Cell Signaling. Local Signaling Paracrine Paracrine Synaptic Synaptic.
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Transcript of Cell Signaling. Local Signaling Paracrine Paracrine Synaptic Synaptic.
Cell Signaling
Local Signaling
Paracrine Synaptic
Long-distance Signaling
Endocrine
Hormones
Stages of Cell Signaling
Stages of Cell Signaling Reception
Ligand (signaling molecule) binds to receptor protein RP shape change stimulates transduction pathway
Stages of CellSignaling
Intracellular reception Nonpolar signals bind to
receptors in cytosol or nucleus
Stages of Cell Signaling
Transduction Various molecules relay signal to response location
Inactivekinase 1 Phosphorylation cascade
Inactivekinase 2
Activekinase 1
Activekinase 2
Activeenzyme
Inactiveenzyme
Cellularresponse
ADP
ADP
Activated relay molecule
Stages of Cell Signaling
PhosphorylationKinase activates molecule by adding a phosphate group
Inactivekinase 1 Phosphorylation cascade
Inactivekinase 2
Activekinase 1
Activekinase 2
Activeenzyme
Inactiveenzyme
Cellularresponse
ADP
ADP
Activated relay molecule
Stages of Cell Signaling
DephosphorylationPhosphatase deactivates molecule by removing a phosphate group
Stages of Cell Signaling
Response
Stages ofCell Signaling