ASP.NET Core 1.0: Understanding ASP.NET Core 1.0 (ASP.NET 5)
BIOLOGYYYYY 1.0
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Transcript of BIOLOGYYYYY 1.0
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BIOLOGYYYYY1.0
CET Reviewer
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LEVELS OF ORGANIZATIONS
BIOSPHERE BIOME ECOSYSTEM COMMUNITY POPULATION ORGANISM SYSTEMS ORGANS
TISSUES CELLS ORGANELLES ATOMS
Unicellular organisms – perform all life functions by themselves(Nutrition, respiration, movement, excretion, growth, sensitivity, reproduction)
Multicellular organisms – has individual cells that
perform specific functions
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Specialized plant cells– Root hair cell: increases water and nutrient absorption– Palisade cell: has lots of chloroplast increases the
absorption of light for photosynthesis– Epidermal: tightly packed, secretes a waxy cuticle
protects from excessive water lossSpecialized animal cells– Red blood cell: no nucleus = bi-concave shape increases
surface area: better oxygen absorption and transport– Sperm cell: with a movable tail; has lots of mitochondria
greater energy– Neuron: for interconnectivity/information transfer
through impulses sent throughout the body; has a myelin sheath that insulates the nerve fiber.
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ENZYMES too!
• “biological catalysts” = changes the rate of a reaction without the enzyme being changed itself
• Combine with molecules (substrates) enzyme-substrate complex
• Enzyme reactions:– Anabolic: building up larger molecules (synthetic
reaction)– Catabolic: breaking down smaller molecules
(degradative reaction)
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PHOTOSYNTHESIS• For autotrophs/producers: Light energy from the sun chemical
energy (glucose)
6CO2 + 6H2O C6H12O6 + O2
(Carbon dioxide + water Glucose + Oxygen)
• Parts:1. Light reaction: dependent on light; in the photosystems of
the thylakoid • Light energy Water oxidized to oxygen Energy: ATP and
NADPH2
2. Dark reaction (Calvin Cycle): dependent on temperature; in the stroma• ATP and NADPH2 reduce CO2 reduced carbon =
organic carbon (Glucose)
Light energy
Chlorphyll
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Quick terms!
ATP = Adenosine triphosphate
NADPH2 = Nicotinamide adenine dinucleotide phosphate
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The Chloroplast
Chlorophyll:– Absorbs red, violet and blue; reflects green– Most abundant forms: chlorophyll a and b– Embedded in the thylakoid
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CELLULAR RESPIRATION• Sugars/carbohydrates + Oxygen ENERGY, water and carbon
dioxide
C6H12O6 + O2 6CO2 + 6H2O + Energy
• Parts: 1. Glycolosis: cytoplasm, no oxygen; glucose pyruvate2. Kreb’s Cycle/Citric Acid Cycle: inside the mitochondria; needs
oxygen
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HOMEOSTASIS• Organism maintaining constant internal conditions
necessary for life• Cell and molecular physiology: – diffusion, osmosis, passive transport, active transport
• System/organ physiology: (body temp = 37/98.6 F; hypothalamus =
thermostat)– Endocrine system– Thermoregulation • skeletal muscles = shivering, • non-shivering thermogenesis: decomposing of fat
heat; sweating
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–Chemical regulation • Pancreas: insulin and glucagon for
lower blood-sugar concentration• Lungs: CO2 O2; • kidneys: remove urea, adjusts the
concentration of water and ions)• Organism/ecological physiology:
Adaptation– genes change phenotypes change–extended phenotypes– reverse engineering
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CELLULAR BIOLOGY• CELL THEORY: proposed by Matthias
Jakob Schleiden and Theodor Schwann–All organisms are composed of one or more
cells.–A cell is the organism’s basic unit of
structure and function.–All cells come from previously existing
cells.– The continuity of life is based on inheritable
information in the form of DNA.
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TYPES OF CELLSPROKARYOTES• DNA region: nucleoid• No organelles, except
ribosomes• Locomotion (common)• Eubacteria,
Archaebacteria, Halophiles, Methanogens, Thermophiles
EUKARYOTES• With distinct nucleus• With organelles• Only some have
locomotion parts• Protoctista (Protists),
Fungi, Plantae, Animalia
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PROKARYOTIC CELL
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EUKARYOTIC
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EUKARYOTIC
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MAIN REGION: Nucleus• control center of the cell
• contains DNAPARTS FUNCTIONS
nuclear membrane selectively permeable lipid bi-layer encloses the nucleoplasm
nucleoplasm jelly-like fluid where the nucleoli and chromatin are suspended
nucleolus/nucleoli small bodies in the nucleus where ribosomes are assembled
chromatin loose network of DNA and proteins
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MAIN REGION: Plasma Membrane• contains the cell contents and separates them
PARTS FUNCTIONS
tight junctions impermeable junctions; binds cells together into leak proof sheets
desmosomes anchoring junctions; prevents cells from being pulled apart
gap junctionscommunication junctions;
neighboring cells connected by connexons
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MAIN REGION: Cytoplasm• cellular material outside the nucleus and inside
the plasma• site of most cellular activities
PARTS FUNCTIONS
cytosol semi-transparent liquid where organelles are suspended
inclusions non-functioning units of the cell (e.g. stored nutrients/products)
organelles metabolic machinery of the cell
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MAJOR ORGANELLES WITHIN THE CYTOPLASM
• Golgi Apparatus– “traffic conductor” for cellular proteins– functions in modifying and packaging of proteins– sends out proteins for export via secretory vesicles
• Lysosome– “breakdown bodies”– contains hydrolytic enzymes that break down
proteins, carbohydrates, and lipids– also digests disease-causing bacteria
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• Peroxisome– membrane sacs containing powerful oxidase enzymes– disarms dangerous free radicals by converting them
to hyrdogen peroxide• Centrioles– rod-shaped bodies– direct the formation of mitotic spindle
• Cytoskeleton– cell‘s “bones and muscles– provides an internal framework
MAJOR ORGANELLES WITHIN THE CYTOPLASM
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• Rough Endoplasmic Reticulum– studded with
ribosomes– where proteins from
ribosomes assume their functional shapes
– sends proteins to the GA via transport vesicles
• Smooth Endoplasmic Reticulum– continuation of the
rough ER– functions in
cholesterol synthesis and fat metabolism
– detoxification of drugs
MAJOR ORGANELLES WITHIN THE CYTOPLASM
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CELLULAR REPRODUCTIONASEXUAL SEXUAL
one parent two parents (common)Budding: plant embryonic shoot HermaphroditesFission: bacteria, paramecium,
euglena, planariahaploid gametes combine
to form diploid zygotes
Fragmentation: liverworts, sea stars
Spore formation: fungiVegetative reproduction: stolons (strawberry), tubers (potatoes),
bulbs (garlic)
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CELLULAR DIVISION: Mitosis• occurs in animals and plants for growth
and repair• results in 2 identical, diploid, daughter
cells• basis for asexual reproduction in
unicellular organisms, allowing rapid population growth
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CELLULAR DIVISION: MitosisTERMS DEFINITION
chromatin uncoiled DNA statechromosome coiled state, duplicate copies
chromatid single copy of the genetic materialcentromere center of chromatidskinetochore point where centromeres are attached
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MITOSIS: Interphase• period between mitosis and
meiosis• divided into 3 sub phases: –G1
• preparation for chromosome or DNA replication
–S• DNA replication
–G2• preparation for mitosis or
meiosis
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MITOSIS: Prophase
• centrosomes form spindle poles
• spindle fibers begin to form and are organized
• nuclear envelope disintegrates
• nucleolus disappears
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MITOSIS: Metaphase
• chromosomes move to equator or metaphase plate
• sister centromeres become attached to spindle fibers from opposite poles
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MITOSIS: Anaphase
• starts when kinetochores separate and chromatids move to opposite poles of the cell
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MITOSIS: Telophase
• chromatids reach the poles of the cell
• nuclear envelope forms
• nucleolus reappears
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CELLULAR DIVISION: Meiosis• results in four haploid, daughter cells• basis for gamete production in sexual
reproduction• as it results in halving of the chromosome
number, meiosis is also called reduction divisionTERMS DEFINITION
tetrad homologous chromosome joined together in a process called synapsis
crossing-overexchange of genetic material between homologous
chromosomescontributes to variability and diversity of organisms
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CELLULAR DIVISION: Meiosis
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MEIOSIS: Interphase
• “resting stage”• chromosomes are
very long and thin
• towards the end, chromosomes have already made replica chromatids joined by centromeres
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MEIOSIS: Prophase I
• nuclear envelope disintegrates
• nucleolus disappears• tetrads form• crossing-over occurs
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MEIOSIS: Metaphase I
• after crossing-over, homologous chromosomes move to the equator of the cell
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MEIOSIS: Anaphase I
• homologous chromosomes start to separate and move to opposite poles
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MEIOSIS: Telophase I
• cell divides into two daughter cells
• nuclear envelope develops
• marks the end of the first phase of meiotic division
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MEIOSIS II• division of two daughter cells
from meiosis I• similar to mitosis but there is
no replication of chromosomes• results in 4 cells which are
haploid
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CELLULAR DIVISION
MITOSIS MEIOSIS1 diploid
mother cell, 2 diploid
daughter cells
1 diploid parent cell, 4
haploid daughter cells
for growth and development of organism from zygote
production of gametes
for asexual reproduction in
cellular organisms
adds to genetic variability
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MOLECULAR BIOLOGY• seeks to understand the molecular basis of life –
particular it relates the structure of specific molecules of biological importance to their functional role in the intact cell and organism
Genetic Code• Degenerate – many combinations correspond to a
single amino acid• Wobble position – position in the code that varies
BASE PAIRING (DNA)Adenine – ThymineGuanine – Cytosine
BASE PAIRING (RNA)Adenine – UracilGuanine – Cytosine
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THE CENTRAL DOGMA
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THE CENTRAL DOGMA1. REPLICATION– semi-conservative process – daughter cells would
contain one strand of the parent DNA and one strand of the new DNA
– occurs in the nucleus2. TRANSLATION– process where DNA is copied into a single
stranded RNA– occurs in the nucleus– product mRNA moves to cytoplasm
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THE CENTRAL DOGMA3. TRANSLATION– occurs in ribosomes where mRNA is translated
into proteins– governed by the genetic code which combination
of three bases or triplet directs the addition of a particular amino acid to the growing protein chain
– Start and Stop Codons signals start and end of translation
** Start codons: AUG (methionine)Stop codons: UAG, UGA, UAA
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GENETICS• Study of heredity (by Gregor Mendel) Mendelian Laws of Genetics and Non-Mendelian genetics• TERMS:
– Genotype: genetic make-up– Phenotype: observable properties/manifestation of genes– Allele: different forms of the gene– Dominant: property appears in heterozygous (Y)– Recessive: property masked in heterozygous (y)– Pure breeding: homozygous + homozygous breeding– Homologous chromosomes: chromosome pairs; same length and
same traits– Homozygous alleles: 2 identical alleles (YY, yy)– Heterozygous alleles: 2 different alleles (Yy)
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MENDELIAN GENETICS• Characteristics are passed on from one generation to the
next by genes (factors)• Factors (genes) come in pairs (alleles)• Principles:– Principle of Segregation: Gene pairs separate during
gamete formation (PP x pp)– Principle of Independent Assortment: a
representative allele is present in the gametes (PpRr x PPrr) *dominant > recessive
• Sex-related inheritance:– Hemophilia & color-blindness (X-linked recessive)– Sex-influenced baldness
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Non-Mendelian Genetics• Incomplete dominance: phenotypes in between the parental
varieties– Ie: Red x White = Pink
• Codominance: (in heterozygotes) Both alleles are expressed– Like: ABO blood groups (AB = AB type)
• Pleiotropy: 1 gene controlling more than one phenotypic trait• Polygenic Inheritance: many different genes control one
phenotypic trait (intelligence, skin color, height)• Lethal allele combination: alleles on come loci (locations)
skewed offspring ratios/missing offspring types