“Between B Cells and T Cells: transcription factor EFB-1” And “Understanding the Effects of Genes On Human

Traits”

Daniela Marín Rivera

Medicine student

III SemesterMolecular Biology

Introduction

The transcription is the process responsable to

the sintesis of the molecular of RNA from the genetic information

contained in a DNA.

This point is important because the different s trancriptions factors

can to change the response on the cell.

Between B and T cells : transcription factor EBF-1 reminds who they are

Sciencedaily. July ,23 ,2013

The receptor EBF-1 was described previously by Rudolf Grosschedl and his colleagues were able to

prove as early as 1995, but its only significance level was immune cells

inactivation of T in his presence.

Between B and T cells : transcription factor EBF-1 reminds who they are

Sciencedaily, july,23,2013

Decided to use mice for further experiments on the mechanisms of this

transcription factor and took samples of mice in late phase of development and transferred to

mice lacking immune system and inactived the factor

transcription EFB-1

Image taken from:

http://www.bioblogia.com/2011/02/los-ratones-que-carecen-de-las-bacterias-normales-del-intestino-tienen-diferencias-en-el-desarrollo-cerebral-y-el-comportamiento/

.

Between B and T cells : transcription factor EBF-1 reminds who they are

Sciencedaily, July, 23,2013

After three months they managed to identify the presence of B cells in these mice but discovered they had forgotten their identity by the factor inactivation of transcription.

And in place of B cells were T cells and natural murderers, still

important this new finding, and considering it as a breakthrough in

order to control certain pathologies.

.

Between B and T cells : transcription factor EBF-1 reminds who they are

Sciencedaily, July, 23,2013

http://vivesana.blogspot.com/2013/03/documental-ruleta-genetica-el-juego-de.html

Knowing the activity of this transcription factor could be very useful because it can induce the cell to change identity and take

another route of action.

Image taken from :

PERSONAL OPINION

.

I believe this

discovery can be very

important in different

pathologies and long

term this new

knowledge allows cells

to be reprogrammed

as pathological loss of

specific types of cells.

http://edith-jules.blogspot.com/2011_02_01_archive.html

Image taken from :

Understanding the Effects of Genes On Human Traits

Sciencedaily, july, 31,2013

A new methodology for insight into the most common diseases in the human

would be a new way of developing medicine, and to understand the genetic

influences for such serious diseases locate an effective treatment for each

person.

Understanding the Effects of Genes On Human Traits

Sciencedaily, july, 31, 2013

The focus of this new methodology known as personalized medicine will be on the effects of disease-associated genomic variants on DNA-to-RNA transcription, instead of the challenging question of effects on RNA-to-

protein translation.

http://anestesiar.org/2010/citocromo-p450-cyp450-y-farmacogenetica/

Image taken from :

Understanding the Effects of Genes On Human Traits

Sciencedaily, july, 31, 2013

Thanks to this methodology, we can now better understand the effect of genetic variants on

translation of RNA to protein - a powerful way of developing biomarkers for personalized

medicine and new therapies.

Understanding the Effects of Genes On Human Traits

Sciencedaily, july, 31, 2013

Understanding the genome and their influence will be the objective of this

research there and generate appropriate treatments in diseases

affecting the majority of the population.

http://laterapiacelular.com/terapia-celular/

Image taken from :

PERSONAL OPINION

Personally feel that this methodology would be a

breakthrough and personalized medicine would be ideal for any

country, however the costs of studying any disease from the

genome would be very high and difficult to achieve but I think that the methodology would be very

useful and would be achieved control multiple common diseases

in the population.

.

The goal of medicine today is not supplying drugs that can produce damage to other

organs, the goal is to identify the problem from the genome and from there find

appropriate solutions.

The medical objective is to know the DNA of every person and to know that at one point influences is very important as transcription and interaction with transcription factors thus generating a variety of

possibilities for each person in their cure.

MEDICAL UTILITY

http://es.123rf.com/photo_11420525_las-palabras-curar-el-cancer-en-las-cadenas-de-adn-que-representan-la-importancia-de-la-investigacio.html

Image taken from :

Many studies related to the human genome genomic influences have shown many common complex diseases

such as asthma, diabetes, cancer or concerted ezquizofrenia and is indispensable as this variant affects

the health.

MEDICAL UTILITY

MEDICAL UTILITY

Both events have great medical importance both

differentiation of the immune system such as

knowledge of the genome and in the immune system for example could be the

cure for diseases of a type of cell and induce the system to

produce inactivated factor transcription

However, discovering a genetic variant predisposing

to a disease is only a first step. To apply this

knowledge towards prevention or

cure, including tailoring treatment to the patient's genetic profile, needs to know how this genetic variant affects health

BIBLIOGRAPHY

-Martínez S, Lina María. Biología Molecular. 7 ed. Medellín: UPB.

Facultad de Medicina, 2012. 78-84.P

-Robert Nechanitzky, Duygu Akbas, Stefanie Scherer, Ildiko

Györy, Thomas Hoyler, Senthilkumar Ramamoorthy, Andreas

Diefenbach, Rudolf Grosschedl. Transcription factor EBF1 is essential for

the maintenance of B cell identity and prevention of alternative fates in

committed cells. Nature Immunology, 2013.

-http://www.sciencedaily.com/releases/2013/07/130723113745.htm

-Quan Li, Angeliki Makri, Yang Lu, Luc Marchand, Rosemarie

Grabs, Marylene Rousseau, Houria Ounissi-Benkalha, Jerry

Pelletier, Francis Robert, Eef Harmsen, Thomas J. Hudson, Tomi

Pastinen, Constantin Polychronakos, Hui-Qi Qu.Genome-wide search for

exonic variants affecting translational efficiency. Nature

Communications, 2013; 4 DOI

-http://www.sciencedaily.com/releases/2013/07/130731164757.htm

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