Botox in MND · •Botox:Dysport 1:4 •Parotids •1ml anterior •0.5ml posterior...
Transcript of Botox in MND · •Botox:Dysport 1:4 •Parotids •1ml anterior •0.5ml posterior...
Botox in MND Ben Messer
NEAVS
December 2017
Contents
• Case studies
• Physiology/Pharmacology
• Training
• Technique
• Our numbers
• Evidence
Case Study
• 41m
• Recently diagnosed with respiratory failure post-PEG
• Cough Assist & NIV
• Sialorrhoea to the point of not being able to use NIV
• Glycopyrolate infusion
• Home with Botox to parotids locally
Case study
• 34m
• Tetraplegic with TV
• Regular attendance for botox • Parotids
Case study
• 57m
• Bulbar MND
• Cough Assist
• Submandibular and parotid botox
Physiology/Pharmacology
• 20-30% parotid
• 50-60% submandibular
• 10% sublingual
• 10% other
• Inhibition of ACh secretion
Training
Technique
Technique
Technique
• Dysport 300MU total • Diluted to 3mls
• Botox:Dysport 1:4
• Parotids • 1ml anterior
• 0.5ml posterior
• Submandibular & Parotids • 0.5mls into 6 sites
Newcastle numbers
• 23 MND patients since 2013 • 21 on the NEAVS programme
• 4 repeat injections
• 5 other patients
• 1 Bulbar dysfunction post Botox (DMD)
Newcastle numbers
• Variable outcomes • Symptomatic measurement
• 7/10 benefit
• Repeat when symptomatic • 3-6 months
• Usually continue anticholinergics
UK evidence
UK evidence
• Botox only used in 17/119 patients in 10 centres
• 14/17 third line
• 57% improvement
• 50% adverse effects • 2 bulbar impairment
International evidence
International evidence
• 10-145MU Dysport per parotid
• 80MU Dysport per Submandibular
• Small comparison study of USS Vs Landmark • 15 patients
• Better early symptom control with USS
International evidence
International evidence
• 50% Parotid
• 10% Submandibular
• 40% Both
Conclusions
• Limited but growing Newcastle experience
• Results consistent with UK data
• Bespoke approach
• Increasing numbers of requests for repeat injections