CAPSULE CAMERA

What is capsule endoscopy

bullCapsule endoscopy is a novel noninvasive technology designed primarily to provide diagnostic imaging

This Miniature Ingestible Camera was conceived by Tarun Mullick developed in late 1980s with the help of gastroenterologist Dr Sudhir Dutta

HISTORY

The Camera Pill

Swallowable Camera Capsule from Given Imaging including Zarlinkrsquos ULP RF Transmitter

Specifications Diameter of 10 mm and a Length of 20 mm

Bullet shape - This shape and its diameter are critical for mapping the small intestine

Uses Silver oxide button batteries - high energy density amp disposable

Made up of biocompatible material

Features of the Capsule

bull Capsule takes two images per secondbull On average 50000 images are

obtained during an 8 hour exambull Magnification 8xbull Capsule coating non-adherantbull Disposable

CONSTRUCTION OF CAPSULE CAMERA

- HAS 8 PARTS

Capsule Electronics 1Optical dome2 Lens holder 3 Lens 4Illuminating LEDs5 CMOS imager6 Battery7 ASIC transmitter8 Antenna

CAPSULE CAMERA(Internal view)

1Optical Dome

Front part of capsule Bullet shaped

Easy orientation Easy propelling

2Lens Holder

Lens Holder holds lens tightly amp avoids its dislocation

3Lens

Arranged behind Light Receiving Window

Focuses light on the CMOS Image Sensor behind it

4CMOS Image Sensor

PIXELARRAY

OSCILLATINGCIRCUIT

CURRENTLIMITINGCIRCUIT

CONTROLCIRCUIT

CODING CIRCUIT

SWITCHINGCIRCUIT

READCIRCUIT

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

What is capsule endoscopy

bullCapsule endoscopy is a novel noninvasive technology designed primarily to provide diagnostic imaging

This Miniature Ingestible Camera was conceived by Tarun Mullick developed in late 1980s with the help of gastroenterologist Dr Sudhir Dutta

HISTORY

The Camera Pill

Swallowable Camera Capsule from Given Imaging including Zarlinkrsquos ULP RF Transmitter

Specifications Diameter of 10 mm and a Length of 20 mm

Bullet shape - This shape and its diameter are critical for mapping the small intestine

Uses Silver oxide button batteries - high energy density amp disposable

Made up of biocompatible material

Features of the Capsule

bull Capsule takes two images per secondbull On average 50000 images are

obtained during an 8 hour exambull Magnification 8xbull Capsule coating non-adherantbull Disposable

CONSTRUCTION OF CAPSULE CAMERA

- HAS 8 PARTS

Capsule Electronics 1Optical dome2 Lens holder 3 Lens 4Illuminating LEDs5 CMOS imager6 Battery7 ASIC transmitter8 Antenna

CAPSULE CAMERA(Internal view)

1Optical Dome

Front part of capsule Bullet shaped

Easy orientation Easy propelling

2Lens Holder

Lens Holder holds lens tightly amp avoids its dislocation

3Lens

Arranged behind Light Receiving Window

Focuses light on the CMOS Image Sensor behind it

4CMOS Image Sensor

PIXELARRAY

OSCILLATINGCIRCUIT

CURRENTLIMITINGCIRCUIT

CONTROLCIRCUIT

CODING CIRCUIT

SWITCHINGCIRCUIT

READCIRCUIT

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

This Miniature Ingestible Camera was conceived by Tarun Mullick developed in late 1980s with the help of gastroenterologist Dr Sudhir Dutta

HISTORY

The Camera Pill

Swallowable Camera Capsule from Given Imaging including Zarlinkrsquos ULP RF Transmitter

Specifications Diameter of 10 mm and a Length of 20 mm

Bullet shape - This shape and its diameter are critical for mapping the small intestine

Uses Silver oxide button batteries - high energy density amp disposable

Made up of biocompatible material

Features of the Capsule

bull Capsule takes two images per secondbull On average 50000 images are

obtained during an 8 hour exambull Magnification 8xbull Capsule coating non-adherantbull Disposable

CONSTRUCTION OF CAPSULE CAMERA

- HAS 8 PARTS

Capsule Electronics 1Optical dome2 Lens holder 3 Lens 4Illuminating LEDs5 CMOS imager6 Battery7 ASIC transmitter8 Antenna

CAPSULE CAMERA(Internal view)

1Optical Dome

Front part of capsule Bullet shaped

Easy orientation Easy propelling

2Lens Holder

Lens Holder holds lens tightly amp avoids its dislocation

3Lens

Arranged behind Light Receiving Window

Focuses light on the CMOS Image Sensor behind it

4CMOS Image Sensor

PIXELARRAY

OSCILLATINGCIRCUIT

CURRENTLIMITINGCIRCUIT

CONTROLCIRCUIT

CODING CIRCUIT

SWITCHINGCIRCUIT

READCIRCUIT

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

The Camera Pill

Swallowable Camera Capsule from Given Imaging including Zarlinkrsquos ULP RF Transmitter

Specifications Diameter of 10 mm and a Length of 20 mm

Bullet shape - This shape and its diameter are critical for mapping the small intestine

Uses Silver oxide button batteries - high energy density amp disposable

Made up of biocompatible material

Features of the Capsule

bull Capsule takes two images per secondbull On average 50000 images are

obtained during an 8 hour exambull Magnification 8xbull Capsule coating non-adherantbull Disposable

CONSTRUCTION OF CAPSULE CAMERA

- HAS 8 PARTS

Capsule Electronics 1Optical dome2 Lens holder 3 Lens 4Illuminating LEDs5 CMOS imager6 Battery7 ASIC transmitter8 Antenna

CAPSULE CAMERA(Internal view)

1Optical Dome

Front part of capsule Bullet shaped

Easy orientation Easy propelling

2Lens Holder

Lens Holder holds lens tightly amp avoids its dislocation

3Lens

Arranged behind Light Receiving Window

Focuses light on the CMOS Image Sensor behind it

4CMOS Image Sensor

PIXELARRAY

OSCILLATINGCIRCUIT

CURRENTLIMITINGCIRCUIT

CONTROLCIRCUIT

CODING CIRCUIT

SWITCHINGCIRCUIT

READCIRCUIT

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Specifications Diameter of 10 mm and a Length of 20 mm

Bullet shape - This shape and its diameter are critical for mapping the small intestine

Uses Silver oxide button batteries - high energy density amp disposable

Made up of biocompatible material

Features of the Capsule

bull Capsule takes two images per secondbull On average 50000 images are

obtained during an 8 hour exambull Magnification 8xbull Capsule coating non-adherantbull Disposable

CONSTRUCTION OF CAPSULE CAMERA

- HAS 8 PARTS

Capsule Electronics 1Optical dome2 Lens holder 3 Lens 4Illuminating LEDs5 CMOS imager6 Battery7 ASIC transmitter8 Antenna

CAPSULE CAMERA(Internal view)

1Optical Dome

Front part of capsule Bullet shaped

Easy orientation Easy propelling

2Lens Holder

Lens Holder holds lens tightly amp avoids its dislocation

3Lens

Arranged behind Light Receiving Window

Focuses light on the CMOS Image Sensor behind it

4CMOS Image Sensor

PIXELARRAY

OSCILLATINGCIRCUIT

CURRENTLIMITINGCIRCUIT

CONTROLCIRCUIT

CODING CIRCUIT

SWITCHINGCIRCUIT

READCIRCUIT

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Features of the Capsule

bull Capsule takes two images per secondbull On average 50000 images are

obtained during an 8 hour exambull Magnification 8xbull Capsule coating non-adherantbull Disposable

CONSTRUCTION OF CAPSULE CAMERA

- HAS 8 PARTS

Capsule Electronics 1Optical dome2 Lens holder 3 Lens 4Illuminating LEDs5 CMOS imager6 Battery7 ASIC transmitter8 Antenna

CAPSULE CAMERA(Internal view)

1Optical Dome

Front part of capsule Bullet shaped

Easy orientation Easy propelling

2Lens Holder

Lens Holder holds lens tightly amp avoids its dislocation

3Lens

Arranged behind Light Receiving Window

Focuses light on the CMOS Image Sensor behind it

4CMOS Image Sensor

PIXELARRAY

OSCILLATINGCIRCUIT

CURRENTLIMITINGCIRCUIT

CONTROLCIRCUIT

CODING CIRCUIT

SWITCHINGCIRCUIT

READCIRCUIT

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

CONSTRUCTION OF CAPSULE CAMERA

- HAS 8 PARTS

Capsule Electronics 1Optical dome2 Lens holder 3 Lens 4Illuminating LEDs5 CMOS imager6 Battery7 ASIC transmitter8 Antenna

CAPSULE CAMERA(Internal view)

1Optical Dome

Front part of capsule Bullet shaped

Easy orientation Easy propelling

2Lens Holder

Lens Holder holds lens tightly amp avoids its dislocation

3Lens

Arranged behind Light Receiving Window

Focuses light on the CMOS Image Sensor behind it

4CMOS Image Sensor

PIXELARRAY

OSCILLATINGCIRCUIT

CURRENTLIMITINGCIRCUIT

CONTROLCIRCUIT

CODING CIRCUIT

SWITCHINGCIRCUIT

READCIRCUIT

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Capsule Electronics 1Optical dome2 Lens holder 3 Lens 4Illuminating LEDs5 CMOS imager6 Battery7 ASIC transmitter8 Antenna

CAPSULE CAMERA(Internal view)

1Optical Dome

Front part of capsule Bullet shaped

Easy orientation Easy propelling

2Lens Holder

Lens Holder holds lens tightly amp avoids its dislocation

3Lens

Arranged behind Light Receiving Window

Focuses light on the CMOS Image Sensor behind it

4CMOS Image Sensor

PIXELARRAY

OSCILLATINGCIRCUIT

CURRENTLIMITINGCIRCUIT

CONTROLCIRCUIT

CODING CIRCUIT

SWITCHINGCIRCUIT

READCIRCUIT

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

1Optical Dome

Front part of capsule Bullet shaped

Easy orientation Easy propelling

2Lens Holder

Lens Holder holds lens tightly amp avoids its dislocation

3Lens

Arranged behind Light Receiving Window

Focuses light on the CMOS Image Sensor behind it

4CMOS Image Sensor

PIXELARRAY

OSCILLATINGCIRCUIT

CURRENTLIMITINGCIRCUIT

CONTROLCIRCUIT

CODING CIRCUIT

SWITCHINGCIRCUIT

READCIRCUIT

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

2Lens Holder

Lens Holder holds lens tightly amp avoids its dislocation

3Lens

Arranged behind Light Receiving Window

Focuses light on the CMOS Image Sensor behind it

4CMOS Image Sensor

PIXELARRAY

OSCILLATINGCIRCUIT

CURRENTLIMITINGCIRCUIT

CONTROLCIRCUIT

CODING CIRCUIT

SWITCHINGCIRCUIT

READCIRCUIT

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

3Lens

Arranged behind Light Receiving Window

Focuses light on the CMOS Image Sensor behind it

4CMOS Image Sensor

PIXELARRAY

OSCILLATINGCIRCUIT

CURRENTLIMITINGCIRCUIT

CONTROLCIRCUIT

CODING CIRCUIT

SWITCHINGCIRCUIT

READCIRCUIT

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

4CMOS Image Sensor

PIXELARRAY

OSCILLATINGCIRCUIT

CURRENTLIMITINGCIRCUIT

CONTROLCIRCUIT

CODING CIRCUIT

SWITCHINGCIRCUIT

READCIRCUIT

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

5Battery

Made of ZincAlkaline ElectrolyteSilver Oxide Has discharge voltage disposable and doesnrsquot cause harm to the body

Button shaped amp two in number

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

6ASIC Transmitter

The ASIC (Application Specific Integrated Circuit) Transmitter Two Transmitting Electrodes are connected to the outlines of the ASIC TransmitterThese electrodes are electrically isolated from each other

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

7Antennae

As shown the Antennae is arranged at the end of the capsule Itis enclosed in a dome shaped chamber The Antennae receives the data from the ASIC Transmitter and sends it to the Data Recorder tied to the patientrsquos waist

The dome containing the Antennae is made of non conducting material which is harmless to the human body

Parylene coated onto polyethylene or polypropylene is used

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

PillCam Platform Componentsbull PillCam ESO or SBbull Data Recorderbull Given Workstationbull RAPID Software

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Data Recorder with pick up antennae amp a Computer

A view of Data Recorder being mounted on a belt pack tied to the patientrsquos waist

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

SB 2 with RAPID 4

SB 2 with RAPID 5

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Improved Diagnostic ConfidenceRAPID Atlasbull All images reviewed

and labeled byphysician advisorypanelbull Enables side-by-sidecomparison of caseimage to knownpathologybull Searchable by CapsuleEndoscopy StructuredTerminology (CEST)findings and diseases

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

TYPES AND APPLICATION

-4 TYPES

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

PillcamSB

bullApproved by FDA in 2001bullSize-11mm x 26 mmbullWeight-37 gramsbullOne-sided imagingbullTwo pictures per secondbull18 magnificationbull140 degree field of viewbullOver 50000 images in 8 hoursbullPillcamSB 2-cleared by FDA May 2007-offers wider field of view and improved optics

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

PillcamESO

bullApproved by the FDA in 2004bullSize 11mm x 26mmbullWeight-37 gramsbullTwo sided photographybull14 images per secondbull2600 pictures in 20 minutesbullPillcamESO 2-cleared by FDA May 2007-offers wider field of view and 18 images per second

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Agile Patency CapsulebullSame size as actual video capsulebullComposed of lactosebullContains a timer radiofrequency identification tag and radio-opaque materialbullCan be seen by plain abdominal film or by special handheld radiofrequency detectorbullDesigned to progressively dissolve after 40 hours of contact with digestive secretionsbullDisintegrates completely between 80 and 100 hoursbullAllows localization of site of stenosis before video capsulebullNot considered standard of practice

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

PillCamtrade SB- Crohns Disease Small bowel tumors Small bowel injury Celiac Disease Mal-Absorption Disorders Vascular Disorders Ulcerative Colitis

PillCamtrade ESO -esophageal diseases gastro esophageal reflux disease Barretts esophagus PillCamtrade COLON- colon

Agiletrade patency capsule- intestinal patency

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

EXISTING PRODUCTS1OMOM 2M2A

3PILLCAM 4NORIKA35MTSI

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Preparation

Patient fasts overnight or for at least 12 hoursNo iron pills for 5 days or olestraColyte prep clear liquid diet at noon 23 gallon colyteat 6 PM 4 hours prior to capsule take 13 gallon colyteand 2 simethicone tabletsMagnesium Citrate prep clear liquid diet at noon 1 bottle of magnesium citrate followed by 1 bottle of gatoradeat 6 PM 8 PM and 4 hours prior to capsule with 2 simethicone tablets 4 hours prior

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Procedure for PillcamSB

bullPatient comes to endoscopy centerbull8-lead antenna placed on patient and battery pack placed on patientbullPatient swallows pill and leaves unitbullCan ingest liquids 2 hours after capsule takenbullCan eat food 4 hours after capsule takenbullPatient brings back recorder approximately 8 hours after ingestionbullPatient does NOT recover capsulebullRecorder then downloaded onto computer which can take 25 to 3 hoursbullCapsule then read on computer

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Procedure for PillcamESO

bullPatient swallows the pill while lying down with little or no waterbullThe patient is then slowly elevatedbullThis allows for the capsule to spend a longer time in the esophagus and therefore allow for better visualization of the esophagus

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Endoscopy Procedure

Capsule is swallowed by the patient like a conventional pill

It takes images as it is propelled forward by peristalsis

A wireless recorder worn on a belt receives the images

transmitted by the pill

A computer workstation processes the data and produces a

short video clip or still images

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

The Diagnostic Procedure

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Capsule Imagingbull Moved by peristalsisbull 2Hz 576 X576 color imagebull Typical studies are around 6-8hoursbull 10000s of images from eachstudybull Somewhat cumbersome to

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

In approximately eight hours thepatient will return to the clinic forremoval of equipment

900 am 500 pm

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Advantages

Painless no side affects or complications

Miniature size so can move easily through the digestive system

Accurate precise amp low power consumption

Images taken are of very high quality which are sent almost instantaneously to the data recorder for storage Made of bio compatible material doesnrsquot cause any harm to the body

The procedure is simple

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Use of Suspected Blood Indicator (SBI)which add no cost AdvanCE (Advance CE) for patients unable to swallow

High sensitivity and specificity for detecting lesions

CE avoids the risks associated with sedation and radiation

It is noninvasive and may not require the patient to miss work

Reducing physician reading times and improving cost-effectiveness

More efficient than normal endoscopythe X ray or the CT scan

Remote interpretation for rural settings

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Image Spectrum PillCam Capsule Endoscopy

BleedingSuspected Crohnrsquos

Tumors

Celiac Disease

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Capsule Endoscopy Versus Other Imaging Modalities

Study Yield

Capsule vs Ileoscopy 61 vs 46

Capsule vs Push enterosc 51 vs 7

Capsule vs CT enterography 75 vs 37

Capsule vs Small bowel MRI 60 vs 40

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Disadvantages

Gastrointestinal obstructions and swallowing disorders prevent free flow of capsule through the digestive system

Patients with pacemakers pregnant women and all pediatrics have to be monitored continuously while taking the capsule

The M2A procedure is not a replacement for Colonoscopy

It is not reusable Capsule obstruction which necessitate surgical removal More expensive than the other procedures

Batteries may not last long

Presence of cardiac pacemakers and cardiac defibrillators could lead to corruption and loss of the transmitted data

MRI not possible while the capsule inside the patients body

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

CAPSULE ENDOSCOPY RETENTION

bull Capsule retained proximal to an intestinal narrowing for at least TWO WEEKS

bull Untreated may be permanent

bull Capsule removal requires medical endoscopic or surgical intervention

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Future Improvements

Equipping the capsule with a LASER

Adding additional features like Zooming amp Auto Focus

Can be used in Restorative Surgery amp Pharmacological Intervention

Further reduction in size using Nano TechnologyMaking it cost effective

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

SB2 with new features mmRAPIDreg REAL TIME VIEWERLabeling the bowel wall sample luminal contents biopsy the mucosa provide therapeutic ablation of lesions or control the movement of the device Evaluation of celiac sprue and chronic abdominal pain Longer battery half-life Humanoid robot Capsule camera with telemetric capacities Making it cost effective

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

RAPIDreg REAL TIMEVIEWER1048714 Remote Patient Check-in1048714 Real-time viewing1048714 Data Transfer to GDS1048714 PillCam ESO Viewing

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

Conclusion

The Endoscopy capsule is a pioneering concept for Medical Technology of the 21st century

The endoscopy system is the first of its kind to be able to provide non-invasive imaging of the entire small intestine

It has revolutionized the field of diagnostic imaging to a great extent and has proved to be of great help to physicians all over the world

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU

THANK YOU

• CAPSULE CAMERA
• Slide 2
• Slide 3
• Slide 4
• The Camera Pill Swallowable Camera Capsule from Given I
• Slide 6
• Slide 7
• CONSTRUCTION OF CAPSULE CAMERA - HAS 8 PARTS
• Slide 9
• Slide 10
• Slide 11
• Slide 12
• Slide 13
• Slide 14
• Slide 15
• Slide 16
• Slide 17
• Slide 18
• Slide 19
• Slide 20
• Slide 21
• TYPES AND APPLICATION
• Slide 23
• Slide 24
• Slide 25
• Slide 26
• Slide 27
• Existing products
• Slide 29
• Slide 30
• Slide 31
• Slide 32
• The Diagnostic Procedure
• Slide 34
• Slide 35
• Slide 36
• Slide 37
• Slide 38
• Slide 39
• Slide 40
• Slide 41
• Slide 42
• Slide 43
• Slide 44
• Slide 45
• Slide 46
• Slide 47
• Slide 48
• Slide 49
• Slide 50
• THANK YOU