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CHRONIC

MYELOBLASTICLEUKEMIA

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1. Epidemiology andEtiology

Epidemiology

- 1!"#$ o% le&'emia and ()*oni(le&'emia i+ mo+t o%ten %o&nd inIndone+ia.

- T)e in(iden(e in ,e+te*n (o&nt*ie+- 1to 1. / 1##.###/yea*+

- O%ten a0o&t middle age ,it) a pea'age o% #!# yea*+.

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Etiology- Radiation

- Le&'emogeni'- ()emi(al+ ae(t t)e

%*e2&en(y o% le&'emia. S&() a+-Ben3ene

- He*edita*y- do,n +ynd*ome

-

4i*&+ in%e(tion- *et*o5i*&+6 HTL4!1

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". 7at)ogene+i+

BCR!ABL gene on t)e 7)iladelp)ia()*omo+ome 87)9 (a&+e+ e:(e++i5ep*oli%e*ation o% pl&*ipotent +tem (ell+

in )ematopoie+i+ +y+tem.

La+t a long time d&e to t)e age o%(ell le&'emia BCR!ABL gene a*e anti!

apoptoti(. So &*gent )ematopoie+i+ +y+tem d&e

to t)e %o*mation o% a0no*mal (lone+

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;. Clini(al Mani%e+tation+

CHRONIC 7HASE

- A+ymptomati(

-

Hipe*'ata0oli' +ymptom+- ,eig)tlo++6 ,ea'ne++6 ano*e:ia6 and nig)t+,eat+.

- Spelomegali

- Symptom+ o% go&t6 impai*ed 5i+ion

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ACCELERATE< 7HASE

- =e5e*6 %atig&e6 0one pain 8+te*n&m9 i+getting p*og*e++i5ely

- Le&'o(yto+i+

- 7latelet+ de(*ea+ed

-

7*omielo+it> ;#$

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. Ba+i(