Bio-IT Workshop: Positioning Your Firm. January 21, 2003

Understanding the Intersection Between Information Technology

and the Life Sciences

The Terrain

Bob RoyceVP Business Development

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

I want to conquer death!

I don’t want to be sick!

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

What is Bio-IT?

Information Technology

LifeSciences

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

“Biology is an information science”

Leroy Hood, Michigan Life Science Core Technology Alliance Inauguration

In vivoIn silico

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

“the language of biology

is sounding increasingly like the language of

systems engineering”

103 of 341 MIT engineering school faculty use the term “bio” to describe the nature of their research.  

Systems Biology at MIT: It’s All Over the Place By Adrienne Burke, Genome Technology editor-in-chief CAMBRIDGE, Mass., Jan. 9

MIT President Chuck Vest

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.Design Analysis

Optimization/Archive

Hypothesis -> ExperimentScientific Process Information

DNABiological Function

Genotype -> Phenotype

Biological Information

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

DNA: Where it all starts

Adenine Thymine

GuanineCytosine

The ultimate compression algorithm

A 4 letter code, 3 billion letters long…

… contains the recipe for building you and me

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

Genomics to Proteomics

Computational Chemistry and Protein Folding Homology Modeling

BioinformaticsSequenceAnalysis

Chemical DB’s,CombinatorialChemistry,Docking studies

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

From Genotype to Phenotype

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

Complex, Deeply Nested Layers of Data

QuickTime™ and aTIFF (Uncompressed) decompressorare needed to see this picture.

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

All this Produces an Information Explosion

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

Partnerships/Collaborations

Internal

Public

Data Domain

Data Type

PastPast

Static Dynamic

moderate controlof data format

high level of controlof data format

FuturePresent

no direct controlof data format

…That must be managed in a both a Public and Private Context

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

“There does seem to be a disconnect between the value proposition and what is offered,”

“In 50 percent of the interactions that I have with vendors, they say, ‘We have a great technology that can help you…. Now tell me about drug discovery ’ ” Rainer Fuchs, vice president of research informatics at Biogen

Shawn Ramer, vice president of R&D informatics at Bristol-Myers Squibb

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

Pharmaceutical R&D

$800 MFully CapitalizedCost to develop

$350 M SalesAvg. per year

Blockbusters (>$1B)Carry the rest...e.g. Lipitor

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

Pharmaceutical R&D

Bio-IT Workshop: Positioning Your Firm. January 21, 2003

Conclusion

•Current focus is on applied technology…– Must understand the drug discovery process.

•Complexity of industry should not be underestimated

– Pace of discovery and innovation is staggering– Partnerships and alliances are key

•Nobody has the “right” model….– Everybody knows they need new ways to solve the

problem– Fragmentation in solution space makes it difficult to get

economies of scale for technology development

• But the goal is noble and the prize is large!