Bulletin 34.3 New

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13-06-2014

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GGNNIIPPSSTT UULLLL TTIINN 22 1144

13th

June , 2014 Volume No.: 34 Issue No.: 03

Vision

O REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIOF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BASE

LEARNING AND PRACTICE

ontentsMessage from

PRINCIPAL

Editorial board

Historical article

News Update

Knowledge based Article

Disease Related

Breaking News

Upcoming Events

Drugs Update Campus News

Student’s Section

Editor’s Note

Archive

GNIPST Photo Gallery

or your comments/contribution

For ack-Issues,

ailto:[email protected]

GURU NANAK INSTITUTE OF PHARMACEUTICAL

SCIENCE AND TECHNOLOGY

Website: http://gnipst.ac.in

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mailto:[email protected]



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MESSAGE FROM PRINCIPAL

" It can happen. It does happen.

But it can't happen if you quit ." Lauren Dane.

‘We are what we repeatedly do.

Excellence then is not an act, but a habit .’ Aristotle

It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank the

last year’s editors and congratulate the newly selected editors for the current year.

Our first consideration is always in the best interest of the students. Our goal is to promote academicexcellence and continuous improvement.

I believe that excellence in education is aided by creating a learning environment in which all learners are

supported in maximizing their potential and talents. Education needs to focus on personalized learning

and instruction, while promoting an education system that is impartial, universally accessible, and meeting

the needs of all students.

It is of paramount importance that our learners have sufficient motivation and encouragement in order to

achieve their aims. We are all very proud of you, our students, and your accomplishments and look

forward to watching as you put your mark on the profession in the years ahead.

The call of the time is to progress, not merely to move ahead. Our progressive Management is looking

forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken in

this direction and fruits of these efforts will be received by our students in the near future. Our Teachers

are committed and dedicated for the development of the institution by imparting their knowledge and play

the role of facilitator as well as role model to our students.

The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positive

challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holistic

needs of our students.

I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of the

opportunities and meet the challenges with purpose and determination.

Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us on

this path.

My best wishes to all.

Dr. A. Sengupta

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EDITORIAL BOARD CHIEF EDITOR DR. ABHIJIT SENGUPTA

EDITOR MS. JEENATARA BEGUM

ASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE

HISTORICAL NOTES ON PHARMACY:The beginnings of pharmacy are ancient. When the first person

expressed juice from a succulent leaf to apply to a wound, this art

was being practiced. In the Greek legend, Asclepius, the god of thehealing art, delegated to Hygieia the duty of compounding his

remedies. She was his apothecaryor pharmacist. The physician-

priests of Egypt were divided into two classes: those who visited

the sick and those who remained in the temple and prepared

remedies for the patients.

In ancient Greece and Rome and during the Middle Ages in

Europe, the art of healing recognized a separation between the

duties of the physician and those of the herbalist, who suppliedthe physician with the raw materials from which to make

medicines. The Arabian influence in Europe during the 8th

century AD, however, brought about the practice of separate duties

for the pharmacist and physician. The trend toward specialization

was later reinforced by a law enacted by the city council of Bruges

in 1683, forbidding physicians to prepare medications for their

patients. In America, Benjamin Franklin took a pivotal step inkeeping the two professions separate when he appointed an

apothecary to the Pennsylvania Hospital. The development of

the pharmaceutical industry since World War II led to the

discovery and use of new and effective drug substances. It also

changed the role of the pharmacist. The scope for extemporaneous

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compounding of medicines was much diminished and with it the

need for the manipulative skills that were previously applied by

the pharmacist to the preparation of bougies, cachets, pills,

plasters, and potions. The pharmacist continues, however, to fulfillthe prescriber’s intentions by providing advice and information; by

formulating, storing, and providing correct dosage forms; and by

assuring the efficacy and quality of the dispensed or supplied

medicinal product.

The first college of pharmacy was founded in the United States in

1821 and is now known as the Philadelphia College of Pharmacy

and Science. Other institutes and colleges were established soon

after in the United States, Great Britain, and continental Europe.Colleges of pharmacy as independent organizations or as schools

of universities now operate in most developed countries of the

world.

NEWS UPDATE

'Tomato pill' improves function of blood vesselsin patients with cardiovascular disease:

(9th June, 2014)A daily supplement of an extract found in tomatoes may improvethe function of blood vessels in patients with cardiovasculardisease, according to new research. The incidence ofcardiovascular is notably where a 'Mediterranean diet' consistingof a larger consumption of fruit, vegetables and olive oil

predominates. Recent dietary studies suggest that this dietreduces the incidence of events related to the disease, includingheart attack and stroke, in patients at high cardiovascular risk, orthose who have previously had the disease. One component of theMediterranean diet thought to play a role in reducing this risk islycopene, a powerful antioxidant which is ten times more potent

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than vitamin E. Lycopene is found in tomatoes and other fruits,and its potency appears to be enhanced when it is consumedpureed, in ketchup or in the presence of olive oil. Whilst there isstrong epidemiological evidence to support the role of lycopene in

reducing cardiovascular risk, the mechanism by which it does so isunclear.

Human stem cells used to create light-sensitive

retina:(10th June,2014)

Like many processes in the body, vision depends on many different

types of cells working in concert, in this case to turn light intosomething that can be recognized by the brain as an image.

Photoreceptors are only part of the story in the complex eye-brain

process of vision. Using a type of human stem cell, researchers say

they have created a three-dimensional complement of human

retinal tissue in the laboratory, which notably includes

functioning photoreceptor cells capable of responding to light, the

first step in the process of converting it into visual images.

'Onion' vesicles for drug deliver developed:

(10th June, 2014)One of the defining features of cells is their membranes. Each cell'srepository of DNA and protein-making machinery must be keptstable and secure from invaders and toxins. Scientists haveattempted to replicate these properties, but, despite decades of

research, even the most basic membrane structures, known asvesicles, still face many problems when made in the lab. They aredifficult to make at consistent sizes and lack the stability of theirbiological counterparts.A certain kind of dendrimer, a moleculethat features tree-like branches, offers a simple way of creatingvesicles and tailoring their diameter and thickness, researchers

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report. Moreover, these dendrimer-based vesicles self-assemblewith concentric layers of membranes, much like an onion.

Malaria-carrying mosquitoes wiped out in lab

with genetic method that creates male-only

offspring: (10th June, 2014)Since 2000, increased prevention and control measures havereduced global malaria mortality rates by 42 per cent, but thedisease remains a prevalent killer especially in vulnerable sub-Saharan African regions. Malaria control has also been threatenedby the spread of insecticide resistant mosquitoes and malaria

parasites resistant to drugs. Scientists have modified mosquitoesto produce sperm that will only create males, pioneering a freshapproach to eradicating malaria. Since 2000, increased preventionand control measures have reduced global malaria mortality ratesby 42 per cent, but the disease remains a prevalent killer especiallyin vulnerable sub-Saharan African regions. Malaria control hasalso been threatened by the spread of insecticide resistantmosquitoes and malaria parasites resistant to drugs.

Limiting carbohydrates could reduce breastcancer recurrence in women with positive IGF1

receptor:(10th June, 2014)Receptors for IGF1 have been found in breast tumor tissue, andexpression of those receptors may contribute to treatmentresistance among breast cancer survivors. Since diet can influenceinsulin activation, the researchers wondered whether diet couldimpact breast cancer prognosis based on expression of the IGF1

receptor in the primary breast tumor tissue. Using an unusualapproach, this study assessed the combined association of twofactors implicated in tumor growth -- carbohydrate intake andIGF1 receptor status -- to test whether activating theinsulin/insulin-like growth-factor axis can impact breast cancer.Since carbohydrates stimulate the biological pathway that can

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increase concentrations of IGF1, the researchers focused oncarbohydrate intake.

'All systems go' for a paralyzed person to kick

off the World Cup: (10th June, 2014)All systems are go for a bold demonstration of neuroscience andcognitive technology in action: on June 12, during the opening ofthe FIFA 2014 World Cup in Brazil, a paralyzed person wearing abrain-controlled robotic exoskeleton is expected to make the firstkick. The system records electrical activity in the patient's brainand translates that to action. It also gives the patient tactilefeedback using sensitive artificial skin.

MRI shows brain abnormalities in late preterm

infants: (10th June, 2014)Babies born 32 to 36 weeks into gestation may have smaller brainsand other brain abnormalities that could lead to long-termdevelopmental problems, according to a new study. Researchersfocused on moderate and late preterm (MLPT) babies -- those

born between 32 weeks, zero days, and 36 weeks, six days, intogestation. MLPT babies account for approximately 80 percent ofall preterm births and are responsible for much of the rise in therates of preterm birth over the last 20 years.

Infection prevention implanted directly into

bones: (11th June,2014)

Hospital germs can be fatal, since they are resistant to antibiotics.As a result, alternative methods of defense against bacteria are in

demand. A research team has been able to develop bone implants

that keep the germs at bay. At first glance, the fine-grained

implant looks like flour. Only under the microscope can one see

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what is inside: The individual grains of the granules consist of

apatite crystals. These are similar in composition and structure to

natural bone material, which is formed of the same chemical

elements-calcium and phosphorus. The granules make it an ideal

material for implants. To prevent complications, some

manufacturers coat their bone substitute material with

antibiotics.

Mechanism explains complex brain wiring:

(11th June, 2014)It is estimated that a person has 100 billion neurons, or nerve cells.

These neurons have thin, elongated, highly branched offshootscalled dendrites and axons. They are the body's information andsignal processors. The dendrites receive electrical impulses fromthe other neurons and conduct these to the cell body. The cellbody then decides whether stimuli will or will not be transferredto other cells via the axon. A researcher unravels a part of themystery by describing a mechanism that explains novel aspects ofhow the wiring of highly branched neurons in the brain works.

These new insights into how complex neural networks are formedare very important for understanding and treating neurologicaldiseases.

For detail mail to editor

KNOWLEDGE BASED ARTICLE

PHARMACEUTICAL WATER:

Water is the most widely used substance, raw material or startingmaterial in the production, processing and formulation ofpharmaceutical products. It has unique chemical properties due toits polarity and hydrogen bonds. This means it is able to dissolve,

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absorb, adsorb or suspend many different compounds. Theseinclude contaminants that may represent hazards in themselves orthat may be able to react with intended product substances,resulting in hazards to health. Control of the quality of water

throughout the production, storage and distribution processes,including microbiological and chemical quality, is a major concern.Unlike other product and process ingredients, water is usuallydrawn from a system on demand, and is not subject to testing andbatch or lot release before use. Assurance of quality to meet theon-demand expectation is, therefore, essential. Additionally,certain microbiological tests may require periods of incubationand, therefore, the results are likely to lag behind the water use.

Different grades of water quality are required depending on theroute of administration of the pharmaceutical products. Othersources of guidance about different grades of water can be found inpharmacopoeias and related documents.

Drinking water:

Drinking-water should be supplied under continuous positivepressure in a plumbing system free of any defects that could lead

to contamination of any product. If drinking-water is used directlyin certain stages of pharmaceutical manufacture or is the feed-water for the production of higher qualities of WPU, then testingshould be carried out periodically by the water user’s site to con-firm that the quality meets the standards required for drinking-water.

Bulk Purified water:

Bulk purified water (BPW) should be prepared from a drinking-water source as a minimum-quality feed-water. It should meet therelevant pharmacopoeial specifications for chemical andmicrobiological purity with appropriate action and alert limits. Itshould also be protected from recontamination and microbial

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proliferation. BPW may be prepared by a combination of reverseosmosis (RO) RO/electro-deionization (EDI) and vapourcompression (VC). Alert levels for the water system should bedetermined from knowledge of the system and are not specified in

the pharmacopoeias.

Bulk Highly Purified water:Bulk highly purified water (BHPW) should be prepared fromdrinking water as a minimum-quality feed-water. BHPW is aunique specification for water found only in the EuropeanPharmacopoeia. This grade of water must meet the same qualitystandard as water for injections (WFI), including the limit for

endotoxins, but the water-treatment process used may bedifferent. Current production methods include, for example,double-pass RO coupled with othersuitable techniques such as ultrafiltration and deionization.BHPW may be prepared by a combination of different methodssuch as RO, ultrafiltration and deionization.

Bulk water for Injections:Bulk water for injections (BWFI) should be prepared from

drinking-water (usually with further treatment) or purified wateras a minimum-quality feedwater. BWFI is not sterile water and isnot a final dosage form. It is an intermediate bulk product andsuitable to be used as an ingredient during formulation. BWFI isthe highest quality of pharmacopoeial WPU. Certainpharmacopoeias place constraints upon the permitted puri-fication techniques as part of the specification of the BWFI. TheInternational Pharmacopoeia and the European Pharmacopoeia,

for example, allow only distillation as the final purification step.BWFI should meet the relevant pharmacopoeial specifications forchemical and microbiological purity (including endotoxin) withappropriate action andalert limits. BWFI should also be protected from recontaminationand microbial proliferation.

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Other Grades of water:When a specific process requires a special non-pharmacopoeialgrade of water, its specification must be documented within thecompany quality system. As a minimum it must meet the

pharmacopoeial requirements relating to the grade of WPUrequired for the type of dosage form or process step.

Maintenance of water systems:Water for Pharmaceutical Use or WPU systems should bemaintained in accordance with a controlled,documented maintenance programme that takes into account thefollowing:

– de"ned frequency for system elements;– the calibration programme;– SOPs for speci"c tasks;– control of approved spares;– issue of a clear maintenance plan and instructions;– review and approval of systems for use upon completion of work;– record and review of problems and faults during maintenance.Inspection of water system:WPU (BPW, BHPW and BWFI) systems are likely to be the

subject of regulatory inspection from time to time. Users shouldconsider conducting routine audit and self-inspection ofestablished water systems.This GMP guidance can be used as the basis of inspection. A tourof the water generation plant and visible pipework (including userpoints) should be performed to ensure that the system isappropriately designed, installed and maintained (e.g. that thereare no leaks and that the system matches the piping and

instrumentation diagram or drawing (P&ID).The following list identifies items and a logical sequence for aWPUsystem inspection or audit:– a current drawing of the water system showing all equipment inthe system from the inlet to the points of use along with sampling

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points and their designations;– approved piping drawings (e.g. orthographic and/or isometric);– a sampling and monitoring plan with a drawing of all samplepoints;

– training programme for sample collection and testing;– the setting of monitoring alert and action levels;– monitoring results and evaluation of trends;– inspection of the last annual system review;– review of any changes made to the system since the last auditanda check that the change control has been implemented;– review of deviations recorded and their investigation;

– general inspection of system for status and condition;– review of maintenance, failure and repair logs;– checking calibration and standardization of critical instruments.

DISEASE RELATED BREAKING NEWS

Middle East respiratory syndrome

coronavirus (11th

June, 2014)WHO encourages all Member States to continue theirsurveillance for acute respiratory infections. Infectionprevention and control measures are critical to prevent thepossible spread of MERS-CoV in health care facilities. It is notalways possible to identify patients with MERS-CoV earlybecause like other respiratory infections, the early symptoms ofMERS-CoV are non-specific. Therefore, health-care workers

should always apply standard precautions consistently with allpatients, regardless of their diagnosis. Droplet precautionsshould be added to the standard precautions when providingcare to patients with symptoms of acute respiratory infection;contact precautions and eye protection should be added whencaring for probable or confirmed cases of MERS-CoV infection;

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airborne precautions should be applied when performingaerosol generating procedures.Read more

UPCOMING EVENTS5th International Conference on Stem Cells and Cancer 2014, JNU

Convention Centre, New Delhi,India from 8-10 November.2014

DRUGS UPDATES

FDA Approves Bunavail Buccal Film for the

Maintenance Treatment of Opioid Dependence: (9th

June, 2014)

BUNAVAIL is the first and only formulation of buprenorphine andnaloxone for buccal (inside of the cheek) administration. Theability of BUNAVAIL to stick on the inside of the cheek, unlikesublingual products that need to be kept in place under the tongueuntil they dissolve, allows patients to talk, swallow and go about

normal daily activities while the medication is being consistentlyabsorbed. BioDelivery Sciences International, Inc. (BDSI)(NASDAQ: BDSI) received approval of the New Drug Application(NDA) for BUNAVAIL™ (buprenorphine and naloxone) buccalfilm (CIII) from the U.S. Food and Drug Administration (FDA).BUNAVAIL is indicated for the maintenance treatment of opioiddependence and should be used as part of a complete treatmentplan to include counseling and psychosocial support. BDSI

expects to launch BUNAVAIL late in the third quarter of 2014. Read more

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http://www.drugs.com/newdrugs/fda-approves-bunavail-buccal-film-maintenance-opioid-dependence-4047.html






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CAMPUS NEWS

Reminiscence, 2014(GNIPST Reunion) was held in College

campus on 2

nd

February,2014.

1st Annual Sports of GNIPST was held on 3rd February,2014 in

College campus ground.

An industrial tour and biodiversity tour was conducted in Sikkim

for B.Pharm and B.Sc. students under the supervision of Mr. Asis

Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.

B.Pharm 3rd year won the GNIPST Football Champions trophy,

2013. B.Pharm 3rd year won the final match 1-0 against B.Pharm 2nd

year. Deep Chakraborty was the only scorer of the final.

Students of GNIPST organized pre puja celebration programme,

‘Saaranya’ on 7th October, 2013 in college Auditorium.

GNIPST organized a garment distribution programme on 28th

September, 2013 at Dakshineswar Kali Temple and Adyapith,

Kolkata. On this remarkable event about hundred people have

received garments. More than hundred students and most of the

faculties participated on that day with lot of enthusiasm.

GNIPST celebrated World Heart Day (29

th

September) andPharmacist’s Day (25th September) on 25th and 26th September,

2013 in GNIPST Auditorium. A seminar on ‘Violence against

woman’ and ‘female foeticide’ was held on GNIPST Auditorium on

25th September organized by JABALA Action Research

Organization. On 26th September an intra-college Oral and Poster

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presentation competition related to World Pharmacist’s day and

Heart day was held in GNIPST. Ms. Purbali Chakraborty of

B.Pharm 4th year won the first prize in Oral Presentation. The

winner of Poster presentation was the group of Ms. Utsa Sinha,Mr. Koushik Saha and Mr. Niladri Banerjee (B.Pharm 4th year).

A good number of students have participated in both the

competition with their valuable views.

STUDENTS’ SECTION

WHO CAN ANSWER FIRST????

Who is the CEO of Dr Reddy’s Laboratories? Which pharmaceutical company recently

acquired a UK-based firm called CP

Pharmaceuticals? Answer of Previous Issue’s Questions

A) Fuleco B)Armadillo Identify the lady

Answer of Previous Issue’s Image

Sunderlal Bahuguna

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Congrts Mr. Subhadeep Sengupta for the correct

answers

Send your thoughts/

Quiz/Puzzles/games/write-ups or any other

contributions for Studen ts ’ Section answ ers

of this Section at [email protected]

EDITOR’S NOTE

I am proud to publish the 3rd

issue of 34th

Volume of GNIPST

BULLETIN. GNIPST BULLETIN now connected globally

through facebook account ‘GNIPST bulletin’

I want to convey my thanks to all the GNIPST members and the

readers for their valuable comments, encouragement and supports.

I am thankful to Dr. Abhijit Sengupta, Director of GNIPST forhis valuable advice and encouragement. Special thanks to Dr.

Prerona Saha, Mr. Debabrata Ghosh Dastidar for their kind co-

operation and technical supports. An important part of the

improvement of the bulletin is the contribution of the readers. You

are invited to send in your write ups, notes, critiques or any kind of

contribution for the forthcoming special and regular issue.

ARCHIVE

Teacher’s day was celebrated on 5th September, 2013 by the

students of GNIPST in GNIPST Auditorium.

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A zalea exotic flower ) , the fresher welcome programme for

newcomers of GNIPST in the session 2013-14 was held on 8th

August in GNIPST Auditorium.

One day seminar cum teachers’ development programme forschool teachers on the theme of “Recent Trends of Life Sciences

in Higher Education” organized by GNIPST held on 29th June,

2013 at GNIPST auditorium. The programme was inaugurated by

Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy

Director of JIS Group and Dr. Abhijit Sengupta, Director cum

Principal of GNIPST with lamp lighting. The programme started

with an opening song performed by the B.Pharm students of this

institute. The seminar consists of a series of lectures, video

presentations and poster session. On the pre lunch session 4

lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata

Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty

respectively. On their presentation the speakers enlighten the

recent development of Pharmacy, Genetics and Microbiology and

their correlation with Life Sciences. On the post lunch session, Ms.

Saini Setua and Ms. Sanchari Bhattacharjee explained the recentdevelopment and career opportunities in Biotechnology and

Hospital Management. The programme was concluded with

valedictory session and certificate distribution.

About 50 Higher secondary school teachers from different

schools of Kolkata and North& South 24 Parganas district of

West Bengal participated in this programme. A good interactive

session between participants and speakers was observed in theseminar. The seminar was a great success with the effort of

faculties, staffs and students of our Institute. It was a unique

discussion platform for school teachers and professional of the

emerging and newer branches of Life Science.

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The general body meeting of APTI, Bengal Branch has been

conducted at GNIPST on 15th June, 2012. The program started

with a nice presentation by Dr. Pulok Kr. Mukherjee, School ofNatural Products, JU on the skill to write a good manuscript for

publication in impact journals. It was followed by nearly two hour

long discussion among more than thirty participants on different

aspects of pharmacy education. Five nonmember participants

applied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT for

conducting the two years’ post graduate course (M.Pharm) inP H A R M A C O L O G Y . The approved number of seat is 18.

The number of seats in B.Pharm. has been increased from 60 to

120.

AICTE has sanctioned a release of grant under Research

Promotion Scheme (RPS) during the financial year 2012-13to

GNIPST as per the details below:a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical

Science & Technology.

b. Principal Investigator: Dr. LopamudraDutta.

c. Grant-in-aid sanctioned:Rs. 16,25000/- only

d. Approved duration: 3 years

e. Title of the project: Screening and identification of potential

medicinal plant of Purulia & Bankura districts of West Bengalwith respect to diseases such as diabetes, rheumatism, Jaundice,

hypertension and developing biotechnological tools for enhancing

bioactive molecules in these plants.

Bulletin 34.3 New

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