BIOKIMIA ENDOKRIN

dr.Syazili Mustofa.

Departemen Biokimia Kedokteran

UNIVERSITAS LAMPUNG

Kenapa penting??

Dasar untuk mempelajari penyakit gangguan endokrin.

Gangguan endokrin yang sering ditemui adalah:

Diabetes melitusHipertiroidisme

Mechanism of Hormone Action• Hormones are carried by the blood, yet they affect only

certain cells. The specific cells that respond to a given hormone have receptor sites for that hormone.

• Receptor sites may be located on the surface of the cell membrane or in the interior of the cell.

SISTEM HORMON

Hormon = membangkitkan aktivitas Hormon oleh jar. → sistem sirkulasi → jar. Lain Parakrin → organ sama jaringan berbeda Autokrin →organ dan jaringan yg sama

Hormon dapat ditargetkan pada lebih dari satu jaringan .

Kelenjar target: ± 200 tipe sel tubuh ± 50 hormon yang sudah dikenal

Reseptor Hormon

Ada dua macam reseptor hormon:1.Reseptor yang mengikat hormon di luar sel.

Hormon polipeptida, protein, dan katekolamin terikat reseptor pada membran plasma → menyalur fungsi ke intrasel melalui aktivitas enzim adenilil siklase cAMP dan fosfolipase C Ca++

2.Reseptor yang mengikat hormon intraselluler Hormon Steroid dan Tiroid, Transkripsi

Mechanism of Hormone Action

• Protein hormones, in general, are water soluble and are unable to diffuse through the cell membrane and react with receptor sites on the surface of the cell.

• Steroids are fat soluble and can diffuse through the cell membrane and react with receptors inside the cell.

Mechanism of Hormone Action

Mechanism of Hormone Action

HORMON RESEPTOR MEMBRAN;- ACTH- ADH- FSH- hcG- LIPOPROTEIN = LPH- LUTEINISASI = LH- TSH- PARATIROID (PTH)- GLUKAGON- INSULIN - ADRENALIN DAN NOR ADRENALIN

Mechanism of steroid Hormone Action

Mechanism of steroid Hormone Action

HORMON RESEPTOR INTRASEL:

- ESTROGEN- GLUKOKORTIKOID- MINERALOKORTIKOID- PROGESTIN- KALSITRIOL- ANDROGEN- TIROID = T4;T3