COORDINATED RESEARCH ACTIVITIES...COORDINATED RESEARCH ACTIVITIES - NAHU BUDGET - 2014 Programme/...

COORDINATED RESEARCH ACTIVITIES

Alfredo PoloInternational Atomic Energy Agency

Vienna, Austria

COORDINATED RESEARCH ACTIVITIES REPRESENT A SIGNIFICANT COMPONENT OF THE IAEA OPERATIONS

Radiotracer technologies

Prevention of cardiovascular disease and diabetes

Seafood Safety

Nuclear forensics

cour

tesy

of A

NST

O

Radioactive waste

Managing irrigation water

Radiation processing

Water security

Combating animal diseases

Sterile insect technique

Cancer treatment

Environmental monitoring

Seawater desalination

How to participate, as a research institution, in

Search for relevant CRPs that are open for List of IAEA Coordinated Research Activities by Major Programme, Programme and Project that are Open for Submission of Proposals;

Submit a Proposal for Research Contract or Agreement directly to the IAEA’s Research Contracts Administration Section, using the form template on the IAEA web site (preferably via

cra.iaea.org

The IAEA's Coordinated Research ActivitiesUniting the World through Research

The IAEA brings together research institutions

across the globe to collaborate in nuclear science

projects ranging from isotopes and radiation

applications in agriculture, human health, industry,

hydrology and terrestrial and marine environment to

nuclear energy and economic studies and nuclear

safety and security.

IAEA coordinated research activities (CRAs)

encourage both the acquisition and the

dissemination of new knowledge and technology

generated through the use of nuclear technologies

and isotopic techniques, as well as the adaptation

of these technologies in IAEA Member States.

Results of CRAs are disseminated to Member

States and the international scientific community

through publications and via IAEA technical

cooperation projects, under which CRA findings

are often applied practically.

The CRAs are implemented primarily via

coordinated research projects (CRPs) and their

related Research Coordination Meetings (RCMs).

Each CRP typically brings together 10–15 research

institutions from a range of countries at different

stages of socioeconomic development, which work

together. Research is conducted in the participating

institutions, with the IAEA coordinating the work

and organizing periodic RCMs, with CRPs designed

to contribute to building professional relationships

and networks which thrive beyond the lifetime of

the CRP.

How to participate, as a research institution, in

coordinated research activities:

Go to cra.iaea.org

9 Search for relevant CRPs that are open for

submission of proposals using:

• List of IAEA Coordinated Research Activities

by Major Programme, Programme and Project

that are Open for Submission of Proposals;

• CRP search.

9 Submit a Proposal for Research Contract or

Agreement directly to the IAEA’s Research

Contracts Administration Section, using the form

template on the IAEA web site (preferably via

email).

¾

¾CRA at a glance

¾ 120 active CRPs

¾ 1600 research institutions involved through research, technical and doctoral contracts or research agreements

¾ 70 RCMs organized per year

¾ €7 million annual budget

The International Atomic Energy Agency (IAEA) is authorized under its Statute to encourage and assist research on atomic energy for peaceful uses throughout the world as well as on its development and practical applications. The IAEA’s programme and budget for 2015 accordingly provide for the placing of research, technical and doctoral contracts and research agreements with universities, colleges, research centres, and laboratories, and other institutions in Member States on subjects directly related to the IAEA’s work.

• CRPs are developed to solve well-‐defined

research topics in which an appropriate

number of institutes (10-‐15) are invited to

collaborate

• CRPs have proven to be an effective means

of bringing together researchers from both

developing and industrialised countries to

solve a problem of common interest

COORDINATED RESEARCH ACTIVITIESCOORDINATED RESEARCH PROJECTS (CRPs)

Participate in multinational research

Provide answer to a relevant scientific question

Improve routine clinical practice

75% 25%

NAHU Other

ACTIVE CRPs AT THE END OF 2014

125 Active CRPs 73 RCMs

TOTAL


NAHU

DISTRIBUTION OF CRPs

75% 25%

NAHU Other

ACTIVE CRPs AT THE END OF 2014


TOTAL


NAHU

NAHRES 8

NMDI 7

ARBR 11

DMRP 5

DISTRIBUTION OF CRPs IN NAHU

0

5

10

15

20

25

30

35

40

2000 2002 2004 2006 2008 2010 2012 2014

TEMPORAL EVOLUTION OF CRPsTOTAL NUMBER OF CRPs (NAHU)

Source: IAEA (anual reports) http://cra.iaea.org/cra/cra-resources/annual-reports.html

http://cra.iaea.org/cra/cra-resources/annual-reports.html

0

10

20

30

40

2000 2002 2004 2006 2008 2010 2012 2014

NAHRES NMDI ARBR DMRP

TEMPORAL EVOLUTION OF CRPsTOTAL NUMBER OF CRPs (NAHU)



75% 25%

NAHU Other

ACTIVE CRAs AT THE END OF 2014

EUR 6.778.111

TOTAL

EUR 1.721.293

NAHU

DISTRIBUTION OF BUDGET

0 M €

1 M €

2 M €

3 M €

4 M €

5 M €

6 M €

7 M €

8 M €

2000 2002 2004 2006 2008 2010 2012 2014

TEMPORAL EVOLUTION OF BUDGETPERIOD 2000-2014



0 M €

1 M €

2 M €

3 M €

4 M €

5 M €

6 M €

7 M €

8 M €

2000 2002 2004 2006 2008 2010 2012 2014

Total CRA budget NAHU budget






2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014

Total budget 7,13 6,44 6,45 7,00 7,00 7,39 5,75 6,60 6,61 6,67 7,10 6,71 7,16 7,55 6,77

NAHU budget 1,57 1,55 1,39 1,71 1,49 1,81 1,40 1,73 1,90 2,06 2,03 1,46 1,58 1,84 1,72

In million €


COORDINATED RESEARCH ACTIVITIES - NAHU BUDGET - 2014

Programme/Project

Research contracts Technical contracts Doctoral contractsCRP

purchases Total €RCM

Overall total €No. Amount € No. Amount € No. Amount € No. Amount €

2000004 8 40000 40000 8 40008

2000010 18 185450 5 46500 14 155000 386950 49 70087 457037

2000015 58 359000 6 67500 89947 516447 29 53617 570064

2000024 46 238356 5 48000 286356 41 70974 357330

2000029 11 47600 2 10000 57600 57600

2000042 31 139189 139189 67 100065 239254

Sub-total 172 1009595 16 162000 16 165000 89947 1426542 186 294751 1721293

NAHU BUDGET - 2014


17,12%

5,23%

9,59%

9,41%

58,65%

Research contracts Technical contracts Doctoral contracts CRP purchases RCM

NAHU BUDGET - 2014


HOW CLINICAL RESEARCH IS CONDUCTED AT IAEA

DIFFERENT TYPES OF CRA SUPPORTED BY IAEA

WHY IS CLINICAL RESEARCH IMPORTANT FOR IAEA?

Clinical research funding is aligned with the mandate to the IAEA to encourage and assist research on atomic energy for peaceful uses

throughout the world as well as on its development and

practical applications.

Funding research to improve health globally delivers on the

IAEA commitment to international development

while also exploring research questions of relevance that would be difficult to address

otherwise. CRA is instrumental to build capacity in

methodological research in Member States

Funding clinical research activities reinforce the

leadership of IAEA in key areas of human health as cancer

control, nutrition and cardiovascular diseases.

Disseminating these activities will increase awareness and

increase access to this programme

Clinical Research at IAEA contributes to tackle the implementation of the

Sustainable Development Goals making IAEA a

trustworthy player in the Public Health community

Non-Communicable-Diseases have become a priority in

Global Health, but there is a significant gap in the

international agenda. IAEA has built a substantial Global

Health portfolio contributing with 1.7M€ per year to clinical research. In this way IAEA can

become a key player in the WHO NCD Action Plan

NAHU DIRECTOR

SH-NMDISH-ARBRSH-DMRPSH-NAHRES

HOW NAHU CONDUCTS CLINICAL RESEARCH

TO TO TO TO TO TO TO TO TO TO TO TO TO TO TO TO

CRP

DIRECTOR’S OFFICE

• Selection of topic to be included in P&B

• Formulation and Submission of Detailed Proposals for New CRPs

• Announcement of Approved New CRPs

• Submission of Research, Technical and Doctoral Contract and Agreement Proposals

• Evaluation of Research Proposals and Selection of CRP Participants

• Research, Technical and Doctoral Contracts and Research Agreements

• Preparation of Contracts and Agreements

• Funding of the Coordinated Research Activities

• Research Coordination Meetings (RCMs) 1-‐2-‐3 (+ reporting)

• Review of CRPs Evaluation of Completed CRPs

• Publication of CRP Results

COORDINATED RESEARCH PROJECTSTHE BASIC PROCESS OF A CRP

COORDINATED RESEARCH PROJECTSGEOGRAPHICAL DISTRIBUTION -‐ NAHU PROJECTS -‐ ACTIVE

COORDINATED RESEARCH PROJECTSGEOGRAPHICAL DISTRIBUTION -‐ ARBR PROJECTS -‐ ACTIVE

SOME PUBLISHED RESULTS• Jeremic B, Fidarova E, Sharma V et al. The International Atomic Energy Agency (IAEA) randomized trial of palliative treatment of incurable locally advanced non small cell

lung cancer (NSCLC) using radiotherapy (RT) and chemotherapy (CHT) in limited resource setting. Radiother Oncol. 2015;116:21-26.!• Hassan Metwally MA, Ali R, Kuddu M et al. Radiotherapy quality assurance of the IAEA-HypoX trial of the accelerated radiotherapy in the treatment of head and neck

squamous cell carcinoma with or without the hypoxic radiosensitizer nimorazole. Acta Oncol. 20151-4.!• Hassan Metwally MA, Ali R, Kuddu M et al. IAEA-HypoX. A randomized multicenter study of the hypoxic radiosensitizer nimorazole concomitant with accelerated

radiotherapy in head and neck squamous cell carcinoma. Radiother Oncol. 2015;116:15-20.!• Hoskin P, Rojas A, Fidarova E et al. IAEA randomised trial of optimal single dose radiotherapy in the treatment of painful bone metastases. Radiother Oncol.

2015;116:10-14.!• Rosenblatt E, Abdel-Wahab M, El-Gantiry M et al. Brachytherapy boost in loco-regionally advanced nasopharyngeal carcinoma: a prospective randomized trial of the

International Atomic Energy Agency. Radiat Oncol. 2014;9:67.!• Overgaard J, Mohanti BK, Begum N et al. Five versus six fractions of radiotherapy per week for squamous-cell carcinoma of the head and neck (IAEA-ACC study): a

randomised, multicentre trial. Lancet Oncol. 2010!• Rosenblatt E, Jones G, Sur RK et al. Adding external beam to intra-luminal brachytherapy improves palliation in obstructive squamous cell oesophageal cancer: a

prospective multi-centre randomized trial of the International Atomic Energy Agency. Radiother Oncol. 2010;97:488-494.!• Dobrowsky W, Huigol NG, Jayatilake RS et al. AK-2123 (Sanazol) as a radiation sensitizer in the treatment of stage III cervical cancer: results of an IAEA multicentre

randomised trial. Radiother Oncol. 2007;82:24-29.!• Vasanthan A, Mitsumori M, Park JH et al. Regional hyperthermia combined with radiotherapy for uterine cervical cancers: a multi-institutional prospective randomized trial

of the international atomic energy agency. Int J Radiat Oncol Biol Phys. 2005;61:145-153.!• Grau C, Prakash Agarwal J, Jabeen K et al. Radiotherapy with or without mitomycin c in the treatment of locally advanced head and neck cancer: results of the IAEA

multicentre randomised trial. Radiother Oncol. 2003;67:17-26.!• Salazar OM, Sandhu T, da Motta NW et al. Fractionated half-body irradiation (HBI) for the rapid palliation of widespread, symptomatic, metastatic bone disease: a

randomized Phase III trial of the International Atomic Energy Agency (IAEA). Int J Radiat Oncol Biol Phys. 2001;50:765-775.

Vasanthan A, Mitsumori M, Park JH et al. Regional hyperthermia combined with radiotherapy for uterine cervical cancers: a mulB-‐insBtuBonal prospecBve randomized trial of the internaBonal atomic energy agency. Int J Radiat Oncol Biol Phys. 2005;61:145-‐153.

Salazar OM, Sandhu T, da MoRa NW et al. FracBonated half-‐body irradiaBon (HBI) for the rapid palliaBon of widespread, symptomaBc, metastaBc bone disease: a randomized Phase III trial of the InternaBonal Atomic Energy Agency (IAEA). Int J Radiat Oncol Biol Phys. 2001;50:765-‐775.

Dobrowsky W, Huigol NG, JayaBlake RS et al. AK-‐2123 (Sanazol) as a radiaBon sensiBzer in the treatment of stage III cervical cancer: results of an IAEA mulBcentre randomised trial. Radiother Oncol. 2007;82:24-‐29.

CONCLUSION

TECHNICAL COOPERATION

HUMAN HEALTH DIVISION

The Coordinated Research Activities are complementary to the Agency’s Technical Cooperation Projects (TCPs), with the knowledge gained via coordinated research used to enhance the quality of Technical Cooperation Projects.

CONCLUSIONS

• Coordinated research activities permit the acquisition and dissemination of new

knowledge and technologies, as well as the adaptation to the needs of the MS

• Knowledge generated by CRAs can improve the quality of TC projects

• Coordinated research activities contribute to capacity building in clinical research

• Evidence generated from CRPs can support adapted recommendation

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