Bioengineering Approaches for Regenerating Organs and Fighting Cancer
29
Bioengineering Approaches for Regenerating Organs and Fighting Cancer Erik Reinertsen UCLA Bioengineering Friday, March 9, 12
-
Upload
erik-reinertsen -
Category
Technology
-
view
416 -
download
5
description
I will present a basic overview of biomaterials for 1) tissue engineering and 2) cancer therapeutics.
Transcript of Bioengineering Approaches for Regenerating Organs and Fighting Cancer
Bioengineering Approaches for Regenerating Organs and Fighting Cancer
Erik ReinertsenUCLA Bioengineering
Friday, March 9, 12
Three topics
1. The father of biomaterials2. Tissue engineering3. Cancer therapeutics
Friday, March 9, 12
Gliadel
Friday, March 9, 12
Three topics
1. The father of biomaterials2. Tissue engineering3. Cancer therapeutics
Friday, March 9, 12
Engineering tissues & organs
Friday, March 9, 12
Engineering tissues & organs
Langer R, Vacanti K. Science (1993)Friday, March 9, 12
Tissue engineering could address organ shortages
www.mdconsult.comFriday, March 9, 12
In vivo-like platforms for pharmaceutical testing
Friday, March 9, 12
Huge potential in tissue engineering + stem cells
www.mdconsult.comFriday, March 9, 12
Stem cell therapies could help millions of patients
Perry D. Science (2000)
0 20 40 60
Other
Parkinson's disease
Alzheimer's disease
Cancer
Osteoporosis
Diabetes
Autoimmune diseases
Cardiovascular diseases
Millions of people
Friday, March 9, 12
Scaffolds engineered from biocompatible polymers
1. www.techno-isel.com2. Wu Lab, UCLA Department of Bioengineering 3. www.pharmainfo.net
PCL2PLGA1 Collagen3
Friday, March 9, 12
Lutolf M., Hubbell J. Nature Biotechnology (2005)
Biochemical signals
Friday, March 9, 12
Engler A. Cell (2006)
Physical signals
MSC morphology changes with elasticity
Friday, March 9, 12
5 mg/mL 10 mg/mL 20 mg/mL
Day
1
Day
4
Day
7
500 um 500 um 1 mm
500 um 500 um 500 um
500 um 500 um 500 um
Fibroblasts spread more in lower fibrin concentration
Reinertsen E., Tawil B., Wu B.M. Tissue Engineering (submitted)Friday, March 9, 12
Cell viability is limited by oxygen transport
Demol et al. Biomaterials (2010)Friday, March 9, 12
3D printing offers novel methods of shape control
Friday, March 9, 12
Three topics
1. The father of biomaterials2. Tissue engineering3. Cancer therapeutics
Friday, March 9, 12
Cancer is the #1 killer in the world
www.tgrbio.comFriday, March 9, 12
Cancer is the #1 killer in the world
www.who.int/mediawww.cdc.gov/nchs/fastats/lcod.htm
Worldwide-7.6 million deaths
In the US alone-1.5 million cases-600,000 deaths
Friday, March 9, 12
Hanahan D., Weinberg R. Cell (2011)
Six hallmarks of cancer
Friday, March 9, 12
en.wikipedia.org/wiki/Doxorubicinwww.rikenresearch.riken.jp
Current cancer therapeutics are limited
Chemotherapy Antibodies Surgery
Friday, March 9, 12
Low K.H. et al. Rapid Prototyping Journal (2007)
Controlled drug release reduces nonspecific effects
Friday, March 9, 12
www.medscape.com/viewarticle/723827_4
Biomolecular targeting for cancer therapeutics
Friday, March 9, 12
Enhanced permeability and retention (EPR) effect
Macromolecules and particles between 60-400 nm accumulate in tumors
www.nature.com/nrd/journal/v2/n5/images/nrd1088-f3.gifD. P. O’Neal et al. Cancer Letters (2004)Friday, March 9, 12
1. Stem cells2. Complex organs3. siRNA / genetics
The future of biomaterials
Friday, March 9, 12
Biomaterials is a highly multidisciplinary field
Cell biology
Materials sciencePhysics
BiochemistryMedicine
Friday, March 9, 12
More (free) resources
PLoSTED talksiTunes U@erikreinertsen
Friday, March 9, 12
Acknowledgements
Benjamin Wu, DDS, PhDBill Tawil, PhDDaniel Kamei, PhDAmy Chung, PhDMin Lee, PhDJun Kim
Friday, March 9, 12
