Biotechnology and Development in Singapore

Dr PHUA KAI HONGAssociate Professor ofHealth Policy and ManagementLee Kuan Yew School of Public Policy National University of Singapore

Introduction• Biotechnology in Singapore classified as

Biomedical Sciences (BMS) industry • Official statistics on biotechnology are disparate

except from the main publicly-funded agencies - Economic Development Board - BMS Group- Agency for Science, Technology & Research (A*STAR) - Biomedical Research Council

• Singapore Biomedical Researchers Database http://researchers.a-star.edu.sg maintained by Biomedical Research Council (BMRC) and Singapore Engineering Research Council (SERC)

• Directory of company profiles listed on BioSpacehttp://biospace.com

Four Pillars of Economic Growthin Singapore

• Trade • Tourism• Financial Services• Manufacturing

• Electronics• Information

technology• Chemicals• Life sciences

Vision of the Singapore Economic Development Board

To become a Global Medical Hub providing a comprehensive range

of world-class value-added Medical Services

Biomedical Sciences Cluster

Pharma Bulk Actives

Chemistry

GenomicsProteomics

Bioinformatics& IT

Transplantation Medicine

Complementary and Alternative Medicine

Nutritionals

PHARMACEUTICALS MEDICAL DEVICES

BIOTECHNOLOGYHEALTHCARE SERVICES

Fine Chemicals

Biomaterials

In vitro Diagnostics

Bio-Chip

Drug DeliveryContrast Media

Electromedical Devices

Diagnostic/ Therapeutic SystemsScientific & Analytical InstrumentsPharma Formulation

Specialty Chemicals

SupportingIndustry

Biopharmaceuticals

Bioengineering

Disposables & Supplies

Biologics/Vaccines

Medical ServicesLaboratory Services

E-HealthClinical Trial Services

Infocomms

Value Chain of Healthcare Services

Medical Services Laboratory Services

Clinical Trials

Telehealth/E-Health

Healthcare Services

Marketing

Regional HQManufacturing

& Production

Product &Process

DevelopmentBasic & Clinical

ResearchProduction & Manufacturing

Healthcare Delivery

Regional Hub

Marketing

VERTICAL & HORIZONTAL INTEGRATION

Singapore Government Initiatives for Biomedical/Life Sciences

• Ministerial Committee for Biomedical Sciences Industry

• International Advisory Council • $1 billion Biomedical Sciences

Investment Fund• Bioethics Advisory Committee• National Science & Technology Board restructured

into Agency for Science, Technology & Research (A*STAR)

• Biomedical Research Council to oversee R&D • Bio*One Capital – biomedical sciences capital

investment arm of Economic Development Board

Key Agencies for Biotechnology in Singapore

• EDB Biomedical Sciences Group (BMSG)- Responsible for investment promotion, industry planning and development

• EDB Bio*One CapitalSupports strategic investments in business spin-offs

• Agency for Science, Technology and Research (A*STAR)Biomedical Research Council (BMRC)- coordinates and funds R&D- grooms scientific leadership and talent

SingaporeMedicine –Promotion of Healthcare Services by the Singapore Tourism BoardEconomic Review Committee (ERC) 2003– recommendation targets of the

Health Services Working Group Aims:• Attract 1 million foreign patients with

I,000 daily admissions by 2012• Grow market share from 1% - 3% of GNP• Generate $3 billion in health expenditure

or $2.6 billion value-added to economy• Create 13, 000 new jobs

Foreign Patients in SingaporeYear 1992 1994 1996 1998 2000 2012

(planned) Number of foreign patients (public & private hospitals) 13,291 12,801 15,844 10,698 12,746 1,000,000?

Total no. of hospital admissions 214,657 235,650 272,186 270,048 306,880 % of foreign to total hospital admissions 6% 5% 6% 4% 4%

02000400060008000

10000120001400016000

1993 1994 1995 1996 1997 1998 1999 2000 2001 2002

Inpat ients

D ay surgery

Economic Intelligence Unit, Healthcare Asia Report

Top Healthcare Groups in AsiaCompany Country Sales

(US$m)Market Capitalization (US$million)

Bangkok Dusit Medical Thailand 36.3 15.1Raffles Medical Singapore 31.4 279.3

KPJ Healthcare Bhd Malaysia 28.3 40.8

Pantai Holdings Bhd Malaysia 30.1 186.3

Nichii Gakkan Japan 535.1 3,768.1Parkway Holdings Singapore 228.3 1,003.6Prasit Patana Thailand 51.5 0.6Bumrungrad Thailand 42.6 5.7

Samitivej Public Thailand 26.3 5.2

Biomedical Industry Promotion bythe Economic Development Board• By year 2010, EDB aims for Singapore to

be key business base for 15 world-class companies, and a regional centre for clinical trials and drug development. EDB has invested in R&D and HRD, and nurtured start-up companies through co-investments and venture capital.

• By 2008, 11 top pharma & biotech companies have invested in 25 plants

• 7 biomed plants will open in 2008-2010• Biologics will grow 13% annually• Biomedical industry will grow to over

$20 billion, employing 10,000 in 2010.

Share of Biomedical Industry in Manufacturing Sector

2007 1999 BMI Share Manu- BMI Share

(%) facturing (%)

Employment (No.) 11,518 338,885 5600 1.65

- Pharmaceutical 4,192- Medical Technology 7,325

Output (S$M) 24,000* 10.1 133.57 6.2 4.64

Value Added (S$M) 13,400* 24.4 34.92 5.2 14.89

Sources:Industry Statistics (2001, 2007) Economic Development Board, Singapore.Biomedical Sciences Factsheet 2008, EDB Singapore.

* Figures are in S$ million.

Growth of the Biomedical Industry in Singapore

2004 2005 2010 Target

Employment (No) 9200 >10,000 15,000

ManufacturingOutput 15.8 18 25(S$ billion)

Fixed Asset 849 860 Investment (S$ million))

Total Value Added 1.49 2.57 12.5(S$ billion)

Source: Economic Development Board, Singapore.

Investments in Biomedical Industry in Singapore

• Total venture capital $10.2 billion raised (1983-2000)

• $1 billion Biomedical Sciences Investments Fund (2000)

• $5 billion (2000-2005) total funds to$7 billion (2006-2010)

• Government venture capital fund –$20 million for R&D

• Wyeth-Ayerst plans US$300M plants (1999)

• Schering-Plough plans US$200M API plant and US$24M R&D Centre, and US$100M biotech plant (1999)

• Pfizer plans US$350M API plant (2000)• Biopolis R&D complex US$200M (2004)

Completed Investments in the Pharmaceutical Industry in Singapore

• 1971 Smith Kline Beecham US$118M API plant• 1979 Glaxo Wellcome US $147M API plant• 1990 Glaxo Wellcome US$153M API plant• 1993 Rhone-Poulenc Rover US$59M API plant• 1995 Glaxo Wellcome US$47M NPMD pilot plant• 1996 Schering-Plough US$118M API plant and

US$100M manufacturing plant• 1998 Rhone-Poulenc Rover US$41M API plant• 1999 Schering-Plough US$18M formulation facility

Aventis (formerly RPR) US35M API plant • 2001 Merck US$400M plant• 2003 Merck expanded US$100M plant• 2003 Pfizer US$350M API plant

(API- Active Product Ingredient)

Expenditure on R&D in SingaporeYEAR EXP (S$ million) GDP (S$ million) EXP/GDP (%)

2006 5,000 11,950,000 2.391981 81.00 31004.7 0.26

1990 571.70 67878.9 0.84

1991 756.80 75320.9 1.00

1992 949.50 80997.5 1.17

1993 998.20 94258.7 1.06

1994 1174.98 108224.0 1.09

1995 1366.55 120628.8 1.13

1996 1792.14 132629.3 1.35

1997 2104.00 141261.9 1.49

1998 2492.30 141216.2 1.76

1999 2656.40 143814.4 1.84

Sources: EDB (2006), National Science & Technology Board (1981-1990)

R&D in Biomedical Sciences Singapore, 2006

Private• S$531• 1,089 research

scientists• 286 PhDs (26.3%)• 226 MSc (20.8%)• 485 BSc (44.5%)

Public• S$277m• 934 research

scientists• 453 PhDs (48.5%)• 161 MSc (17.2%)• 318 BSc (34.0%)

Source: National Survey of R&D in Singapore, 2006, A*STAR

Biomedical/Life Sciences Training and Research Institutes in Singapore

• 1987 – Institute of Molecular & Cellular Biology (IMCB)• 1990 – Bioprocessing Technology Institute (BTI)• 1993 – Centre for National Products Research• 1996 – Bioinformatics Institute (BII)

– Lilly-NUS Centre for Clinical Pharmacology

• 1998 – Centre for Drug Evaluation• – Kent Ridge Digital Labs• 2000 – Johns Hopkins-NUH Centre

– Singapore Genomes Program (SGP)• 2001 – SGP renamed Genomes Institute of Singapore (GIS)

– Novartis Institute of Tropical Diseases• 2002 – Institute of Bioengineering and Nanotechnology (IBN)• 2003 – BioPolis hub for biomedical research• 2004 – Regional Emerging Disease Diseases Intervention Center

– Centre for Molecular Medicine• 2007 – Duke-NUS Graduate Medical School

Biomedical/Life Sciences in the National University of Singapore

• $30 million Office of Life Sciences• Main biomedical thrust on basic

mechanisms of human diseases - prevention and treatment

• Main activities – 1) education 2) research 3) training & recruitment

• New life sciences curriculum jointly launched by faculties of science and medicine in 2002

• Linkages with other institutes and centres• $100 million re-development of medical school

- renamed the Yong Loo Lin School of Medicine

Biomedical/Life Sciences Research in National University of Singapore• Coordinated research involving faculties of

medicine, science, engineering and computing; also law, arts & social sciences and business for ethical, legal, social and economic implications

• 5 target diseases – cancer, ageing/neurobiology, cardio-vascular, liver and infectious diseases

• 5 platform technologies – bioinformatics, bioengineering, experimental therapeutics, immunology and structural biology (genomics, proteomics, etc)

R&D Areas of Interest in the Biomedical Industry

• Genes, Genomes and Medicine- Human Genome - Molecular Breeding - Human Stem Cells

• Research to Business- Bioscience, Biotechnology - Global Biotech Investing

• Intellectual Property Rights- Publication, Research Products - Patent Laws, Licensing

• Emerging Technologies • Social & Ethical Issues

- Gene Testing- Whole Genome Scanning

Conclusion

• Strategic development of biotechnology building upon Singapore’s position as regional hub (trade, finance, services, etc)

• Integrated package of biotechnology development with biomedical industry –funding, regulations (IP protection), quality control, training & HRD, etc

• Proactive recruitment and management of international scientific talent

• Total systems approach with political will