Chapters 8 & 18: Metabolism and Movement of Lipids
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Chapters 8 & 18: Metabolism and Movement of Lipids What types of fats are needed for cell function? Where are each of these types of fats manufactured? How do phospholipids in the outer leaflet of the plasma membrane get there? How do lipids move from place to place in the cell? Where is cholesterol made? What are lipoproteins? How is lipid metabolism regulated? How does imbalance in lipid metabolism
description
Chapters 8 & 18: Metabolism and Movement of Lipids. What types of fats are needed for cell function? Where are each of these types of fats manufactured? How do phospholipids in the outer leaflet of the plasma membrane get there? How do lipids move from place to place in the cell? - PowerPoint PPT Presentation
Transcript of Chapters 8 & 18: Metabolism and Movement of Lipids
Chapters 8 & 18:Metabolism and Movement of Lipids
What types of fats are needed for cell function?
Where are each of these types of fats manufactured?
How do phospholipids in the outer leaflet of the plasma membrane get there?
How do lipids move from place to place in the cell?
Where is cholesterol made?
What are lipoproteins?
How is lipid metabolism regulated?
How does imbalance in lipid metabolism contribute to atherosclerosis, heart attacks, and strokes?
What types of fats are needed for cell function?
Fatty Acid Synthesis and Transport
Acetyl coA carboxylase
Acetyl CoA carboxylase catalyzes the reaction:
acetyl CoA + HCO3- + ATP -> malonyl CoA + ADP + Pi
Six molecules of malonyl CoA and one molecule of acetyl CoA then interact sequentially with fatty acid synthase to yield the final product, palmitate.
Gene Name Common Name Other Names(species)
Expression
FABP1 Liver L-FABPh-FABPZ protein
liver, intestine, kidney, lung(est)
FABP2 Intestinal I-FABP gFABP
intestine
FABP3 Heart/Muscle H-FABPM-FABPMDGIc-FABP
heart, mammary, skeletal muscle
FABP4 Adipocyte ALBPaP2A-FABPp422p15
adipose, macrophage
FABP5 Epidermal KLBP (murine)mal-1 (murine)E-FABP (human)PA-FABP (human)C-FABP (rat)S-FABP (rat)LE-LBP (rat)DA11 (rat)LP2 (bovine)Melanogenic Inhibitor
abnormal skin, lens, adipose, endothelial cells, lung, mammary,brain, stomach, tongue, stomach,placenta, heart, skeletal muscle, intestine, testis, retina
FABP6 Ileal IlLBPILBPBABPIL-FABPI15PGastrotropin
ileum
Gene Name Common Name Other Names(species)
Expression
FABP7 Brain B-FABPBLBPMRGR-FABP (chicken)
brain, olfactory bulb
FABP(9) Testis T-FABPTLBPPERF15
testis
MP2 Myelin P2 Myelin P2PMP2MLBPMy-FABP
Schwann cells
cytosol
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