Clinical Pharmacokinetics and Pharmacodynamics Janice E. Sullivan, M.D. Brian Yarberry, Pharm.D.
Brian Sullivan, CSHB Executive Committee February 12, 2014 Brian Sullivan, CSHB Executive Committee...
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Transcript of Brian Sullivan, CSHB Executive Committee February 12, 2014 Brian Sullivan, CSHB Executive Committee...
Brian Sullivan, CSHB Executive CommitteeFebruary 12, 2014Brian Sullivan, CSHB Executive CommitteeFebruary 12, 2014
Genome Canada Webinar: PEDGenome Canada Webinar: PED
CSHB: Member Organizations
Canadian Pork Council: 4
Association of Swine Veterinarians: 1
Veterinary Colleges of Canada: 1
Canadian Centre for Swine Improvement: 1
Canadian Meat Council: 1
CCVO - CMVC
www.swinehealth.ca
General preparedness
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General preparedness
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General preparedness
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Canadian Swine Intelligence Network (CSHIN)
•
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Confirmed PED cases
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NIAGARA (1.0)
ELGIN (2.0)
Confirmed PED cases in CanadaSo far all in Ontario (13 herds, 10 counties)
PED specific strategies
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Strategies to prevent entry and spread of PED
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Strategies to prevent entry
• CSHB notified Canadian industry; developed technical bulletins & developed PED response templates (CCVO & CFIA)
• CASV partnership: biosecurity notices to transporters• Proper truck washing and disinfection protocols
communications• US collaboration (NPB): tracking PED developments and
monitoring targeted PED research• Sampling protocols and diagnostic capacity communications• CSHIN: monitoring PED-like reports; verifying that Canada
was PED free (until January 23)• Daily updates through CSHIN communications infrastructure
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Planned / proposed research
• CSHIN: Develop/implement advanced knowledge creation tools; design and implement effective reporting and data interrogation systems
• Funding under consideration by Alberta Livestock and Meat Agency (ALMA)
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Knowledge and Technology Transfer (KTT)
• PEDv related activities – transportation
• Comparison of what’s happening across the country
• Gap analysis
• Verification protocols
• Training of trainers
• Support from Agriculture and Agri-Food Canada and Canadian Pork Council
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Knowledge and Technology Transfer (KTT)
• Technical Advisory Group to address technical questions Clarity on new PED vaccine Implications of new strain of PED identified in US Potential contamination with feed as a vector
Small group with representation from key stakeholders Other expertise brought in as required Assessment of new knowledge and recommendations for
implementation Financial support requested from Agriculture and Agri-Food
Canada
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Environmental sampling for PED surveillance
• Lots of environmental surveillance happening provincially
• Proposal for national standardization and collaboration
• Monitoring results and communications through existing CSHIN infrastructure
• Under consideration by Agriculture and Agri-Food Canada
• Details under discussion with epidemiologists
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National PED communications capacity
• Collect, assess and share PED information from all industry stakeholders
• Currently being done ad hoc
• Support requested from Agriculture and Agri-Food Canada
• Requires industry support and involvement (two-way communication)
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Support to reduce the risk of spread from infected herds
• Provide support for additional costs to reduce the spread of infection from the first herds with PED
• Example of extra costs Stop animal movements Eventual controlled animal movements Special handling of culls and dead stock Additional veterinary services
• Options for support under consideration with Agriculture and Agri-Food Canada and provincial governments
Building a Healthier Herd – PVCRT 17
PED RESEARCH INITIATIVES (CURRENT)
• Hazard characterization (CFIA)
• Risk assessments completed (Quebec)
• Efficiency of disinfectants for PED on trucks
• Environmental sampling (Quebec, Ontario and now elsewhere)
• Vaccine development underway (Harris and others)
• Development of diagnostic tests on live animals
• Feed ingredient testing for PED (Ontario)
• Lots of effort, especially in Ontario, on adaptations for containment and preventing new breaks
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EXAMPLES OF PED RESEARCH REQUIRED INITIATIVES
• Risk of feed as a vector for PED transmission
• More general epidemiology research
• Efficacy of PED vaccines
• Development of effective diagnostic testing – antibodies
• And of course, genomics!
• CSHIN has a role in facilitating tracking results and sharing with the industry.
• Chris Byra and Lucie Verdon would be pleased to participate in further discussions.
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