CPIN Research Day 2014 - University of TorontoBooklet.pdf · 2014-04-05 · CPIN Research Day 2014...

CPIN Research Day2014

Meeting ProgramTuesday April 8, 2014Medical Sciences Building, University of Torontoand Mount Sinai Hospital Auditoriumhttp://neuroscience.utoronto.ca/events/CPIN_Research_Day.htm

Poster session and2014 International Symposium on Synaptic Plasticityand Brain Disorders, held in honour of Dr. John C. Roder

Collaborative Program in Neuroscience

Table of Contents

Schedule…………………………………………………………

Symposium details…………………………………………….

Dr. John C. Roder Biosketch………………………………...

Invited Speakers……………………………………………….

Event Organizers & Acknowledgements………………….

Poster Judges…………………………………………………. 5

CPIN Board of Directors & Committees………………….. 6

Poster Titles…………………………………………………….

Event Sponsors…………….………………………………….

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2014 CPIN Research Day and

International Symposium on Synaptic Plasticity and Brain Disorders

April 8, 2014

University of Toronto and Mount Sinai Hospital

Program Schedule

Research Day, Posters at Stone Lobby, MSB 9:00 Registration Poster Set-up 9:30 Welcome remarks: Dr. Zhong-Ping Feng (Director, CPIN) Poster evaluation announcement: Dr. Jeff Henderson (Chair, Poster Awards Committee)

Students’ Choice Awards: Dr. Lili-Naz Hazrati (Chair, Student’s Choice Poster Awards) 9:45 Poster presentation and evaluation 11:30 Poster Removal 12:00 Lunch at Mount Sinai Hospital, 600 University Avenue, 18th floor Auditorium lobby International Symposium on Synaptic Plasticity and Brain Disorders - Held in honour of the lifetime achievements of Dr. John C. Roder - Mount Sinai Hospital, Ben Sadowski 18th floor Auditorium 12:45 Opening remarks:

Dr. Jim Woodgett (Director, Lunenfeld-Tanenbaum Research Institute) Dr. Peter Lewis (Associate Vice-President, Research and Innovation, Univ. Toronto) Dr. Avrum Gotlieb (Interim Vice Dean, Graduate Education, Univ. Toronto) Dr. Stephen Matthews (Chair, Department of Physiology, Univ. Toronto)

Session A Chair: Dr. Lu-Yang Wang (Hospital for Sick Children, Toronto) 1:00 Dr. Jeffrey Henderson (Leslie Dan Faculty of Pharmacy, University of Toronto)

Regulation of programmed cell death: the CNS and beyond 1:30 Dr. Robert Gerlai (Department of Psychology, University of Toronto at Mississauga) Zebrafish, a novel neurobehavioural genetic tool for the analysis of fetal alcohol spectrum disorders

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2:00 Dr. Donglin Bai (Department of Physiology & Pharmacology, University of Western Ontario) Functional rescue of a CMTX-linked connexin mutant 2:30 Distinguished Neuroscience Lecture

Dr. Ana Martinez (Medicinal Chemistry Institute-CSIC, Madrid, Spain) From the lab to the bedside: targeting GSK-3 and PDE7 3:15 Coffee and juice break Session B Chair: Dr. Zhengping Jia (Hospital for Sick Children, Toronto) 3:30 Dr. Albert Wong (Centre for Addiction & Mental Health, Toronto) Disc1 as an entry point into the biology of mental illness 4:00 Dr. Michael Tymianski (Toronto Western Hospital, Toronto) Development of PSD95 inhibitors for the treatment of acute ischemic stroke 4:30 Dr. Michael Salter (Hospital for Sick Children, Toronto) Src regulation of NMDA receptors in pain and schizophrenia 5:00 Raymond & Beverly Sackler Distinguished Lecture

Introduction: Dr. Zhong-Ping Feng (Director, CPIN) Keynote Lecture / Sackler Distinguished Lecture Introduction: Dr. Michael Salter (Head, Neurosciences & Mental Health,Hospital for Sick Children)

Dr. Graham Collingridge (Centre for Synaptic Plasticity, University of Bristol, Bristol, UK) Memory Mechanisms in Health & Disease 6:00 Poster presentation awards announcement: Dr. Jeff Henderson and Dr. Lili-Naz Hazrati Closing remarks: Dr. Alison Buchan (Vice Dean, Research, Univ. Toronto) 6:15-7:00 Event Reception at Mount Sinai Hospital

Symposium Collaborative Sponsorship

The symposium was made possible by the support of The Lunenfeld-Tanenbaum Research Institute (Mount Sinai Hospital) and The University of Toronto Collaborative Program in Neuroscience (CPIN). We thank the Raymond and Beverly Sackler Foundation for their support of the Distinguished Lecture.

Honouring the achievements of Dr. John Roder

Dr. John C. RODER (Lunenfeld-Tanenbaum Research Institute and Univ. Toronto) http://www.lunenfeld.ca/researchers/roder The symposium is held in honour of Dr. Roder and is the featured event for the 2014 CPIN Research Day. Dr. Roder began his career as an Immunologist and later devoted his efforts in Neuroscience. He has devoted over 25 years to investigating the molecular processes underlying synaptic regulation and mental disorders. He has made major contributions to the field of synaptic plasticity and brain function. Dr. Roder is an accomplished mentor and has trained many exceptional researchers and educators, some of whom will be speaking at the event. This symposium will celebrate not only his academic successes and achievements, but also his leadership and mentorship.

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Dr. John Roder is a neuroscientist and Senior Investigator at the Lunenfeld-Tanenbaum Research Institute. He is also a Professor in the Departments of Molecular and Medical Genetics and Physiology at the University of Toronto. He is the holder of a Canada Research Chair in Learning and Memory. Dr. Roder’s research focuses on axonal and synaptic organization, their role in learning and memory and its impact on psychiatric disease. Dr. Roder has published more than 320 research articles, 75 reviews and book chapters and has mentored more than 90 graduate students and postdoctoral fellows. John was initially trained in immunology, receiving his Ph.D. in Bacteriology and Immunology in 1977 from The University of Western Ontario. Between 1977 and 1980, he performed postdoctoral work at the Max Planck Institute, Karolinska Institute, NIH, London University College, and Harvard. His work was key to the understanding the lineage and molecular regulation of new class of lymphocytes (NK, natural killer), critical factors in immune rejection. His work also directed new forms of human monoclonal antibody production. His laboratory is credited with the development of the embryonic stem cell line R1 in 1993, to this day a widely used stem cell line in murine stem cell transgenics.

John Roder’s first foray into neural functions included characterization of myelin associated glycoprotein (MAG), a key factor in maintaining myelin integrity. Work from the laboratory also demonstrated for the first time the inhibitory effects of MAG on mammalian CNS axon growth, clarifying mechanistically the greater inhibitory effects of CNS versus PNS myelin on axon outgrowth. His laboratory generated the first null mutants of MAG, as well as GluR2 (GluA2), mGluR4 and mGluR5 knockouts still in use today. In the area of synaptic signaling, Dr. Roder’s work highlighted the relationship between the above receptors and Src, calcineurin, and NCS-1 in synaptic plasticity and behaviour. Beginning in 2002 Dr. Roder’s laboratory began elucidating the role of hippocampal place cells in spatial memory via slice recordings and real time imaging of freely moving wildtype and genetically modified animals. During this period Dr. Roder established an ENU mutagenesis screening facility for learning and memory mutants instrumental in establishing several new mouse models of human behavioural and neurological disorders including ataxia, epilepsy, bipolar disorder, and alternating hemiplegia. A mouse reverse genetics approach was subsequently employed to screen for mutations in human psychiatric disorder candidate genes. The Roder lab made the first DISC1 mutants and continues to identify pharmacogenetic methods for reversing the symptoms and effects of devastating disorders including schizophrenia and depression.

Invited Speakers (in order of presentation)

Dr. Jeffrey HENDERSON (Leslie Dan Faculty of Pharmacy, Univ. of Toronto) http://phm.utoronto.ca/~jeffh/henderson.htm Dr. Henderson’s research is organized along three main themes: Post-mitochondrial regulation of programmed cell death (PCD) in the mammalian CNS; EphB-mediated control of neural connectivity in the CNS; and development and analysis of small molecule therapeutics to PCD. Dr. Henderson was a post-doctoral fellow in the Roder lab starting in 1990. Drs. Henderson and Roder continue to collaborate and have published 18 articles together. Dr. Robert GERLAI (Department of Psychology, Univ. of Toronto at Mississauga) http://www.csb.utoronto.ca/faculty/gerlai-robert Dr. Gerlai focuses on behaviour genetics, aiming to understand how genes influence brain function and behaviour. He employs zebra fish as a model system, using forward genetics screening to identify novel genes involved in learning and memory, social behaviours, and alcohol-related behaviours. Dr. Gerlai was a post-doctoral fellow in the Roder lab from 1991-1995. Dr. Donglin BAI (Dept. of Physiology and Pharmacology, Univ. of Western Ontario) http://www.uwo.ca/physpharm/faculty/bai_donglin.html Dr. Bai is interested in defining functional domains/residues of connexin molecules in gap junction channels and how gap junction mutants cause human diseases. He uses mutagenesis, dual patch clamp, and confocal fluorescent imaging techniques, as well as mouse models to study the functional defects of gap junction mutants. Dr. Donglin Bai was a post-doctoral fellow in the Roder lab from 1999 until 2002.

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Dr. Ana MARTINEZ (Medicinal Chemistry Institute-CSIC, Madrid, Spain) http://www.iqm.csic.es/paginas/neurogen%20drugs/personnel-AnaMartinez.html Dr. Martínez is a Research Professor with an organic chemistry background and interest on neurodegenerative disorders. She has lead projects on medicinal chemistry and rational drug design of new drugs for Alzheimer's and Parkinson's disease, amyotrophic lateral sclerosis, spinal cord trauma and multiple sclerosis. Active areas of research involve GSK-3 inhibitors, BACE inhibitors, PDE 7 inhibitors, neurogenic drugs, CK 1 inhibitors. Dr. Martínez has published an article with Dr. Roder and has ongoing collaborations.

Dr. Albert WONG (Centre for Addiction & Mental Health, and University of Toronto) http://www.pharmtox.utoronto.ca/faculty/directory/wong.htm Dr. Wong is interested in disease mechanisms in psychiatric illnesses like depression and schizophrenia. He uses animal models to investigate gene x environment interactions, epigenetics, transcription and neurodevelopment. Dr. Wong also studies human clinical samples and developed a VR environment to probe spatial navigation in schizophrenia patients. Dr. Wong was a summer student in Dr. Roder’s lab from 1989-1991, and Dr. Roder was the mentor for Dr. Wong’s CIHR Clinician-Scientist Fellowship. They have published 12 articles together, currently co-supervise a MD/PhD student and have several ongoing collaborations.

Dr. Michael TYMIANSKI (Toronto Western Hospital, and University of Toronto) www.uhnresearch.ca/researchers/profile.php?lookup=6066 Dr.Tymianski studies the cellular and molecular mechanisms of neuronal damage during stroke and other injuries such as epilepsy and trauma. His focus is on calcium-regulated signaling pathways that cause neurons to die when injured, aiming to design rational therapeutic strategies for neuronal injury. Dr. Tymianski was co-supersived by Drs. Roder and MacDonald during his MD/PhD in 1997-1999.

Dr. Michael SALTER (Hospital for Sick Children, Toronto, and Univ. of Toronto) http://www.sickkids.ca/AboutSickKids/Directory/People/S/Michael-Salter.html Dr. Salter studies how aberrations in molecular and cell-cell signaling cause nervous system disorders. He works on transmission, plasticity and signaling at glutamatergic synapses, studying biochemical processes that control the function and localization of NMDA receptors, in the context of neurodevelopmental disorders as well as chronic pain, epilepsy, and schizophrenia. Other work includes the role of microglia-neuron signaling in persistent pain hypersensitivity and primary sensory neuron interactions with the immune system. Dr. Salter was a post-doctoral fellow with Dr. Roder and Dr. Arthur Roach in 1988-89. Drs. Salter and Roder then collaborated in the 1990s and 2000s and have published 8 articles together. Dr. Graham COLLINGRIDGE (Centre for Synaptic Plasticity, Univ. of Bristol, UK) http://www.bristol.ac.uk/phys-pharm/people/graham-l-collingridge/overview.html Dr. Collingridge researches the molecular mechanisms of synaptic plasticity. He is interested in how glutamate receptors and their downstream effectors are involved in the mechanisms of long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus and other mammalian brain regions. By studying the molecular mechanisms of synaptic plasticity, he aims to understand learning and memory and their alteration in conditions such as Alzheimer’s and Parkinson’s disease, anxiety, stress, depression, schizophrenia, and epilepsy.

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Event Organizers & Acknowledgements

CPIN Research Day Organizing Committee Robert Chen Zhong-Ping Feng (Chair) Lili-Naz Hazrati Jeff Henderson Zhengping Jia Sonia Sugumar John Yeomans Lu-Yang Wang Suhail Asrar (CPIN Office) Symposium Organizing Committee Joe Culotti Zhong-Ping Feng John Georgiou Zhengping Jia Jeff Henderson CPIN Graduate Student Executives: Andrew Barszczyk Ceilidh Cunningham Katie Ferguson Vivek Mahadevan Denis Osipov Vladislav Sekulic Bhanu Sharma Luka Srejic Sonia Sugumar (Liaison) Sponsorships Joe Culotti Zhong-Ping Feng John Georgiou Lili-Naz Hazrati Zhengping Jia

Sackler Lecturer Invitation Zhengping Jia Poster Presentation Awards Zhong-Ping Feng Jeff Henderson (Chair) John Yeomans Student’s Choice Poster Awards Zhong-Ping Feng Lili-Naz Hazrati (Chair) Poster Site Coordinators Sonia Sugumar Suhail Asrar

Event Program Design Suhail AsrarJohn Georgiou Registration Desk CPIN Graduate Student Executives Suhail Asrar Chantal Lackan Photographers Suhail Asrar Isabelle Aubert Denis Osipov Hong-Shuo Sun Refreshments and Receptions Suhail Asrar Chantal Lackan Administration Suhail Asrar Chantal Lackan

Poster Judges

Isabelle Aubert Limor Avivi-Arber Zhong-Ping Feng Lili-Naz Hazrati Jeff Henderson Zheng Ping Jia Bill Ju Rebecca Laposa Julie L. Lefebvre

John Peever Stephen Perry Graham Pitcher Blake Richards Frances Skinner Shuzo Sugita Hong-Shuo Sun Kaori Takehara Arun Tiwari

Jane Topolovec-Vranic Douglas Tweed Kaviraj Udupa Amy Yang John Yeomans Jose Zariffa Karl Zabjek

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CPIN Board of Directors and Committees (2013 – 2014) The CPIN Board of Directors reviews and signs the Memorandum of Agreement (MoA) and oversees the general direction of the program.

• Lee Bartel (Music) • Katherine Berg (Rehabilitation Science)

• Heather Boon (Pharmaceutical Sciences) • Peter Burns (Medical Biophysics)

• Sven Dickinson (Computer Science)

• Harry Elsholtz (Laboratory Medicine and Pathobiology) • Zhong-Ping Feng (Chair, CPIN Director; Physiology)

• Avrum Gotlieb (Lead Faculty: Faculty of Medicine) • Allan Kaplan (Institute of Medical Science)

• Ernest Lam (Interim, Dentistry) • Stephen Matthews (Physiology) • Morris Moscovitch (Psychology)

• Justin Nodwell (Biochemistry)

• Lana Stermac (Applied Psychology and Human Development)

• Ulrich Tepass (Cell and Systems Biology) • Ruth Ross (Pharmacology) • Christopher Yip (Institute of Biomaterials and Biomedical Engineering)

The CPIN Academic Program Committee reviews admission and program requirements, program curriculum and completion, and program activities as per the MoA.

• Julie Audet (Institute of Biomaterials and

Biomedical Engineering)

• Lee Bartel (Music)

• Robert Chen (Institute of Medical Science)

• Jonathan O. Dostrovsky (Honorary member:

Physiology)

• Zhong-Ping Feng (Chair, CPIN Director)

• David R. Hampson (Honorary member:

Pharmaceutical Sciences) • Jeffrey Henderson (Pharmaceutical Sciences)

• Kang Lee (Applied Psychology and Human

Development) • Peter McPherson (Pharmacology)

• Angus McQuibban (Biochemistry) • John Peever (Cell and Systems Biology) • Janice Robertson (Laboratory Medicine and

Pathobiology)

• Ernest Lam (Interim, Dentistry) • Bojana Stefanovic (Medical Biophysics) • Martin Wojtowicz (Physiology) • John S. Yeomans (Psychology) • Karl Zabjek (Rehabilitation Science) • Richard Zemel (Computer Science)

The CPIN Executive Committee reviews and leads the program activities as per the MoA, including distinguished lectures, Research Day, outreach programs, sponsorships and faculty-student interactive events.

• Lee Bartel (Music)

• Oliver Ernst (Biochemistry)

• Zhong-Ping Feng (Chair, CPIN Director) • Lili-Naz Hazrati (Laboratory Medicine and

Pathobiology)

• Jeffrey Henderson (Pharmaceutical Sciences)

• Kang Lee (Human Development and Applied

Psychology) • Ofer Levi (Institute of Biomaterials and

Biomedical Engineering)

• John Peever (Cell and Systems Biology)

• Ruth Ross (Pharmacology & Toxicology) • Ernest Lam (Interim, Dentistry) • Bojana Stefanovic (Medical Biophysics) • Lu-Yang Wang (Physiology) • Albert Wong (Institute of Medical Science) • John S. Yeomans (Psychology)

• Karl Zabjek (Rehabilitation Science) • Richard Zemel (Computer Science) • CPIN Graduate Executives representative

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Poster Titles

Presenter: Elia Abi-Jaoude

Affiliation: Institute of Medical Science Supervisor: Paul Sandor D2/3 Dopamine Receptor (D2/3R) Availability in Unmedicated Adults with Tourette Syndrome Compared to Healthy

Controls: A [11C]Raclopride (RAC) and [11C]-(+)-Propyl-Hexahydro-Naphtho-Oxazin (PHNO) Positron Emission

Tomography Imaging Study

Abi-Jaoude E1, Segura B

2, Cho SS

3, Obeso I

4, Sandor P

1, Strafella AP

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1Department of Psychiatry, University Health Network, University of Toronto;

2Department of Psychiatry and Clinical Psychobiology, University of Barcelona;

3PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto;

4Institute of Cognitive Sciences, Centre National de la Recherche Scientifique, Lyon

Presenter: Sabrina Agnihotri

Affiliation: Department of Rehabilitation Science

Supervisor: Michelle Keightley

Autobiographical Memory Development and Social Cognition in Adolescents with Fetal Alcohol Spectrum Disorder

Agnihotri S1,2,3

; Cameron D1; Rasmussen C

4; Rovet J

2,5; Ryan J

5; Keightley M

1,3,5

1Graduate Department of Rehabilitation Sciences, University of Toronto;

2Department of Psychology, The Hospital for Sick Children;

3Bloorview Research Institute, Holland-Bloorview Kids Rehabilitation Hospital;

4Department of Pediatrics, University of Alberta;

5Department of Psychology, University of Toronto

Presenter: Rylan Allemang-Grand

Affiliation: Medical Biophysics

Supervisor: Jason Lerch

Perinatal environmental enrichment alters the trajectory of mouse brain development

Allemang-Grand R1,2

; Scholz J1; Langille E

1; & Lerch JP

1,2

1Mouse Imaging Centre, Toronto, Ontario

2Department of Medical Biophysics, University of Toronto

Presenter: Andrew Barszczyk

Affiliation: Physiology

Supervisor: Zhong-Ping Feng

A cell-permeable caltubin peptide is cytoprotective and enhances neurite outgrowth in vitro by calcium-dependent

stabilization of microtubules

Barszczyk AM1; Deurloo M

1; Turlova E

1,2; Lee J

3; Sun H-S

1,2; and Feng, Z-P

1

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1Department of Physiology, University of Toronto;

2Department of Surgery, University of Toronto;

3Department of Laboratory Medicine and Pathobiology, University of Toronto

Presenter: Pieter Beerepoot

Affiliation: Pharmacology

Supervisor: Ali Salahpour

Pharmacological chaperoning of monoamine transporters by the dopamine/norepinephrine transporter blocker

bupropion

Beerepoot P; Salahpour A

Department of Pharmacology & Toxicology, University of Toronto

Presenter: Marie Kristel Bermejo

Affiliation: Pharmacology & Toxicology


Characterization of mitochondrial function in animals over-expressing the dopamine transporter

Bermejo MK1; Andreazza AC

1,2,3, Salahpour A

1

1Department of Pharmacology & Toxicology;

2Department of Psychiatry;

3Centre for Addiction & Mental Health

Presenter: Vanessa Breton


Supervisor: Peter Carlen

Epileptogenic transitions in excitatory and inhibitory postsynaptic currents in in vitro human neocortical seizures

Breton VL,1,2

, Dian JA,1,5

, Valiante TA,1,4

, Carlen PL, 1,2,3

1Division of Fundamental Neurobiology, Toronto Western Research Institute;


3Division of Neurology, Department of Medicine;

4Division of Neurosurgery, Department of Medicine;

5Department of Electrical and Computer Engineering, University of Toronto;

Presenter: Monique Budani

Affiliation: Laboratory Medicine and Pathobiology

Supervisor: Cliff Lingwood

Towards Identification of Glucosyl Ceramide Flippase in Glycosphingolipid Biosynthesis

Budani M1,3

, Mylvaganam M3, Binnington B

3, Lingwood C

1,2,3

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1Department of Laboratory Medicine and Pathobiology, University of Toronto;

2Department of Biochemistry, University of Toronto;

3Division of Molecular Structure and Function, Research Institute, Hospital for Sick Children

Presenter: Fernando Caravaggio

Affiliation: Institute of Medical Science

Supervisor: Ariel Graff-Guerrero

Reduced insulin sensitivity is related to less endogenous dopamine at D2/3 receptors in the ventral striatum of

healthy non obese humans: Preliminary findings with [11C]-(+)-PHNO

Caravaggio F1,2

; Borlido C2; Hahn M

1,2; Raitsin S

1,2; Plitman E

1,2; Nakajima S

2; Gerretsen P

1,2; Wilson A

1,2; Remington G

1,2;

Graff-Guerrero A1,2

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1Institute of Medical Science, University of Toronto;

2Research Imaging Centre, Centre for Addiction & Mental Health

Presenter: Annik Carson

Affiliation: Cell and Systems Biology

Supervisor: Melanie Woodin

A Dynamic Model of the Potassium Chloride Co-transporter KCC2 in Regulating Efficacy of Inhibitory

Neurotransmission

Yalnizyan-Carson A1, Guerguiev J

1, Doyon N

2, Pressey J

1, Mahadevan V

1, Richards B

3, Woodin, M

1

1Cell and Systems Biology, University of Toronto;

2Division of Cellular and Molecular Neuroscience, Centre de Recherche Université Laval Robert-Giffard;

3Department of Biological Sciences, University of Toronto Scarborough

Presenter: Robin Cash

Affiliation: Division of Brain, Imaging and Behaviour Systems Neuroscience, TWRI

Supervisor: Robert Chen

Competing mechanisms underlying Paired Associative Stimulation

R. Cash, G. Jegatheeswaran, Z. Ni, R. Chen

Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, Ontario, Cana

Presenter: Hsin-Yi Chao

Affiliation: Department of Psychology/University of Toronto

Supervisor: John M. Kennedy

Front, Left, and Impossible Response Alternatives on the Piaget 3-Mountains Task

Chao HY; Kennedy JM; Wnuczko M

Department of Psychology, University of Toronto

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Presenter: Yuxiao Chen

Affiliation: Department of Pharmacology and Toxicology

Supervisor: Amy J. Ramsey

Improving BDNF signalling to improve cognitive deficits of NMDA receptor mutant mice

Chen, Y; Milenkovic, M; Ramsey, AJ;

Department of Pharmacology and Toxicology, University of Toronto

Presenter: Jun ku Chung


Supervisor: Ariel Graff

Grey matter volume predicts accurate response rate in patients with mild cognitive impairment and older controls

during a working memory task

Chung J2,3

, Burhan AM4, Graff-Guerrero A

1,2,3

1Department of Psychiatry, University of Toronto;


3The Centre for Addiction and Mental Health, Research Imaging Group, Toronto, Ontario, Canada;

4Division of Geriatric Psychiatry, University of Western Ontario

Presenter: Ceilidh Cunningham


Supervisor: Lu-Yang Wang/William Trimble

Mechanisms of septin 5-mediated inhibition of neurotransmitter release

Ceilidh Cunningham1,3

, William Reginold3, Carol Froese

3, Lu-Yang Wang

1,4, William Trimble

1,2,3

1Departments of Physiology,University of Toronto, Ontario, Canada

2Department of Biochemistry, University of Toronto, Ontario, Canada

3Programs in Cell Biology, The Hospital for Sick Children, Ontario, Canada

4Neurosciences and Mental Health, The Hospital for Sick Children, Ontario, Canada

Presenter: Marielle Deurloo


Supervisor: Zhong-Ping Feng

Copy Number of the General Transcription Factor (Gtf2i) Determines Neuronal Maturation in Williams-Beuren

Syndrome Model through the TRPC3 channel

Deurloo H.S. Marielle1, Tam Elaine

2,3, Sun Hong-Shuo

1,4, Osborne Lucy R

2,3 Zhong-Ping Feng

1

1Department of Physiology, University of Toronto

2Department of Medicine, University of Toronto

3Department of Molecular Genetics, University of Toronto

4Department of Surgery, University of Toronto

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Presenter: Ayan Dey


Supervisor: Brian Levine

Functional neuroimaging of cerebral small vessel disease: feasibility of simultaneous fMRI-EEG data acquisition

Dey AK1,2,4

, Turner G1,4

, Black SE1,2,3,4

, Levine B1,2

1University of Toronto

2Rotman Research Institute, Baycrest Hospital

3LC Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre

4Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre

Presenter: Chesarahmia Dojo Soeandy

Affiliation: Department of Pharmaceutical Sciences, University of Toronto

Supervisor: Jeffrey Henderson

Enhanced Model of Cerebral Ischemia: Focal Vasoconstriction via Endothelin-1

Dojo Soeandy C, Salmasi F, He C; Cai P, Wu S, Henderson J

Department of Pharmaceutical Sciences, University of Toronto

Presenter: Benjamin Dunkley

Affiliation: Department of Diagnostic Imaging, The Hospital for Sick Children

Supervisor: Margot J. Taylor

Resting-state functional connectivity in post-traumatic stress disorder: an MEG study

Dunkley, B. T.1,2

, Doesburg, S. M.1,2,3,4

, Sedge, P. A.5, Grodecki, R. J.

6, Shek, P.N.

7, Pang, E. W.

2,8, Taylor, M. J.

1,2,3,4

1Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada

2Neuroscience & Mental Health Program, The Hospital for Sick Children Research Institute, Toronto, Canada

3Department of Medical Imaging, University of Toronto, Toronto, Canada

4Department of Psychology, University of Toronto, Toronto, Canada

5Directorate of Mental Health, Canadian Forces Health Services, Ottawa, Canada

6Canadian Forces Environmental Medicine Establishment, Toronto, Canada

7Defence Research and Development Canada, Toronto, Canada

8Division of Neurology, The Hospital for Sick Children, Toronto, Canada

Presenter: Shane Ellis


Supervisor: William Hutchison

Stimulation-Induced Theta Oscillations in GPi of Patients with Parkinson's Disease

Ellis, Shane1; Lopez Rios A

2; Kalia SK

3; Hodaie M

3; Lozano AM

2;Hutchison WD

1,3

1Department of Physiology, Faculty of Medicine, University of Toronto;

2Division of Neurosurgery, Department of Surgery, University Hospital San Visente;

3Division of Neurosurgery, Department of Surgery, Toronto Western Hospital

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Presenter: Katie Ferguson


Supervisor: Frances K. Skinner

Sharp transitions of gamma coherence in inhibitory networks occur when a biological context and constraints are

imposed

Ferguson KA1,2

; Huh CYL3; Amilhon B

3; Williams S

3; Skinner FK

1,4,2

1Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada

2Physiology, University of Toronto, Toronto, Ontario, Canada

3Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada

4Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada

Presenter: Roxana Florica

Affiliation: Chemistry and Biology/Ryerson University

Roles of ENU-3 in neuronal axon guidance in Caenorhabditis elegans

Florica R

Biology & Chemistry, Ryerson University

Presenter: Trehani Fonseka


Supervisor: Sidney Kennedy

The Role of Immune Genes in Antipsychotic-Induced Weight Gain

Trehani M. Fonseka1,2,3

;Arun K. Tiwari1;Natalie Freeman

1;Jeffrey A. Lieberman

4;Herbert Y. Meltzer

5;James L. Kennedy

1,

Sidney H. Kennedy3, Daniel J. Müller

1

1Pharmacogenetics Research Clinic, Neuroscience Department, Centre for Addiction and Mental Health & Department of

Psychiatry, University of Toronto, Toronto, ON, CA 2Institute of Medical Sciences, University of Toronto, Toronto, ON, CA

3Department of Psychiatry, University Health Network, University of Toronto, Toronto, ON, CA

4Department of Psychiatry, College of Physicians and Surgeons, Columbia University and the New York State Psychiatric

Institute, New York City, NY, USA 5Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Presenter: Sabiha Gardezi


Supervisor: Elise F. Stanley

THE ROLE OF CAV2.2 C-TERMINUS IN CALCIUM CHANNEL ANCHORING AT THE PRESYNAPTIC TRANSMITTER

RELEASE SITES

Gardezi SR1,2

, Li Q,2, Stanley EF

1,2

1Physiology

2Krembil Discovery Tower at Toronto Western Hospital

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Presenter: Jacqueline Gleave

Affiliation: Biological Sciences

Supervisor: Joanne Nash

The Role of SIRT3 as a Disease Modifying Agent in Parkinson’s Disease

Gleave, JA1, Lizal, K

1, Yong-Kee, C

1, Brotchie, J

2, Koprich, J

2, Eubanks, J

2, Nash, JE

1

1Department of Biological Sciences, Centre for the Neurobiology of Stress, University of Toronto Scarborough, Toronto, ON,

M1C 1A4, Canada; 2Toronto Western Research Institute, Toronto, ON M5T 2S8, Canada

Presenter: Alexandre Guet-McCreight


Supervisor: Frances Skinner

Modeling interneuron-specific (IS) interneurons in hippocampus

Guet-McCreight A1,2

, Camiré O3, Topolnik L

3, Skinner F

1,4,2

1Toronto Western Research Institute, University Health Network;

2Physiology, University of Toronto;

3Biochemistry, Microbiology and Bioinformatics, Université Laval;

4Medicine (Neurology), University of Toronto;

Presenter: Axel Guskjolen

Affiliation: Physiology/Sick Kids Hospital

Supervisor: Paul Frankland

Infantile Amnesia: Infant Mice Lack Spatial Memory Persistence

Guskjolen, A.J.1,2

, Josselyn, S.A.1,2,3,4

, and Frankland, P.W.1,2,3,4

1Program in Neurosciences and Mental Health, The Hospital for Sick Children;




Presenter: Sean Haffey


Supervisor: Beverley Orser

A role for astrocytes in the persistent enhancement of GABAA receptor activity following acute exposure to

anesthetics

Haffey SC1; Zurek AA

1; Lecker I

1; Penna A

1; Wang DS

1; Orser BA

1,2,3.

1Department of Physiology,

2Department of Anesthesia, University of Toronto, Toronto, Ontario M5S-1A8, Canada;

3Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada;

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Presenter: Stefanie Hutka

Affiliation: Department of Psychology

Supervisor: Sylvain Moreno

On the neural responses underlying bidirectionality of music-to-language transfer

Hutka, S1,2

; Bidelman, GM3,4

; Moreno, S1,2

1Rotman Research Institute at Baycrest;

2Department of Psychology, University of Toronto;

3Institute for Intelligent Systems, University of Memphis;

4School of Communication Sciences and Disorders, University of Memphis

Presenter: Paul Hwang

Affiliation: UTERP, OBI-EpLink, Paediatrics & Medicine

The Canadian Experience with Perampanel, an AMPA-receptor antagonist: real-life experience over 5 years for

partial-onset epilepsy

Pillay Neelan1, Hwang Paul A

2, MacLachlan Richard

3

1Epilepsy Programme, University of Calgary;

2University of Toronto Epilepsy Research program, EpLink-OBI, Depts. Paediatrics & Medicne, NYGH, U of Toronto

3Epilepsy program, London Health Sciences Centre, Western University;

Presenter: Reina Isayama

Affiliation: Institute of Medical Science IMS


Assessment of Sensorimotor Integration Pathway during an Illusory Multi-sensory Perception

Isayama R.1,2

, Jegatheeswaran G.1,2

, Vesia M.1,2

, Elahi B.2, Cardinali L.3,4

, Farne A.3, Chen R.

1,2

1Institute of Medical Science, University of Toronto

2Division of Brain, Imaging and Behavior - Systems Neuroscience, Toronto Western Research Institute

3Lyon Neuroscience Research Center, Lyon

4The Brain and Mind Institute, University of Western Ontario, London, ON

Presenter: Gaayathiri Jegatheeswaran



The roles of agency and ownership in the rubber hand illusion

Jegatheeswaran G1,2

; Isayama, R1,2

; Vesia, M2; Elahi, B

1,2; Chen, R

1,2

1Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada;

2Division of Neurology and Krembil Neuroscience Centre, Toronto Western Research Institute, University Health Network,

Toronto, Ontario, Canada

15

Presenter: Jason Jia

Affiliation: McMaster University; Department of Psychology, University of Toronto Mississauga

Supervisor: Robert Gerlai

Studying sociability and social memory using the zebrafish as a model system

Jia, J1,2

, Fernandes, Y3, Gerlai, R

2,3

1McMaster University;

2Department of Psychology, University of Toronto Mississauga;

3Department of Cell and Systems Biology, University of Toronto

Presenter: Aaron Kucyi


Supervisor: Karen Davis

Mind wandering away from pain dynamically engages antinociceptive and default mode brain networks

Aaron Kucyi1,2

, Tim V. Salomons1,3

, Karen D. Davis1,2,4,5

1Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, University Health

Network; 2Institute of Medical Science, University of Toronto;


4Division of Neurosurgery, Toronto Western Hospital;

5Department of Surgery, University Health Network, Toronto, ON, Canada

Presenter: Vincent Lam

Affiliation: Pharmacology & Toxicology


TAAR1 as a new Target for Treatment of Parkinson's Disease: The Discovery of Novel Chemical Compounds

Through the use of in silico Screening and in vivo Testing

Lam VM1, Zhang T

1, Koh EJ

1, Mielnik CA

1, Carlsson J

2, and Salahpour A

1

1Department of Pharmacology and Toxicology, University of Toronto

2Department of Biochemistry and Biophysics, University of Stockholm, Science for Life Laboratory, Solna, Sweden

Presenter: Celeste Leung


Supervisor: Zhengping Jia

The role of PAK signaling in synaptic transmission and plasticity using a tetracycline inducible system in mice

Leung C1,2

, Zhang SP2, Jia ZP

1,2

1Department of Physiology, Faculty of Medicine, University of Toronto

2Neurosciences and Mental Health, Hospital for Sick Children

16

Presenter: Victoria Lishak

Affiliation: Applied Psychology and Human Development, OISE

Supervisor: Katreena Scott, Kang Lee

Neural and Behavioural Changes on a GoNogo Task Following Working Memory Treatment

Lishak,V1, Liu,Z

2, Woltering,S

1, Tannock

1

1Applied Psychology and Human Development,OISE, University of Toronto


Presenter: Zhongxu Liu

Affiliation: Applied Psychology and Human Development

Supervisor: Morris Moscovitch

Cognitive-training effects on EEG Beta power during working memory maintenance in adults with ADHD

Liu, Z.-X.1, 2

,Woltering, S.1, Glizer, D.

1, & Tannock, R

1, 3

1Department of Applied Psychology & Human Development, OISE, University of Toronto

2Rotman research institute in Baycrest hospital

3Hospital for Sickkids

Presenter: Chelsea Lowther


Supervisor: Anne Bassett

Copy Number Variations Adults Dual Diagnosed with Schizophrenia and Intellectual Disability

Lowther C1; Stavropoulos DJ2; Lionel C3; Marshall CR

3; Scherer SW

3; Bassett AS

1,4

1Institute of Medical Science, University of Toronto, Toronto, Ontario

2Cytogenetics Laboratory, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada

3The Center for Applied Genomics and Program in Genomics and Genome Biology, The Hospital for Sick Children, Toronto,

Ontario, Canada 4Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

Presenter: Samantha Mahabir



A Strain Comparison of Zebrafish Shoaling Behaviour

Mahabir S1; Chatterjee D

2; Gerlai R

1,2

1Department of Cell and Systems Biology, University of Toronto;

2Department of Psychology, University of Toronto Mississauga

17

Presenter: Vivek Mahadevan


Supervisor: Melanie A. Woodin

Regulation of native-KCC2 function and chloride homeostasis by components of excitatory neurotransmission

Vivek Mahadevan1; Jessica C. Pressey

1; Brooke A. Acton

1; Michelle Y. Huang

1; Jonah Chevrier

1; Evgueni A. Ivakine

2; Eric

Delpire3; Roderick R. McInnes

2,4; Melanie A. Woodin

1

1Department of Cell & Systems Biology, University of Toronto, Canada;

2Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Canada;

3Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, USA;

4Lady Davis Research Institute, Jewish General Hospital, McGill University, Canada

Presenter: Josiane Mapplebeck


Supervisor: Michael Salter

SEX DIFFERENCES IN THE SPINAL MECHANISMS UNDERLYING NEUROPATHIC PAIN IN MICE

Mapplebeck JCS1, 3

, Sorge RE2, Martin LJ

3, Alexander J

1, Beggs S

1, Rosen S

3, Zhang J

4, Mogil JS

3, Salter MW

1


2Department of Psychology, University of Alabama at Birmingham;

3Department of Psychology, McGill University;

4Faculty of Dentistry, McGill University;

Presenter: Victoria McCutcheon

Affiliation: Institute of Medical Sciences

Supervisor: Andrew Baker

Development and validation of two zebrafish models of TBI

McCutcheon V1, Park E

2, Liu E

2, Tavakkoli J

3, SobheBidari P

3, Baker AJ

1,2,4

1Institute of Medical Sciences, University of Toronto;

2Keenan Research Centre in the Li Ka Shing Knowledge Institute at St. Michael’s Hospital;

3Department of Physics, Ryerson University;

4Departments of Anesthesia & Surgery, University of Toronto;

Presenter: Katherine McDonald

Affiliation: Department of Psychology, York University

A Dance Intervention for People with Parkinson’s Disease: Investigating Short-Term and Long-Term Impacts of

Dance on Physical Functioning and Quality of Life

McDonald, K.M.1, Bar, R.J.

4,5; DeSouza, J.F.X.

1,2,3

1Department of Psychology, York University;

2Department of Biology, York University;

3Centre for Vision Research, York University;

4Department of Psychology, Ryerson University;

5Canada's National Ballet School;

18

Presenter: Mohadeseh Mehrabian


Supervisor: Gerold Schmitt-Ulms

The cellular prion protein contributes to EMT

Mohadeseh Mehrabian1,2

, Dylan Brethour1,2

, Jin Kyu Kim1, Zhengrui Xi

1, Christine Sato

1, Sepehr Ehsani

1,2, Ekaterina

Rogaeva1,3

, Gerold Schmitt-Ulms1,2

1Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5T 2S8, Canada;

2Department of Laboratory Medicine and Pathobiology,

3Department of Medicine, University of Toronto, Toronto, Ontario M5S1A8, Canada;

Presenter: Lia Mesbah-Oskui

Affiliation: Medicine

Supervisor: John C. Roder

Impaired Place Cell Spatial Selectivity and Inhibitory Neuron Function in Disc1 Mutant Mice

Lia Mesbah-Oskui1, 3, 4

, John C. Roder1, 2, 4


2Molecular Genetics, University of Toronto;

3Medicine, University of Toronto;

4Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital;

Presenter: Catharine Mielnik

Affiliation: Pharmacology and Toxicology

Supervisor: Amy Ramsey

Inducible rescue of NMDA receptor deficiency; plasticity of neural networks

Mielnik CA, Horsfall, W, Ramsey, AJ

Department of Pharmacology & Toxicology, University of Toronto

Presenter: Nikolaos Mitrousis

Affiliation: Institute of Biomaterials and Biomedical Engineering

Supervisor: Molly Shoichet

Using bioengineering to investigate retinal photoreceptor development for the treatment of retinal degeneration

Nikolaos Mitrousis1, Roger Y Tam

1,2, Derek van der Kooy

3,4, Molly S Shoichet

1,2,3,5

1Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto;

2Department of Chemical Engineering and Applied Chemistry, University of Toronto;


4Department of Molecular Genetics, University of Toronto;

5Department of Chemistry, University of Toronto;

19

Presenter: Ho-Suk Mun

Affiliation: Molecular Genetics


BRAIN REGIONS ACTIVATED BY EXPLORATION THAT AUGUMENTS SPATIAL LEARNING AND MEMORY

Ho-suk Mun1,2

, Bechara J. Saab1,2,3

, John C. Roder1,2

1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada

2Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada

3Brain Research Institute, University of Zürich, Zürich 8057-CH, Switzerland

Presenter: Enoch Ng

Affiliation: Institute of Medical Science / Lunenfeld Tanenbaum Research Institute


Knockout of Neuronal calcium sensor-1 in mice decreases operant responding and delays habit formation

Ng E1, Hermainski J

2, Pongs O

2, Wong AHC

3, Roder JC

4


2University of Hamburg;

3Department of Pharmacology, University of Toronto;

4Department of Molecular Genetics, University of Toronto

Presenter: Christina Nona

Affiliation: Pharmacology and Toxicology

Supervisor: Jose Nobrega

Altered dendritic spine morphology in mice showing resistance to ethanol sensitization

Nona, CN, Nobrega JN

Behavioural Neurobiology Research Section, Centre for Addiction and Mental Health, Toronto, Ontario

Presenter: Hyemin Oh


Supervisor: Lucy Osborne

Effects of GTF2I copy number on neural stem cell maintenance in the developing mouse cortex

Oh HM1, Osborne L

1,2


2Department of Molecular Genetics, University of Toronto;

20

Presenter: Shraddha Pai

Affiliation: Centre for Addiction and Mental Health

Supervisor: Arturas Petronis

Cortical and sperm epigenomes in bipolar disorder

Pai S1, Labrie V

1, Groot,D

2, Carlucci,M

2, Petronis A

1,3

1Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health;

2University of Waterloo;


Presenter: Antonello Penna

Affiliation: Department of Physiology, University of Toronto


Hydrogen peroxide increases a tonic GABA current in hippocampal neurons

Penna A1, Wang DS

1, Yu J

1, Lecker I

1, Orser B

1,2,3


2Department of Anesthesia, University of Toronto;

3Department of Anesthesia, Sunnybrook Health Sciences Centre

Presenter: Eric Plitman


Supervisor: Ariel Graff-Guerrero

Higher striatal glutamate is related to grey matter loss: preliminary findings in antipsychotic-naïve patients with first

episode schizophrenia

Plitman E1,2

, De la Fuente C3,4

, Chakravarty M5, Chung J

1,2, Gerretsen P

1,2, León-Ortiz P

3, Remington G

6, Graff-Guerrero A

1

1Multimodal Neuroimaging Schizophrenia Group, Research Imaging Centre and Geriatric Mental Health Division, Centre for

Addiction and Mental Health & Department of Psychiatry, University of Toronto, Canada; 2Institute of Medical Science, University of Toronto, Toronto, Canada;

3Experimental Psychiatry Laboratory, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico;

4Neuropsychiatry Department, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico;

5The Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental

Health; 6Schizophrenia Program, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto, Canada;

Presenter: Sofia Raitsin


Supervisor: Jeffrey Meyer

Effects of Glucocorticoids and Oxidative Stress on Monoamine Oxidase A (MAO-A) Activity in the Prefrontal Cortex

in Rodents: Implications for Major Depressive Disorder (MDD)

Raitsin S1,2

, Tong J1,3

, Kish S1,4

, Xu X2, Magomedova L

5, Cummins C

5, Meyer J

1,2,3,4

21


2Research Imaging Centre and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health;


4Department of Pharmacology, University of Toronto;

5Leslie Dan Faculty of Pharmacy, University of Toronto;

Presenter: Rageen Rajendram


Supervisor: Paul Arnold

Identification of Rare Genetic Variants in OCD Using Extended Pedigrees

Rajendram R1,2

, Li B2, Richter MA

4, Kennedy JL

5, Marshall C

2, Hanna GL

3, Arnold PD

1,2


2The Hospital for Sick Children;

3University of Michigan;

4Sunnybrook Health Sciences Centre;

5Centre for Addiction and Mental Health;

Presenter: Gabriela Rozanski


Supervisor: Elise F. Stanley

LOW VOLTAGE-ACTIVATED CALCIUM CHANNELS GATE TRANSMITTER RELEASE AT THE DORSAL ROOT

GANGLION SANDWICH SYNAPSE

Rozanski GM1,2

, Nath AR1,2

, Adams ME3, Stanley EF

1,2

1Laboratory of Synaptic Transmission, Genetics and Development, Toronto Western Research Institute;


3Cell Biology & Neuroscience, University of California Riverside

Presenter: Derya Sargin


Supervisor: Evelyn Lambe

Mice with compromised 5-HTT function lack phosphotyrosine-mediated inhibitory control over prefrontal 5-HT

responses

Sargin D1, Goodfellow NM

1, Lambe EK

1,2


2Obstetrics and Gynaecology, University of Toronto

22

Presenter: Ner Mu Nar Saw


Supervisor: Zhengping Jia

DISRUPTED-IN-SCHIZOPHRENIA 1(DISC1) AND Ras-related C3 botulinum toxin substrate 1 (RAC1) SIGNALING IN

SYNAPTIC PLASTICITY AND COGNITION

Saw, NMN1,3

, Zhang, SP3, Meng, Y

3, Gao, X, and Jia, ZP

1,2,3


2Department of Medicine, Faculty of Medicine, University of Toronto;

3Department of Neurosciences and Mental Health, Hospital for Sick Children

Presenter: Vladislav Sekulic


Supervisor: Frances K. Skinner

Conductances are co-regulated in hippocampal oriens-lacunosum/moleculare (O-LM) interneurons: an ensemble

modeling analysis

Sekulic V1,2

, Lawrence JJ4,5

, Skinner FK1,3,2

1Toronto Western Research Institute, University Health Network;


3Department of Medicine (Neurology), University of Toronto;

4Department of Biomedical and Pharmaceutical Sciences, University of Montana;

5NIH COBRE Center for Structural and Functional Neuroscience, University of Montana

Presenter: Soaleha Shams

Affiliation: Cell & Systems Biology


Effect of social deprivation on response to social stimuli and neurochemistry in adult zebrafish

S. Shams1, N, Chatterjee2, R. Gerlai1,2

1Cell & Systems Biology Dept.;

2Psychology Dept; University of Toronto Mississauga

Presenter: Bhanu Sharma

Affiliation: Graduate Department of Rehabilitation Science

Supervisor: Robin Green

Feasibility and preliminary efficacy of an online cognitive training program for moderate-to-severe traumatic brain

injury

Bhanu Sharma1,2

, Jennifer C. Tomaszczyk1, Brenda Colella

1, Greg Noack

1, Robin Green

1,2

1Toronto Rehabilitation Institute;

2University of Toronto, Graduate Department of Rehabilitation Science

23

Presenter: Sanjana Shellikeri

Affiliation: Speech Language Pathology

Supervisor: Yana Yunusova

Articulatory Compensation in Amyotrophic Lateral Sclerosis: Tongue and Jaw in Speech

Shellikeri S1, Yunusova Y

1,2, Green J

3,4, Zinman L

1,2

1University of Toronto;

2Sunnybrook Research Institute;

3Institute for Health Professions, Massachusetts General Hospital;

4Nebraska Medical Center

Presenter: Vanessa Sinopoli


Supervisor: Paul Arnold

Association between 5-HTTLPR variant and hoarding traits in a population-based pediatric sample

Sinopoli V1,2

, Dupuis A2

, Burton C1,2

, Crosbie J1,2

, Shan J2, Schachar R

1,2, Arnold P

1,2

1University of Toronto

2The Hospital for Sick Children

Presenter: Luka Srejic


Supervisor: William Hutchison

High Frequency Stimulation of the Medial Prefrontal Cortex affects Serotonin in the Dorsal Raphe

Srejic LR1, Wood KM

2, Hashemi P

2, Hutchison WD

1,3

1Institute of Medical Science, University of Toronto, Toronto, ON;

2Wayne State University, Detroit, MI;

3Department of Neurosurgery, Toronto Western Hospital, Toronto, ON

Presenter: Dushyaan Sri Renganathan


Supervisor: Anurag Tandon

A strategy to measure alpha-synuclein aggregation as an in vitro model for Parkinson’s disease pathology

Sri Renganathan D, Samuel F, Giassi AC, Fraser PE, Tandon A

Centre for Research in Neurodegenerative Diseases, University of Toronto

Presenter: Morrison Steel

Affiliation: The Hospital for Sick Children

Supervisor: Karen Gordon

Measuring Binaural Integration in Children

Steel MM1, Papsin BC

1,2, Gordon KA

1,2

24

1Archie's Cochlear Implant Laboratory, Department of Otolaryngology, The Hospital for Sick Children;

2Department of Otolaryngology - Head and Neck Surgery and Institute of Medical Sciences, Faculty of Medicine, University of

Toronto

Presenter: Gregory Szilagyi


Supervisor: Sandra E. Black

Predicting conversion from Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD) using FDG-PET textural

feature measures

Szilagyi GM1,2

, Black SE1,2,3

, Soucy JP4, Caldwell CB

5,6

1Institute of Medical Science, Faculty of Medicine, University of Toronto;

2L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute;

3Brain Sciences Research Program, Sunnybrook Research Institute;

4McConnell Brain Imaging Centre, Montreal Neurological Institute;

5Department of Medical Imaging, Sunnybrook Health Sciences Centre;

6Departments of Medical Imaging and Medical Biophysics, University of Toronto;

Presenter: Nicolas Theodoric

Affiliation: Neurosciences and Mental Health

Supervisor: Sheena Josselyn

Effect of fear memory activation on interpretation bias

Theodoric N1,2

, Taliaz D2; Gonzalez S

3, Mai M

2, Josselyn SA

1,2


2Program in Neurosciences and Mental Health, Hospital for Sick Children;

3Instituto de Neurobiología, Universidad Nacional Autónoma de México

Presenter: Steven Tran



Dopamine D1 and D2/3 receptor antagonism differentially alters zebrafish motor patterns

Tran S1,3

, Nowicki M2, Muraleetharan A

2, Chatterjee D

2, Gerlai R

1,2,3

1Department of Cell and Systems Biology, University of Toronto;

2Department of Psychology, University of Toronto at Mississauga;

3Collaborative Program in Neuroscience, University of Toronto

25

Presenter: Anup Tuladhar

Affiliation: Institute of Biomaterials and Biomedical Engineering

Supervisor: Molly Shoichet

Local delivery of cyclosporine to the brain for endogenous neural stem cell stimulation after stroke

Tuladhar A1, Shoichet MS1,2,3

1Institute of Biomaterials and Biomedical Engineering, University of Toronto;

2Department of Chemical Engineering and Applied Chemistry, University of Toronto;

3Department of Chemistry, University of Toronto;

4Donnelly Centre for Cellular and Biomolecular Research;

Presenter: Ekaterina Turlova


Supervisor: Hong-Shuo Sun

Volume-regulated anion channel blockade in hypoxic neuronal injury

Turlova E1, Zhao L

3, Alibrahim A

1,2, Wang GL

3, Sun HS

1,2


2Department of Surgery, Faculty of Medicine, University of Toronto;

3Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

Presenter: Kaviraja Udupa

Affiliation: Division of Neurology, Dept of Medicine, University of Toronto


Motor cortical plasticity in Parkinson's disease assessed by transcranial magnetic stimulation

Udupa K, Chen R

Division of Neurology and Toronto Western Research Institute, Division of Brain, Imaging and Behaviour - Systems

Neuroscience, University of Toronto

Presenter: Ellen van der Plas

Affiliation: Psychiatry Research

Supervisor: Russell Schachar

Autism spectrum disorder, response inhibition, ADHD traits, and obsessive compulsive behaviors in a community

sample

van der Plas E1,2

, Dupuis A3,4

, Shan J1, Crosbie J

1,2, Schachar R

1,2

1The Department of Psychiatry, the Hospital for Sick Children

2The Department of Psychiatry, the University of Toronto

3Dalla Lana School of Public Health

4Biostatistics, Design & Analysis, Hospital for Sick Children

26

Presenter: Danielle Weber-Adrian


Supervisor: Isabelle Aubert

MRI-guided Focused Ultrasound use in Gene Delivery to the Spinal Cord

Weber-Adrian D1,2

, Thévenot E1,2

, O'Reilly MA3,4

, Oakden W3,4

, Akens MK5, Ellens N

3,4, Markham K

1, Finkelstein J

6, Yee

AJM7, Whyne CM

7, Foust KD

8, Kaspar BK

8, Chopra R

9, Hynynen K

3,4, Aubert I

1,2

1Brain Sciences Research, Biological Sciences, Sunnybrook Research Institute, Toronto, ON Canada;

2Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada;

3Imaging Research, Sunnybrook Research Institute, Toronto, ON, Canada;

4Department of Medical Biophysics, Toronto, ON, Canada;

5TECHNA Institute, University Health Network, Toronto, ON Canada;

6The Spine Program, Division of Orthopaedic Surgery, Sunnybrook Research Institute, Toronto, ON Canada;

7Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, Toronto, ON Canada;

8Department of Neuroscience, Ohio State University and Center for Gene Therapy, The Research Institute at Nationwide

Children's Hospital, Columbus, OH, USA; 9Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA

Presenter: Nikolaus Wolter

Affiliation: Institute of Medical Sciences

Supervisor: Karen Gordon

Objective Measurements of Balance in Children with Cochleovestibular Loss

Wolter NE1,2,3

, Cushing SL2,3

, Vilchez-Madrigal LD2,3

, Papsin BP1,2,3

, Gordon KA1,2,3

1University of Toronto Institute of Medical Sciences;

2University of Toronto, Department of Otolaryngology - Head & Neck Surgery;

3Hospital for Sick Children, Archie's Cochlear Implant Lab

Presenter: Angelita Wong

Affiliation: Psychology

Supervisor: Tomas Paus

Social context and the maturation of pituitary gland during adolescence

Wong APY1,2

, Ewing SF3, Bryan A

4, Pipitone J

5, Park MTM

5, Dickie EM

1, Leonard G

6, Perron M

7,8, Pike B

9, Richer L

7,

Veillette S7,8

, Chakravarty MM1,2,5

, Pausova Z10

, Paus T1,2

1Rotman Research Institute - Baycrest, Toronto, Canada;

2University of Toronto, Toronto, Canada;

3University of New Mexico, Albuquerque, NM;

4University of Colorado, Boulder, CO;

5Kimel Family Translational Imaging- Genetics Laboratory, Centre for Addiction and Mental Health, Toronto, Canada;

6Montreal Neurological Institute, McGill University, Montreal, Quebec;

7 ni ersit du u ec Chicouti i Chicouti i u ec;

8 C S C gep de on ui re on ui re Canada;

9University of Calgary, Calgary, Alberta;

10The Hospital for Sick Children, Toronto, Canada;

27

Presenter: Frances Xia


Supervisor: Paul Frankland

The role of parvalbumin-positive interneurons in memory consolidation

Xia F1,2

, Richards BA3, Santoro A

1,4, Josselyn SA

1,2,4,5, Frankland PW

1,2,4,5

1Neurosciences & Mental Health, Hospital for Sick Children;


3Department of Biological Sciences, University of Toronto Scarborough;


5Department of Psychology, University of Toronto;

Presenter: Annette Ye


Supervisor: Margot Taylor

Magnetoencephalography Reveals Altered Functional Brain Network Connectivity In Children Born Very Preterm

Ye AX1,2,3,4

, Aucoin-Power MA1,2

, Taylor MJ1,2,3,4

, Doesburg, SM1,2,3,4

1Neuroscience and Mental Health, Hospital for Sick Children Research Institute;

2Diagnostic Imaging, Hospital for Sick Children;

3Institute for Medical Science, University of Toronto;

4Collaborative Program in Neuroscience, University of Toronto;

Presenter: Dorothy Zhao

Affiliation: Molecular Genetics

Supervisor: Jack F. Greenblatt

Termination Control by an RNA Polymerase II CTD R1810me2s-SMN Interaction

Dorothy Yanling Zhao1,2,3

, Gerald Gish2, Yue Li

4, Guoqing Zhong

1, Jinrong Min

5, Masoud Vedadi

5, Jason Moffat

1,3, Tony

Pawson2,3

, Jack F. Greenblatt1,3

1Donnelly Centre and Banting & Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1,

Canada 2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada

3Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada

4Department of Computer Science, The Donnelly Centre, University of Toronto, Toronto, ON M5S 3G4, Canada

5Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada

Presenter: Agnieszka Zurek



Anesthetics cause a sustained increase in extrasynaptic GABA(A) receptor activity and memory deficits

Zurek AA1, Yu J

1, Wang D

1, Bridgwater E

1, Orser BA

1,2,3

1Department of Physiology, University of Toronto, Toronto, ON, Canada;

2Department of Anesthesia, University of Toronto, Toronto, ON, Canada;

3Department of Anesthesia, Sunnybrook Health Sciences Centre, Toronto, ON, Canada;

56

Event Sponsors

Raymond and Beverly Sackler Foundation

CPIN Research Day 2014 - University of TorontoBooklet.pdf · 2014-04-05 · CPIN Research Day 2014...

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