Regenerating Damaged Bones and Joints
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Trinity Centre for Bioengineering Regenerating Damaged Bones and Joints Prof. Daniel J. Kelly Dept of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Ireland. Trinity Centre for Bioengineering, Trinity Biomedical Science Institute, Trinity College Dublin, Ireland. AMBER (Advanced Materials and Bioengineering Research Centre), Trinity College Dublin, Ireland.
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Transcript of Regenerating Damaged Bones and Joints
- 1. Trinity Centre for Bioengineering Regenerating Damaged Bones and Joints Prof. Daniel J. Kelly Dept of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Ireland. Trinity Centre for Bioengineering, Trinity Biomedical Science Institute, Trinity College Dublin, Ireland. AMBER (Advanced Materials and Bioengineering Research Centre), Trinity College Dublin, Ireland.
- 2. Trinity Centre for Bioengineering Research Interests: Mechanobiology How do adult stem cells respond to biophysical cues? Tissue Engineering and Regenerative Medicine Adult Stem Cell / Biomaterial based therapies for musculoskeletal tissue regeneration. Funding: European Research Council Starter Grant (1.5m)/Consolidator Grant (2m) SFI PIYRA (1.3m) / IvP Award (1.7m) / SFI US Ireland Fund AO Foundation; Enterprise Ireland; Irish Research Council. Lab Overview
- 3. Trinity Centre for Bioengineering Core technologies/expertise Hydrogels for tissue regeneration Mesenchymal stem cells (esp. Infrapatellar fat pad) ECM derived scaffolds Bioreactors Electrospinning 3D Bioprinting Application areas Focal cartilage & osteochondral defect repair Large bone defect healing Whole bone and joint regeneration Ligament regeneration Interface tissue engineering Lab Overview
- 4. Trinity Centre for Bioengineering Osteoarthritis A major clinical problem Adopted from Aigner et al. (2006)
- 5. Trinity Centre for Bioengineering Whole Bone and Joint Regeneration Thompson et al, 2015
- 6. Trinity Centre for Bioengineering Mesenchymal Stem Cells (MSCs) Adapted from Caplan (1989; 1994)
- 7. Trinity Centre for Bioengineering Endochondral Bone Tissue Engineering Sheehy et al, Acta Biomaterilia, 2015.
- 8. Trinity Centre for Bioengineering Endochondral Bone Tissue Engineering Sheehy et al, 2015.
- 9. Trinity Centre for Bioengineering 100m Enhanced Bone Formation In-Vivo 2. PCL Deposition 3. MSC laden Alginate Deposition 4. Hybrid Scaffold Channelled Hybrid Scaffold 1. Stem Cell Expansion 3D Bioprinting For Endochondral Bone Regeneration
- 10. Trinity Centre for Bioengineering 3D Bioprinting For Endochondral Bone Regeneration
- 11. Trinity Centre for Bioengineering Whole Bone Regeneration Sheehy et al, Bioresearch Open Access, 2015.
- 12. Trinity Centre for Bioengineering Whole Bone Regeneration Sheehy et al, Bioresearch Open Access, 2015.
- 13. Trinity Centre for Bioengineering Joint Regeneration
- 14. Trinity Centre for Bioengineering Joint Regeneration
- 15. Trinity Centre for Bioengineering Current lab members: Dr Grainne Cunniffe Dr Binulal Sathy Dr John Mulvihill Dr Sara Romanazzo Dr David Browe Simon Carroll Lu Luo Henrique Almeida Adam OReilly Alan Irvine Susan Critchley Rukmani Sridharan Andrew Daly Tomas Gonzalez Fernandez Pedro Daz Payno Dinorath Olvera Paola Aprile Johnnie Chu Acknowledgements Funding: Science Foundation Ireland (President of Ireland Young Researcher Award, Research Frontiers Programme) European Research Council Enterprise Ireland Irish Research Council Past lab members: Dr Conor Buckley Dr Eric Meyer Dr Mathew Haugh Dr Yurong Liu Dr Rajalakshmanan Eswaramoorthy Dr Michael Sawkins Dr Tariq Mesallati Dr Alanna Gannon Dr Eamon Sheehy Dr Andrew Steward Dr Darren Burke Dr Thomas Nagel Dr Stephen Thorpe Dr Eoghan Maher Dr Tatiana Vinardel Dr Michael Early Edoardo DellAmico Peter Kearney Collaborators: Prof. Fergal OBrien (Royal College of Surgeons in Ireland) Prof Cathal Moran (Trinity College Dublin) Prof. Veronica Campbell (Trinity College Dublin) Prof. Paula Murphy (Trinity College Dublin) Prof. Conor Buckley (Trinity College Dublin) Prof. Pieter Brama (University College Dublin) Dr. Garry Duffy (Royal College of Surgeons in Ireland) Prof. Kevin Mulhall, (Consultant Orthopaedic Surgeon, Mater University Hospital). Dr. Mary Murphy (NUI Galway) Dr. David Hoey (University of Limerick) Prof. Dennis McGonagle (University of Leeds) Prof. Chris Jacobs (Columbia University) Prof. Diane Wagner (University of Notre Dame) Prof. Kurt Hankenson (University of Pennsylvania School of Veterinary Medicine) Prof. Miguel Angel Martnez (University of Zaragoza) Prof. Tammy Donahue (Colorado State University) Dr. Nicholas Dunne (Queens University Belfast) Prof. Eben Alsberg (Case Western Reserve University) Prof Joel Boerckel (University of Notre Dame)
