Linkedinmarketingoverviewjasminesandler 13499986125162-phpapp02-121011184038-phpapp02
Capsule 130802054344-phpapp02 sam
-
Upload
samaira-mujeeb -
Category
Documents
-
view
48 -
download
0
Transcript of Capsule 130802054344-phpapp02 sam
![Page 1: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/1.jpg)
Slide 1
TOPIC NAME :CAPUSLE
• Sumitted to:
Dr.Khizar Hayyat
Submitted By:
Zulcaif Ahmad & Saqib Hafeez
(696) (719)
![Page 2: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/2.jpg)
Slide 2
• Developing and preparing the formulation and selecting the capsule size
• Filling the capsule shells
• Capsule sealing(optional)
• Cleaning and polishing the filled capsules
![Page 3: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/3.jpg)
Slide 3
Developing and preparing the formulation and selecting the capsule size
uniform powder
Diluent or filler
Disintegrants
Lubricant or Glidant
Wetting and Solublizing
agent
Coating agent
![Page 4: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/4.jpg)
Slide 4
000 00 o
1 2 3
4 5
![Page 5: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/5.jpg)
Slide 5
Filling Hard Capsule Shells
Punch method.
• When filling a small number of capsules in the pharmacy
• takes the precise number of empty capsules to be filled from the stock container.
Machines
• Machines developed for industrial use automatically separate the caps from empty capsules, fill the bodieS
![Page 6: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/6.jpg)
Slide 6
Filling Hard Capsule Shells
Punched vertically
Hold capsule between the thumb and forefinger
Mix with spatula
Powder place on a clean paper or glass or porcelain plate
Punch method
Empty capsules
![Page 7: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/7.jpg)
Slide 7
![Page 8: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/8.jpg)
Slide 8
Filling Hard Capsule Shells
Hand-operated capsule filling machines or Feton capsule filling
machine
Consist of a couple of plates are capable of producing about
200 to 2000capsules/hr.
![Page 9: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/9.jpg)
Slide 9
OSAKA MODEL R-180
SEMI AUTOMATIC CAPSULE
FILLING MACHINE
![Page 10: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/10.jpg)
Slide 10
![Page 11: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/11.jpg)
Slide 11
Capsule Sealing
• that fuses the capsule cap to the body through the double wall thickness at their juncture The process results in a distinctive ring around the capsule where heat welded.
Heat-welding process
• that lowers the melting point in the contact areas of the capsule’s cap and body and then thermally bonds the two parts using low temperatures
Liquid wetting agent
![Page 12: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/12.jpg)
Slide 12
Capsule Sealing
Heat-welding process
Fuse the cap & body through double wall
thickness at their juncture
distinctive ring around the capsule where heat
welded
Liquid wetting agent
lowers the melting point in contact areas
thermally bonds two parts using low temperatures
(40°C–45°C).
![Page 13: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/13.jpg)
Slide 13
Cleaning and Polishing Capsules
• On a small scale, capsules may be cleaned individually or in small numbers by rubbing them with a clean gauze or cloth.
On small Scale
• Many capsule-filling machines are affixed with a cleaning vacuum that removes any extraneous material from the capsules as they exit the equipment. industrial cleaning and polishing of filled hard capsules using the Accela-Cota apparatus.
On large scale
![Page 14: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/14.jpg)
Slide 14
Cleaning and Polishing Capsules
On small scale
Cleaned individuallyin small numbers
Rubbing with a clean gauze or cloth.
On large scale
Cleaning vacuum affixed with filling machine
cleaning and polishing by Accela-Cota apparatus.
![Page 15: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/15.jpg)
Slide 15
![Page 16: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/16.jpg)
Slide 16
![Page 17: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/17.jpg)
Slide 17
CAPSULE
POLISHING
MACHINE
AUTO MATIC
CAPSULE
ARRANGEMNT
![Page 18: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/18.jpg)
Slide 18
Preparation of Soft Gelatin Capsules
Preparation of Soft Gelatin
Capsules
Plate process
Reciprocating die process
![Page 19: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/19.jpg)
Slide 19
Molds Filling with gelatin and medicament on bottom plate
Second sheet of gelatin is carefully placed on top of the
medication
Top plate of the mold is put into place
Pressure & heat is applied toseal the capsules
Washing
![Page 20: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/20.jpg)
Slide 20
![Page 21: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/21.jpg)
Slide 21
![Page 22: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/22.jpg)
Slide 22
References:-
• Pharmaceutical Dosage forms and Drug delivery Systems, Ansel’s, Chapter 7, Page 203-214, Ninth Edition, 2011, 2005 Wolters Kluwer / Lippincott Williams & Wilkins.
• Martin’s physical pharmacy and pharmaceutical sciences, Patrick J. Sinko, Chapter No.22, Page No. 580-581, Sixth Edition 2011, 2006 Lippincott Williams & Wilkins, Wolters Kluwer Business.
• Pharmaceutical preformulation and formulation , Mark Gibson, Page 451-453, 2004, Printed in USA, By Interpharm / CRC.
• Pharmaceutics The design and manufacture of Mediicines, Michael E.Aulton, Third Edition.
• Text book of Pharmaceutics, Bentley’s, Chapter 19 page 310-314, Eight Edition, Edited by: E.A.Rawlins, Published by A.I.T.B.S
![Page 23: Capsule 130802054344-phpapp02 sam](https://reader033.fdocuments.in/reader033/viewer/2022052623/559f557f1a28ab0a088b4605/html5/thumbnails/23.jpg)
Slide 23