BLOOD. Learning Objectives Describe the primary functions' of blood Describe the characteristics of...
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Transcript of BLOOD. Learning Objectives Describe the primary functions' of blood Describe the characteristics of...
Learning Objectives
• Describe the primary functions' of blood
• Describe the characteristics of blood
• Discuss the blood types including Rh factor
• Describe common disorders of blood
Blood and Blood CellsBlood is a type of CONNECTIVE TISSUE
It has two basic components:
CELLS (rbc, wbc, platelets) = 45%
Plasma (water, proteins, amino acids..etc) = 55%
Hematocrit - volume of blood cells in a sample, should be 45%. The remaining fluid is plasma (55%). To determine the percentages, blood is placed in a centrifuge
Three Types of Blood Cells red blood cells (erythrocytes)white blood cells (leukocytes)platelets (thrombocytes)
BLOOD
RBC live about 4 months before going to the liver
Granular leukocytes live only a few days
Non-granular leukocyte 6 months or more
Biconcave discs5 million per cubic millimeterLack nuclei
HEMATOPOEISIS – formation of blood cells (bone marrow)
Liver & Spleen - phagocytosis
Main Functions of RBCs
Transports oxygen, picks up carbon dioxide
HEMOGLOBIN - molecule that combines with O2 IRON is critical to synthesize hemoglobin
Oxygen Levels
Oxyhemoglobin = plenty of oxygen; bright red
Deoxyhemoglobin = low in O2, “bluish red”
WHITE BLOOD CELLS(Leukocytes)
• General function is to protect the body against disease
• There are FIVE different kinds of WBCs
Granulocytes (granular cytoplasm) Neutrophils, Eosinophils, BasophilsAgranulocytes (lacking granular cytoplasm) Monocytes, Lymphocytes
Lymphocyte(nucleus is dark and takes up almost whole cell; almost no cytoplasm seen)
Defense against invaders
Yield Antibodies30% WBC
Platelets
• Platelets and blood clotting Platelets play an essential role in blood
clotting Blood clot formation
Clotting factors released at the injury site produce prothrombin activator
Prothrombin activator and calcium convert prothrombin to thrombin
Thrombin triggers formation of fibrin, which traps RBC to form a clot
PLASMA
The liquid portion of blood is 92% water
Also contains nutrients, gases, vitamins (etc) and plasma proteins
Plasma Proteins
• Albumins – blood pressure• Globulins (alpha, beta, gamma) – transport
lipids and antibodies for immunity• Fibrinogen – important for blood clotting
MAJOR EVENT IN BLOOD CLOTTING =
Fibrinogen converted to FIBRIN
HEMOSTASIS
The process of stopping bleedingInvolves the coagulation and clotting of the blood to seal the site of damage
1. Blood Vessel Spasm Seratonin = vasoconstrictor 2. Platelet plug formation 3. Blood coagulationconversion of fibrinogen to fibrin
*thrombin is an enzyme that causes the conversion
THREE EVENTS IN HEMOSTASIS
On a cold day in 1667, a renegade physician named Jean Denis transfused calf's blood into one of Paris's most notorious madmen. In doing so, Denis angered not only the elite scientists who had hoped to perform the first animal-to-human transfusions themselves, but also a host of powerful conservatives who believed that the doctor was toying with forces of nature that he did not understand. Just days after the experiment, the madman was dead, and Denis was framed for murder. From: Blood Work: A Tale of Medicine and Murder in the Scientific Revolution
Blood Type is Controlled by 3 Alleles
Alleles: A, B, O
A & B are codominant
O is recessive
4 Possible Blood Types
• Rh system Rh-positive blood
Rh factor antigen present in RBCs Rh-negative blood
No Rh factor present in RBCsNo anti-Rh antibodies present naturally in plasma
Anti-Rh antibodies appear in the plasma of Rh-negative people if Rh-positive RBCs have been introduced into their bodies
Blood that has antibodies on it that is not recognized by the body will be attacked by your immune system
O is the Universal Donor
AB is the Universal Acceptor
Rh Factor and Pregnancy
*Problem: When a fetus is Rh+ and the mother is Rh-, this can cause the mother’s immune system to attack the fetus. There are drugs that will suppress this reaction.
Blood Safety
EXAMPLES OF BLOODBORNE PATHOGENS • HEPATITIS B (HBV)• HEPATITIS C (HCV)• Other NON A, NON B HEPATITIS• HUMAN IMMUNODEFICIENCY VIRUS (HIV)• MALARIA• OTHER POTENTIALLY INFECTIOUS MATERIALS
TRANSMISSIONHIV, hepatitis B virus, and hepatitis C virus are the viruses most likely to be transmitted via the following routes in an occupational setting:
needle stick / sharps injuries skin or eye contact mucous membrane and non-intact skin exposure to contaminated blood or other potentially infectious materials ( scratches, cuts, bites, or wounds )
Avoid Contact With Blood
• Wear gloves• Dispose of items that have been
contaminated (tissues, needles, bandaids) in biohazard containers
• Do not “horse around”• Treat every person as if they may be
carrying an infectious disease
Carbon Monoxide Poisoning
CO binds to your hemoglobin, prevents oxygen from binding. Can be fatal. It is a "silent killer" as people often die in their sleep when a heater fails.
Carbon monoxide deaths are more likely to occur in winter Article from 2010, St Clair County
ANEMIA• Iron-Deficiency Anemia (most common)• Aplastic Anemia – bone marrow does not
produce enough RBC• Hemorrhagic anemia – due to extreme blood
loss• Pernicious anemia – B12 deficiency• Sickle Cell Anemia (genetic) -
blood cells abnormally shaped• Polycythemia – too many RBC
SICKLE CELL ANEMIA
• Genetic Disorder
• Abnormally shaped blood cells
• Parents can be carriers (asymptomatic)
Leukemia• Type of cancer• Overproduction of immature white blood
cells• They take the place of RBCs
• Treatable with bone marrow transplants, chemothemotherapy, radiation
Leukemia
• Leukopenia - Abnormally low WBC
• Leukocytosis – Abnormally high WBC count
• Leukemia – Elevated WBC, but they do not function properly – immature
Leukemia is one of the most common childhood cancers. It occurs when large numbers of abnormal white blood cells fill the bone marrow and sometimes enter the bloodstream.
Because these abnormal blood cells are defective, they don't help protect the body against infection the way normal white blood cells do. And because they grow uncontrollably, they take over the bone marrow and interfere with the body's production of other important types of cells in the bloodstream, like red blood cells (which carry oxygen) and platelets (which help blood to clot).
St. Jude Hospital
Infectious mononucleosis sometimes called "mono" or "the kissing disease," is an infection usually caused by the Epstein-Barr virus (EBV).
The designation "mononucleosis" refers to an increase in one type of white blood cells (lymphocytes) in the bloodstream relative to the other blood components as a result of the EBV infection.
EBV is very common, and many people have been exposed to the virus at some time in childhood.
Article at Medicinenet
Blood poisoning - Septicemia
• An infection enters the blood stream• Can be deadly• Treated with antibiotics
Thrombocytopenia
• Low production of Platelets• Causing bleeding or bruising
A bruise is caused when tiny blood vessels are damaged or broken as the result of a blow to the skin (be it bumping against something or hitting yourself with a hammer). The raised area of a bump or bruise results from blood leaking from these injured blood vessels into the tissues as well as from the body's response to the injury.
Hemophilia - inability or reduced ability of the blood to clot; genetic disorder (more on this later)
von Willebrand Disease - also a clotting disorder, but not as severe, excessive bruising occurs
HEMOPHILIA
This disorder causes a failure of the blood to clot
Patients can be treated with blood transfusions that include clotting agents.
Jaundice• In newborns, caused by the liver not
functioning fully• Secretes bilirubin into the blood causing
the yellow color• Exposure to flourescent lights (bili lights)
will break down the substance
Quick Genetics ReviewA gene consists of 2 alleles (represented by letters)One allele is usually dominant over the other Example: Genotype PhenotypePP widow’s peakPp widow’s peakpp straight hairline
A person with a widow's peak (Pp) is married to a person with a straight hairline (pp), what percentage of their children will have a straight hairline?
Two people who are both heterozygous for the widow's peak trait are married. What percentage of their children will have a straight hairline?
Sickle Cell Anemia is actually codominant
AA = normalAa = sickle cell trait (few symptoms)aa = sickle cell anemia
A female has sickle cell anemia and is married to a man who appears normal. A doctor tests the man and determines that he does NOT have sickle cell trait. What is the chance that this couple will have a child with sickle cell anemia?
Hemophilia is carried on the X chromosome
Females X H X H normal
X H X h carrier
X h X h hemophiliac
Males X H Y normal
X h Y hemophiliac