CELSI®, CELL SIGNALING

AN INTERACTIVE PLATFORM FOR SIMULATIONOF SIGNAL TRANSDUCTION CASCADES

Arturo Manzo-Fontes / Spleißen Wege Bio

SPLEI EN WEGE BIO, S. DE R.L. DE C.V.ẞ

WHAT EXACTLY IS CELSI®?CELSI® is a computer–assisted platform to simulate Signal Transduction (ST) pathways, occurring in living cells, and derived from an extracellular stimulus triggering a protein reaction signal cascade to the interior of the cell causing gene expression and producing a cellular response.

HOW CELSI® WORKS?CELSI® can be used over the Internet via a website. Once the user is registered, the platform loads the program as user's working session. When the user leaves the session, all operations and changes made by the user are stored in their account for future work, allowing to maintain the preferred user settings.

TO WHOM CELSI® IS USEFUL?CELSI® is highly useful for graduate students, researchers in biomedical sciences, universities with biochemistry programs, i.e., chemistry and biochemistry of proteins, proteomics, and metabolomics, and multinational organizations in biomedical sciences worldwide as well. Private corporations working in drug discovery, will find in CELSI® a potent tool for virtual simulation saving time and monetary resources for their developments.

MOVING EXPERIMENTAL CHEMISTRY INTO CYBERSPACE SHOULD

BE OF CLEAR IMPORTANCE  TO BIOMEDICAL SCIENCE...ONE OF THE MOST OBVIOUS APPLICATIONS ... IS THE DESIGN

OF BETTER BINDING DRUGS ...

Michael Levitt (co-recipient of Nobel Prize of Chemistry 2013)

“

How CELSI® can help to scientific community in protein 3D modeling?

CELSI®

A state-of-the-art and interactive platform for animation of cellular signal transduction cascades crucial to understand complex disorders occurring in human organism.

CELSI® is a fully computer – assisted animation and interactive

software that display 3D biochemical molecules, i.e.,

proteins, lipids, carbohydrates,and nucleic acids.

CELSI® displays 3D cellular structures, e.g., membrane

structures, organelles, filaments, etc., based on scientific data

(e.g., EM, X-rays crystallography and NMR spectroscopy)

CELSI® is fully compatible withdifferent platforms, e.g., C++, Jmol,

Rasmol, Flash, Cn3D, Java™, etc.and can be run in mobile devices,(e.g., PDAs, tablets, laptops, and

smartphones)

A powerful tool to access scientific information, e.g.:

Physical, chemical, biochemical and genetic information,

cell signal reaction kinetics, human diseases, etc.

Link to scientific institutions and multinational organizations, such

as: CDC, EMBO, GOLM Metabolome Database, Human Genome Project, NCBI, NIGMS,

NIH, Uniprot, etc.

Access to several data bases including: EMBL, Gene Bank,

Medline, Prosite, KEGG, OMIM, Lipid Bank, PDB, HUGO, Swiss 2D

Gel Swiss-Prot, etc.

MULTISCALE MODELING OF THE ACTION OF MOLECULAR COMPLEXES  IS LIKELY TO BE USED IN DESCRIBING SIGNAL TRANSDUCTION, AND ALLOWING ONE TO HAVE  A CLEARER

AND CLEARER UNDERSTANDING OF CELLULAR ACTION.

Arieh Warshel (co-recipient of Nobel Prize of Chemistry 2013)

“

MARKET SIZE

 (Source: European Commission reports)

THE  VIRTUAL REALITY  INDUSTRY IS GROWING AT A FAST PACE, WITH REVENUES

PROJECTED TO INCREASE FROM 90 MILLION U.S.

DOLLARS IN 2014 TO 5.2 BILLION U.S. DOLLARS IN

2018.(Source: Statista, Inc.)

“

MARKET SIZE AND SHARE

* Thousands of $ USD

BUSINESS MODEL

1. Access to CELSI® through SWB website2. Annual and multiannual subscriptions3. Single-users: undergraduate and graduate students, academic

staff, researchers, individuals, etc.4. Institutional-users: universities, multinational organizations, private

corporations, etc.

BENCHMARKING I

a) VCELL: It is not a 3D modeling tool but oriented to theoretical biophysicists.

b) GEPASI: It is not a 3D modeling software. It runs math models of cell biochemistry.

c) CELLERATOR: Generates 3D models from signal transduction networks. It is not a 3D modeling tool.

d) Jmol: Represents 3D models of chemical molecules, one per screen, but not cell structures.

e) Cn3D: Generates 3D models of molecules, one per screen. Not designed for cell structures.

CELSI® allows virtual simulation through 3D animation of molecules and cell structures.

BENCHMARKING II

a) VCELL: It is not compatible to any 3D modeling software.

b) GEPASI: It is not compatible to any 3D modeling software.

c) CELLERATOR: Non compatible with current systems for 3D animation. Runs under Mathematica® 4.0 OS, or higher.

d) Jmol: Compatible only with Rasmol and Jmol environments.

e) Cn3D: Compatible only with Cn3D environment.

CELSI® is compatible with C++, Jmol, Rasmol, Flash, Cn3D, Java™, etc.

BENCHMARKING III

a) VCELL: Does not provide links to Organizations, only provides bibliographic references.

b) GEPASI: Only provides a few links related to bioinformatics.

c) CELLERATOR: Does not give access to information or web sites.

d) Jmol: Does not give science information, only refers some Organizations from its databases.

e) Cn3D: Does not give scientific information, only refers to NCBI databases.

CELSI® allows direct access to scientific information about cell structures and molecules. Links to over 50 Web sites.

BENCHMARKING IV

a) VCELL: Only provides tutorial files and an Email address for questions.

b) GEPASI: Provides tutorial files and a link with F.A.Q. for software users.

c) CELLERATOR: Provides only a Reference Manual and guides for mathematical equations.

d) Jmol: Provides an Email address for help only to use the software.

e) Cn3D: Provides only an Email address for help.

CELSI® platform allows a permanent user backup through CELSI-SWB webpage either ‘on line’ or Email.

CELSI® UNIVERSE

UNIVERSE OF POTENTIAL USERS

 (Source: European Commission web page)

GROWTH

Thou

sand

s of U

S do

llars

FINANCIAL PROJECTIONS, $ USD

% Growth in Sales and Profits

Universities with Graduate programs in biomedical sciences:

•Single & multi-user versions•Annual and multiannual

subscription•Participation in research and

academic programs

Research Organisms in Biopharmaceutical Sciences:

•Single & multi-user versions•Annual and multiannual

subscription•Contracts for custom simulation

developments

Biotech firms with R&D departments in drug discovery:

•Multi-user versions•Annual and multiannual

subscription•Contracts for custom simulation

developments

TARGET MARKETS FOR CELSI®

Arturo Manzo-Fontes, Ph.D.Chief Operating Officer and Vice–President of SPLEI EN WEGE BIO, S DE RL DE CVẞ

Leader of CELSI® project

Carlos A. Manzo Fontes, MBAChief Executive Officer and President

of SPLEI EN WEGE BIO, S DE RL ẞDE CV

BAKLIGHTA study of film production services.

Focused on digital solutions such as project development in 3D

animation, and postproduction.

ONE SIMPLE IDEAA digital creative agency specializing

in development of communication strategies through interactive

projects, art and 2D animation.

ADVANCED INTEGRATED SYSTEMSA Mexican company that provides

consulting, and design and development of solutions based on

high-quality software.

AMOUNT OF RESOURCES TO BE FUNDED: $300,000 USD

◉ Furniture, hardware, software, peripherals

◉ Staff recruitment

◉ External contracts

◉ Marketing

◉ Operations

RESOURCES ADMINISTRATION

GOOD, BAD OR INDIFFERENT, IF YOU ARE NOT INVESTING IN NEW TECHNOLOGY, YOU ARE GOING TO BE LEFT BEHIND.

Philip Green

“