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BARBITURICOS
OMAR EDUARDO PERDOMO CASTILLORI. ANESTESIOLOGIA Y REANIMACION
UNIVERSIDAD EL BOSQUE
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ASPECTOS HISTORICOS
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J. F. W. Adolph VonBa ! " #$%&'($)$*+
P" ,-o No l d Q/0,-1a$)2'.
S-n3 4-4 d l A1-doa" -3/"-1o $%56
Ronald. D. M-ll "7 M.D. El4 8- " 922'
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COMPOSICION ACIDOBARBITURICO
Urea mas Acido Malnico
Barbital: ( Acido dietil
barbiturico)Fisher y Von Mening 1.903
P"-, " 1o,p/ 43o 1onp"op- dad 4 4 dan3 4
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Somnifen.
Redonnet (1920)
M :1la d 4al 4a" -3/"-1a4.
E; 13o 4 dan3 d la"3"-1a4.
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Hexobarbital: ru!! y "aub ( 193#)
P"-, " a" -3/"-1o d a11-=n 1o"3a A,pl-a, n3 /4ado n E/"opa
Amobarbital ( 1929): U4ado n No"3 a, "-1a.
Barbituricos con azufre: # Ta , ! Val?-l "$.)&'+
Ronald. D. M-ll "7 M.D. El4 8- " 922'
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TIOPENTAL
Ral ! "aters # $o!n%und# (19&')
@ a 4/p "ado la p"/ a d l3- ,po
In-1-o d a11-=n " p-do7d/"a1-=n 1o"3a7 4-n lo4
; 13o4 1-3an3 4 d l
h o a" -3al.
E/3ana4-a n 1-"/
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PROPIEDADESFISICOQUIMICAS
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ACIDO BARBITURICO
#$%$& trio'ohe'ahidro!irimidina
A13-8-dad -pn=3-1a Rad-1al 4a"-lo( al /-lo n l 1a" ono '.
Con;-
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Rad-1al ; n-lo n la po4-1-=n 'p"op- dad an3-1on8/l4-8an3 .
No " 1on43-3/-" 1on La13a3o "-n< ".
E8-3a" la , :1la 1on o3"o4, d-1a, n3o47 / p/ d n -na13-8a" la,ol 1/la.
Ronald. D. M-ll "7 M.D. El4 8- " 922'
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ESTRUCTURA Y FUNCION
Ronald. D. M-ll "7 M.D. El4 8- " 922'
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METABOLISMO
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O IDACION
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D p nd- n3 d 4-43 ,a,-1"o4o,al.
Ind/11-=n n:-, 3-1a.S-n3 3a4a d 1-do
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FARMACOCINETICA DE
LOS BARBITURICOS
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odelo
ulticom artimental $. T ",-na1-=n d l
; 13o po43 "-o" aHn-1a do4-4.
( in tica de orden 1)9. R 3a"do d
" 1/p "a1-=npo43 "-o" a -n;/4-=n.
# 1-n>3-1a d o"d n 2 +
Ronald. D. M-ll "7 M.D. El4 8- " 922'
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VARIABLES MODIFICADORAS DEFARMACOCINETICA
Al3 "a1-on 4 h ,od-n ,-1a4.
Ma4a 1o"po"al ,a
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CONSIDERACIONES SEGUN EDAD
PEDIATRICOS GERIATRICOS
Ma!o" Vol/, n d d-43"- /1-=n.
Ma!o" a1la"a,- n3o.
M no" 1on1 n3"a1-=n l-p0d-1a nl SNC7 ,a!o" p"opo"1-=n d
a
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ELIMINACION
a43a /n &2 d lo4a" -3H"-1o4 4l-,-nan 4-n
,od-;-1a1-=n.
La l-,-na1-=n " nal4 a/, n3a 1on la
al1al-n-:a1-=n d lao"-na.
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FARMACODINAMIA
R 1 p3o" GABA
$. Po3 n1-a1-=n dn /"o3"an4,-4-=n
-nh- -3o"-a.Fa1-l-3a1-=n d la /n-=n GABA
9. M-, 3-4,o GABA
A/, n3o d l /, "al d1-3a -l-dad d la
, , "ana po4-n p3-1a.
Al "3o Van
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*lo+ueo deneurotransmisine'citatoria.
,ece!tores AM-A
E; 13o " 4/l3an3 A/, n3o d la4
1o""- n3 4 d 1lo"o.
Al "3o Van
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SITIOS DE ACCION
A13-8-dad d-; " n1-aln SNC.
E; 13op" do,-nan3 n l4-43 ,a " 3-1/la"a41 nd n3
a13-8ado".
Al "3o Van
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EFECTOS FISIOLOGICOS
D-4,-n/1-=n d l , 3a ol-4,o 1 " "al.
D-4,-n/1-=n d l BVO9 # 1on4/,o do 0< no 1 " "al+
D-4,-n/1-=n p"opo"1-onal d l ;l/ o
4an
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EFECTOS FISIOLOGICOS
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SISTEMA NERVIOSO PERIFERICO
E; 13o -nh- -3o"-o 4o " la 3"an4,-4-=nn "8-o4a n
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PASO AL SISTEMA NERVIOSOCENTRAL
p A
L-po;-l-1-dad
Un-=n a p"o3 0na4
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PASO AL SISTEMA NERVIOSOCENTRAL
p A T-op n3al *75 A p ;-4-ol=
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EFECTOS CARDIOVASCULARES
GC
PAM
RVS
Con3"a13-l-dad
FC #$2( &5 +
MVO9
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EFECTOS CARDIOVASCULARES
D p" 4-=n ,-o1 "d-1a A11-=n 4o " 1anal 4 d Na ! al
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EFECTOSRESPIRATORIOS
e!resin res!iratoria$dosis de!endiente.
Do4-4 &7' ,
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EFECTOS CLINICOS
IPNOSIS
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Do4-4 E; 13-8a '2
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BARBITURICOS
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DOSIS RECOMENDADAS PARAINDUCCION Y MANTENIMIENTO
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TIOPENTAL EN LAGESTACION
E /-l- "-o n3" la4 8 na4 ,a3 "na4 ! ; 3al n & ,-n/3o4.
El , a"a:o p"olon
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CONTRAINDICACIONES
-po8ol ,-a
Cho /
A4,a
-or/iria
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EFECTOS SECUNDARIOS
Sa o" a a o In1-d n1-a 62
E an3 ,a /"3-1a"-;o",
I""-3a1-=n lo1al. Dolo" n l 4-3-o d -n! 11-=n. )
Fl -3-4 $
E; 13o4 -3ado" 4 # , 3oh -3al+ To47 h-po73" ,o"7 4pa4,o4.
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GRACIAS