CURRICULUM VITAE Arthur S. Edison,...

Edison, A. S., page 1

Updated: June 2015

CURRICULUM VITAE Arthur S. Edison, Ph.D.

Effective August 14, 2015 Professor and GRA Eminent Scholar Departments of Genetics and Biochemistry & Molecular Biology Complex Carbohydrate Research Center 315 Riverbend Road University of Georgia Athens, GA 30602 Web: http://edison.ccrc.uga.edu Email: [email protected] Phone:

Personal

Born April 18, 1960 in Salt Lake City, Utah Married (Katherine Edison), 2 daughters USA citizen

Education

St. John’s College, Santa Fe, NM no degree 1979-81 Liberal Arts University of Utah; Salt Lake City B.S. 1986-89 Chemistry University of Wisconsin (Madison) Ph.D. 1989-93 Biophysics

John Markley and Frank Weinhold, co-advisors University of Wisconsin (Madison) Postdoctoral 1993-96 Zoology

Antony O. W. Stretton, Postdoctoral advisor Positions Held

2015-Present Professor and GRA Eminent Scholar, University of Georgia 2013-2015: Director of the Southeast Center for Integrated Metabolomics 2012-2013: Associate Laboratory Director, NHMFL 2011-2013: Co-chair of the NHMFL Science Council 2010-2015: Professor, Biochemistry & Molecular Biology, University of Florida 2008-2012: Director of Chemistry & Biology, National High Magnetic Field Laboratory 2007-2013: Co-Principal Investigator of the National High Magnetic Field Laboratory 2005-2015: Faculty mentor in the UF HHMI Science for Life Program for undergraduate

students 2005-2015: Affiliate member of the Department of Biomedical Engineering, University of Florida 2003-2015: Faculty mentor in the UF Beckman Scholar Program for undergraduate students 2002-2010: Associate Professor (with tenure), Biochemistry & Molecular Biology, University of

Florida College of Medicine 2001-2008: Director, Advanced Magnetic Resonance Imaging and Spectroscopy (AMRIS)

facility of the McKnight Brain Institute.


1996-2002: Assistant Professor, Biochemistry & Molecular Biology, University of Florida College of Medicine

1996-2015: Member of the McKnight Brain Institute of the University of Florida 1996-2015: Member of the National High Magnetic Field Laboratory

Honors and Awards

2014 College of Medicine Exemplary Teachers Award 2014 Winner of the NIH Common Fund Commemoration Video Contest:

(http://directorsblog.nih.gov/2014/08/14/cool-videos-metabolomics/) 2013 College of Medicine Exemplary Teachers Award 2012 International Educator of the Year, UF College of Medicine 2012 College of Medicine Exemplary Teachers Award 2012-14 University of Florida Research Foundation Professor 2012-now Fulbright Specialist grant at National University of Buenos Aires, Argentina to teach

NMR and metabolomics for 1 month to students and faculty. A second trip to another country is planned with the award.

2009 Karcher Lecture, University of Oklahoma, Department of Chemistry & Biochemistry for accomplishments in small-molecule NMR solutions to problems in the field of natural products (Seminar Sept 24, 2009).

2009 First Place, Multimedia category for “Worm Belt”: 17th International C. elegans meeting Art Show.

2008-2011 Founder and head of the weekly Pineridge after school Science Club for underprivileged children.

2007 Jack L. Beal award for best paper in Journal of Natural Products 2007 Journal of Natural Products 2007 “Hot Article” 2003 Volunteer of the year, Prairie View Elementary School: Science Club 2000-2003 Founder and head of the weekly Prairie View Elementary School Science Club for

underprivileged children. 1999 NSF CAREER award 1997 Robert J. Boucek, M.D. Research Award for research grant with highest merit rating:

American Heart Association, Florida Affiliate 1993-1996 Fellow of the Jane Coffin Childs Memorial Fund for Medical Research 1989-1993 National Institutes of Health Training Grant in Molecular Biophysics 1989 American Institute of Chemists Award 1989 Phi Beta Kappa, Summa cum laude, University of Utah

Committee and Advisory Board Memberships

2015-Present BMRB Advisory Board (4 years) 2012-Present MRC-NIHR Phenome Centre – International Scientific Advisory Board (3-5 years) 2010-2013 UF Graduate Council 2009-2014 Co-Chair, Science Council, NHMFL 2009-2012 Chair, Search Committee for NHMFL Chief Scientist 2008-2010 UF Biomedical Engineering Faculty Search Committee 2006-2007 UF Biomedical Engineering Endowed Chair Search Committee 2006-2007 UF Department of Neuroscience Chair Search Committee 2005-2007 UF Biomedical Engineering Faculty Search Committee 2004-2005 Advisory Committee for the McKnight Brain Institute 2003-2007 Research Advisory Committee for University of Florida College of Medicine 2001-2015 Executive Committee National High Magnetic Field Laboratory


2000 Committee member of “Mathematics curriculum for Health & Life Science Students” sponsored by the Mathematical Association of America, Virginia Commonwealth University.

1996-2000 Graduate Recruiting and Admissions Committee for UF College of Medicine Editorial Board

Current Metabolomics Manuscript Reviewer

Biochemistry, Journal of the American Chemical Society, Nature, Journal of Biomolecular NMR, Biophysical Journal, Peptide and Protein Letters, FEBS, European Journal of Biochemistry, Journal of Magnetic Resonance, Journal of Molecular Biology, Analytical Chemistry, Nature Medicine, ACS Chemical Biology, PNAS, Science, Nature Protocols

Guest Editor PNAS

Wilson, D. M., Hurd, R. E., Keshari, K., Van Criekinge, M., Chen, A. P., Nelson, S. J., Vigneron, D. B., and Kurhanewicz, J. (2009) Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride, Proc Natl Acad Sci U S A 106, 5503-5507.

Grant Reviewer

Reviewer for NIH Transformative Research Awards (2014): ZRG1 BCMB-A 51R Member Special NIH Emphasis Panel/Scientific Review Group 2013/10 ZDC1 SRB-Y (52) Member Council for International Exchange of Scholars (CIES) Fulbright Specialist Chemistry

education peer reviewer, 2013-14 Wellcome Trust guest reviewer (2013) Member of NIH ZRG1 BST-P (50) “Technology development for metabolomics” panel (2012) National Institutes of Health, ZRG1 SBIB-V (58) R (Stage 1 Reviewer, 2009) National Institutes of Health, ZRG1 MOSS-C (58) R (Stage 1 Reviewer, 2009) National Institutes of Health, NCRR shared instrumentation grants (2005) American Heart Association (Southeast Affiliate), regular panel member (2004-2007) National Science Foundation, ad hoc (2006-Present) Royal Society of New Zealand, ad hoc Science Foundation of Ireland, ad hoc Human Frontier Science Program, ad hoc

Conference/Workshop Chair

2002 Southeast Magnetic Resonance Conference, Gainesville FL UF Workshop on Metabolomics (June 28 – July 1, 2010, Gainesville FL) UF Workshop on Metabolomics (June 4 – 7, 2012, Gainesville FL)

UF Workshop on Metabolomics (May 20-23, 2014, Gainesville FL) UF Workshop on Metabolomics (May 11-14, 2015, Gainesville FL)


Society Memberships

American Chemical Society, 1996-Present International Metabolomics Society, 2009-Present AAAS, 1993-2005 and 2015-Present

Major Administrative Responsibilities

2013-2015 Director of the Southeast Center for Integrated Metabolomics (SECIM): I was the communicating PI for the NIH Common Fund grant to support SECIM and am the Director of the new center, which was established in October, 2013. SECIM has 6 cores and offers mass spectrometry and NMR metabolomics services to users. A bioinformatics core develops tools for analysis.

2012-2013 Associate Laboratory Director, NHMFL: As ALD, I was the primary liaison between

the University of Florida upper administration, UF NHMFL user programs, and the NHMFL Director. I was responsible for coordinating NHMFL efforts at UF and for representing chemistry & biology in weekly ALD meetings with the NHMFL Director.

2008-2012 Director of Chemistry & Biology, NHMFL: As DCB, I advised the NHMFL Director

on NHMFL chem/bio activities, work with funding agencies (primarily NSF and NIH) to identify new opportunities for the NHMFL to increase its programs in chemistry and biology. I promoted the NHMFL chem/bio activities to universities and other national laboratories around the world. I helped to identify emerging new areas in chem/bio in which the NHMFL can make a substantial technical contribution and then organize efforts to develop the new technology.

2001-2008 AMRIS Director: I directly supervised between 8 and 12 full-time employees,

oversaw the operations of a facility with 7 magnetic resonance instruments with capabilities from small molecule NMR to human MRI research, managed an annual budget of about $1,000,000, and facilitated interactions with over 100 users from around the world. AMRIS is the biological magnetic resonance user facility for the NSF National High Magnetic Field Laboratory (Florida State University, University of Florida, and Los Alamos National Laboratory).

Teaching

2012 “Introduction to NMR, metabolomics, and natural products” 40 hours of lecture/discussion at the University of Buenos Aires. This was funded through a Fulbright Specialist grant.

2010-2015 BCH 6206: Advanced metabolism. I teach 4 lectures covering metabolomics. 2007-2015 GMS 6001: Fundamentals of Biomedical Science. I am course coordinator for the

biochemistry and molecular biology section. Duties include coordinating 34 lectures, 4 discussion sections, 2 grand round lectures, and 4 computer-based learning exercises. I teach the first 6 lectures of the class and am responsible for all other content organization and 2 final exams.

1997-2015 BCH 6745: Biomolecular NMR (15 lectures). This is a short class to introduce

graduate students to the basic theory and applications of biological NMR. Lecture


notes are distributed on my web site and widely used by lecturers and students around the world. This is jointly taught with Prof. Joanna Long.

2002-2015 BCH 6745L: Laboratory class to accompany BCH 6745. We teach five 3-hour labs

on data collection, processing, and analysis. Students receive formal training on AMRIS instruments and apply principles taught in the lectures. This is jointly taught with Prof. Joanna Long.

1997-2015 BCH 6740: Structural Biochemistry. This is generally for first year graduate

students, and we cover structural biology, biophysical techniques, and enzyme kinetics. I teach three introductory lectures in biomolecular NMR.

2001-2012 BMS 6204: Clinical Correlation Discussion Groups. I am a basic scientist in clinical

correlations, discussion-based classes for first year medical students to learn about the biochemical basis of disease (10 discussion sections each year). The entire medical school curriculum was changed last year, and this class was eliminated.

1997-2008 BCH 6877: “Structural Biology and Molecular Biophysics” student journal club: I

was the organizer and founder of this weekly interdisciplinary journal club for graduate students from the UF College of Medicine, Physics, and Chemistry.

1997-2008 Guest lecturer for graduate courses in ligand binding, introduction to biomedical

research, and computers in biology (2-3 lectures each year). 1998-2014 Guest lecturer for summer high-school students and teachers who come to UF for

science experience. 1993-1996 Founder and organizer of the weekly University of Wisconsin-Madison “Evolution

Reading Group”. This was a collection of students, postdocs, and faculty members from genetics, zoology, biochemistry, and history of science. We read Darwin’s “Origin of Species” and several other major works in evolution.

Students Trained

Postdoctoral Fellows: 2015: Dr. Chaevien Clendinen, Ph.D. Biomedical Sciences, University of Florida 2013-Present: Dr. Fariba Tayari, Ph.D. chemistry Purdue University. 2012-2014: Dr. Caroline Williams, Ph.D. (co-mentored with Prof. Dan Hahn). Currently an Assistant Professor at University of California, Berkeley. 2009-2012: Dr. Tatsuji Chuman, Ph.D. chemistry, University of Tokyo 2006-2010: Dr. Aaron Dossey, Ph.D. IDP, University of Florida. Founder and CEO of “All Things

Bugs” 2006-2008: Dr. Fatma Kaplan, Ph.D. plant pathology, University of Florida. Currently an

Adjunct lecturer and self employed consultant.


2003-2004: Dr. Yu Li, Ph.D. electrical engineering University of Illinois. Dr. Li designs novel NMR probes for small sample detection. Currently a faculty member at the Cincinnati Children’s Hospital.

2000-2003: Dr. Steve Thomas, Ph.D. physics University of Florida. Dr. Thomas is currently a

research scientist at the Naval Research Laboratory. 1996-2008: Dr. Cherian Zachariah, Ph.D. Loyola University. Dr. Zachariah is a biochemist

who started as a postdoctoral scientist (5 years) in my lab and became a Assistant Scientist managing the protein expression and molecular biology efforts of my group.

Graduate Students: 2013-Present: Jacquelyn Walejko, Ph.D. candidate IDP. 2012-2015: Vijaykumar Ramaswamy, Ph.D. 2012-Present: Brittany Lee, Ph.D. candidate IDP (co-mentor with Dr. Glenn Walter) 2010-2014: Greg Stupp, Ph.D. (IDP) “METABOLOMICS AS A TOOL FOR UNDERSTANDING

STRESS RESPONSES IN CAENORHABDITIS ELEGANS”, Currently a postdoctoral associate at Scripps Research Institute, La Jolla, CA

2010-2014: Chaevien Clendinen, Ph.D. (IDP) “DEVELOPMENT OF 13C-BASED

METABOLOMICS USING 13C NUCLEAR MAGNETIC RESONANCE AND MASS SPECTROMETRY”, Currently a postdoctoral associate with Facundo Fernandez at Georgia Tech.

2009-2011: Vijaykumar Ramaswamy, M.S. Biomedical Engineering. 2005-2009: Heather Cornnell, Ph.D. (Biomedical Engineering, co-supervised with Dr. Glenn

Walter, Physiology and Functional Genomics), “Optimization of Contrast Agents for High Magnetic Fields”. Currently a research scientist at Florida Hospital, Orlando.

2002-2008: Iman Al-Naggar, Ph.D. (co-supervised with Dr. Michael Bubb, Medicine)

“Structure/function of MARCKS”. Currently a secondary school science teacher. 2001-2008: Omjoy Ganesh, Ph.D. (co-supervised with Dr. Steve Hagen, Physics) “Folding and

binding of IA3, a potent protein inhibitor of yeast proteinase A”. Currently a pharmacist.

2001-2006: Aaron Dossey, Ph.D. “Chemical Biodiversity and Signaling: Detailed Analysis of

FMRFamide-like Neuropeptides and Other Natural Products by NMR and Bioinformatics.” Founder and CEO of “All Things Bugs”

1997-2003: Terry Green, Ph.D. (co-supervised with Dr. Ben Dunn, Biochemistry) “Structure-function studies of IA-3, an inhibitor of yeast proteinase A.” Currently working in an environmental industry.


1999-2002: Alexis Harrison, M.S. (co-supervised with Dr. Michael Bubb, Medicine) “Actin-binding properties of MARCKS”. Currently a medical doctor.

1997-2002: Ramanan Thirumoorthy, Ph.D. (co-supervised with Dr. Nigel Richards, Chemistry)

“Structure-function studies of AGRP-derived peptides”. 1997-2002: Matthew Carrigan, Ph.D. (co-supervised with Dr. Steve Benner, Chemistry)

“Evolutionary and functional analysis of group II introns and spliceosomal UsnRNAs.” Currently a research scientist at the Westheimer Institute for Science and Technology

1996-2002: James Leif Smith, Ph.D. (co-supervised with Dr. Jeff Hillman, Oral Biology) “Structure

and function of mutacin 1140.” Currently an associate professor at Texas A&M. Undergraduate Students Trained:

2014-2015 Dawit Woldegiorgis 2013-Present Francesca Ponce, Beckman Scholar 2012-2014 Wei Li, University Scholar awardee (medical school) 2012 Keiko Cooley (Claflin University summer REU) 2012 Justin Mincey (Bethune Cookman summer REU) 2012-2012 Daniel Su 2012-2013 Christine Ho, HHMI Science for Life awardee 2011-2012 Alyssa M Bagadion 2010-2012 Karim Kahn (medical school) 2009-2011 Abdulrahman Zeinomar (currently a pharmD student) 2009-2011 Michael Garrote 2006-2010 Steve Robinette, HHMI Science for Life and Provost Scholar, Marshall Scholarship

recipient, Ph.D. from Imperial College (currently a consultant with McKinsey & Company)

2007-2011 Denny Agana (currently a MS student) 2008-2010 Hasan Rasheed (currently a medical student at UF) 2009-2010 Jessica Antonio (currently a nursing student) 2009-2013 Circe Lassegue, HHMI Science for Life Scholar 2009 Bo Park 2009 Amanda Gostigian 2007-2009 Ethan Wilson, HHMI Science for Life Scholar (medical school) 2007-2008 Sunny Kar 2007-2008 Elbert Vaca (current a medical student at Johns Hopkins) 2007-2008 Alex Brasher (grad student at Scripps-FL) 2006-2007 Maria Laura Amaya. (medical school) 2006-2007 Gloria Tavera, medical school 2006-2007 Cynthia Nwachukwu 2005-2006 Nathan O’Brien (medical school) 2004-2007 Michael Stadler, Beckman Scholar. Grad student Stanford University. 2003-2004 Romina Hennig, McNair Minority Scholar, vet school 2001-2004 Ramadan Ajredini. Current my lab manager 2003-2004 Tom Bemben. Medical School 2003-2004 Jill Adox. Medical School 2002-2003 Kalyani Marathe. Medical School 2002-2003 Frank Rauci. Medical School 2001-2003 Jay Hall


2001-2003 Jennifer Jeung. Medical doctor. 2000-2001 Eric Shen (high school student). (UF grad school) 2000-2002 Jonathan Shin. 1999-2001 Kyle Perry. M.D., Medical doctor. 1998-2001 Christina Norris. (grad school) 1997-1999 Elena Rodriguez. Ph.D. from UC-Berkeley 1997-2000 Vijay Antharam. Ph.D. from UF. Currently a postdoc.

Visiting Scholars in Edison Laboratory

May, 2015 to May, 2015: Dr. Ricardo Borges, Instituto de Pesquisas de Produtos Naturais Walter Mors – IPPN, Universidade Federal do Rio de Janeiro – UFRJ

s December, 2014 to March, 2015: Dr. Martín Arán, Fundación Instituto Leloir, Patricias Argentinas

435, CABA, Argentina. November, 2014 to Nov, 2015: Prof. Zhenyu Li, Modern Research Center for Traditional Chinese

Medicine of Shanxi University, Taiyuan, Wucheng 92, 03006, China. March, 2013 to Feb 2014: Mr. Rafael Teixeira Freire, visiting graduate student from Universidade

Estadual Paulista "Júlio de Mesquita Filho" UNESP, Instituto de Química - Araraquara - SP – BRASIL.

January, 2012 to December, 2012: Prof. Ting Liu, visiting scholar from the Beijing Academy of

Agricultural and Forestry Science. March, 2009 to March, 2010: Ian Castro-Gamboa, Ph.D., Assistant Professor, Department of Organic

Chemistry, São Paulo State University – UNESP – Araraquara – SP – Brazil. Summer, 2009: Mr. Christian Pasquel, Undergraduate physics student from Pontificia Universidad

Católica Del Perú (PUCP), Lima, Peru Summers, 2007/2008: Ms. Rathika Nimalendran, Undergraduate neuroscience student from

Wellesley College. Edison subsequently arranged a 1-year internship for Rathika at Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru.

Recent Collaborators

Jeremy Nicholson, Ph.D., Imperial College London Elaine Holmes, Ph.D., Imperial College London Timothy Ebbels, Ph.D., Imperial College London Burton Singer, Ph.D., Emerging Pathogens Institute, UF Glenn Walter, Ph.D., Department of Physiology, UF Chris Beecher, Ph.D., IROA Technologies/UF. Rick Yost, Ph.D., Department of Chemistry, UF Tim Garrett, Ph.D., Department of Pathology, UF Charles Baer, Ph.D., Department of Biology, UF Lauren McIntyre, Ph.D., Department of Medical Genetics and Microbiology, UF Dan Hahn, Ph.D., Department of Entomology and Nematology, UF Maureen Keller-Wood, Ph.D., Department of Pharmacodynamics, UF Charles Wood, Ph.D., Department of Physiology, UF Hans Alborn, Ph.D. USDA Laboratory, Gainesville FL


William Brey, Ph.D., NHMFL Rafael Brüschweiler, Ohio State University Carrie Haskell-Luevano, Ph.D., Dept of Med Chem, University of Minnesota Frank Schroeder, Ph.D., Cornell University Paul Sternberg, Ph.D., HHMI and Biology, Caltech Peter Teal, Ph.D., USDA Labs, Gainesville FL Jorge Vivanco, Ph.D., Center for Rhizosphere Biology, Colorado State University Rich Withers, Ph.D., Agilent NMR Rob Nast, Ph.D., Agilent NMR

Outreach Personal Blog (http://edisonleatherworks.com/home/blog/): This site documents some of my outside

interests, career path, and musings on art, science, and education. Some of the primary target audiences for the blog are students and young adults who are facing career choices.

2005-Present: Participant in the National High Magnetic Field Laboratory College Outreach –

Workforce Initiative (CO-WIN) Program. This NSF program involves traveling annually to colleges and universities with significant numbers of underrepresented minority students. I present a seminar on opportunities at the NHMFL and meet with students and professors. The goal is to get talented students into labs for summer research projects in the NHMFL and to show them different options for graduate research.

Spring 2009-2012: Founder and leader of the Pine Ridge Science Club. The Pine Ridge

community is severely economically disadvantaged. I organized and led a weekly science club on Friday afternoons for about 9 children from 2nd to 5th grades. All of the students were poor and African American. We did activities similar to those described below for the Prairie View Science Club.

2003-2005: Founder and leader of the Prairie View Rattler Science Club. This was a weekly

science club for kids from 2nd to 5th grades in the after school program at Prairie View Elementary School. We did simple hands on activities in chemistry, biology, physics, environmental studies, and engineering that are designed to show the excitement of science. We specifically did not try to substitute for another science class. On alternate weeks, we provided math tutoring in either one-on-one sessions or in the form of math games played by the entire group. Over 90% of the students attending Prairie View are minority and qualify for Federal subsidized lunch programs. This ended when the after school program was eliminated.

Research Interests

1) Metabolomics. We are developing NMR and mass spectrometry-based approaches to metabolomics studies. This is highly interdisciplinary involving analytical chemistry, statistical analysis, computer technology, biochemistry, physiology, and other biophysical methods. The NIH Common Fund has funded the Southeast Center for Integrated Metabolomics (SECIM) (Edison, PI and Director) as one of the 6 regional metabolomics centers in the United States.

2) Natural Products Chemistry. The nematode Caenorhabditis elegans has been extensively

studied as a model organism for decades, but the chemistry used for communication between individuals and their environment is less extensively studied. We are using very high sensitivity


NMR and mass spectrometry, efficient chromatographic methods, and bioassays to identify biologically active secreted chemicals in the worm.

3) Methods development for high-sensitivity NMR. Through collaborations with groups in RF

engineering at the NHMFL, we have developed probes with small sample volumes and improved signal to noise for proteins and small molecule natural products. We are also working with groups to optimize calculations of NMR parameters and mixture analysis of small molecules.

External Grant Support ACTIVE

“Southeast Resource Center for Integrated Metabolomics (SECIM)” NIH/NIDDK, 1U24DK097209-

01A1, Edison, Corresponding Co-PI; Yost Co-PI, 09/01/13-08/31/18. To establish a regional center for metabolomics. $9.3M/5 yrs total .

NSF R00902 1/1/13-12/31/17 2.4 calendar FSU subcontract to UF (Long, PI), Edison 10% effort “National High Magnetic Field Laboratory” These funds support an external user program and develop new biological magnetic resonance technologies. Edison’s role is diversity and outreach and metabolomics interface.

PENDING: “Chemical linguistics: how nematodes translate their environment into molecules that mediate behavior”,

LOI to HFSP, Edison, PI (2015). Administrative Supplement to “Angiotensin and Neuroimmune Activation in Hypertension” (Raizada, PI),

NIH R01 supplement, submitted Feb 2015. Edison 0.6 FTE to assist with metabolomics. “Mitigation of induced proinflammation by SlpA:SIGNR3 interaction” (Mohamadzadeh, PI), NIH R01,

submitted Feb 2015. Edison 0.6 FTE to assist with metabolomics. “Effects of Maternal Cortisol on Fetal and Neonatal Growth and Metabolism” (Keller-Wood, PI), NIH R01,

07/01/15 – 06/30/20. Edison 0.6 calendar effort to assist with metabolomics. “Triclosan Exposure and Insulin Resistance in the Fetus and Newborn” (Wood, PI), NIH R01, 07/01/15—

06/30/19. Edison 0.6 calendar effort to assist with metabolomics. In Planning/Preparation: “Experimental and Computational Mapping of the C. elegans Metabolome” (Edison, PI), NIH planned

for fall, 2015; possibly other agencies. The primary goal is to create the most extensive and expandable metabolic map in any animal. We want to leverage worm genetics/genomics with pathway mapping and new global metabolomic methods.

COMPLETED:

NSF/IOS 0919998 07/01/10-06/30/13 0.6 calendar


Hahn, PI; Edison, Co-PI “Collaborative research: Integrating physiological and genetic mechanisms to understand the evolution of cold tolerance” To characterize small molecule metabolite markers of cold tolerance in insects

“Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy” (Vandenborne, PI; Edison and Walter, Co-PI), NIH/NIAMS RO1 AR056973 (supplement to parent grant), 05/01/12-04/30/14. Edison analyzed serum and urine from children with Duchene MD to develop biomarkers. NIH/NIBIB 1R01EB009772-01 08/01/09-06/30/2014 2.4 calendar Edison, PI; Brey, Co-PI $1,480,622/5 yrs “Improved NMR Technology for Natural Products and Metabolomics” The major goals were to build a new HTS NMR probe for the highest mass sensitivity for both 1H and 13C detection of natural products. NIH/NIGMS 1R01GM085285-01A1 05/01/09- 02/28/2014 2.4 calendar Edison, PI; Sternberg and Schroeder, Co-PIs $248,635: yr 1 direct “Comparative Behavioral Metabolomics in Nematodes” To isolate, identify, and characterize mating and dauer pheromones and receptors from several rhabditid species of nematode. NIH 1R01DK064250 09/15/2008-07/31/2013 1.2 calendar C. Haskell-Luevano, PI; Edison Co-PI $288,796/yr total “Endogenous G-Protein Coupled Receptor Antagonists” The major goals of this project were to design and characterize antagonists of melanocortin receptors. The Edison laboratory used NMR to model the conformation of select compounds. Edison provided assistance in NMR data collection and modeling. European Commission ERC-DIC 5 years total, Edison 2 year contract Michael Meijler, PI (Ben-Gurion University of the Negev, Beer-Sheva, Israel) $68,000 euro/2 yrs to Edison “An Integrated Chemical Platform to Elucidate Eukaryotic Sensing of Bacterial Crosstalk: QUORUMPROBES” This project utilized chemical probes to isolate quorum sensing (QS) receptors in a variety of organisms. NSF ARRA-R01218 1/1/08-12/31/12

FSU subcontract to UF (Edison, PI) $ 200,000 “National High Magnetic Field Laboratory”

These funds helped to purchase a 4.7T/33 cm animal imaging system for AMRIS. UF NHMFL Matching Funds 1/1/08-12/31/12 Institutional match (Edison, PI) $75,000/yr National High Magnetic Field Laboratory These funds supported a postdoc and supplies for the development of high sensitivity NMR to enhance the NHMFL external user program.

NIH/NIGMS 3R01GM085285-01A1S1 07/17/2009-06/30/2011 Edison, PI; Sternberg and Schroeder, Co-PIs $349,634 total for 2 years. “Administrative Supplement: Comparative Behavioral Metabolomics in Nematodes”


To expand Aim 4 of the parent grant to improve our mechanistic understanding of nematode chemical signaling. NIH/NCRR 1S10RR025671-01 01/16/2009 -01/15/2010 0.0 calendar Edison, PI; Walter, Blackband, Mareci, Co-PIs $500,000 total “Upgrade of an 11T/40cm MRI/S System” Shared instrumentation grant for 11T imaging console upgrade.

“Discovery of Caenorhabditis elegans Chemical Ecology”, Human Frontiers Science Program, Edison,

PI. Co-PIs: Paul Sternberg, Mario de Bono, Peter Teal, $350,000/yr, 5/1/05-4/30/08. The major goals of this project were to isolate, identify, and characterize C. elegans pheromones.

“High Field Magnetic Resonance Research and Technology”, NIH, P41 RR16105, PI: Steve

Blackband; Core PIs: Edison, Blackband, and Fitzsimmons, $5,145,741/5 yrs, 05/01/01 - 04/30/07 (1 year funded extension to 5 year grant). The major goals of this resource grant were to develop improved sensitivity for NMR and MRI measurements. This was the funding used to develop and build the high-sensitivity 1-mm HTS probe.

“Development of Molecular Imaging at UF”, UF Opportunity Fund, PI: Edison, $70,000, 4/01/05-3/30/06,

$70,000. The major goal of this project was to establish MRI molecular imaging at UF by bringing together particle scientists, cell biologists, physiologists, chemists, and imaging specialists.

“MARCKS-Actin Structure: Implications for neuroplasticity”, Veterans’ Administration, PI: M. Bubb,

Sub-contract: A. S. Edison, Subcontract $15,000/yr, 10/01/01-09/30/05. The major goals of this project were to characterize the biophysical properties of MARCKS.

“Novel Inhibitors of Fungal Aspartic Proteinases”, NIH 5R01AI049063, PI: B. Dunn, Co-PIs: A. S.

Edison, S. Hagen, $450,000/3 yrs, 2001-2004. The major goals were to structurally and dynamically characterize the folding and binding of IA-3, an endogenous inhibitor of yeast proteinase A.

“Structure-Function of FMRFamide like peptides”, National Science Foundation CAREER, PI: A. S.

Edison, $450,000 total costs, 06/1/99 - 05/31/04. The major goals of this project were to use NMR to study the structural basis of neuropeptide variability.

“Purchase of a Circular Dichroism Spectrometer”, NIH RR016765-01, PI: Edison, 03/01/02-02/28/03.

This was a shared instrumentation grant that resulted in an Aviv spectrometer with stopped flow. “Small bioeffector molecules of Streptococcus mutans”, NIH 5R01DE12327, PI: Hillman, Co-PI

Edison, 06/01/98 – 05/31/02. The major goals were to determine the structure of mutacin 1140, a potent and broad-spectrum antibiotic.

“NMR studies of the cardioactive neuropeptide FMRFamide bound to the FMRFamide-gated sodium

channel receptor”, PI: Edison, American Heart Association/Florida Affiliate, $225,000/3 yrs, 1997-2001. The major goals were to express a sodium channel and determine the bound structure of its ligand, FMRFamide.

Patents “NMR RF Probe Coil Exhibiting Double Resonance”, US Patent 8,779,768.


"Ascarosides as Nematode Sex Pheromones" US Patent 8318146 Peer reviewed publications (* indicates corresponding author) 1. Chaevien S. Clendinen‡, Gregory S. Stupp‡, Bing Wang, Timothy J. Garrett, Arthur S. Edison* “13C

Metabolomics: NMR and IROA for Unknown Identification”, Submitted, 2015. 2. Ardenkjaer-Larsen, J.H., Boebinger, G.S., Comment, A., Duckett, S., Edison, A.S., Engelke, F.,

Griesinger, C., Griffin, R.G., Hilty, C., Maeda, H., Parigi, G., Prisner, T., Ravera, E., Van Bentum, J., Vega, S., Webb, A., Luchinat, C., Schwalbe, H., and Frydman, L. (2015). Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy. Angew Chem Int Ed Engl. In Press

3. "Transferring Fungi to a Deuterium-Enriched Medium Results in Assorted, Conditional Changes in Secondary Metabolite Production" Wang, Bin; Park, Elizabeth; King, Jarrod; Mattes, Allison; Nimmo, Susan; Clendinen, Chaevien; Edison, Arthur; Anklin, Clemens; Cichewicz, Robert, In Press JNP (2015).

4. Chaevien S. Clendinen, Christian Pasquel, Ramadan Ajredini, Arthur S. Edison* “13C NMR Metabolomics: INADEQUATE Network Analysis”, Anal. Chem. 87(11), 5698-5706 (2015).

5. Jerris W. Hooker, Vijaykumar Ramaswamy, Rajendra K. Arora, Arthur S. Edison, Richard S. Withers, Robert E. Nast, and William W. Brey, “An Empirical Expression to Predict the Resonant Frequencies of Archimedean Spirals” In Press IEEE Transactions on Microwave Theory and Techniques, 2015.

6. Menger, R. F. ‡, Clendinen, C.‡, Searcy, L. A., Edison, A. S., & Yost, R. A.*, “MALDI Mass Spectrometric Imaging of the Nematode Caenorhabditis elegans” Current Metabolomics 3, 130-137 (2015).

7. “Facing and Overcoming Biomolecular NMR’s Sensitivity Challenges”, Jan Henrik Ardenkjaer-Larsen1, G. Boebinger2, Arnaud Comment3, Simon Duckett4, A. S. Edison5, Frank Engelke6, Christian Griesinger7, C. Hilty8, H. Maeda9, Giacomo Parigi10, Thomas Prisner11, Enrico Ravera10, Jan van Bentum12, Shimon Vega13, A. Webb14, Claudio Luchinat10*, Harald Schwalbe11* and Lucio Frydman7*, In Press, Angewandte Chemie (2015).

8. Frelin, O., Huang, L., Hasnain, G., Jeffryes, J. G., Ziemak, M. J., Rocca, J. R., Wang, B., Rice, J., Roje, S., Yurgel, S. N., Gregory, J. F., Edison, A. S., Henry, C. S., de Crecy-Lagard, V., and Hanson, A. D.* (2015) A directed-overflow and damage-control N-glycosidase in riboflavin biosynthesis., Biochem J 466, 137-145.

9. Clendinen, C. S., Lee-McMullen, B., Williams, C. M., Stupp, G. S., Vandenborne, K., Hahn, D. A., Walter, G. A., and Edison, A. S.* (2014) “¹³C NMR metabolomics: applications at natural abundance”, Analytical Chemistry 86, 9242-9250.

10. Williams, C. M., Watanabe, M., Guarracino, M. R., Ferraro, M. B., Edison, A. S., Morgan, T. J., Boroujerdi, A. F., and Hahn, D. A.* (2014) “Cold adaptation shapes the robustness of metabolic networks in Drosophila melanogaster”, Evolution 68, 3505-3523.

11. Singh, A., Dirain, M. L., Wilczynski, A., Chen, C., Gosnell, B. A., Levine, A. S., Edison, A. S., and Haskell-Luevano, C.” (2014) “Synthesis, Biophysical, and Pharmacological Evaluation of the Melanocortin Agonist AST3-88: Modifications of Peptide Backbone at Trp 7 Position Lead to a Potent, Selective, and Stable Ligand of the Melanocortin 4 Receptor (MC4R)”, ACS chemical neuroscience 5, 1020-1031.

12. Stupp, G.S., Clendinen, C., Ajredini, R., Szewc, M.A., Garrett, T., Menger, R.F., Yost, R.A., Beecher, C.* & Edison, A.S.* “Isotopic Ratio Outlier Analysis Global Metabolomics of Caenorhabditis elegans” Anal. Chem. 85, 11858-65 (2013).


13. Ramaswamy, V., Hooker, J.W., Withers, R.S., Nast, R.E., Brey, W.W*., Edison, A.S.* “Development of a 13C-Optimized 1.5-mm High Temperature Superconducting NMR Probe” J. Magn. Reson. 235C, 58–65. (2013).

14. Stupp, G. S., Reuss, von, S. H., Izrayelit, Y., Ajredini, R., Schroeder, F. C.*, and Edison, A. S.* (2013) “Chemical detoxification of small molecules by Caenorhabditis elegans” ACS chemical biology 8, 309–313. Featured in C&E News, Science and Technology Concentrates, Dec 3, 2012.

15. Choe, A.&, Chuman, T.&, von Reuss, S.H.&, Dossey, A.T.&, Yim, J., Ajredini, R., Kolawa, A.A., Kaplan, F., Alborn, H.T., Teal, P.E., Schroeder, F.C., Sternberg, P.W., & Edison, A.S.* “Gender-Specific Mating Pheromones in the Nematode Panagrellus redivivus”, PNAS 109, 20949-20954 (2012).

16. Singh, A., Dirain, M., Witek, R., Rocca, J. R., Edison, A. S., and Haskell-Luevano, C.* Structure-Activity Relationships of Peptides Incorporating a Bioactive Reverse-Turn Heterocycle at the Melanocortin Receptors: Identification of a 5800-fold Mouse Melanocortin-3 Receptor (mMC3R) Selective Antagonist/Partial Agonist versus the Mouse Melanocortin-4 Receptor (mMC4R). J. Med. Chem. 56, 2747–2763 (2013).

17. Fatma Kaplan; Hans T Alborn; Stephan H von Reuss; Ramadan Ajredini; Jared G Ali; Faruk Akyazi; Lukasz L Stelinski; Arthur S Edison; Frank C Schroeder; Peter E Teal*, "Interspecific nematode signals regulate dispersal behavior", PLoS One, 7(6), e38735, doi:10.1371/journal.pone.0038735 (2012).

18. Srinivasan, J., von Reuss, S.H., Bose, N., Mahanti, P., Ho, M.C., O’Doherty, O.G., Edison, A.S., Sternberg, P.W.* & Schroeder, F.C.*, “A modular library of small molecule signals regulates social behaviors in Caenorhabditis elegans”, PLoS Biol 10(1): e1001237. doi:10.1371/journal.pbio.1001237 (2012).

19. Singh, A., Wilczynski, A., Holder, J.R., Witek, R.M., Dirain, M.L., Xiang, Z., Edison, A.S., & Haskell-Luevano, C.* “Incorporation of a Bio-Active Reverse-Turn Heterocycle into a Peptide Template Using Solid-Phase Synthesis to Probe Melanocortin Receptor Selectivity and Ligand Conformations by 2D 1H NMR”, J. Med. Chem 54(5):1379-90 (2011). PMID: 21306168

20. Robinette, S.L., Ajredini, R., Rasheed, H., Zeinomar, A., Schroeder F.C., Dossey, A.T., & Edison, A.S.*, “Hierarchical Alignment and Full Resolution Pattern Recognition of 2D NMR Spectra: Application to Nematode Chemical Ecology.”, Analytical Chemistry 83 (5), 1649–1657 (2011). PMID: 21314130

21. Kaplan, F., Srinivasan, J., Mahanti, P., Ajredini, R., Durak, O., Nimalendran, R., Sternberg, P.W., Teal, P.E.A, Schroeder, F.C., Edison, A.S., and Alborn, H.T.*, “Ascaroside expression in Caenorhabditis elegans is strongly dependent on diet and developmental stage”, PLoS One 6(3):e17804, (2011). PMID: 21423575

22. Waller, J.C., Alvarez, S., Naponelli, V., Lara-Nuñez, A., Blaby, I.K., Da Silva, V., Ziemak, M.J., Vickers, T.J., Beverley, S.M., Edison, A.S., Rocca, J.R., Gregory III, J.F., de Crécy-Lagard, V., & Hanson, A.D.* “A Newly Discovered Role for Tetrahydrofolates in the Metabolismof Iron-Sulfur Clusters in All Domains of Life”, PNAS 107, 10412-72010 (2010). PMID: 20489182

23. Kaplan, F., Badri, D. V., Zachariah, C., Ajredini, R., Sandoval, F. J., Roje, S., Levine, L. H., Zhang, F., Robinette, S. L., Alborn, H. T., Zhao, W., Stadler, M., Nimalendran, R., Dossey, A. T., Brüschweiler, R. A., Vivanco, J. M., Edison, A. S.* “Bacterial Attraction and Quorum Sensing Inhibition in Caenorhabditis elegans Exudates”, Journal of Chemical Ecology 35(8):878-92 (2009). PMID: 19649780

24. Dossey, A. T.*, Gottardo, M., Whitaker, J., Roush, W. R., & Edison, A. S. “AlkylDimethylpyrazines in the Defensive Spray of Phyllium westwoodii: A First for Order Phasmatodea”, Journal of Chemical Ecology 35(8):861-70 (2009). PMID: 19685263. This is a cover article.


25. Wang, B., Dossey, A. T., Walse, S. S., Edison, A. S., and Merz, K.M. Jr.* “Relative Configuration of Natural Products by NMR Chemical Shifts”, Journal of Natural Products 72, 709-13 (2009). PMID: 19265431

26. Dalisay, D. S., Rogers, E. W., Edison, A. S., Molinski, T. F.* Structure Elucidation at the Nanomole-Scale. Trisoxazole macrolides and Thiazole-containing cyclic peptides from the Nudibranch Hexabranchus sanguineus, Journal of Natural Products 72, 732-8 (2009). PMID: 19254038

27. Narayanan, R., Ganesh, O., Edison, A. S., Hagen, S.J.* “Kinetics of folding and binding of an intrinsically disordered protein: the inhibitor of yeast aspartic proteinase YPrA”, J. Am. Chem. Soc. 130(34), 11477-85 (2008). PMID: 18681437

28. Srinivasan, J., Kaplan, F., Ajredini, R., Zachariah, C., Alborn, H., Teal, P., Edison, A. S.*, Paul W. Sternberg, P. W.*, & Schroeder, F. C.* “A synergistic blend of small molecules differentially regulates both mating behavior and population density in Caenorhabditis elegans.”, Nature 454, 1115-1118 (2008). PMID: 18650807 Featured in Nature Chemical Biology and SpectroscopyNOW.com

29. Dossey, A. T., Walse, S. S., & Edison, A. S.* “Developmental and Geographical Variation in the Chemical Defense of the Walkingstick Insect Anisomorpha buprestoides” Journal of Chemical Ecology, 34(5), 584-590 (2008). PMID: 18401661

30. Woodling, K. A., Eyler*, J. R., Tsybin, Y. O., Nilsson, C. L., Marshall, A. G., Edison, A. S., Al-Naggar, I. M., & Bubb, M. R. “Identification of single and double sites of phosphorylation by ECD FT-ICR/MS in peptides related to the phosphorylation site domain of the myristoylated alanine-rich C kinase protein.” J Am Soc Mass Spectrom. 18, 2137-45 (2007). PMID: 17962038

31. Zhang, F.; Dossey, A. T.; Zachariah, C.; Edison, A. S., & Brüschweiler, R.* “Strategy for Automated Analysis of Dynamic Metabolic Mixtures by NMR - Application to an Insect Venom”, Anal Chem. 79, 7748-52. (2007). PMID: 17822309

32. Dossey, A. T.; Walse, S. S.; Conle, O. V.; Edison, A. S. * “Parectadial: A Novel Monoterpenoid from the Defensive Spray of Parectatosoma mocquerysi”, J Nat Prod. 70, 1335-8 (2007). PMID: 17661519 JNP 2007 Hot Article, C&E News, Beal Award

33. Dossey, A. T., Walse, S. S., Rocca, J. R., & Edison, A. S.* “Single Insect NMR: A New Tool to Probe Chemical Biodiversity” ACS Chemical Biology, 1 (8), 511–514 (2006). PMID: 17168538 This was a cover article and was also featured in C&E News in “News of the Week”, Sept. 25, 2006, page 15

34. Ganesh, O. K., Green, T. B., Edison, A. S., & Hagen, S. J.* “Characterizing the Residue Level Folding of the Intrinsically Unstructured IA3” Biochemistry 45, 13585-96 (2006). PMID: 17087512

35. Dossey, A. T., Reale, V., Chatwin, H., Zachariah, C., de Bono, M. Evans, P. D., & Edison, A.S.* “Structure and Function Studies of C. elegans FLP-18 Neuropeptides: Implications in NPR-1 Activation”, Biochemistry 45, 7586-97 (2006). PMID: 16768454

36. Brey, W., Edison, A.S.*, Nast, R.E., Rocca, J., Saha, S., & Withers, R. “Design, Construction, and Validation of a 1-mm Triple-Resonance High-Temperature-Superconducting Probe for NMR” Journal of Magnetic Resonance 179, 290-3 (2006). PMID: 16423543 This was a cover article.

37. Li, Y, Webb, A., Saha, S., Brey, W., Zachariah, C., Edison, A. S.* “Investigation of conductor geometry effects on the signal-to-noise of small solenoid coils for high-field protein NMR experiments” Magnetic Resonance in Chemistry 44, 255-62 (2006).

38. Fu, R., W. W. Brey, K. Shetty, P. Gor’kov, S. Saha, J. R. Long, S. C. Grant, E. Y. Chekmenev, J. Hu, Z. Gan, M. Sharma, F. Zhang, T. M. Logan, R. Brüschweller, A. Edison, A. Blue, I. R. Dixon, W. D. Markiewicz, and T. A. Cross “Ultra-Wide Bore 900 MHz High-Resolution NMR at the National High Magnetic Field Laboratory”, J. Magn Reson, 177, 1-8 (2005). This was a cover article.


39. Wilczynski, A., Wilson, K. R., Scott, J. W., Edison, A. S., and Haskell-Luevano, C.* "Structure-Activity Relationships of the Unique and Potent Agouti Related Peptide (AGRP)-Melanocortin Chimeric Tyr-c[Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Peptide Template", J Med Chem. 2005 48(8), 3060-75.

40. Tapp, H., Al-Naggar, I. M., Yarmola, E. G., Harrison, A., Shaw, G., Edison, A. S., and Bubb, M. R.*, “MARCKS is a natively unfolded protein with an inaccessible actin-binding site: evidence for long-range intramolecular interactions”, J Biol Chem. 2005 280(11), 9946-56.

41. Wilczynski, A., Wang, X. S., Bauzo, R. M., Xiang, Z., Shaw, A. M., Millard, W. J., Richards, N. G., Edison, A. S., and Haskell-Luevano, C.* " Structural Characterization and Pharmacology of A Potent Bicyclic Agouti-Related Protein (AGRP) Melanocortin Receptor Antagonist" J. Med. Chem. 47, 5662-73 (2004).

42. Wang, H., Ciobanu, L., Edison, A. S., and Webb, A. G.* “An Eight-coil High Frequency Probehead Design for High-Throughput Nuclear Magnetic Resonance Spectroscopy” J Magn Reson 170, 206-12. (2004).

43. Green, T. Ganesh, O., Perry, K., Smith, L., Phylip, L. H., Logan, T. M., Hagen, S. J., Dunn, B. M., Edison, A. S.*, “IA3, an Aspartic Proteinase Inhibitor from Saccharomyces cerevisiae, is Intrinsically Unstructured in Solution” Biochemistry 43, 4071-4081 (2004). PMID: 15065849

44. Makokha, M., Huang, Y. J., Montelione, G., Edison, A. S., & Barbar, E.* “The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila” Protein Science 13: 727-734 (2004). PMID: 14767079

45. Li, Y., Logan, T. M., Edison, A. S. and Webb, A.* “Design and Optimization of High Sensitivity Small Volume Probes for Improved Limits of Detection in Protein NMR experiments” Journal of Magnetic Resonance 164, 128-135 (2003).

46. Smith, L., Zachariah, C., Thirumoorthy, R., Rocca, J., Novák, J., Hillman, J. D., and Edison, A. S.* ”Structure and Dynamics of the Lantibiotic Mutacin 1140” Biochemistry 42(35), 10372-10384 (2003). PMID: 12950164

47. Thirumoorthy, R., Holder, J. R., Bauzo, R. M., Richards, N. G. J., Edison, A. S.*, and Haskell-Luevano, C. “Novel Agouti-related Protein (AGRP)-Based Melanocortin-1 Receptor Antagonist” J. Med. Chem. 44, 4114-4124 (2001).

48. Zachariah, C., Cameron, A., Lindberg, I., Kao, K. J., Beinfeld, M. C., and Edison, A. S.* “Structural Studies of a Neuropeptide Precursor Protein with an RGD Proteolytic Site” Biochemistry 40, 8790-8799 (2001). PMID: 11467939

49. Yarmola, E. G., Edison, A. S., Lenox, R. H., and Bubb, M. R.* “Actin filament cross-linking by MARCKS: Characterization of two actin-binding sites within the phosphorylation-site domain” J. Biol. Chem. 276, 22351-8. (2001).

50. Edison, A. S.* “Linus Pauling and the Planar Peptide Bond” Nature Structural Biology 8, 201-202 (2001).

51. Smith, L., Novak, J., Rocca, J., McClung, S., Hillman, J.D., and Edison, A.S.* “Covalent structure of mutacin 1140 and a novel method for the rapid identification of lantibiotics”, European Journal of Biochemistry, 267, 6810-6816 (2000).

52. Carlacci, L.* and Edison, A. S. “Computational Analysis of Two Similar Neuropeptides Yields Distinct Conformational Ensembles”, Proteins: Structure, Function, and Genetics 40, 367-377 (2000).


53. Bubb, M. R., Lenox, R. H., and Edison, A. S.* “Phosphorylation-dependent Conformational Changes Induce a Switch in the Actin-binding Function of MARCKS”, J. Biol. Chem. 274: 36472-36478 (1999). PMID: 10593944

54. Edison, A. S.*, Espinoza, E., and Zachariah, C. “Conformational Ensembles: The Role of Neuropeptide Structures in Receptor Binding”, J Neurosci. 19:6318-6326, 1999.

55. Sorgen, P. L., Bubb, M. R., McCormick, K. A., Edison, A. S., and Cain, B. D.* “Formation of the β Subunit Dimer is Necessary for Interaction with F1-ATPase Biochemistry 37, 923-932 (1998). PMID: 9454582

56. Edison, A. S., Messinger, L. A., and Stretton, A. O. W.*, "afp-1: A Gene Encoding Multiple Transcripts of a New Class of FMRFamide-like Neuropeptides in the Nematode Ascaris suum", Peptides 18 929-935 (1997).

57. Edison, A. S., Markley, J. L., and Weinhold, F.*, “Theoretical studies of protium/deuterium fractionation factors and cooperative hydrogen bonding in peptides”, J. Am. Chem. Soc., 117, 9619 (1995).

58. Edison, A. S., Markley, J. L., and Weinhold, F.*, “Ab initio calculations of protium/deuterium fractionation factors in O2H5+ clusters”, J. Phys. Chem., 99, 8013 (1995).

59. Panasik, N. Jr., Eberhardt, E. S., Edison, A. S., Powell, D. R., and Raines, R. T.*, “Inductive effects on the structure of proline residues”, Int. J. of Peptide and Protein Res., 44, 262 (1994).

60. Edison, A. S., Weinhold, F., Westler, W. M., and Markley, J. L.*, “Estimations of φ and ψ torsion angles in proteins from one-, two-, and three-bond nuclear spin-spin couplings: application to staphylococcal nuclease”, J. Biomol. NMR, 4, 543 (1994).

61. Edison, A. S., Markley, J. L., and Weinhold, F.*, “Calculations of one-, two-, and three-bond nuclear spin-spin couplings in a model peptide and correlations with experimental data”, J. Biomol. NMR, 4, 519 (1994).

62. Buckley, P., Edison, A. S., Kemple, M. D., and Prendergast, F. G.*, “13Cα-NMR assignments of melittin in methanol and chemical shift correlations with secondary structure”, J. Biomol. NMR, 3, 639 (1993).

63. Byeon, I. L., Yan, H., Edison, A. S., Mooberry, E. S., Abildgaard, F., Markley, J. L., and Tsai, M-D.*, “Mechanism of Adenylate Kinase. 1H, 13C, and 15N NMR Assignments, Secondary Structures, and Substrate Binding Sites”, Biochemistry, 32, 12508 (1993).

64. Edison, A. S., Markley, J. L., and Weinhold, F.*, “Calculations of Nuclear Spin-Spin Coupling Constants with Ab Initio Molecular Orbital Wavefunctions”, J. Phys. Chem., 97, 11657 (1993).

65. Dzakula, Z., Edison, A. S., Westler, W. M., and Markley, J. L.*, “Analysis of χ1 Rotamer Populations from NMR Data by the CUPID Method”, J. Am. Chem. Soc. 114 6200 (1992).

66. Dzakula, Z., Westler, W. M., Edison, A. S., and Markley, J. L.*, “The CUPID Method for Calculating the Continuous Probability Distribution of Rotamers from NMR Data”, J. Am. Chem. Soc. 114 6195 (1992).

67. Epstein, W. W.*, Klobus, M. A., and Edison, A. S., “Irregular Monoterpene Constituents of Artemisia tridentata cana. The Isolation, Characterization, and Synthesis of Two New Chrysanthemyl Derivatives”, J. Org. Chem. 56 4451 (1991).


68. Edison, A. S., Westler, W. M., and Markley, J. L.*, “Elucidation of Amino Acid Spin Systems in Proteins and Determination of Heteronuclear Coupling Constants by Carbon-Proton-Proton Three-Dimensional NMR”, J. Magn. Reson. 92 434 (1991).

69. Edison, A. S.*, “Propagation of an error: β-sheet structures”, TIBS 15 216 (1990).

Book Chapters, Invited Reviews, and not reviewed

70. “Metabolomics and Natural Products Strategies to Study Chemical Ecology in Nematodes” Arthur S. Edison*, Chaevien Clendinen, Ramadan Ajredini, Chris Beecher, Francesca Ponce, and Gregory Stupp. In Press, Invited contribution to the Journal of Integrative and Comparative Biology (2015)

71. “An Overview of Methods for Improved Compound Identification in Metabolomics and Natural Products Using 13C.” Arthur S. Edison*, Chaevien S. Clendinen, Gregory S. Stupp+, Ramadan Ajredini, and Chris Beecher. Submitted, Invited contribution to Frontiers in Plant Science (2015).

72. Bearden, D. W.; Beger, R. D.; Broadhurst, D.; Dunn, W.; Edison, A.; Guillou, C.; Trengove, R.; Viant, M.; Wilson, I. Metabolomics 2014, 10, 539-540.

73. Ramaswamy, J.W. Hooker, R.S. Withers, R.E. Nast, A.S. Edison*, W.W. Brey, Microsample Cryogenic Probes: Technology and Applications, eMagRes. 2 (2013) 215–228.

74. Wolfender, J.-L.*, Bohni, N., Ndjoko-Ioset, K., and Edison, A.S. “Advanced Spectroscopic Detectors for Identification and Quantification: Nuclear Magnetic Resonance”, chapter in LIQUID CHROMATOGRAPHY: APPLICATIONS, Elsevier, edited by Salvatore Fanali, Paul R. Haddad, Colin F. Poole, and Peter J. Schoenmakers In Press (2013)

75. Robinette, S.L., Brüschweiler, R., Schroeder, F.C., & Edison, A.S. “NMR in Metabolomics and Natural Products Research: Two Sides of the Same Coin”, Accounts of Chemical Research 45, 288-97 (2012).

76. Edison, A. S. “C. elegans Pheromones Regulate Multiple Complex Behaviors”, Current Opinion in Neurobiology 19(4):378-88. (2009). PMID: 19665885

77. Edison, A. S., Cosio, E., Halloy, S., & Vivanco, J. “So, you want to do research in the rainforest?”, Chapter in Chemical Biology of the Tropics. Eds: Vivanco JM, Weir TL. Springer (2011).

78. Edison, A. S. & Schroeder, F. C. “Modern Methods in Natural Product Chemistry - Characterization Methodologies: (I) NMR Spectroscopy of Small Molecules and Analysis of Complex Mixtures” In Comprehensive Natural Products II Chemistry and Biology; Mander, L., Lui, H.-W, Eds.; Elsevier: Oxford, 2010; Vol. No. 9, pp 169-196.

79. Edison, A. S. & Long, J. R. “The Magic of Solenoids” Nature News & Views, 447, 646-7 (2007). PMID: 17554293

80. Long, J. R., Samuel-Landtiser, M., Zachariah, C. Williams, C., & Edison, A. S. “Incorporation of Isotopically Enriched Amino Acids” Current Protocols in Protein Science, 2007 Feb; Chapter 26:Unit 26.3. PMID: 18429325

81. Schneider-Muntau, H. J., Brandt, B. J., Brunel, L. C., Cross, T. A., Edison, A. S., Marshall, A. G., and Reyes, A. P. “The National High Magnetic Field Laboratory” Physica B, 346-347 (2004), 643-648.

82. Agbandje-McKenna, M., Edison, A. S., and McKenna, R. “Biophysical Methods in Structural Biology” In Essential Cell Biology: Volume 1: Cell Structure” pp. 269-291, Eds. J. Davey and M. Lord, Oxford University Press (2003).


83. Edison, A. S. Review of “Theoretical Biochemistry: Processes and Properties of Biological Systems. Theoretical and Computational Chemistry 9.” Edited by Leif A. Eriksson (Uppsala University). Elsevier: Amsterdam. 2001. xiv + 704 pp. $372. ISBN: 0-444-50292-0. J. Am. Chem. Soc. 124(26); 7875-7876 (2002).

84. Espinoza, E., Carrigan, M., Thomas, S. G., Shaw, G., and Edison, A. S.* “A statistical view of FMRFamide neuropeptide diversity”, Molecular Neurobiology 21, 35-56 (2001).

85. Edison, A. S.* “Review of Amino Acids and Peptides by G. C. Barrett & D. T. Elmore, Cambridge University Press”, The Quarterly Review of Biology 75 (1), page 50 March (2000).

86. Edison, A. S., Abildgaard, F., Westler, W. M., Mooberry, E. S., and Markley, J. L.*, “Practical introduction to the theory and implementation of multinuclear, multidimensional NMR experiments”, Methods Enzymol., N. J. Oppenheimer and T. L. James, eds., Vol. 239, pp. 1-79 (1994).

Public Speaking

Invited Conferences and Guest Teaching

July 5, 2015 Plenary lecture, EUROMAR, Prague, Czech Republic. June 16, 2015 After dinner speaker for the UAB Metabolomics Workshop. Jan 7, 2015 “Metabolomics as a tool to study chemical communication” Society for Integrative

and Comparative Biology, West Palm Beach, FL (Jan 3-7, 2015)

Oct 25, 2014 “What’s New in Metabolomics?” Center for Inflamation and Mucosal Immunology Retreat, University of Florida.

Sept 11, 2014 Guest NMR lecture in metabolomics workshop at UC-Davis.

Aug 11-15, 2014 Guest lecturer at Instituto de Química - UNESP – Car, Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais – NuBBE: 4 classes in NMR and metabolomics.

July 26, 2014 “13C-based Metabolomics: Integrating LC-MS IROA with NMR”, International Metabolomics Society meeting, Tsuruoka, Japan.

Nov 3, 2013 “Lunch with a Scientist” for the Science Writers 2013 conference, Gainesville FL

Oct. 10, 2013 Invited speaker Florida Genetics 2013 “New Approaches in Metabolomics”

June 1-7, 2013 Invited discussion leaders at the Computational Aspects of Metabolomic NMR Gordon Research Seminar and Computational Aspects of Biomolecular NMR Gordon Research Conference. Unable to attend because of accident.

May 19-24, 2013 Invited speaker at the 18th International Society of Magnetic Resonance (ISMAR), Rio de Janeiro, Brazil. Unable to attend because of accident.

April 14-19, 2013 Invited speaker at the 54th ENC, Asilomar, CA.

Mar 18-19, 2013 Visiting guest lecturer for introductory classes in NMR for general and organic chemistry undergraduate students. Claflin University, Orangeburg, S.C.

March 15, 2013 Invited speaker at the 10th SERCAT Structure Biology Symposium, Florida State University.


Feb 26-28, 2013 Invited lecturer in “BioNMR Foresight Workshop”, Weizmann Institute, Rehovot Israel.

Jan 24-26, 2013 Plenary Speaker: 2nd International Conference on Computational Biomedicine, University of Florida.

Nov 1-28, 2012 Fulbright specialist, University of Buenos Aires.

June 27-28, 2011, 35th Steenbock Symposium: Advances in Biomolecular NMR.

May, 2011 Visiting guest lecturer for a 3 day class (9 hours total) in NMR, metabolomics, and statistical analysis. UNESP, Araraquara, São Paolo, Brazil.

April, 2011 The XL Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq): April 30th to May 3rd, 2011 in Foz do Iguaçu, Paraná, Brazil.

March 9-11 Visiting guest lecturer for introductory classes in NMR for general and organic chemistry undergraduate students. Claflin University, Orangeburg, S.C.

Oct, 2010 Plenary Speaker Latin American Association of Chemical Ecology (ALAEQ), Colonia del Sacramento, Uruguay, October 17-20, 2010.

July, 2010 Invited Speaker EUROMAR 2010 and 17th International Society of Magnetic Resonance Conference, Florence Italy, July 5-9, 2010

Feb, 2010 Lecturer in 2 day metabolomics class in UNESP, Araraquara, São Paolo, Brazil. Feb, 2010 Plenary lecture at the 1st Workshop on Metabolomics in the Context of Systems

Biology: A Rational Approach to Search for Lead Molecules from Nature, São Paulo city, State of São Paulo, February, 25-26, 2010.

Jan, 2010 Invited Speaker at LabAutomation 2010: “High Sensitivity NMR Probes for Natural

Products and Metabolomics”, Palm Springs, CA January 25-27, 2010. Nov, 2009 Plenary lecture at 2nd Brazilian Conference on Natural Products (2nd BCNP), São

Pedro - SP – Brazil, November 9-12, 2009 Aug, 2009 Lecturer in NMR workshop for Fifth Annual International Conference of the

Metabolomics Society, Edmonton, Alberta, Canada, August 28-Sept 2. Jan, 2009 EU-NMR Annual Meeting, Autrans, France: “Would the EU-NMR Model Work in

the USA?” Oct, 2008 Southeast Magnetic Resonance Conference, Tallahassee, FL: “WORM SEX AND

DEVELOPMENT: HIGH SENSITIVITY NMR IN BIOLOGY July, 2008 Human Frontier Science Program Annual Meeting, Berlin, Germany: “Identification

of Caenorhabditis elegans Mating Pheromone: Relationship Between Mating and Dauer”

June, 2008 PASI (Pan-American Advanced Studies Institute): Interdisciplinary Studies in the

Chemical Biology of the Tropics (Tambopata National Reserve, Peru) May, 2008 Gordon Conference: ‘Computational Aspects – Biomolecular NMR’, May 18 -23,

2008, Il Ciocco, Italy. “The Life of a Worm: Sex, Eating, and Starvation: The Role


of Small Molecules in the Ecology of C. elegans”

Sept, 2007 Small Molecule NMR Conference, Chamonix France “Ultra high sensitivity NMR for insects and worms”

July, 2007 American Society of Pharmacognosy, Portland Maine “Single Insect NMR” April, 2006 Experimental NMR Conference, Asilomar CA “Ultra High Sensitivity NMR: 1-mm

HTS Triple Resonance Probe” March, 2005 Sanibel Symposium “Not all proteins are well-behaved spheres: Experimental and

theoretical challenges in unstructural biology” Nov, 2004 Southeastern Regional NMR meeting of the ACS “Microcoils for protein NMR” Nov, 2002 Southeast American Society of Micobiologists (SEASM) “Structure and

function of the lantibiotic mutacin 1140” Nov, 2000 Neuroscience Meeting, New Orleans “Phosphorylation-dependent

conformational changes determine the actin-binding function of MARCKS.” May, 1999 Florida ACS Meeting, Orlando FL “NMR Measurements of Reverse Turns in

Neuropeptides and Correlations with Receptor Binding Affinities” May, 1998 Florida ACS meeting “Structure/Function Studies of Neuropeptides” Invited Seminars

May 15, 2015 “Developments in Metabolomics” Research seminar Whitney Laboratory May 14, 2015 “Sex in the Soil”, Public lecture at the Whitney Laboratory, University of Florida Jan 16, 2015 University of Georgia, “"The lnterplay Between Technology, Natural Products,

and Metabolomics” Oct 16, 2014 “Development of 13C Metabolomics” University of Florida, Department of

Physics Symposium. Sept 24, 2014 University of Georgia, “Development of 13C Metabolomics” Sept 12, 2014 SRI International, Menlow Park, CA, “Development of 13C Metabolomics” July 2, 2014 Institute of Plant and Environmental Protection (IPEP), Beijing Academy of

Agricultural and Forestry Science (BAAFS), “Development of 13C Metabolomics”

July 3, 2014 Modern Research Center for Traditional Chinese Medicine of Shanxi

University, Taiyuan, Wucheng 92, 03006, China, “Development of 13C Metabolomics”

May 1, 2014 University of Michigan, “Development of 13C Metabolomics”


April 9-11, 2014 Claflin University, Introduction to Metabolomics, biochemistry lecture, and lab. Feb 21, 2014 University of North Florida, Joint Chemistry & Biology seminar. Feb 13, 2014 UF Nephrology Department. Jan 27, 2014 “What’s New in Metabolomics?” UF Center for Neurogenetics. Jan 13, 2014 “What is the Role of NMR in Metabolomics?”, Agilent Technologies, Santa

Clara CA Dec 12, 2013 "Improving NMR Sensitivity (why a 1.7-mm cryoprobe is a good choice!)",

Noble Foundation for the commissioning of a new NMR system. Dec 12, 2013 "Nematode Chemical Communication", Noble Foundation, Ardmore OK Sept 6, 2013 “Metabolomics from Worms to People”, Dept of Animal Science, UF.

Nov 27, 2012 “Nematode Chemical Ecology” University of Buenos Aires, Argentina Nov 23, 2012 “Nematode Metabolomics” University of Montevideo, Uruguay Nov 21, 2012 “The National High Magnetic Field Laboratory” Leloir Institute, Buenos Aires,

Argentina Nov 21, 2012 “Nematode Chemical Ecology” Leloir Institute, Buenos Aires, Argentina Nov 19, 2012 “The National High Magnetic Field Laboratory” University of Buenos Aires,

Argentina Nov 2, 2012 “Introduction to Metabolomics” University of Buenos Aires, Argentina March 27, 2012 Science Café, Thomas University, Thomasville, GA: “Sex in the Soil”. May 9, 2011 Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru: “Chemical

Ecology of Nematodes” March 22, 2011 University of Mississippi, National Center for Natural Products Research March 11, 2011 “Nematode Chemical Ecology”, Claflin University, Orangeburg, S.C. March 1, 2011 Science Café, NHMFL. “Sex in the Soil” (public talk on nematode chemical

biology) Feb 25, 2011 University of Florida, Animal Sciences Feb 4, 2011 New College-Florida. “The Chemistry of Worm Sex” Jan 12, 2011 New York University, Department of Biology. “Chemical Communication in

Nematodes.”


May 20, 2010 University of Toronto, Department of Chemistry. March 15, 2010 University of Florida, Department of Entomology and Nematology Jan 14, 2010 University of Florida, Department of Chemistry. “NMR technology for natural

products: Applications to nematode mating pheromones” Sept 24, 2009 University of Oklahoma, Dept of Chemistry & Biochemistry: Karcher Lecture

Award: “Technology and Applications in Natural Products” Sept, 2009 Claflin College, Dept of Biology & Chemistry, Orangeburg, SC Feb 2, 2009 Imperial College, London: “High-Sensitivity NMR and Natural Products” Jan 29, 2009 Neurospin, Saclay, France: “The NHMFL and High-Sensitivity NMR” Jan 22, 2009 University of Florida, Dept of Physics: “Development of High-Sensitivity NMR

for the Discovery of Molecules Used in Biological Communication” Oct 15, 2008 City College, CUNY, NYC, New York: “The Life of a Worm: Sex, Eating, and

Starvation” Oct 14, 2008 City College, CUNY, NYC, New York: “Opportunities for research at the

National High Magnetic Field Laboratory” Oct 8, 2008 University of Florida, Dept of Neuroscience: “The Life of a Worm: Sex, Eating,

and Starvation” Aug 8, 2008 Varian, Palo Alto, CA: “High-Sensitivity NMR for Natural Products” Feb 8, 2007 University of Texas, El Paso: “Opportunities for research at the National High

Magnetic Field Laboratory” Dec 4, 2007 Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru: “Ultra High-

Sensitivity NMR and Applications in Natural Products” Oct 17, 2007 Pontificia Universidad Católica Del Perú (PUCP), Lima, Peru: “Opportunities

for research at the National High Magnetic Field Laboratory” Oct 4, 2007 Eisai Research Institute, Andover, Massachusetts “Ultra High-Sensitivity NMR

and Applications in Natural Products” April 3, 2007 Colorado State University: “Ultra High-Sensitivity NMR and Applications in

Natural Products” Feb 9, 2007 University of Texas, El Paso: “Ultra High-Sensitivity NMR and Applications in

Natural Products” and “Opportunities for research at the National High Magnetic Field Laboratory”


Jan 24, 2007 Southern University, Baton Rouge Louisiana: “Opportunities for research at the National High Magnetic Field Laboratory”

Dec 12, 2006 University of California at San Diego and Scripps Institute for Oceanography:

“Ultra High-Sensitivity NMR and Applications in Natural Products” Nov 17, 2006 University of Central Florida, Orlando Florida: “Ultra High-Sensitivity NMR and

Applications in Natural Products” May 12, 2005 Scripps Florida, Jupiter Florida: “NMR Technology for Small Volume Samples and

Two Short Stories in Unstructural Biology” April 21, 2005 Protein Folding Group, Louisiana State University, University of New Orleans,

Loyola University, and Xavier University: “Unstructural Biology”. April 21, 2005 Xavier University, New Orleans: “Opportunities for research at the National High

Magnetic Field Laboratory” April 20, 2005 Dillard University, New Orleans: “Opportunities for research at the National High

Magnetic Field Laboratory” May 13, 2004 Oregon State University, Department of Chemistry and Biochemistry: “Unstructural

Biology: IA-3 simultaneously folds while binding to yeast proteinase A” Sept. 19, 2003 Florida Atlantic University, Department of Chemistry: “Structural and

thermodynamic investigations of IA3, an unfolded protease inhibitor that folds upon binding to yeast proteinase A”

Nov. 15, 2002 Ohio University, Department of Chemistry & Biochemistry: “Structural studies of

neuropeptides” Sept. 18, 2000 University of Utah Chemistry Department: “Structural Studies of partially folded

proteins” Feb. 5, 1999 University of Vermont Department of Biochemistry: “Neuropeptide signaling as

seen through the eyes of NMR” Oct. 13, 1998 Florida State University Structural Biology: “Signaling Diversity in the Nervous

System” Oct. 8, 1998 Florida State University Physics: “NMR spectroscopy as a probe of

neuropeptide conformations” Apr. 27, 1998 Louisiana State University Department of Chemistry, New Orleans: “Structure/Function Studies of Neuropeptides” Apr. 26, 1998 Loyola University Department of Chemistry, New Orleans: “Conformational

Studies of neuropeptides by NMR and Monte Carlo simulated annealing” Dec. 5, 1997 Ohio State University Department of Chemistry: “Structure/Function Studies of

Neuropeptides”


Dec. 4, 1997 Ohio Wesleyan University Department of Chemistry: “Structure/Function

Studies of Neuropeptides” Nov. 24, 1997 University of Utah Department of Chemistry: “Structure/Function Studies of

Neuropeptides using NMR and Molecular Biology”

CURRICULUM VITAE Arthur S. Edison,...

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