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Transcript of biology, basic
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Pharmacological Targets in Schizophrenia
Dopamine
Adapted from Kandel et al., eds. Principles of Neural Science. Norwalk, CT: Appleton & Lange; 1991:854.
Hypoactivity: Negativeand Cognitive Symptoms
Hyperactivity:Positive Symptoms
Tuberoinfundibular Pathway
MesocorticalPathway
MesolimbicPathway
NigrostriatalPathway
Dopaminergic Pathways in the Brain
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Schizophrenia Core Symptoms
Psychotic Deficit Cognitive
PositiveSymptomsMesolimbic pathway
NegativeSymptomsDLPC &VMPFC
CognitiveDysfunctionDLPFC
AffectiveVMPFC
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Smith et al (1997)
Synthesis and degradation of serotonin
Tryptophan
5-Hydroxytryptophan (5-HTP)
Tryptophan hydroxylase
5-Hydroxytryptamine (5-HT)
5-Hydroxytryptophan decarboxylase
5-Hydroxyindolacetic acid (5-HIAA)
Monoamine oxidase (MAO)
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Synthesis and degradation of catecholamines
PhenylalanineKey
COMT = Catechol O-methyltransferase
MAO = Monoamineoxidase
L-tyrosine
Dopamine
L-dopa
Tyrosine hydroxylase
3-methoxy-tyramine Noradrenaline3,4-dihydroxyphenylacetic acid (DOPAC)
Homovalinillic acid (HVA)
3-methoxy-4-hydroxy phenylglycol (MHPG)
3-methoxy-4-hydroxy mandelic acid (VMA))
COMT MAO MAO/COMT
Roth et al (1995)