COEN 180 Erasure Correcting, Error Detecting, and Error Correcting Codes.
Correcting false discovery rates for their bias toward ... · Correcting false discovery rates for...
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Correcting false discovery rates for their bias toward false positives
2017 Annual Meeting of the Statistical Society of Canada University of Manitoba, Winnipeg
13 June 2017
David Bickel University of Ottawa
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Swung too far?
Family-wise error ratesToo many false negatives
False discovery ratesToo many false positives
Local false discovery ratesLarge variance
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The rise of false discovery rates
• Desktop software:
• GSEA
• Cyber-T
• MACS
• Web software:
• DAVID
• Toppfunn
• GREAT
Why the FDR became popular
FDR software used in genomics
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Multiple comparisons
D. R. Bickel, Statistical Applications in Genetics and Molecular Biology 12, 529–543
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FDRs & local FDRs
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Achieved FDR
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Bias in false discovery rates
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Correcting the bias
D. R. Bickel, deposited in uO Research at https://goo.gl/GcUjJe
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Re-ranked FDRs
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Biomedical data
D. R. Bickel, deposited in uO Research at https://goo.gl/GcUjJe
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Gene expression data
D. R. Bickel, deposited in uO Research at https://goo.gl/GcUjJe
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The right balance
Family-wise error ratesToo many false negatives
False discovery ratesToo many false positives
CFDR RFDR
Other local FDR estimators?
Slides and preprint: www.davidbickel.com
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Acknowledgements • Collaborators:
• Alexandre Blais
• Abbas Rahal
• Funding:
• Agriculture and Agri-Food Canada
• Faculty of Medicine of the University of Ottawa