Bioinorganic Chemistry: Role of Metals in Biology · Edith V. Bowers, Geoffrey S. Murphy, Stephanie...
Transcript of Bioinorganic Chemistry: Role of Metals in Biology · Edith V. Bowers, Geoffrey S. Murphy, Stephanie...
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Bioinorganic Chemistry:
Role of Metals in Biology
Deborah C. Bebout
Chemistry Department
The College of William & Mary
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Dark green: high mass percent
Light green: trace required by all
Pale green: trace required by some
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I the 1%
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Metallobiome Structure
vs.
Function
Toxicology
Synthetic
Models
Bioinorganic Chemistry
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Zn
Cd
Hg
0.003 mass %; Essential to all known life forms
Thalassiosira weissflogii produces Cd(II)-dependent
carbonic anhydrase in Zn(II) limiting conditions
…or not IIB
…but generally considered toxic to all known life forms
Broad toxicity of Hg(II) likely precludes any
physiologically beneficial role
…LD50 (ZnCl2) 350 mg/kg, rat (oral)
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New
InsightNMRX-Ray
ESI-MS
>60 new
complexes
Slow exchange
J(199Hg1H)
J(111/113Cd1H)
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Julie A. Viehweg, Sarah M. Stamps, Jennifer J. Dertinger, Robert L. Green, Katherine E. Harris,
Raymond J. Butcher, ‡ Erica J. Andriole, J.C. Poutsma, Steven M. Berry, Deborah C. Bebout*
“A Synthetic Model of Hg(II) Sequestration” Dalton Transactions 2010, 39, 3174.
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Malia S. Hain, Yoko Fukuda, Carolina Rojas Ramírez, Benjamin Y. Winer, Stephanie E. Winslow, Robert D. Pike,
and Deborah C. Bebout* “Staging Bonding between Group 12 Metal Ions and Neutral Selenium Donors: Intermolecular
Interactions of Mixed N,Se Donor Ligands and Anions” Crystal Growth & Design 2014, 14, 6497−6507.
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Edith V. Bowers, Geoffrey S. Murphy, Stephanie N. Till, Christopher J. VandenBussche, Melissa M. Yaroschak,
Robert D. Pike, Raymond J. Butcher‡ and Deborah C. Bebout* “Bis-tetradentate Complexes of Cd(II) and Hg(II) with N8
Coordination: Structural and NMR Comparisons of Tripodal Amine Ligands with Pyridyl and Imidazoyl Groups” Dalton
Trans. 2014, 43, 16475–16485.
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Organic synthesis
Purification
Coordination Chem
Routine NMR
IR, UV/Vis, etc.
Multinuclear NMR
ESI-MS
X-ray Crystallography
Scientific writing
Scientific presentations
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Three juniors now;
prefer sophomores
& freshman
Please come talk
to me if interested!
ISC 2039 & 2028
I’M A HEAVY
METAL FAN.ME TOO!