COPD i COPD

PM2.5

COPD

PAE

PAE PAE

‒1‒

PAE pediatric allergy educatior

/

A 5 ATS-DLD

inhaled corticosteroid :ICSNO FeNO

PAE 1PAE FeNO

B 15 C

2009 2018 10 91 6

AD FA5

3 1

A

31

B PM2.5

‒2‒

A4 8

CISAAC

TDSFTND

A

100

B 15 2003 2008 6 72009 2012 3

6 1.5 2 AD22 23 AD 10 5 AR 1319 AC 5 FA

6 FA 10

‒3‒

SPMC 381 353

AD FA6

FA BA AD

1 3 21

3JPAC

3

FAAD

‒4‒

30 10September Exacerbation 1 3

3 4

A

3110

1 1TEL 052-972-2690

HP

2 3

1…

…

…

28

JPACNO

0

20

40

60

80

100

1 - 5

5 - 20

20 -

(307) (34) (76) (127) (71) (49)

P = 0.003

NS

P < 0.001

P < 0.0000001

NS

(ng/ mg creatinine)

(%)

20092

664

2011. 6. 4. 28 2

4-6

10 5

720202019

4-62021

‒5‒

B PM2.5A4 8

4000 31

C811 748 631

257 41 1 217142 65

TDSFTND

1 44 TDS, FTND FTND

28 12141 17

636 2

TDS FTND

FTND

n = 142 n = 75 n = 142 n = 75

P > 0.9 P = 0.01TDS FTND

FTND Q1

0%

20%

40%

60%

80%

100%

56-30

31-60

60

100

80

60

40

20

0

(%)

( )

P = 0.008

‒6‒

A10

B

6.6

8

5.84.9

7.7

2.8

0

1

2

3

4

5

6

7

8

9

1 2

3.8

8.7

5.3

2.5

8.2

3.3

0

1

2

3

4

5

6

7

8

9

10

1 2

1 1613 2 13441 1751 2 1443

1 BA AD FA 7,8,6

0%20%

40%60%

80%100%

45.5

50

50

100

54.5

50

50

0

‒7‒

31

••••

••

‒8‒

A

B

C 2

31

A

B 15 2008 AD AD AR AC FA FA

SPM C

A

B PM2.5

C

‒9‒

A

B

A

B

C 15 AD AR

D 1 6 1

IgE 1 AR

IgE

ACT FeNO

A

‒10‒

B

EIAEIA

A 100

B 15

AD 22 23 AD 10 5 AR 1319 AC FA FASPM C

FA BA AD

A

10

B PM2.5 A4 8

4000 C 41

TDSFTND

FTND 63 6

2

A

‒11‒

B

BA AD FA

1

PM2.5

‒12‒

1 Hausnuma H, Yamazaki S, Tamura K, Hwang YH, Ono R, Amimoto Y, Askew DJ, Odajima H:

Association between daily ambient air pollution and respiratory symptoms in children with asthma and healthy children in western Japan. J Asthma.2018;8:1-7. 2

2017 28 1 46-51

3

2018 32 1 136-143 4

(R)2017 15 3 382-386

52017 30 2 29-35 6 201730 1 45-50 7 2017 3 256 27-29 82017 28 1 52-57 9 10 2017 24 1012-23 10 11 2017 24 1158-63 11 38 5 38-41 2018

‒13‒

122016

32 2 303-312 2018 13 ,

68-72. 2017 14

68-71. 2018 15 . 1-Day .

30(3): 498-498, 2016. 16 . .

15(2): 328-328, 2017.

1

60(12) 1641-1645,2011 2

2010 37-43,2012

1 54 2017 1118-19 2

66 2017 6 16-18 3

66 2017 6 16-18

4 NO34 2017 7 22-23

5 16 2018 218 6 PM2.5 24

2017 10 3 7

28 3 2017 2 22 8 29 20174 11 9

‒14‒

2017 5 2 10

2017 8 22 11 201710 16 12

67 2018 6 22-24 13

35 2018 7 28-29 14 David Askew

592018 9 12-14

15 Odajima H, Shimomura G, Akamine Y, Ninomiya T, Murakami Y, Motomura C, Honjo S, Factors influencing the course of asthma from the 1st to 6th grade of elementary school, the 26th World Congress of Asthma, Tokyo Japan, Oct 3-6, 2018 16 Shimomura G, Odajima H, Useful of the indices of peripheral airway in the study of Bronchial reactivity, the 26th World Congress of Asthma, Tokyo Japan, Oct 3-6, 2018 17 Ninomiya T, Shimomura G, Akamine Y, Murakami Y, Motomura C, Honjo S, Odajima H The Effect of Spirometry on the Stability of Exhaled Nitric Oxide in Daily Practice in Asthmatic Children, Tokyo Japan, Oct 3-6, 2018 18 , , , , , , ,

: 72017.2

19 , , , 120 2017.4

20 , , , : 3 66 2017.6 21 , , , , , , ,

, , , , , , , ,

? 54 2017.11 22 , ,

54 2017.11 23 , ,

. 8 2018.2

‒15‒