ChemInform Abstract: Synthesis and Antiviral Activities of Fluorinated Acyclic Nucleoside...
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1999 nucleic acids nucleic acids U 0700 17 - 242 Synthesis and Antiviral Activities of Fluorinated Acyclic Nucleoside Phosphonates. — In order to find novel antiviral agents with improved activity and selectivity, title compounds such as (VII), (IX), and (X) are synthesized. The base used in the electrophilic fluorination step is critical for the yield. The most interesting compound (X) is active against human cytomegalovirus, Epstein–Barr virus and measles with EC 50 values of 5.6, 1.6, and 32 μg/mL, respectively. — (CHEN, WEI; FLAVIN, MICHAEL T.; FILLER, ROBERT; XU, ZE-QI; J. Chem. Soc., Perkin Trans. 1 [old] (1998) 23, 3979-3988; MediChem Res., Inc., Lemont, IL 60439, USA; EN) 1
Transcript of ChemInform Abstract: Synthesis and Antiviral Activities of Fluorinated Acyclic Nucleoside...
1999 nucleic acids
nucleic acidsU 0700
17 - 242Synthesis and Antiviral Activities of Fluorinated Acyclic NucleosidePhosphonates. — In order to find novel antiviral agents with improvedactivity and selectivity, title compounds such as (VII), (IX), and (X) aresynthesized. The base used in the electrophilic fluorination step is criticalfor the yield. The most interesting compound (X) is active against humancytomegalovirus, Epstein–Barr virus and measles with EC50 values of 5.6,1.6, and 32 µg/mL, respectively. — (CHEN, WEI; FLAVIN, MICHAEL T.;FILLER, ROBERT; XU, ZE-QI; J. Chem. Soc., Perkin Trans. 1 [old] (1998)23, 3979-3988; MediChem Res., Inc., Lemont, IL 60439, USA; EN)
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