CTSI Research Associates Program: Building Future Leaders ... · Poster Print Size: This poster...
1
CTSI Research Associates Program: Building Future Leaders in Clinical Research KELSEY JIANG, STEVYDENNIS ONGGO, MICHELLE GUAN, JAR-YEE LIU, Noah Federman, Laurie Shaker-Irwin University of California, Los Angeles, Los Angeles, CA The UCLA CTSI Research Associates Program (CTSI-RAP) aims to provide UCLA undergraduate students with the opportunity to gain exposure to hospital-based medicine as well as clinical research. The program is designed to strengthen interest in biomedical research ini@a@ves by allowing first-hand interac@on between UCLA faculty physicians and inves@gators with undergraduate students. Research associates play a key role in the implementa@on of research protocols when they are given the opportunity to assist primary inves@gators with various aspects of their project including, but not limited to, consen@ng pa@ents, collec@ng secured data, and co-authoring abstracts, posters, and papers. In addi@on, students are given the opportunity to make rounds with the medical team, observe common procedures, and experience didac@c teaching sessions during the course of their involvement in the program. Outside of direct research experience, the CTSI-RAP students are exposed to situa@ons meant to educate and prepare them for a career in healthcare. As a result, research associates become comfortable with the inner- workings of a hospital and gain skills in professionalism, pa@ent communica@on, and research methodology. The unique blend of first-hand clinical experience and scien@fic research will give CTSI- RAP alumni an all-encompassing perspec@ve on tackling health care challenges and conduc@ng clinical research. Abstract PI: Dr. Daniel Dumesic Background: Polycys@c Ovary Syndrome (PCOS) is an endocrine disorder that leads to the development of fluid-filled ovarian cysts, resul@ng in abnormally high quan@@es of male sex hormones. This imbalance leads to irregular menstrual cycles, pelvic pain, infer@lity, and insulin resistance, with associated long-term complica@ons including Type II diabetes, heart disease, and endometrial cancer. The purpose of this study is to u@lize diagnos@c informa@on to further characterize the effects of PCOS and compare them to the results of unaffected women. CTSI - RAP Involvement: CTSI-RAP students func@on as clinical coordinator assistants within the research study. Students conduct pa@ent screenings to determine study eligibility for prospec@ve par@cipants, audit and maintain pa@ent files, op@mize and conduct study par@cipant recruitment strategies, and observe and scribe for PCOS medical procedures. PI: Dr. Kara Calkins Background: The CUB research study looks for biomarkers in cord blood that may be indicators for hepa@c issues such as Nonalcoholic Faqy Liver Disease (NAFLD). 33% of children in the U.S. are classified as obese, and 38% of those children develop NAFLD, the leading cause for liver transplants in the US. Classifying babies at different gesta@onal ages may help evaluate risks of developing NAFLD. By analyzing the micro-RNA in the cord blood and studying the metabolomics of the individual, this study aims to see if these items are linked to higher suscep@bility to liver disease. CTSI - RAP Involvement: CTSI-RAP students contribute by screening pregnant mothers for a LGA (Large Gesta@onal Age), SGA (Small Gesta@onal Age), IUGR (Intrauterine Growth Restric@on), Obese, Overweight and/or Gesta@onal Diabetes label. When the pa@ent qualifies for the study, the RAP students proceed to the Labor and Delivery Unit of Ronald Reagan Hospital to consent the mothers before the baby is born. RAP students also par@cipate in cord blood collec@on, immediate blood processing, and maintaining pa@ent databases. Cord Umbilical Blood (CUB) Study PI: Dr. Igor Barjaktarevic Background: Shock is a common life-threatening condi@on that occurs in the ICU and early detec@on of shock is essen@al for decreasing mortality. The inadequate blood perfusion to vital organs associated with shock can lead to organ dysfunc@on and eventually cardiac arrest if not properly managed, which is usually with intravenous fluid (IV) administra@on or vasopressor medica@on. The purpose of this study is to determine whether systema@c inclusion of a bedside ultrasound protocol to evaluate fluid-responsiveness and iden@fy the e@ology of shock earlier in the hospital course significantly impacts clinical outcomes for pa@ents staying in the Intensive Care Unit (ICU). CTSI - RAP Involvement: On the medical and transplant ICU floors of Ronald Reagan Medical Center, CTSI-RAP students are trained to iden@fy and screen for prospec@ve pa@ents who are eligible to par@cipate in the study. Students communicate with eligible pa@ents to obtain their consent for par@cipa@ng in the study and answer any poten@al ques@ons the pa@ent might have. ABer enrolling a pa@ent in the study, students no@fy the principal inves@gator of the study. Shock Study PI: Dr. Jessica Wang Background: The ICDR aims to understand different factors influencing heart- related disease progression within affected families. Segrega@on analysis and the search for biomarkers within blood and @ssue samples provide a detailed picture of par@cipants' lifestyles before and during par@cipa@on in the ICDR. Resul@ng data will be sta@s@cally analyzed to beqer understand how gene@c and environmental factors influence disease manifesta@on. Collected samples may also be used to advance the understanding of disease mechanisms within families or disease condi@ons to uncover treatment op@ons in the future. CTSI - RAP Involvement: RAP students screen medical records and recruit pa@ents suitable for par@cipa@on in the study. ThereaBer, they gather consent for par@cipa@on from pa@ents of the UCLA Adult Congenital Cardiology Clinic as well as the Cardiac Care Unit (CCU) at Ronald Reagan Medical Center. Students also assist pa@ents to the pathology lab for blood collec@on and transport the samples for immediate processing. Furthermore, they work alongside Dr. Wang and a team of research specialists and gene@cs counselors to design and construct a comprehensive virtual database for the ICDR. Inherited Cardiovascular Disease Registry (ICDR) PolycysTc Ovary Syndrome (PCOS) Study Figure 1: Assets coated with copper/sham stainless steel Figure 3: Dr. Meeryo Choe performing a baseline concussion assesment CTSI-RAP Advisor: Dr. Laurie Ann Shaker-Irwin, Ph.D., M.S. Physician Advisor: Noah Carvajal Federman, M.D. Advisors Buckanavage, Jack ⧫ Cao, Quang ⧫ Dey, Ipsita ⧫ Dickson, Crystal ⧫ Dionson, Andrew ⧫ Ford, Victoria ⧫ Guan, Michelle ⧫ Habib, Omar ⧫ Ho, David ⧫ Jiang, Kelsey ⧫ Jones, Adrian ⧫ Lam, Harrison ⧫ Liu, Franklin ⧫ Jar-Yee, Liu ⧫ Lu, Mimi ⧫ McLaughlin, Ryan ⧫ Ng, Cassia ⧫ Nguyen, Kevin ⧫ Ong, Stephanie ⧫ Onggo,Stevyndnnis ⧫ Ringgenberg, ,Sienna ⧫ Sara, Afrida ⧫ So, Josh ⧫ Tran, Elizabeth ⧫ Wong, Shirley ⧫ Yao, Douglas ⧫ Yusuf, Hamzah CTSI-RAP Students 2016-2017 BrainSPORT, Copper Touch Rounds, CTRC Rounds, Depression Study, Methamphetamine Study, Brain-Gut Interac@ons in Obesity Study, and Systemic Lupus Erythematosus/Atherosclerosis Study AddiTonal Ongoing Projects Figure 2: Student filling out Fenton Growth Charts Figure 4: 4ICU Unit where the Shock and Copper Touch Study is conducted Acknowledgments: This research poster was funded by the CTSI through NCATS Grant No: UL1TR001881.
Transcript of CTSI Research Associates Program: Building Future Leaders ... · Poster Print Size: This poster...
Poster PrintSize:This poster template is 42” high by42” wide. Itcan be used to printanyposter with a1:1 aspectra@o.
Placeholders:ThevariouselementsincludedinthisposterareonesweoBenseeinmedical,research,[email protected],move,add,anddeleteitems,orchangethelayouttosuityourneeds.Alwayscheckwithyourconferenceorganizerforspecificrequirements.
ImageQuality:Youcanplacedigitalphotosorlogoartinyourposterfilebyselec@ngtheInsert,Picturecommand,orbyusingstandardcopy&paste.Forbestresults,allgraphicelementsshouldbeatleast150-200pixelsper inchintheir finalprintedsize.Forinstance,a1600x1200pixelphotowillusuallylookfineupto8“-10”wideonyourprintedposter.Topreviewtheprintqualityofimages,selectamagnifica@onof100%whenpreviewingyourposter.Thiswillgiveyouagoodideaofwhatitwilllooklikeinprint.Ifyouarelayingoutalargeposterandusinghalf-scaledimensions,besuretopreviewyourgraphicsat200%toseethemattheirfinalprintedsize.Pleasenotethatgraphicsfromwebsites(suchasthelogoonyourhospital'soruniversity'shomepage)willonlybe72dpiandnotsuitableforprin@ng.
[Thissidebarareadoesnotprint.]
ChangeColorTheme:Thistemplateisdesignedtousethebuilt-incolorthemesinthenewerversionsofPowerPoint.Tochangethecolortheme,selecttheDesigntab,thenselecttheColorsdrop-downlist.Thedefaultcolorthemeforthistemplateis“Office”,soyoucanalwaysreturntothataBertryingsomeofthealterna@ves.
Prin@ngYourPoster:Onceyourposterfileisready,visitwww.genigraphics.comtoorderahigh-quality,affordableposterprint.EveryorderreceivesafreedesignreviewandwecandeliverasfastasnextbusinessdaywithintheUSandCanada.Genigraphics®hasbeenproducingoutputfromPowerPoint®longerthananyoneintheindustry;da@ngbacktowhenwehelpedMicrosoB®designthePowerPoint®soBware.USandCanada:1-800-790-4001Email:[email protected]
[Thissidebarareadoesnotprint.]
CTSIResearchAssociatesProgram:BuildingFutureLeadersinClinicalResearch
KELSEYJIANG,STEVYDENNISONGGO,MICHELLEGUAN,JAR-YEELIU,NoahFederman,LaurieShaker-Irwin
UniversityofCalifornia,LosAngeles,LosAngeles,CA
The UCLA CTSI Research Associates Program (CTSI-RAP) aims toprovide UCLA undergraduate students with the opportunity togain exposure to hospital-based medicine as well as clinicalresearch. The program is designed to strengthen interest inbiomedical research ini@a@ves by allowing first-hand interac@onbetween UCLA faculty physicians and inves@gators withundergraduatestudents.Researchassociatesplayakeyroleintheimplementa@on of research protocols when they are given theopportunitytoassistprimaryinves@gatorswithvariousaspectsoftheir project including, but not limited to, consen@ng pa@ents,collec@ng secureddata, and co-authoring abstracts, posters, andpapers. In addi@on, students are given the opportunity tomakeroundswiththemedicalteam,observecommonprocedures,andexperience didac@c teaching sessions during the course of theirinvolvement in the program. Outside of direct researchexperience, the CTSI-RAP students are exposed to situa@onsmeanttoeducateandpreparethemforacareerinhealthcare.Asaresult, researchassociatesbecomecomfortablewiththe inner-workings of a hospital and gain skills in professionalism, pa@entcommunica@on,and researchmethodology.Theuniqueblendoffirst-handclinicalexperienceandscien@ficresearchwillgiveCTSI-RAP alumni an all-encompassing perspec@ve on tackling healthcarechallengesandconduc@ngclinicalresearch.
Abstract
PI:Dr.DanielDumesic
Background:Polycys@c Ovary Syndrome (PCOS) is an endocrine disorder thatleadstothedevelopmentoffluid-filledovariancysts,resul@ng inabnormallyhighquan@@esofmalesexhormones.Thisimbalanceleads to irregular menstrual cycles, pelvic pain, infer@lity, andinsulin resistance, with associated long-term complica@onsincludingTypeIIdiabetes,heartdisease,andendometrialcancer.The purpose of this study is to u@lize diagnos@c informa@on tofurthercharacterizetheeffectsofPCOSandcomparethemtotheresultsofunaffectedwomen.
CTSI-RAPInvolvement:
CTSI-RAPstudentsfunc@onasclinicalcoordinatorassistantswithinthe research study. Students conduct pa@ent screenings todeterminestudyeligibility forprospec@vepar@cipants,auditandmaintain pa@ent files, op@mize and conduct study par@cipantrecruitment strategies, andobserveand scribe forPCOSmedicalprocedures.
PI:Dr.KaraCalkins
Background:The CUB research study looks for biomarkers in cord blood thatmay be indicators for hepa@c issues such as Nonalcoholic FaqyLiverDisease(NAFLD).33%ofchildrenintheU.S.areclassifiedasobese, and 38% of those children develop NAFLD, the leadingcauseforlivertransplantsintheUS.Classifyingbabiesatdifferentgesta@onalagesmayhelpevaluaterisksofdevelopingNAFLD.Byanalyzing the micro-RNA in the cord blood and studying themetabolomics of the individual, this study aims to see if theseitemsarelinkedtohighersuscep@bilitytoliverdisease.
CTSI-RAPInvolvement:
CTSI-RAPstudentscontributebyscreeningpregnantmothersforaLGA (Large Gesta@onal Age), SGA (Small Gesta@onal Age), IUGR(Intrauterine Growth Restric@on), Obese, Overweight and/orGesta@onal Diabetes label. When the pa@ent qualifies for thestudy,theRAPstudentsproceedtotheLaborandDeliveryUnitofRonaldReaganHospitaltoconsentthemothersbeforethebabyisborn. RAP students also par@cipate in cord blood collec@on,immediatebloodprocessing,andmaintainingpa@entdatabases.
CordUmbilicalBlood(CUB)StudyPI:Dr.IgorBarjaktarevic
Background:Shock is a common life-threatening condi@on that occurs in theICU and early detec@on of shock is essen@al for decreasingmortality. The inadequate blood perfusion to vital organsassociated with shock can lead to organ dysfunc@on andeventuallycardiacarrestifnotproperlymanaged,whichisusuallywith intravenous fluid (IV) administra@on or vasopressormedica@on. The purpose of this study is to determine whethersystema@cinclusionofabedsideultrasoundprotocoltoevaluatefluid-responsiveness and iden@fy the e@ology of shock earlier inthe hospital course significantly impacts clinical outcomes forpa@entsstayingintheIntensiveCareUnit(ICU).
CTSI-RAPInvolvement:On the medical and transplant ICU floors of Ronald ReaganMedical Center, CTSI-RAP students are trained to iden@fy andscreen for prospec@vepa@entswho are eligible to par@cipate inthestudy.Studentscommunicatewitheligiblepa@ents toobtaintheir consent for par@cipa@ng in the study and answer anypoten@al ques@ons the pa@ent might have. ABer enrolling apa@ent in the study, students no@fy theprincipal inves@gator ofthestudy.
ShockStudy
PI:Dr.JessicaWang
Background:The ICDR aims to understand different factors influencing heart-related disease progressionwithin affected families. Segrega@onanalysis and the search for biomarkers within blood and @ssuesamplesprovideadetailedpictureofpar@cipants'lifestylesbeforeand during par@cipa@on in the ICDR. Resul@ng data will besta@s@cally analyzed to beqer understand how gene@c andenvironmental factors influence diseasemanifesta@on. Collectedsamples may also be used to advance the understanding ofdisease mechanisms within families or disease condi@ons touncovertreatmentop@onsinthefuture.
CTSI-RAPInvolvement:RAPstudentsscreenmedicalrecordsandrecruitpa@entssuitableforpar@[email protected],theygatherconsentforpar@cipa@on from pa@ents of the UCLA Adult CongenitalCardiologyClinicaswellastheCardiacCareUnit(CCU)atRonaldReagan Medical Center. Students also assist pa@ents to thepathology lab for blood collec@onand transport the samples forimmediate processing. Furthermore, they work alongside Dr.Wangandateamofresearchspecialistsandgene@cscounselorstodesignandconstructacomprehensivevirtualdatabasefortheICDR.
InheritedCardiovascularDiseaseRegistry(ICDR)
PolycysTcOvarySyndrome(PCOS)Study
Figure1:Assetscoatedwithcopper/shamstainlesssteel
Figure3:Dr.MeeryoChoeperformingabaselineconcussionassesment
CTSI-RAPAdvisor:Dr.LaurieAnnShaker-Irwin,Ph.D.,M.S.PhysicianAdvisor:NoahCarvajalFederman,M.D.
Advisors
Buckanavage, Jack⧫ Cao, Quang ⧫ Dey, Ipsita ⧫ Dickson, Crystal ⧫ Dionson,Andrew⧫Ford,Victoria⧫Guan,Michelle⧫Habib,Omar⧫ Ho, David ⧫ Jiang, Kelsey ⧫ Jones, Adrian ⧫ Lam, Harrison ⧫ Liu, Franklin⧫Jar-Yee,Liu⧫Lu,Mimi⧫McLaughlin,Ryan⧫Ng,Cassia⧫ Nguyen,Kevin⧫Ong,Stephanie⧫Onggo,Stevyndnnis⧫Ringgenberg, ,Sienna⧫Sara,Afrida⧫So,Josh⧫Tran,Elizabeth⧫Wong,Shirley⧫ Yao,Douglas⧫Yusuf,Hamzah
CTSI-RAPStudents2016-2017
BrainSPORT,CopperTouchRounds,CTRCRounds,DepressionStudy,MethamphetamineStudy,Brain-GutInterac@onsinObesityStudy,andSystemicLupusErythematosus/AtherosclerosisStudy
AddiTonalOngoingProjects
Figure2:StudentfillingoutFentonGrowthCharts
Figure4:4ICUUnitwheretheShockandCopper
TouchStudyisconducted
Acknowledgments:ThisresearchposterwasfundedbytheCTSIthroughNCATSGrantNo:UL1TR001881.
