Leadership Presentation atNuclear Suppliers Workshop

Coquí Pharma

Oak Ridge, TN2 October, 2018

Carmen Bigles Coquí CEO & President

Introduction

“Only a life lived for others is a life worthwhile”

~ Albert Einstein ~

The impact of having a sustainable supply of medical radioisotopes particularly Mo-99 will advance medicine.

Coquí’s mission is to create a commercially scalable and reliable supply of medical diagnostic and therapeutic

radioisotopes in the US using proven technology

2October 2018

Nuclear Reactors to Healthcare

COMPANY CONFIDENTIAL 3

Mo-99 is an essential part of modern nuclear medicine• Mo-99’s (Molybdenum-99) decay product, Technetium-99m (Tc-99m) is utilized in over 80% of all

SPECT nuclear medicine procedures, it is the world’s most widely used medical radioisotope

• Annually over 18 million procedures in the United States utilize Mo-99 (most Myocardial perfusion studies)

• Mostly produced from weapons grade U-235 (i.e., Highly Enriched Uranium or HEU)

• USA is the largest global Consumer yet no domestic manufacturing capability

U235 in Reactor for irradiation

Mo99 Separated & Purified

Tc99m

GeneratorRadiopharmacy Patient

October 2018

The Coquí Solution

COMPANY CONFIDENTIAL 4

• Proven 10MW Nuclear Reactor from INVAP Exclusive license for USA from INVAP: the world’s leading designer

and developer of LEU Mo-99 production facilities CNEA Mo-99 Technology OPAL in Australia, Egypt, Argentina, Algeria & Netherlands* All Low Enriched Uranium (LEU)

• Proven FDA approved LEU Mo-99 process Meet >50% of USA Medical Demand 50% domestic and 50% export

• Coquí Project $500M CAPEX facility 1,500 construction jobs 150 permanent high-tech jobs Nuclear collaborative opportunities with ORNL U-235 for target plates & fuel assemblies from Y-12 Future Heritage Center Airport

October 2018

The Ideal Site for Coqui

Criteria

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USA Nuclear Centre of Excellence

Strong nuclear talent pool

Nuclear strategic- collaborative opportunities & partnerships

Understanding nuclear friendly community

Supply of U-235 for Fuel & Targets

Nuclear waste processing capability

Emergency & Hazmat Services

Airport close by

Security perimeter with one access point…. an island

October 2018

Strategic Site Location - I

The Coquí to be strategically located at Oak Ridge, Tennessee

6October 2018

Strategic Site Location - II

ETTP & Heritage Center

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• Oak Ridge (1942) comprised Y-12, S-50, K-25 & X-10 facilities and was known as the Manhattan Project

• Used to produce enriched Uranium using the gaseous diffusion method at K-25

• Today Oak Ridge hosts one of the largest National Labs for Science & Energy in the USA

• Original home of some medical radioisotopes

• Nuclear Technology Park• Former Manhattan Site• Heritage Center

• Strategic location for Coquí Centre for USA Nuclear Excellence Nuclear collaborative opportunities Understanding nuclear friendly community Strong nuclear talent pool Nuclear waste processing Y-12 for Fuel & Targets Emergency & Hazmat Services Proactive Economic Development community

October 2018

Strategic Site Location - III

Coqui’s new home at Oak Ridge

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• Duct Island

• 206 Acres Greenfield site

• 101,337 SqFt (2.3 Acres)

• Road, air & water access

• Geotechnical surveys by DOE

• Water security perimeter

• Multiple electricity sources

• TVA SMR neighbour

Strategic Site Location - IV

Proposed Airport at Oak Ridge

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• Minutes from Duct Island

• 5,000 foot runway

• Suitable for Type A & Type B(U) transport containers

• $35-40M

• Operational in 2022

• Gross Margin advantage due to close proximity

• Awaiting approval by FAA

• Backup: RKW (30 mins) & TYS (42 mins)

www.oakridgeairport.org

October 2018

Breaking News……

Coqui’s new home is now a reality………..

10October 2018

Thank You

October 2018 11

World class team

National Critical Infrastructure

Proven Technology

Oak Ridge

The specific discussions herein about our company include financial projections and

future estimates and expectations about the company’s business. The projections,

estimates, and expectations are presented only as a guide about future possibilities

and do not represent actual amounts or assured events. All the projections and

estimates are based exclusively on our company management’s own assessment of

its business, the industry in which it works, the economy at large, and other

operational factors, including capital resources and liquidity, financial condition,

fulfillment of contracts, and opportunities. Potential investors should not make an

investment decision based solely on our company’s projections, estimates, or

expectations.

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