CENTRE FOR ADVANCED IMAGING

CENTRE FOR ADVANCED IMAGING 2012 ANNUAL REPORT

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CENTRE FOR ADVANCED IMAGING | 2

About the Centre for Advanced Imaging The Centre for Advanced Imaging (CAI) is a strategic initiative of The University of Queensland. It reflects the growth in biotechnology and biomedical research requiring spectroscopic and imaging research capabilities.

Multimodality

The CAI is an integrated research facility harnessing the spatial resolution of ultra-high-field Magnetic Resonance Imaging (MRI), and the sensitivity of Positron Emission Tomography (PET) in detecting molecular targets and the structural and functional characterisation of molecules using high-resolution Nuclear Magnetic Resonance (NMR) and Electron Paramagnetic Resonance (EPR) spectroscopy.

Multidisciplinarity

CAI researchers work on innovations in spectroscopic and imaging technology, imaging biomarker development and in biomedical research disciplines, frequently in collaboration with clinical research sites such as the Royal Brisbane and Women’s Hospital (RBWH), Princess Alexandra Hospital (PAH) and the Wesley Hospital.

The broad areas of research performed at CAI include

• Imaging Technology Development and Engineering • Molecular Imaging • Biomedical Imaging • Material Science and Imaging • Data processing and Computational Analysis • Structural Biology and Chemistry

CAI Mission Statement

CAI undertakes collaborative research and education in imaging and imaging-related disciplines at UQ engaging in the development of leading edge technology and methodology and its application to important questions that span the spectrum from fundamental to applied and clinical research.

2012 Annual Report


CONTENTS

About the Centre for Advanced Imaging 2

2012 Directors Report 4

Organisational Structure 5

CAI Advisory Board 5

Structure and Staff 6

CAI Management Committees 7

CAI Staff 9

Research at CAI 10

Prof David Reutens - Director 10

Prof Ian Brereton – Director of Research and Technology 11

Prof Graham Galloway – Biomedical Imaging and Spectroscopy 14

Prof Graeme Hanson – EPR Spectroscopy and Imaging 15

Prof Andrew Whittaker – Polymer Group 17

2012 Research Grants 20

Research Higher Degree Students 25

Honours Students 27

CAI Education Programs 28

Postgraduate Coursework 28

Short Courses 29

Undergraduate Scholarships 29

Outreach education 29

External Engagement 30

National Imaging Facility 30

Queensland NMR Network 32

CAI Operations 33

Construction of the new CAI building 33

Facilities 33

Occupational Health and Safety 38

Professional Presentations and Awards 39

Editorial Board Participation 39

Conference Presentations 40

Awards 42

Publications 43

2012 Annual Report


2012 Directors Report

T.S. Eliot considered Lord Tennyson’s ‘Ulysses’ a perfect poem. The poem begins with the protagonist reflecting on the challenges and successes of the long and eventful journey back to Ithaca. The CAI’s journey has been relatively short, but no less eventful! In just three years since its establishment, CAI has made tremendous progress. In September 2012, we moved into the completed first stage of the new $55M CAI building and started to commission its state-of-the-art equipment. The second stage of construction will be completed in 2013. The success of this project is testament to the expertise and efforts of many CAI staff who have worked tirelessly during planning and construction. A special mention must go to Deputy Director of Operations, Rebecca Osborne, and to Alan Pringle, Don Maillet and Antony King from CAI’s Engineering and Infrastructure team for their hawk-eyed vigilance. The new CAI building is a strategic initiative of the University and has received co-funding from the Commonwealth Education Investment Fund, the Queensland Government and ANSTO.

As part of our portfolio of landmark imaging instruments, we took delivery of the world’s first commercial small animal MRI-PET scanner, complementing our other molecular imaging instruments and our facilities for producing PET imaging probes. This instrument adds a new dimension to our capabilities for studying the living organism which already include the most powerful small animal MRI scanner in the Southern hemisphere. With these instruments, CAI researchers have been creating the next generation of mouse brain atlases in collaboration with pioneering Australian anatomists and brain cartographers, George Paxinos and Charles Watson. UQ’s track record in imaging technology development was highlighted in 2012 by the awarding of the Australian Academy of Technological Sciences (ATSE) Clunies Ross Award to CAI’s Executive Committee member Prof Stuart Crozier for his contributions to the field of Magnetic Resonance Imaging over 20 years.

Having been honoured by cities, councils and governments, Ulysses is restless for new adventure. So too, CAI now faces the challenge of best harnessing its powerful imaging

armamentarium to create new knowledge. CAI is a partner in the ARC Centre for the Science of Learning which brings together researchers from eight universities and nine partner organisations to help translate our understanding of the learning process into more effective teaching practices. This new endeavour adds to CAI’s national leadership in existing initiatives such as the National Imaging Facility, of which CAI’s Prof Graham Galloway is Director of Operations. Our success in gaining competitive grant funding from the ARC and NHMRC continued in 2012. A particular highlight is the next generation of researchers joining the Centre. Jeffrey Harmer’s ARC Future Fellowship sees him relocate to CAI from Oxford University, joining CAI’s three other Future Fellows, Mehdi Mobli, Kris Thurecht and Idriss Blakey. Hana Burianova, from Macquarie University joins us on an ARC Discovery Early Career Researcher Award, Marcus Gray from Monash University on an NHMRC Early Career Fellowship and Simone Bosshard from ETH Zurich on a UQ Fellowship. We look forward to their contribution to our intellectual life.

Education and training are an important part of CAI’s mission. Enrolments in the Centre’s postgraduate courses in Magnetic Resonance Technology continue to grow, allowing our experts to transmit their knowledge to radiographers, biomedical engineers and other health professionals working with MRI equipment. Development of the new Master of Molecular Imaging continues apace in collaboration with the University of Sydney with the aim of forming international leaders in molecular imaging.

Baseball’s ‘wise fool’ Yogi Berra (after whom an eponymous learning centre is named) was right. Tremendous changes are afoot in tertiary education. With the rest of the sector globally, CAI is readying for the revolution in delivery of education using

online technologies. The New York Times dubbed 2012 the year of the MOOC – Massive Open Online Course – which promises unlimited access to course material via the internet. At the end of 2012, CAI remains, as Tennyson wrote

‘… strong in will To strive, to seek, to find and not to yield.’

‘To follow knowledge like a sinking star, Beyond the utmost bound of human thought’

‘It's tough to make predictions, especially about the future.’

2012 Annual Report


Organisational Structure

CAI Advisory Board

The Centre for Advanced Imaging Advisory Board was formed to advise the Centre on: 1. Best practice in operation and management of the imaging research facility; 2. CAI’s research and research training activities to support and improve UQ research outcomes; 3. CAI’s annual budget and funding 4. Strategic institutional, local, national and international linkages; 5. Strategic issues and initiatives at UQ impacting on CAI

The Board Membership includes:

Prof Max Lu, Deputy Vice Chancellor, Research, UQ Prof Perry Bartlett, Director, Queensland Brain Institute, UQ Prof Nicholas Fisk, Executive Dean, Faculty of Health Sciences, UQ Prof Graham Schaffer, Executive Dean, Faculty of Engineering, Architecture and Information Technology, UQ Dr Marie-Claude Gregoire, Head Functional Imaging Group, ANSTO

2012 Annual Report


Structure and Staff

The Centre for Advanced Imaging employs more than 57 staff, in research, facilities and administration. Staff include medical practitioners, neuropsychologists, radiographers, engineers, scientists and administrative staff.

CAI continues to strengthen its research links with other UQ units, specifically with joint appoints (AIBN and QBI) and through the co-supervision of over 50 postgraduate students working in a diverse range of disciplines, such as Medicine, Computer Science, and the Biological and Chemical Sciences.

DVCR

Prof. Max Lu

Director

Prof. David Reutens

Director, Research and Technology

Prof. Ian Bereton

Research Group

Group Leader

Prof. Graham Galloway

Research Group

National Imaging Facility

Group Leader

Prof. Graeme Hanson

Research Group

Group Leader

Prof. Andrew Whittaker

Research Group (joint with AIBN)

Deputy Director, Operations

Rebecca Osborne

Operations and Administration

Reutens Research Group

2012 Annual Report


CAI Management Committees

The CAI Executive is assisted in the management of specific activities and facilities by the following committees.

Committee Committee Members Schedule

Executive

David Reutens (Chair) Graham Galloway Ian Brereton Andrew Whittaker

Graeme Hanson Rebecca Osborne Stuart Crozier Lesley Green (Secretary)

Monthly

Budget David Reutens Ian Brereton Rebecca Osborne (Chair)

Nancy Eluigwe Charles Topp Sheree Manning (Secretary)

Monthly

Imaging - Scientific

Ross Cunnington (Chair) - QBI David Reutens Graham Galloway Ian Brereton Greig de Zubicaray Julia Hocking

Aiman Al Najjar Michael Breakspear Katie McMahon Stuart Crozier Paul Dux Sandrine Kingston-Ducrot (Secretary)

Monthly

Education

Gail Durbridge (Chair) Graham Galloway (RHD) Idriss Blakey Kristofer Thurecht Viktor Vegh

Gary Cowin Qurain Alshammari (Student Rep) David Reutens Ian Brereton Rebecca Osborne Sandrine Kingston-Ducrot (Secretary)

Monthly

IT Working Group

David Butler (Chair) Rebecca Osborne

Andrew Janke David Reutens

Quarterly

Research

Graeme Hanson (Chair) Ian Brereton Andrew Whittaker Firas Rasoul Gary Cowin Greg Pierens

Viktor Vegh Nyoman Kurniawan Andrew Janke Yasvir Tesiram David Reutens Sandrine Kingston-Ducrot (Secretary)

Monthly

Imaging -Operations

Graham Galloway (Chair) Ross Cunnington Aiman Al Najjar Anita Burns Katie McMahon Alan Pringle

Don Maillet Rebecca Osborne David Reutens Ian Brereton Bridget Waugh (Secretary)

Monthly

Instrument Operations

Ian Brereton (Chair) Rebecca Osborne Nyoman Kurniawan Greg Pierens Lynette Lambert Ekaterina Strounina

Chris Noble Karine Mardon Don Maillet Alan Pringle Graeme Hanson Gary Cowin Bridget Waugh (Secretary)

Monthly

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OHS

Simon Nevin (Chair) Ian Brereton Karine Mardon Gail Durbridge Vic Leach

Wael Ghafor David Butler Anita Burns Alan Pringle Lesley Green (Secretary)

Monthly

RHD Sub-Committee

Julia Hocking (Chair) David Reutens Graham Galloway

Kristofer Thurecht Viktor Vegh Mehdi Mobli Katie McMahon Sandrine Kingston-Ducrot (Secretary)

Monthly

Small Animal MRI Scientific Committee

Linda Richards (Chair) - QBI David Reutens Nyoman Kurniawan Graham Galloway

Marc Ruitenberg - SBS Lizzie Coulson - QBI Ilse Buitens (Secretary) - QBI

Monthly

7T Steering Committee

Stuart Crozier (Chair)- ITEE David Reutens Graham Galloway

Graeme Hanson Ian Brereton Rebecca Osborne Lesley Green (Secretary)

Monthly

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CAI Staff

Director Professorial Research Fellow

Prof David Reutens Prof Graham Galloway

Director Research and Technology Prof Graeme Hanson

Prof Ian Brereton Prof Andrew Whittaker

Deputy Director, Operations Associate Professor

Mrs Rebecca Osborne Assoc Prof Idriss Blakey Administrative Officers Senior Research Fellows Mrs Lesley Green Dr Gary Cowin Ms Bridget Waugh Dr Andrew Janke Student Administrative Officer Dr Katie McMahon Mrs Sandrine Kingston-Ducrot Dr Aaron Micallef Human Resources Officer Dr Mohammadmehdi Mobli Ms Sheree Manning Dr Firas Rasoul Finance Managers Dr Zuyao Shan Mrs Nancy Eluigwe Dr Quang Tieng Mr Charles Topp Dr Kristofer Thurecht Information Technology Manager Lecturer Mr David Butler Mrs Gail Durbridge Software Developers Research Fellows Mr Meng-Kuan (Adam) Lin Dr Marianne Keller Mr Oliver Nicolini Dr Randal Moldrich Mr Harald Waxenegger Dr Horst Schirra Operations Manager Dr Yasvir Tesiram Mr Alan Pringle Dr Viktor Vegh Engineers Postdoctoral Research Fellows Mr Antony King Dr Simone Bosshard Mr Donald Maillet Dr Julia Hocking Occupational Health & Safety Manager Dr Irina Kharatishvili Dr Simon Nevin Dr Caroline Mas Radiographer Dr Ekaterina Strounina Mrs Anita Burns Dr Jeremy Ullmann Facility Managers Dr Michael Vogel Mr Aiman Al Najjar Research Assistant Ms Lynette Lambert Ms Ilvana Dzavic Dr Karine Mardon Miss Gayeshika Leanage Dr Michelle McCleary Mr David She Dr Nyoman Kurniawan Miss Rebecca Williams Dr Chris Noble National Imaging Facility Administration Dr Greg Pierens Dr Annie Chen Mr Damion Stimson Dr Michelle McCleary

2012 Annual Report


Research at CAI Research utilising CAI facilities is performed to better understand brain function and development; to study neurological disorders such as dementia, epilepsy, stroke, multiple sclerosis, Parkinson’s Disease and motor neurone disease; cancers, including those affecting the brain, breast, liver and pancreas; to evaluate the healthy musculoskeletal system and disorders of bones, joints, muscles and other soft tissues. Many of these studies involve the development of new imaging agents and biomarkers to detect disease earlier and to monitor its response to treatment. Our facilities are used to increase understanding of how biologically important molecules such as proteins, enzymes and receptors behave and interact allowing us to design targeted imaging agents in combination with therapeutic delivery systems (theranostics). CAI facilities are utilised for research programs in basic science through preclinical to biomedical imaging that form a translational imaging pipeline from the benchtop to the bedside.

Prof David Reutens - Director

The Reutens group uses combination of imaging techniques such as MRI, EEG, transcranial magnetic stimulation and PET to study functions such as memory in the healthy brain, the mechanisms behind diseases such as epilepsy and stroke and how the brain responds to overcome injury. Some of the research studies involve patients with injuries or genetic mutations that affect brain function – these studies are able to provide privileged insights into how the brain works. With his collaborators, he uses imaging to study animal models of disease. Group members are working on ways of improving imaging technology such as the development of new diagnostic agents and new mapping methods that may improve the safety of brain surgery.

The Reutens group continued to build on its work in three key areas:

• Anatomical imaging methodology and brain atlas creation: Release of the mouse brain atlas is progressing, with the project likely to be completed in 2013. Our efforts have stimulated international interest in using the minimum deformation template and the atlas segmentation. Work is also progressing on imaging of barrel cortex and on creation of the zebrafish brain atlas. Group members are also working on new methodologies for diffusion and susceptibility-weighted imaging. Development of biomarkers of epileptogenesis: A range of imaging and molecular biomarkers of epileptogenesis are being explored in different animal epilepsy models.

• New methods for functional brain imaging are being explored including diffusion fMRI and neural current imaging. As part of the latter, group members have also been working on ultra low field MRI.

Prof. David Reutens

2012 Annual Report


Prof Ian Brereton – Director of Research and Technology

Imaging and Spectroscopic Biomarker Development

Research activities in the Brereton group are linked by a common aim of developing methods for the improved understanding of the molecular basis of biological function and disease, and informing the development of new diagnostic imaging technologies and approaches to therapy. The research is primarily based upon Magnetic Resonance Spectroscopy and Imaging methods and is applied to a breadth of scale, from the molecular structure and function of important biomolecules and metabolic profiling of living systems to targeted imaging agents and biomarkers for detection of disease and disorders.

• With the high sensitivity, reliability and accuracy of modern instrumentation, magnetic resonance spectroscopy (MRS) has begun to realise some of its potential as a valuable diagnostic tool. The group aims to develop MR technologies for the acquisition of spectroscopic data localised within the body to investigate biochemical pathways and metabolism. These include multidimensional 1H and 13C correlation spectroscopy enhanced with rapid sampling methods, and the application of novel adiabatic pulse design for MRS and MRI, both targeting investigation of fatty acid metabolism in liver and pancreatic cancer. This program is being led by Dr Yasvir Tesiram, a highly experienced spectroscopist who joined the group in 2012 after 10 years at the Oklahoma Medical Research Foundation. Dr Tesiram also initiated a collaboration with a group at the Max Planck Institute Florida for the construction of a high resolution MRI atlas of the tree shrew brain.

• Metabolic profiling of biological systems by NMR is also an emerging field that holds promise for medical diagnosis and systems biology research. A program in biomedical applications of NMR metabolomics is being led by Dr Horst Schirra who will establish the technology at CAI utilising a new 700 NMR system with high throughput sample handling expected in 2013. A highlight of Dr Schirra's research in 2012 was publication in Science of his work on genetic mutations of the enzyme DLDH shown to be responsible for phosphene resistance in the nematode. This work has important implications for the agrichemical industry and will form the basis of a broader systems biology program investigating the role of DLDH in metabolic regulation.

• Dr Mehdi Mobli was awarded an ARC Future Fellowship in 2012 and joins CAI to further his research in biomolecular NMR methods development in addition to an extensive program in structure and function of venom-based peptides and sodium channel membrane proteins. Dr Mobli has established a strong international reputation for his work in rapid data acquisition methods in multidimensional NMR spectroscopy and will establish a major program in structural biology at CAI. Contributing to this effort, Dr Caroline Mas, has utilised biomolecular NMR spectroscopy to help understand the molecular details of cellular trafficking in particular PX domain - phosphoinositide interactions. This follows her work on molecular interactions that regulate death receptor-mediated apoptosis, involving the binding of the FADD protein adaptor in complex with a viral inhibitor.

• 2012 saw the completion of a major Queensland State Government NIRAP project funded to develop imaging biomarkers for early detection of Alzheimer's disease. The group's contribution to this project, led by Dr Marianne Keller, was to perform structural and diffusion-based MRI on a mouse model of AD, and to develop 19F imaging methods for detection of fluorinated hyperbranched polymeric imaging agents functionalised to bind to Amyloid-beta plaque.

• Diffusion-based imaging is an established MRI technique finding new applications, especially in neuroimaging. Dr Nyoman Kurniawan has established a research program in the development of DTI and DWI methods for examining brain structure and function in animal models of neurodegeneration. A PhD project (Othman Al Omair) is examining diffusion tensor parameters derived from brain structures as a function of disease progression in a mouse model of multiple sclerosis. Dr Kurniawan has also developed a novel

Prof. Ian Brereton

2012 Annual Report


multimodal simultaneous MRI-fluorescence imaging platform for unravelling the physical basis of fMRI signal. Other projects included diffusion MRI of spinal cord injury and MRI studies of foetal alcohol spectrum disorder.

• Understanding the physiological origin of macroscopic MR signal from complex living systems characterised at the microscopic histological level would enormously enhance the power of MR imaging and in vivo spectroscopy to solve intractable biological problems. Knowledge of the contributions of various structural and physiological information garnered from histological and other imaging modalities at the cellular level to the MR signal obtained on a ten-fold or larger scale would allow a more accurate and detailed analysis of in vivo MR data. A CAI collaborative project being led by Dr Andrew Janke aims to develop these correlations.

• Small molecule NMR plays a key role in the identification and structural characterisation of naturally occurring biologically active compounds as well as synthetic molecules designed as potential drug candidates or targeted imaging probes. Drs Lynette Lambert and Greg Pierens undertook collaborative research projects involving identification of novel compounds isolated from various marine species and saponins from terrestrial plants. Structural analysis was carried out for a series of Schiff bases designed as potential PET imaging agents in Alzheimer’s disease.

• Solid state NMR spectroscopy allows the study of chemical and physical structure in the solid form. Dr Katia Strounina contributed expertise in solids NMR to a range of research projects including the study of cellulose and starch composition of cell wall in grains, functionalised silica derivatives being developed for drug delivery and biocompatible materials.

• PET and CT imaging are new technologies to CAI and while 2012 saw the 6 month hibernation of the preclinical PET/CT instrument while awaiting completion of its new lab, Dr Karine Mardon maintained research activities in a number of projects utilising the microCT. These included the study of trabecular bone in a model of osteoporosis, analysis of pore structure and fluid saturation in coal, bone formation induced by inflammation in a model of ankylosing spondylitis, measurement of crania-facial changes in a mouse model of Down syndrome and high resolution imaging of coral to determine the relationship between growth rates and temperature.

• MRI is an invaluable tool for diagnosis of musculoskeletal disease and disorders. In collaboration with Gail Durbridge and Wesley Hospital orthopaedic surgeon, Mark Richardson, a MRI study of knee structure of patients with chronic patella dislocation, pre and post intervention, was initiated with funding from the Wesley Research Institute. The results of this work will provide a better understanding of risk factors for patella instability, allow better interventional planning and therefore improve patient outcomes.

2012 Annual Report


Research Highlight

CAI RESEARCHERS HELP MITIGATE INSECT PEST DESTRUCTION OF GRAINS, DR HORST SCHIRRA

Dr Horst Schirra and his collaborators have made a discovery that will allow farmers and grain handlers to more effectively manage the problem of grain pest resistance to fumigants. The research was published in the prestigious journal, Science, in November.

Eighty percent of grain is treated with phosphine, a toxic chemical that is used to fumigate stored grain and kill insect pests. Phosphine is classified as being “residue-free” and so the treated grain is safe for human consumption. Unfortunately, high levels of phosphine resistance have been identified in several species of stored grain pests in Australia.

The research team identified a gene encoding a core metabolic enzyme, dihydrolipoamide dehydrogenase (DLD) that, when mutated, was responsible for phosphine resistance in a range of insect pests.

Dr Schirra’s contribution to the work was to measure how insects, that were either sensitive or resistant to phosphine, responded to phosphine in terms of metabolite production. This analysis helped tease out the mechanism by which DLD mutation might confer phosphine resistance.

The research could enable problem insects to be detected before an outbreak occurs, enabling the effective functional life of phosphine to be extended. It also enabled the researchers to identify a new class of compound that might be used in conjunction with phosphine to control grain insects.

Dr Schirra said the study helped shed light on how resistance affects the metabolism of roundworms and insects. Dr Schirra explains the impact as follows: “This allows us to better understand how resistance develops and will provide insights into possibilities for new fumigants, or treatments that may block the resistance”.

The research involved scientists at DAFF Queensland, the University of Queensland School of Biological Sciences, the CRC for National Plant Biosecurity, the Queensland Brain Institute (QBI) and the University of Queensland Centre for Advanced Imaging.

Funding was received from the Queensland State Government to support the QNN 900MHz, high-resolution nuclear magnetic resonance facility at the Centre for Advanced Imaging. The Australian Research Council, Grains Research and Development Corporation, National Institutes of Health and the National Health and Medical Research Council also supported the research.

Dr Horst Schirra

Red flour beetle (Tribolium castaneum)

2012 Annual Report


Prof Graham Galloway – Biomedical Imaging and Spectroscopy

The Biomedical Imaging and Spectroscopy Research Group is built around driving new applications of Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy. One of the major strengths of CAI is the breadth of instrumentation, and the opportunity that this provides for developing projects on a range of scales. Of particular note is the use of micro-imaging of biopsy samples to inform the interpretation of data from in-vivo clinical imaging, as has been demonstrated with prostate cancer. During 2012 the pre-clinical MRI-PET was installed, marking an exciting new direction for the group, as we embrace Molecular imaging, to complement the structural and functional imaging that has been the focus of the group’s research.

Other key developments during 2012 covered areas as diverse as understanding language and deficits following stroke, understanding genetic versus environmental factors in brain development, assessing liver damage as a

consequence of metabolic disease and obesity, understanding changes in muscle function following a whiplash injury and assessing cardiac fibrosis in patients with hypertension. All these contribute to the national research priority of Healthy Ageing, and as such have the potential to make a difference in the lives of individuals, as well as helping to diminish the burden of disease in society.

A highlight for any academic researcher is the graduation of students who they have mentored. In 2012 three students from our group achieved this milestone. Dr Gabriella Blockland PhD is furthering her career at Harvard University, Dr Shiree Heath PhD, who was awarded the Dean’s Award for Research Higher Degree Excellence, has moved to Macquarie University. A special mention goes to Abdalrahman Al-Salihi, MPhil, who faced the challenges of having to leave his family in Iraq while he was studying. Abd has returned to Iraq to lecture Physics at Basrah University.

Prof. Graham Galloway

2012 Annual Report


Prof Graeme Hanson – EPR Spectroscopy and Imaging

EPR Spectroscopy and Imaging

Highlights for the EPR group include the award of an ARC Future Fellowship to Dr. Jeffrey Harmer which included a high power Q-band upgrade of the pulsed EPR spectrometer, an ARC LIEF grant for a digital upgrade of the pulsed EPR spectrometer including a DICE II ENDOR unit (1-400 MHz), a successful bid to jointly host (CoChairs: Prof. Sue Berners-Price and Prof. Graeme Hanson) the 7th Asian Biological Inorganic Chemistry conference on the Gold Coast in November-December 2014 and the award of a high Honours Class 2A to Joshua Harbort for the development of Dynamic Nuclear Polarisation, whom achieved a 160 fold enhancement of proton NMR signals. Additional high impact research results are briefly described below.

EPR Research Highlights

CO2 fixation – A biological function for marine cyclic peptides?

A multidisciplinary international collaboration involving researchers at the University of Heidelberg and the University of Queensland have unravelled the geometric and electronic factors governing CO2 fixation by dinuclear CuII complexes of the naturally occurring marine cyclic pseudo-octapeptides ascidiacyclaimde (H4asc) and patellamideD (H4patD). The study involved the synthesis and spectroscopic (EPR), characterisation of two synthetic derivatives of these cyclic pseudo-octapeptides as well as their CuII complexes (Comba, P.; Dovalil, N.; Gahan, L.R.; Haberhauer, G.; Hanson, G.R.; Noble, C.J.; Seibold, B.; Vadivelu, P. Chem. Eur. J., 2012, 18, 2578-2590). The two cyclic peptide derivatives differ from the naturally occurring octapeptides by variation of the incorporated heterocyclic donor groups and the configuration

of the amino acids connecting the heterocycles, producing more rigid macrocycles with significant differences in folding of the cyclic peptide. These structural variations allowed a detailed spectroscopic and quantum chemistry study of the geometric and electronic factors responsible for the formation of di-nuclear CuII complexes and the reactivity of the complexes towards CO2 fixation. The results provided structure-reactivity correlations, and suggest why Nature may have chosen oxazolines and thiazoles as the incorporated heterocycles.

Formation of World’s first Tetraazetidine (4-Membered Nitrogen Ring)

Researchers at Griffith University (David Camp, Marc Campitelli and Ian Jenkins) and the University of Queensland (Graeme Hanson) have synthesised and characterised a tetrazetidinetetracarboxylate radical cation, containing the elusive cyclic N4 ring system. The radical is formed from diisopropylazodicarboxylate (DIAD) and triphenylphosphine (as catalyst) at 0-25 °C (J. Am. Chem. Soc., 2012, 134, 16188-16196). Electron paramagnetic resonance (EPR) spectroscopy revealed a 9-line spectrum, with hyperfine coupling constants indicative of four almost magnetically equivalent nitrogen atoms. The radical species was surprisingly long-lived, and could still be observed several hours after generation and standing at 25 °C. The structure was confirmed by DFT calculations. The lowest energy conformation of the N4 ring was slightly puckered, with the alkyl carboxylate groups all trans and the four carbonyl

Prof. Graeme Hanson

2012 Annual Report


groups aligned in a pinwheel arrangement around the ring. The reason for the magnetic inequivalence of the nitrogens is presented as a JACS Image Challenge. Analogous results were obtained with the original Mitsunobu reagents, Ph3P and diethyl azodicarboxylate (DEAD), but not with Ph3P and di-tert-butyl azodicarboxylate. A mechanism is proposed based on a radical version of the Rauhut-Currier or Morita-Baylis-Hillman reactions.

Role of semiconductivity and ion transport in the electrical conduction of melanin

Melanins are pigmentary macromolecules found throughout the biosphere that, in the 1970s, were discovered to conduct electricity and display bistable switching. Since then, it has been widely believed that melanins were naturally occurring amorphous organic semiconductors. An international multidisciplinary research team involving Dr. Mostert, Assoc. Prof. Powell, Prof. Hanson, Prof. Gentle and Prof. Meredith (The University of Queensland), Dr. Pratt (ISIS Facility, Rutherford Appleton Laboratory, UK) and Prof. Sarna (Jagiellonian University, Poland), have utilised electrical photo-conductivity, muon spin relaxation, and photo-EPR measurements of solid state melanin as a function of environmental humidity to show that hydration of melanin shifts the comproportionation equilibrium (below) so as to dope electrons (semiquinone) and protons into the system (Mostert, A.B.;Powell, B.J. Pratt, F.L.; Hanson, G.R.; Sarna, T.; Gentle, I.R.; Meredith, P. Proc. Natl. Acad. Sci. USA, 2012, 109, 8943-8947). The equilibrium explains why melanin at neutral pH only conducts when “wet” and suggests that both carriers play a role in the conductivity. Understanding melanin as an electronic-ionic hybrid conductor rather than an amorphous organic semiconductor opens exciting possibilities for bioelectronic applications such as ion-to-electron transduction given its biocompatibility.

2012 Annual Report


Prof Andrew Whittaker – Polymer Group

Professor Whittaker is a joint appointment with the Australian Institute for Bioengineering and Nanotechnology, UQ

The Polymer Group works broadly in three fields, namely 1) biomaterials science, 2) polymers for lithography and 3) imaging science and technology. The group is led by a team of experienced scientists (Andrew Whittaker, Group Leader; Idriss Blakey; Kris Thurecht; Firas Rasoul; Hui Peng) and currently consists of approx. 45 scientists.

Biomaterials science: The Queensland Government NIRAP Project on Spinal Cord Regeneration aims to develop materials capable of encouraging regeneration of nerve cells in the damaged spinal cord. To achieve this, the team lead by Dr Rasoul has prepared a library of readily-functionalised polyurethanes which can be electrospun into porous scaffolds for cell regeneration. In other work we have developed methods for production of highly regular polymeric networks for verification of models of diffusion, and ultimately for drug delivery. Finally we are working with Prof Maree Smith of TetraQ and Eli Lilly on developing degradable

polymers for delivery of pain drugs to the intra-thecal space; the target is the relief of chronic pain.

Lithography: Andrew Whittaker and Idriss Blakey were awarded an ARC Linkage grant to collaborate with the Dow Chemical Company to develop new materials for lithography. These include a new concept in the use of block copolymers for healing of lithographic features and therefore printing of integrated circuits at the 22 nm node and below. This technology was protected by the filing of a provisional patent. The team will be collaborating with Dow over the next 3 years on several related projects.

Imaging science and technology: A major research theme of the group is development of novel molecules for imaging of disease. The work is supported by major funding from the Australian Research Council (Fellowships to Whittaker, Blakey and Thurecht) and the National Health and Medical Research Council (to Whittaker and Thurecht and collaborators at QIMR and QUT). The major theme of the research is the detection of early stages of disease with new imaging molecules, capable of both MRI and fluorescence imaging. As the radiochemistry laboratories are established at CAI new PET agents will be developed. These molecules are being designed to both target a particular tissue type and to respond to physiological cues, such as change in local temperature or pH which may indicate a diseased state. Some aspects of this work are protected by the filing of a provisional patent. Kris Thurecht is further developing these molecules for simultaneous imaging and delivery of therapeutic payloads.

Prof. Andrew Whittaker

2012 Annual Report


Research Highlight

SELF ASSEMBLY OF MATERIALS AND NANOFABRICATION: FROM IMAGING AGENTS TO COMPUTER CHIP MANUFACTURE, DR IDRISS BLAKEY

Materials underpin almost all new technologies. The properties and performance of heterogeneous materials and devices are strongly dependent on their morphology in the 5 – 100 nm regime. The main approaches to control the morphology of materials include: 1) top-down approaches such as grinding of materials to make nanoparticles or optical lithography to print devices with nanoscale dimensions; 2) bottom-up approaches such as self-assembly building blocks to give nanoscale assemblies; 3) a combination of top-down and bottom-up approaches. In 2012, our research has contributed to each or these aspects.

Here we would like to highlight two of these approaches that we are investigating. The first uses self-assembly of polymers and gold nanoparticles to generate multimodal constructs for biomedical imaging. Gold nanoparticles have high optical scattering and X-ray cross sections making them attractive for a number of biomedical imaging modalities. In 2012 we have been actively investigating the fundamentals of the processes that dictate the self-assembly of these systems and looking towards controlling factors such as the aggregate size which dictate the optical properties and imaging performance.

The second approach seeks to combine top-down and bottom-up approaches, where we are looking towards generating processes for ultra-high resolution printing processes for manufacture of computer chips and next-generation hard drives. This approach involves using templates prepared by top-down optical

lithography to guide the self-assembly of polymer-based building blocks. Lithographic based printing techniques are advantageous because they are

compatible with high volume manufacture, where it is possible to intimately control the position of printed features, but is limited in the size of the features that they can print. On the other hand self-assembly processes can achieve much smaller feature sizes (<10 nm), but often the positioning of these features can be random. Ultimately, combining these processes this will lead to the ability to precisely control the placement of these small features. We are investigating novel materials that can achieve very small feature sizes, as well as novel methods for improving the quality of nanoscale printed features.

Dr Idriss Blakey

2012 Annual Report


Research Highlight

DEVELOPING POLYMERS FOR IMAGING DRUG DELIVERY AND THERAPY, DR KRISTOFER THURECHT

The complexities of many disease states are leading to a complete revision as to what constitutes a medicine. Central to the development of new medical entities are multi-modal, multi-functional, biocompatible carrier systems that combine diagnosis with therapy. This particular subset of nanomedicine is often termed "theranostics", and aims to develop materials that utilise multimodal imaging to provide information on efficacy of drug delivery devices. In our group, we take a multidisciplinary approach to developing polymeric theranostics for directly imaging drug delivery, or for the development of multi-modal approaches to molecular imaging using polymers. This research combines various aspects of polymer physical chemistry, synthetic polymer chemistry, pharmaceutical and formulation science, biomaterials, molecular imaging and drug delivery.

My main research direction in 2012 was focussed on developing a series of programs around understanding how the physical and chemical properties of macromolecules can be exploited for developing biocompatible delivery vehicles that facilitate diagnosis and treatment of disease, and translating this fundamental understanding into targeted applications. One example of this has involved synthesising materials that utilise multimodal imaging for tracking therapies and diagnosing diseases. Here, the sensitivity of optical imaging (through use of near infrared fluorophores) is combined with the exceptional spatial resolution of MRI (combined 19F MRI and 1H MRI) to detect various tumour cells in animal models. We have a particular interest in melanoma models (collaboration with Prof. P Parsons, QIMR; Dr G Boyle, QIMR), prostate cancer (collaboration with Prof. P Russell, QUT) and glioma (collaboration with Dr S Rose, CSIRO, and Prof. A Boyd, QIMR). In all cases, the therapy and/or imaging agent are connected to a polymeric carrier that is targeted using antibodies, aptamers or small molecule targeting ligands.

Another example has been the development of polymeric delivery vehicles for gene therapy (in collaboration with Prof. Nigel McMillan, QUT and Prof. Cameron Alexander, Nottingham University, UK). These materials provide a carrier for the gene therapeutic, protecting them from serum nucleases and directing the therapy to tissue of interest in the body (in this case, cervical cancer cells). We track the progress of the therapy in vivo using optical imaging on the Bruker Carestream scanner.

Dr Kris Thurecht

2012 Annual Report


2012 Research Grants

Grants CAI researchers worked on in 2012 included:

Granting Body Title Investigators Total Value of Grant

ARC

Discovery Project

How does dopamine modulation new word learning?

Copland, McMahon, Nathan, Silburn

474,000

Discovery Project

MRI Molecular Imaging Agents - from fundamental design to In Vivo Applications

A Whittaker, A/Prof S E Rose, Dr Peng

979,230

Discovery Project Memory and the temporal lobes Julia Hocking 125,000

Discovery Project

Control of language production and its neural substrates

Copland, McMahon, Silburn, Angwin, Crosson

323,000

Future Fellowship

Smart magnetic resonance imaging (MRI) contrast agents: From early detection to assessment of drug delivery mechanisms

Idriss Blakey 705,321

Future Fellowship

ASAP-NMR: A leap forward in structural studies of proteins using NMR spectroscopy

Mehdi Mobli 660,028

Future Fellowship

Traceable theranostics: tools for visualising drugs delivery and therapeutic benefit in vivo

Kris Thurecht 667,627

Linkage Project

Nanostructured dairy powder for improved functionality

Prof Bhesh R Bhandari, Dr Ranjan Sharma, Prof Andrew K Whittaker, Dr Martin V Palmer

443,336

Linkage Project Novel polymeric microparticles for slow-release intrathecal delivery of analgesics

Maree Smith, Andrew Whittaker, Bruce Wyse, Kris Thurecht, Stephen Arneric, Kelly Knopp, Jeffrey Kennedy

300,000

Linkage Project Sino-Australian neurogenetics initiative.

Prof Brown, Prof Xu, Prof Bartlett, Dr Wallace, Prof Visscher, Prof Mowry, Prof Reutens

690,000

Linkage Project

Next Generation High Sensitivity Polymeric EUV Resists

Andrew Whittaker, Idriss Blakey, Peter Trefonas, James Thackeray

360,000

NHMRC

Project Grant Genetics of brain structure and function

Margaret Wright. Greig de Zubicaray, Katie McMahon, Nicholas Martin, Paul Thompson, Francisco Castellanos, Michael Milham, Arthur Toga

560,217

2012 Annual Report


Project Grant Ventilation heterogeneity and airway remodelling in asthma

A/Pr Francis Thien, A/Pr Bruce Thompson, A/Pr Philip Robinson, dr Benjamin Harris, Dr Gary Cowin, A/Pr Greg King, Dr Deming Wang, Dr Marlies Friese, Dr Michael Ditchfield,

504,750

Project Grant COMBIT: Randomised Controlled Trial of Novel Upper Neurorehabilitation for Congenial Hemiplegia

A/Prof Roslyn Boyd, A/Prof Jenny Ziviani, Dr David Abbot, A/Prof Stephen Rose, Prof Richard Macdonell

469,793

Project Grant Epigenetic and neurobehavioural changes in a new mouse model of foetal alcohol spectrum disorders.

Suyinn Chong, Nina Kaminen-Ahola, Graham Galloway, Nyoman Kurniawan, Harrald Oey, Emma Whitelaw

701,732

Project Grant

Nuclear Receptor 4A3 signalling in skeletal muscle

Prof George Muscat, Gary Cowin 459,105

Project Grant

Identifying eQTLs and endophenotyping known CNVs in a large Australian schizophrenia sample

Bryan Mowry, Elizabeth Holliday, Peter Visscher, Matthew Brown, Stephen Rose, Christos Pantelis

1,052,100

Project Grant Improving the assessment of brain tumour treatment outcome using 18F-FDOPA PET-MRI

Stephen Rose, Stuart Crozier, Olivier Salvado, Alan Coulthard, Paul Thomas, Michael Fay, Craig Winter, Pierrick Bourgeat

637,125

Project Grant Improving cancer management by direct detection with diffusion-weighted magnetic resonance imaging.

R Bourne, W Price, Gary Cowin, Nyoman Kurniawan, Carl Power, Timothy Stait-Gardner, Viktor Vegh

407,250

Project Grant

The SNORE-ASA study: a Study of Neurocognitive Outcomes, Radiological and retinal Effects of Aspirin in Sleep Apnoea

E Storey, S Ward, R Woods, G Hamilton, A Janke, R Kawasaki, M Naughton

850,000

Project Grant

The development of innovative Multiplexed Molecular Imaging technology targeting improved diagnostic imaging of Glioblastoma Multiforme

Rose, Boyd, Whittaker, Thomas, Fay, Fisk

779,850

Project Grant

Rational development of novel analgesics for the treatment of chronic pain

Glenn King, Mehdi Mobli 576,010

Project Grant

Simultaneous Imaging and Drug Delivery for Prostate Cancer Theranostics

Professor Pamela Russell, Prof Andrew Whittaker, Dr Kristofer Thurecht

545,362

NHMRC Clinical Training Fellowship

Characterizing memory impairments in temporal lobe epilepsy with functional and structural brain imaging

J Hocking 369,102

NHMRC Early Career Fellowship

Investigations of mechanisms underlying autonomic cardiovascular regulation in medial temporal lobe epilepsy.

Marcus Gray 89,891

NHMRC Program Grant Neurobiology of Human Epilepsy: Genes, cellular mechanisms and whole brain

Prof D Reutens, Prof S Berkovic, Prof G Jackson, Prof J Gecz, Prof A Connelly, Prof I Scheffer, Dr S Petrou, Dr Le M Dibben, Dr F Calamante,A/Prof P Thomas

16,450,000

2012 Annual Report


Other Grant Schemes

Australian Cancer Research Foundation

ACRF Molecular Oncology Translational Imaging Facility

Fisk, Rose, Whittaker, Fay, Thomas et al.

2,000,000

Brain Foundation - 2010 Research Grant

Memory function in temporal lobe epilepsy assessed using functional MRI

Julia Hocking, David Reutens 36,300

Ataxia Telangiectasia Foundation

Investigating connectivity and neuroinflammation within corticomotor networks in ataxia-telangiectasia: Improving our understanding of the clinical phenotype

Stephen Rose, Kate Sinclair, Martin Lavin

30,286

Cancer Australia Improving the Assessment of Brain Tumour Treatment Outcome using 18F-FDOPA PET-MRI

Stephen Rose, Stuart Crozier, Olivier Salvados, Alan Coulthard, Paul Thomas, Michael Fay, Craig Winter, Pierrick Bourgeat

828,262

DAAD German Academic Exchange Service Graeme Hanson 968,877

Foundation Jerome Lejeune

Mapping cerebral circuits in Down syndrome

Randal Moldrich, Andrea Guzzetta 28,156

Go8 Australia - Germany Research Co-operation

Whole Human Brain Mapping using Combined MRI and Histology

Prof David Reutens, Dr Steven Yang, Stacey Coles, Asst/Prof Martin Walter

10,000

National Heart Foundation Australia

Nature and Timing of Inflamation after acute ischaemic stroke

Pamela McCombe, Judith Greer, Stephen Read, Stephen Rose, Robert Henderson

113,520

NeCTAR The Characterisation Virtual Laboratory Andrew Janke 491,000

NIH

A population-based atlas of the zebrafish brain for quantitative phenotypic comparisons of disease models

Jeremy Ullmann, Steven Yang, Nyoman Kurniawan, Andrew Janke, Wullimann, & David Reutens

76,509

Queensland Government - NIRAP

Alzheimer's Disease: Novel MRI Biomarkers for Clinical Diagnosis and Translational Studies

Smith, Coulson, Andrew Whittaker, Stephen Rose, Ian Brereton

1,620,000

Parkinson's Queensland INC

Cognitive sequelae in Parkinson’s disease: Identifying the neural substrates

Anthony Angwin, David Copland, Katie McMahon

20,000

Queensland Cyber Infrastructure Foundation Limited

AP16 Brain Mapping National Resource

Andrew Janke, Jeremy Ullman, Graham Galloway, George Paxinos, Charles Watson, Chris Goodnow

376,200

Queensland DEEDI The Centre for Advanced Imaging, EIF David Reutens 2,200,000

2012 Annual Report


Queensland Government- NCRIS

National Collaborative Research Infrastructure Strategy (NCRIS) - Capability Area 5.3 Characterisation (Sub capability - Imaging)

Graham Galloway, Ian Brereton, Perry Bartlett

2,997,500

Qld Government- Smart State National and International Research Alliances

Spinal cord repair

Andrew Whittaker, Firas Rasoul, John Forsythe, Eve Tsai, Ian Brereton, David Nisbet, George Simon, Bronwin Dargaville

1,050,000

Science and Industry Endowment Fund, J Stocker Postdoctoral fellowship, CSIRO

Genetic influences on brain functional and structural connectivity

Dr O Salvado, Dr M Wright, G de Zubicaray, K McMahon, N Martin.

The Wesley Research Institute

An analysis of MRI and ultrasound characteristics of patella dislocation pre and post medial patellofemoral ligament reconstruction

Dr Mark Richardson, Ian Brereton and Gail Durbridge

18,000

Uniquest

Micro PET/CT imaging of a therapeutic antibody

Dr Karine Mardon, Prof Graham Galloway, Prof Ian Brereton, Dr Gary Cowin

51,353

The Wesley Research Institute

Predicting recovery of language and communication after stroke using neuroimaging

Katie McMahon, David Copland, Stephen Read

93,500

University of Queensland

UQ Resteach Katie McMahon

47,931

UQ Resteach Firas Rasoul

55,267

UQ Resteach Nyoman Kurniawan

72,147

UQ CIEF

System to Synapse: a small animal imaging suite

Jeremy Ullmann, Andrew Janke, R Webb, GP Lachlan, P Bartlett, Ian Brereton, David Reutens

70,000

UQ CIEF

New multi-arm hybrid nanoparticles for the improvement of mechanical and antibacterial properties of Glass Ionomer Cement

Firas Rasoul, Laurence Walsh, Anne Symons

73,361

UQ FirstLink System to Synapse - Multi-modal morphometric analysis

Andrew Janke, Jeremy Ullmann, Prof Ian Brereton, Prof graham Galloway, Prof Charles Watson (Curtin), Richard Webb, Prof David Reutens

4,500

UQ New Staff Research Start-Up Fund

Development of a new non-invasive imaging biomarkers for epileptogenesis in a mouse model of temporal lobe epilepsy

Irina Kharatishvili 12,000

2012 Annual Report



Evaluation of benzothiazole derivatives drugs for use as markers of Beta amyloid in the brain

Karine Mardon 12,000


Computational model of Human Brain Hemodynamic response and its heritability using fMRI

Zuyao Shan 12,000

UQ Postdoctoral Research Fellowship UQPRF

Investigations of mechanisms underlying autonomic cardiovascular regulation in medial temporal lobe epilepsy

Marcus Gray 311,303

UQ Postdoctoral Research Fellowship UQPRF

Structural and functional studies of ADD/FLIP complexes that regulate death receptor-mediated apoptosis

Caroline Mas, Ian Brereton, Justine Hill

270,899

2012 Annual Report


Research Higher Degree Students

In 2012 7 RHD students co-supervised at CAI were awarded their degrees

Gabriella Blokland “Genetics of brain structure and function”, September 2012

Ben Brooks “Development of aspects of magnetic resonance imaging to radiotherapy treatment planning of prostate cancer”, September 2012

Shiree Heath “The neurocognitive substrates of naming facilitation in aphasia: an fMRI investigation”, September 2012. Shiree was also awarded the Dean’s Award for Research Higher Degree Excellence 2012

Hui Hui Lee “Novel hydrogelators for the creation of supramolecular self-healing hydrogels as artificial vitreous substitutes”, October 2012.

Geety Nabil “Vaccine development for streptococcis using complement C5a agonist as a molecular adjuvant” September 2012

Abdalrahman Al-Salihi “Does whole liver determination of liver steatosis improve accuracy?” November 2012.

Oliver Squires “The production of novel fluorinated contrast agents for magnetic resonance imaging”, July 2012

Baptiste Duchesn-Couvey, Masters Externship “Heritability of head motion during resting state functional MRI in 462 healthy twins”, August 2012.

Centre staff co-supervised the following RHD students in 2012.

Student Name Enrolling School

Abdalrahman Al Sahili School of Medicine - South

Qurain Al Shammari School of Medicine - South

Othman Al Omair School of Pharmacy

Eid Alosime AIBN

Gabriella Blokland Psychology

Nathan Boase AIBN

Jessica Cameron AIBN

Jeiran Choupan QBI

Ya-Mi Chuang AIBN

Robert Coleman SCMB

Jorja Cork SCMB

Qianyun Du SCMB

Jiaxin Du QBI

Gail Durbridge School of Medicine

Nahla Faizo QBI

2012 Annual Report


Nicolas Fletcher AIBN

Wanli Johnny Fu AIBN

Yaqin Han School of Pharmacy

Shiree Heath SHRS

Georg Kerbler QBI

Taraneh Khoo School of Medicine - North

Jacov Kulis AIBN

Jennifer Leech School of Biomedical Sciences

Hui Hui Lee-Wang AIBN

Chunli Liu AIBN

Paul Luckman AIBN

Andrew Martin QBI

Jarad Martin School of Medicine - North

Dennis Murray LCAFS

Truong Giang Nguyen QBI

Hien Duy Nguyen School of Maths and Physics

Huey Wen Ooi AIBN

Kerstin Pannek School of Medicine - North

Matthew Roberts School of Medicine - North

Alicia Rowlings SHRS

Tracy Roxbury SHRS

Miriem Santander Borrego AIBN

Simon Scheck School of Medicine - North

Farshid Sepehrband QBI

Ben Sinclair Psychology

Mohammad Ullah SCMB

Sophie Van Hees SHRS

Srini Varanasi Dentistry

Kewei Wang AIBN

Michael Westphal SCMB

Rebecca Williams QBI

Craig Winter School of Medicine - North

Jing Zhang School of Biomedical Sciences

2012 Annual Report


Honours Students

Tess Evans, “Plasticity in axonal connectivity in mice with partial agenesis of the corpus callosum”

Joshua Harbort, “Dynamic Nuclear Polarisation”

Megan Isaacs, “Neural Correlates of Rapid New Word Learning: A Structural Imaging Study of Healthy Adults”

2012 Annual Report


CAI Education Programs The CAI provides a number of education programs including postgraduate coursework in Magnetic Resonance Technology (MRT), short courses and summer scholarships. Student enrolments increased across all courses in 2012, with noticeable growth in international student participation, particularly in MRT.

Average student enrolment numbers for MRT

In 2012, the CAI’s education facilities were expanded as part of the new building. The changes included a new space for delivering MRT tutorials, making it easier to accommodate the expanding class sizes.

The tutorial experience has also been enhanced by new facilities such as interactive white boards, the ability to save and email tutorial whiteboard notes and seamless transition between various computer functionalities.

Postgraduate Coursework

Magnetic Resonance Technology (MRT) postgraduate programs have been designed for radiographers, biomedical engineers and other health professionals working with Magnetic Resonance Imaging equipment. The programs are enrolled through the Faculty of Science and include:

· Graduate Certificate in Magnetic Resonance Technology (GCMagResonTech);

· Postgraduate Diploma in Magnetic Resonance Technology (GDipMagResonTech); and

· Master of Magnetic Resonance Technology (MMagResonTech).

The elective courses in the programs allow students to tailor their learning according to their interests and needs. Two new elective courses were developed in 2012:

• Advanced Research Project (MRES7018, 6 credit points) allows students to engage in small research projects in conjunction with a CAI supervisor. It is the first of CAI’s courses to have a compulsory two week residential component, giving students access to world class imaging facilities and teaching staff.

0

5

10

15

20

25

30

35

40

45

50

2010 2011 2012

Grad Cert.

Grad. Diploma

Masters

2012 Annual Report

http://www.uq.edu.au/study/program.html?acad_prog=5036




• Medical Image Processing and Analysis (MRES7023, 2 credit points) was developed to address the increasing

complexity and volume of images generated on modern equipment, particularly multimodal systems such PET/CT and MRI/PET.

Graduate Certificate Semester 1 Semester 2

Domestic 27 29

Total: 27 29

Masters by Coursework

Domestic 15 11

International 34 34

Total: 49 45

Postgraduate/Graduate Diploma

Domestic 21 21

Total: 21 21

2012 MRT Program Total 97 95

Average student enrolment numbers for MRT

Short Courses

The CAI has developed a series of practical short courses aimed at health professionals who wish to experience magnetic resonance scanning directly. The courses are taught by radiographers, physicists and doctors, and all the short courses attract CPD (Continuing Professional Development) points from both AIR (Australian Institute of Radiography) and RANZCR (Royal Australian and New Zealand College of Radiologists).

In 2012, a Spectroscopy Short Course was held, with 7 participants.

Undergraduate Scholarships The CAI offers several scholarships for the summer and winter vacations in partnership with the Undergraduate Office. The scholarships are for a maximum of ten weeks. The CAI hosted 4 undergraduate scholars in 2012.

Outreach education Centre staff participate in a number of outreach teaching and education programs, with secondary school visits to CAI. Continued professional development through linkages with commercial development in NMR and MRI is enhanced by activities such as Dr Katie McMahon participating as an invited tutor at Siemens IDEA course in Melbourne 2012.

2012 Annual Report


External Engagement

National Imaging Facility

The National Imaging Facility (NIF) is an imaging technology-based national network that provides state-of-the-art imaging and analysis capabilities for animals, plants, and materials. NIF now has 10 nodes across Australia, delivering MRI, PET, CT, ultrasound and live animal optical imaging to the Australian research community. NIF’s sixty scientists and staff include biologists, neuroscientists, imaging researchers and clinicians, material scientists, platform engineers and computational scientists offering a multi-disciplinary and collaborative imaging solutions.

In late 2012, NIF was further granted with $4.3 Million funding as a result of the successful application in the competitive new CRIS funding program (Collaborative Research Infrastructure Scheme). This augments earlier NIF funding from the National Collaborative Research Infrastructure Strategy (NCRIS) and the Education Investment Fund (EIF).

The Centre for Advanced Imaging (CAI) at the University of Queensland hosts the largest Node of NIF and is also the base of NIF Central Management. With Prof. Ian Brereton being the Node Director, the UQ Node hosts several state-of-the-art imaging technology capabilities as outlined in the facilities section of this report.

The National Imaging Facility is an integral member of the Australian National Characterisation Council, together with the Australian Synchrotron, Australian Microscopy and Microanalysis Research Facility (AMMRF), and Australian Nuclear Science & Technology Organisation (ANSTO).

2012 Update (UQ Node):

Acquisition of World’s First Commercial Preclinical MR/PET Imaging Scanner

In late 2012, the world’s first commercial imaging prototype that combines Magnetic Resonance (MR) and Positron Emission Tomography (PET) imaging technologies from Bruker Biospin, Germany, was installed at the UQ Node as a flagship imaging capability. This system is described in more detail in the Facilities section of this report.

Members of the NIF-UQ Node (L – R): Prof. Ian Brereton (UQ Node Director), Dr Andrew Janke (Informatics Fellow), Dr Karine Mardon and Dr Gary Cowin (Facility Fellows)

2012 Annual Report


Collaboration on Avocado Bruising

With consumers consistently disappointed by the poor internal quality of avocado fruit, a major issue for avocado growers and suppliers is understanding how the flesh of the fruit bruise. In collaboration with the UQ School of Agriculture and Food Sciences and Avocados Australia Limited, imaging experts at the NIF-UQ Node, Prof. Ian Brereton and Dr Gary Cowin, have utilised non-destructive 3T MRI imaging technology to characterise at the cellular and tissue level the mechanisms of mechanical injury expression as visible flesh bruising, in ripening avocados. This has enabled the first detailed supply chain investigation of the relationship between handling and ripeness of avocado fruit.

3T MRI images of ripened avocados.

TissueStack: Digital Imaging Processing

Supported by the Australian National Data Service (ANDS), Dr Andrew Janke, Informatics Fellow at the NIF-UQ Node, and his team have been developing TissueStack, an integrated web-based digital imaging processing service. The objective of the system is to automate the direct data tiling, accelerate querying of imaging measurement, and display high level of images with three dimensions in real world coordinates.

Digital Imaging Processing (DIP) plays an important role in the analysis, interpretation and modification of digital data for improved image qualities. It is a rapidly evolving area due to the technological advances in digital imaging, computer processors and mass storage devices. DIP maximises the details of image extraction and analysis, but also provides the capability of capturing the raw data for further study and interpretation. DIP and information extraction from images have also become indispensable aspects of the experimental workflow in medical science research, particularly in cell biology and neuroscience.

The TissueStack project is supported by the Australian National Data Service (ANDS). ANDS is supported by the Australian Government through the National Collaborative Research Infrastructure Strategy Program and the Education Investment Fund (EIF) Super Science Initiative.

2012 Annual Report


Queensland NMR Network NMR spectroscopy is a key platform technology for characterisation and makes substantial contributions to the

Australian National Research Priorities. To enhance Queensland’s capabilities in NMR and MRI, the Queensland Nuclear

Magnetic Resonance Network (QNN) was funded in 2006 with assistance from the Smart State Research Facilities Fund

(SSRFF). QNN is a network of high field NMR equipment that supports fundamental research, applied bioscience and

the developing biotechnology industry in Queensland. The facility allows researchers from universities, institutes and

companies to carry out high-resolution molecular structure determination and imaging in support of research programs

in a broad range of fields, including biodiscovery, drug design, and neuroscience. The facility attracts national and

international researchers and establishes Queensland as a central hub for NMR spectroscopy and imaging research in

Australia.

Participant organisations in QNN are UQ, Griffith University and Queensland University of Technology. The Centre for

Advanced Imaging has administrative and operational management responsibility for the QNN and for its facilities

located at UQ.

The QNN maintained its high research productivity throughout 2012 as highlighted by 49 refereed publications and 42

conference presentations by QNN facility users. 2012 saw 16 new research grant projects begin along with the

enrolment of 9 new PhD students. Grant funds awarded for 2012 were maintained at levels similar to 2011 with a total

of $6.7 million and all current research grants associated with the QNN reached $23.4 million, in addition to funding of

two ARC Centres of Excellence at $28.1 million. Seven new grants awarded to begin in 2013 total $2.052 million.

Research highlights at UQ arising from QNN activities during 2012 included outcomes from a number of major programs

that make use of the facilities. These included:

• The publication in the prestigious journal, Science, of an application of NMR metabolomics undertaken

by Dr Horst Schirra (CAI) and co-workers at UQ in the study of the role of a core enzyme in the mediation

of resistance to phosphine gas, an important fumigant in the control of grain pests.

• Imaging research describing the efficacy of intravenous immunoglobulin preparations as a

neuroprotective agent against neuronal apoptosis in stroke and Alzheimer’s disease has led to Phase 1

clinical trials of the method in the USA in 2012.

• Award of a prestigious NHMRC Senior Principal Research Fellowship to Professor David Craik at the

Institute for Molecular Bioscience at UQ to continue his ground breaking research program in to the

structure, function and pharmaceutical application of a new class of proteins known as cyclotides

previously discovered by Prof Craik.

2012 Annual Report


CAI Operations Construction of the new CAI building

2012 saw the completion of the first stage of the CAI building in August. Designed by John Wardle Architects and Wilson Architects, Architects in Association the building will ultimately house 120 staff and students, seven instrument suits, new radiochemistry and PC2 laboratories, animal handling rooms and engineering spaces.

The first stage of the building contains over 500m3 of concrete (83 trucks worth), with a special concrete blend uniquely designed for the cyclotron bunker being sourced from a quarry in Warwick.

Facilities

In 2012, the CAI’s facilities were expanded with the installation of the world’s first commercial preclinical magnetic resonance/positron emission tomography (MR/PET) imaging scanner. The system, from Bruker Biospin (Germany), allows simultaneous acquisition of MRI and PET images of an animal or sample. The technology combines the exquisite structural and functional characterisation of tissue provided by MRI with the extreme sensitivity of PET metabolic imaging and tracking of uniquely labelled cell types or cell receptors. The MRI system is comprised of a 7 Tesla, 300 mm bore superconducting magnet, with operating software identical to the Siemens clinical MRI platform. This enables the most direct translation of research outcomes from animals to humans, benefitting a wide range of medical and scientific research. The PET insert has been developed to provide optimal performance in the high magnetic field of the MRI system. The flagship MR/PET was funded as part of the National Collaborative Research Infrastructure Strategy (NCRIS) and forms part of the National Imaging Facility.

2012 has also seen the expansion of CAI’s preclinical imaging capacity through the relocation into enlarged facilities in the new building. There is now a floor dedicated to preclinical imaging including animal rooms and tissue handling facilities. During the move, the Avance 16.4T microimaging system was upgraded to ensure compatibility with new operating systems. The PC2 facility is expected to be operational in September 2013.

The CAI would like to acknowledge the demise of the Magnex 17.1Tesla magnet of the 750 high-resolution NMR spectrometer. This system has been a valuable asset to the University since it was installed in January 1996. Its installation was funded by what was, at the time, the ARC's largest single equipment grant. Since then, the system served the Centre and University researchers well and remained Australia's highest field NMR magnet until 2004. As a result of the CAI building project, and due to the machine’s large stray field, the 750 has made way for a new actively shielded 700, which is optimised for metabolomic research programs. It was hoped that the 750 could remain in service elsewhere but with the magnet vacuum softening and unavailability of charging equipment, the cryogens were left to slowly boil off and after a few weeks, the magnet quenched.

2012 Annual Report


Overview of Facilities

The CAI’s resources enable imaging from the molecular scale to whole body imaging and have application in disciplines as diverse as nanomaterials and neurobiology. CAI’s facilities are also compatible with the growing field of functional magnetic resonance imaging (fMRI).

Magnetic Resonance Imaging (MRI) is a key technology for determining the structures of molecules and visualising the anatomy of living tissue and microscopic structure. MRI techniques have revolutionised chemistry, physics, diagnostic medicine and structural biology. Nuclear Magnetic Resonance (NMR) is utilised for complete determination of the structure of proteins, providing the fundamental molecular information used in drug design programs. Electron pulsed resonance (EPR) is complementary to NMR and is used for the characterisation of the molecular structure of paramagnetic and diamagnetic materials and molecules.

Imaging techniques are also invaluable for studying the structure and function, in health and disease, of living organisms from the laboratory mouse to the human. The ability of ultra high-field magnetic resonance imaging (MRI) to characterise the blood flow and structure of living systems, together with developments in MRI biomarkers, allows researchers to better phenotype animal models of disease and to map the cognitive function of the brain. Positron emission tomography (PET) measures the distribution and fate of molecular markers using radiolabelled ligands providing researchers with the capacity to perform in vivo studies of metabolism, receptor-ligand binding and gene expression. The ability to study the living organism enables longitudinal studies of normal development, of the natural history of disease and of responses to novel therapies.

Imaging is a platform technology for drug discovery and validation, providing surrogate end points to test new drugs. It speeds translation of scientific discoveries to clinical realisation. MRI and PET are now core investigative modalities in the majority of clinical specialties. Imaging facilitates the goal of personalised medicine by better characterising disease and response to treatment in the individual patient.

High Resolution NMR Spectroscopy

The high resolution NMR facility at CAI caters for spectroscopic investigations in solution with applications across the chemical, biochemical and physical sciences. High resolution NMR is used to provide high resolution, three-dimensional structural analysis of both membrane-bound and free molecules and polymers in solution and can also be used for metabolomics studies.

The 900MHz Bio NMR is the highest field system available in Australia. This instrument is optimised for biomolecular studies and is equipped with a Cryoprobe to enhance sensitivity. It provides high-resolution, three-dimensional structures of membrane proteins, complex carbohydrates, nucleic acids, protein-protein complexes and enables mapping of macromolecular interactions, all of which cannot be achieved on lower field systems. With the increased resolution and sensitivity of this high field magnet, identification of low concentration metabolites can be achieved, leading to the identification of new biomarkers.

The Avance II 500MHz high-resolution NMR spectrometer is used for the study of small to intermediate-sized molecules, for synthetic polymers, kinetics, multi-nuclear NMR and materials research. An upgrade to an Avance III HD spectrometer console is due for completion in March 2013. This system will have a new Smart broadband probe with capabilities for 19F NMR, which is important for the development of fluorinated MRI contrast agents.

The Avance III 300 MHz NMR spectrometer, interfaced to a 7.41T 89 mm bore magnet system, is used for both routine solid-state NMR analysis, and advanced analysis and technique development.

2012 Annual Report


Micro Imaging

To support microimaging, the new CAI building has PC2 laboratories with sample preparation areas and animal surgery and holding rooms. The CAI operates Bruker spectrometers dedicated to microimaging.

The DRX 300 MHz NMR spectrometer is interfaced to a 7.41T 150 mm bore magnet system. This spectrometer is used for high-resolution small object imaging and rheology.

The 700 MHz wide-bore Avance 16.4T microimaging system is capable of providing extremely detailed images of intact biological specimens. This spectrometer allows live mouse, fixed tissue and solid sample imaging from 4mm to 30mm diameter. Probes are available for imaging proton, fluorine and carbon. The scanner was successfully relocated in September 2012 to the new CAI building and is now fully operational.

The 16.4T’s scanner console computer was upgraded in 2012 with the Dell Precision Workstation with 12 cores, 32 GB memory, 64-bit Centos 5.6 and Paravision 5.1. This new console enables much faster processing of data reconstruction and stability. The increased memory and processor number will enable processing of much higher of data acquisition matrix (currently limited to a maximum of 512x256x256), ready to take the advantage of future ParaVision 6 releases.

The 16.4T scanner is also one of the Centre’s main pre-clinical animal scanners.

Animal Imaging

2012 has seen the expansion of preclinical imaging capacity through the delivery of new equipment and the relocation into expanded facilities in the new building. With a floor dedicated to preclinical imaging including animal rooms, tissue handling facilities and additional instruments due in 2013, CAI will have an extensive suite of animal scanners available for use.

The 7T ClinScan MRI system was installed during 2012. This system is unique as it is the first preclinical MRI system in Australia that used the Siemens clinical operating system, used on all hospital systems.. Running the Siemens operating system allows the most direct translation of animal imaging results to human scanning on CAI’s 3T and future 7T human system. This Bruker ClinScan will also be the world’s first commercial prototype of a combined MRI/PET system following the installation of the dedicated PET ring that will be installed in 2013.

Molecular Imaging

Positron Emission Tomography (PET) is a molecular imaging modality that requires the administration of a radiolabelled probe or radiopharmaceutical. When combined with Computerised Tomography (CT), a powerful multimodality imaging system is formed providing researchers with information on both function and structure.

CAIs Inveon PET/CT imaging scanner (Siemens) was relocated to the CAI new building in September 2012. The scanner is capable of providing three-dimensional CT and PET images of live mouse and rat and fixed samples. The system can deliver high-resolution CT images (<10 µM for a field-of-view <20mm) with a maximum field-of-view of 80 mm X 50 mm (with a resolution of approximately 50 µM). The CT scanner has proved to be valuable instrumentation in a wide range of scientific applications from biomedical imaging, biological sciences, material science and environment science. The minimum resolution achievable with the PET scanner is approximately 1 mm (maximum field-of-view of 120 mm) with a high sensitivity in picomolar range. The imaging probes used in PET are labelled with positron-emitting radionuclides produced by a cyclotron (i.e. 18F, 11C, 64Cu, 124I). The new radiochemistry facilities and cyclotron complement the preclinical PET/CT at the CAI enabling PET imaging probes to be manufactured and tested in-house. This is particularly beneficial for probes incorporating short-lived radioisotopes (e.g. 11C with 20 minute half-life).

2012 Annual Report


Cyclotron and Radiochemistry

The CAI is now equipped to conduct research in radiolabelling methodologies, to develop new radiolabelled probes or radiopharmaceuticals, and to produce radiolabelled compounds to support research in molecular imaging. In 2012 the CAI commissioned its new radiochemistry facilities and took delivery of a cyclotron after on-site acceptance testing.

The ‘Cyclone Twin’ 18 MeV dual ion source cyclotron manufactured by Ion Beam Applications (Belgium) has 8 target ports and is equipped with [18F]fluoride, [11C]carbon dioxide, [11C]methane, and [13N]nitrogen targetry along with an external beam line and solid target station for radioisotope production including [124I]iodine and [64Cu]copper. A suite of 14 hot-cells housing 10 automated radiochemistry modules for the manufacture of radiolabelled compounds to Good Manufacturing Practice (GMP) standards, are installed in the radiochemistry laboratories and include laminar flow isolators for radiopharmaceutical dispensing, and a specialised hot-cell equipped with tele-manipulators for solid target processing. The radiochemistry modules include three ‘MeI-Plus-CO2’ and a ‘MeI-Plus-CH4’ modules for [11C]methyl iodide synthesis and subsequent radiolabelling , two nucleophilic [18F]radio-fluorination modules (Synthra, Germany), and a further four [18F]radio-fluorination modules that employ disposable cassettes (Synthera, Belgium) to facilitate efficient routine manufacture of radiopharmaceuticals.

Human Whole Body MRI Scanners

The CAI houses one of the most comprehensive ranges of whole-body scanners available to researchers in Australia. Ranging from neurology, cardiology, angiography, oncology, musculoskeletal studies, to paediatrics and engineering, research is conducted on state-of-the-art equipment, with access to world-class expertise.

The Magnetom Trio 3T system, with Tim (Total Imaging Matrix), incorporates the latest technology, for neuro, whole-body and peripheral imaging. The system comes complete with a wide range of coils and software for applications in neurology, cardiology, angiography, oncology, orthopaedics and paediatrics, and includes a development environment for new sequence and hardware development. Parallel acquisition acceleration is standard, with a 32-channel head coil and up to 12-channels for body imaging.

The Trio 3T includes a range of response devices including eye tracking and motion tracking, physiological monitoring and simultaneous EEG.

The hardware for non-proton imaging and spectroscopy is provided, and Hyperpolarised 3He imaging will be implemented shortly. Other nuclei will be considered, on request.

Situated at the Wesley Hospital, the Medspec 4T clinical imaging system is dedicated to the research program of The University of Queensland and relies on interaction with the clinicians from University departments and from the hospital. This instrument is principally used for neuroimaging and features a PC and projector for delivery of cognitive paradigms. It also includes a variety of response devices.

The increased SNR (Signal to Noise Ratio) offered by ultra-high field is being used in proton imaging to improve the spatial resolution in images of the temporal lobe of the brain, as part of the study of cognitive impairment. Functional

Did You Know?

• In 2012, CAI researchers scanned more than 2,500 participants for research purposes.

• The age of MRI research participants ranged from 3.5 to 85 years.

2012 Annual Report


MRI benefits from improved SNR and improved contrast, while spectroscopy benefits from improved spectral dispersion.

The Siemens 1.5T scanner is owned in collaboration with the Wesley Hospital. Equipped with Sonata Gradients capable of 40mT/m, with a slew rate of 200T/m/s, 50% of the available time is devoted to research projects. It has an extensive range of anatomy and application-specific radiofrequency coils, as well as most of the currently used imaging sequences. Cooperation agreements with Siemens Medical Systems provide University research staff with the ability to develop new imaging sequences.

The systems are configured with the latest parallel imaging technology, and are used extensively for musculoskeletal, cardiac, functional brain imaging, and clinical breast imaging. The systems are suitable for multi-site clinical studies.

High Resolution EPR Spectroscopy

Continuous wave EPR spectroscopy (CW EPR) has been widely used to structurally characterise paramagnetic molecules such as free radicals, multi-atom clusters, high Tc superconductors, organic molecular ferromagnets, catalysts, transition metal ion complexes and metalloproteins found in such diverse areas as nanomaterials, solid state physics, geology, materials science, inorganic, organic and polymer chemistry, biochemistry, pharmacy, food science, radiation dosimetry and medicine. Non-invasive EPR imaging offers the capacity to spatially locate paramagnetic molecules within small animals and bulk materials.

Dynamic Nuclear Polarisation (DNP) provides enhanced NMR and MRI sensitivity through transfer of polarisation from electron spins to nuclei. CAI has developed a low frequency DNP polariser for enhancing the sensitivity of NMR and MRI experiments in the areas of structural biology and medicine. Relevant facilities within the CAI include:

• a Bruker Elexsys E500 CW (Q-, X-, S-band) variable temperature (1.5-400K) EPR Spectrometer; • a Bruker Elexsys E580 Pulsed (Q-, X-band) variable temperature (1.5-300K) EPR/ENDOR/ELDOR Spectrometer; • a Low frequency Dynamic Nuclear Polarisation (DNP) Spectrometer incorporating an X-band Bruker EPR

Spectrometer; • a Bruker Elexsys E540 (X-, L-band) Imaging Scanner; and • EPR software (XSophe, Molecular Sophe) for the analysis of CW and pulsed EPR/ENDOR spectra.

Mid to late September the continuous wave (CW) and pulsed EPR spectrometers were shutdown, packed and moved temporarily to D-Block at the UQ Long Pocket Campus, while the new EPR laboratory in the Centre for Advanced Imaging and the 2nd floor Gehrmann chemistry laboratories were being built. Due to a number of technical issues, the EPR facilities were offline for the remainder of 2012. We are eagerly awaiting the move to the new EPR laboratory in the CAI, scheduled for July 2013.

2012 Annual Report


Occupational Health and Safety 2012 was a very busy year for occupational health and safety (OHS) at CAI, with the greatest challenge being the move into the new CAI building. The move required the implementation of new policies and procedures, in addition to the supervision of ongoing building works and the arrival and commissioning of equipment. Existing regulatory systems were also heightened by the implementation of new online facility access procedures and tracking of regulatory compliance. The move into the new building ran safely and smoothly, with the OHS committee reviewing emergency procedures, identifying potential new hazardous areas and implementing new training procedures well in advance. A new building induction process was developed and attended by all staff and students. The implementation of new systems allowed contractors to work under supervision in hazardous laboratory areas, as well as other areas requiring maintenance. The arrival of new equipment, such as the cyclotron and the commission of the radiochemistry facilities were significant activities for the CAI OHS Manager, Simon Nevin, and the UQ Radiation Safety Advisor, Vic Leach. Specific regulatory permits were required, installation personnel needed supervision and pertinent policies and procedures were drafted. 2012 also saw the development of the CAI intranet to track all UQ Safety training records and to systematically monitor compliance with various regulatory bodies and legislation. Online CAI Facility access procedures were also developed, incorporating risk assessments and standard operating procedures. These changes ensured all staff and students working at CAI complete and acknowledge their understanding of all relevant safety training before access is granted. The CAI OHS committee met nine times in 2012, four minor incidents were reported and the committee updated relevant policies. CAI is now directly represented at the UQ OHS council by CAI’s OHS Manager. The OHS Committee supervised the required annual audits and the decommissioning of the Gehrmann PC2 laboratory.

2012 Annual Report


Professional Presentations and Awards

Editorial Board Participation Applied Magnetic Resonance Graeme Hanson Concepts in Magnetic Resonance (Part B: Magnetic Resonance Engineering) Viktor Vegh Frontiers in Neuroinformatics

Graham Galloway ISRN Structural Biology Horst Schirra Journal of Applied Polymer Science Andrew Whittaker Journal of Inorganic Biochemistry

Graeme Hanson

Macromolecules Andrew Whittaker Magnetic Resonance in Medicine

Graham Galloway Metabolites

Horst Schirra

PLoS One Marcus Gray

Structural Biology Horst Schirra Radiation Physics and Chemistry Andrew Whittaker

2012 Annual Report


Conference Presentations

Othman Al Omair In vivo High Angular Resolution Diffusion Imaging at 16.4 Tesla. ISMRM 2012, Melbourne.

Idriss Blakey 33rd Australasian Polymer Symposium. Hobart, Tasmania, February 12-15, 2012. “Using Hyperbranched Polymers for Surface Modification: Towards the Facile Self Assembly of Sensing Devices”

Colloids and Nanomedicine 2012. Amsterdam, The Netherlands, 15-17 July 2012. “Constructs for optical biomedical imaging agents : Controlling the optical properties of polymer stabilized gold nanoparticle aggregates“

2012 International Symposium on Extreme Ultraviolet Lithography. Brussels, Belgium 30 September – 4 October 2012. “Development of DSA Approaches for Healing of LER and Shrinking of CD that are Compatible with Standard EUV Resists”

Graham Galloway Asia-Pacific Microscopy Conference, Perth – February 2012;

Invited Speaker and Session Chair, UWS Symposium on MRI and Diffusion 2012

Nyoman Kurniawan Validation of Diffusion-Weighted FMRI signal in vitro using brain slices. ISMRM 2012, Melbourne.

Visualization of prostate fibromuscular stromal matrix using ex-vivo high-resolution DTI tractography. ISMRM 2012, Melbourne.

The effect of coil types and GRAPPA acceleration in HARDI and probabilistic fibertracking. ISMRM 2013, Salt Lake City US.

Andrew Janke TissueStack: a new way to view your imaging data. In proceedings INCF 2012, Munich, Germany.

15μm average mouse models in Waxholm space from 16.4T 30μm images. In 20th Annual ISMRM Scientific Meeting and Exhibition, Melbourne, Australia.

Karine Mardon Comparison of ultra-high resolution micro-CT and micro-MRI of mice brain and cerebral vessels. Dublin, September 2012

Katie McMahon MR Essentials symposium, RADaim, “MR Fundamentals”, “Parallel Imaging” and “Pulse Sequences”

David Reutens Chair. Establishment of an Australian Society for Molecular Imaging. Molecular Imaging Symposium. Sydney 1 May 2012.

Twin studies of the hemodynamic response function. Symposium on Brainnetome Meets Genome. Brisbane 3-4 May 2012. High field animal MR imaging. ANS 2012 Satellite Symposium on Imaging. Brisbane 28-29 January 2012

2012 Annual Report


5HT1A receptor imaging with MPPF. Molecular Imaging Symposium. Sydney 1 May 2012. Imaging Research at the Centre for Advanced Imaging, Clinical Neurology Symposium. Sydney 20-21 April 2013.

Zuyao Shan Biomarkers of epileptogenesis in temporal lobe epilepsy: Quantitative MRI and EEG. ISMRM 2012, Melbourne.

Horst Schirra Less mice more men - work on using NMR-based metabolomics to build a bridge between systems biology and classical science. Institute for Genomic Medicine, University Regensburg, Germany.

Of Mice and Men - NMR-based metabolomics between systems biology and clinical science. Bürgerspital Solothurn, Switzerland.

Of Mice and Men - NMR-based metabolomics between systems biology and clinical science. Australia and New Zealand Society of Nephrology 48th Annual Scientific Meeting, Auckland, New Zealand.

A Mammalian Menagerie - NMR-based metabolomics between systems biology and clinical science. Queenstown Molecular Biology Meeting, Queenstown, New Zealand. 24-26 August 2012.

Of Mice and Men - NMR-based metabolomics between systems biology and clinical science. Unversitätsklinikum Tübingen, Tübingen, Germany.

Kristofer Thurecht Invited Speaker - Polymeric theranostics: hyperbranched polymers for diagnosing and treating disease. Australasian Polymer Symposium, Hobart, February 2012.

Hyperbranched polymers in theranostics. Warwick Polymer Chemistry Conference, Warwick, UK, August 2012.

Jeremy Ullmann A segmentation guide and probabilistic atlas of the C57BL/6J mouse brain from magnetic resonance imaging. In proceedings INCF 2012, Munich, Germany. Probabilistic atlas of the C57BL/6J mouse cerebellum. In 20th Annual ISMRM Scientific Meeting and Exhibition, Melbourne, Australia.

Viktor Vegh Application of Weber’s Law to Medical Image Registration to Accommodate Intensity Inhomogeneities. IEEE DICTA, Perth Australia, 4-6 December, 2012.

Andrew Whittaker Novel 19F Molecular Imaging Agents for Cancer Diagnosis, Macro2012, World Polymer Congress, Blacksburg, VA, USA.

MRI Contrast Agents – Current Status and the Way Forward, Sydney International Nanomedicine Conference, Sydney, Australia.

Block Copolymer Healing of Lithographic Defects, International Conference on Emerging Advanced Nanomaterials – 2012, Brisbane, Australia.

2012 Annual Report


Awards

In 2012 a number of CAI staff received recognition for professional activities through the following awards:

Andrew Whittaker

- Member of ARC College of Experts

Karine Mardon

- Siemens preclinical Image of the year competition with the following power point presentation “Comparison of ultra-high resolution micro-CT and micro-MRI of mice brain and cerebral vessels. Karine Mardon, Willy Darmawan and Nyoman Kurniawan. Dublin, September 2012

Kris Thurecht

- Elected Chair, RACI QLD Polymer Group. October 2012.

- QLD Tall Poppy Research Science Award, 2012.

2012 Annual Report


Publications Book Chapter

Barner-Kowollik, C., Blinco, J.Destarac, M. Thurecht, K. & Perrier, S. (2012) Reversible addition fragmentation chain transfer (RAFT) polymerization: mechanism, process and applications. In Chryssostomos Chatgilialoglu, Armido Studer (Eds.), Encyclopedia of radicals in chemistry, biology and materials (pp. 1895-1929). Chichester, West Sussex, U.K.: John Wiley & Sons.

Battersby, B., Chen, A. Kozak, D. & Trau, M. (2012) Biosensors for disease biomarker detection. In Seamus Higson (Eds.), Biosensors for medical applications (pp. 191-216). Oxford, United Kingdom: Woodhead Publishing.

Maciejewski, M., Mobli, M.Schuyler, A. Stern, A. & Hoch, J. (2012) Data sampling in multidimensional NMR: fundamentals and strategies. In Martin Billeter, Vladislav Orekhov (Eds.), Novel sampling approaches in higher dimensional NMR (pp. 49-77). Heidelberg, Germany: Springer.

Tieng, Q. & Vegh, V. (2012) Compact superconducting magnet design for nuclear magnetic resonance: The minimum stored energy approach. In Graham A. Webb (Eds.), Annual reports on NMR spectroscopy (pp. 161-189). Maryland Heights, MO, U.S.A.: Academic Press.

Tregenna-Piggott, P., Noble, C. & Riley, M. (2012) The dynamic Jahn-Teller effect in Cu(II)/MgO. In Mihail Atanasov, Claude Daul, Philip L. W. Tregenna-Piggott (Eds.), Vibronic interactions and the Jahn-Teller effect: theory and applications (pp. 85-103). Dordrecht, Netherlands: Springer.

Conference Paper

Ariens, M., Ullmann, J., Kurniawan, N., Lo, H., Reutens, D. & Vegh, V. (2012). Diffusion weighted imaging of zebrafish embryos using dedicated radio frequency coils. In 20th Annual Meeting of the International Society for Magnetic Resonance in Medicine. 20th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Melbourme, VIC, Australia. 5-11 May 2012.

Brossi, S. & Bradley, A. (2012). A comparison of multiple instance and group based learning. In Geoff West, Peter Kovesi (Eds.), 2012 International Conference On Digital Image Computing Techniques and Applications (Dicta). 14th International Conference on Digital Image Computing Techniques and Applications, DICTA 2012, Fremantle, WA, Australia, (1-8). 3 - 5 December 2012.

Chandra, S., Xia, Y., Engstrom, C., Schwarz, R., Lauer, L., Crozier, S., Salvado, O., Fripp, J (2012). Unilateral Hip Joint Segmentation with Shape Priors Learned From Missing Data. In 9th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro. 9th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro, Barcelona Spain, (1711-1714). May 02-05, 2012.

Cheng, H., Keen, I., Yu, A., Chuang, Y., Blakey, I., Jack, K., Leeson M., Younkin, T., Whittaker, A. (2012). EUVL compatible, LER solutions using functional block copolymers. In William M. Tong, Douglas J. Resnick (Eds.), Proceedings of SPIE - International Society for Optical Engineering. Conference on Alternative Lithographic Technologies IV, San Jose, CA, United States, (83231O.1-83231O.11). 13-16 February 2012.

Daianu, M., Jahanshad, N., Dennis, E., Toga, A., McMahon, K., de Zubicaray, G., Martin, N., Wright, M., Hickie, I., Thompson, P. (2012). Left versus right hemisphere differences in brain connectivity: 4-Tesla HARDI tractography in 569 twins. In 9th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro. 9th IEEE International Symposium on Biomedical Imaging (ISBI) - From Nano to Macro, Barcelona Spain, (526-529). 2 - 5 May 2012.

Dennis, E., Jahanshad, N., Toga, A., Johnson, K., McMahon, K., de Zubicaray, G., Montgomery, G., Martin, N., Wright, M., Thompson, P. (2012). Changes in Anatomical Brain Connectivity Between Ages 12 and 30: A HARDI Study of 484 Adolescents and Adults. In 9th IEEE International Symposium on Biomedical Imaging. 9th IEEE International Symposium on Biomedical Imaging, Barcelona, Spain, (904-907). 2-5 May 2012.

Dennis, E., Jahanshad, N., Toga, A., McMahon, K., de Zubicaray, G., Martin, N., Wright, M., Thompson, M. (2012). Test-retest reliability of graph theory measures of structural brain connectivity. In Nicholas Ayache, Hervé Delingette, Polina Golland, Kensaku Mori (Eds.), Lecture Notes in Computer Science. 15th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2012), Nice, France, (305-312). 1-5 October 2012.

Dore, V., Bourgeat, P., Fripp, J., Acosta, O., Chetelat, G., Szoeke, C., Ellis, KA., Martins, RN., Villemagne, V., Masters, CL., Ames, D., Rowe, CC., Salvado, O. (2012). A Surface Based approach for cortical thickness comparison between PiB plus and PiB- Healthy Control subjects. In Conference on Medical Imaging - Image Processing. Conference on Medical Imaging - Image Processing, San Diego Ca. Feb 06-09, 2012.

Gu, Y., R. & Wang, D. (2012). A comparison between 2D and 3D particle size measurements. In Process Mineralogy '12. Process Mineralogy '12, Cape Town, South Africa. 7-9 November 2012.

Jahanshad, N., Hibar, D., Ryles, A., Toga, A., McMahon, K., de Zubicaray, G., Hansel, N., Montgomery, G., Martin, N., Wright, M., Thompson, P. (2012). Discovery of genes that affect human brain connectivity: a genome-wide analysis of the connectome. In 9th International Symposium on Biomedical Imaging. 9th International Symposium on Biomedical Imaging, Barcelona, Spain, (542-545). 2-5 May 2012.

2012 Annual Report


Jahanshad, N., Kohannim, O., Toga, A., McMahon, K., de Zubicaray, G., Hansell, N., Montgomery, G., Martin, N., Wright, M., Thompson, P. (2012). Diffusion imaging protocol effects on genetic associations. In International Symposium on Biomedical Imaging. International Symposium on Biomedical Imaging, Barcelona, Spain. 2-5 May 2012.

Jahanshad, N., Prasad, A., McMahon, K., Martin, N., Wright, M., Thompson, P., de Zubicaray, G. (2012). Genetics of path lengths in brain connectivity networks: HARDI-based maps in 457 adults. In Pew-ThianYap, Tianming Liu, Dinggang Shen, Carl-Fredrik Westin, Li Shen (Eds.), Lecture Notes in Computer Science. Second International Multimodal Brain Image Analysis Workshop (MBIA 2012) in Conjunction with MICCAI 2012, Nice, France, (29-40). 1-5 October 2012.

Jeffery, C., Asad, A., Chan, S., Smith, S., Price, R., Harris, M., Mardon, K. (2012). Reliable production of the Pet isotope copper-64 using an Iba 18/9 cyclotron: target fabrication, purification and quality control for proof of conceptual Micro-Pet imaging. In Internal Medicine Journal. 42nd Annual Scientifi c Meeting of the Australian and New Zealand Society of Nuclear Medicine (ANZSNM), Melbourne VIC, Australia, (9-9). 28-30 April 2012.

Jin, J., Liu, F.Weber, E. & Crozier, S. (2012). Inverse field-based approach for the evaluation of electromagnetic fields and its application in local SNR-shimming for MRI. In 34BEMS: 34th Annual Conference of Bioelectromagnetics Society. 34BEMS: 34th Annual Conference of Bioelectromagnetics Society, Brisbane, Australia. 17 - 22 June 2012.

Jin, Y., Shi, Y., Zhan, L., Li, J., de Zubicaray, G., McMahon, K., Martin, N., Wright, M., Thompson, P. (2012). Automatic population HARDI white matter tract clustering by label fusion of multiple tract atlases. In Pew-Thian Yap, Tianming Liu, Dinggang Shen, Carl-Fredrik Westin, Li Shen (Eds.), Lecture Notes in Computer Science. Second International Multimodal Brain Image Analysis Workshop (MBIA 2012) in Conjunction with MICCAI 2012, Nice, France, (147-156). 1 - 5 October 2012.

Joshi, S., Joshi, A., Gutman, B., Toga, A., McMahon, K., de Zubicaray, G., Martin, N., Wright, M., Thompson, P. (2012). Genetic influences on sulcal patterns of the brain. In 9th International Symposium on Biomedical Imaging. 9th International Symposium on Biomedical Imaging, Barcelona, Spain, (414-417). 2 - 5 May 2012.

Kaminen-Ahola, N., Ahola, A., Maga, M., Zhang, C., Yamada, L., Kurniawan, N., Galloway, G., Cox, T., Whitelaw, E., Chong, S. (2012). Maternal ethanol consumption affects offspring epigenotype and phenotype in the mouse. In Alcoholism-Clinical and Experimental Research. 35th Annual Scientific Meeting of the Research Society on Alcoholism (RSA), San Francisco, CA, United States, (333A-333A). 23-27 June 2012.

Kharatishvili, I., She, D.Shan, Z. Kurniawan, N. & Reutens, D. (2012). Complement C3 Upregulation Contributes to a Sustained Inflammatory Response and Perpetuation of Seizure Foci in a Pilocarpine Model of Temporal Lobe Epilepsy. In 10th European Congress on Epileptology. 10th European Congress on Epileptology, London England, (3-3). Sep 30-Oct 04, 2012.

Klint, J., Anangi, R., Mobli, M., Knapp, O., Adams, D. & King, G. (2012). Spider-venom peptides that target the human NaV1.7 channel: Potential analgesics for the treatment of chronic pain. In Toxicon. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, (110-111). 8 - 13 July 2012.

Kurniawan, N., Yang, Z., Richards, K., Calamante, F., Ullmann, J., Galloway, G., Petrou, S., Reutens, DC. (2012). Visualization of mouse barrel cortex using ex-vivo track density imaging. In 20th Annual Meeting of the International Society for Magnetic Resonance in Medicine. 20th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Melbourne, VIC, Australia. 5-11 May 2012.

Li, M., Jin, J., Trakic, A., Liu, F., Weber, E., Li, Y., Crozier, S. (2012). High acceleration with a rotating radiofrequency coil array (RRFCA) in parallel magnetic resonance imaging (MRI). In IEEE Engineering in Medicine and Biology Society. Conference Proceedings. 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012, San Diego, United States, (1098-1101). 28 August - 1 September 2012.

Liu, F., Jin, J., Li, M., Trakic, A., Weber, E. & Crozier, S. (2012). On the reduction of transmit B1 non-uniformity and SAR using a single-loop rotating RF coil. In 34BEMS: 34th Annual Meeting of the Bioelectromagnetics Society. 34BEMS: 34th Annual Meeting of the Bioelectromagnetics Society, Brisbane, Australia. 17 - 22 June 2012.

Li, Y., Li, Bing K., Weber, E., Crozier, S., Schneider, J., Ullmann, P., Junge, S. (2012). Pre-clinical imaging at 9.4T using a versatile 8-channel Transceive Array. In: Proceedings of the International Society for Magnetic Resonance in Medicine, Melbourne, Australia, (). 5 - 11 May 2012.

Maddess, T., Ali, E., James, A., Voicu, C., Janke, A. & Lueck, C. (2012). The application of pupillary response to sparse multifocal stimuli in monitoring multiple sclerosis patients. In Neurology. 64th Annual Meeting of the American-Academy-of-Neurology (AAN), New Orleans, LA, United States, (P01.157.1-P01.157.2). 21-28 April 2012.

McClymont, D., Mehnert, A.Trakic, A. Kennedy, D. & Crozier, S. (2012). Segmentation of malignant lesions in breast MRI using distance-weighted three-variable co-occurrence. In Computer Assisted Radiology and Surgery. Computer Assisted Radiology and Surgery, Pisa, Italy. 27-30 June 2012.

Moldrich, R., Leanage, G. & Reutens, D. (2012). How sodium valproate causes language delay and autism - a molecular study. In Epilepsia. 10th European Congress on Epileptology, London England, (5-6). 30 September-4 October 2012.

Nguyen, P., Abbosh, A. & Crozier, S. (2012). Ultra-wideband balun using microstrip to slotline transitions. In 2012 IEEE Asia-Pacific Conference On Antennas and Propagation (Apcap). 2012 IEEE Asia-Pacific Conference on Antennas and Propagation, Singapore, (309-310). 27 - 29 August 2012.

Nguyen, P., Abbosh, A. & Crozier, S. (2012). Wideband quasi-Yagi antenna with tapered driver. In 2012 IEEE Asia-Pacific Conference On Antennas and Propagation (Apcap). 2012 IEEE Asia-Pacific Conference on Antennas and Propagation, Singapore, (138-139). 27 - 29 August 2012.

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Oborn, B., Metcalfe, P. Butson, M. Crozier, S. & Keall, P. (2012). Removal of electron contamination in longitudinal field MRI-Linac Systems: A Monte Carlo Study. In Medical Physics. 54th Annual Meeting and Exhibition of the American Association of Physicists in Medicine (AAPM), Charlotte, NC, United States, (3706-3706). 29 July-2 August 2012.

Oborn, B., Metcalfe, P. Crozier, S. Bailey, M. & Keall, P. (2012). EPID operation in a bi-directional MRI-Linac System: A Monte Carlo Study. In Medical Physics. 54th Annual Meeting and Exhibition of the American Association of Physicists in Medicine (AAPM), Charlotte, NC, United States, (3889-3889). 29 July-2 August 2012.

Roberts, M., Teng, L., Buck, M., Schirra, H., Hancock, J., Clarke, R., Samaratunga, H., Zenzmaier, C., Lavin, M. and Gardiner, R. (2012). Molecular and metabonomic ejaculate profiling enables prostate cancer detection. In Abstracts of the Urological Society of Australia and New Zealand 65th Annual Scientific Meeting. 65th Annual Scientific Meeting on Urological Society of Australia and New Zealand, Darwin, NT, Australia, (8-8). 21-24 April 2012.

Rowe, C., Ellis, K., Brown, B., Bourgeat, P., Jones, G., Salvado, O., Martins, R., Masters, CL., Ames, D., Villemagne, VL. (2012). Imaging and Cognitive Biomarkers as Predictors of Progression to Alzheimer'S Disease. In Internal Medicine Journal. 42, (13-13). .

Scheck, S., Pannek, K. Boyd, R. & Rose, S. (2012). Morphology and connectivity of the anterior cingulate cortex in unilateral cerebral palsy. In Australasian Cognitive Neuroscience Conference. Australasian Cognitive Neuroscience Conference, Brisbane Australia. 29 November-2 December 2012.

Shen, K., Bourgeat, P. Fripp, J. Meriaudeau, F. & Salvado, O. (2012). Consistent estimation of shape parameters in statistical shape model by symmetric EM algorithm. In Conference on Medical Imaging - Image Processing. Conference on Medical Imaging - Image Processing, San Diego Ca. Feb 06-09, 2012.

Tieng, Q., Vegh, V., Brereton, I., Reutens, D. & Yang, Z. (2012). The use of inverse phase Fourier image to accommodate intensity inhomogeneities in medical image registration. In 2012 Fourth International Conference on Computational Intelligence, Modelling and Simulation (CIMSiM). 2012 Fourth International Conference on Computational Intelligence, Modelling and Simulation (CIMSiM), Kuantan, Malaysia, (276-281). 25 - 27 September 2012.

Tieng, Q., Vegh, V.Reutens, D. & Yang, Z. (2012). Application of Weber's law to medical image registration to accommodate intensity inhomogeneities. In 2012 International Conference On Digital Image Computing Techniques and Applications (Dicta). 2012 International Conference on Digital Image Computing Techniques and Applications (DICTA), Fremantle, Australia, (1-7). 3-5 December 2012.

Ullmann, J. F. P., Janke, A. L., Watson, C., Kurniawan, N. D., Paxinos, G., Keller, M, Yang, Z., Richards, K., Egan, G., Petrou, S., Galloway, G. and Reutens, D. (2012). Probabilistic atlas of the C57BL/6J mouse cerebellum. In ISMRM 20th Annual Meeting & Exhibition: Adapting MR in a Changing World. 20th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Melbourne, VIC, Australia, 5-11 May 2012.

Vegh, V., Ariens, M.Ullmann, J. Kurniawan, N. & Reutens, D. (2012). Structural magnetic resonance imaging of zebrafish brain using dedicated radio frequency microcoils. In 20th Annual Meeting of the International Society for Magnetic Resonance in Medicine. 20th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Melbourne, VIC, Australia. 5-11 May 2012.

Whelan, B., Kumar, S., Dowling, J., Lambert, J., Lim, K., Salvado, O., Begg, J., Greer, P., Vinod, S. and Holloway, L. (2012). Requirements for the Accuracy of Electron Density Data Planning for MRI Based Cervix Cancer Treatment Planning. In Medical Physics. 54th Annual Meeting and Exhibition of the American-Association-of-Physicists-in-Medicine (AAPM), Charlotte Nc, (3694-3694). Jul 29-Aug 02, 2012.

Widiapradja, A., Vegh, V.Lok, K. Cheng, Y. & Arumugam, T. (2012). Intravenous immunoglobulin (IVIg) protects neurons against ischaemic stroke by attenuating multiple cell death pathways. In International Journal of Stroke. Stroke 2012 Conference - A combined event of the Stroke Society of Australasia 2012 Annual Scientific Meeting and the 8th Smart Strokes Australasian Nursing and Allied Health Stroke Conference, Sydney NSW Australia, (19-19). 29-31 August 2012.

Yang, Z., Crozier, S., Engstrom, C., Schwarz, R., Lauer, L., Fripp, J., Chandra, S., Xia, Y., Neubert, A., Salvado, O., Brancato, T. (2012). Morphology-based interslice interpolation on manual segmentations of joint bones and muscles in MRI. In 2012 International Conference on Digital Image Computing Techniques and Applications (DICTA). 2012 International Conference on Digital Image Computing Techniques and Applications (DICTA), Fremantle, WA, Australia, (). 3-5 December 2012.

Yang, Z., Vegh, V. & Reutens, D. (2012). A fast multi-resolution differential evolution method for multimodal image registration. In 2012 5th International Congress on Image and Signal Processing (CISP 2012). 2012 5th International Congress on Image and Signal Processing (CISP 2012), Chongqing, Sichuan, China, (804-809). 16 - 18 October 2012.

Yates, P., Desmond, P., Raniga, P., Phal, P., Steward, C., Ellis, K., Salvado, O., Masters, C. L., Villemagne, V. L. and Rowe, C. C. (2012). Incidence and Associations of Lobar Microbleeds: Results From the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (Aibl). In Internal Medicine Journal. 42, (33-33).

Zhang, C., Yamada, L., Ho, M. F., Kaminen-Ahola, N., Ahola, A., Maga, M., Kurniawan, N., Galloway, G., Cox, T., Whitelaw, E. and Chong, S. (2012). Maternal Ethanol Consumption Affects Offspring Epigenotype and Phenotype in the Mouse. In: Alcoholism-Clinical and Experimental Research. 16th World Congress of the International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA), Sapporo Japan, (56A-56A). Sep 09-12, 2012

Journal Article

Acosta, Oscar, Fripp, Jurgen, Dore, Vincent, Bourgeat, Pierrick, Favreau, Jean-Marie, Chetelat, Gaël, Rueda, Andrea, Villemagne, Victor L., Szoeke, Cassandra, Ames, David, Ellis, Kathryn A., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Bonner, Erik, Gris, Florence, Xiao, Di, Raniga, Parnesh, Barra, Vincent and Salvado, Olivier (2012) Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer's disease. Journal of Neuroscience Methods, 205 1: 96-109

2012 Annual Report


Anangi, R., Rash, L., Mobli, M. & King, G. (2012) Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3. Marine Drugs, 10 7: 1605-1618.

Arciuli, J., McMahon, K. & de Zubicaray, G. (2012) Probabilistic orthographic cues to grammatical category in the brain. Brain and language, 123 3: 202-210.

Auger, D., Bleeker, G., Bertini, M., Ewe, S., Van Bommel, R., Witkowski, T. Ng AC, van Erven L, Schalij MJ, Bax JJ, Delgado V. (2012) Effect of cardiac resynchronization therapy in patients without left intraventricular dyssynchrony. European Heart Journal, 33 7: 913-920.

Babourina-Brooks, B., Cowin, G. & Wang, D. (2012) Diffusion-weighted imaging in the prostate: An apparent diffusion coefficient comparison of half-Fourier acquisition single-shot turbo spin-echo and echo planar imaging. Magnetic Resonance Imaging, 30 2: 189-194.

Bertini, Matteo, Höke, Ulas, van Bommel, Rutger J., Ng, Arnold C. T., Shanks, Miriam, Nucifora, Gaetano, Auger, Dominique, Borleffs, Jan C. Willem, van Rijnsoever, Eva P., van Erven, Lieselot, Schalij, Martin J., Marsan, Nina A., Bax, Jeroen J. and Delgado, Victoria (2012) Impact of clinical and echocardiographic response to cardiac resynchronization therapy on long-term survival. European Heart Journal Cardiovascular Imaging, Epub 2012 Dec 7.

Bertini, Matteo, Ng, Arnold C. T., Antoni, M. Louisa, Nucifora, Gaetano, Ewe, See H., Auger, Dominique, Marsan, Nina Ajmone, Schalij, Martin J., Bax, Jeroen J. and Delgado, Victoria (2012) Global longitudinal strain predicts long-term survival in patients with chronic ischemic cardiomyopathy. Circulation: Cardiovascular Imaging, 5 3: 383-391.

Blakey, I., Merican, Z., Rintoul, L., Chuang, Y., Jack, K. & Micallef, A. (2012) Interactions of iodoperfluorobenzene compounds with gold nanoparticles. Physical Chemistry Chemical Physics, 14 10: 3604-3611.

Blokland, G., de Zubicaray, G., McMahon, K. & Wright, M. (2012) Genetic and environmental influences on neuroimaging phenotypes: A meta-analytical perspective on twin imaging studies. Twin Research and Human Genetics, 15 3: 351-371.

Boase, N., Blakey, I. & Thurecht, K. (2012) Molecular imaging with polymers. Polymer Chemistry, 3 6: 1384-1389.

Bourne, R.M., Kurniawan, N., Cowin, G., Stait-Gardner, T., Sved, P., Watson, G., Chowdhury, S., Price, W.S. (2012) Biexponential diffusion decay in formalin-fixed prostate tissue: Preliminary findings. Magnetic Resonance In Medicine, 68 3: 954-959.

Bourne, R.M., Kurniawan, N., Cowin, G., Stait-Gardner, T., Sved, P., Watson, G., Price, W.S. (2012) Microscopic diffusivity compartmentation in formalin-fixed prostate tissue. Magnetic Resonance in Medicine, 68 2: 614-620.

Bourne, R., Kurniawan, N., Cowin, G. Sved, P. & Watson, G. (2012) Microscopic diffusion anisotropy in formalin fixed prostate tissue: Preliminary findings. Magnetic Resonance in Medicine, 68 6: 1943-1948.

Bradfield, N., Reutens, D., Chen, J. & Wood, A. (2012) Stereotaxic localisation of the dorsolateral prefrontal cortex for transcranial magnetic stimulation is superior to the standard reference position. Australian and New Zealand Journal of Psychiatry, 46(3): 232-239.

Braskie, M.N., Jahanshad, N., Stein, J.L., Barysheva, M., Johnson, K., McMahon, K.L., de Zubicaray, G.I., Martin, N.G., Wright, M.J., Ringman, J.M., Toga, A.W., Thompson, P.M. (2012) Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults. The Journal of Neuroscience, 32 17: 5964-5972.

Braskie, M.N., Jahanshad, N., Toga, A.W., McMahon, K.L, de Zubicaray, G.I., Martin, N.G., Wright, M.J., Thompson, P.M. (2012) How a common variant in the growth factor receptor gene, NTRK1, affects white matter. BioArchitecture, 2 5: 1-4.

Calamante, F., Tournier, J.D., Kurniawan, N.D., Yang, Z., Gyengesi, E., Galloway, G.J., Reutens, D.C., Connelly, A. (2012) Super-resolution track-density imaging studies of mouse brain: Comparison to histology. NeuroImage, 59 1: 286-296.

Camp, D., Campitelli, M.Hanson, G. & Jenkins, I. (2012) Formation of an unusual four-membered nitrogen ring (Tetrazetidine) radical cation. Journal of the American Chemical Society, 134 39: 16188-16196.

Cawley, P.J., Hamilton-Craig, C., Owens, D.S., Krieger, E.V., Strugnell, W.E., Mitsumori, L., D’Jang, C.L., Schwaegler, R.G., Nguyen, K.Q., Nguyen, B., Maki, J.H., Otto, C.M. (2013) Prospective comparison of valve regurgitation quantitation by cardiac magnetic resonance imaging and transthoracic echocardiography. Circulation: Cardiovascular Imaging, 6 1: 48-57

Challinor, V.L., Stuthe, J.M.U., Parsons, P.G., Lambert, L.K., Lehmann, R.P., Kitching, W., De Voss, J. J. (2012) Structure and bioactivity of steroidal saponins isolated from the roots of Chamaelirium luteum (False Unicorn). Journal of Natural Products, 75 8: 1469-1479

2012 Annual Report


Chandler-Temple, A., Kingshott, P.Wentrup-Byrne, E. Cassady, A. & Grondahl, L. (2012) Surface chemistry of grafted expanded poly(tetrafluoroethylene) membranes modifies the in vitro proinflammatory response in macrophages. Journal of Biomedical Materials Research - Part A. Epub 2012 Sep 11.

Chandra, Shekhar S., Dowling, Jason A., Shen, Kai-Kai, Raniga, Parnesh, Pluim, Josien P. W., Greer, Peter B., Salvado, Olivier and Fripp, Jurgen (2012) Patient specific prostate segmentation in 3-D magnetic resonance images. IEEE Transactions On Medical Imaging, 31 10: 1955-1964.

Cheng, Han-Hao, Yu, Anguang, Keen, Imelda, Chuang, Yami, Jack, Kevin S., Leeson, Michael J., Younkin, Todd R., Blakey, Idriss and Whittaker, Andrew K. (2012) Electron-beam induced freezing of an aromatic based EUV resist: a robust template for directed self assembly of block copolymers. IEEE Transactions on Nanotechnology, 11 6: 1140-1147

Cheng, Mario, Marinovic, Welber, Watson, Marcus, Ourselin, Sebastien, Passenger, Josh, De Visser, Hans, Salvado, Olivier and Riek, Stephan (2012) Abdominal palpation haptic device for colonoscopy simulation using pneumatic control. IEEE Transactions on Haptics, 5 2: 97-108.

Chen, Lan, Goh, Yong Keng, Cheng, Han Hao, Smith, Bruce W., Xie, Peng, Montgomery, Warren, Whittaker, Andrew K. and Blakey, Idriss (2012) Aqueous developable dual switching photoresists for nanolithography. Journal of Polymer Science Part A: Polymer Chemistry, 50 20: 4255-4265.

Chen, M., H.Zhou, J. Bartlett, P. & Xu, Z. (2013) Reduction in the size of layered double hydroxide nanoparticles enhances the efficiency of siRNA delivery. Journal of Colloid and Interface Science, 390 1: 275-281.

Chiang, M., Barysheva, M., McMahon, K., de Zubicaray, G., Johnson, K., Montgomery, G., Martin, N., Toga, A., Wright, M., Shapshak, P., Thompson, P.M. (2012) Gene network effects on brain microstructure and intellectual performance identified in 472 twins. Journal of Neuroscience, 32 25: 8732-8745.

Chuang, Y., Jack, K.Cheng, H. Whittaker, A. & Blakey, I. (2012) Using directed self assembly of block copolymer nanostructures to modulate nanoscale surface roughness: towards a novel lithographic process. Advanced Functional Materials, 23 2: 173-183.

Chung, D., Whittaker, A. & Choi, S. (2012) Electrochemical DNA biosensor based on IL-modified MWNTs electrode prepared by radiation-induced graft polymerization. Journal of Applied Polymer Science, 126 s2: E28-E33.

Comba, Peter, Dovalil, Nina, Gahan, Lawrence R., Haberhauer, Gebhard, Hanson, Graeme R., Noble, Christopher J., Seibold, Björn and Vadivelu, Prabha (2012) CuII coordination chemistry of patellamide derivatives: Possible biological functions of cyclic pseudo-peptides. Chemistry: A European Journal, 18 9: 2578-2590.

Comba, Peter, Gahan, Lawrence R., Hanson, Graeme R., Mereacre, Valeriu, Noble, Christopher J., Powell, Annie K., Prisecaru, Ion, Schenk, Gerhard and Zajaczkowski-Fischer, Marta (2012) Monoesterase activity of a purple acid phosphatase mimic with a cyclam platform. Chemistry: A European Journal, 18 6: 1700-1710.

Comba, P., Gahan, L., Hanson, G. & Westphal, M. (2012) Phosphatase reactivity by a dicopper(II) complex of a patellamide derivative - possible biological functions of cyclic pseudopeptides. Chemical Communications, 48(75): 9364-9366.

Comba, Peter, Gahan, Lawrence R., Mereacre, Valeriu, Hanson, Graeme R., Powell, Annie K., Schenk, Gerhard and Zajaczkowski-Fischer, Marta (2012) Spectroscopic characterization of the active (FeFeIII)-Fe-III and (FeFeII)-Fe-III forms of a purple acid phosphatase model system. Inorganic Chemistry, 51 22: 12195-12209.

Cummins, T.D.R., Hawi, Z, Hocking, J, Strudwick, M, Hester, R., Garavan, H., Wagner, J., Chambers, C.D., Bellgrove M.A. (2012) Dopamine transporter genotype predicts behavioural and neural measures of response inhibition. Molecular Psychiatry, 17(11): 1086-1092.

Cyarto, Elizabeth V., Lautenschlager, Nicola T., Desmond, Patricia M., Ames, David, Szoeke, Cassandra, Salvado, Olivier, Sharman, Matthew J., Ellis, Kathryn A., Phal, Pramit M., Masters, Colin L., Rowe, Christopher C., Martins, Ralph N. and Cox, Kay L. (2012) Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial. BMC Psychiatry, 12: 167.1-167.11.

Danaher, L. & Steinke, K. (2013) Hot tips on hot tips: technical problems with percutaneous insertion of a microwave antenna through rigid tissue. Journal of Medical Imaging and Radiation Oncology, 57 1: 57-60.

Dantas de Araujo, A., Mobli, M., King, G. & Alewood, P. (2012) Cyclization of peptides by using selenolanthionine bridges. Angewandte Chemie International Edition, 51 41: 10298-10302.

Delgado, V. & Ng, C. (2012) Assessment of left ventricular systolic function in aortic stenosis and prognostic implications. European Heart Journal Cardiovascular Imaging, 13 10: 805-807.

2012 Annual Report


Dennis, Emily L., Jahanshad, Neda, McMahon, Katie L., de Zubicaray, Greig I., Martin, Nicholas G., Hickie, Ian B., Toga, Arthur W., Wright, Margaret J. and Thompson, Paul M. (2012) Development of brain structural connectivity between ages 12 and 30: a 4-tesla diffusion imaging study in 439 adolescents and adults. NeuroImage, 64 : 671-684

Dennis, Emily L., Jahanshad, Neda, Rudie, Jeffrey D., Brown, Jesse A., Johnson, Kori, McMahon, Katie L., de Zubicaray, Greig I., Montgomery, Grant, Martin, Nicholas G., Wright, Margaret J., Bookheimer, Susan Y., Dapretto, Mirella, Toga, Arthur W. and Thompson, Paul M. (2012) Altered structural brain connectivity in healthy carriers of the autism risk gene, CNTNAP2. Brain Connectivity, 1 6: 447-460

Dey, P., Blakey, I.Thurecht, K. & Fredericks, P. (2013) Self-assembled hyperbranched polymer-gold nanoparticle hybrids: understanding the effect of polymer coverage on assembly size and SERS performance. Langmuir, 29 2: 525-533.

de Zubicaray, G., Hansen, S. & McMahon, K. (2013) Differential processing of thematic and categorical conceptual relations in spoken word production. Journal of Experimental Psychology: General, 142 1: 131-142.

de Zubicaray, G., Miozzo, M.Johnson, K. Schiller, N. & McMahon, K. (2012) Independent distractor frequency and age-of-acquisition effects in picture-word interference: fMRI evidence for post-lexical and lexical accounts according to distractor type. Journal of Cognitive Neuroscience, 24 2: 482-495.

Diaz, Marianne, Martel, Nick, Fitzsimmons, Rebecca L., Eriksson, Natalie A., Cowin, Gary J., Thomas, Gethin P., Lê Cao, Kim-Anh, Muscat, George E. O. and Leong, Gary M. (2012) Ski overexpression in skeletal muscle modulates genetic programs that control susceptibility to diet-induced obesity and insulin signaling. Obesity, 20 11: 2157-2167

Dou, Jianhong, Xia, Ling, Deng, Dongdong, Zang, Yunliang, Shou, Guofa, Bustos, Cesar, Tu, Weifeng, Liu, Feng and Crozier, Stuart (2012) A study of mechanical optimization strategy for cardiac resynchronization therapy based on an electromechanical model. Computational and Mathematical Methods in Medicine, 2012 : 948781.1-948781.13

Dowling, Jason A., Lambert, Jonathan, Parker, Joel, Salvado, Olivier, Fripp, Jurgen, Capp, Anne, Wratten, Chris, Denham, James W. and Greer, Peter B. (2012) An atlas-based electron density mapping method for magnetic resonance imaging (MRI)-alone treatment planning and adaptive MRI-based prostate radiation therapy. International Journal of Radiation: Oncology - Biology - Physics, 83 1: E5-E11.

Duarte-Carvajalino, Julio M., Jahanshad, Neda, Lenglet, Christophe, McMahon, Katie L., de Zubicaray, Greig I., Martin, Nicholas G., Wright, Margaret J., Thompson, Paul M. and Sapiro, Guillermo (2012) Hierarchical topological network analysis of anatomical human brain connectivity and differences related to sex and kinship. NeuroImage, 59 4: 3784-3804

Du, J., Vegh, V. & Reutens, D. (2012) The laminar cortex model: a new continuum cortex model incorporating laminar architecture. PLoS Computational Biology, 8 10: e1002733.1-e1002733.9.

Dulhunty, J., Suhrbier, A., Macaulay, G., Brett, J., van Straaten, A., Brereton, I., Farmer, G.F. (2012) Guide-wire fragment embolisation in paediatric peripherally inserted central catheters. Medical Journal of Australia, 196 4: 250-255.

Dunster, K., Friese, M. Fraser, J. Cowin, G. & Schibler, A. (2012) Ventilation distribution in rats: Part I - The effect of gas composition as measured with electrical impedance tomography. BioMedical Engineering Online, 11 4: 64.1-64.9.

Dunster, K., Friese, M., Fraser, J., Galloway, G., Cowin, G. & Schibler, A. (2012) Ventilation distribution in rats: Part 2-A comparison of electrical impedance tomography and hyperpolarised helium magnetic resonance imaging. BioMedical Engineering Online, 11: 68-1-68-10.

Elliott, J., Pedler, A. Cowin, G. Sterling, M. & McMahon, K. (2012) Spinal cord metabolism and muscle water diffusion in whiplash. Spinal Cord, 50 6: 474-476.

Elma, M., Yacou, C.Wang, D. Smart, S. & da Costa, J. (2012) Microporous silica based membranes for desalination. Water, 4 3: 629-649.

Evans, A., Janke, A., Collins, D. & Baillet, S. (2012) Brain templates and atlases. NeuroImage, 62 2: 911-922.

Gripari, Paola, Ewe, See Hooi, Fusini, Laura, Muratori, Manuela, Ng, Arnold C. T., Cefalu, Claudia, Delgado, Victoria, Schalij, Martin J., Bax, Jeroen J., Marsan, Nina Ajmone, Tamborini, Gloria and Pepi, Mauro (2012) Intraoperative 2D and 3D transoesophageal echocardiographic predictors of aortic regurgitation after transcatheter aortic valve implantation. Heart, 98 16: 1229-1236.

Hamilton-Craig, C., Friedman, D. & Achenbach, S. (2012) Cardiac computed tomography-evidence, limitations and clinical application. Heart, Lung and Circulation, 21 2: 70-81.

2012 Annual Report


Hamilton-Craig, C., Friedman, D. & Achenbach, S. (2012) Response to Parsonage et al.: Reply to "The role of cardiac computed tomography in assessment of acute chest pain". Heart Lung and Circulation, 21(11): 763-764.

Hamilton-Craig, C., Raffel, O., Pincus, M., Hansen, M., Slaughter, R. & Walters, D. (2012) Coronary CT angiography for patients with stable chest pain in the Emergency Department; an appraisal of current and emerging evidence. Internal Medicine Journal, 42(2): 226-228.

Hamilton-Craig, C., Strugnell, W., Raffel, O., Porto, I., Walters, D. & Slaughter, R. (2012) CT angiography with cardiac MRI: Non-invasive functional and anatomical assessment for the etiology in newly diagnosed heart failure. International Journal of Cardiovascular Imaging, 28(5): 1111-1122.

Haque, E., Whittaker, A., Gidley, M., Deeth, H., Fibrianto, K. & Bhandari, B. (2012) Kinetics of enthalpy relaxation of milk protein concentrate powder upon ageing and its effect on solubility. Food Chemistry, 134(3): 1368-1373.

Harms, L., Cowin, G., Eyles, D., Kurniawan, N., McGrath, J. & Burne, T. (2012) Neuroanatomy and psychomimetic-induced locomotion in C57BL/6J and 129/X1SvJ mice exposed to developmental vitamin D deficiency. Behavioural Brain Research, 230(1): 125-131.

Harrison, J., Bartlett, C., Cowin, G., Nicholls, P., Evans, C., Clemons, T., Zdyrko, B., Luzinov, I., Harvey, A., Iyer, K., Dunlop, S., Fitzgerald, M. (2012) In vivo imaging and biodistribution of multimodal polymeric nanoparticles delivered to the optic nerve. Small, 8(10): 1579-1589.

Harrison, M., O'Brien, A., Adams, L., Cowin, G., Ruitenberg, M., Sengul, G., Watson, C. (2013) Vertebral landmarks for the identification of spinal cord segments in the mouse. NeuroImage, 68: 22-29.

Heath, S., McMahon, K., Nickels, L., Angwin, A., MacDonald, A., van Hees, S., Johnson, K., McKinnon, E., Copland, D. (2012) Neural mechanisms underlying the facilitation of naming in aphasia using a semantic task: an fMRI study. BMC Neuroscience, 13(98): 98.1-98.19.

Heath, S., McMahon, K., Nickels, L., Angwin, A., MacDonald, A., van Hees, S., Johnson, K., Copland, D. (2012) Priming picture naming with a semantic task: An fMRI investigation. PLoS One, 7(3): e32809.1-e32809.9.

Heath, S., McMahon, K., Nickels, L., Angwin, A., MacDonald, A., van Hees, S., Johnson, K., Copland, D. (2012) The neural correlates of picture naming facilitated by auditory repetition. BMC Neuroscience, 13(1): 21.1-21.13.

Hester, R., Nandam, L., O'Connell, R., Wagner, J., Strudwick, M., Nathan, P., Mattingley, J., Bellgrove, M. (2012) Neurochemical enhancement of conscious error awareness. Journal of Neuroscience, 32(8): 2619-2627.

Hibar, Derrek P., Jahanshad, Neda, Stein, Jason L., Kohannim, Omid, Toga, Arthur W., Medland, Sarah E., Hansell, Narelle K., McMahon, Katie L., de Zubicaray, Greig I., Montgomery, Grant W., Martin, Nicholas G., Wright, Margaret J. and Thompson, Paul M. (2012) Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins. Twin Research and Human Genetics, 15 3: 286-295.

Hibar, Derrek P., Stein, Jason L., Ryles, April B., Kohannim, Omid, Jahanshad, Neda, Medland, Sarah E., Hansell, Narelle K., McMahon, Katie L., de Zubicaray, Greig I., Montgomery, Grant W., Martin, Nicholas G., Wright, Margaret J., Saykin, Andrew J., Jack, lifford R., Weiner, Michael W., Toga, Arthur W. and Thompson, Paul M. (2012) Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects. Brain Imaging and Behavior, In Press.

Hochrein, J., Klein, M., Zacharias, H., Li, J., Wijffels, G., Schirra, H., Spang, R., Oefner, P., Gronwald, W. (2012) Performance evaluation of algorithms for the classification of metabolic 1H-NMR fingerprints. Journal of Proteome Research, 11(12): 6242-6251.

Jahanshad, N., Kohannim, O., Hibar, D., Stein, J., McMahon, K., de Zubicaray, G., Medland, S., Montgomery, G., Whitfield, B., Martin, N., Wright, M., Toga, A., Thompson, P. (2012) Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene. Proceedings of the National Academy of Sciences of USA, 109(14): E851-E859.

Jennings, James, Beija, Mariana, Richez, Alexandre P., Cooper, Samuel D., Mignot, Paul E., Thurecht, Kristofer J., Jack, Kevin S. and Howdle, Steven M. (2012) One-pot synthesis of block copolymers in supercritical carbon dioxide: A simple versatile route to nanostructured microparticles. Journal of the American Chemical Society, 134 10: 4772-4781

Jensen, J., Mobli, M., Brust, A., Alewood, P., King, G. & Rash, L. (2012) Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3. Marine Drugs, 10(7): 1511-1527.

Jin, J., Liu, F.Weber, E. & Crozier, S. (2012) Improving SAR estimations in MRI using subject-specific models. Physics in Medicine and Biology, 57(24): 8153-8171.

2012 Annual Report


Jin, Jin, Liu, Feng, Zuo, Zhentao, Xue, Rong, Li, Mingyan, Li, Yu, Weber, Ewald and Crozier, Stuart (2012) Inverse field-based approach for simultaneous B-1 mapping at high fields: A phantom based study. Journal of Magnetic Resonance, 217: 27-35.

Keen, Imelda, Anguang Yu, Cheng, Han-Hao, Jack, Kevin S., Nicholson, Timothy, Whittaker, Andrew K. and Blakey, Idriss (2012) Control of the orientation of symmetric poly(styrene)-block-poly(D,L-lactide) block copolymers using statistical copolymers of dissimilar composition. Langmuir, 28 45: 15876-15888

Kerbler, Georg M., Hamlin, Adam S., Pannek, Kerstin, Kurniawan, Nyoman D., Keller, Marianne D., Rose, Stephen E. and Coulson, Elizabeth J. (2012) Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model. NeuroImage, 2 66C: 133-141.

King, Gordon J., Chanson, Aurelie H., McCallum, Emily J., Ohme-Takagi, Masaru, Byriel, Karl, Hill, Justine M., Martin, Jennifer L. and Mylne, Joshua S. (2013) The Arabidopsis B3 domain protein VERNALIZATION1 is involved in processes essential for development with structural and mutational studies revealing its DNA binding surface. Journal of Biological Chemistry, 288 5: 3198-3207

Knapp, O., Nevin, S., Yasuda, T., Lawrence, N., Lewis, R. & Adams, D. (2012) Biophysical properties of Nav 1.8/Nav 1.2 chimeras and inhibition by µO-conotoxin MrVIB. British Journal of Pharmacology, 166(7): 2148-2160.

Kohannim, Omid, Hibar, Derrek P., Stein, Jason L., Jahanshad, Neda, Hua, Xue, Rajagopalan, Priya, Toga, Arthur W., Jack Jr., Clifford R., Weiner, Michael W., de Zubicaray, Greig I., McMahon, Katie L., Hansell, Narelle K., Martin, Nicholas G., Margaret J. Wright, Thompson, Paul M. and The Alzheimer’s Disease Neuroimaging Initiative (2012) Discovery and replication of gene influences on brain structure using LASSO regression. Frontiers in Neuroscience, 6: 115.1-115.13.

Kohannim, O., Jahanshad, N., Braskie, M., Stein, J., Chiang, M., Reese, AH., Hibar, DP., Toga, AW., McMahon, KL., de Zubicaray, GI., Medland, SE., Montgomery, GW., Martin, NG., Wright, MJ., Thompson, PM. (2012) Predicting white matter integrity from multiple common genetic variants. Neuropsychopharmacology, 37(9): 2012-2019.

Li, B., Wang, H., Trakic, A., Engstrom, C., Weber, E. & Crozier, S. (2012) An orthogonal-based decoupling method for MRI phased array coil design. NMR in Biomedicine, 25(6): 835-842.

Li, J., Schirra, H., Yu, Y., Colgrave, M., Stoermer, M. & Wijffels, G. (2012) Identification of crotonyl glycine in urine of sheep after 48h road transport. Journal of Pharmaceutical and Biomedical Analysis, 67–68: 129-136.

Lin, X., Ding, K., Liu, Y., Yan, X., Song, S. & Jiang, T. (2012) Altered spontaneous activity in anisometropic amblyopia subjects: revealed by resting-state fMRI. PLoS One, 7(8): e43373.1-e43373.8.

Liu, Fan, van der Lijn, Fedde, Schurmann, Claudia, Zhu, Gu, Chakravarty, M. Mallar, Hysi, Pirro G., Wollstein, Andreas, Lao, Oscar, de Bruijne, Marleen, Ikram, M. Arfan, van der Lugt, Aad, Rivadeneira, Fernando, Uitterlinden, Andre G., Hofman, Albert, Niessen, Wiro J., Homuth, Georg, de Zubicaray, Greig, McMahon, Katie L., Thompson, Paul M., Daboul, Amro, Puls, Ralf, Hegenscheid, Katrin, Bevan, Liisa, Pausova, Zdenka, Medland, Sarah E., Montgomery, Grant W., Wright, Margaret J., Wicking, Carol A., Boehringer, Stefan, Spector, Timothy D., Paus, Tomas, Martin, Nicholas G., Biffar, Reiner and Kayser, Manfred for the International Visible Trait Genetics (VisiGen) Consortium (2012) A Genome-Wide Association Study Identifies Five Loci Influencing Facial Morphology in Europeans. PLoS Genetics, 8 9 Article No. e1002932:

Liu, Hailong, Kaneko, Yoshio, Ouyang, Xuan, Li, Li, Hao, Yihui, Chen, Eric Y. H., Tianzi, Jiang, Zhou, Yuan and Liu, Zhening (2012) Schizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network. Schizophrenia Bulletin, 38 2: 285-294.

Liu, Jian, Yang, Heng Quan, Kleitz, Freddy, Chen, Zhi Gang, Yang, Tianyu, Strounina, Ekaterina, Lu, Gao Qing (Max) and Qiao, Shi Zhang (2012) Yolk-shell hybrid materials with a periodic mesoporous organosilica shell: Ideal nanoreactors for selective alcohol oxidation. Advanced Functional Materials, 22 3: 591-599

Liu, L., Sanchez-Lopez, H., Liu, F. & Crozier, S. (2013) Flanged-edge transverse gradient coil design for a hybrid LINAC-MRI system. Journal of Magnetic Resonance, 226: 70-78.

Liu, L., Sanchez-Lopez, H.Poole, M. Liu, F. & Crozier, S. (2012) Simulation and analysis of the interactions between split gradient coils and a split magnet cryostat in an MRI-PET system. Journal of Magnetic Resonance, 222: 8-15.

Li, Yonghui, Liu, Bing, Hou, Bing, Qin, Wen, Wang, Dawei, Yu, Chunshui and Jiang, Tianzi (2012) Less efficient information transfer in Cys-allele carriers of DISC1: a brain network study based on diffusion MRI. Cerebral Cortex, Epub 2012 Jun 12.

Maillet, D., Ruehle, A., Reutens, D. & Vegh, V. (2012) An adaptable MRI radiofrequency breast coil: Evaluation of size, coil diameter, and uniformity. Concepts in Magnetic Resonance Part B: Magnetic Resonance Engineering, 41B (2): 50-56.

2012 Annual Report


Maller, JJ, Thomson, RH, Pannek, K, Rose, SE, Bailey, N, Lewis, PM and Fitzgerald, PB. 2012. The (Eigen) value of diffusion tensor imaging to investigate depression after traumatic brain injury. Hum. Brain Mapp. Epub 2012 Sep 24.

Mas, C., Chen, K. Brereton, I. Martin, J. & Hill, J. (2012) Backbone resonance assignments of the monomeric DUF59 domain of human Fam96a. Biomolecular NMR Assignments.

McPherson, B., McMahon, K. Wilson, W. & Copland, D. (2012) “I know you can hear me”: Neural correlates of feigned hearing. Human Brain Mapping, 33(8): 1964-1972.

Mobli, M., Maciejewski, M.Schuyler, A. Stern, A. & Hoch, J. (2012) Sparse sampling methods in multidimensional NMR. Physical Chemistry Chemical Physics, 14(31): 10835-10843.

Morrow, Carl A., Lee, I. Russell, Chow, Eve W. L., Ormerod, Kate L., Goldinger, Anita, Byrnes III, Edmond J., Nielsen, Kirsten, Heitman, Joseph, Schirra, Horst Joachim and Fraser, James A. (2012) A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. mBio, 3 2: e00310.1-e00310.11.

Morrow, Carl A., Valkov, Eugene, Stamp, Anna, Chow, Eve W. L., Lee, I. Russel, Wronski, Ania, Williams, Simon J., Hill, Justine M., Djordjevic, Julianne T., Kappler, Ulrke, Kobe, Bostjan and Fraser, James A. (2012) De novo GTP biosynthesis is critical for virulence of the fungal pathogen cryptococcus neoformans. PLoS Pathogens, 8 10.

Mostert, Albertus B., Powell, Benjamin J., Pratt, Francis L., Hanson, Graeme R., Sarna, Tadeusz, Gentle, Ian R. and Meredith, Paul (2012) Role of semiconductivity and ion transport in the electrical conduction of melanin. Proceedings of the National Academy of Sciences of USA, 109 23: 8943-8947.

Mourer, Jacqueline S., Ewe, See Hooi, Mallat, Marko J. K., Ng, Arnold C. T., Rabelink, Ton J., Bax, Jeroen J., Delgado, Victoria and de Fijter, Johan W. (2012) Late Calcineurin Inhibitor Withdrawal Prevents Progressive Left Ventricular Diastolic Dysfunction in Renal Transplant Recipients. Transplantation, 94 7: 721-728.

Munnemann, K., Kolzer, M. Blakey, I. Whittaker, A. & Thurecht, K. (2012) Hyperbranched polymers for molecular imaging: Designing polymers for parahydrogen induced polarisation (PHIP). Chemical Communications, 48(10): 1583-1585.

Mylne, J., Mas, C. & Hill, J. (2012) NMR assignment and secondary structure of the C-terminal DNA binding domain of Arabidopsis thaliana VERNALIZATION1. Biomolecular NMR Assignments, 6(1): 5-8.

Nadebaum, C., Anderson, V.Vajda, F. Reutens, D. & Wood, A. (2012) Neurobehavioral consequences of prenatal antiepileptic drug exposure. Developmental Neuropsychology, 37(1): 1-29.

Neubert, A., Fripp, J., Engstrom, C., Schwarz, R., Lauer, L., Salvado, O. and Crozier, S. (2012) Automated detection, 3D segmentation and analysis of high resolution spine MR images using statistical shape models. Physics in Medicine and Biology, 57 24: 8357-8376

Neubert, A., Salvado, O. Acosta, O. Bourgeat, P. & Fripp, J. (2012) Constrained reverse diffusion for thick slice interpolation of 3D volumetric MRI images. Computerized Medical Imaging and Graphics, 36(2): 130-138.

Ng, Arnold C. T., Auger, Dominique, Delgado, Victoria, van Elderen, Saskia G. C., Bertini, Matteo, Siebelink, Hans-Marc, van der Geest, Rob J., Bonetti, Cosimo, van der Velde, Enno T., de Roos, Albert, Smit, Johannes W.A., Leung, Dominic Y., Bax, Jeroen J. and Lamb, Hildo J. (2012) Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T1 mapping and subclinical myocardial dysfunction in diabetic patients a pilot study. Circulation: Cardiovascular Imaging, 5 1: 51-59.

Nguyen, C., Dakin, C.Yuill, M. Crozier, S. & Wilson, S. (2012) The effect of sigh on cardiorespiratory synchronization in healthy sleeping infants. Sleep, 35(12): 1643-1650.

Nguyen, C., Wilson, S. & Crozier, S. (2012) Automated quantification of the synchrogram by recurrence plot analysis. IEEE Transaction on Biomedical Engineering, 59(4): 946-955.

Nguyen, Phan, Bashirzadeh, Farzad, Hundloe, Justin, Salvado, Olivier., Dowson, Nicholas, Ware, Robert, Masters, Ian Brent, Bhatt, Manoj, Kumar, Aravind Ravi and Fielding, David (2012) Optical differentiation between malignant and benign lymphadenopathy by grey scale texture analysis of endobronchial ultrasound convex probe images. Chest, 141 3: 709-715

Pannek, K., Guzzetta, A.Colditz, P. & Rose, S. (2012) Diffusion MRI of the neonate brain: acquisition, processing and analysis techniques. Pediatric Radiology, 42(10): 1169-1182.

2012 Annual Report


Pannek, K., Raffelt, D.Bell, C. Mathias, J. & Rose, S. (2012) HOMOR: Higher Order Model Outlier Rejection for high b-value MR diffusion data. Neuroimage, 63(2): 835-842.

Peng, H., Thurecht, K. Blakey, I. Taran, E. & Whittaker, A. (2012) Effect of solvent quality on the solution properties of assemblies of partially fluorinated amphiphilic diblock copolymers. Macromolecules, 45(21): 8681-8690.

Pfrunder, M., Micallef, A., Rintoul, L., Arnold, D., Davy, K. & McMurtrie, J. (2012) Exploitation of the Menshutkin reaction for the controlled assembly of halogen bonded architectures incorporating 1,2-diiodotetrafluorobenzene and 1,3,5-triiodotrifluorobenzene. Crystal Growth and Design, 12(2): 714-724.

Pierens, G., Brossi, S.Yang, Z. Reutens, D. & Vegh, V. (2012) HSQC spectral based similarity matching of compounds using nearest neighbours and a fast discrete genetic algorithm. Journal of Cheminformatics, 4: 25.1-25.8.

Pierens, G., Venkatachalam, T., Bernhardt, P. Riley, M. & Reutens, D. (2012) A solid state study of keto-enol tautomerismin in three naphthaledene Schiff bases. Australian Journal of Chemistry, 65(5): 552-556.

Poole, M., While, P.Sanchez Lopez, H. & Crozier, S. (2012) Minimax current density gradient coils: analysis of coil performance and heating. Magnetic Resonance in Medicine, 68(2): 639-648.

Puttickx, S., Davis, A., Butler, K., Irvine, D., Licence, P. & Thurecht, K. (2013) The influence of domain segregation in ionic liquids upon controlled polymerisation mechanisms: RAFT polymerisation. Polymer Chemistry, 4(5): 1337-1344.

Raffelt, D., Tournier, J. Crozier, S. Connelly, A. & Salvado, O. (2012) Reorientation of fiber orientation distributions using apodized point spread functions. Magnetic Resonance in Medicine, 67(3): 844-855.

Raffelt, David, Tournier, J.-Donald, Rose, Stephen, Ridgway, Gerard R., Henderson, Robert, Crozier, Stuart, Salvado, Olivier and Connelly, Alan (2012) Apparent fibre density: A novel measure for the analysis of diffusion-weighted magnetic resonance images. NeuroImage, 59 4: 3976-3994

Rao, L., Li, S. Jiang, T. & Zhou, Y. (2012) Is payoff necessarily weighted by probability when making a risky choice? Evidence from functional connectivity analysis. PLoS One, 7(7): e41048.1-e41048.12.

Rathnayaka, K., Cowin, G. Schuetz, M. Sahama, T. & Schmutz, B. (2012) Correction of step artefact associated with MRI scanning of long bones. Medical Engineering & Physics, Article in press.

Reid, Christopher M., Storey, Elsdon, Wong, Tien Y., Woods, Robyn, Tonkin, Andrew, Wang, Jie J., Kam, Anthony, Janke, Andrew, Essex, Rowan, Abhayaratna, Walter P., Budge, Marc M. and on behalf of the ASPREE Study Group (2012) Aspirin for the prevention of cognitive decline in the elderly: Rationale and design of a neuro-vascular imaging study (ENVIS-ion). BMC Neurology, 12: 3.1-3.9.

Rose, Stephen, Pannek, Kerstin, Bell, Christopher, Baumann, Fusun, Hutchinson, Nicole, Coulthard, Alan, McCombe, Pamela and Henderson, Robert (2012) Direct evidence of intra- and interhemispheric corticomotor network degeneration in amyotrophic lateral sclerosis: An automated MRI structural connectivity study. NeuroImage, 59 3: 2661-2669

Rose, S., Rowland, T., Pannek, K., Baumann, F., Coulthard, A., McCombe, P. and Henderson, R. (2012) Structural hemispheric asymmetries in the human precentral gyrus hand representation. Neuroscience, 210 : 211-221

Scheck, S., Boyd, R. & Rose, S. (2012) New insights into the pathology of white matter tracts in cerebral palsy from diffusion magnetic resonance imaging: A systematic review. Developmental Medicine and Child Neurology, 54(8): 684-696.

Schenk, G., Mitic, N. Hanson, G. & Comba, P. (2013) Purple acid phosphatase: a journey into the function and mechanism of a colorful enzyme. Coordination Chemistry Reviews, 257(2): 473-482.

Schlipalius, David I., Valmas, Nicholas, Tuck, Andrew G., Jagadeesan, Rajeswaran, Ma, Li, Kaur, Ramandeep, Goldinger, Anita, Anderson, Cameron, Kuang, Jujiao, Zuryn, Steven, Mau, Yosep S., Cheng, Qiang, Collins, Patrick J., Nayak, Manoj K., Schirra, Horst Joachim, Hilliard, Massimo A. and Ebert, Paul R. (2012) A core metabolic enzyme mediates resistance to phosphine gas. Science, 338 6108: 807-810.

Schmid, A., Elliott, J. Strudwick, M. Little, M. & Coppieters, M. (2012) Effect of splinting and exercise on intraneural edema of the median nerve in carpal tunnel syndrome: An MRI study to reveal therapeutic mechanisms. Journal of Orthopaedic Research, 30(8): 1343-1350.

2012 Annual Report


Shao, T., Xia, L., Tao, G., Chi, J., Liu, F. & Crozier, S. (2012) Advanced three-dimensional tailored RF pulse design in volume selective parallel excitation. IEEE Transactions on Medical Imaging, 31(5): 997-1007.

Shekarabi, Masoud, Moldrich, Randal X., Rasheed, Sarah, Salin-Cantegrel, Adele, Laganiere, Janet, Rochefort, Daniel, Hince, Pascale, Huot, Karine, Gaudet, Rebecca, Kurniawan, Nyoman, Sotocinal, Susana G., Ritchie, Jennifer, Dion, Patrick A., Mogil, Jeffrey S., Richards, Linda J. and Rouleau, Guy A. (2012) Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum. Journal of Neuroscience, 32 11: 3865-3876

Shen, Kai-kai, Fripp, Jurgen, Meriaudeau, Fabrice, Chetelat, Gael, Salvado, Olivier, Bourgeat, Pierrick and The Alzheimer's Disease Neuroimaging Initiative (2012) Detecting global and local hippocampal shape changes in Alzheimer's disease using statistical shape models. Neuroimage, 59 3: 2155-2166.

Smith, Sarah J., Peralta, Rosely A., Jovito, Rafael, Horn, Adolfo, Bortoluzzi, Adailton J., Noble, Christopher J., Hanson, Graeme R., Stranger, Robert, Jayaratne, Vidura, Cavigliasso, German, Gahan, Lawrence R., Schenk, Gerhard, Nascimento, Otaciro R., Cavalett, Angelica, Bortolotto, Tiago, Razzera, Guilherme, Terenzi, Hernan, Neves, Ademir and Riley, Mark J. (2012) Spectroscopic and catalytic characterization of a functional (FeFeII)-Fe-III biomimetic for the active site of uteroferrin and protein cleavage. Inorganic Chemistry, 51 4: 2065-2078

Somerville, M., Katavic, P., Lambert, L., Pierens, G., Blanchfield, J., Cimino, G., Mollo, E., Gavagnin, M., Banwell, M.G., Garson, M.J. (2012) Isolation of thuridillins D-F, diterpene metabolites from the Australian sacoglossan mollusk Thuridilla splendens; relative configuration of the epoxylactone ring. Journal of Natural Products, 75(9): 1618-1624.

Song, M. & Jiang, T. (2012) A review of functional magnetic resonance imaging for Brainnetome. Neuroscience Bulletin, 28(4): 389-398.

Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, Bergmann Ø, Bernard M, Brown AA, Cannon DM, Chakravarty MM, Christoforou A, Domin M, Grimm O, Hollinshead M, Holmes AJ, Homuth G, Hottenga JJ, Langan C, Lopez LM, Hansell NK, Hwang KS, Kim S, Laje G, Lee PH, Liu X, Loth E, Lourdusamy A, Mattingsdal M, Mohnke S, Maniega SM, Nho K, Nugent AC, O'Brien C, Papmeyer M, Pütz B, Ramasamy A, Rasmussen J, Rijpkema M, Risacher SL, Roddey JC, Rose EJ, Ryten M, Shen L, Sprooten E, Strengman E, Teumer A, Trabzuni D, Turner J, van Eijk K, van Erp TG, van Tol MJ, Wittfeld K, Wolf C, Woudstra S, Aleman A, Alhusaini S, Almasy L, Binder EB, Brohawn DG, Cantor RM, Carless MA, Corvin A, Czisch M, Curran JE, Davies G, de Almeida MA, Delanty N, Depondt C, Duggirala R, Dyer TD, Erk S, Fagerness J, Fox PT, Freimer NB, Gill M, Göring HH, Hagler DJ, Hoehn D, Holsboer F, Hoogman M, Hosten N, Jahanshad N, Johnson MP, Kasperaviciute D, Kent JW Jr, Kochunov P, Lancaster JL, Lawrie SM, Liewald DC, Mandl R, Matarin M, Mattheisen M, Meisenzahl E, Melle I, Moses EK, Mühleisen TW, Nauck M, Nöthen MM, Olvera RL, Pandolfo M, Pike GB, Puls R, Reinvang I, Rentería ME, Rietschel M, Roffman JL, Royle NA, Rujescu D, Savitz J, Schnack HG, Schnell K, Seiferth N, Smith C, Steen VM, Valdés Hernández MC, Van den Heuvel M, van der Wee NJ, Van Haren NE, Veltman JA, Völzke H, Walker R, Westlye LT, Whelan CD, Agartz I, Boomsma DI, Cavalleri GL, Dale AM, Djurovic S, Drevets WC, Hagoort P, Hall J, Heinz A, Jack CR Jr, Foroud TM, Le Hellard S, Macciardi F, Montgomery GW, Poline JB, Porteous DJ, Sisodiya SM, Starr JM, Sussmann J, Toga AW, Veltman DJ, Walter H, Weiner MW; Alzheimer's Disease Neuroimaging Initiative; EPIGEN Consortium; IMAGEN Consortium; Saguenay Youth Study Group, Bis JC, Ikram MA, Smith AV, Gudnason V, Tzourio C, Vernooij MW, Launer LJ, DeCarli C, Seshadri S; Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium, Andreassen OA, Apostolova LG, Bastin ME, Blangero J, Brunner HG, Buckner RL, Cichon S, Coppola G, de Zubicaray GI, Deary IJ, Donohoe G, de Geus EJ, Espeseth T, Fernández G, Glahn DC, Grabe HJ, Hardy J, Hulshoff Pol HE, Jenkinson M, Kahn RS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Meyer-Lindenberg A, Morris DW, Müller-Myhsok B, Nichols TE, Ophoff RA, Paus T, Pausova Z, Penninx BW, Potkin SG, Sämann PG, Saykin AJ, Schumann G, Smoller JW, Wardlaw JM, Weale ME, Martin NG, Franke B, Wright MJ, Thompson PM; Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium.. (2012) Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics, 44(5): 552-561.

Sykes, Alex M., Palstra, Nick, Abankwa, Daniel, Hill, Justine M., Skeldal, Sune, Matusica, Dusan, Venkatraman, Prahatha, Hancock, John F. and Coulson, Elizabeth J. (2012) The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase. Journal of Biological Chemistry, 287 52: 43810-43824.

Takagi, M., Lubman, D., Walterfang, M., Barton, S., Reutens, D., Wood, A., Murat, Y. (2012) Corpus callosum size and shape alterations in adolescent inhalant users. Addiction Biology.

Tan, J., McMillan, N., Payne, E., Alexander, C., Heath, F., Whittaker, A., Thurecht, K. (2012) Hyperbranched polymers as delivery vectors for oligonucleotides. Journal of Polymer Science Part A: Polymer Chemistry, 50(13): 2585-2595.

Tesiram, Y., Lerner, M.Stewart, C. Njoku, C. & Brackett, D. (2012) Utility of nuclear magnetic resonance spectroscopy for pancreatic cancer studies. Pancreas, 41(3): 474-480.

Thurecht, K. (2012) Polymers as probes for multimodal imaging with MRI. Macromolecular Chemistry and Physics, 213(24): 2567-2572.

Trakic, A., Eskandarnia, N., Li, B., Weber, E., Wang, H. & Crozier, S. (2012) Rotational magnetic induction tomography. Measurement Science and Technology, 23(2): 025402.1-025402.12.

Trakic, A., Weber, E., Li, B., Wang, H., Liu, F., Engstrom, C., Crozier, S. (2012) Electromechanical design and construction of a rotating radio-frequency coil system for applications in magnetic resonance. IEEE Transactions on Biomedical Engineering, 59(4): 1068-1075.

2012 Annual Report

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Truong, V., Blakey, I. & Whittaker, A. (2012) Hydrophilic and amphiphilic polyethylene glycol-based hydrogels with tunable degradability prepared by "click" chemistry. Biomacromolecules, 13(12): 4012-4021.

Turner, M., Ullmann, J. & Kay, A. (2012) A method for detecting molecular transport within the cerebral ventricles of live zebrafish (Danio rerio) larvae. The Journal of Physiology, 590(10): 2233-2240.

Ullmann, Jeremy F. P., Keller, Marianne D., Watson, Charles, Janke, Andrew L., Kurniawan, Nyoman D., Yang, Zhengyi, Richards, Kay, Paxinos, George, Egan, Gary F., Petrou, Steven, Bartlett, Perry, Galloway, Graham J. and Reutens, David C. (2012) Segmentation of the C57BL/6J mouse cerebellum in magnetic resonance images. NeuroImage, 62 3: 1408-1414

Ullmann, J., Moore, B.Temple, S. Fernández-Juricic, E. & Collin, S. (2012) The retinal wholemount technique: A window to understanding the brain and behaviour. Brain, Behavior and Evolution, 79(1): 26-44.

Unni, Divya K., Piper, Michael, Moldrich, Randal X., Gobius, Ilan, Liu, Sha, Fothergill, Thomas, Donahoo, Amber-Lee S., Baisden, John M., Cooper, Helen M. and Richards, Linda J. (2012) Multiple Slits regulate the development of midline glial populations and the corpus callosum. Developmental Biology, 365 1: 36-49

Vadvalkar, S., Baily, C., Matsuzaki, S., West, M., Tesiram, Y. & Humphries, K. (2012) Metabolic inflexibility and protein lysine acetylation in heart mitochondria of a chronic model of Type 1 diabetes. Biochemical Journal, Article in press.

Vajjhala, P., Mirams, R. & Hill, J. (2012) Multiple Binding Sites on the Pyrin Domain of ASC Protein Allow Self-association and Interaction with NLRP3 Protein. Journal of Biological Chemistry, 287(50): 41732-41743.

van Hees, S., Angwin, A. McMahon, K. & Copland, D. (2013) A comparison of semantic feature analysis and phonological components analysis for the treatment of naming impairments in aphasia. Neuropsychological Rehabilitation, 23(1): 102-132.

van Schinkel, Linda D., Auger, Dominique, van Elderen, Saskia G. C., Marsan, Nina Ajmone, Delgado, Victoria, Lamb, Hildo J., Ng, Arnold C. T., Smit, Johannes W. A., Bax. Jeroen J., Westenber, Jos J. M. and de Roos, Albert (2012) Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis. International Journal of Cardiovascular Imaging, 29 3: 633-641.

Vegh, V., Glaser, P. Maillet, D. Cowin, G. & Reutens, D. (2012) High-field magnetic resonance imaging using solenoid radiofrequency coils. Magnetic Resonance Imaging, 30(8): 1177-1185.

Vegh, V., Kording, F. Venkatachalam, T. & Reutens, D. (2012) Magnetic susceptibility derived from T2 and T2*-weighted magnetic resonance magnitude images. Concepts in Magnetic Resonance Part B, 41B (1): 28-36.

Villain, Nicolas, Chetelat, Gael, Grassiot, Blandine, Bourgeat, Pierrick, Jones, Gareth, Ellis, Kathryn A., Ames, David, Martins, Ralph N., Eustache, Francis, Salvado, Olivier, Masters, Colin L., Rowe, Christopher C. and Villemagne, Victor L. (2012) Regional dynamics of amyloid-beta deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study. Brain, 135 7: 2126-2139

Wang, D., Rasoul, F., Hill, D., Hanson, G., Noble, C. & Whittaker, A. (2012) The role of residual Cu(II) from click-chemistry in the catalyzed hydrolysis of Boltorn polyester-based hydrogels. Soft Matter, 8(2): 435-445.

Wang, D., Varanasi, S., Hill, D., Rasoul, F., Symons, A. & Whittaker, A. (2012) The influence of composition on the physical properties of PLA-PEG-PLAco-Boltorn based polyester hydrogels and their biological performance. Journal of Materials Chemistry, 22(14): 6994-7004.

Wang, Jiaojian, Fan, Lingzhong, Zhang, Yu, Liu, Yong, Jiang, Di, Zhang, Yuanchao, Yu, Chunshui and Jiang, Tianzi (2012) Tractography-based parcellation of the human left inferior parietal lobule. NeuroImage, 63 2: 641-652.

Wang, Qifeng, Su, Tung-Ping, Zhou, Yuan, Chou, Kun-Hsien, Chen, I-Yun, Jiang, Tianzi and Lin, Ching-Po (2012) Anatomical insights into disrupted small-world networks in schizophrenia. NeuroImage, 59 2: 1085-1093.

Widiapradja, Alexander, Vegh, Viktor, Lok, Ker Zhing, Manzanero, Silvia, Thundyil, John, Gelderblom, Mathias, Cheng, Yi-Lin, Pavlovski, Dale, Tang, Sung-Chun, Jo, Dong-Gyu, Magnus, Tim, Chan, Sic L., Sobey, Christopher G., Reutens, David, Basta, Milan, Mattson, Mark P. and Arumugam, Thiruma V. (2012) Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways. Journal of Neurochemistry, 122 2: 321-332

Wilkinson, Lorine, Kurniwan, Nyoman D., Phua, Yu Leng, Nguyen, Michael J., Li, Joan, Galloway, Graham J., Hashitani, Hikaru, Lang, Richard J. and Little, Melissa H. (2012) Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice. Journal of Pathology, 227 4: 499-510

2012 Annual Report


Witkowski, Tomasz G., Thomas, James D., Delgado, Victoria, van Rijnsoever, Eva, Ng, Arnold C. T., Hoke, Ulas, Ewe, See H., Auger, Dominique, Yiu, Kai H., Holman, Eduard R., Klautz, Robert J. M., Schalij, Martin J., Bax, Jeroen J. and Marsan, Nina Ajmone (2012) Changes in left ventricular function after mitral valve repair for severe organic mitral regurgitation. Annals of Thoracic Surgery, 93 3: 754-760

Xie, B., Waters, M. & Schirra, H. (2012) Investigating potential mechanisms of obesity by metabolomics. Journal of Biomedicine and Biotechnology, 2012: 805683.1-805683.10.

Yang, Z., Richards, K. Kurniawan, N. Petrou, S. & Reutens, D. (2012) MRI-guided volume reconstruction of mouse brain from histological sections. Journal of Neuroscience Methods, 211(2): 2010-2017.

Yiu, Kai Hang, Atsma, Douwe E., Delgado, Victoria, Ng, Arnold C. T., Witkowski, Tomasz G., Ewe, See Hooi, Auger, Dominique, Holman, Eduard R., van Mil, Anneke M., Breuning, Martijn H., Tse, Hung Fat, Bax, Jeroen J., Schalij, Martin J. and Marsan, Nina Ajmone (2012) Myocardial structural alteration and systolic dysfunction in preclinical hypertrophic cardiomyopathy mutation carriers. PLoS One, 7 5:

Yong, K., Lambert, L.Hayes, P. De Voss, J. & Garson, M. (2012) Oxidative processes in the Australian marine sponge Plakinastrella clathrata: Isolation of plakortolides with oxidatively modified side chains. Journal of Natural Products, 75(3): 351-360.

Zhang, Yuanchao, Lin, Lei, Lin, Ching-Po, Zhou, Yuan, Chou, Kun-Hsien, Lo, Chun-Yi, Su, Tung-Ping and Jiang, Tianzi (2012) Abnormal topological organization of structural brain networks in schizophrenia. Schizophrenia Research, 141 2-3: 109-118

Zhang, Zengqiang, Liu, Yong, Jiang, Tianzi, Zhou, Bo, An, Ningyu, Dai, Haitao, Wang, Pan, Niu, Yixuan, Wang, Luning and Zhang, Xi (2012) Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity. NeuroImage, 59 2: 1429-1440

Zhao, Xiaohu, Liu, Yong, Wang, Xiangbin, Liu, Bing, Xi, Qian, Guo, Qihao, Jiang, Hong, Jiang, Tianzi and Wang, Peijun (2012) Disrupted small-world brain networks in moderate Alzheimer's disease: a resting-state fMRI study. PLoS One, 7 3: e33540.1-e33540.12

Zheng, Yu, Thurecht, Kristofer J., Chen, Xinyong, Roberts, Clive J., Irvine, Derek J., Howdle, Steven M. and Wang, Wenxin (2012) In situ formation of crosslinked core-corona polymeric nanoparticles from a novel hyperbranched core. Polymer Chemistry, 3 10: 2807-2814

Zhu, M., Xia, L., Liu, F., Zhu, J., Kang, L. & Crozier, S. (2012) A finite difference method for the design of gradient coils in MRI-an initial framework. IEEE Transactions On Biomedical Engineering, 59(9 Article No.6153352): 2412-2421.

Zuo, N., Cheng, J. & Jiang, T. (2012) Diffusion magnetic resonance imaging for Brainnetome: a critical review. Neuroscience Bulletin, 28(4): 375-388.

Zuo, Nianming, Fang, Jiliang, Lv, Xueyu, Zhou, Yuan, Hong, Yang, Li, Tao, Tong, Haibing, Wang, Xiaoling, Wang, Weidong and Jiang, Tianzi (2012) White matter abnormalities in major depression: a tract-based spatial statistics and rumination study. PLoS One, 7 5: e37561.1-e37561.7

Freeman, R., Varanasi, S.Meyers, I. & Symons, A. (2012) Effect of air abrasion and thermocycling on resin adaptation and shear bond strength to dentin for an etch-and-rinse and self-etch resin adhesive. Dental Materials Journal, 31(2): 180-188.

Wang, D., Hill, D., Rasoul, F. & Whittaker, A. (2012) Synthesis of a new hyperbranched, vinyl macromonomer through the use of click chemistry: Synthesis and characterization of copolymer hydrogels with PEG diacrylate. Journal of Polymer Science Part A: Polymer Chemistry, 50(6): 1143-1157.

Zhang, B., Dhital, S. Haque, E. & Gidley, M. (2012) Preparation and characterization of gelatinized granular starches from aqueous ethanol treatments. Carbohydrate Polymers, 90(4): 1587-1594.

2012 Annual Report

CENTRE FOR ADVANCED IMAGING

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