Support Articles for “The Power of Ketone Supplementation

in Advancing the Quality of Your Life

Ketosis and General Nutrition 10 Significant Health Benefits of Low-Carb Ketogenic Diets:

http://authoritynutrition.com/10-benefits-of- low-carb-ketogenic-diets/

Ketogenic diet helps weight loss, alzheimer’s, MS and starves cancer say experts http://www.examiner.com/article/ketogenic-diet-aids-weight-loss-alzheimer-s-ms-and-starves-cancer-say-experts

Self Experiment in Nutritional Ketosis http://floriankugler.com/blog/2013/4/8/a-

self-experiment-with-nutritional-ketosis Ketones have therapeutic effects for diseases of substrate insufficiency or insulin

resistance: “The therapeutic implications of ketone bodies: the effects of ketone

bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism”

Great Overall Resource on Ketosis http://josepharcita.blogspot.com/2011/03/guide-to-ketosis.html

Effects of ketogenic Mediterranean Diet with phytoextracts and low

carbohydrates/high protein meals on weight, cardiovascular risk factors, body composition and diet compliance

http://www.ncbi.nlm.nih.gov/pubmed/21992535 Low carbohydrate nutrition and metabolism

http://ajcn.nutrition.org/content/86/2/276.long

Ketone Bodies: Potential Therapeutic Uses http://onlinelibrary.wiley.com/store/10.1080/152165401753311780/asset/713803

796_ftp.pdf?v=1&t=idt8myef&s=e986e82c336ecca887627591430579c86b0383ca

Improves Physical Performance – Ketones plus Glucose provide superior energy

o NFL Linemen turn to ketogenic diet http://www.wsj.com/articles/nfl- linemen-

turn-to-all- fat-no-carb-diet-but-science- is-unclear-1440117028

New ketone supplement all the rage in cycling

http://www.cyclingweekly.co.uk/news/latest-news/ketones-controversial-new-energy-drink-next-big-thing-cycling-151877

Enhanced Endurance in trained cyclists during moderate intensity exercise following 2 weeks adaptation to a high fat diet

http://link.springer.com/article/10.1007/BF00392032

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o Ketogenic Diet Decreased body fat without Negative effects on Strength Performance: “Ketogenic diet does not affect strength performance in elite artistic

gymnasts” o No impaired endurance performance when in ketosis:

http://www.nutritionandmetabolism.com/content/1/1/2 http://eatingacademy.com/how-a-low-carb-diet-affected-my-athletic-performance

Cognitive Improvement -

Fatty acids as well as ketone bodies can be metabolized by the brain: “A ketone ester diet increases brain malonyl-CoA and Uncoupling proteins 4 and 5 while decreasing food intake in the normal Wistar Rat”

The Effects of Beta-Hydroxybutyrate on Cognition http://www.ncbi.nlm.nih.gov/pubmed/15123336

Dietary ketosis enhances memory in mild cognitive impairment http://www.ncbi.nlm.nih.gov/pubmed/21130529/

Increased plasma ketone bodies resulted in a corresponding reduction in cerebral

metabolic rates of glucose: http://www.ncbi.nlm.nih.gov/pubmed/23736643 Under conditions of ketosis, glucose consumption is decreased in the cortex

and cerebellum: http://www.ncbi.nlm.nih.gov/pubmed/19227486 Gluten free ketogenic diet with MCTs reverses autism and eliminates

seizures http://healthimpactnews.com/2013/gluten-free-ketogenic-diet-with-mcts-

reverses-autism-and-eliminates-seizures/

Multiple Sclerosis

Doctor Reverses MS with Ketogenic Diet.

http://www.celebrityhealthfitness.com/29200/ketogenic-paleo-diet-

helps-physician-reverse-multiple-sclerosis-keto-also-fights-cancer/

Ketogenic Diet helps Alzheimer, MS, and Fights Cancer

http://www.examiner.com/article/ketogenic-diet-aids-weight-loss-

alzheimer-s-ms-and-starves-cancer-say-experts

Epilepsy

Epilepsy Foundation Web Site: Ketogenic Diet info: http://www.epilepsy.com/learn/treating-seizures-and-epilepsy/dietary-therapies/ketogenic-diet

Ketogenic Diet and other dietary treatments for Epilepsy

http://www.ncbi.nlm.nih.gov/pubmed/22419282 Marked Seizure Reduction after MCT Supplementation

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870649/

NY Times: Epilepsy’s Big Fat Miracle http://www.nytimes.com/2010/11/21/magazine/21Epilepsy-t.html?_r=0

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Alzheimers Disease A new way to produce hyperketonemia: use of a ketone ester in a case of

Alzheimer’s http://www.ncbi.nlm.nih.gov/pubmed/25301680 Ketosis Improves Cognitive Performance in Subjects with Alzheimer’s Disease:

“Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial”

Effects of beta-hydroxybutyrate on cognition in memory impaired adults

http://www.ncbi.nlm.nih.gov/pubmed/15123336

Neuroprotection for the Brain BRAIN, LIVIN’ ON KETONES – A MOLECULAR NEUROSCIENCE LOOK

AT THE KETOGENIC DIET “http://www.neurorexia.com/2013/03/24/brain-

livin-on-ketones-a-molecular-neuroscience-look-at-the-ketogenic-diet/ Ketogenic Diet in Neuromuscular and Neurodegenerative diseases

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101992/ Ketogenic Diet Provides Neuroprotective Effects Against Ischemic Stroke

Neuronal Damages http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312394/ The mitochondrial permeability transition pore provides a key to the diagnosis

and treatment of traumatic brain injury http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272646/

Ketone Bodies mediate antiseizure effects through mitochondrial permeability

transition http://onlinelibrary.wiley.com/doi/10.1002/ana.24424/abstract

Neuroprotective and disease-modifying effects of the ketogenic diet http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367001/

Nutrition and Traumatic Brain Injury: Improving Acute and Subacute Health

Outcomes in Military Personnel ( 2011 ) http://www.nap.edu/openbook.php?record_id=13121&page=140

Clinical review: Ketones and brain injury http://ccforum.com/content/15/2/219

Beneficial Effects of Ketosis on Neurological Disorders: “Therapeutic ketosis

with ketone ester delays central nervous system oxygen toxicity seizures in rats”

Great information on how Ketones help a number of diseases

http://www.holistichelp.net/blog/what-is-ketosis-and- is- it-dangerous/

Improving Insulin Insensitivity and Diabetes, Complications of Diabetes

Treatment of diabetes and diabetic complications with a ketogenic diet http://www.ncbi.nlm.nih.gov/pubmed/23680948

Insulin Sensitivity and Glucose Tolerance Are Altered by Maintenance on a Ketogenic Diet http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903931/

Reversal of Diabetic Nephropathy by a ketogenic diet

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080383/

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Ketogenic Diet Improves Insulin Sensitivity and Numerous Aging Markers http://articles.mercola.com/sites/articles/archive/2014/02/02/ketogenic-diet-

health-benefits.aspx?e_cid=20140202Z3_SNL_Art_1&utm_source=snl&utm_medium=

email&utm_content=art1&utm_campaign=20140202Z3&et_cid=DM39012&et_rid=414716167

Ketones have therapeutic effects for diseases of substrate insufficiency or insulin

resistance: “The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin

resistance, and mitochondrial metabolism” Long-term ketogenic diet reduces blood glucose:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/

Improving Cellular Health and Longevity, Anti-aging Ketogenic Diet Could Delay the Effects of Aging

http://www.medindia.net/news/ketogenic-diet-could-delay-the-effects-of-aging-

111146-1.htm Scientists see a Ketogenic Diet for Aging and Longevity

http://longevitycentresofamerica.wordpress.com/2012/12/09/scientists-see-potential- in-ketogenic-diet-for-aging-longevity/

Ketosis cleans our cells http://www.proteinpower.com/drmike/ketones-and-

ketosis/ketosis-cleans-our-cells/ Beta Hydroxybutyrate extends lifespan in C elegans.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169858/

Weight Loss - Fat loss without muscle loss

Mouse study identifies KE as a potential antiobesity supplement: “Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet KE as a potential antiobesity supplement”

Subjective Appetite Reduced on Ketogenic Diet: “Ketosis and appetite-mediating nutrients and hormones after weight loss”

Medium chain fatty acid acts in the liver to produce a signal that inhibits feeding in rats: “Caprylic acid infusion acts in the liver to decrease food intake in rats”

Ketogenic Diet Decreased body fat without Negative effects on Strength

Performance: “Ketogenic diet does not affect strength performance in elite artistic gymnasts”

Summary of the known central effects of BHBA: “Role of beta-hydroxybutyric acid in the central regulation of energy balance” Long-term ketogenic diet significantly reduced the body weight and body mass

index of the patients: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/

Cancer Inhibiting – Cancer cells can’t live using ketones as a fuel source

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http://www.naturalhealth365.com/stop_cancer/ketogenic_diet.html http://articles.mercola.com/sites/articles/archive/2013/03/10/ketogenic-diet.aspx

Open access to Dr. D’Agostino’s recent study on Cancer: “The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic

Metastatic Cancer” Ketogenic Diet and Cancer Benefits http://articles.mercola.com/sites/articles/archive/2013/06/16/ketogenic-diet-benefits.aspx

Ketones and cancer: “What is the Origin of Cancer?” Ketogenic Diet for Cancer - Clinical Trial http://coconutketones.blogspot.com/2013/01/ketogenic-diet-

for-cancer-clinical-trial.html Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric

oncology patients: two case reports.

http://www.ncbi.nlm.nih.gov/pubmed/7790697