, Grover R, Gallagher D, Espeland M, Fandal A. Developmental screening in young children with sickle cell disease: results of a cooperative study. The American Journal of Pediatric Hematology/Oncology 1993;15:87-91.

66. Freedman BI, Espeland MA, Heise ER, Evans J, Canzanello VJ. Racial variation in human leukocyte antigen frequency in insulin-dependent diabetic nephropathy. Journal of the American Society of Nephrology 1993;3:1467-1473.

67. Probstfield JL, Byington RP, Egan DA, Espeland MA, Margitic SE, Riley WA, Furberg CD. Methodologic issues facing studies of atherosclerotic change. Circulation 1993;87[suppl II]:II-74-II-81.

68. Freedman BI, Spray BJ, Heise ER, Espeland MA, Canzanello VJ. A race-controlled HLA frequency analysis in lupus nephritis. American Journal of Kidney Diseases 1993;21:378-382.

69. Espeland MA, Rushing JL, DeVault A. Estimating incidence and diagnostic error rates for bivariate progressive processes. Biometrics 1994;49:1010-1021.

70. Mundorff-Shrestha SA, Featherstone JDB, Eisenberg AD, Cowles E, Curzon MEJ,

Espeland MA, Shields CP. Cariogenic potential of foods. II. Relationship of food composition, plaque microbial counts, and salivary parameters to caries in the rat model. Caries Research 1994;28:106-115.

71. Smith SL, Colenda C, Espeland MA. Factors determining the level of anxiety state in geriatric primary care patients in a community dwelling. Psychosomatics 1994;35:50-58.

72. Furberg CD, Byington RP, Crouse JR, Espeland MA. Pravastatin, lipids and major coronary events. The American Journal of Cardiology 1994;73:1133-1134.

73. Espeland MA, Hoen H, Byington R, Howard G, Riley WA, Furberg CD. Spatial distribution of carotid intimal-medial thickness as measured by B-mode ultrasonography. Stroke 1994;25:1812-1819.

74. Furberg CD, Adams HP, Applegate WB, Byington RP, Espeland MA, Hartwell T, Hunninghake D, Lefkowitz DS, Probstfield J, Riley WA, Young B. Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Circulation 1994;90:1679-1687.

75. Crouse JR, Byington RP, Bond MG, Espeland MA, Craven TE, Sprinkle JW, McGovern ME, Furberg CD. Pravastatin, lipids, and atherosclerosis in the carotid arteries (PLAC-II).

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The American Journal of Cardiology 1995;75:455-459. 76. The PEPI Investigators. Effects of estrogen or estrogen/progestin regimens on heart

disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. JAMA 1995;273(3):199-208.

77. Appel LJ, Espeland M, Whelton PK, Dolecek T, Kumanyika S, Applegate WB, Ettinger WH, Kostis JB, Wilson AC, Lacy C, Miller ST. Trial of Nonpharmacologic Intervention in the Elderly (TONE); design and rationale of a blood pressure control trial. Annals of Epidemiology 1995;5(2):119-129.

78. Sherertz RJ, Carruth WA, Marosok RD, Espeland MA, Johnson RA, Solomon DD. Contribution of vascular catheter material to the pathogenesis of infection: the enhanced risk of silicone in vivo. Journal of Biomedical Materials Research, 1995;29:635-645.

79. Bush TL, Espeland MA, Mebane-Sims I. The Postmenopausal Estrogen/Progestin Interventions (PEPI) trial: overview. Controlled Clinical Trials 1995;16(4S)

80. Espeland MA, Bush TL, Mebane-Sims I, Stefanick ML, Johnson S, Sherwin R, Waclawiw M. Rationale, design, and conduct of the PEPI trial. Controlled Clinical Trials 1995;16:3S-19S.

81. Miller VT, Byington RL, Espeland MA, Langer R, Marcus R, Shumaker S, Stern MP. Baseline characteristics of the PEPI participants. Controlled Clinical Trials 1995;16:54S-65S.

82. Byington RP, Furberg CD, Crouse JR, Espeland MA, Bond MG. Pravastatin, lipids, and atherosclerosis in the carotid arteries (PLAC-II). American Journal of Cardiology 1995;76:54C-59C.

83. Probstfield JL, Margitic SE, Byington RP, Espeland MA, Furberg CD for the ACAPS Research Group. Results of the primary outcome measure and clinical events from the Asymptomatic Carotid Artery Progression Study. American Journal of Cardiology 1995;76:47C-53C.

84. Espeland MA, Applegate W, Furberg CD, Lefkowitz D, Rice L, Hunninghake D. Estrogen replacement therapy and progression of intimal-medial thickness in the carotid arteries of postmenopausal women. American Journal of Epidemiology 1995;142:1011-1019.

85. Covitz W, Espeland M, Gallagher D, Geer M, Hellenbrand W, Leff S, Talner N. The heart in sickle cell anemia: The Cooperative Study of Sickle Cell Disease (CSSCD). Chest 1995;108:1214-1219.

86. Smith JA, Espeland MA, Bellevue BR, Bonds D, Brown A, Dosik H, Koshy M, Phillips G, Sleeper L for the Cooperative Study of Sickle Cell Disease. Pregnancy in sickle cell disease: report from a large multi-center longitudinal study -- The Cooperative Study of Sickle Cell Disease. Obstetrics and Gynecology 1996;87:199-204.

87. Espeland MA, Craven TE, Riley WA, Corson J, Romont A, Furberg CD. Reliability of longitudinal ultrasonographic measurements of carotid intimal-medial thicknesses. Stroke 1996;27:480-485.

88. Dolecek TA, Bradham KH, Espeland MA, Margitic SE, Byington RP, Hoen H for the ACAPS group. Recruitment efforts are maximized in a drug lipid-lowering trial with dietary intervention to lower low density lipoprotein cholesterol. Controlled Clinical Trials 1996;17:33-45.

89. Miller ME, James MK, Langefeld CD, Espeland MA, Freedman JA, Martin DK, Smith DM. Some techniques for the analysis of work sampling data. Statistics in Medicine 1996;15:607-618.

90. Espeland MA, Kumanyika S, Kostis JB, Algire J, Applegate WB, Ettinger W, Whelton PK, Bahnson J. Antihypertensive medication use among recruits for the Trial Of

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Nonpharmacologic Interventions in the Elderly. Journal of the American Geriatric Society 1996;44:1183-1189.

91. Barrett-Connor E, Schrott HG, Greendale G, Kritz-Silverstein D, Espeland MA, Stern MP, Bush T, Perlman JA. Factors associated with glucose and insulin levels in healthy postmenopausal women. Diabetes Care 1996;19:333-340.

92. Cefalu CA, Ettinger WH, Espeland M. A study of the characteristics of the dementia patients and caregivers in dementia-specific adult day-care programs. Journal of the American Geriatrics Society 1996;44:654-659.

93. Judd HL, Wasilauskas C, Johnson S, Merino M, Barrett-Connor E, Trabal J, et al. Effects of hormone replacement therapy on endometiral histology in postmenopausal women - the Postmenopausal Estrogen Progestin Interventions (PEPI) trial. JAMA 1996;275:370-375.

94. Whelton PK, Bahnson J, Appel LJ, Charleston J, Cosgrove N, Espeland MA, Folmar S, Hoaglund D, Krieger S, Lacy C, Lichtermann L, Oates-Williams F, Tayback M, Wilson AC. Recruitment in the Trial of Non-pharmacologic Interventions in the Elderly. Journal of the American Geriatrics Society 1997;45:185-193.

95. Espeland MA, Stefanick ML, Kritz-Silverstein D, Fineberg SE, Waclawiw MA, James, MK, Greendale G. Effect of postmenopausal hormone therapy on body weight and waist and hip girths. Journal of Clinical Endocrinology and Metabolism 1997;82:1549-1556.

96. Barrett-Connor E, Slone S, Greendale G, Kritz-Silverstein D, Espeland M, Johnson SR, Waclawiw M, Fineberg E. The Postmenopausal Estrogen/Progestin Interventions Study: Primary outcomes in adherent women. Maturitas 1997:27:261-274.

97. Greendale GA, James MK, Espeland MA, Barrett-Connor E. Prior postmenopausal estrogen/progestin use -- can we measure it? Results from the Postmenopausal Estrogen/Progestin Interventions study. American Journal of Epidemiology 1997;146:763-770.

98. Bahnson JL, Whelton PK, Appel LJ, Espeland MA, Wofford J, Rosen R, Wilson AC, Lacy C, Rutan G, Hogan P, Tayback M, Dolecek T, Shindler D. Baseline characteristics of randomized participants in the Trial of Nonpharmacologic Intervention in the Elderly (TONE). Disease Management and Clinical Outcomes 1997;1:61-68.

99. Langer RD, Pierce JJ, O'Hanlan KA, Johnson SR, Espeland MA, Trabal JF, Barnabie VM, Trabal JF, Merino MJ, Scully RE. Transvaginal ultrasound compared with histopathology for the detection of endometrial disease in participants in the PEPI trial. New England Journal of Medicine 1997;337:1792-1798.

100. Espeland MA. Cardioprotective effects of postmenopausal hormone treatment. American Journal of Cardiology 1998;82(10A):37s-39s.

101. Espeland MA, Hogan PE, Fineberg SE, Howard D, Schrott H, Waclawiw MA, Bush TL. Effect of postmenopausal hormone therapy on glucose and insulin concentrations. Diabetes Care 1998;21:1589-1595.

102. Espeland MA, Marcovina S, Sherwin R, Wood P, Bush T, Schrott H, Miller V. Impact of postmenopausal hormone therapy on Lp(a) concentrations. Circulation 1998;97:979-986.

103. Shumaker SA, Melton BA, Espeland MA, Rapp SR, McBee WL, Dailey M, Bowen D, Terrell T, Jones BN. The Women's Health Initiative Memory Study (WHIMS): A trial of the effect of estrogen therapy in preventing and slowing progression of dementia. Controlled Clinical Trials 1998;19:604-612.

104. Whelton PK, Appel LJ, Espeland MA, Applegate WB, Ettinger WH, Kostis JB, Kumayika S, Lacy CR, Johnson KC, Folmar S, Cutler JA. Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled Trial of Nonpharmacologic Interventions in the Elderly (TONE). JAMA 1998;279:839-846.

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105. Legault C, Espeland MA, Wasilauskas CH, Bush TL, Trabal J, Judd HJ, Johnson SR, Greendale GA. Agreement in assessing endometrial pathology: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. Journal of Women’s Health 1998;7:435-442.

106. Kostis J, Espeland MA, Appel LA, Johnson K, Lacy C, Miller S, Pierce J, Schaffhauser D, Wofford J. Does withdrawal of antihypertensive medication increase the risk of cardiovascular events? American Journal of Cardiology 1998;82:1501-1508.

107. Reboussin BA, Greendale GA, Espeland MA. The effect of hormone replacement therapy on self-report cognitive symptoms: results from the Postmenopausal Estrogen/Progestin Interventions (PEPI) trial. Climacteric 1998;1:172-179.

108. Adams RJ, McKie VC, Hsu L, Vichinsky E, Pegelow C, Abboud M, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. New England Journal of Medicine 1998;339:5-11.

109. Espeland MA, Craven TE, Miller ME, D’Agostino R. 1996 Remington Lecture: Modeling multivariate longitudinal data that are incomplete. Annals of Epidemiology 1999;9:196-205.

110. Espeland MA, Whelton PK, Kostis JB, Bahnson JL, Ettinger WE, Cutler JA, Appel LJ, Kumanyika S, Farmer D, Elam J, Wilson AC, Applegate WB. Predictors and mediators of successful long-term withdrawal from antihypertensive medications. Archives of Family Medicine 1999;8:228-236.

111. Espeland MA, Tang R, Terry JG, Davis SH, Mercuri M, Crouse JR. Associations of risk factors with segment-specific intimal-medial thickness of the extracranial carotid artery. Stroke 1999;30:1047-1955.

112. Genuth S, Nathan D, Shamoon H, Duffy H, Dahms B, Mayer L, et al. Epidemiology of Diabetes Interventions and Complications (EDIC): Design, implementation, and preliminary results of a long-term follow-up of the Diabetes Control and Complications Trial cohort. Diabetes Care 1999;22:99-111.

113. Byington RP, Evans GW, Espeland MA, Applegate WB, Hunninghake DB, Probstfield J, Furberg CD. Effects of lovastatin and warfarin on early carotid atherosclerosis: sex-specific analysis. Circulation 1999;100:e14-e17.

114. Whiteman A, Cui Y, Flaws JA, Espeland M, Bush TL. Low fibrinogen level: a predisposing factor for venous thromboembolic events with hormone replacement therapy. American Journal of Hematology 1999;61:271-273.

115. Chao D, Espeland MA, Farmer D, Register TC, Lenchek L, Folmar S, Ettinger WH. Effect of voluntary weight loss on bone mineral density in older overweight women. Journal of the American Geriatrics Society 2000;48:753-759.

116. Barrett-Connor E, Espeland MA, Greendale GA, Trabal J, Johnson S, Legault C, Kritz-Silverstein D, Einhorn P. Postmenopausal hormone use following a three-year randomized clinical trial. Journal of Women’s Health 2000;9:633-643.

117. Mazure CM, Espeland M, Douglas P, Champion V, Killien M. Multidisciplinary women’s health research: The National Centers of Excellence in Women’s Health. Journal of Women’s Health 2000,9:717-724.

118. Shannon H, Duffy H, Dahms W, Mayer L, Brillion D, Lackaye M, et al. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. New England Journal of Medicine 2000;342:381-389.

119. Chao D, Farmer DF, Sevick MA, Espeland MA, Vitolins M, Naughton MJ. The value of session attendance in a weight-loss intervention. American Journal of Health Behavior 2000;24(6):413-421.

120. Espeland MA, Kumanyika S, Wilcox S, Wilson AC, Chao D, Bahnson J, Reboussin DM,

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Easter L, Zheng B. Lifestyle interventions influence relative errors in self-reported dietary measures. Annals of Epidemiology 2001;22:85-93.

121. Appel LJ, Espeland MA, Easter L, Wilson AC, Folmar S, Lacy CR. Effects of reduced sodium intake on hypertension control in older individuals. Archives of Internal Medicine 2001;161:685-693.

122. Espeland MA, Kumanyika S, Wilson AC, Reboussin DM, Easter L, Self M, Robertson J, Brown WM, McFarlane M. Statistical issues in analyzing 24-hour diet recall and 24-hour urine collection data for sodium and potassium. American Journal of Epidemiology 2001;153:996-1006.

123. Activity Counseling Trial Research Group. Effects of physical activity counseling in primary care. The Activity Counseling Trial: a randomized controlled trial. JAMA 2001;286:677-687.

124. Miller ME, Morgan TM, Espeland MA, Emerson SS. Group comparisons involving missing data in clinical trials: a comparison of estimates and power (size) for some simple approaches. Statistics in Medicine 2001;20:2383-2397.

125. Herrington DM, Fan L, Drum M, Riley WA, Pusser BE, Crouse JR, Burke GL, McBurnie

MA, Morgan TM, Espeland MA. Brachial flow-mediated vasodilator responses in population based research: reproducibility and effects of age, gender and baseline diameter. Journal of Cardiovascular Risk 2001;8:319-328.

126. Herrington DM, Espeland MA, Crouse JR, Robertson J, Riley WA, McBurnie MA, Burke GL. Effects of estrogen replacement on brachial artery flow-mediated vasodilation in older women. Atherosclerosis, Thrombosis, and Vascular Biology 2001;21:1955-1961.

127. Pineau BC, Paskett ED, Chen GJ, Durkalski VL, Espeland MA, Vining DJ. Validation of virtual colonoscopy in the detection of colorectal polyps and masses: rationale for proper study design. Journal of Gastrointestinal Cancer 2001;30:133-140.

128. Kumanyika S, Espeland MA, Bahnson JL, Bottom JB, Charleston JB, Folmar S, Wilson AC, Whelton PK. Ethnic differences in patterns of weight loss in the Trial of Nonpharmacologic Interventions in the Elderly (TONE) Obesity Research 2002;10:96-106.

129. Crouse JR, Tang R, Espeland MA, Terry JG, Morgan T, Mercuri M. Associations of extrcranial carotid atherosclerosis progression with coronary status and risk factors in patients with and without coronary artery disease. Circulation 2002;106:2061-2066.

130. Greendale GA, Espeland M, Slone S, Marcus R, Barrett-Connor E. Bone mass response to discontinuation of long-term hormone replacement therapy. Archives of Internal Medicine 2002;162:665-672.

131. Espeland MA, Kumanyika S, Yunis C, Zheng B, Brown WM, Jackson S, Wilson AC, Bahnson J, Appel LJ. Electrolyte intake and nonpharmacologic blood pressure control. Annals of Epidemiology 2002;12:587-595.

132. Kostis JB, Wilson AC, Hooper WC, Harrison KW, Philipp CS, Appel LJ, Espeland MA, Folmar S, Johnson KC. Association of angiotensin-converting enzyme DD genotype with blood pressure sensitivity to weight loss. American Heart Journal 2002;144:625-629.

133. Rapp SR, Espeland MA, Hogan P, Jones BN, and Dugan E for the WHIMS Investigators. Baseline experience with the Modified Mini-Mental State Exam: The Women's Health Initiative Memory Study (WHIMS) Aging and Mental Health 2003; 7:217-223.

134. Terry JG, Tang R, Espeland MA, Davis DH, Viera JLC, Mercuri M, Crouse JR. Compensatory remodeling of carotid arteries in participants with documented coronary artery disease (CAD) and disease-free controls. Circulation 2003;107:1146-1151.

135. Rapp SR, Espeland MA, Shumaker SA, Henderson VW, Brunner RL, Manson JE, Gass

11

MLS, Stefanick ML, Lane DS, Hays J, Johnson KC, Coker LH, Dailey M, Bowen D. Effect of estrogen plus progestin on global cognitive function in postmenopausal women: Women’s Health Initiative Memory Study: a randomized controlled trial. JAMA 2003;20:2663-2672.

136. Wagenknecht LE, Zaccaro D, Espeland MA, Karter A, O’Leary DH, Haffner SM. Diabetes progression of carotid atherosclerosis: The Insulin Resistance Atherosclerosis Study. Atherosclerosis, Thrombosis, and Vascular Biology 2003;23:1035-1041.

137. Pineau BC, Paskett E, Vining D, Mikulaninec C, Han J, Chen JG, Espeland MA, Phillips K. Virtual colonscopy using oral contrast compared with colonoscopy for the detection of patients with colorectal polyps. Gasteroenterology 2003;125:304-310.

138. Harper MA, Meyer R, Espeland MA, Naughton M, Byington R. Pregnancy related death and health care services: an epidemiological study from North Carolina. Obstetrics and Gynecology 2003;102:273-278.

139. The Look AHEAD Research Group. Look AHEAD: Action for Health in Diabetes. Design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Controlled Clinical Trials 2003;24:610-28.

140. Harris JP, Weisman MH, Derebery JM, Espeland MA, Gantz BJ, Gulya AJ, Hammerschlag PE, Hannley M, Hughes GB, Moscicki R, Nelson RA, Niparko JK, Rauch SD, Telian SA, Brookhouser PA. Treatment of corticosteroid-responsive autoimmune inner ear disease with methotrexate. JAMA 2003;290:1875-1883.

141. Espeland MA, Wagenknecht LE, Evans GE, Zaccaro D, Crouse JR, O’Leary DH, Howard G, Haffner SM, Haffner SM. Site-specific progression of carotid artery atherosclerosis. Atherosclerosis 2003;171:137-143.

142. Harper MA, Espeland MA, Dugan E, Meyer R, Lane K, Williams S. Racial disparity in pregnancy-related mortality. Annals of Epidemiology 2004;14:274-279.

143. Loehr LR, Espeland MA, Sutton-Tyrrell K, Burke GL, Crouse JR, Herrington DM. Racial differences in endothelial function in postmenopausal women. American Heart Journal 2004;148:606-611.

144. Espeland MA, Rapp SR, Shumaker SA, Brunner R, Manson JE, Sherwin BB, Hsai J, Margolis KL, Hogan PE, Wallace R, Dailey M, Freeman R, Hays J. Conjugated equine estrogens and global cognitive function in postmenopausal women. JAMA 2004;291:2959-2968.

145. Espeland MA, Rapp SR, Shumaker SA, Brunner R, Manson JE, Sherwin BB, Hsia J, Margolis KL, Hogan PE, Wallace R, Dailey M, Freeman R, Hays J. Conjugated equine estrogens and global cognitive function in Postmenopausal Women: Women's Health Initiative Memory Study. Obstetrical and Gynecological Survey 2004;59(10):712-714.

146. Resnick SM, Coker LH, Maki PM, Rapp SR, Espeland MA, Shumaker SA. The Women’s Health Initiative Study of Cognitive Aging (WHISCA): a randomized clinical trial of the effects of hormone therapy on age-associated cognitive decline. Clinical Trials 2004;1:440-450.

147. Espeland MA, Gu L, Masaki KH, Langer RD, Coker LH, Stefanick ML, Ockene J, Rapp

SR. Association between reported alcohol intake and changes in cognition: Results from the Women’s Health Initiative Memory Study (WHIMS). American Journal of Epidemiology 2005;161:228-238.

148. Reboussin D, Espeland MA. The science of web-based clinical trial management. Clinical Trials 2005;2:1-2.

149. Espeland MA, O’Leary DH, Terry JG, Morgan T, Evans G, Mudra H. Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors. Current Controlled Trials in Cardiovascular Medicine 2005;6:3

12

(http://cvm.controlled-trials.com). (PMCID: PMC555546) 150. Terry JG, Carr JJ, Tang R, Evans GW, Kouba EO, Shi R, Cook DR, Vieira JLC,

Espeland MA, Mercuri MF, Crouse JR. Coronary artery calcium (CAC) outperforms carotid intima-media thickness (IMT) as a non-invasive index of prevalent coronary artery disease (CAD). Arteriosclerosis, Thrombosis, and Vascular Biology 2005;25:1723-1728.

151. Niparko JK, Wang N-Y, Rauch SD, Russell GB, Espeland MA, Pierce JP, Bowditch S, Masuda A, Gulya JA, Gantz BJ, Hughes GB, Brookhouser PE, Telian SA, The AIED Study Group, Harris JP. Serial audiometry in a clinical trial of AIED treatment. Otology and Neurotology 2005;26:908-917.

152. Espeland MA, Rapp SR, Robertson R, Granek I, Murphy C, Albert M, Bassford T. Benchmarks for designing two-stage studies using Modified Mini-Mental State Examinations: Experience from the Women’s Health Initiative Memory Study. Clinical Trials 2006;3:99-106.

153. Resnick SM, Maki PM, Rapp SR, Espeland M, Brunner R, Coker L, Granek I, Hogan P, Ockene J, Shumaker SA. Effects of combination estrogen plus progestin hormone treatment on cognition and affect: The Women’s Health Initiative Study of Cognitive Aging (WHISCA) Journal of Endocrinology and Clinical Metabolism 2006;91:1802-10.

154. Espeland MA, Coker LH, Wallace R, Rapp SR, Resnick SM, Limacher M, Powell L, Messina CR. Association between alcohol intake and domain-specific cognitive function Neuroepidemiology 2006;27:1-12.

155. The Look AHEAD Research Group. Baseline characteristics of the randomized cohort from the Look AHEAD (Action of Health in Diabetes) study. Diabetes and Vascular Disease Research 2006;3:202-215.

156. The Look AHEAD Research Group. The Look AHEAD Study: A description of the lifestyle intervention and the evidence supporting it. Obesity 2006;14:737-752.

157. Espeland MA, Dotson K, Jaramillo SA, Kahn SE, Harrison B, Montez M, Foreyt J, Montgomery B, Knowler WC. Consent for genetics studies among clinical trial participants: Findings from Action for Health in Diabetes (Look AHEAD). Clinical Trials 2006;3:1-14.

158. The LIFE Study Investigators. Effects of a physical activity intervention on measures of physical performance: results of the Lifestyle Interventions and Independence in Elders (LIFE) pilot study. Journal of Gerontology: Medical Sciences 2006;61A:1157-1165.

159. Espeland MA, Henderson VW. Preventing cognitive decline in usual aging. Archives of Internal Medicine 2006;166:2433-2434.

160. Look Ahead Research Group. Baseline characteristics of the randomised cohort from the Look AHEAD (Action for Health in Diabetes) Research Study. Diabetes and Vascular Disease Research 2006;3(3):202-15.

161. Chambers MS, Fleming TJ, Toth BB, Lemon JC, Craven TE, Bouwsma OJ, Garden AS,

Espeland MA, Keene HJ, Martin JW, Sipos T. Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects: Part 2 (Phase 1 Study). Oral Oncology 2007;43:98-195.

162. Harper M, Dugan E, Espeland M, Martinez-Borges A, McQuellon C. Why African American women are at greater risk for pregnancy-related death. Annals of Epidemiology 2007;17:180-185.

163. Jaramillo SA, Felton D, Andrews LA, Desiderio L, Hallarn RK, Jackson SD, Coker LH,

Robinson JG, Ockene JK, Espeland MA. Enrollment in a brain magnetic resonance study: results from the Women’s Health Initiative Memory Study Magnetic Resonance Imaging Study (WHIMS-MRI). Academic Radiology 2007;14;603-612.(PMCID:

PMC1934046)

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164. Look AHEAD Research Group. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the Look AHEAD Trial. Diabetes Care 2007;30:1374-1383.

165. Espeland MA, Gill TM, Guralnik, Miller ME, Fielding R, Newman AB, Pahor M. Designing clinical trials of intervention for mobility disorder: results from the Lifestyle Interventions and Independence for Elders Study Group. Journal of Gerontology: Medical Sciences 2007;62A;1237-1243. PMCID: PMC2376827

166. Bhasin S, Cress E, Espeland MA, Evans WJ, Ferrucci L, Fried LP, Gill TM, Pahor M, Studenski S, Guralnik J, et al. (Working Group on Functional Outcome Measures for Clinical Trials). Functional outcomes for clinical trials in frail older persons: time to be moving. Journal of Gerontology: Medical Sciences 2008;63A:160-164.

167. Espeland MA, Regensteiner JG, Jaramillo SA, Gregg E, Knowler W, Wagenknecht LE, Bahnson J, Haffner S, Hill J, Hiatt WR. Measurement characteristics of the ankle-brachial index: Results from the Action for Health in Diabetes Study. Vascular Medicine 2008;13:225-233.

168. Cann JA, Register TC, Adams MR, St. Clair RW, Espeland MA, Williams JK. Timing of estrogen replacement influences atherosclerosis progression and plaque leukocyte populations in ApoE-/- mice. Atherosclerosis 2008;201(1):43-52 (2008:doi:10.1016/j.atherosclerosis 2008.01.018).

169. Johnson KC, Margolis KL, Espeland MA, Colenda CC, Fillit H, Manson JE, Masaki KH, Mouton SP, Prineas R, Robinson JG, Wassertheil-Smoller S. A prospective study of the effect of hypertension and baseline blood pressure on cognitive decline and dementia in postmenopausal women: the Women’s Health Initiative Memory Study. Journal of the American Geriatrics Society 2008;56(8):1449-58 (DOI:10.101111/j.1532-5415.2008.01806.x).

170. Underhill HR, Yuan C, Terry JG, Chen H, Espeland MA, Hatsukami TS, Saam T, Chu B, Yu W, Oikawa M, Takaya N, Yarnykh VL, Kraft R, Carr JJ, Maldjian J, Tang R, Crouse JR. Differences in carotid arterial morphology and composition between patients with and without obstructive coronary artery disease: a cardiovascular magnetic resonance study. Journal of Cardiovascular Magnetic Resonance 2008;10(1):31 (d0i:10.1186/1532-492X-10-31:1-11).

171. Resnick SM, Espeland MA, Jaramillo SA, Hirsch C, Stefanick ML, Murray AM, Ockene J, Davatzikos C. Postmenopausal hormone therapy and regional brain volume: The WHIMS-MRI Study. Neurology 2009;72:135-142.

172. Vestergaard S, Patel KV, Walkup MP, Pahor M, Marsh AP, Espeland MA, Studenski S, Gill TM, Church T, Guralnik JM. Stopping to rest during a 400-meter walk at baseline and incident mobility disability in older persons with functional limitations. Journal of the American Geriatrics Society 2009;57:260-265.

173. Rejeski WJ, Marsh AP, Chmelo E, Prescott AJ, Dobrosielski M, Walkup M, Espeland M, Miller ME, Kritchevsky S. The Lifestyle Interventions and Independence for Elders Pilot (IPE-P): Two-year follow-up. Journal of Gerontology: Medical Sciences 2009;64A:462-467.

174. Williamson JD, Espeland M, Kritchevsky SB, Newman AB, King AC, Pahor M, Guralnik JM, Pruitt LA, Miller ME. Changes in cognitive function in a randomized trial of physical activity: results from the Lifestyle Interventions and Independence for Elders (LIFE) pilot study. Journal of Gerontology: Medical Sciences 2009;64A:688-694.

175. Bhasin S, Espeland MA, Evans WJ, Ferrucci L, Freid LP, Gill TM, Pahor M, Studenski S, Guralnik J, Nayfi S, et al. (Working Group on Functional Outcome Measures for Clinical Trials). Indications, labeling, and outcomes assessment for drugs aimed at improving

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functional status in older persons: A conversation between aging researchers and FDA regulators. Journal of Gerontology: Medical Sciences 2009;64A:487-91.

176. Alexander TH, Weisman MH, Derebery JM, Espeland MA, Gantz BJ, Guyla AJ, Hammerschlag PE, Hannley M, Hughes GB, Moscicki R, Nelson RA, Niparko JK, Rauch SD, Telian SA, Brookhouser PE, Harris JP. Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease. Otology and Neurotology 2009;30:443-448.

177. Espeland MA, Tindle HA, Bushnell CA, Jaramillo SA, Kuller LH, Margolis KL, Mysiw WJ, Maldjian JA, Melhem ER, Resnick SM. Brain volumes, cognitive impairment, and conjugated equine estrogens. Journal of Gerontology: Medical Sciences 2009;64A:1243-50 (PMID: 19729392).

178. Phelan S, Kanaya AM, Subak LL, Hogan P, Espeland MA, Wing RR, Burgio KL, DiLillo V, Gorin A, West D, Brown JS. Prevalence and risk factors for urinary incontinence in diabetic women: the Look AHEAD study. Diabetes Care 2009;32:1391-1397.

179. Espeland MA, Bray GA, Neiberg R, Rejeski WJ, Knowler WC, Lang W, Cheskin LJ, Williamson D, Lewis CB, Wing R. Describing patterns of weight changes using principal components analysis: results from the Action for Health in Diabetes (Look AHEAD) Research Group. Annals of Epidemiology 2009;19:701-710 (NIHMS[128428]).

180. Ding J, Hsu FC, Harris T, Liu Y, Kritchevsky S, Szklo M, Ouyang P, Espeland M, Lohman K, Criqui M, Allison M, Bluemke D, Carr JJ. The association of pericardial fat with incident coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA). American Journal of Clinical Nutrition 2009;40:499-504.

181. Mount DL, Feeney P, Fabricatore AN, Coday MA, Bahnson J, Byington R, Phelan S,

Wilmoth S, Knowler WC, Hramiak I, Osei K, Sweeney ME, Espeland MA. Constructing common cohorts from trials with overlapping eligibility criteria from comparing effect sizes between trials: results from the Look AHEAD and ACCORD trials. Clinical Trials 2009;6:416-429. PMIC: 19737845

182. Resnick SM, Espeland MA, An Y, Maki PM, Coker LH, Jackson R, Stefanick SML, Wallace R, Rapp SR. Effects of conjugated equine estrogens on cognition and affect in postmenopausal women with prior hysterectomy. Journal of Clinical Endocrinology and Metabolism 2009;94:4152-61.

183. Atkinson HH, Rapp SR, Williamson JD, Lovato J, Absher JR, Gass M, Henderson VW,

Johnson KC, Kostis JB, Mouton C, Ockene JK, Stefanick JL, Lane DS, Espeland MA. The relationship between cognitive function and physical performance in older women: results from the Women’s Health Initiative Memory Study (WHIMS). Journal of Gerontology: Medical Sciences 2010;65A(3):300-6.

184. Coker LH, Espeland MA, Rapp SR, Legault C, Resnick SM, Hogan P, Jaramillo S, Dailey M, Shumaker SA. Postmenopausal hormone therapy and cognitive outcomes: the Women’s Health Initiative Memory Study (WHIMS). Journal of Steroid Biochemistry and Molecular Biology 2010;118:304-310.

185. Katula JA, Vitolins MZ, Rosenberger EL, Blackwell C, Espeland MA, Rejeski WJ, Goff DC. Healthy Living Partnerships to Prevent Diabetes (HELP PD): design and methods. Contemporary Clinical Trials 2010;31(1):71-81. Doi:10.1016//j.cct.2009.09.002.

186. Tooze JA, Gaussoin SA, Resnick SM, Fischbein NJ, Robinson JG, Bryan RN, An Y,

Espeland MA. A uniform approach to modeling risk factor relationships for ischemic lesion prevalence and extent: The Women’s Health Initiative Magnetic Resonance Imaging Study (WHIMS-MRI). Neuroepidemiology 2010;34:55-62.

187. Curtis JM, Horton ES, Bahnson J, Gregg EW, Jakicic JM, Regensteiner JG, Ribisl PM,

Soberman JE, Stewart KJ, Espeland MA. Prevalence and predictors of abnormal cardiovascular responses to exercise testing among persons with type 2 diabetes.

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Diabetes Care 2010;33:910-907.

188. Espeland MA, Shumaker SA, Limacher M, Rapp SR, Bevers TB, Barad DH, Coker LH, Jaramillo SA, Stefanick ML, Lane DS, Maki PM, Resnick SM. Relative effects of tamoxifen, raloxifene, and conjugated equine estrogens on cognition. Journal of Women’s Health 2010;19:371-379.

189. Burdette JH, Laurienti PJ, Espeland MA, Morgan AR, Telesford Q, Vechlekar CD, Hayasaka S, Jennings JJ, Katula JA, Kraft RA, Rejeski WJ. Using network science to evaluate exercise-associated brain changes in older adults. Frontiers in Aging Neuroscience 2010;2:article23 (doi 10.3389/nagi.2010.00023).

190. Kerwin D, Zhang Y, Kotchen JM, Espeland MA, van Horn L, McTique KM, Robinson JG, Powell L, Kooperberg C, Coker LH, Hoffman R. The cross-sectional relationship between body mass index and cognitive function in postmenopausal women enrolled in the Women’s Health Initiative (WHI). Journal of the American Geriatrics Society, 2010;28:1427-1432. PMCID: PMC2955186

191. Espeland MA, Brunner RL, Hogan PA, Rapp SR, Coker LH, Legault C, Granek I, Resnick SM. Long term effects of conjugated equine estrogens therapies on domain-specific cognitive function: Results from the Women’s Health Initiative Study of Cognitive Aging (WHISCA) Extension. Journal of the American Geriatrics Society 2010;58:1263-1271. PMID:20649689

192. Look AHEAD Research Group. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four year results of the Look AHEAD trial. Archives of Internal Medicine 2010;170:1566-1575.

193. Kerwin DR, Gaussoin SA, Chlebowski RT, Kuller LH, Vitolins M, Coker LH, Kotchen JM,

Nicklas BJ, Wassertheil-Smoller S, Hoffmann RG, Espeland MA. Interaction between body mass index and central adiposity and risk of incident cognitive impairment and dementia: results from the Women’s Health Initiative Memory Study. Journal of the American Geriatrics Society 2011:59:107-112.

194. Goveas JS, Espeland MA, Woods NF, Wassertheil-Smoller S, Kotchen JM. Depression and incidence of mild cognitive impairment and dementia in elderly women: The Women’s Health Initiative Memory Study. Journal of the American Geriatrics Society 2011;59:57-66.

195. Espeland MA, Rapp SR, Katula JA, Andrews LA, Felton D, Gaussoin SA, Dagenbach D, Legault C, Jennings JM, Sink KM. Telephone Interview for Cognitive Status (TICS) screening for clinical trials of physical activity and cognitive training: The Seniors Health and Activity Research Program Pilot (SHARP-P) Study. International Journal of Geriatric Psychiatry 2011;26:135-143.

196. Casanova R, Espeland MA, Goveas JS, Davatzikos C, Gaussoin SA, Maldjian JA, Brunner RL, Kuller LH, Johnson KC, Mysiw WJ, Wagner B, Resnick SM. Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes. Magnetic Resonance Imaging 2011;29:546-553. (PMID: 21292420)

197. Shih RA, Ghosh-Dastidar B, Margolis K, Slaughter ME, Jewell A, Bird CE, Eibner C,

Denburg NL, Ockene J, Messina CR, Espeland MA. Neighborhood socioeconomic status and cognitive function in women. American Journal of Public Health 2011;101:1721-1728. doi:10.2105/AJPH.2011.300169. PMCID: PMC3154213

198. Driscoll I, Espeland MA, Wassertheil-Smoller S, Gaussoin SA, Ding J, Granek I, Ockene JK, Phillips LS, Yaffe K, Resnick SM. Weight change and domain-specific cognitive function. Findings from the Women’s Health Initiative Study of Cognitive Aging. Obesity 2011;19:1595-1600 (PMID: 21394095).

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199. Goveas JS, Espeland MA, Hogan P, Dotson V, Tarima S, Coker LH, Ockene J, Brunner R, Woods NF, Wassertheil-Smoller S, Kotchen J, Resnick S. Depressive symptoms, brain volumes, and subclinical cerebrovascular disease in postmenopausal women: The Women’s Health Initiative MRI Study. Journal of Affective Disorders 2011:132:275-284.

200. Legault C, Jennings JM, Katula JA, Dagenbach D, Gaussoin SA, Sink KM, Rapp SR,

Rejeski JR, Shumaker SA, Espeland MA. Designing clinical trials for assessing the effects of cognitive training and physical activity interventions on cognitive outcomes: the Seniors Health and Activity Research Program Pilot Study. BMC Geriatrics 2011;11:27. (EPub May 26;11(1):27). PMCID: PMC3126708

201. Shea MK, Nicklas BJ, Houston DK, Miller ME, Davis CC, Kitzman DW, Espeland MA, Appel LJ, Kritchevsky SB. The effect of intentional weight loss on all-cause mortality in older adults: results of a randomized-controlled weight loss trial. American Journal of Clinical Nutrition 2011;94:839-846. (doi: 10.3945/ajcn.110.006379)

202. Espeland MA, Miller ME, Goveas JS, Hogan PA, Coker LH, Williamson JD, Naughton MJ, Resnick SM. Cognitive function and fine motor speed in older women with diabetes mellitus: results from the Women’s Health Initiative Study of Cognitive Aging. Journal of Women’s Health 2011;20(10):1435-1443. PMID: 21819251; PMCID: PMC3186442

203. Fielding RA, Rejeski WJ, Church T, Espeland MA, Guralnik JM, Gill TM, Hsu FC, Katula J, King AC, Kritchevsky SB, McDermott MM, Miller ME, Nayfield S, Newman AB, Williamson JD, Bonds D, Romashkan S, Hadley E, Pahor M for the LIFE Research Group. The Lifestyle Interventions and Independence for Elders (LIFE) Study: Design and methods. Journal of Gerontology: Medical Sciences 2011;66A(11):1226-1237. PMID: 21825283

204. Marsh AP, Rejeski WJ, Espeland MA, Miller ME, Church TS, Fielding RA, Gill TM, Guralnik JM, Newman AB, Pahor M. Muscle strength and BMI as predictors for major mobility disability in the Lifestyle Interventions and Independence for Elders Pliot. Journal of Gerontology: Medical Sciences 2011;66A(12);1376-1383. doi: 10.1093/gerona/glr158.

205. The Look AHEAD Research Group. The development and description of the comparison group in the Look AHEAD Trial. Clinical Trials 2011;8(3):320-9.

206. Gaussoin SA, Espeland MA, Absher J, Howard BV, Jones BM, Rapp SR. Ascertaining dementia related outcomes for deceased and proxy-dependent participants: an overview of WHIMS Supplemental Case Ascertainment Protocol (WHIMS-SCAP). International Journal of Geriatric Psychiatry 2012;27(2):205-214. (DOI: 10.1002/gps.2714)

207. Casanova R, Maldjian JA, Espeland MA. Evaluating the impact of different factors on voxel-wise classification methods of ADNI structural MRI brain images. International Journal of Biomedical Data Mining 2011 doi:10.4303/ijbdm/B110102 PMID 22016732

208. Haan M, Espeland MA, Klein BE, Casanova R, Gaussoin SA, Jackson RD, Millen AE, Resnick SM, Rossouw JE, Shumaker SA, Wallace R, Yaffe K. Cognitive function and retinal and ischemic brain changes: the Women’s Health Initiative. Neurology 2012;78(13):942-949. PMCID: PMC3310310

209. Bertoni AG, Wagenknecht LE, Kitzman DW, Marcovina SM, Rushing J, Espeland MA. Impact of a behavioral intervention on NT-pro brain natriuretic peptide in overweight and obese persons with diabetes from the Look AHEAD study. Obesity 2012;20:1511-1518 PMIC: 21959345.

210. Casanova R, Wagner B, Whitlow CT, Williamson JD, Shumaker SA, Maldjian JA,

Espeland MA. High dimensional classification of structural MRI Alzheimer’s disease data based on large scale regularization. Frontiers in Neuroinformatics 2011;5:22.

211. Casanova R, Whitlow C, Wagner B, Espeland MA. Combining graph and machine learning methods to analyze differences in functional connectivity across sex. The Open

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Neuroimaging Journal 2012;6:1-9. 212. Phelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, DiLillo

V, Gorin AM, West DS, Brown JS. Weight loss prevents urinary incontinence in women with type 2 diabetes: Results from the Look AHEAD trial, Journal of Urology 2012;187:939-944.

213. Mount DL, Davis C, Kennedy B, Raatz S, Dotson K, Gary-Webb T, Thomas S, Johnson

KC, Espeland MA. Factors influencing enrollment of African-Americans in the Look AHEAD Trial. Clinical Trials 2012;9:80-89. (PMID 22064686).

214. Goveas JS, Hogan PS, Kotchen JM, Smoller J, Denburg NL, Manson J, Mysiw WJ,

Ockene J, Woods N, Espeland MA, Smoller-Wassertheil S. Depressive symptoms, antidepressant use and future cognitive health in postmenopausal women: The Women’s Health Initiative Memory Study. International Psychogeriatrics 2012;24:1252-1264. PMID: 22301077.

215. Neiberg RH, Wing R, Bray GA, Reboussin DM, Rickman AD, Johnson KC, Kitabchi AE,

Faulconbridge L, Kitzman D, Espeland MA. Are different patterns of weight changes at year 1 associated with longer term weight maintenance and cardiovascular disease risk factors? Results from the intervention arm of the Action for Health in Diabetes (Look AHEAD) Study Group. Obesity 2012;13:2014-2056. PMID 22327053.

216. Woods NF, Cochrane BB, LaCroix AZ, Seguin RA, Zaslavsky O, Liu J, Beasley JM,

Brunner RL, Espeland MA, Goveas JS, Lane DS, Manson JE, Mouton CP, Robinson JG, Tinker LF. Toward a positive aging phenotype for older women: observations from the Women’s Health Initiative. Journal of Gerontology: Biological and Medical Sciences 2012;67:1191-1196. PMID 22518819.

217. Kavanagh K, Espeland MA, Sutton-Tyrrell K, Matthews KA, Barinas-Mitchell E, El Khoudary SR, Wildman RP. Liver fat and sex hormone binding globulin affect insulin resistance in midlife women: The Study of Women’s Health Across the Nation (SWAN). Obesity 2013;21:1031-1038. PMID 23784907

218. Rapp SR, Legault C, Espeland MA, Resnick SM, Hogan PE, Coker LH, Dailey M, Shumaker SA. Validation of a cognitive assessment battery administered by telephone. Journal of the American Geriatrics Society 2012;60:1616-1623. PMID 22985137

219. Pottala JV, Espeland MA, Polreis J, Robinson J, Harris WS. Correcting the effects of -20°C storage and aliquot size on erythrocyte fatty acid content in the Women’s Health Initiative. Lipids 2012;47:835-846. PMID22782370

220. Rossom RC, Espeland MA, Manson JE, Dysken MW, Johnson KC, Lane DS, LeBlanc ES, Lederle FA, Masaki K, Margolis KL. Calcium and vitamin D supplementation and cognitive impairment in the Women’s Health Initiative. Journal of the American Geriatrics Society 2012;60:197-205. PMID23176129.

221. Casanova R, Hui F-C, Espeland MA. Classification of structural MRI images in Alzheimer’s disease from the perspective of ill-posed problems. PLoS ONE 2012:7(10): e44877. doi:10.1371/journal.pone.0044877. PMID: 23071501

222. Espeland MA, Bryan RN, Goveas JS, Robinson J, Siddiqui MS, Liu S, Hogan PE, Casanova R, Coker LH, Yaffe K, Masaki K, Rossom R, Resnick SM. Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women’s Health Initiative Magnetic Resonance Imaging Studies. Diabetes Care 2013;36:90-97. PMID: 22933440.

223. Sophonsritsuk A, Appt SE, Clarkson TB, Shively CA, Espeland MA, Register TC. Differential effects of estradiol on carotid artery inflammation when administered early vs. late after surgical menopause. Menopause 2013;20:540-547. PMID 23625645

224. Rubin RR, Peyrot M, Gaussoin SA, Espeland MA, Williamson D, Faulconbridge LF,

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Wadden TA, Ewing L, Safford M, Evans-Hudnall G, Wing RR, Knowler WC. Four-year analysis of cardiovascular disease risk factors, depression symptoms and antidepressant medicine use in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss in diabetes. Diabetes Care 2013;36(5):1088-04.PMID 23359362.

225. Espeland MA, Pettinger M, Falkner KL, Shumaker SA, Limacher M, Thomas F, Weaver KE, Stefanick ML, McQuellon C, Hunt JR, Johnson KC. Demographic and health factors associated with enrollment in post-trial studies: the Women’s Health Initiative Hormone Therapy Trial. Clinical Trials 2013;10:459-468. PMID: 23480899 PMCID: PMC4102257 PMCID:PMC4102257

226. Espeland MA, Katula JA, Rushing J, Kramer AF, Jennings J, Sink KM, Nadkarni NK, Reid KF, Castro CM, Church T, Kerwin DR, Williamson JD, Marottoli RA, Rushing S, Marsiske M, Rapp SR. Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors. International Journal of Geriatric Psychiatry 2013;28:1230-1250. PMID23589390 PMC3775886

227. Kostis WJ, Cabrera J, Hooper C, Whelton PK, Espeland MA, Cosgrove NM, Cheng JQ, Deng Y, De Staercke C, Pyle M, Marathur N, Reyes I, Anderson CAM, Liu J, Kostis JB. Relationship between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension. Hypertension 2013;61:857-863.

228. Espeland MA, Rejeski WJ, West DS, Bray GA, Clark JM, Peters AL, Chen H, Johnson KC, Horton ES, Hazuda HP. Intensive weight loss intervention in individuals ages 65 years or older: Results from the Look AHEAD Trial. Journal of the American Geriatrics Society 2013:61:912-922. PMID 23668423 PMCID: PMC4123658

229. Vaughan L, Espeland MA, Snively B, Shumaker SA, Rapp S, Shupe J, Robinson J, Sarto GE, Resnick SM. The rationale, design, and baseline characteristics of the Women’s Health Initiative Memory Study of Younger Women (WHIMS). Brain Research 2013;1514:3-11. PMID 23578696.

230. Espeland MA, Shumaker SA, Leng I, Manson JE, Brown CM, LeBlanc ES, Vaughan L, Robinson J, Rapp SR, Goveas JS, Lane D, Wactawski-Wende J, Stefanick MS, Li W, Resnick SM. Long term effect on cognitive function of postmenopausal hormone therapy prescribed to women aged 50-55 years. JAMA Internal Medicine 2013;173:1429-36. PMID: 23797469.

231. Wing RR, Tate D, Espeland M, Gorin A, LaRose J, Robichaud EF, Erickson K, Perdue L, Bahnson J, Lewis CE. Weight gain prevention in young adults: design of the study of novel approaches to weight gain prevention (SNAP) randomized controlled trial. BMC Public Health 2013;13(1):300. PMID 23556505.

232. Van Dorsten JP, Dodson WC, Espeland MA, Grobman WA, Guise JM, Mercer BM, Minkoff HL, Olkkola SC, Poindexter B, Prosser LA, Sawaya GF, Scott JR, Silver RM, Smith L, Thomas A, Tita ATN. National Institutes of Health Consensus Development Conference Statement: Diagnosing Gestational Diabetes Mellitus Conference, March 4-6, 2013. NIH Consensus Statement Scientific Statement 2013;29:1-31. PMID 23748438.

233. The Look AHEAD Research Group. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. New England Journal of Medicine 2013;369:145-154. PMID: 23796131.

234. Rapp SR, Espeland MA, Manson JE, Resnick SM, Smoller S, Coker LH, Phillips LS, Stefanick ML, Sarto GE, Bryan NR. Educational attainment, MRI changes and cognitive function in older postmenopausal women from the Women’s Health Initiative Memory Study. International Journal of Psychiatry in Medicine 2013;46:121-143. PMCID: PMC4544866

235. National Institutes of Health Consensus Development Conference Statement.

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Diagnosing gestational diabetes mellitus. Obstetrics and Gynecology 2013;122:358-369. PMID 23969806

236. McDermott MM, Applegate WB, Bonds DE, Buford TW, Church T, Espeland MA, Gill TM, Guralnik JM, Haskell W, Lovato LC, Pahor M, Pepine CJ, Reid KF, Newman A. Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the Lifestyle Interventions and Independence for Elders study. Journal of the American Heart Association 2013;2:e000257 PMCID: PMC3886743

237. Amman EM, Pottala JV, Harris WS, Espeland MA, Wallace R, Denberg NL, Carnahan R, Robinson JG. Omega-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA. Neurology 2013;81:1484-91. PMID 24068783.

238. Casanova R, Hsu FC, Sink K, Rapp SR, Williamson JD, Resnick SM, Espeland MA. Alzheimer’s disease risk assessment using large-scale machine learning methods. PLoS One 2013;8:e77949. PMCID: PMC3826736

239. Coker LH, Espeland MA, Hogan PE, Resnick SM, Bryan RN, Robinson JG, Goveas JS, Davatzikos C, Kuller LH, Williamson JD, Bushnell CD, Shumaker SA. Change in brain and lesion volumes following CEE therapies: The WHIMS MRI Studies. Neurology 2014;82:427-434. PMCID: PMC3917682

240. Wing RR, Leahey T, Jeffery R, Johnson KC, Hill JO, Coday M, Espeland MA. Do weight loss and adherence cluster within behavioral treatment groups? Obesity 2014;22:638-644. PMID PMCID: PMC3859866

241. Goveas JS, Espeland MA, Hogan PE, Tindle HA, Shih RA, Kotchen JM, Robinson JG, Barnes DE, Resnick SM. Depressive symptoms and longitudinal changes in cognition: Women’s Health Initiative Study of Cognitive Aging. Journal of Geriatric Psychiatry and Neurology 2014;27:94-102. PMCID: PMC4433445

242. Espeland MA, Lewis CE, Bahnson J, Knowler WC, Regensteiner J, Gaussoin SA, Beavers D, Johnson KC. Impact of intensive lifestyle intervention on ankle-brachial index and inter-artery systolic blood pressures in a cohort of overweight and obese individuals with diabetes: Results From the Action for Health in Diabetes (Look AHEAD) Clinical Trial. Obesity 2014;22:1032-1041. PMCID: PMC3968218

243. Pottala JV, Yaffe K, Robinson J, Espeland MA, Wallace R, Harris WS. Higher RBC EPA+DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. Neurology 2014;82:435-442. PMCID: PMC3917688

244. Vaughan L, Leng I, Dagenbach D, Resnick SM, Rapp SR, Jennings JM, Brunner RL,

Simpson SL, Beavers D, Coker LH, Gaussoin SA, Sink K, Espeland MA. Intra-individual variability in domain-specific cognitive function and risk of MCI and dementia. Current Gerontology and Geriatrics Research 2013 doi:10.1155/2013/495793 PMCID: PMC3881440

245. Persons JE, Robinson JG, Ammann EM, Coryell WH, Espeland MA, Harris WS, Manson JE, Fiedorowicz JG. Omega-3 fatty acid biomarkers and depressive symptoms. International Journal of Geriatric Psychiatry 2014:82:427-434. PMCID: PMC4048630

246. Klepin HC, Geiger AM, Bandos H, Constantino JP, Rapp S, Sink KM, Lawrence JA,

Atkinson HH, Espeland MA. Cognitive factors associated with adherence to oral anti-estrogen therapy: Results from the Cognition in the Study of Tamoxifen and Raloxifene (CoSTAR) study. Cancer Prevention Research 2014;7:161-8. PMCID: PMC3924583

247. Espeland MA, Rapp SR. Bray GA, Houston DK, Johnson KC, Kitabchi AE, Hergenroeder AL, Williamson J, Jakicic JM, Van Dorsten B, Williamson J, Kritchevsky SB. Long-term impact of behavioral weight loss intervention on cognitive function: The Action for Health in Diabetes Movement and Memory Study. Journal of Gerontology:

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Medical Sciences 2014;69;1101-8. PMCID: PMC4158413

248. Pottala JV, Djira GD, Espeland MA, Ye J, Larson MG, Harris WS. Structural equation modelling for analyzing erythrocyte fatty acids in Framingham. Computational and Mathematical Methods in Medicine 2014;82:435-442. PMCID: PMC4052884

249. Espeland MA, Glick HA, Bertoni AL, Brancati FL, Bray GA, Clark JM, et al. Impact of an intensive lifestyle intervention on use and costs of medical services among overweight and obese adults with type 2 diabetes: The Action for Health in Diabetes. Diabetes Care, 2014;37:2548-2556. PMCID: PMC4140155

250. Davenport EM, Whitlow CT, Urban JE, Espeland MA, Jung Y, Powers AK, Stitzel JD, Maldjian JA. Abnormal white matter integrity related to head impact exposure in a season of high school varsity football. Journal of Neurotrauma 2014;31:1617-1624. PMCID: PMC4170811

251. Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD for the LIFE study investigators. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE Study randomized clinical trial. JAMA 2014;311:2387-96. PMCID: PMC4266388

252. Sink KM, Espeland MA, Rushing J, Castro CM, Church T, Cohen R, Gill TM, Henkin L, Jennings JM, Kerwin D, Manini T, Myers V, Pahor M, Reid KF, Woolard N, Rapp S, Williamson J for the LIFE Investigators. The LIFE Cognition Study: design and baseline characteristics. Clinical Interventions in Aging 2014;9:1-12. PMCID: PMC4154884

253. Vaughan L, Erickson KE, Espeland MA, Smith JC, Tindle H, Rapp SR. Concurrent and longitudinal relationships between cognitive activity engagement, cognitive performance, and brain volume in older adult women. Journal of Gerontology: Psychological Sciences 2014;69:826-836. PMCID: PMC429614

254. Tate DF, LaRose JG, Griffin LP, Erickson KE, Ferguson E, Perdue L, Espeland M, Wing RR. Recruitment of young adults into a randomized controlled trial of weight gain prevention: message development, methods, and cost. Trials 2014;15:326. PMCID: PMC4150977

255. Espeland MA, Beavers KM, Gibbs BB, Johnson KC, Hughes TM, Baker LD, Jakicic J, Korytkowski M, Miller M, Bray GA. Ankle-brachial index and inter-artery blood pressure differences as predictors of cognitive function in overweight and obese older adults with diabetes: Results from the Action for Health in Diabetes Movement and Memory Study. International Journal of Geriatric Psychiatry 2015;30:999-1007. PMID 25546023

256. Marx N, Rosenstock J, Kahn SE, Zinman B, Kastelein JJ, Lachin J, Espeland MA, Bluhmki E, Mattheus M, Ryckaert B, Patel S, Johansen OE, Woerle H-J. Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes: CAROLINA®. Diabetes and Vascular Disease Research 2015:12:164-74. PMCID: PMC4390606

257. Espeland MA, Probstfield J, Hire D, Redmon JB, Evans GW, Coday M, Lewis CE, Johnson KC, Wilmoth S, Bahnson J, Dulin MF, Green JB, Knowler WC, Kitabchi A, Murillo AL, Osei K, Rehman SU, Cushman WC and the Look AHEAD Research Group; and the ACCORD Study Group. Systolic blood pressure control among individuals with type 2 diabetes: a comparative effectiveness analysis of three interventions. American Journal of Hypertension 2015;28:995-1009. PMCID: PMC4506323

258. Wing RR, Tate D, LaRose JG, Gorin A, Erickson K, Robichaud EF, Perdue L, Bahnson

J, Espeland MA. Frequent self-weighing as part of a constellation of healthy weight control practices in young adults. Obesity 2015;23:943-59. PMCID: PMC4438264

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259. Espeland MA, Newman AB, Sink K, Gill TM, King AC, Miller ME, Guralnik J, Katula J, Church T, Manini T, Reid KF, McDermott MM. Associations between ankle-brachial index and cognitive function: Results from the Lifestyle Interventions and Independence for Elders Trial. Journal of the American Medical Directors Association 2015;16:682-689. PMCID: PMC4516564

260. Neiberg RH, Rejeski JJ, Applegate WB, Clark JM, Knowler WC, Bray GA, Espeland MA, Cheskin LJ. Self-reported gastrointestinal symptoms in type 2 diabetes improve with an intensive lifestyle intervention. Clinical Diabetes 2015;33:181-8. PMID 26487792.

261. Espeland MA, Brinton RD, Manson JE, Yaffe K, Hugenschmidt C, Vaughan L, Craft S, Edwards BJ, Casanova R, Masaki K, Resnick SR. Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes. Neurology 2015;85:13:1131-1138. PMCID: PMC4603880

262. Chen JC, Wang X, Wellenius GA, Serre ML, Driscoll I, Casanova R, McArdle JJ, Manson

JE, Chui HC, Espeland MA. Ambient air pollution and neurotoxicity on brain structure. Annals of Neurology 2015;78:466-476. PMCID: PMC4546504

263. Sink K, Espeland MA, Castro C, Church T, Cohen R, Dodson JA, Guralnik J, Hendrie HC, Jennings J, Katula J, Lopez OL, McDermott M, Pahor M, Reid KF, Rushing J, Verghese J, Rapp S, Williamson J, for the LIFE Study investigators. Effect of physical activity on cognitive outcomes in sedentary older adults. Results from the LIFE Randomized Clinical Trial. JAMA 2015;314:781-790. PMID: 26305648 PMCID: PMC4698980

264. Espeland MA, Brinton RD, Hugenschmidt C, Manson JE, Craft S, Yaffe K, Weitlauf J, Vaughan L, Johnson KC, Padula CB, Jackson R, Resnick SM for the WHIMS Study Group. Impact of type 2 diabetes mellitus and postmenopausal hormone therapy on incidence of cognitive impairment in older women. Diabetes Care 2015;38:2316-24. PMID 26486190. PMCID: PMC4657616

265. Vaughan L, Bushnell C, Bell CL, Espeland MA. Global cognitive function before, surrounding, and after ischemic stroke: the role of risk and protective factors varies with time among ischemic stroke survivors. Aging, Neuropsychology and Cognition 2016;23:117-131. PMID: 26073439. PMCID: PMC4916645

266. Chen JC, Espeland MA, Brunner RL, Lovato LC, Wallace RB, Leng X, Phillips LS, Robinson JG, Kotchen JM, Johnson KC, Manson JE, Stefanick ML, Sarto GE, Mysiw WJ. Sleep duration, cognitive decline, and dementia risk in older women. Alzheimer’s and Dementia 2016;12:21-33. PMID: 26086180

267. Padula CB, Weitlauf JC, Rosen AC ,Reiber G, Naughton M, Rissling M, Hunt J, Li W,

Cochrane B, Goldstein M, Yaffe K, Espeland MA. Longitudinal cognitive trajectories of women veterans from the Women’s Health Initiative Memory Study. The Gerontologist 2016;56:115-25. doi: 10.1093/gerona/glv050 PMID: 26615021

268. Groessl EJ, Kaplan RM, Sweet CMC, Church T, Espeland MA, Gill TM, Glynn NW, King AC, Kritchevsky S, Manini T, McDermott M, Reid K, Rushing J, Pahor M. Cost-effectiveness of the LIFE physical activity intervention for older adults at increased risk for mobility disability. Journal of Gerontology Medical Sciences 2016;71:656-662. EPub PMID: 26888433

269. Driscoll I, Gaussoin S, Wassertheil-Smoller S, Limacher M, Casanova R, Yaffe K,

Resnick S, Espeland MA. Obesity and brain structural integrity in older women: the Women's Health Initiative Magnetic Resonance Imaging Study (WHIMS-MRI). Journal of Gerontology Medical Sciences 2016 Dec;71(12):1596-1602 26961581 PMCID: PMC4978361

270. Harris WS, Luo J, Pottala JV, Margolis K, Espeland MA, Robinson JG. Red blood cell

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fatty acids and incident diabetes mellitus in the Women's Health Initiative Memory Study. PLoS One 2016:11(2): e0147894. doi:10.1371/journal.pone.0147894. PMID: 26881936

271. Wing RR, Tate DF, Espeland MA, Lewis CE, LaRose JG, Gorin AA, Bahnson J, Perdue LH, Hatley KE, Ferguson E, Garcia KR, Lang W for the Study of Novel Approaches to Weight Gain Prevention (SNAP) Research Group. Innovative self-regulation strategies reduce weight gain in young adults: The Study of Novel Approaches to Weight Gain Prevention (SNAP) Randomized Controlled Trial JAMA Internal Medicine 2016;16;755-762. PMID: 27136493

272. Espeland MA, Erickson K, Neiberg RH, Jakicic JM, Wadden TA, Wing RR, Desiderio L, Erus G, Hsieh M-K, Davatzikos C, Maschak-Carey BJ, Laurienti PJ, Demos-McDermott K, Bryan RN for the Action for Health In Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) Ancillary Study Research Group. Brain and white matter hyperintensity volumes after ten years of random assignment to lifestyle intervention. Diabetes Care 2016;39(5):764-771. PMCID: PMC4839171

273. Goveas JS, Rapp SR, Hogan PE, Driscoll I, Tindle HA, Smith JC, Kesler SR, Zaslavsky

O, Rossom RC, Ockene JK, Yaffe K, Manson JE, Resnick SM, Espeland MA. Predictors of optimal cognitive aging in 80+ women: The Women’s Health Initiative Memory Study. Journal of Gerontology A Biological Sciences Medical Sciences 2016;71:S62-71. PMCID: PMC4759985

274. Beavers DP, Pettinger M, Espeland MA, Snively BM, Leng X, Hunt JR, Tindle HA, Shumaker SA. The evolution of the WHI 80+ cohort. Journal of Gerontology A Biological Sciences Medical Sciences 201671:S13-22.

275. Zhang T, Casanova R, Resnick SM, Manson JE, Baker LD, Padua CD, Kuller LH, Bryan

N, Espeland MA, Davatzikos C. Effects of hormone therapy on brain volumes changes of postmenopausal women revealed by optimally-discriminative voxel-based morphometry. PLoS One 2016 Mar 14;11(3):e0150834. PMID: 26974440.

276. Zhang, P, Hire D, Espeland MA, Knowler WC, Thomas S, Tsai AD, Glick HA, Impact of Intensive Lifestyle intervention on preference-based quality of life in type 2 diabetes: results from the Look AHEAD Trial. Obesity 2016;24:856-864. PMID 2708282 PMCID: PMC4817364

277. Davenport EM, Apkarian K, Whitlow CT, Urban JE, Jensen JH, Szuch E, Espeland MA, Jung J, Rosenbaum DA, Gioia GA, Powers AK, Stitzel JD, Maldjian JA. Abnormalities in diffusional kurtosis metrics related to head impact exposure in a season of high school varsity football. Journal of Neurotrauma 2016;33:2133-2146. PMCID: PMC5124736

278. Driscoll I, Shumaker SA, Snively BM, Margolis K, Manson JE, Ockene J, Vitolins MZ,

Rossom RC, Espeland MA. Relationships between caffeine intake and risk for probable dementia or global cognitive impairment: The Women¹s Health Initiative Memory Study (WHIMS). Journal of Gerontology A Biological Sciences Medical Sciences 2016;71:596-1602.PMID: 26961581 PMCID: PMC5106861

279. Crane MM, LaRose JG, Espeland MA, Wing RR, Tate DF. Recruitment of young adults for weight gain prevention: randomized comparison of direct mail strategies. Trials 2016;17(1);282. PMCID: PMC4897900

280. The Look AHEAD Study Group. Association of the magnitude of weight loss and physical fitness change on long-term CVD outcomes: The Look AHEAD Study. Lancet Diabetes and Endocrinology 2016;4(11):913-921. PMCID: PMC5094846

281. Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA. Metformin as a tool targeting aging. Cell Metabolism 2016;23(6):1060-5 (Online). PMID 27304507

282. Espeland MA, Rapp SR, Manson JE, Goveas JS, Shumaker SA, Hayden K, Weitlauf J, Gaussoin SA, Baker LD, Padula CB, Hou L, Resnick SR. Long term effects on cognitive

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trajectories of postmenopausal hormone therapy in two age groups. Journal of Gerontology A Biological Sciences Medical Sciences 2017;72:838-845. PMID: 27506836

283. Espeland MA, Lipska K, Miller ME, Rushing J, Cohen RA, Verghese J, McDermott MM, King AC, Strotmeyer ES, Blair SN, Pahor M, Reid K, Demons J, Kritchevsky SB. Effects of physical activity intervention on physical and cognitive function in older, sedentary adults with and without diabetes. Journal of Gerontology A Biological Sciences Medical Sciences 2017;72:861-866. PMID: 27590629.

284. Rapp SR, Luchsinger JA, Baker LD, Blackburn GL, Hazuda HP, Demos-McDermott KE, Jeffery RW, Keller JN, McCaffery JM, Pajewski NM, Evans M, Wadden TA, Arnold SE,

Espeland MA for the Look AHEAD Research Group. Effect of a long-term intensive lifestyle intervention on cognitive function: Action for Health in Diabetes Study. Journal of the American Geriatrics Society 2017 EPub.PMID: 28067945

285. de Filippi CR, de Lemos JA, Newman AB, Guralnik JM, Christenson RH, Pahor M,

Church T, Espeland M, Kritchevsky SB, Stafford R, Seliger SL. Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: Results from a randomized pilot study of exercise intervention. American Heart Journal 2016;179:151-6.

286. Casanova R, Wang X, Reyes J, Akita Y, Serre ML, Vizuete W, Chui HC, Driscoll I,

Resnick SM, Espeland MA, Chen JC. A voxel-based morphometry study reveals local brain structural alterations associated with ambient fine particles in older women. Frontiers in Human Neuroscience 2016;10.495.DOI: 10.3389/fnhum.2016.00495

287. Casanova R, Hayasaka S, Santiago Saldana, Bryan RN, Demos KE, Desiderio L,

Erickson KI, Espeland MA, Nasrallah IM, Wadden T, Laurienti P for the Action for Health in Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) Ancillary Study Research Group. Relative differences in resting-state brain connectivity associated with long term intensive lifestyle intervention. Psychoneuroendocrinology 2016;74:231-239. PMID: 27685338 PMCID: PMC5159283

288. Snyder HM, Asthana S, Bain L, Brinton R, Craft S, Dubal DB, Espeland MA, Gatz M, Mielke MM, Raber J, Rapp PR, Yaffe K, Carrillo MC. Sex biology contributions to vulnerability to Alzheimer’s disease: a think tank convened by the Women’s Alzheimer’s Research Initiative. Alzheimer’s & Dementia 2016;12:1186-1196. PMID: 27692800

289. Rushing J, Wing R, Wadden TA, Knowler WC, Lawlor M, Evans M, Killean T, Montez M,

Espeland MA, Zhang P for the Look AHEAD Research Group. Cost of intervention delivery in a lifestyle weight-loss trial in type 2 diabetes: results from the Look AHEAD clinical trial. Obesity Science & Practice 2017;3:15-24. PMCID: PMC5358076

290. Espeland MA, Crimmins EM Grossardt B, Crandall JP, Gelfond JAL, Harris TB, Kritchevsky S, Manson JE, Robinson JG, Rocca WA, Temprosa M, Thomas F, Wallace R, Barzilai N for the Multimorbidity Clinical Trials Consortium. Clinical trials targeting aging and age-related multimorbidity. Journal of Gerontology A Biological Sciences Medical Sciences 2017;72:355-361. doi:10.10.1093/Gerona/glw220

291. Cacciottolo M, Wang X, Driscoll I, Woodward N, Saffari A, Reyes J, Serre ML, Vizuete

W, Sioutas C, Morgan TE, Gatz M, Chui HC, Shumaker SA, Resnick SM, Espeland MA, Finch CE, Chen JC. Particulate air pollutants, APOE alleles, and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models. Translational Psychiatry 2017;7;e1022;doi:10;1038/tp.2016.289. PMCID: PMC5299391

292. Unick J, Lang W, Tate DF, Bond DS, Espeland MA, Wing RR. Objective estimates of physical activity and sedentary time among young adults. Journal of Obesity. Epub 2017, Article ID 9257564, https://doi.org/10.1155/2017/9257564

293. Harris WS, Luo J, Pottala JV, Espeland MA, Margolis KL, Manson JE, Wang, Brasky

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TM, Robinson JG. Red blood cell polyunsaturated fatty acids and mortality in the Women’s Health Initiative Memory Study. Journal of Clinical Lipidology 2016;11:250-259. PMID: 28391893

294. Espeland MA, Luchsinger JA, Baker LD, Neiberg R, Kahn SE, Arnold SE, Wing RR, Blackburn GL, Bray G, Evans M, Hazuda HP, Jeffery RW, Wilson VM, Clark JM, Coday M, Demos-McDermott K, Foreyt JP, Greenway F, Hill JO, Horton ES, Jakicic JM, Johnson KC, Knowler WC, Lewis CE, Nathan DM, Peters A, Pi-Sunyer X, Pownall H, Wadden TA, Rapp SR for the Look AHEAD Study Group. Effect of a long-term intensive lifestyle intervention on prevalence of cognitive impairment. Neurology 2017;88:2026-2035. PMID: 28446656 PMCID: PMC5440245

295. Kelley ME, Urban JE, Miller LE, Jones DA, Espeland MA, Davenport EM, Whitlow CT, Maldjian JA, Stitzel JD. Head impact exposure in youth football: comparison among age and weight based levels of play. Journal of Neurotrauma 2017;34:1939-1947. PMID: 28274184

296. Hughes TM, Craft S, Baker LD, Espeland MA, Rapp S, Sink KM, Bertoni A, Burke GL, Gottesman R, Michos E, Luchsinger JA, Fitzpatrick AL, Hayden KM. Changes in metabolic risk factors over 10 years and their associations with late-life cognitive performance: The Multi-Ethnic Study of Atherosclerosis (MESA). Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2017;8:18-25. PMCID: PMC5390661

297. Manini TM, Anton SD, Beavers DP, Cauley J, Espeland MA, Fielding RA, Kritchevsky SB, Leeuwenburgh C, Lewis KH, Liu CK, McDermott MM, Miller ME, Tracy RP, Walston J, Radziszewsk B, Lu J, Stowe C, Wu S, Newman A, Ambrosius WT, Pahor M. For the ENRGISE Pilot study investigators. ENabling Reduction of low-Grade Inflammation in Seniors (ENRGISE) Pilot study: Concept, rationale and design. Journal of the American Geriatrics Society 2017;65:1961-1968. PMID 28734043.

298. Kelley M, Kane J, Espeland MA, Miller LE, Powers AK, Stitzel JD, Urban JE. Practice drill head impact exposure measured from a single youth football team. Journal of Neurosurgery: Pediatrics. 2017 EPub PMID 28937917..

299. Wing RR, Tate DF, Garcia KR, Bahnson J, Lewis CE, Espeland MA for the Study of Novel Approaches to Weight Gain Prevention (SNAP) Research Group. Improvements in cardiovascular risk factors in young adults in a randomized trial of approaches to weight gain prevention. Obesity 2017;25:1660-1666. PMID: 28782918

300. Holcombe A, Ammann E, Espeland MA, Kelley BJ, Manson JE, Wallace R, Robinson J. Chronic use of aspirin and total white matter lesion volume: Results from the Women's Health Initiative Memory Study of Magnetic Resonance Imaging Study. Journal of Stroke and Cerebrovascular Diseases 2017;26:2128-2136. EPub PMID: PMID: 28551293

301. Leng X, Espeland MA, Manson JE, Stefanick ML, Gower EW, Hayden KM, Limacher MC; Vaughan L, Robinson J, Wallace R, Wassertheil-Smoller S, Yaffe K, Shumaker SA. Cognitive function and changes in cognitive function as predictors of incident cardiovascular disease: The Women’s Health Initiative Memory Study (WHIMS). Journal of Gerontology: Medical Sciences 2017 EPub PMID: 28977360.

302. Ammann EM, Pottala JV, Robinson JG, Espeland MA, Harris WS. Erythrocyte omega-3 fatty acids are inversely associated with incident dementia: Secondary analyses of longitudinal data from the Women's Health Initiative Memory Study (WHIMS). Prostaglandins Leukot Essent Fatty Acids 2017;121:68-75. PMID: 28651700 PMCID: PMC5564209

303. Espeland MA, Carmichael O, Hayden K, Neiberg RH, Newman AB, Keller JN, Wadden TA, Rapp SR, Hill JO, Horton ES, Johnson KC, Wagenknecht L, Wing RR. Long-term

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impact of weight loss intervention on changes in cognitive function: exploratory analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. Journal of Gerontology: Medical Sciences 2017 EPub PMID 28958022.

304. Korthauer LE, Goveas JS, Espeland MA, Shumaker SA, Garcia KR, Ockene J, Tindle H, Salmoirago-Blotcher E, Cochrane B, Sink KM, Vaughan L, Rapp S, Resnick SM, Driscoll, I. Negative affect is associated with increased incidence of mild cognitive impairment in nondepressed postmenopausal women. Journal of Gerontology: Medical Sciences 2017 EPub PMID 29028908.

305. Manson JE, Aragaki AK, Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Chlebowski RT, Howard BV, Thomson CA, Margolis KL, Lewis CE, Stefanick ML,

Jackson RD, Johnson KC, Martin LW, Shumaker SA, Espeland MA, Wactawski-Wende J; for the WHI Investigators. Menopausal hormone therapy and long-term all-cause and cause-specific mortality: The Women’s Health Initiative randomized trials. JAMA 2017;318(10):927-938.

306. Espeland MA, Luchsinger JA, Neiberg RH, Carmichael O, Laurienti PJ, Pi-Sunyer X, Wing RR, Cook D, Horton E, Casanova R, Erickson K, Bryan RN for the Action for Health in Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) Research Group. Long term impact of intensive lifestyle intervention on cerebral blood flow. Journal of the American Geriatrics Society, 2017 (in press).

307. Biessels GJ, Janssen J, van den Berg E, Zinman B, Espeland MA, Mattheus M, Johansen OE. Rationale and design of the CAROLINA® - cognition sub-study: a randomised controlled trial on cognitive outcomes of linagliptin versus glimepiride in patients with type 2 diabetes mellitus. BMC Neurology 2017, in press).

Consortium Publications Appearing On PubMed Listing Authorship for Me

1. Rejeski WJ, King AC, Katula JA, Kritchevsky S, Miller ME, Walkup MP, Glynn NW, Pahor M; LIFE Investigators. Physical activity in prefrail older adults: confidence and satisfaction related to physical function. Journal of Gerontology Psychological Sciences Social Sciences 2008;63(1):P19-26.PMID: 18332190

2. Chlebowski RT, Johnson KC, Kooperberg C, Pettinger M, Wactawski-Wende J, Rohan T, Rossouw J, Lane D, O'Sullivan MJ, Yasmeen S, Hiatt RA, Shikany JM, Vitolins M, Khandekar J, Hubbell FA; Women's Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of breast cancer. Journal of the National Cancer Institute 2008;100:1581-91. PMID: 19001601

3. Tinker LF, Bonds DE, Margolis KL, Manson JE, Howard BV, Larson J, Perri MG, Beresford SA, Robinson JG, Rodríguez B, Safford MM, Wenger NK, Stevens VJ, Parker LM; Women's Health Initiative. Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trial. Archives of Internal Medicine 2008;168:1500-11. PMID: 18663162

4. Wadden TA, West DS, Neiberg RH, Wing RR, Ryan DH, Johnson KC, Foreyt JP, Hill JO, Trence DL, Vitolins MZ; Look AHEAD Research Group. One-year weight losses in the Look AHEAD study: factors associated with success. Obesity (Silver Spring) 2009;17:713-22. PMID: 19180071

5. Williamson DA, Rejeski J, Lang W, Van Dorsten B, Fabricatore AN, Toledo K; Look AHEAD Research Group. Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes. Archives of Internal Medicine 2009;169:163-71. PMID: 19171813

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6. Chlebowski RT, Kuller LH, Prentice RL, Stefanick ML, Manson JE, Gass M, Aragaki AK, Ockene JK, Lane DS, Sarto GE, Rajkovic A, Schenken R, Hendrix SL, Ravdin PM, Rohan TE, Yasmeen S, Anderson G; WHI Investigators. Breast cancer after use of estrogen plus progestin in postmenopausal women. New England Journal of Medicine 2009;360(6):573-87. PMID: 19196674

7. HEALTHY Study Group, Hirst K, Baranowski T, DeBar L, Foster GD, Kaufman F, Kennel P, Linder B, Schneider M, Venditti EM, Yin Z. HEALTHY study rationale, design and methods: moderating risk of type 2 diabetes in multi-ethnic middle school students. International Journal of Obesity (London) 2009;33 Suppl 4:S4-20. PMID: 19623188

8. McMurray RG, Bassin S, Jago R, Bruecker S, Moe EL, Murray T, Mazzuto SL, Volpe SL; HEALTHY Study Group. Rationale, design and methods of the HEALTHY study physical education intervention component. International Journal of Obesity (London) 2009;33 Suppl 4:S37-43. PMID: 19623187

9. Gillis B, Mobley C, Stadler DD, Hartstein J, Virus A, Volpe SL, El ghormli L, Staten MA, Bridgman J, McCormick S; HEALTHY Study Group. Rationale, design and methods of the HEALTHY study nutrition intervention component. International Journal of Obesity (London) 2009;33 Suppl 4:S29-36. PMID: 19623185

10. Drews KL, Harrell JS, Thompson D, Mazzuto SL, Ford EG, Carter M, Ford DA, Yin Z, Jessup AN, Roullet JB; HEALTHY Study Group. Recruitment and retention strategies and methods in the HEALTHY study. International Journal of Obesity (London) 2009;33 Suppl 4:S21-8. PMID: 19623184

11. Venditti EM, Elliot DL, Faith MS, Firrell LS, Giles CM, Goldberg L, Marcus MD, Schneider M, Solomon S, Thompson D, Yin Z; HEALTHY Study Group. Rationale, design and methods of the HEALTHY study behavior intervention component. International Journal of Obesity (London) 2009;33 Suppl 4:S44-51. PMID: 19623189

12. DeBar LL, Schneider M, Ford EG, Hernandez AE, Showell B, Drews KL, Moe EL, Gillis B, Jessup AN, Stadler DD, White M; HEALTHY Study Group. Social marketing-based communications to integrate and support the HEALTHY study intervention. International Journal of Obesity (London) 2009 Aug;33 Suppl 4:S52-9. PMID: 19623190

13. Schneider M, Hall WJ, Hernandez AE, Hindes K, Montez G, Pham T, Rosen L, Sleigh A, Thompson D, Volpe SL, Zeveloff A, Steckler A; HEALTHY Study Group. Rationale, design and methods for process evaluation in the HEALTHY study. International Journal of Obesity (London) 2009;33 Suppl 4:S60-7. PMID: 19623191

14. Vitolins MZ, Anderson AM, Delahanty L, Raynor H, Miller GD, Mobley C, Reeves R, Yamamoto M, Champagne C, Wing RR, Mayer-Davis E; Look AHEAD Research Group. Action for Health in Diabetes (Look AHEAD) trial: baseline evaluation of selected nutrients and food group intake. Journal of the American Dietetics Association 2009;109:1367-75. PMID: 19631042

15. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group, Nathan DM, Zinman B, Cleary PA, Backlund JY, Genuth S, Miller R, Orchard TJ. Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005). Archives of Internal Medicine 2009;169:1307-16. PMID: 19636033

16. Manini TM, Newman AB, Fielding R, Blair SN, Perri MG, Anton SD, Goodpaster BC, Katula JA, Rejeski WJ, Kritchevsky SB, Hsu FC, Pahor M, King AC; LIFE Research Group. Effects of exercise on mobility in obese and nonobese older adults. Obesity (Silver Spring) 2011;19:1106. PMID: 19834467

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17. Gary-Webb TL, Baptiste-Roberts K, Pham L, Wesche-Thobaben J, Patricio J, Pi-Sunyer FX, Brown AF, Jones L, Brancati FL; Look AHEAD Research Group. Neighborhood and weight-related health behaviors in the Look AHEAD (Action for Health in Diabetes) study. BMC Public Health 2010;10:312. PMID: 20525373

18. Foy CG, Lewis CE, Hairston KG, Miller GD, Lang W, Jakicic JM, Rejeski WJ, Ribisl PM, Walkup MP, Wagenknecht LE; Look AHEAD Research Group Intensive lifestyle intervention improves physical function among obese adults with knee pain: findings from the Look AHEAD trial. Obesity (Silver Spring) 2011;19:83-93. PMID: 20559303

19. HEALTHY Study Group, Foster GD, Linder B, Baranowski T, Cooper DM, Goldberg L, Harrell JS, Kaufman F, Marcus MD, Treviño RP, Hirst K. A school-based intervention for diabetes risk reduction. New England Journal of Medicine.2010;363:443-53. PMID: 20581420

20. Rochon J, Bales CW, Ravussin E, Redman LM, Holloszy JO, Racette SB, Roberts SB, Das SK, Romashkan S, Galan KM, Hadley EC, Kraus WE; CALERIE Study Group. Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy. Journal of Gerontology Medical Sciences. 2011;66:97-108. PMID: 20923909

21. Chlebowski RT, Anderson GL, Gass M, Lane DS, Aragaki AK, Kuller LH, Manson JE, Stefanick ML, Ockene J, Sarto GE, Johnson KC, Wactawski-Wende J, Ravdin PM, Schenken R, Hendrix SL, Rajkovic A, Rohan TE, Yasmeen S, Prentice RL; WHI Investigators. Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA 2010;304:1684-92. PMID: 20959578

22. de Boer IH, Rue TC, Cleary PA, Lachin JM, Molitch ME, Steffes MW, Sun W, Zinman B, Brunzell JD; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group, White NH, Danis RP, Davis MD, Hainsworth D, Hubbard LD, Nathan DM. Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort. Archives of Internal Medicine 2011;171:412-20. PMID: 21403038

23. LaCroix AZ, Chlebowski RT, Manson JE, Aragaki AK, Johnson KC, Martin L, Margolis KL, Stefanick ML, Brzyski R, Curb JD, Howard BV, Lewis CE, Wactawski-Wende J; WHI Investigators. Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial. JAMA 2011;305:1305-14. PMID: 21467283

24. Wadden TA, Neiberg RH, Wing RR, Clark JM, Delahanty LM, Hill JO, Krakoff J, Otto A, Ryan DH, Vitolins MZ; Look AHEAD Research Group. Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity (Silver Spring) 2011;19:1987-98. PMID: 21779086

25. Unick JL, Beavers D, Jakicic JM, Kitabchi AE, Knowler WC, Wadden TA, Wing RR; Look AHEAD Research Group. Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes: results from the Look AHEAD trial. Diabetes Care 2011;34:2152-7. PMID: 21836103

26. Faulconbridge LF, Wadden TA, Rubin RR, Wing RR, Walkup MP, Fabricatore AN, Coday M, Van Dorsten B, Mount DL, Ewing LJ; Look AHEAD Research Group. One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the Look AHEAD study. Obesity (Silver Spring) 2012;20:783-93. PMID: 22016099

27. DCCT/EDIC Research Group, de Boer IH, Sun W, Cleary PA, Lachin JM, Molitch ME, Steffes MW, Zinman B. Intensive diabetes therapy and glomerular filtration rate in type 1

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diabetes. New England Journal of Medicine 2011;365:2366-76. PMID: 22077236 28. Gary-Webb TL, Baptiste-Roberts K, Pham L, Wesche-Thobaben J, Patricio J, Pi-Sunyer

FX, Brown AF, Jones-Corneille L, Brancati FL; Look AHEAD Research Group. Neighborhood socioeconomic status, depression, and health status in the Look AHEAD (Action for Health in Diabetes) study. BMC Public Health 2011;11:349. PMID: 22182286

29. Peter I, McCaffery JM, Kelley-Hedgepeth A, Hakonarson H, Reis S, Wagenknecht LE, Kopin AS, Huggins GS; Genetics Subgroup of the Look AHEAD Study. Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial. Obesity (Silver Spring) 2012;20:1675-82. PMID: 22307069

30. Brancati FL, Evans M, Furberg CD, Geller N, Haffner S, Kahn SE, Kaufmann PG, Lewis CE, Nathan DM, Pitt B, Safford MM; Look AHEAD Study Group. Midcourse correction to a clinical trial when the event rate is underestimated: the Look AHEAD (Action for Health in Diabetes) Study. Clinical Trials 2012;9:113-24. PMID: 22334468

31. Schwartz AV, Johnson KC, Kahn SE, Shepherd JA, Nevitt MC, Peters AL, Walkup MP, Hodges A, Williams CC, Bray GA; Look AHEAD Research Group. Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: results from the Look AHEAD randomized trial. Journal of Bone Mineral Research 2012;27:619-27. PMID: 22354851

32. Rejeski WJ, Ip EH, Bertoni AG, Bray GA, Evans G, Gregg EW, Zhang Q; Look AHEAD Research Group. Lifestyle change and mobility in obese adults with type 2 diabetes. New England Journal of Medicine 2012;366:1209-17. PMID: 22455415

33. Lopes-Virella MF, Baker NL, Hunt KJ, Lyons TJ, Jenkins AJ, Virella G; DCCT/EDIC Study Group. High concentrations of AGE-LDL and oxidized LDL in circulating immune complexes are associated with progression of retinopathy in type 1 diabetes. Diabetes Care 2012;35:1333-40. PMID: 22511260

34. McCaffery JM, Papandonatos GD, Peter I, Huggins GS, Raynor HA, Delahanty LM, Cheskin LJ, Balasubramanyam A, Wagenknecht LE, Wing RR; Genetic Subgroup of Look AHEAD; Look AHEAD Research Group. Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. American Journal of Clinical Nutrition 2012;95:1477-86. PMID: 22513296

35. Belalcazar LM, Lang W, Haffner SM, Hoogeveen RC, Pi-Sunyer FX, Schwenke DC, Balasubramanyam A, Tracy RP, Kriska AP, Ballantyne CM; Look AHEAD Research Group. Adiponectin and the mediation of HDL-cholesterol change with improved lifestyle: the Look AHEAD Study. Journal of Lipid Research 2012;53:2726-33. PMID: 22956782

36. Ribisl PM, Gaussoin SA, Lang W, Bahnson J, Connelly SA, Horton ES, Jakicic JM, Killean T, Kitzman DW, Knowler WC, Stewart KJ; Look AHEAD Research Group. Lifestyle intervention improves heart rate recovery from exercise in adults with type 2 diabetes: results from the Look AHEAD study. Journal of Obesity 2012:309196. doi: 10.1155/2012/309196. Epub 2012 Nov 22. PMID: 23227314

37. Unick JL, Beavers D, Bond DS, Clark JM, Jakicic JM, Kitabchi AE, Knowler WC, Wadden TA, Wagenknecht LE, Wing RR; Look AHEAD Research Group. The long-term effectiveness of a lifestyle intervention in severely obese individuals. American Journal of Medicine 2013;126:236-42, 242. PMID: 23410564

38. Lopes-Virella MF, Baker NL, Hunt KJ, Cleary PA, Klein R, Virella G; DCCT/EDIC Research Group. Baseline markers of inflammation are associated with progression to macroalbuminuria in type 1 diabetic subjects. Diabetes Care 2013;36:2317-23. PMID: 23514730

39. Orchard TJ, Lyons TJ, Cleary PA, Braffett BH, Maynard J, Cowie C, Gubitosi-Klug RA,

29

Way J, Anderson K, Barnie A, Villavicencio S; DCCT/EDIC Research Group. The association of skin intrinsic fluorescence with type 1 diabetes complications in the DCCT/EDIC study. Diabetes Care 2013;36:3146-53. PMID: 23813757

40. Jacobson AM, Braffett BH, Cleary PA, Gubitosi-Klug RA, Larkin ME; DCCT/EDIC Research Group. The long-term effects of type 1 diabetes treatment and complications on health-related quality of life: a 23-year follow-up of the Diabetes Control and Complications/Epidemiology of Diabetes Interventions and Complications cohort. Diabetes Care 2013;36(10):3131-8. PMID: 23835693

41. Rejeski WJ, Axtell R, Fielding R, Katula J, King AC, Manini TM, Marsh AP, Pahor M, Rego A, Tudor-Locke C, Newman M, Walkup MP, Miller ME; LIFE Study Investigator Group. Promoting physical activity for elders with compromised function: the lifestyle interventions and independence for elders (LIFE) study physical activity intervention. Clinical Interventions for Aging 2013;8:1119-31. PMID: 24049442

42. McCaffery JM, Papandonatos GD, Huggins GS, Peter I, Erar B, Kahn SE, Knowler WC, Lipkin EW, Kitabchi AE, Wagenknecht LE, Wing RR; Genetic Subgroup of Look AHEAD; Look AHEAD Research Group. Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial. Human Heredity 2013;75:160-74. PMID: 24081232

43. Cheng CY, Schache M, Ikram MK, Young TL, Guggenheim JA, Vitart V, MacGregor S, Verhoeven VJ, Barathi VA, Liao J, Hysi PG, Bailey-Wilson JE, St Pourcain B, Kemp JP, McMahon G, Timpson NJ, Evans DM, Montgomery GW, Mishra A, Wang YX, Wang JJ, Rochtchina E, Polasek O, Wright AF, Amin N, van Leeuwen EM, Wilson JF, Pennell CE, van Duijn CM, de Jong PT, Vingerling JR, Zhou X, Chen P, Li R, Tay WT, Zheng Y, Chew M; Consortium for Refractive Error and Myopia, Burdon KP, Craig JE, Iyengar SK, Igo RP Jr, Lass JH Jr; Fuchs' Genetics Multi-Center Study Group, Chew EY, Haller T, Mihailov E, Metspalu A, Wedenoja J, Simpson CL, Wojciechowski R, Höhn R, Mirshahi A, Zeller T, Pfeiffer N, Lackner KJ; Wellcome Trust Case Control Consortium 2, Bettecken T, Meitinger T, Oexle K, Pirastu M, Portas L, Nag A, Williams KM, Yonova-Doing E, Klein R, Klein BE, Hosseini SM, Paterson AD; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions, and Complications Research Group, Makela KM, Lehtimaki T, Kahonen M, Raitakari O, Yoshimura N, Matsuda F, Chen LJ, Pang CP, Yip SP, Yap MK, Meguro A, Mizuki N, Inoko H, Foster PJ, Zhao JH, Vithana E, Tai ES, Fan Q, Xu L, Campbell H, Fleck B, Rudan I, Aung T, Hofman A, Uitterlinden AG, Bencic G, Khor CC, Forward H, Pärssinen O, Mitchell P, Rivadeneira F, Hewitt AW, Williams C, Oostra BA, Teo YY, Hammond CJ, Stambolian D, Mackey DA, Klaver CC, Wong TY, Saw SM, Baird PN. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. American Journal of Human Genetics 2013;93:264-77. PMCID: PMC3772747

44. Nathan DM, Bayless M, Cleary P, Genuth S, Gubitosi-Klug R, Lachin JM, Lorenzi G, Zinman B; DCCT/EDIC Research Group. Diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: advances and contributions. Diabetes 2013;62(12):3976-86. PMCID: PMC3837056

45. Buford TW, Hsu FC, Brinkley TE, Carter CS, Church TS, Dodson JA, Goodpaster BH, McDermott MM, Nicklas BJ, Yank V, Johnson JA, Pahor M; LIFE Research Group. Genetic influence on exercise-induced changes in physical function among mobility-limited older adults. Physiology Genomics 2014;1;46(5):149-58. PMCID: PMC3949106

46. Unick JL, Hogan PE, Neiberg RH, Cheskin LJ, Dutton GR, Evans-Hudnall G, Jeffery R, Kitabchi AE, Nelson JA, Pi-Sunyer FX, West DS, Wing RR; Look AHEAD Research Group. Evaluation of early weight loss thresholds for identifying nonresponders to an

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intensive lifestyle intervention. Obesity (Silver Spring). 2014;22:1608-16. PMCID: PMC4077939

47. Vaz Fragoso CA, Beavers DP, Hankinson JL, Flynn G, Berra K, Kritchevsky SB, Liu CK, McDermott MM, Manini TM, Rejeski WJ, Gill TM; Lifestyle Interventions Independence for Elders Study Investigators. Respiratory impairment and dyspnea and their associations with physical inactivity and mobility in sedentary community-dwelling older persons. Journal of the American Geriatrics Society 2014;62(4):622-8. PMCID: PMC3989438

48. Wing RR for the Look AHEAD Research Group. Implications of Look AHEAD for clinical trials and clinical practice. Diabetes and Obesity Metabolism 2014;16(12):1183-91. PMCID: PMC4227940

49. Simpson CL, Wojciechowski R, Oexle K, Murgia F, Portas L, Li X, Verhoeven VJ, Vitart V, Schache M, Hosseini SM, Hysi PG, Raffel LJ, Cotch MF, Chew E, Klein BE, Klein R, Wong TY, van Duijn CM, Mitchell P, Saw SM, Fossarello M, Wang JJ; DCCT/EDIC Research Group, Polašek O, Campbell H, Rudan I, Oostra BA, Uitterlinden AG, Hofman A, Rivadeneira F, Amin N, Karssen LC, Vingerling JR, Döring A, Bettecken T, Bencic G, Gieger C, Wichmann HE, Wilson JF, Venturini C, Fleck B, Cumberland PM, Rahi JS, Hammond CJ, Hayward C, Wright AF, Paterson AD, Baird PN, Klaver CC, Rotter JI, Pirastu M, Meitinger T, Bailey-Wilson JE, Stambolian D. Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci. PLoS One 2014;18;9(9):e107110. PMCID: PMC4169415

50. Rubin RR, Wadden TA, Bahnson JL, Blackburn GL, Brancati FL, Bray GA, Coday M, Crow SJ, Curtis JM, Dutton G, Egan C, Evans M, Ewing L, Faulconbridge L, Foreyt J, Gaussoin SA, Gregg EW, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Knowler WC, Lang W, Lewis CE, Montez MG, Murillo A, Nathan DM, Patricio J, Peters A, Pi-Sunyer X, Pownall H, Rejeski WJ, Rosenthal RH, Ruelas V, Toledo K, Van Dorsten B, Vitolins M, Williamson D, Wing RR, Yanovski SZ, Zhang P; Look AHEAD Research Group. Impact of intensive lifestyle intervention on depression and health-related quality of life in type 2 diabetes: the Look AHEAD Trial. Diabetes Care 2014 Jun;37(6):1544-53. PMID: 24855155

51. Vaz Fragoso CA, Hsu FC, Brinkley T, Church T, Liu CK, Manini T, Newman AB, Stafford RS, McDermott MM, Gill TM; LIFE Study Group. Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations. Journal of the American Medical Directors Association 2014;15(9):665-70. PMCID: PMC4145029

52. Vaz Fragoso CA, Miller ME, Fielding RA, King AC, Kritchevsky SB, McDermott MM, Myers V, Newman AB, Pahor M, Gill TM; Lifestyle Interventions and Independence in Elder Study Group. Sleep-wake disturbances in sedentary community-dwelling elderly adults with functional limitations. Journal of the American Geriatrics Society 2014;62(6):1064-72 PMCID: PMC4057978

53. Raynor HA, Anderson AM, Miller GD, Reeves R, Delahanty LM, Vitolins MZ, Harper P, Mobley C, Konersman K, Mayer-Davis E; the Look AHEAD Research Group; the Look AHEAD Research Group. Partial meal replacement plan and quality of the diet at 1 year: Action for Health in Diabetes (Look AHEAD) Trial. Journal of the Academy of Nutrition and Diet 2015;115:731-742. PMCID: PMC4410067

54. Botoseneanu A, Ambrosius WT, Beavers DP, de Rekeneire N, Anton S, Church T, Folta SC, Goodpaster BH, King AC, Nicklas BJ, Spring B, Wang X, Gill TM; LIFE Study Groups. Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders

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Study participants. Journal of the American Geriatrics Society 2015;63(2):222-32. PMCID: PMC4333053

55. Bann D, Hire D, Manini T, Cooper R, Botoseneanu A, McDermott MM, Pahor M, Glynn NW, Fielding R, King AC, Church T, Ambrosius WT, Gill T; LIFE Study Group. Light Intensity physical activity and sedentary behavior in relation to body mass index and grip strength in older adults: cross-sectional findings from the Lifestyle Interventions and Independence for Elders (LIFE) study. PLoS One. 2015 Feb 3;10(2):e0116058. doi: 10.1371/journal.pone.0116058. PMCID: PMC4315494

56. Fitzgerald JD, Johnson L, Hire DG, Ambrosius WT, Anton SD, Dodson JA, Marsh AP, McDermott MM, Nocera JR, Tudor-Locke C, White DK, Yank V, Pahor M, Manini TM, Buford TW; LIFE Study Research Group. Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults. Journal of the American Heart Association 2015;18;4(2). PMCID: PMC4345863

57. Pownall HJ, Bray GA, Wagenknecht LE, Walkup MP, Heshka S, Hubbard VS, Hill J, Kahn SE, Nathan DM, Schwartz AV, Johnson KC; Look AHEAD Research Group. Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: the look AHEAD study. Obesity (Silver Spring). 2015;23(3):565-72. doi: 10.1002/oby.21005. PMID: 25707379

58. Rejeski WJ, Rushing J, Guralnik JM, Ip EH, King AC, Manini TM, Marsh AP, McDermott MM, Fielding RA, Newman AB, Tudor-Locke C, Gill TM; LIFE Study Group The MAT-sf: identifying risk for major mobility disability. Journal of Gerontology Medical Sciences 2015;70:641-6. PMCID: PMC4447779

59. Sarma AV, Hotaling J, Dunn RL, Cleary PA, Braffett BH, Kim C, Martin C, Herman W, Gatcomb P, Jacobson AM, Holt SK, Wessells H; DCCT/EDIC Research Group. Poor glycemic control is associated with reduced prostate specific antigen concentrations in men with type 1 diabetes. Journal of Urology 2015;193(3):786-93. PMCID: PMC4363040

60. Unick JL, Neiberg RH, Hogan PE, Cheskin LJ, Dutton GR, Jeffery R, Nelson JA, Pi-Sunyer X, West DS, Wing RR; Look AHEAD Research Group. Weight change in the first 2 months of a lifestyle intervention predicts weight changes 8 years later. Obesity (Silver Spring). 2015;23(7):1353-6. PMCID: PMC4481874

61. Belalcazar LM, Lang W, Haffner SM, Schwenke DC, Kriska A, Balasubramanyam A, Hoogeveen RC, Pi-Sunyer FX, Tracy RP, Ballantyne CM; Look AHEAD (Action for Health in Diabetes) Research Group. Improving adiponectin levels in individuals with diabetes and obesity: insights from Look AHEAD. Diabetes Care 2015 Aug;38(8):1544-50. doi: 10.2337/dc14-2775. Epub 2015.PMID: 25972574

62. Look AHEAD Research Group. Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial. Diabetologia 2015 Aug;58(8):1803-13. doi: 10.1007/s00125-015-3610-z. Epub 2015 May 14. PMID: 25972230

63. Ravussin E, Redman LM, Rochon J, Das SK, Fontana L, Kraus WE, Romashkan S, Williamson DA, Meydani SN, Villareal DT, Smith SR, Stein RI, Scott TM, Stewart TM, Saltzman E, Klein S, Bhapkar M, Martin CK, Gilhooly CH, Holloszy JO, Hadley EC, Roberts SB; CALERIE Study Group. A 2-year randomized controlled trial of human caloric restriction: feasibility and effects on predictors of health span and longevity. Journal of Gerontology Medical Sciences 2015;70:1097-104. PMID 26187233

64. Bondoc I, Cochrane SK, Church TS, Dahinden P, Hettwer S, Hsu FC, Stafford RS, Pahor M, Buford TW; Life Study Investigators. Effects of a one-year physical activity program on serum C-Terminal Agrin Fragment (CAF) concentrations among mobility-limited older

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adults.Journal of Nutrition and Health in Aging 2015;19(9):922-7. PMID: 26482694 65. McCaffery JM, Papandonatos GD, Faulconbridge LF, Erar B, Peter I, Wagenknecht LE,

Pajewski NM, Anderson A, Wadden TA, Wing RR; Look AHEAD Research Group. Genetic predictors of depressive symptoms in the Look AHEAD Trial. Psychosomatic Medicine 2015;77(9):982-92.PMCID: PMC4643359

66. King AC, Salvo D, Banda JA, Ahn DK, Gill TM, Miller M, Newman AB, Fielding RA, Siordia C, Moore S, Folta S, Spring B, Manini T, Pahor M; LIFE Study Investigators. An observational study identifying obese subgroups among older adults at increased risk of mobility disability: do perceptions of the neighborhood environment matter? International Journal of Behavioral Nutritional Physical Activity 2015;12:157. PMID: 26684894

67. Dotson VM, Hsu FC, Langaee TY, McDonough CW, King AC, Cohen RA, Newman AB, Kritchevsky SB, Myers V, Manini TM, Pahor M. LIFE study group. Genetic moderators of the impact of physical activity on depressive symptoms. Journal of Frailty and Aging 2016;5(1):6-14. PMID: 26980363.

68. Marsh AP, Applegate WB, Guralnik JM, Jack Rejeski W, Church TS, Fielding RA, Gill TM, King AC, Kritchevsky SB, Manini TM, McDermott MM, Newman AB, Stowe CL, Walkup MP, Pahor M, Miller ME; LIFE Study Investigators. Hospitalizations during a physical activity intervention in older adults at risk of mobility disability: analyses from the Lifestyle Interventions and Independence for Elders randomized clinical trial. Journal of the American Geriatrics Society 2016;64(5):933-43. PMID: 27225353

69. Layne AS, Hsu FC, Blair SN, Chen SH, Dungan J, Fielding RA, Glynn NW, Hajduk AM, King AC, Manini TM, Marsh AP, Pahor M, Pellegrini CA, Buford TW; LIFE Study Investigators. Predictors of change in physical function in older adults in response to long-term, structured physical activity: The LIFE Study. Archives of Physical and Medical Rehabilitation 2017;98(1):11-24.e3.

70. Aubertin-Leheudre M, Anton S, Beavers DP, Manini TM, Fielding R, Newman A, Church T, Kritchevsky SB, Conroy D, McDermott MM, Botoseneanu A, Hauser ME, Pahor M; LIFE Research Group. Dynapenia and metabolic health in obese and nonobese adults aged 70 years and older: The LIFE Study. Journal of the American Medical Directors Association 2017;18:312-319. PMCID: PMC5366275.

71. Effoe VS, Kaatula JA, Kirk JK, Pedley CF, Bolhalter LY, Brown WM, Savoca MR, Jones SAT, Baek J, Bertoni AG and the LIFT Diabetes Research Team. The use of electrnic medical records for recruitment in clinical trials: findings from the Lifestyle Intervention for Treatment of Diabetes Trial. Trials 2016;17:496. PMCID: PMC5062894

72. Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM; LIFE Study Investigators. Social participation modifies the effect of a structured physical activity program on major mobility disability among older adults: results from the LIFE Study. Journal of Gerontology B Psychological Sciences Social Sciences 2017 May 8. doi: 10.1093/geronb/gbx051. [Epub ahead of print] PMID: 28482106

Book Chapters

1. Furberg CD, Byington R, Espeland M. "Should a change in the atherosclerotic process be required for approval of new hypolipidemic agents?" in Risk/Benefit Analysis for the Use and Approval of Thrombolytic, Antiarrhythmic, and Hypolipidemic Agents. Boston: Kluwer Academic Publishers, 1989.

2. Cefalu CA, Ettinger WH, Espeland M. “Factors associated with dementia patients leaving adult day care” in Facts and Research in Gerontology 1996. Auzeville, France:

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Societe D’Etude, Realisationet Diffusion Internationale, 1996.

3. Crouse JR, Furberg CD, Espeland MA, Riley WA. “B-mode ultrasound: a noninvasive method for assessing atherosclerosis” in Cardiovascular Medicine, 3rd Ed. London: Springer-Verlag, 2007.

4. Espeland MA, Shumaker SA, Hogan PE, Resnick SM. Women’s Health Initiative Memory Study (WHIMS) program: emerging findings. Ed.: Hogervorst E, Henderson V, Gibbs R, Brinton R. Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies. Cambridge: Cambridge University Press, 2009.

5. Bandelow S, Espeland M, Resnick S, Henderson VW, Coker L, Wallace R, Hogervorst E. Identifying risk factors for cognitive change in the Women’s Health Initiative: a neural networks approach. EdL Hogervorst E, Henderson V, Gibbs R, Brinton R. Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies. Cambridge: Cambridge University Press, 2009.

6. Driscoll I, Espeland MA, Yaffe K. Cognitive functioning in aging women. Ed. Levelle S. Women and Health, 2nd Edition. Elsevier Press, San Diego, 2012.

7. Allore H, Espeland MA, Miller ME. Statistical issues in designing and interpreting clinical trials in older adults. Ed: Antonio Cherubini A, Bernabei R, Ferrucci L, Marchionni N, Studenski S, Vellas B. Clinical Trials in Older Adults. Oxford: John Wiley, 2015.

8. Driscoll I, Rapp SR, Johnson KC, Espeland MA. Hormone therapy in postmenopausal women: The Women’s Health Initiative and its continuing impact on research and practice (under review).

9. Espeland MA, Small DM, Stoeckel LE. Book chapter: Diet, obesity, and physical inactivity: linking diabetes and dementia. Editors: Srikanth A, Arvanitkis Z. Type 2 Diabetes and Dementia. London: Elsevier. 2017 (in press).

Abstracts and Major Presentations

1. Inglis J, Espeland M. Application of Dirichlet process priors to sampling finite populations. International Mathematical Statistics Bulletin 1976;5:121.

2. Espeland M, Odoroff C. Fitting log-linear models to contingency tables with mixed-up cells. American Statistical Association, Washington DC, 1979.

3. Espeland M, Odoroff C. Log-linear models for doubly sampled categorical data. American Statistical Association, Detroit, 1981.

4. Platt O, Rosenstock W, Espeland M, Gaston M. Height and weight of patients with sickle cell disease. Annual Sickle Cell Disease Conference, Howard University, 1982.

5. Anderson R, Espeland M. Generalized least squares regression with a patterned covariance. American Statistical Association, Cincinnati, 1983.

6. Gregory J, Blood J, Arlook J, Farber M, Espeland M. Results from a national survey on working women and stress. American Public Health Association, Anaheim, 1984.

7. Baric J, Berglund K, Espeland M, Handelman S. Prevalence of hyposalivary drug use in the institutionalized elderly. American Public Health Association, Anaheim, 1984.

8. Mundorff S, Eisenberg A, Shields C, Featherstone J, Espeland M. Correlation between food fluoride, plaque, microbiology and rat caries. Food Nutrition and Dental Health, Atlanta, 1984.

9. Espeland M, Mundorff S, Featherstone J, Eisenberg A, Shields C, Curzon M. Cariogenicity of foods: statistical analysis. Journal of Dental Research 1985;64;294.

10. Mundorff S, Featherstone J, Eisenberg A, Espeland M, Shields C, Curzon M. Cariogenicity of foods: rat study. Journal of Dental Research 1985;64;294.

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11. Handelman S, Espeland M, Curzon J, Leverett D. Retention of sealants over carious and sound tooth surfaces. Journal of Dental Research 1985;64:225.

12. Stege P, Espeland M, Saunders R, Handelman S. Dentists' communication leads during a geriatric patient interview. Journal of Dental Research 1985;64:345.

13. Krobicka A, Bowen W, Espeland M. The effect of ingestion of cheese and peanuts on composition of saliva from rats. Journal of Dental Research 1985;64:188.

14. Zappa U, Polson A, Espeland M, Eisenberg A. Effect of Metronidazole on development of subgingival plaque and experimental periodontitis. Journal of Dental Research 1985;64:360.

15. Roberts C, Tallents R, Espeland M, Handelman S, Katzberg R. Mandibular range of motion vs. arthrographic findings in 205 patients. Journal of Dental Research 1985;64:231.

16. Anderson R, Espeland M. Regression analysis of ophthalmologic data using generalized least squares. 2nd NEI Symp. Eye Disease Epidemiology, 1985.

17. Curzon M, Featherstone J, Mundorff S, Espeland M, Shields C. Food composition and cariogenicity of foods. ORCA Congress, Abs. 96.

18. Espeland M, Hui S. The analysis of discrete data subject to misclassification. American Statistical Association, Las Vegas, 1985.

19. Holden C, Handelman S, Baric J, Saunders R, Espeland M. Psychotropic drug use, psychiatric diagnosis and oral/dental health in a geriatric population. IVth World Congress on Biological Psychiatry, 1985.

20. Baric J, Espeland M, Saunders R, Handelman S. Mouth dryness, salivary flow and drug use in nursing home residents. American Public Health Association, Washington, 1985.

21. Saunders R, Handelman S, Espeland M, Baric J. Salivary flow and dental health in an elderly population. Journal of Dental Research 1986;65:215.

22. Watkins C, Saunders R, Espeland M, Handelman S. Nonverbal behavior of older patients during an initial dental visit. Journal of Dental Research 1986;65:171.

23. Graser G, Plekavich E, Espeland M. Anthropomorphic measurements for anterior tooth position and vertical dimensions of occlusion. Journal of Dental Research 1986;65:249.

24. Mundorff S, Eisenberg A, Espeland M, Leverett D. Correlation between plaque and salivary microflora. Journal of Dental Research 1986;65:215.

25. Skeels D, Saunders R, Espeland M, Handelman S. Geriatric patients' verbal communication leads during an initial dental interview. Journal of Dental Research 186;65:171.

26. Eisenberg A, Mundorff S, Espeland M, Leverett D. Association of S. mutans, lactobacilli and TVF with DMFS status or region. Journal of Dental Research 1986;65:216.

27. Handelman SL, Espeland MA, Curzon J, Leverett DH. Clinical radiographic evaluation of sealed carious and sound tooth surfaces. Journal of Dental Research 1986;65:172.

28. Leverett DH, Adair SM, Espeland MA. Relationship of dental fluorosis and prior exposure to systematic fluorides. Journal of Dental Research 1986;65:234.

29. Zdanowicz JA, Featherstone JDB, Espeland MA, Curzon MEJ. Inhibitory effect of barium on human caries prevalence. Journal of Dental Research 1986;65:283.

30. Rossopoulos ET, Graser GN, Espeland MA. Accuracy of denture bases: a comparative study of the dimensional change between the completed base (double process) technique and the conventional (single process) technique. European Prosthodontics Association, Athens, 1986.

31. Skeels D, Saunders R, Espeland M, Handelman S. The impact of the patient's verbal behavior on an initial dental interview. Journal of Dental Research 1986;65:809.

32. Handelman S, Baric J, Espeland M, Saunders R. Hyposalivation, drug use and caries in

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the elderly. Journal of Dental Research 1986;65:816.

33. Leverett D, Adair S, Espeland M. Patterns of dental fluorosis among primary and secondary school children in an optimally fluoridated community. Journal of Dental Research 1986;65:780.

34. Zappa U, Polson A, Espeland M. Effect of Metronidazole on development of experimental periodontitis: cell population characteristics. Journal of Dental Research 1986;65:805.

35. Bouwsma O, Polson A, Espeland M. Effect of Tetracycline on microbial populations and experimental periodontitis. Journal of Dental Research 1986;65:805.

36. Espeland M, Murphy W, Leverett D. Assessing diagnostic reliability and estimating incidence rates associated with a strictly progressive disease. American Statistical Association, Chicago, 1986.

37. Hutta JW, Morris T, Katzberg R, Tallents R, Espeland M. A comparison of arthrography and joint sound analysis in TMJ internal derangements. Radiological Society of North America, 1986.

38. Katzberg R, Westesson PL, Tallents R, Sanchez-Woodworth R, Espeland M. Comparison of MR and cryosectional anatomy in the normal and abnormal temporomandibular joint. Radiological Society North America, 1986.

39. Bouwsma O, Caton J, Polson A, Espeland M. Effect of personal oral hygiene on bleeding interdental gingiva: histologic changes. Journal of Dental Research 1987;66:255.

40. Zappa UE, Polson AM, Espeland M. Correlations between active periodontal breakdown and cell populations. Journal of Dental Research 1987;66:172.

41. Roberts CA, Tallents RH, Espeland MA, Handelman SL, Katzberg RW. Correlation of clinical findings with arthrographic diagnosis in TMJ patients. Journal of Dental Research 1987;66:337.

42. Katzberg RW, Westesson PL, Tallents RH, Sanchez-Woodworth RE, Svensson SA,

Espeland MA. Comparison between magnetic resonance imaging and sagittal cryosectional anatomy of normal and abnormal temporomandibular joints. Journal of Dental Research 1987;66:337.

43. Assimos DG, Boyce WH, Furr EG, Espeland MA, Harrison LH, Kroovand RL. Urinary enzyme levels after extracorporeal shock wave lithotripsy. Journal of Urology 1987;143A:137.

44. Holden JMC, Handelman SL, Baric JM, Saunders RL, Espeland MA. Psychotropic drug use psychiatric diagnosis and oral/ dental health in a geriatric population. International Journal of Neuropsychiatry 1987;32:312.

45. Espeland MA, Handelman SL. Using latent structure models to characterize and asses relative error in discrete measurements. American Statistical Association, San Francisco, 1987.

46. Wells HB, Espeland MA, Morgan T. Analyzing toxicity in chemotherapy trials. Controlled Clinical Trials 1987;8(3):290.

47. Ryu JE, Espeland MA, Kahl FR, Thompson CJ, Crouse JR. Adipose distribution in females is associated with coronary artery disease. Circulation 1987;76(4):396.

48. Jarow JP, Espeland MA. Evaluation of the azoospermic male. Journal of Andrology 1988;9(1):36-P.

49. Espeland MA, Jensen OE, Hogan PE, Handelman SL. Characterizing relative error in the radiographic diagnosis of dental caries. Journal of Dental Research 1988;67:286.

50. West MS, Espeland MA. Statistical methods for the analysis of serial data in dental research. Journal of Dental Research 1988;67:389.

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51. Eisenberg AD, Mundorff SA, Leverett DH, Adair SM, Espeland MA, Proskin HM. Association of S. mutans, lactobacilli, and plaque index with DMFS or water fluoridation. Journal of Dental Research 1988;67:230.

52. Crouse JR, Kahl FR, McKinney WM, Espeland MA, Ryu JE, Toole JF. The relationship of risk factors to coronary and carotid atherosclerosis. 8th International Symposium on Atherosclerosis, 1988.

53. Espeland MA, Platt OS, Gallagher D. Joint estimation of incidence and diagnostic error rates from irregular longitudinal data. American Statistical Association, New Orleans, 1988.

54. Kofinas AD, Espeland MA, Swain M, Penry M, Nelson L. Correcting umbilical artery flow velocity waveforms for fetal heart rate is unnecessary. International Perinatal Doppler Society, Kansas City, 1988.

55. Espeland MA, Hogan PE, Zappa UE. Design issues related to longitudinal studies of progressive dichotomous outcome measures that are subject to misdiagnosis. Controlled Clinical Trials 1989;10:317.

56. Byington RP, Espeland MA, Brugger S, Worthy J. Progression of carotid atherosclerotic plaque as an endpoint in a clinical trial: the Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS). Controlled Clinical Trials 1989;10:349.

57. Hogan P, Zappa U, Graf H, Espeland M. Reliability issues in measuring loss of attachment. Journal of Dental Research 1989;68:360.

58. Graf H, Zappa U, Espeland M. Distribution of inflammatory cells in progressing and stationary periodontal lesions. Journal of Dental Research 1989;68:1020.

59. Zappa U, Reinking-Zappa M, Espeland M, Graf H. Cell populations and episodic periodontal attachment loss. Journal of Dental Research 1989;68:1020.

60. Espeland MA. Sample size requirements and analysis issues. International Workshop on Progression and Regression of Carotid Atherosclerosis in Clinical Trials, Winston-Salem, 1989.

61. Kofinas AD, Espeland MA, Penry M, Hatjis CG. Uteroplacental doppler flow velocity waveform indices in normal pregnancy: a statistical exercise and the development of appropriate reference values. Society of Perinatal Obstetricians, 1990.

62. Freedman B, Espeland M, Canzanello V. HLA antigenic differences do not explain inter-racial variation in prevalence of hypertensive end stage renal disease. American Society of Hypertension, New York, 1990.

63. Espeland MA, Devault A. Estimating the incidence distribution for bivariate processes when diagnosis is subject to error. Biometric Society--Eastern North America Regional Meeting, Baltimore, 1990.

64. Espeland MA, Verter J. Statistical design of the Postmenopausal Estrogen/ Progestin Intervention trial. Controlled Clinical Trials 1990;11(4):263.

65. Evans GW, Espeland MA, Case LD, Muss HB. Resampling methods for repeated measures in clinical trials. Controlled Clinical Trials, 1990;11(4):261.

66. Espeland M, Wethers D, Platt O. Characteristics of growth and sexual maturation among persons with sickle cell disease. Comprehensive Sickle Cell Centers' Annual Meeting, Berkeley, 1990.

66. Smith J, Flournoy-Gill Z, Espeland M, Bellevue R, Brown A, Dosik H, Koshy M, Reider R, Walters I. Pregnancy in sickle cell disease. Comprehensive Sickle Cell Centers' Annual Meeting, Berkeley, 1990.

67. Espeland MA. Survey of methods for the analysis of longitudinal data. Annual meetings of the VA Cooperative Trials Group, Toronto, 1990.

68. Howard G, Evans GW, Tell G, Rose LA, Espeland M, Truscott BL. Characteristics of

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stroke victims associated with early cardiovascular mortality in their children. Stroke 1990;21:970.

69. Freedman B, Brockschmidt J, Espeland M, Heise E, Canzanello V. Racial differences in HLA antigen frequency in diabetic nephropathy. Journal of the American Society of Nephrology 1990;1:290.

70. Wang W, Grover R, Flournoy-Gill Z, Espeland M, Fandel A. The CSSCD study of the development of young children with sickle cell disease -- results of the Denver Developmental Screening Test (DDST). Comprehensive Sickle Cell Centers' Annual Meeting, Atlanta, 1991.

71. Espeland M, Davis V, Hartwell T, Byington R. Analysis strategies for serial multivariate data that are incomplete. Annual meetings of the American Statistical Association, Atlanta, 1991.

72. Espeland MA, Thomas JL, Case LD. Models for discrete bivariate error. Annual Meeting of the Eastern North American Region Biometrics Society, Houston, 1991.

73. Thomas JL, Case LD, Espeland MA. Efficiency of jointly modeling diagnostic error and incidence of progressive dichotomous processes. Annual Meeting of the Eastern North American Region Biometrics Society, Houston, 1991.

74. Howard G, Espeland MA, Layard M. A rerandomization approach for meta-analysis of dose-response relationships. Annual meetings of the American Statistical Association, Atlanta, 1991.

75. Evans GW, Smith ML, Espeland MA, Case LD, Craven TE. Cross-validation versus bootstrap estimates of excess error in CART. Annual meetings of the American Statistical Association, Atlanta, 1991.

76. Zappa U, Simona C, Graf H, Espeland M. Reliability of single and double attachment level measurements. Journal of Dental Research 1991;70(S):282.

77. Jarow JP, Wolfman N, Bechtold R, Tegler C, Espeland MA, Watson NE. Testicular arterial blood flow of infertile men with and without varicocele. Annual meetings of The American Fertility Society, 1991.

78. Renfroe WO, Espeland MA. The effect of frequency of screening on test performance in screening for hypercholesterolemia. Medical Decision Making 1991;11:323.

79. Freedman BI, Espeland MA, Heise ER, Canzanello ZJ. Racial differences in HLA antigen frequency in hypertensive renal failure and diabetic nephropathy. NIH Workshop on the Biology of Kidney Disease and Hypertension in Blacks.

80. Espeland MA, Thomas J. Modeling categorical error. Annual meetings of the Eastern North American Region Biometrics Society, Cincinnati, 1992.

81. Espeland MA, Davis V, Byington RP, Riley W, Craven TE, Hartwell T, Probstfield J. Design issues for studies based on ultrasonography of the carotid artery intimal-medial thickness. Controlled Clinical Trials 1992;13:379.

82. Cefalu CA, Ettinger WH, Espeland M. Risk factors for dementia clients leaving day care. Annual meetings of the American Geriatrics Society, November, 1992.

83. Freedman BI, Spray BJ, Heise ER, Espeland MA, Canzanello VJ. A race-controlled HLA frequency analysis in lupus nephritis. Journal of the American Society of Nephrology 1992;3:331.

84. Furberg CD, Crouse JR, Furberg CD, Byington RP, Bond MG, Espeland MA. PLAC-2: effects of pravastatin on atherosclerosis progression and clinical events. The Journal of the American College of Cardiologists, 1993;21:71A.

85. Espeland M, Appel L, Hogan P. Statistical issues in the design of the Trial of Nonpharmacologic Interventions in the Elderly (TONE). Controlled Clinical Trials 1993;14:433.

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86. Hoen H, Espeland M, Riley W, Furberg C. Summarizing carotid intimal-medial thickness in the Asymptomatic Carotid Artery Plaque Study. Controlled Clinical Trials 1993;14:433.

87. Cefalu CA, Ettinger WA, Espeland MA. Risk factors for dementia clients leaving adult day care. Primary Care Research Conference, Atlanta, 1993.

88. Cefalu CA, Ettinger WH, Espeland M. Characteristics of a dementia non-specific adult day-care population. American Geriatrics Society/American Federation for Aging Research, New Orleans, 1993.

89. Mercuri M, Tang T, Espeland M, Byington R, Bond MG, Borhani N. Does isradipine vasodilate common carotid arteries? The MIDAS database. International Society for Hypertension, Melbourne, 1994.

90. Appel LJ, Whelton PK, Espeland MA. Trial of nonpharmacologic interventions in the elderly trial: design and rationale. International Society for Hypertension, Melbourne , 1994.

89. Mercuri M, Tang T, Espeland M, Byington R, Bond MG, Borhani N. Does isradipine vasodilate common carotid arteries? The MIDAS database. American College of Cardiology, Melbourne, 1994.

90. Mercuri M, Flack J, Nichols F, Prisant M, Espeland M, Batcheller A, Eddleman E, Gore I, Lee M. Effects of isradipine and hydrochlorothiazide on carotid intima media thickness of cardiovascular asymptomatic hypertensives. World Cardiology Conference, Berlin, 1994.

91. Mercuri M, Tang R, Espeland M, Byington R, Bond MG, Borhani N. Does isradipine vasodilate common carotid arteries? The MIDAS database. Atherosclerosis 1994;109:158.

92. Riley WA, Hoen H, Espeland M for the ACAPS Study Group. Site specific differences in progression of carotid intimal-medial thickness in the asymptomatic carotid artery plaque study (ACAPS). World Cardiology Conference, Berlin, 1994.

93. Furberg CD, Hoen HM, Espeland MA, Applegate WB, Bendixes BH. Effect of lovastatin on early carotid atherosclerosis in women. Atherosclerosis 1994;109:158.

94. Craven T, Espeland M, Hoen H for the ACAPS Investigators. Comparison of methods to analyze longitudinal B-mode ultrasound data: Results from the ACAPS trial. Controlled Clinical Trials 1994;15:79S.

95. Hoen H, Craven T, Espeland M, Byington B for the ACAPS Investigators. Increased efficiency in applying missing data methodology to carotid atherosclerosis outcome measures. Controlled Clinical Trials 1994;15:78S.

96. Espeland MA, Applegate WB, Hunninghake D, Lefkowitz D, Rice L, Furberg CD. Relative impact of lovastatin and estrogen replacement therapy on progression of intimal medial thickness in the carotid arteries. Atherosclerosis 1994;109:154.

97. Espeland MA, Applegate WB, Hunninghake D, Lefkowitz L, Furberg CD. Hormone replacement therapy and progression of intimal-medial thickness in the carotid arteries in postmenopausal women. Circulation 1994;90:I-128.

98. Mercuri M, Tang R, Espeland M, Byington R, Bond MG, Borhani N. Does isradipine vasodilate common carotid arteries? The MIDAS experience. Atherosclerosis 1994;109:294.

99. Furberg CD, Hoen HM, Espeland MA, Applegate WB, Bendixen BH. Effect of lovastatin on early carotid atherosclerosis in women. Atherosclerosis 1994;109:158.

100. Bradham KH, Dolecek TA, Espeland MA, Margitic SE, Byington RP. Dietary intervention to lower serum LDL-cholesterol and meet NCEP-ATP guidelines in a drug lipid lowering clinical trial. Journal of the American Dietetic Association 1994;94:A-82.

101. Espeland MA. Invited discussant: "Handling drop-out in efficacy trials." Annual meeting of the ENAR-Biometrics Association, April 1994.

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102. Espeland MA, Applegate WB, Hunninghake D, Lefkowitz D, Rice L, Furberg CD. Hormone replacement therapy and progression of intimal-medial thickness in the carotid arteries in postmenopausal women. Circulation 1994;90(4):Part 2.

103. Craven T, Espeland M, Hoen H, Byington B. Longitudinal variability of ultrasonographic measurements of carotid intimal-medial thickness: results from ACAPS. Controlled Clinical Trials 1996;17(2S):127S.

104. TONE Collaborative Group. Effects of weight loss and sodium reduction on blood pressure control: The Trial of Nonpharmacologic Interventions in the Elderly (TONE). The International Society of Hypertension, Glasgow, 1996.

105. Shindler DM, Hoagland D, Espeland M, Lacy CR, Bottom JB, Hemphill S, Wan JY, Tayback M, Kostis JB. Differences between self-reported and clinic-measured height and weight in elderly hypertensives. American College of Cardiology, 1996.

106. Espeland MA. Richard D. How to deal with incomplete outcome measures. Annual Remington Methodology Lecture, AHA Conference on Cardiovascular Disease Epidemiology and Prevention, San Francisco, 1996.

107. Craven T, Espeland M, Hoen H, Byington R. Longitudinal variability of ultrasonographic measurements of carotid intimal-medial thickness: results for ACAPS. Controlled Clinical Trials 1996;17:127S.

108. Whelton PW, Applegate WB, Ettinger WH, Espeland M, Kostis JB, Appel LJ, Cutler JA, Premen AJ. Efficacy of weight loss and reduced sodium intake in the Trial of Nonpharamcologic Interventions in the Elderly (TONE). Circulation 1996;94:I-178.

109. Espeland MA, Kostis JB, Whelton PK, Carnaghi M, Elam J, Bahnson J. Predictors of successful long term weaning from antihypertensive medications. Canadian Journal of Cardiology 1997;13(SupplB):204B.

110. Appel LJ, Espeland MA, Doroshenko L, Bottom J, Wilson AC, Folmar S. Reduced sodium intake as a means to control high blood pressure in older-aged adults: results from the Trial of Non-pharmacologic Interventions in the Elderly (TONE). Canadian Journal of Cardiology 1997;13(SupplB):206B.

111. Kumanyika SK, Bahnson J, Bottom J, Charleston JB, Folmar S, Wilson AC, Espeland

MA, Whelton PK. Race and sex influences on the efficacy of nonpharmacologic step-down therapy in hypertensive older adults. Canadian Journal of Cardiology 1997; 13(SupplB):369B.

112. Whelton PK, Espeland M, Kostis JB, Appel LJ, Applegate W, Ettinger W, Kumanyika S, Cutler JA. Effect of sodium reduction and weight loss on BP in the Trial of Nonpharmacologic Interventions in the Elderly (TONE). Canadian Journal of Cardiology 1997;13(SupplB):272B.

113. Kostis JB, Espeland M, Lacy CR, Pierce J, Whelton P. Cardiovascular events after antihypertensive drug withdrawal during dietary intervention. Canadian Journal of Cardiology 1997;13(SupplB):203B.

114. Espeland MA, Sherwin R, Bush TL, Marcovina SM, Schrott. Impact of postmenopausal hormone therapy on lipoprotein(a) levels. Canadian Journal of Cardiology 1997;13(SupplB):272B.

115. Melton B, Shumaker S, Espeland M, Rapp S. Women's Health Initiative Memory Study: A trial in preventing dementia. Controlled Clinical Trials 1997;18(3S):99S.

116. Miller ME, Morgan TM, Espeland MA. Group comparisons involving missing data in clinical trials: use of observed versus imputed data. Controlled Clinical Trials 1997;18(3S):99S.

117. Tang R, Mercuri M, Espeland M, Devi K, Bond MG, Crouse J. Arterial structure and function: interrelationships and associations with coronary artery disease.

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Atherosclerosis 1997;134:302.

118. Shumaker SA, Rapp SE, Espeland M, Dugan E. Weaving together the Women's Health Initiative (WHI) and the Women's Health Initiative Memory Study (WHIMS) to advance the health of older women: warp and woof. World Conference of Gerontology, Adelaide, 1997.

119. Espeland MA, Hogan PE, Bush TL, Howard F. Effect of postmenopausal hormone therapy on carbohydrate metabolism. Circulation 1998;97;831.

120. Espeland MA, Stefanick ML, Kritz-Silverstein D, et al. Effect of hormone therapy on weight and girth changes. Menopause Digest 1998;3:13-4.

121. Terry JG, Tang R, Davis DH, Espeland MA, Mercuri M, Bond G, Crouse JR. Associations of arterial dimensions and atherosclerosis of the brachial and carotid arteries are the same in coronary artery disease cases and controls. Circulation 1998;97:828.

122. Espeland MA, Hogan PE, Fineberg SE, et al. Effect of postmenopausal hormone therapy on glucose and insulin concentrations. Menopause Digest 1999;3:29-30.

123. Foster DC, Bush TL, Espeland MA. Hormonal effects on the lower urogenital tract and sexual function: results of the PEPI trial. The International Society for the Study of Vulvovaginal Disease, 1999.

124. Herrington DM, Robertson J, Crouse JR, Espeland MA, McBurnie MA, Burke GL. Hormone replacement therapy and brachial artery endothelial function in older postmenopausal women. Circulation 2000;101:18.

125. Carr JJ, Crouse JR, Cook D, Terry JG, Bartholami B, Espeland M. Cardiac-gated multi-slice computed tomography improves the quantification of coronary calcium. Radiology 2000;217:S-1589.

126. Terry JG, Tang R, Davis DH, Espeland MA, Morgan TM, Crouse JR. Progression of carotid artery atherosclerosis: associations with coronary artery disease and risk factors Circulation 2000;102(18);S-4015.

127. Crouse JR, Herrington DM, Espeland MA, Riley W, McBurnie M, Sutton-Tyrrell K, Burke G. Arterial diameter is increased and flow-mediated brachial artery vasodilation is impaired in individuals older than 70 with cardiovascular disease. The Cardiovascular Health Study. Circulation 2000;102(18);S-4020.

128. Terry JG, Tang R, Davis DH, Foster TP, Morgan TM, Espeland MA, Crouse JR. Arterial remodeling compensates for atherosclerosis in the common carotid, but not in the internal carotid, in participants with coronary artery disease. Circulation 2000;102(18);S-4017.

129. Neves L, Aschner J, Smith T, Espeland M, Averill D, Ferrario C, Brosnihan K. Effects of estrogen replacement on vascular resonses to angiotensin-(1-7) in pressurized rat mesenteric arteries. Journal of Hypertension 2000;18:S76.

130. Wilson A, Kostis J, Philipp C, Appel L, Espeland M, Johnson K, Hooper W. ACE gene (DD) genotype is associated with response to dietary weight loss therapy of hypertension: effect of race and sex. Journal of Hypertension 2000;18:S124.

131. Zaccaro DJ, D’Agostino RB, Wagenknecht LE, Saad MF, Espeland MA, Howard D. Carotid wall thickness progression and insulin resistance. Epidemiology Council, American Heart Association, 2001.

132. Harper M, Berg C, Callaghan, W, Meyer R, Espeland M. The risk of pregnancy related death associated with cesaren section remains after controlling for multiple medical conditions, age, and intrapartum complications. Society for Maternal Fetal Medicine.

133. Espeland MA. Analysis of nutritional data using measurement error models. NC Chapter of the American Statistical Association, September, 2001 (invited presentation).

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134. Shumaker S, Coker L, Legault C, Espeland M, Rapp S, Farmer D, Resnick S, Zonderman A, Maki P. Effects of selective estrogen receptor modulators on cognitive aging: cognition in the Study of Tamoxiphen and Raloxifene (Co-STAR). 7th Annual Graylin Conference: Women’s Cognitive Health, Winston-Salem, October, 2001.

135. Resnick SM, Maki PM, Zonderman AB, Coker LH, Rapp SR, Espeland MA, Shumaker SA. The Women’s Health Initiative Study of Cognitive Aging (WHISCA): Baseline data on cognitive aging in older women. 7th Annual Graylin Conference: Women’s Cognitive Health, Winston-Salem, October, 2001.

136. Shumaker S, Espeland M, Rapp S, Legault C, Jones B, Coker L, Dailey M, Summerville C, Felton D, Jones S. Women’s Health Initiative Memory Study (WHIMS) at completion of Year 5. 7th Annual Graylin Conference: Women’s Cognitive Health, Winston-Salem, October, 2001.

137. Espeland MA, Evans GW, Wagenknecht LE, Crouse JR, Zaccaro DJ. Five year changes in carotid intimal-medial thickness are highly correlated between arteries and among wall segments. Circulation 2003;107(7):P131.

138. Hamman R, Espeland M, Ruggiero A, Dabelea D, Smith C, Liu L, Liese A. Challenges in Estimating completeness of ascertainment using the capture-recapture method. The SEARCH for Diabetes in Youth Study. European Diabetes Epidemiology Group Annual Meetings, 2004.

139. Coker LH, Espeland MA, Gu L, Masaki KH, Rapp SR, Langer RD, Stefanick ML, Ockene J, Shumaker SA. Association between reported alcohol intake and changes in cognition: results from the Women's Health Initiative Memory Study (WHIMS). Geronotologist 2004;44:82-83.

140. Rapp S, Shumaker S, Espeland M. Impact of estrogen alone on global cognitive function in postmenopausal women: the Women’s Health Initiative Memory Study. Gerontologist 2004;44:264.

141. Levy PJ, Smith RD, Brosnihan B, Owen J, Espeland M, Ferrario CM. Effects of irbesartan on platelet aggregation and markers of inflammation in hypertensive patients with and without atherosclerotic cardiovascular disease. Am J Hypertens 2004;17:115A-116A.

142. Espeland MA, O’Leary DH, Terry JG, Morgan T, Evans G, Mudra H. Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors. Clinical Trials 2005;2:S75.

143. Espeland MA, Rapp SR, Robertson J, Albert M, Bassford T, Granek I, Murphy C. Modified Mini-Mental State Exams in two-stage study designs: results from the Women’s Health Initiative Memory Study (WHIMS). Clinical Trials 2005;2:S45.

144. Espeland MA, Dotson K, Foreyt JP, Gaussoin S, Kahn SE, Knowler WC, Montez M, Montgomery B. Level of consent for genetics studies among clinical trial participants: results from the Action for Health in Diabetes (Look AHEAD) Study Group. Clinical Trials 2005;2:S30.

145. Kritchevsky SB, Guralnick JM, Dunn A, Pruitt L, Wallace K, Glynn N, Hsu F-C, Katula K,

Gill T, Studenski S, Pahor M, Espeland MA. Recruiting a functionally limited older population for a trial of physical activity and disability prevention. Gerontological Society of America, 2005.

146. Espeland MA, Fielding R, Gill TM, Guralnik J, Miller ME, Newman A, Pahor M for the Lifestyle Interventions and Independence for Elders Study Group. Design of clinical trials with mobility outcomes: Results from the Lifestyle Interventions and Independence for Seniors (LIFE) Pilot Trial. Gerontological Society of America, 2005.

147. Espeland MA, Regensteiner JG, Hiatt WR, Wagenknecht L, Bahnson J, Chiu K, Gregg

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E, Jaramillo SA, Haffner S, Hill J, Knowler W. A model-based approach to analyzing ankle-brachial index: results from the Action for Health in Diabetes Study Group. American Heart Association annual conference on Cardiovascular Disease Epidemiology and Prevention, March 2006 (Circulation 2006;113(8):E357).

148. Williams C, Speas C, Espeland M, Hodges M, Knowler W, Ryan D for the Look AHEAD Research Group. Design and implementation of an automated publications tracking system in a clinical trial. Clinical Trials 2006;3:196.

149. Desiderio LM, Jaramillo SA, Felton D, Andrews LA, Espeland MA, Tan JC, Bryan NR, Perry J, Liu DF. A multi-institutional imaging network: application to Women’s Health Initiative Memory Study. Clinical Trials 2006;3:193.

150. Underhill HR, Crouse JR, Espeland MA, Chen H, Terry JG, Hatsukami TS, Saam T, Chu Baocheng, Takaya N, Tong R, Yarnykh V, Carr JJ, Ferguson M, Yuan C. Association of carotid wall features with coronary artery disease: a case-control high resolution magnetic resonance imaging study. Circulation 2006 (in press).

151. Henderson VW, Espeland MA, Hogan PE, Rapp SE, Stefanick MK, Wactawski-Wende J, Johnson KC, Wassertheil-Smoller S, Freeman R, Curb D. Prior use of hormone therapy and incident Alzheimer's disease in the Women's Health Initiative Memory Study. Annual meetings of the American Academy of Neurology, 2007.

152. Espeland MA, Miller ME, Gill TM, Guralnik J, Fielding R, Newman AB, Hsu FC, Walkup M, Pahor M. Using a pilot trial to evaluate potential primary outcomes measures: results from the Lifestyle Interventions for Elders (LIFE) Study Group. Annual meetings of the Society for Clinical Trials, Montreal, 2007.

153. Resnick SM, Espeland MA, Hirsch CH, Jaramillo SA, Murray AM, Ockene J, Stefanick ML, Davatzikos C. Effects of postmenopausal hormone therapy on regional brain volumes: The Women’s Health Initiative Memory Study – Magnetic Resonance Imaging Study (WHIMS-MRI). American Neurological Association, Chicago, 2008.

154. Atkinson HH, Williamson JD, Rapp SR, Lovato J, Sink KM, Absher JR, Gass M,

Henderson V, Johnson KC, Espeland MA. Grip strength predicts dementia in 75 to 80 year old women: the Women’s Health Initiative Memory Study (WHIMS). J Am Geriatr Soc 2008;56:S107.

155. Barad DH, Bevers TB, Coker LH, Espeland MA, Jaramillo SA, Limacher M, Lane DS, Rapp S, Maki P, Shumaker SA, et al. Relative effects of tamoxifen and raloxifene (CoSTAR) clinical trials. Reprod Sci 2008;15:309A.

156. Vestergaard S, Patel KV, Walkup MP, Pahor M, Marsh AP, Espeland MA, Studenski S, Gill TM, Church T, Guralnik JM. Stopping to rest during a 400-meter walk and incident mobility disability in older persons with functional limitations. Gerontological Society of America, 2008 Gerontologist 2008;48:198.

157. Espeland MA, Bryan NR, Coker LH, Manson J, Phillips LS, Rapp SR, Sarto GE, Stefanick ML, Wassertheil-Smoller S, Resnick SM. Influence of educational attainment and occupation on relationships that cognitive function has with MRI based neuropathology, mild cognitive impairment, and dementia: Results from the Women’s Health Initiative Memory Study. Alzheimer’s Disease International Conference on Alzheimer Disease, Chicago, 2008 Alzheimers Demet 2008;4:T672.

158. Feeney P, Robertson J, Yates T, Lane K, Mount D, Espeland M, Byington B, Wilmoth S, Bahnson J. Creating a common data set – merging baseline data from two ongoing trials: Look AHEAD and ACCORD. Clinical Trials 2008;5:418.

159. Marsh AP, Rejeski WJ, Espeland MA, Church T, Fielding R, Gill TM, Guralnik J, Miller MR, Newman AB, Pahor M, Vesteraard S. Predictors of risk for 400-m walk failure in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Gerontological Society

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of America, 2008 Gerontologist 2008;48:197-198.

160. Coker LH, Espeland M, Rapp SR, Legault C, Resnick S, Hogan P, Maggie D, Jaramillo S, Shumaker S. Postmenopausal Hormone Therapy and Cognitive Outcomes: The Women's Health Initiative Memory Study (WHIMS) for the IX International Aromatase Conference, Shanghai, Oct 2008.

161. Bushnell CA, Tindle HA, Espeland MA, Jaramillo SA, Kuller LH, Margolis KL, Mysiw WJ, Maldjian JA, Melhem ER, Resnick SM. Regional Brain and Ischemic Lesion Volumes in Women with Cognitive Impairment Following Exposure to Conjugated Equine Estrogen Therapies: The Women’s Health Initiative Memory Study—Magnetic Resonance Imaging (WHIMS-MRI). American Association of Neurology (2009 annual meetings).

162. Jaramillo SA, Amoroso R, Andrews LA, Barnes J, Davis P, Dobrosielski M, Dove R,

Felton D, King MD, Prescott A, Roberson W, Stark S, Espeland MA. Pilot Studies for Developing Clinical Trials of Cognitive and Behavioral Interventions: The Seniors Health and Activity Research Program (SHARP). Clinical Trials 2009;6(5):508.

163. Espeland MA, Feeney P, Fabricatore AB, Coday M, Bahnson J, Byington B, Phelan S, Wilmoth S, Knowler W, Hramiak I, Osei K, Sweeney ME, Mount D. Comparing results from clinical trials of pharmacologic and lifestyle interventions may be hampered by differences in study cohorts: Results from the Look AHEAD and ACCORD Trials, Annual meetings of the Society for Clinical Trials, 2009 Atlanta.

164. Espeland MA, Beavers D, Brunner RL, Coker LH, Dagenbach D, Gaussoin SA, Jennings JM, Rapp SR, Resnick SM, Simpson SL, Sink KM. Variability in Domain-Specific Cognitive Function and Incident Dementia: The Women’s Health Initiative Study of Cognitive Aging. The 2010 North Carolina Cognition Group Annual Meeting, Winston-Salem, NC.

165. Espeland MA. ALLHAT: Long-term outcomes of a drug treatment in high CHD risk hypertensive patients. Discussant. American Society of Hypertension 2010 meetings, New York.

166. Espeland MA. Look AHEAD: clinical impact of a large clinical trial. 2010 annual meetings of the German Diabetes Society, Stuttgart, Germany.

167. Klepin HD, Geiger AM, Costantino JP, Sink KM, Lawrence JA, Espeland MA. Association between domain-specific cognitive function and adherence to oral anti-cancer therapy: Results from Cognition in the Study of Tamoxifen and Raloxifene (Co-STAR). American Geriatrics Society, 2010.

168. Bertoni AG, Wagenknecht LE, Kitzman DW, Marcovina SM, Espeland MA. Impact of lifestyle intervention on brain natriuretic peptide in diabetes: The Look AHEAD Study. American Diabetes Association, 2010.

169. Shih RA, Bird CE, Eibner C, Espeland MA, Ghosh-Dastibar B, Jewell A, Margolis KL, Slaughter ME. Neighborhood socioeconomic status and cognitive function in the Women’s Health Initiative Memory Study (WHIMS) American Association for Geriatric Psychiatry, 2010.

170. Espeland MA, Rejeski WJ, Katula JA, Rapp SR, Gaussoin SA, Jennings JM, Legault C. Designing clinical trials to assess the effects of behavioral interventions on cognitive outcomes in seniors. Gerontological Society of America's 63rd Annual Scientific Meeting, New Orleans, 2010.

171. Espeland MA, Haan M, Yaffe K, Gaussoin SA, Resnick SA, Roussouw JE, Shumaker SA. Relationship of retinopathy to regional brain volumes and cognitive function. Gerontological Society of America's 63rd Annual Scientific Meeting, New Orleans, 2010.

172. Shih R, Ghosh-Dastidar B, Margolis KL, Slaughter ME, Jewell A, Bird CE, Eibner C,

Denburg NL, Ockene J, Messina CR, Espeland MA Neighborhood socioeconomic status

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and global cognitive function in the Women’s Health Initiative Memory Study. American Association of Geriatric Psychiatry, 2011.

173. Bertoni AG, Wagenknecht LE, Kitzman DW, Marcovina SA, Espeland MA. Association of glucose lowering and blood pressure medications with brain natriuretic peptide in diabetes: the Look AHEAD Study. American Heart Association Epidemiology Section, Atlanta, 2011.

174. Griffin L, King M, Perdue L, Erickson K, Ferguson E, Bahnson J, Lang W, Espeland M. Participant data entry for a web based data management system. Society for Clinical Trials, Vancouver, BC, Canada, 2011 (Clinical Trials 2011;8(4):445-446).

175. Perdue L, King M, Griffin L, Erickson K, Ferguson E, Bahnson J, Lang W, Espeland M. Data collection and storage for online screening prior to consent. Society for Clinical Trials, Vancouver, BC, Canada, 2011 (Clinical Trials 2011;8(4):446-447).

176. Gaussoin SA, Espeland MA, Absher J, Howard BV, Jones BM, Rapp SR. Ascertaining dementia related outcomes for deceased or proxy-dependent participants: An overview of the WHIMS Supplemental Case Ascertainment Protocol (SCAP). Society for Clinical Trials, Vancouver, BC, Canada, 2011 (Clinical Trials 2011;8(4):487-488).

177. Zhang P, Lawlor M, Davis D, Dotson K, Rushing J, Espeland M, Knowler W, Tsai A, Glick H. Costs associated with delivering a structured lifestyle intervention and diabetes education program in overweight and obese adults with type 2 diabetes: year 4 results from the Action for Health in Diabetes (Look AHEAD) Study. Diabetes 2011;60:A68..

178. Espeland MA, Miller ME, Goveas JS, Hogan PE, Coker LH, Williamson J, Naughton M, Resnick SM. Domain-specific cognitive function and fine motor speed in women 65 years and older with type 2 diabetes mellitus: results from the Women’s Health Initiative Study of Cognitive Aging. Diabetes 2011;60:A69-70.

179. Espeland MA, Neiberg RH, Bray GA, Faulconbridge L, Johnson KC, Kitabchi AE, Kitzman DW, Otto AD, Wing R. Patterns of weight changes over the first year of an intensive weight loss intervention are associated with longer term weight maintenance and changes in cardiovascular disease risk factors: Results from the Action for Health in Diabetes (Look AHEAD). Diabetes 2011;60:A516.

180. Espeland MA, Haan M, Klein BE, Casanova R, Gaussoin SA, Jackson RD, Millen AE, Resnick SM, Rossouw JE, Shumaker SA, Wallace R, Yaffe K. Relationship of retinopathy to regional brain volumes and cognitive function. American Diabetes Association Brain Symposium, Alexandria, VA, 2011.

181. Katula JA, Lucas A, Jennings JM, Legault C, Gaussoin S, Yamamoto K, Dagenbach D,

Sink K, Rapp S, Rejeski J, Espeland M. The role of executive function in 400 m walk performance: the Seniors Health and Activity Research Program Pilot. Ann Behav Med 2011;41(Suppl1):S113.

182. Shea MK, Nicklas BJ, Houston DK, Miller ME, Davis CC, Kitzman DW, Espeland MA, Appel LJ, Kritchevsky SB. The effect of intentional weight loss on total mortality in older adults: a pooled analysis of two randomized-controlled trials. Gerontologist 2011;51(Suppl1);518.

183. Espeland MA. Cognitive function data: resources, approaches, results and opportunities. Department of Biostatistical Sciences Research Seminar Series. Wake Forest School of Medicine, 2012.

184. Espeland MA. Action for Health in Diabetes: emerging results and future directions. Department of Public Health Sciences Research Seminar Series. Wake Forest School of Medicine, 2012.

185. Espeland MA. What’s new with WHIMS? Women’s Health Center of Excellence Research Seminar Series. Wake Forest School of Medicine, 2012.

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186. Curtis JM, Killean T, Bray GA, Cheskin LJ, Horton ES, Johnson KC, Jakicic KM, Pi-

Sunyer X, Regensteiner J, Ribisl P, Wagenknecht L, Espeland MA. Impact of CVD history and GXT abnormalities on weight loss and fitness gain. Diabetes 2012;61S(1):124.

187. Espeland MA, Bryan RN, Casanova R, Coker LH, Goveas JS, Hogan PE, Liu S, Masaki K, Resnick SM, Robinson J, Rossom R, Siddiqui MS, Yaffe K. Influence of type 2 diabetes mellitus on brain volumes and changes in brain volumes. Diabetes 2012;61S(1):A348.

188. Espeland MA, Shumaker SA, Resnick SR. The Women’s Health Initiative Memory Study of Younger Women (WHIMSY): Rationale, design, and preliminary data. Invited speaker, American Aging Association Conference on the Window of Opportunity for Estrogen and Progestin Intervention During Aging and Alzheimer’s Disease. Fort Worth, 2012.

189. Espeland MA, Castro CM, Jennings J, Katula J, Kerwin DR, Kramer A, Rushing J. Performance of a computer-based assessment of cognitive function in two cohorts of seniors. Gerontological Society of America annual meetings, San Diego, November, 2012.

190. Kostis WJ, Cabrera J, Hooper C, Whelton PK, Espeland MA, Cosgrove NM, Sedjro JE, Queng JQ, Deng Y, De Starcke C, Pyle M, Maruther N, Reyes I, Anderson CAM, Lie J, Kostis JB. Weight sensitivity in hypertension. American Heart Association, Los Angeles, November, 2012.

191. Crane MM, Tate DF, LaRose JG, Espeland M. Randomized comparison of messages for recruiting men into a weight gain prevention trial. Ann Behav Med 2012l43(Suppl 11):S191.

192. Tate DF, LaRose JG, Espeland M, Bahnson J, Ferguson E, Erickson KE, Perdue L, Wing RR. Recruitment of young adults for weight gain prevention. Ann Behav Med 2012;43(Suppl1):S240.

193. Welsh-Bohmer K, Romero H, Hayden K, Plassman D, Sano M, Espeland M, Craft S, Monsch A, Schneider LS, Chiang C, Haneline S, O’Neill J, Malhotra M, Brannan S, Burns DK, Roses A. Challenges in international clinical trials to delay early symptomatic Alzheimer’s disease. Alzheimer’s Association International Conference, Boston, 2013.

194. Espeland MA, Shumaker SA, Leng I, Manson JE, Brown CM, LeBlanc ES, Vaughan L, Robinson J, Rapp SR, Goveas JS, Lane D, Wactawski-Wende J, Stefanick ML, Li W, Resnick SM. Long term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50-54 years: results from the Women’s Health Initiative Memory Study of Younger Women (WHIMSY). Alzheimer’s Association International Conference, Boston, 2013.

195. Monsch AU, Sano M, Schneider LS, Craft S, Espeland MA, Welsh-Bohmer KA.

Operationalizing the clinical diagnosis of MCI due to Alzheimer’s disease. International College of Neuropsychopharmacology Annual Meetings, Jerusalem, 2013.

196. Espeland M, Brancati F, Evans M, Gregg E, Kahn S, Lewis CB, Pi-Sunyer X, Reboussin D, Yanivski S, Wing R. Design and primary findings of the Action for Health in Diabetes Trial. Annual meetings of the Gerontological Society of America, 2013.

197. Marx N, Rosenstock J, Kahn SE, Sinman B, Kastelein JJ, Lachin J, Espeland MA, Bluhmki E, mattheus M, Patel S, Johansen OE, Worle HJ. Baseline characteristics of patients enrolled in the cardiovascular outcome study of linagliptin versus glimepiride in patients with type 2 diabetes (CAROLINA). Annual meetings of the EASD, Barcelona, 2013.

198. Sink K, Corbett M, Dugan E, Espeland M, Hogan P, Rapp S, Vaughan L, Shumaker S. Prevalence and predictors of driving among cognitively impaired older adults: The

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Women’s Health Intiative Memory Study Epidemiology of Cognitive Health Outcomes. The Gerontological Society of America Annual Meeting, New Orleans, 2013.

199. Miller M, Walkup M, Barnes D, Johnson K, Lopez O, Williamson J, Pahor M, Espeland

M. Using external data to project the incidence of dementia in the LIFE cohort. The Gerontological Society of America Annual Meeting, New Orleans, 2013.

200. Espeland M, Brancati F, Evans M, Gregg E, Kahn S, Lewis C, Pi-Sunyer X, Wing R and the Look AHEAD Research Group. Design and primary findings of the Action for Health in Diabetes. The Gerontological Society of America Annual Meeting, New Orleans, 2013.

201. Kahn SE, Rosenstock J, Marx N, Zinman B, Kastelein JJ, Espeland M, Bluhmki E, Matheus M, Ryckaert B, Patel S, Johansen OE, Woerle H-J. Modulation of cardiovascular (CV) risk in type 2 diabetes (T2D) with DPP4-inhibitors (DPP4i): does timing of intervention and length of exposure play a role. Annual Meetings of the American Diabetes Association, San Francisco, 2014.

202. Espeland MA, Vaughan L, Romero H, Hayden K, Plassman B, Welsh-Bohmer K. Deriving an informed neurocomposite measure for delay of onset trials in mild cognitive impairment due to Alzheimer’s disease (MCI-AD). Annual meetings of the Alzheimer’s Association International Conference, Copenhagen, 2014.

203. Padula CB, Weitlauf J, Rosen AC, Reiber G, Naughton M, Rissling M, Hunt J, Li W,

Cochrane B, Goldstein M, Yaffe K., Espeland MA. Longitudinal cognitive trajectories of women veterans from the Women’s Health Initiative Memory Study. Abstract submitted for presentation at the meeting of International Neuropsychological Society, Denver, CO. (2105).

204. Goveas JS. Rapp S, Hogan P, Yaffe K, Manson JE, Tindle H, Resnick SM, Espeland

MA. Predictors of optimal cognitive aging in 80+ women: The Women’s Health Initiative Memory Study. 2014 Annual GSA meetings, Washington, DC.

205. Padula CB, Weitlauf J, Rosen AC, Reiber G, Naughton M, Rissling M, Hunt J, Li W,

Cochrane B, Goldstein M, Yaffe K, Espeland M. Longitudinal cognitive trajectories of women veterans from the Women’s Health Initiative Memory Study. Poster to be presented at the meeting of International Neuropsychological Society, Denver, CO (2015).

206. Nocera JR, Hire DG, Cook DR, McGregor K, Katula J, Rapp SR, Sink KM, Jennings J, Fielding RA, Reid K, Kramer A, Verghese J, King AC, Manini Tm, Buford TW, Anton S,

Nadkarni N, Espeland MA, Pahor M for the LIFE Study Research Group. Greater intensity and time of non-sedentary activity is associated with higher cognitive performance in sedentary older adults. Society for Neuroscience- Annual Meeting. Washington D.C. November 19, 2014.

207. Casanova R, Wang X, Reyes J, Akita Y, Serre M, Vizuete W. Chui C, Driscoll I, Resnick

S, Espeland M, Chen JC. Exposures to fine particulate air pollutants are associated with smaller brain volumes in older women: a voxel-based analysis. AAIC 2015 meetings, Washington, DC.

208. Hugenschmidt CE, Resnick SM, Brinton RD, Manson JE, Yaffe K, Vaughan AL, Craft S,

Edwards BJ, Casanova R, Masaki K, Espeland MA. Interactions of diabetes and postmenopausal hormone therapy on brain volumes: WHIMS. AAIC 2015 meetings, Washington, DC.

209. Espeland MA, Rapp SR, Manson JE, Goveas JS, Shumaker SA, Hayden KM, Weitlauf J, Gaussoin SA, Baker LD, Padula CB, Hou L, Resnick SR for the WHIMSY and WHIMS-ECHO Study Groups. Long term effects on cognitive trajectories of early versus late postmenopausal hormone therapy. AAIC 2016 meetings, Toronto.

210. Janssen J, van den Berg E, Zinman B, Espeland MA, Woerle HJ, Mattheus M,

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Johansen OE, Biessels GJ. Cardiovascular factors and cognition in patients with type 2 diabetes at elevated vascular risk: the CAROLINA cognition study. VASCOG 2016.

211. Espeland MA, Luchsinger JA, Baker LD, Neiberg R, Kahn SE, Arnold SE, Wing R, Blackburn G, Evans M, Hazuda H, Jeffery RW, Wilson VM, Rapp SR for the Look AHEAD Research Group. Long term lifestyle intervention, diabetes, obesity, and cognitive aging: results from the Action for Health in Diabetes (Look AHEAD) study group. 7th Annual Alliance for Healthy Aging Conference, Jacksonville, 2016.

212. Espeland MA, Crandall JP, Kritchevsky S, Crimmins EM, Grossardt B, Bahnson J, Miller ME, Justice JN, Barzilai N for the Targeting Aging with Metformin (TAME) Study Group. Designing Clinical Trials with Age-Related Multiple Morbidity Outcomes. Society for Clinical Trials 2017, Liverpool.

213. Espeland MA Long-Term Impact of a Lifestyle Intervention on Cognitive Outcomes among Individuals with Diabetes – Findings from Look AHEAD. Invited presentation: American Diabetes Association, 2017, San Diego.

214. Espeland MA, Erickson K, Neiberg RH, Jakicic JM, Wadden TA, Wing RR, Desiderio L, Erus G, Hsieh M-K, Davatzikos C, Maschak-Carey BJ, Laurienti PJ, Demos-McDermott K, Nasrallah I, Bryan RN for the Action for Health In Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) Ancillary Study Research Group. Brain and white matter hyperintensity volumes after ten years of random assignment to lifestyle intervention. Alzheimer’s Association International Conference, 2017, London.

215. Chen JC, Wang X, Casanova R, Serre ML, Vizuete W, Chui HC, Resnick SM, Espeland

MA. Neurotoxic Effects of Ambient Air Pollution on Brain Structure and Dementia Risk in Older Women. International Association of Geriatrics and Gerontology 2017, San Francisco.

216. Espeland MA, Erickson K, Neiberg RH,J akicic JM, Wadden TA, Wing RR, Desiderio L, Bryan RN for the Action for Health In Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) Ancillary Study Research Group. Brain volumes after random assignment to ten years of lifestyle intervention. International Association of Geriatrics and Gerontology 2017, San Francisco.

217. Davenport EM, Urban JE, Kelley ME, Jones DA, Wagner B, Espeland MA, Powers AK, Whitlow CT, Stitzel JD, Maldjian JA, “Subconcussive impacts in youth football correlate with meg mean default mode network.” American Society of Functional Neuroradiology 11th Annual Meeting, Portland, OR, October 2017.

Book Reviews

1. Statistical Analysis with Missing Data. By Roderick J. A. Little and Donald B. Rubin. American Journal of Sociology 94(3),156-158;1988.

Letters

1. Espeland MA, Hui SL. Response to "Algorithms versus models for analyzing data that contain misclassification errors, Ekholm A." Biometrics 1991;47:1177-1182.

2. Espeland MA, Rapp SR, Masaki KH. Response to Rozzini, et al. American Journal of Epidemiology 2005;162:295-296.

3. Wing RR, Wadden TA, Espeland MA. Adjustable gastric banding and conventional therapy for Type 2 diabetes. JAMA 2008;299:2146.

4. Rossom RC, Espeland MA, Manson JE, Dysken MW, Johnson KC, Lane SA, Leblanc ES, Lederle FA, Masaki KH, Margolis KL. Response to Annweiler and Beaughet. Journal

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of the American Geriatrics Society 2013;61:1050-1. PMID 23772745 5. Wing RR, Leahey T, Espeland M. Response to “Clustering effects in group-based

behavioral weight loss trials. Obesity 2014;17;1771.. PMID: 24820658. Papers in Review or Preparation 1. Katula JA, Jennings JM, Gaussoin SA, Lucas AR, Henley KY, Griffith E, Sink KM, Rapp

SR, Dagenbach D, Rejeski WJ, Legault C, Espeland MA. The relationships among executive functioning and changes in gait speed resulting from cognitive and physical activity training: the Seniors Health and Activity Research Program Pilot Trial (SHARP-P).

2. Chen JC, Espeland MA, Wang X, Pottala J, Robertson J, Casanova R, Cen S, He K, McArdle JJ, Allen NB, Naughton M. Geographical disparities in cognitive aging of older women: evidence from the Women’s Health Initiative.

3. Nocera JR, Hire DG, Cook DR, Katula K, Fielding RA, Kramer AF, Verghese J, Rapp SR, Sink KM, King AC, Manini TM, Buford TW, Anton S, Nadkarni N, Jennings J, Reid K,

Espeland MA, Gill TM, Pahor M. for the LIFE Study Research Group. Non-sedentary activity is associated with higher cognitive-executive performance in sedentary older adults

4. Driscoll I, Snively BM, Espeland MA, Shumaker SA, Rapp R, Goveas JS, Casanova RL, Wactawski-Wende J, Manson JE, Rossom R, Brooks J, Hernandez D, Singleton A, Resnick Susan M. A candidate gene study of risk for dementia and mild cognitive impairment in older, post-menopausal women: Results from the Women’s Health Initiative Memory Study (WHIMS).

5. Curtis JM, Killean TM, Bray GA, Cheskin LJ, Horton ES, Johnson KC, Jakicic JM, Pi-

Sunyer FX, Regensteiner JG, Ribisl PM, Wagenknecht L, Espeland MA and the Look AHEAD Research Group. The impact of an abnormal stress test or history of cardiovascular disease on subsequent weight loss or fitness improvement in the Look AHEAD trial.

6. Davenport EM, Urban J, Santago P, Moran R, Wagner B, Espeland MA, Vaughan CG, Gioia GA, Powers AK, Whitlow C, Stitzel J, Maldjian J. Season of high school football increases MEG low-frequency brain waves.

7. Urban JE, Kelley ME, Espeland MA, Miller LE, Jones DA, Davenport EM, Christopher T. Whitlow CT, Powers AK, Maldjian JA, Stitzel JD. Effects of anthropometric and environmental variables on biomechanical measures of head impact exposure in youth football players.

8. Elmore A, Harris WS, Mu L, Brady WE, Mares JA, Espeland MA, Robinson JG, Haan MN, Millen AE. Red blood cell membrane fatty acids and incident age-related macular degeneration in postmenopausal women.

9. Miller LE, Pinkerton E, Fabian K, Wu L, Espeland MA, Camarillo DB, Stitzel JD, Urban JE. Characterizing head impact exposure in youth female soccer with a custom-instrumented mouthguard.

10. Brinkley TE, Anderson A, Soliman EZ, Bertoni AG, Greenway F, Knowler WC, Glasser

SP, Horton ES, Espeland MA. Long-term effects of an intensive lifestyle intervention on electrocardiographic criteria for left ventricular hypertrophy: The Look AHEAD Trial.

Selected Cooperative Studies / Clinical Trials Experience

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1981-1983 Assistant Director, Statistical Coordinating Center, Cooperative Study of Sickle

Cell Disease (CSSCD) 1985-1986 Director, Biostatistical Core, Cariology Center Grant, Eastman Dental Center 1987-1995 Co-Principal Director, Coordinating Center, Postmenopausal Estrogen/Progestin

Intervention Study (PEPI) 1987-1994 Co-Investigator, Primary Statistician, Administrative Center, Asymptomatic

Carotid Artery Plaque Study (ACAPS) 1987-1994 Co-Investigator, Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS) 1988-1994 Co-Investigator, Efficacy and Safety of SQ 31,000 in Coronary Patients with

Asymptomatic Carotid Atherosclerosis (PLAC2) 1991-1997 Principal Investigator, Coordinating Center, Trial of Nonpharmacologic

Interventions in the Elderly (TONE) 1992-1994 Co-Investigator, Coordinating Center subcontract, Women's Health Initiative

(WHI) 1994-1998 Co-Principal Investigator, Postmenopausal Estrogen/Progestin Intervention

Continuation Study (PEPI 2) 1994-1999 Co-Investigator, PEPI Safety Follow-up Study 1994-1996 Co-Principal Investigator, Activity Counseling Trial (ACT) 1995-2004 Co-Principal Investigator, Women's Health Initiative Memory Study (WHIMS) 1996-2000 Co-Investigator, Cardiovascular Health Study Brachial Artery Substudy (CHS-BA) 1997-2003 Principal Investigator, Autoimmune Inner Ear Disease Trial (AIED) 1999-2008 Co-Principal Investigator, Women’s Health Initiative Study of Cognitive Aging (WHISCA) 1999- Principal Investigator, Action for Health in Diabetes (Look AHEAD) 1999-2001 Principal Investigator, Early Non-tidal Ventilation in VLBW Infants (NVSG) 1999-2001 Co-Investigator, Insulin Resistance and Atherosclerosis Study (IRAS) 2000-2007 Co-Investigator, Study of Tamoxifen and Raloxifene Cognition Study (CoSTAR) 2001-2005 Co-Investigator, Study to Examine Rates of Childhood Diabetes (SEARCH) 2001-2005 Co-Investigator, Type 1 Diabetes Genetics Consortium (T1DGC) 2003-2007 Co-Investigator, Lifestyle Interventions and Independence for Elders (LIFE) pilot study 2004-2007 Co-Principal Investigator, Women’s Health Initiative Memory Study – Magnetic Resonance Imaging (WHIMS-MRI) 2004-2011 Co-Principal Investigator, Women’s Health Initiative Memory Study Extension (WHIMS-Ext) 2006-2009 Co-Principal Investigator, Translating Research Into Prevention of Diabetes (TRIP-DM) Trial 2007-2010 Principal Investigator, Seniors Health and Activity Research Program pilot (SHARP-P) 2009-2011 Co-Principal Investigator, Women’s Health Initiative Memory Study – Magnetic Resonance Imaging 2 (WHIMS-MRI2) 2009-2011 Principal Investigator (subcontract): Omega-3 Fatty Acid Biomarkers and Cognitive Decline in the Women’s Health Initiative Memory Study 2009-2016 Co-Investigator, Women’s Health Initiative Memory Study of Younger Women (WHIMS-

Y) 2009-2016 Principal Investigator, Study of Novel Approaches to Prevention (SNAP) 2009-2016 Co-Principal Investigator, Look AHEAD Physical and Cognitive Function Ancillary Study 2009- Co-Principal Investigator, Lifestyle Interventions and Independence for Elders (LIFE) 2010- Co-Investigator, Women’s Health Initiative Southeastern Regional Center (WHISE) 2011- Co-Investigator, Women’s Health Initiative ECHO Extension 2011-2016 Principal Investigator, Look AHEAD Brain Magnetic Resonance Imaging Study

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2011-2016 Principal Investigator (subcontract), Social Disparities of Sleep Disturbance; Neighborhood and Brain Behavior 2011-2016 Principal Investigator, Supplement to the Look AHEAD Brain MRI Study 2013-2016 Principal Investigator (Subcontract): Environmental Determinants of Cognitive Aging in the Women’s Health Initiative Memory Study 2013- Co-Investigator: Beta-cell function and cognition in the Restoring Insulin Secretion (RISE) Study 2015- Co-Investigator, ENRGISE-VS: ENabling Reduction of low-Grade Inflammation in SEniors Vanguard Study 2016- Dual PI - COcoa Supplement and Multivitamin Outcomes MIND Study (COSMOS-MIND) 2016- Core Director, Wake Forest Alzheimer’s Disease Core Center 2016- Principal Investigator, Study of Novel Approaches to Prevention Extension (SNAP-E) 2016- Principal Investigator, Subcontract to Alzheimer’s Therapeutic Research Institute Service (selected) 1985-1986 Vice-President/President Elect, Local Chapter, American Statistical Association,

Rochester, New York 1987-1988 Reviewer, National Heart, Lung, and Blood Institute 1987-1988 Statistical Consultant to NHLBI/Sickle Cell Division 1988-1991 Associate Dean's Committee, Bowman Gray School of Medicine 1989 External Reviewer, Biostatistics Core of the Diabetes Research and Training

Program Indiana University Medical School, Indianapolis 1990 Reviewer, American Heart Association, North Carolina Affiliate 1990-1994 Data and Safety Monitoring Board Member, CSPS #344A 'Implantable Insulin

Pump Study (IIPS), Cooperative Studies Program, Veterans Administration 1991 Reviewer, United States-Israel Binational Science Foundation 1992-1997 Data and Safety Monitoring Board Member, 'Sites Testing Osteoporosis

Prevention/Intervention Treatments (STOP/IT) Trials', National Institute on Aging, NIH

1992-1993 Special Emphasis Panel, Demonstration and Research Grants, National Heart, Lung and Blood Institute

1992-1993 Reviewer, Cooperative Studies Program, Department of Veterans Affairs 1993 Curriculum Review Committee, Department of Public Health Sciences, Bowman

Gray School of Medicine 1993-1996 Grant Reviewer, National Institute for Dental Research 1993-1998 Executive Committee, Department of Public Health Sciences, Bowman Gray

School of Medicine 1994-1999 Data and Safety Monitoring Board, Stroke Prevention Trial (STOP), National

Heart, Lung and Blood Institute, NIH 1994-1995 Consultant, Canadian National Health Research, and Development Program 1995 Consultant, Division of AIDS, NIAID, NIH 1995-2011 External Advisory Committee, Epidemiology of Diabetes, Interventions and

Complications, National Institute of Diabetes and Digestive and Kidney Diseases, NIH

1995-2000 Data and Safety Monitoring Board, American Foundation for AIDS Research, New York

1995-1997 Data and Safety Monitoring Board, Effect of Norplant on Cardiovascular Risk in Young Women (CHARM), University of Tennessee at Memphis

1995-1997 QualChoice Advisory Committee, QualChoice of North Carolina, Winston-Salem,

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North Carolina 1996-1997 Committee on Faculty Research Productivity, Bowman Gray School of Medicine,

Winston-Salem, North Carolina 1997-1998 Program Planning Committee, Society For Clinical Trials, 1998 meetings 1997-1998 Program Chair, Biometrics Section, American Statistical Association 1997 Ad hoc reviewer, NIH Study Section 1997 Judge, Fifth Annual Resident Research Day, Bowman Gray School of Medicine 1997- External Advisory Committee, Jackson Heart Study, National Heart, Lung, and

Blood Institute 1988 Program Committee, Drug Institute of America 1998-2004 Data and Safety Monitoring Committee, Hip Core Decompression Trial, National

Heart, Lung, and Blood Institute 1998-1999 Chair, Technology Protocol Committee, The Women’s Health Center of

Excellence of Wake Forest University Baptist Medical Center 1998-2004 Data and Safety Monitoring Board, 18F-Fluorodeoxyglucose (FDG) - Positron

Emission Tomography (PET) Imaging in the Management of Patients with Solitary Pulmonary Nodules, VA Cooperative Studies Program

1998 Consultant, Winston-Salem Forsyth County Public Schools 1999-2000 Chair, Research Committee, The Women’s Health Center of Excellence of Wake Forest University Baptist Medical Center 1999 Consultant, Ad Hoc Review, NIDDK 2000-2001 Women’s Health Research Coalition, Society for Women’s Health Research 2001 Repository Oversight Committee, National Institute on Aging, NIH 2001-2005 Data and Safety Monitoring Committee, A Comparison of Language Intervention

Programs, National Institute of Deafness and Communication Disorders, NIH 2001-2004 Research Advisory Committee, Wake Forest University School of Medicine 2001-2007 Data and Safety Monitoring Board, "Trochanteric Padding to Prevent Hip Fractures National Institute on Aging, NIH 2002-2005 Scientific Advisory Board, Cardiovascular Institute of New Jersey, University of Medicine and Dentistry of New Jersey / Robert Wood Johnson Medical School 2002 Ad hoc grant review, National Institute of Diabetes and Digestive and Kidney

Diseases 2002-2005 Board of Directors (elected position), Society for Clinical Trials 2002-2015 Data and Safety Monitoring Board, Exploratory Studies of Sustained Caloric Restriction, National Institute on Aging 2002-2007 Data and Safety Monitoring Board Chair, Weight Management Skills in African-American Outpatients, University of Pennsylvania 2002-2011 Data and Safety Monitoring Board, Studies to Treat of Prevent Pediatric Type 2 Diabetes (STOPP-T2D), National Institute of Diabetes and Digestive and Kidney Diseases, NIH 2003-2004 Friedberg Campus Oversight Committee, Wake Forest University 2003 Ephedra Working Group, Office of Dietary Supplements, National Institutes of Health 2003 Society for Clinical Trials Workshop Organizer and Presenter 2003 Consultant, Center for Food Safety and Applied Nutrition, US Food and Drug Administration 2003-2009 Society for Clinical Trials Website Oversight Committee (Chair 2004-9) 2004-2010 Board of Directors, SciWorks Science Museum, Winston-Salem, NC 2004- Data and Safety Monitoring Board, Islet Transplantation Study, National Institute

52

of Diabetes and Digestive and Kidney Diseases, NIH 2005 TrialNet Advisory Board, National Institute of Diabetes and Digestive and Kidney Diseases, NIH 2005 Academic/R&D Project Team, Advisory Committee for Biotechnology in the Piedmont 2005 Ad hoc grant review, Cancer Research UK 2006-2011 Chair, Data and Safety Monitoring Board, Targeting Inflammation using Salsalate for Type 2 diabetes (TINSAL-T2D), NIDDK 2006-2007 LCME Self Study Task Force Subcommittee - Educational Resources, Wake Forest University School of Medicine 2006 Invited Speaker: Anemia in Elderly: Clinical Trials Opportunities Advisory Workshop, NIA 2006-2011 Chair, Data and Safety Monitoring Board, Slow the Adverse Vascular Effects of Excess Weight (SAVE) 2006 Advisory Committee Site Visit, University of South Carolina Arnold School of Public Health 2007 Invited Speaker, NIA Task Force on Frailty and Intervention Therapies 2007 Invited Speaker, Hormones, Cognitive Function and Dementia, Loughborough University 2007-2008 Reviewer, Alzheimer’s Association 2007 External Site Visitor, TrialNet, National Institute of Diabetes and Digestive and Kidney Diseases, NIH 2007-2008 Transition Committee, Society for Clinical Trials 2007-2010 Secretary, Board of Directors, Sciworks Science Museum, Winston-Salem, NC 2007-2008 Faculty, Physical Activity and Public Health Postgraduate Course on Research Directions and Strategies, Centers for Disease Control and Prevention, DHHS 2008-2011 Chair, Data and Safety Monitoring Committee, Way To Health Clinical Trial, NHLBI 2009 Nominating Committee, Society For Clinical Trials 2009-2012 Data and Safety Monitoring Board, Multi-component Intervention for Reducing The Rate of Pneumonia, NIA 2009-2012 Faculty Mentoring Committee, Wake Forest University Health Sciences 2009 Research Strategic Planning Committee, Wake Forest University Health Sciences 2009,2011 NIH/CSR Alzheimer’s Disease Clinical Trials Special Emphasis Panel 2009- Data and Safety Monitoring Board: Vitamin D and Omega-3 Trial (VITAL), NCI/NHLBI 2010-2013 WFUSM Research Awards Day Committee 2010-6 Chair, Data and Safety Monitoring Board, Reducing Cardiovascular Disease Risk Through Treatment of Obstructive Sleep Apnea, NHLBI 2011-2014 Chair, Women’s Health Initiative Clinical Trials Working Group 2011 Reviewer, Special Emphasis Panel, NIA 2011-2016 Chair, Data and Safety Monitoring Board, Acupuncture in Menopause (AIM) NCCAM 2011- Data and Safety Monitoring Board, Hydroxyurea for the Prevention of Brain Injury of Sickle Cell Disease (NHLBI) 2011 Diabetes, Cognition, and Metabolism Working Group, Wake Forest School of Medicine 2012-16 Clinical Trials Advisory Panel, NIA

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2012 Committee Member, WFSM Faculty Retention Committee 2012 Expert Panel Member, NIA Workshop on Effects of Modulating Inflammatory Signals on Aging-Related Outcomes: Opportunities for Human Prevention Studies 2012 Panelist: ENAR Biometrics Society Workshop for Junior Researchers 2012-13 Panelist: NIH Consensus Development Conference: Diagnosing Gestational Diabetes Mellitus 2012 CEO Search Committee, SciWorks Nature and Science Museum 2013 Panelist: Special Statutory Funding Program for Type 1 Diabetes Research, NIDDK 2013 Workshop Panelist: Caloric Restriction Studies in Humans: Future Research Directions, NIA 2013-6 Data and Safety Monitoring Board: Metformin Therapy for Overweight Adolescents with Type 1 Diabetes, NIDDK 2013- Cognitive Aging and Memory Clinical Translational Research Program Advisory Board, Institute on Aging, University of Florida 2014 NCI Breast Cancer Steering Committee Clinical Trial Planning Meeting: Lifestyle Intervention for Improving Disease-Free Survival in Early Stage Invasive Breast

Cancer, Rockville 2014 External Evaluation Committee for the Trial to Reduce the Incidence of Type 1 Diabetes in the Genetically at Risk (TIGR), NIDDK, Bethesda 2013-6 Chair, Society for Clinical Trials Fellows Committee 2015 Workshop on Research Supported by Special Statutory Funding Program for Type 1 Diabetes Research, NIDDK 2015 Panelist: Workshop for Junior Researchers in Biostatistics, International Biometrics Society’s Eastern North American Region (ENAR) Annual Meetings 2015 Panelist: Gender Vulnerability to Alzheimer’s Disease Think Tank, Alzheimer’s Association 2015-17 National Academy of Sciences Committee for Decreasing the Risk of Developing Alzheimer’s-Type Dementia, Mild Cognitive Impairment, and Age-Related Cognitive Impairment 2015,16,17 Abstract Reviewer, 2016 Annual Meetings of the American Diabetes Association 2016 Scientific Advisory Board, Health Span – Biology of Human Ageing Program, Ministry of Health, Singapore 2016,17 Abstract Reviewer, 2017 IAGG World Congress of Gerontology and Geriatrics 2017 Grant Reviewer, UK Alzheimer’s Research 2017 Grant Reviewer, Leenaards Foundation, Switzerland 2017 Invited Panelist, NIA DGG Workshop: Opportunities for Trials on Effects of Statins in Primary Prevention in Older Adults 2017 Invited Panelist, NIA DGCG Workshop: Nutritional Interventions to Promote

Healthy Aging Industry 1994-1997 Advisory Data Review Board, Cato Research Ltd 1994-1997 Data and Safety Monitoring Committee, Merck Research Laboratories 2001-2007 Consultant, Digestive Care, Inc. 2002-2003 Consultant, Organon Pharmaceuticals 2002-2004 Data and Safety Monitoring Board, Wyeth Research 2002-2005 Data and Safety Monitoring Board, Wyeth-Ayerst Pharmaceuticals

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2003 Advisory Board, Johnson and Johnson Pharmaceutical Research & Development 2003 Consultant, Sankyo Pharma Development 2004 Consultant, Sanofi-Synthelabo 2004-2008 Data and Safety Monitoring Board, INO Therapeutics 2006-2007 Consultant, Schering-Plough 2007-2012 Data and Safety Monitoring Board, BTG International 2008 Advisory Board. Bristol-Meyers Squibb 2011-2012 Advisory Panel, Takeda Global Research and Development 2011-2015 Data and Safety Monitoring Board, KOWA Research Institute, Inc 2012-2016 Data and Safety Monitoring Board, Terumo Medical Corporation 2013-2015 Neuropsychiatric Advisory Panel, Boehringer-Ingelheim Pharmaceuticals 2014- Consultant, Takeda Global Research and Development Membership in Professional Organizations Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment (current) 2007-2008: Reviewer American Academy of Neurology (current) American Association for the Advancement of Science (since 2002) American Diabetes Association (current) American Heart Association (past) American Statistical Association (current) 1985-1986: Vice-President/President Elect, Local Chapter, Rochester, New York 1997-1998: Program Chair, Biometrics Section International Association for Dental Research (past) Society for Clinical Trials (current) 1997-1998: Program Planning Committee

2002-2005: Board of Directors 2004-2009: Website Oversight Committee 2013-2014: Fellows Committee

2014-2016: Chair, Fellows Committee Editorial Boards 1992-2000 Archives of Family Medicine 2012- Journal of Gerontology Medical Sciences: Statistical Editor Journal Referee American Journal of Epidemiology; American Journal of Managed Care; American Journal of Preventive Medicine; American Journal of Public Health; Annals of Internal Medicine; Applied Cognitive Psychology; Archives of Family Medicine; Arteriosclerosis, Thrombosis, and Vascular Biology; Biometrics; Biometrika; Biostatistics; Circulation; Clinical Trials; Coronary Artery Disease; Controlled Clinical Trials; Diabetes Care; Drugs and Aging; Epidemiology Reviews; Gynecologic Oncology; Journal of the American Medical Association; Journal of the American Geriatrics Society; Journal of Clinical Epidemiology; Climacteric; Journal of Computational Statistics and Data Analysis; Journal of Computational and Graphical Statistics; Journal of Epidemiology and Community Health; Journal of the American Statistical Association; Journal of Gerontology; Journal of Thoracic and Cardiovascular Surgery; Journal of the American Geriatrics Society; Neurobiology of Aging; Obesity; Obesity Research; Statistics Sweden; Stroke; Transactions of the American Fisheries; Technometrics

55

Students PhD Committee: James Pottala, PhD, University of South Dakota Currently Senior Biostatistician, PPD MS Dissertation Advisor: Jeffery Carr, MD, MS

Cornelius Vanderbilt Professor of Radiology and Radiological Sciences and Professor of Biomedical Informatics and Cardiovascular Medicine.

William Evans, MD, MS Private Practice, Concord, NC

Formal Mentoring Diversity Supplements: David Mount, PhD

Assistant Professor of Medicine Wake Forest School of Medicine

Ramon Casanova, PhD Associate Professor of Public Health Sciences Wake Forest School of Medicine K-awards: Ralph D’Agostino, PhD Professor of Public Health Sciences Wake Forest School of Medicine

Kylie Kavanagh, DVM Associate Professor of Comparative Medicine Wake Forest School of Medicine

Michael Cartwright, MD Associate Professor of Neurology Wake Forest School of Medicine Sean Simpson, PhD Associate Professor of Public Health Sciences Wake Forest School of Medicine Formal Committees: Jillian Urban Hobson, PhD Assistant Professor of Biomedical Engineering Wake Forest School of Medicine

A. Leslie Vaughan, PhD Private Consultant