Autoimmune Disease Genetic Damage in Human Pathogenesis ... › sgw › documents › 1398471 ›...

Biomedicine springer.com/NEWSonline

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D. Adams, University of Otago, Dunedin, New Zealand

Autoimmune DiseasePathogenesis, Genetics, Immunotherapy, Prophylaxis and Principles for Organ Transplantation

This book describes how the Jerne-Burnet Forbid-den Clone Theory and the Adams-Knight H Gene Theory, solved the pathogenesis and genetics of the autoimmune diseases showing how specific immunotherapy and prophylaxis can be devel-oped. Furthermore, Ebringer’s discovery of two microbial triggers of autoimmune diseases is described and the conclusion drawn that all auto-immune diseases have microbial triggers, so will be preventable by the finding of the triggers and vaccination against them.

Features 7 Explains that all autoimmune diseases have mi-crobial triggers 7 Provides strong evidence that schizophrenia is an autoimmune disease 7 Dem-onstrates that prophylaxis of the autoimmune diseases will be possible by finding and vaccinat-ing against their microbial triggers

Contents Discovery.- Pathogenesis.- Genetics.- Microbial Triggers.- Immunotherapy.- Prophylaxis.- Trans-plantation.

Fields of interestBiomedicine general; Medicine/Public Health, general

Target groupsResearch

Discount groupMedical Professional

Due August 2013

2013. X, 55 p. 21 illus., 10 in color. (SpringerBriefs in Public Health) Softcover7 $49.99ISBN 978-94-007-6936-6

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Y. H. Bae, University of Utah, Salt Lake City, UT, USA; R. Mrsny, University of Bath, Claverton Down, UK; K. Park, Purdue University, West Lafayette, IN, USA (Eds)

Cancer Targeted Drug DeliveryAn Elusive Dream

Contents A Time Travel Journey Through Cancer Thera-pies.- Nanotechnology for Cancer Treatment: Possibilities & Limitations.- Vascular Targeting Approaches to Treat Cancer.- Tumor Immu-notherapy by Utilizing a Double-Edged Sword Chemokines.- Cancer Biology: Some Causes for a Variety of Different Diseases.- Cancer Stromal Targeting (CAST) Therapy and Tailored Antibody Drug Conjugate Therapy Depending on Nature of Tumor Stroma.- Cancer Cell Respiration: Hypoxia and pH in Solid Tumors.- Tumor Vasculature, EPR Effect, and Anticancer Nanomedicine: Con-necting the Dots.- Pressure Gradients in Solid Tumors.- The ADAMs: New Therapeutic Targets for Cancer?.- Role of the Extracellular Matrix – Enzyme Activities and Metastasis.- The Role of Non-Cancerous Cells in Cancer: Pancreatic Ductal Adenocarcinoma as Model to Understand the Impact of Tumor Microenvironment on Epi-thelial Carcinogenesis.- Heterogeneity of Cancers and its Implication for Targeted Drug Delivery.- A Study of Cancer Heterogeneity: From Genetic Instability to Epigenetic Diversity in Colorectal Cancer.- Nanotherapeutics in Multidrug Resis-tance.- Stem Cells and Cancer.- Mechanisms of Metastasis.- Cancer-Specific Ligand/Receptor Interactions.- Targeting Drugs to Cancer: A Tough Journey to the Tumor Cell.- Long Circulation and Tumor Accumulation.- Convective and Diffusive Transport in Drug Delivery.- Intravital Real-Time Confocal Laser Scanning Microscopy for the in Situ Evaluation of Nanocarriers. [...]

Fields of interestPharmaceutical Sciences/Technology; Pharmacol-ogy/Toxicology


Discount groupProfessional Non-Medical

Due July 2013

2013. X, 823 p. 117 illus., 86 in color. Hardcover7 $239.00ISBN 978-1-4614-7875-1

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E. Baldi, Ph.D., M. Muratori, Ph.D., University of Florence, Italy (Eds)

Genetic Damage in Human SpermatozoaThere are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogen-esis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

Features 7 This book will cover all possible DNA damage in sperm 7 The book will also discuss its relation to fertility and transgenerational heritable ef-fects 7 Chapter structure will include mecha-nisms of damage, consequences in reproduction, possibility to eliminate damage, and possible transgenerational heritable effects

Contents Structure of chromatin in spermatozoa.- Genomic changes in spermatozoa of aging male.- Chromo-somal aberrations and aneuploidies.- The sperm epigenome: implications for the embryo.- Paternal reprogramming of genome: transgenerational ef-fects.- Alterations in protamination.- Sperm DNA fragmentation and base oxidation.- Iatrogenic Genetic damage.- Sperm selection: effect on sperm DNA quality.- Effect of antioxidant treatments on sperm genetic damage.- Index.

Fields of interestHuman Genetics; Endocrinology; Reproductive Medicine



Due August 2013

2014. X, 261 p. 22 illus., 17 in color. (Advances in Experimental Medicine and Biology, Volume 791) Hardcover7 $189.00ISBN 978-1-4614-7782-2

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www.springer.com/978-94-007-6936-6



News 6/2013 Biomedicine

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D. Barh, The Institute of Integrative Omics and Applied Biotechnology, West Bengal, India; D. Dhawan, B.V.Patel Pharmaceutical Education and Research Development Centre, Gujarat, India; N. K. Ganguly, National Institute of Immunology, Delhi, India (Eds)

Omics for Personalized MedicineContents Pharmaco-Geno-Proteo-Metabolomics and Per-sonalized Medicine-An overview.- Personalized genome, current status and the future of harma-cogenomic.- Next generation sequencing (NGS): a revolutionary technology in pharmacogenomics and personalized medicine.- Pharmaco-epig-enomics.- Personalized nutrition and drug-nutri-ent interactions.- Designing and Implementing Pharmacogenomics Study.- Omics approaches and applications in Clinical Trials.- Ethical Consid-erations in Pharmacogenomics.- Computational Pharmacogenomics.- Pharmacogenomics in the era of personal genomics: a quick guide to online resources and tools.- Pharmacogenomics and Per-sonalized Medicine for Cancer.- Pharmacogenom-ics in acute myeloid leukemia.- Pharmacogenom-ics of autoimmune diseases.- Pharmacogenomics and personalized medicine in Parkinsonism.- Pharmacogenomics and personalized medicine in Alzheimer’s disease.- Pharmacogenomics and Personalized Medicine in Mood Disorders.- Phar-macogenetics of opioid and alcohol addiction.- Neurogenetics and Nutrigenomics of Reward Deficiency Syndrome (RDS): Stratification of Addiction Risk and Mesolimbic Nutrigenomic Manipulation of Hypodopaminergic Function.- Pharmacogenomics of analgesics.- Cardiovascular Disease Pharmacogenomics.- Pharmacogenetics of Oral Anticoagulants. [...]

Fields of interestBiomedicine general; Human Genetics; Metabo-lomics



Due August 2013

2014. Approx. 820 p. 73 illus., 58 in color. Hardcover7 $279.00ISBN 978-81-322-1183-9

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New SeriesResistance to Targeted Anti-Cancer TherapeuticsSeries editor: B. Bonavida

For several decades, treatment of cancer consisted of chemotherapeutic drugs, radiation, and hor-monal therapies. Those were not tumor specific and exhibited severe toxicities in many cases. But during the last several years, targeted cancer thera-pies have been developed. Targeted cancer thera-pies are drugs or other agents (e.g. antibodies) that block the growth and spread of cancer by interfer-ing with specific gene products that regulate tu-mor cell growth and progression. Targeted cancer therapies are also sometimes called “molecularly targeted drugs.” We have witnessed in the last decade a significant explosion in the development of targeted cancer therapies developed against various specific cancers. These include drugs/anti-bodies that interfere with cell growth signaling or tumor blood vessel development, promote the cell death of cancer cells, stimulate the immune system to destroy specific cancer cells and to deliver toxic drugs to cancer cells. One of the major problems that arise following treatment with both conven-tional therapies and targeted cancer therapies is the development of resistance, preexisting in a subset of cancer cells or cancer stem cells and/or induced by the treatments. Tumor cell resistance to therapies remains a major problem and several strategies are being considered to reverse the resistance to various manipulations. Resistance to Targeted Anti-Cancer Therapeutics will focus on the basic and translational research behind the molecular mechanisms of resistance found in many kinds anti-cancer therapeutics.

B. Bonavida, University of California, Los Angeles, CA, USA (Ed)

Resistance to Immunotherapeutic Antibodies in CancerStrategies to Overcome Resistance

The traditional approaches to treat various cancers include chemotherapy, radiation and/or hormonal therapy. While these therapies continue to be effective in large part, they are not selective and highly toxic.

Features 7 Summarizes common and unique features of mAbs against various cancers 7 Explores the latest developments on the molecular, biochemical and genetic mechanisms of resistance by various mAbs 7 Covers the potential use of the combi-nation treatment of mAbs with other drugs/mAbs to reverse resistance

Contents Preface.- Introduction and generation of chimeric and humanized mAbs.- mAbs targeted against cancer cells and antibodies targeted against the tumor microenvironment.- Antibodies directed against different major cancers: Effects when used alone or in combination with drugs.- Mech-anisms of antibodies-mediated responses, in vitro and in vivo.- Molecular Pathways.- Molecular Signatures.- Identification of resistance targets for intervention.- Various chemicals that can sensitize resistant tumor cells.- Other mAbs.- Proteasome inhibitors.- Divalent mAbs.- Antibodies coupled to chemical inhibitors.- Antibodies coupled to cytokines.- Nanoparticles with mAbs.- Index.

Fields of interestCancer Research; Molecular Medicine; Immunol-ogy



Due June 2013

2013. XI, 342 p. 29 illus., 15 in color. (Resistance to Targeted Anti-Cancer Therapeutics, Volume 2) Hardcover7 $189.00ISBN 978-1-4614-7653-5

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T. Borisova, National Academy of Sciences of Ukraine, Kiev, Ukraine

Cholesterol and Presynaptic Glutamate Transport in the BrainGlutamate is the primary excitatory neurotrans-mitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders. Appropri-ate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced levels of cholesterol have been implicated in the pathogenesis of disorders such as stroke, ischemia, traumatic brain injury, and neurotoxicity. In the proposed book, the author presents data from the literature and from her own lab to address the extent to and way in which membrane cholesterol modulates presynaptic glu-tamate transport and whether lowering the level of cholesterol available can offer some neuroprotec-tive benefits.

Features 7 Reviews the literature on the role of cholesterol in brain function 7 Examines the neuropro-tective aspects of lower cholesterol 7 Medical doctors will be especially interested in the data on statins

Contents Presynaptic glutamate transport in the brain.- Cholesterol and its role in synaptic transmission.- Effects of cholesterol-depleting agent methyl-b-cyclodextrin (MbCD) on the functional state of brain nerve terminals.- The extracellular level and uptake of glutamate in cholesterol-deficient nerve terminals.- Unstimulated and exocytotic glutamate release from cholesterol-deficient nerve termi-nals.- Neuroprotection by lowering cholesterol.

Fields of interestNeurosciences; Neurochemistry



Due July 2013

2013. VIII, 92 p. 50 illus., 15 in color. (SpringerBriefs in Neuroscience, Volume 12) Softcover7 $49.99ISBN 978-1-4614-7758-7

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R. J. Carbajo, Centro de Investigación Príncipe Felipe, Valencia, Spain; J. L. Neira, Universidad Miguel Hernández, Elche, Spain

NMR for Chemists and BiologistsThis book intends to be an easy and concise introduction to the field of nuclear magnetic resonance or NMR, which has revolutionized life sciences in the last twenty years. A significant part of the progress observed in scientific areas like Chemistry, Biology or Medicine can be ascribed to the development experienced by NMR in recent times. Many of the books currently available on NMR deal with the theoretical basis and some of its main applications, but they generally demand a strong background in Physics and Mathemat-ics for a full understanding. This book is aimed to a wide scientific audience, trying to introduce NMR by making all possible effort to remove, without losing any formality and rigor, most of the theoretical jargon that is present in other NMR books. Furthermore, illustrations are provided that show all the basic concepts using a naive vector formalism, or using a simplified approach to the particular NMR-technique described.

Features 7 Introduces NMR in a friendly way for the non specialist 7 Provides the basic foundations of NMR in a non-mathematical form 7 Provides a succinct view of the most recent and important biological applications of NMR 7 Explains in a clear way the n-dimensional NMR techniques

Contents The basis of Nuclear Magnetic Resonance Spec-troscopy.- Spectroscopic parameters in Nuclear Magnetic Resonance.- Basic NMR experiments.- Biomolecular NMR.

Fields of interestBiomedicine general; Spectroscopy/Spectrometry; Biotechnology



Due June 2013

2013. VIII, 118 p. 36 illus. (SpringerBriefs in Biochemistry and Molecular Biology) Softcover7 $49.99ISBN 978-94-007-6975-5

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T. Catalano, PharmChem Analytical Consultants LLC, Buffalo Grove, IL, USA

Essential Elements for a GMP Analytical Chemistry DepartmentEssential Elements for a GMP Analytical Chem-istry Department is a systematic approach to understanding the essential elements required for a successful GMP Analytical Department to function as an efficient and effective organization. It describes in detail a department structure which allows for the necessary processes to become avail-able to all its personnel in a way where there is a free flow of information and interaction.

Features 7 Describes a systematic approach to establishing an effective GMP analytical department 7 Dis-cusses the development and management of proj-ect teams 7 Describes an outsourcing process to ensure all activities are properly addressed and none are overlooked

Contents Introduction.- Organization.- Department Struc-ture.- Project Teams.- Responsibilities.- Interac-tions.- Operating Guidance’s.- Processes.- Safety.- Technology.- Department.- Statistical Concepts for the Analytical Chemist.- Data distribution.- Significance Testing.- Confidence Intervals.- Out-liers in analytical data.- Regression.- Experimental design.- Required sample replicates.- Method performance.- Uncertainty measurement.- Sam-pling strategies.- Outsourcing.- Process.- Audit Check List.- Documentation.- Sample Submis-sion.- Technical Report.- Reports of analysis.- Re-cords (Training etc.).- Job Descriptions.- Career Tracks.- Motivating Personnel.- Career Path.- Hir-ing the Best.

Field of interestPharmaceutical Sciences/Technology



Due June 2013


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43

D. J. Crommelin, Utrecht University, The Netherlands; R. D. Sindelar, University of British Columbia, Vancouver, BC, Canada; B. Meibohm, University of Tennessee, Memphis, TN, USA (Eds)

Pharmaceutical BiotechnologyFundamentals and Applications

Contents Molecular Biotechnology: From DNA sequence to therapeutic protein.- Biophysical and Biochemical Analysis of Recombinant Proteins.- Production and purification of Recombinant Proteins.- For-mulation of Biotech Products, including Biophar-maceutical Considerations.- Pharmacokinetics and Pharmacodynamics of Peptide and Protein Therapeutics.- Immunogenicity of Therapeutic Proteins.- Monoclonal Antibodies: From Structure to Therapeutic Application.- Genomics, Other “Omics” Technologies, Personalized Medicine and Additional Biotechnology-Related Techniques.- Dispensing Biotechnology Products: Handling, Professional Education and Product Information.- Economic Considerations in Medical Biotechnol-ogy.- Regulatory Framework for Biosimilars.- In-sulin.- Follicle-Stimulating Hormone.- Human Growth Hormone.- Recombinant Coagulation Factors And Thrombolytic Agents.- Monoclonal Antibodies in Cancer.- Hematopoietic Growth Factors: Focus on Erythropoiesis-Stimulating Agents.- Monoclonal Antibodies in Solid Organ Transplantation.- Interferons and Interleukins.- Vaccines.- Oligonucleotides.- Gene Therapy.- Stem Cell Technology.

Fields of interestPharmaceutical Sciences/Technology; Biomedi-cine general

Target groupsProfessional/practitioner


Due August 2013

4th ed. 2014. XXIV, 492 p. 215 illus., 168 in color. Hardcover7 $209.00ISBN 978-1-4614-6485-3

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C. De Nardo, E. Latz, University of Bonn, Germany (Eds)

The InflammasomeMethods and Protocols

Inflammasomes have a seemingly simple archi-tecture.

Features 7 Presents current up-to-date methodolo-gies 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Contents Assessing b-amyloid-induced NLRP3 Inflamma-some Activation in Primary Microglia.- Activating the NLRP3 Inflammasome using the Amyloido-genic Peptide IAPP.- Assessment and Quantifica-tion of Crystal-induced Lysosomal Damage.- As-sessment of Inflammasome Activation in Primary Human Immune Cells.- NLRP3 Inflammasome Activation and Cytotoxicity Induced by particulate Adjuvants.- Measuring Inflammasome Activa-tion in Response to Bacterial Infection.- Detec-tion of Pyroptosis by Measuring Released Lactate Dehydrogenase Activity.- ASC Speck Formation as a Read-out for Inflammasome Activation.- Im-munoblotting for Active Caspase-1.- Inflam-masome Activation and Inhibition in Primary Murine Bone Marrow-Derived Cells, and Assays for IL-1α, IL-1β and Caspase-1.- Reconstituting the NLRP1 Inflammasome in vitro.- Assessing ATP Binding and Hydrolysis by NLR Proteins.- Blue Native Polyacrylamide Gel Electrophoresis to Monitor Inflammasome Assembly and Com-position.- Analysis of Microbiota Alterations in Inflammasome-deficient Mice.- Quantification of Adipose Tissue Leukocytosis in Obesity.- In vivo Evaluation of Neutrophil Recruitment in Response to Sterile Particulates.

Fields of interestImmunology; Cytokines and Growth Factors



Due July 2013

2013. XIV, 232 p. 44 illus., 21 in color. (Methods in Molecular Biology, Volume 1040) Hardcover7 $119.00ISBN 978-1-62703-522-4

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L. A. del Río, Estación Experimental del Zaidín, Granada, Spain (Ed)

Peroxisomes and their Key Role in Cellular Signaling and Metabolism Contents Peroxisome interactions and cross-talk with other subcellular compartments in animal cells.- Per-oxisomes in human health and disease: metabolic pathways, metabolite transport, interplay with other organelles and signal transduction.- Aging, age-related diseases and peroxisomes.- Peroxi-somes and the antiviral responses of mammalian cells.- Peroxisome proliferator-activated receptor-α signaling in hepatocarcinogenesis.- Involvement of human peroxisomes in biosynthesis and signal-ing of steroid and peptide hormones.- Peroxisome Ca2+ homeostasis in animal and plant cells.- The versatility of peroxisome function in filamentous fungi.- Essential roles of peroxisomally produced and metabolized biomolecules in regulating yeast longevity.- Metabolite transporters of the plant peroxisomal membrane - known and unknown.- Peroxisomes and photomorphogenesis.- Biosyn-thesis of vitamin K1 (phylloquinone) by plant peroxisomes and its integration into signaling molecule synthesis pathways.- Role of peroxi-somes as a source of reactive oxygen species (ROS) signaling molecules.- Peroxisomes as a source of auxin signaling molecules.- Peroxisomes as cell generators of reactive nitrogen species (RNS) signal molecules.- Role of plant peroxisomes in the production of jasmonic acid-based signals.- Role of plant peroxisomes in protection against herbivores.- Function of Peroxisomes in Plant-Pathogen Interactions.

Fields of interestBiomedicine general; Cell Biology; Cell Physiology



Due July 2013

2013. XIV, 353 p. 59 illus., 45 in color. (Subcellular Biochemistry, Volume 69) Hardcover7 $199.00ISBN 978-94-007-6888-8

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A. Dhawan, M. Bajpayee, Ahmedabad University, Gujarat, India (Eds)

Genotoxicity AssessmentMethods and Protocols

Contents Bacterial Mutation Assays.- In Vitro Mouse Lymphoma (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay.- Erythrocyte--Based Pig--a Gene Mutation Assay.- Detection of in vivo Mutation in the Hprt and Pig--a Genes of Rat Lympho-cytes.- In vivo cII, gpt, and Spi- gene Mutation Assays in Transgenic Mice and Rats.- In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests.- Analysis of Chromo-some Aberrations in Somatic and Germ Cells of the Mouse.- Chromosomal Aberration Test in Human Lymphocytes.- In vivo Micronucleus Assay in Mouse Bone Marrow and Peripheral Blood.- Micronucleus Assay in Human Cells: Lymphocytes and Buccal Cells.- Flow Cytometric Determination of Micronucleus Frequency.- Fluo-rescent in situ Hybridization (FISH) Technique for the Micronucleus Test.- Comparative Genomic Hybridization (CGH) in Genotoxicology.- The in vitro Micronucleus Assay and Kinetochore Stain-ing: Methodology and Criteria for the Accurate Assessment of Genotoxicity and Cytotoxicity.- g--H2AX Detection in Somatic and Germ Cells of Mice.- Multicolour Laser Scanning Confocal Immunofluorescence Microscopy of DNA Dam-age Response Biomarkers.- The Comet Assay: Assessment of in vitro and in vivo DNA Damage.- The Comet Assay in Human Biomonitoring.- The Comet assay in Marine Animals.- Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo.- 32P--Postlabeling Analysis of DNA Adducts.- Micronucleus Assay with Tetrad Cells of Tradescantia.- The Wing--Spot and the Comet Tests as useful Assays Detecting Genotoxicity in Drosophila. [...]

Fields of interestPharmacology/Toxicology; Human Genetics



Due July 2013

2013. XII, 472 p. 106 illus., 62 in color. (Methods in Molecular Biology, Volume 1044) Hardcover7 $139.00ISBN 978-1-62703-528-6

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L. Ducry, Lonza AG, Visp, Switzerland (Ed)

Antibody-Drug Conjugates Contents Antibody-Drug Conjugate (ADC) Clinical Pipe-line: A Review.- Antibody-Drug Conjugate Target Selection: Critical Factors.- Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy: Internalization and Intracellular Localization.- Antibody-Drug Conjugate Payloads.- Linker Technologies for Antibody-Drug Conjugates.- In Vivo Testing of Drug-Linker Stability.- Phar-macokinetics and ADME Characterizations of Antibody-Drug Conjugates.- Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment.- Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Target-ing.- Protocols for Lysine Conjugation.- Engineer-ing THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers.- Enzymatic Antibody Modification by Bacterial Transglutaminase.- For-mulation Development of Antibody-Drug Con-jugates.- Conjugation Process Development and Scale-Up.- Methods for Conjugating Antibodies to Nanocarriers.- Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy.- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydro-phobic Interaction Chromatography and Reversed Phase High Performance Liquid Chromatogra-phy.- Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS.- Determination of Charge Heterogeneity and Level of Unconjugat-ed Antibody by Imaged cIEF.- Risk-Based Scien-tific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody-Drug Conjugates (ADCs).

Fields of interestPharmacology/Toxicology; Oncology



Due July 2013

2013. XV, 255 p. 95 illus., 41 in color. (Methods in Molecular Biology, Volume 1045) Hardcover7 $139.00ISBN 978-1-62703-540-8

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A. Emili, J. Greenblatt, University of Toronto, ON, Canada; S. Wodak, The Hospital for Sick Children, Toronto, ON, Canada (Eds)

Systems Analysis of Chromatin-Related Protein Complexes in Cancer Contents Preface.- Systematic proteomic analysis of histone demethylating enzymes linked to cancer.- His-tone methylating protein complexes in cancer.- Chromatin protein-protein interaction networks linked to cancer.- Structural genomics and drug discovery for chromatin-related protein complexes involved in histone tail recognition.- Transcription factories and global chromatin (enhancer) interac-tions in cancer.- Long ncRNAs associated with chromatin complexes and their role in cancer.- Fa-milial and somatic mutations of histone modifying enzymes in cancer.- Chromatin regulators arising from RNAi screens of transformed cancer cell lines.- Chromatin complexes in cancer.- Exploring dynamics of chromatin complexes in cancer based on quantitative proteomics.- Regulatory ncRNAs and their targets.- ncRNA regulatory networks in cancer.- Decoding BAF remodelling complexes in cancer.- Mediator/cohesin complex in cancer.- miRNAs targeting chromatin-related protein complexes regulate epigenetic states in cancer.- Polycomb group protein complexes in cancer stem cells.- Genetic interactions between chromatin factors in cancer cell lines.- Chromatin complexes in DNA repair.- Chromatin complexes in chromo-some segregation.- Evolution, co-expression and domain architecture of CM complexes linked to cancer .- Index.

Fields of interestCancer Research; Systems Biology; Human Genet-ics



Due August 2013


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E. O. Freed, National Cancer Institute, Frederick, MD, USA (Ed)

Advances in HIV-1 Assembly and Release Over the past decade, enormous progress has been made in understanding the late events in the HIV replication cycle. This has been made possible by major advances in cell biology, virology, and structural biology. The field continues to move forward rapidly, with important new discoveries being reported on a regular basis. The impact of this progress across a broad spectrum of biomedi-cal research has been substantial. The increase in basic knowledge in the areas of HIV assembly, release, and maturation has been accompanied by new possibilities for therapeutic intervention.The work includes topics relating to basic molecular biology, cell biology, and structural biology of HIV assembly, coupled with more applied ideas of how this basic information can inform the field of antiretroviral research.

Features 7 Contains full-color illustrations 7 Incorpo-rates tremendous advances in understanding of HIV-1 replication at the molecular level 7 Show-cases a number of central topics related to HIV-1 assembly

Contents Structural Biology of HIV Assembly.- Cellular Trafficking Mechanisms in the Assembly and Release of HIV.- Packaging of the HIV-1 RNA Genome.- Synthesis of Functional and Variable HIV-1 Envelope Glycoproteins.- HIV-1 Budding.- HIV-1 Maturation.- Cell-to-Cell Transmission of HIV.- Virus Assembly as a Target for Antiretrovi-ral Therapy.

Fields of interestVirology; Immunology; Medical Microbiology



Due July 2013

2013. VIII, 163 p. 36 illus., 31 in color. Hardcover7 $209.00ISBN 978-1-4614-7728-0

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U. Gophna, Tel Aviv University, Israel (Ed)

Lateral Gene Transfer in EvolutionFeatures 7 Focuses on the spectrum of adaptive inno-vations generated by Lateral Gene Transfer in evolution 7 Looks at the genomic, metabolic and ecological levels 7 Examines the integration of new genes into existing networks

Contents Part I: LGT-Driven Metabolic Innovations and Adaptations.- Lateral Gene Transfer and the Synthesis of Thymidine.- Lateral Gene Transfer and the Evolution of Photosynthesis in Eukary-otes.- On the Eco-evolutionary Relationships of Fresh and Salt Water Bacteria and the Role of Gene Transfer in their Adaptation.- Mobilized In-tegrons: Team Players In The Spread of Antibiotic Resistance Genes.- Plasmids of the bovine Ru-men.- Part II: The Integration of New Genes into Existing Networks.- Lateral Gene Transfer and Cellular Networks.- The Complexity Hypothesis and Other Connectivity Barriers to Lateral Gene Transfer.- How Codon Usage Shapes Gene Trans-fer and Vice Versa.- Part III: Inter-domain Gender Transfer.- Lateral Gene Transfer in Animals.- Gene Transfer and the Chimeric Nature of Eu-karyotic Genomes.- Gene transfer from Eukary-otes to Legionella.- Application of a new Mapping Algorithm to Reevaluate Evidence of Interdomain Horizontal Gene Transfer in the Genome of Thermotoga Maritime.- Part IV: LGT, Speciation and the Tree/Web of Life.- Gradual Speciation and its Implications for the Tree of Life.- Biased Gene Transfer Contributes to Maintaining the Tree of Life.- Speciation in the Shadow of Recombination and Lateral Gene Transfer.- Index.

Fields of interestHuman Genetics; Microbial Genetics and Genom-ics; Evolutionary Biology



Due July 2013

2013. I, 443 p. 48 illus., 27 in color. Hardcover7 $189.00ISBN 978-1-4614-7779-2

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M. Humbert, Hôpital Antoine Béclère, Paris, France; O. V. Evgenov, Harvard Medical School, Boston MA, USA; J.‑P. Stasch, Bayer HealthCare, Wuppertal, Germany (Eds)

Pharmacotherapy of Pulmonary Hypertension Contents Preface.- Part I. Pulmonary hypertension: con-ceptual bases of the disease. Pulmonary hyperten-sion: definition, classification, and epidemiology. Pulmonary hypertension: pathophysiology and signalling pathways. Pulmonary hypertension: pathology. Pulmonary hypertension: biomarkers. Pulmonary hypertension: animal models.- Part II. Pulmonary hypertension: established thera-pies. General supportive care. Calcium channel blockers. Prostacyclins. Endothelin receptor antagonists. Phosphodiesterase 5 inhibitors.- Part III. Pulmonary hypertension: novel pathways and emerging therapies Soluble guanylate cyclase stimulators. Therapeutics targeting dysregulated redox equilibrium and endothelial dysfunction (NOXs, sGC activators, GSNOR). Rho-kinase in-hibitors. Serotonin transporters and serotonin re-ceptors. PDGF inhibitors. Novel anti-proliferative strategies beyond imatinib. Immunosuppressive agents. Vasoactive peptides. Inhibitors of cGMP/cAMP metabolism (MRP4, MRP5, PDE1). Old targets re-visited. Stem cells and cell based thera-py.- Part IV. Conclusions and Outlook. Pulmonary hypertension: evidence-based management in the modern era and future directions.

Fields of interestPharmacology/Toxicology; Pharmaceutical Sci-ences/Technology; Internal Medicine



Due October 2013

2014. Approx. 450 p. (Handbook of Experimental Pharmacology, Volume 218) Hardcover7 approx. $419.00ISBN 978-3-642-38663-3

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D. M. Hunt, M. W. Hankins, S. P. Collin, N. J. Marshall (Eds)

Evolution of Visual and Non-visual PigmentsResearch on the evolution of visual and non-visual pigments is both exciting and timely. There is an explosion of interest in visual pigments across both invertebrates and vertebrates and the discov-ery of non-visual pigments involved in irradiance detection and photoentrainment as opposed to image formation is undergoing a revolution. How do these two pigments systems operate to provide both vision and circadian regulation in animals from different light environments? Non-visual pigments have now been discovered in non-pho-toreceptor cells in the retina, the pineal/parapineal complex, deep-brain receptors, the skin, the iris and even the liver.

Contents 1. The evolution of pineal and parapineal phot-opigments (Matsumasa Koyanagi) 2. The evolu-tion and function of melanopsin (Wayne Davies) 3. The evolution of non-visual photopigments in the CNS of vertebrates (Mark Hankins) 4. The evolution of invertebrate photoreceptors and phot-opigments (Tom Cronin) 5. Visual adaptations in insect photopigments (Amanda Briscoe) 6. The evolution of photoreceptors and visual photopig-ments in vertebrates (David Hunt) 7. Diversity and functional properties of bistable photopigments (Akihisa Terakita) 8. Adaptations to dim light (Ju-lian Partridge) 9. The role of visual photopigment evolution in speciation (Karen Carleton) Authors have not been confirmed.

Fields of interestNeurosciences; Ophthalmology; Cell Biology



Due September 2013

2014. Approx. 350 p. (Springer Series in Vision Research) Hardcover7 approx. $189.00ISBN 978-1-4614-4354-4

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B. Joseph, Karolinska Institutet, Stockholm, Sweden; J. L. Venero, University of Seville, Spain (Eds)

MicrogliaMethods and Protocols

Contents A Brief Overview of Multi-Talented Microglia.- Cell Culturing of Human and Murine Microglia Cell Lines.- Microglia Isolation from Adult Mouse Brain.- Preparation of Primary Microglia Cultures from Postnatal Mouse and Rat Brains.- Isolation of Murine Postnatal Brain Microglia for Phenotypic Characterization Using Magnetic Cell Separa-tion Technology.- Isolation and Culture of Adult Human Microglia within Mixed Glial Cultures for Functional Experimentation and High Content Analysis.- Depletion of Microglia from Primary Cellular Cultures.- Lentiviral Transduction of Cultured Microglia.- Microglial Activation: Measurement of Cytokines by Flow Cytometry.- In situ Hybridization of Cytokine mRNA using Alkaline Phosphatase Labelled Oligodeoxynucleo-tide Probes.- Use of Meso-scale DiscoveryTM to Examine Cytokinecontentin Microglia Cell Supernatant.- Analysis of Microglial Production of Reactive Oxygen and Nitrogen Species.- Quanti-fication of Active Caspase-3 and Active Caspase-8 in Microglia Cells.- Quantification of Microglial Phagocytosis by a Flow Cytometer-based Assay.- Quantification of Microglial Proliferation and Apoptosis by Flow Cytometry.- Fluorescence Im-aging of Intracellular Ca2+, Na+ and H+ in Cul-tured Microglia.- Patch Clamp Protocols to Study Ion Channel Activity in Microglia.- Studying M1 and M2 States in Adult Microglia.- Isolating, Cul-turing, and Polarizing Primary Human Adult and Fetal Microglia.- Understanding Microglia-neuron Cross-talk: Relevance of the Microglia-neuron Co-cultures.- Preparation of Rodent Primary Cultures for Neuron-Glia, Mixed Glia, Enriched Microglia, and Reconstituted Cultures with Microglia. [...]

Fields of interestNeurosciences; Neurobiology



Due July 2013


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P. Kolhe, Pharmaceutical R&D-BioTx Pharmaceutical Sciences, Chesterfield, MO, USA; M. Shah, InnoPharma Inc., Piscataway Township, NJ, USA; N. Rathore, Amgen, Thousand Oaks, CA, USA (Eds)

Sterile Product DevelopmentFormulation, Process, Quality and Regulatory Considerations

Contents Basic Principles of Sterile Product Formulation Development.- Molecule and Manufacturabil-ity Assessment Leading to Robust Commercial Formulation for Therapeutic Proteins.- Polymer and Lipid Based Systems for Parenteral Drug Delivery.- Formulation Approaches and Strategies for PEGylated Biotherapeutics.- Nasal Delivery.- Formulation Approaches and Strategies for Vac-cines and Adjuvants.- Challenges in Freeze-Thaw Processing of Bulk Protein Solutions.- Best Prac-tices for Technology Transfer of Sterile Products: Case Studies.- Transfer Across Barrier Systems: A New Source of Simplification in Aseptic Fill and Finish Operations.- Challenges and Innovation in Aseptic Filling: Case Study with the Closed Vial Technology.- Contemporary Approaches to Development and Manufacturing of Lyophilized Parenterals.- Polymer based prefilled syringe systems.- Advances in Container Closure Integrity Testing.- Pen and Autoinjector Drug Delivery Devices.- Particulate Matter in Sterile Parenteral Products.- Appearance Evaluation of Parenteral Pharmaceutical Products.- Sterile Filtration Principles, Best Practices and New Develop-ments.- Intravenous Admixture Compatibility for Sterile Products: Challenges and Regulatory Guid-ance.- Basics of Sterilization Methods.- Avoiding Common Errors during Viable Microbial Con-tamination Investigations.- Validation of Rapid Microbiology Methods (RMMs). [...]

Fields of interestPharmaceutical Sciences/Technology; Biomedi-cine general



Due October 2013

2014. IX, 471 p. 99 illus., 69 in color. (AAPS Advances in the Pharmaceutical Sciences Series, Volume 6) Hardcover7 approx. $209.00ISBN 978-1-4614-7977-2

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47

M. G. Kolonin, University of Texas, Houston, TX, USA (Ed)

Adipose Tissue and CancerRecent studies have shown that cells from adipose tissue are capable of trafficking to tumors, thus en-abling paracrine action of adipokines from within the tumor microenvironment. Increased tumor vascularization, immune system suppression and direct effects on malignant cell survival and pro-liferation have been investigated as mechanisms regulated by adipokines. The goal of this book is to discuss data pointing to the role of adipose tissue in cancer and to dissect individual mechanisms through which adipose tissue excess or restriction could influence cancer progression.

Features 7 Explores relationship between obesity and cancer 7 Examines direct effect of adipose tissue on cancer 7 Discusses role of endocrine signal-ing by adipose tissue-derived molecules in cancer promotion

Contents Preface: Obesity, Adipose Tissue and Cancer Progression.- Metabolic Perturbations Associ-ated with Adipose Tissue Dysfunction and the Obesity-Cancer Link.- Increased Adiposity and Colorectal Cancer.- Adiposity and Diabetes in Breast and Prostate Cancer.- Increased Adipoc-ity and Endometrial Cancer Risk.- Adipokines: Soluble Factors from Adipose Tissue Implicated in Cancer.- Animal Models to Study the Interplay between Cancer and Obesity.- Unraveling the local influence of tumor-surrounding adipose tissue on tumor progression: cellular and molecular actors involved.- Trafficking of Cells from Adipose Tis-sue to Tumor Microenvironment.- The Impact of Obesity Intervention on Cancer: Clinical Perspec-tives.- Index.

Fields of interestCancer Research; Lipidology; Cell Biology



Due July 2013


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D. M. Kolpashchikov, Y. V. Gerasimova, University of Central Florida, Orlando, FL USA (Eds)

Nucleic Acid DetectionMethods and Protocols

Contents “Getting Blood from a Stone”: Ultra-Sensitive Fo-rensic DNA Profiling of Microscopic Bio-particles Recovered from ‘Touch DNA’ Evidence.- Detect-ing MicroRNA in Human Cancer Tissues with Fluorescence in situ Hybridization.- MNAzyme qPCR: A Superior Tool for Multiplex qPCR.- A New, Multiplex, Quantitative Real-time Poly-merase Chain Reaction System for Nucleic Acid Detection and Quantification.- Detection of SNP-Containing Human DNA Sequences Using a Split Sensor with Universal Molecular Beacon Report-er.- SNP Analysis using a Molecular Beacon-based Operating Cooperatively (OC) Sensor.- Detection of rpoB Gene Mutations Using Helicase-Depen-dent Amplification.- Rapid Detection of Brucella spp. using Loop-mediated Isothermal Amplifica-tion (LAMP).- Loop-mediated Isothermal Ampli-fication Method for a Differential Identification of Human Taenia Tapeworms.- Detection of Muta-tion by Allele-specific Loop-mediated Isothermal Amplification (AS-LAMP).- DNA Detection by Cascade Enzymatic Signal Amplification.- Vi-sual DNA Detection and SNP Genotyping using Asymmetric PCR and Split DNA Enzymes.- De-tection of Single-stranded Nucleic Acids via Colo-rimetric Means, using G-quadruplex Probes.- Lat-eral Flow Biosensors for the Detection of Nucleic Acid.- Electrochemiluminescence Detection of c-Myc mRNA in Breast Cancer Cells on a Wireless Bipolar Electrode.- High-throughput Label-free Detection of DNA Hybridization and Mismatch Discrimination Using Interferometric Reflectance Imaging Sensor.- Graphene -PAMAM Dendrimer -Gold Nano Particle Composite for Electrochemi-cal DNA Hybridization Detection. [...]

Fields of interestHuman Genetics; Nucleic Acid Chemistry



Due July 2013

2013. XVI, 352 p. 83 illus., 56 in color. (Methods in Molecular Biology, Volume 1039) Hardcover7 $139.00ISBN 978-1-62703-534-7

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A. Kral, Hannover Medical School, Germany; A. N. Popper, University of Maryland, College Park, MD, USA; R. R. Fay, Marine Biological Laboratory, Woods Hole, MA, USA (Eds)

Deafness Features 7 Considers deafness as a medical condi-tion 7 Explores the neuronal consequences on the peripheral and the central nervous system as well as on cognition and learning 7 Written from the standpoint of genetics, neuroanatomy and neurophysiology, molecular biology, systems neuroscience, and cognitive neuroscience

Contents 1. To Hear or Not To Hear: Neuroscience of Deafness Andrej Kral.- 2. Molecular Etiology of Deafness and Cochlear Consequences Zippora Brownstein, Shaked Shivatzki, and Karen B. Avraham.- 3. Effects of Early-Onset Deafness in the Developing Auditory System Patricia A. Leake, Olga Stakhovskaya, and Stephen J. Rebscher.- 4. Synaptic Organization and Plasticity in the Audi-tory System of the Deaf White Cat Michael A. Muniak, Catherine J. Connelly, Natasha N. Tirko, Jahn N. O’Neil, and David K. Ryugo.- 5. Synaptic and Cellular Consequences of Hearing Loss Dan H. Sanes.- 6. Integrative Neuronal Functions in Deafness Andrej Kral, Peter Baumhoff, and Robert K. Shepherd.- 7. The Impact of Deafness on the Human Central Auditory and Visual Systems Anu Sharma and Teresa Mitchell.- 8. Multisensory In-teractions in Auditory cortex and Auditory Reha-bilitation in Deafness Diane S Lazard, Anne-Lise Giraud, and Pascal Barone.- 9. Visual Attention in Deaf Humans: A Neuroplasticity Perspective Matthew W. G. Dye and Daphne Bavelier.- 10. The Consequences of Deafness for Spoken Language Development Peter J. Blamey and Julia Z. Sarant.

Field of interestNeurosciences

Target groupsGraduate


Due August 2013

2014. Approx. 300 p. (Springer Handbook of Auditory Research, Volume 47) Hardcover7 approx. $139.00ISBN 978-1-4614-7839-3

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48

New SeriesPerspectives in PhysiologyThis fascinating series seeks to place medical science inside a greater historical framework, describing the main pathways of development and highlighting the contributions of prominent investigators

L. D. Longo, Loma Linda University School of Medicine, CA, USA

The Rise of Fetal and Neonatal PhysiologyBasic Science to Clinical Care

Contents Introduction.- A Scientific Genealogy: The Devel-opment of Fetal-Neonatal Research.- Oxford and the Development of Physiology, with Notes on the Nuffield Institute.- Geoffrey S. Dawes: A Life in Science.- Dawes and Fetal Asphyxia: The Primate Colony in Puerto Rico.- Dawes, the Pulmonary Vasculature and his Foetal and Neonatal Physiol-ogy.- Embryology and Early Developmental Physiology.- Some Aspects of the Physiology of the Placenta.- Governmental Support of Research in Fetal and Newborn Physiology.- Fetal-Neonatal Growth and Metabolism.- Epigenetics and the Fetal Origins of Adult Heath and Disease.- Related Developments in Fetal and Neonatal Endocrinol-ogy.- Further Developments in Fetal and Neonatal Physiology.- Some Clinical Aspects of Develop-mental Physiology.- Bioethical Issues in Research on the Fetus and Newborn Infant.- Textbooks, Monographs and other Volumes on Fetal and Newborn Physiology.- Dawes and Fetal “Breath-ing” in the 1970s, and Fetal Heart Rate Analysis in the 1980s and early 1990s.- Dawes’ Contribu-tions to Symposia and a Summing Up.- Dawes as a Mentor: Reminisces of Former Graduate Students, Postdoctoral Fellows, and Associates.- Early Years of the Society for Gynecologic Investigation, the Fetal and Neonatal.- Epilogue.- Index.

Fields of interestHuman Physiology; History of Medicine; Repro-ductive Medicine



Due August 2013

2014. XII, 416 p. 55 illus., 19 in color. (Perspectives in Physiology, Volume 1) Hardcover7 $209.00ISBN 978-1-4614-7920-8

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S. Makovets, University of Edinburgh, UK (Ed)

DNA ElectrophoresisMethods and Protocols

Contents DNA Electrophoresis: Historical and Theoreti-cal Perspectives.- Basic DNA Electrophoresis in Molecular Cloning: a Comprehensive Guide for Beginners.- Analysis of Branched DNA Replica-tion and Recombination Intermediates from Prokaryotic Cells by Two-dimensional (2D) Native-native Agarose Gel Electrophoresis.- Analysis of DNA Structures from Eukaryotic cells by Two-dimensional Native-native DNA Agarose Gel Electrophoresis.- Directionality of Replication Fork Movement Determined by Two-dimensional Native-native DNA Agarose Gel Electrophore-sis.- Native/Denaturing Two-Dimensional DNA Electrophoresis And Its Application To The Analysis Of Recombination Intermediates.- Plas-mid DNA Topology Assayed by Two-dimensional Agarose Gel Electrophoresis.- A Neutral Glyoxal Gel Electrophoresis Method for the Detection and Semi-Quantitation of DNA Single-Strand Breaks.- Denaturing Gradient Gel Electrophoresis (DGGE).- Polyacrylamide Temperature Gradi-ent Gel Electrophoresis.- Separation of DNA Oligonucleotides using Denaturing Urea-PAGE.- Pulsed-field Gel Electrophoresis of Bacterial Chromosomes.- Resolution of Budding Yeast Chromosomes using Pulse Field Gel Electropho-resis.- Analysis of DNA Damage Via Single Cell Electrophoresis.- Fluorescence in situ Hybridisa-tion on Electrophoresed Cells to Detect Sequence Specific DNA Damage.- Analysis of Protein-DNA Interactions using PAGE: Band-shift Assays.- As-saying Cooperativity of Protein-DNA Interactions using Agarose Gel Electrophoresis.- DNA Bending by Proteins: Utilizing Plasmid pBendAT as a Tool. [...]

Fields of interestHuman Genetics; Electrophoresis



Due July 2013


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49

A. Malek, N.N Petrov Institute of Oncology, St. Petersburg, Russia; O. Tchernitsa, Charité - Universitatsmedizin Berlin, Germany (Eds)

Ovarian CancerMethods and Protocols

Contents Ovarian Cancer Genome.- Identifying Associa-tions Between Genomic Alterations in Tumours.- Analysis of Genome-wide DNA Methylation Profiles by BeadChip Technology.- Integrative Prediction of Gene Function and Platinum Free Survival from Genomic and Epigenetic Features in Ovarian Cancer.- Survival Prediction Based on In-herited Gene Variation Analysis.- Main Principles and Outcomes of DNA Methylation Analysis.- Methylation-specific PCR.- Bisulfite Sequencing of Cloned Alleles.- Bisulfite Pyrosequencing.- RNA Networks in Ovarian Cancer.- Microarray-based Transcriptome Profiling of Ovarian Cancer Cells.- Deep Transcriptome Profiling of Ovarian Cancer Cells using Next Generation Sequencing Approach .- Assessment of mRNA Splice Variants by qRT-PCR.- Micro-RNA Profiling in Ovarian Cancer.- Detailed Analysis of Promoter-associated RNA.- Integrating Multiple Types of Data to Identify MicroRNA-gene Co-modules.- Energy Metabolism and Changes in Cellular Composi-tion in Ovarian Cancer.- Metabolomic Profiling of Ovarian Carcinomas using Mass Spectrom-etry.- Choline Metabolic Profiling by Magnetic Resonance Spectroscopy.- Proteomic Profiling of Ovarian Cancer Models using TMT-LC-MS/MS.- Characterization of Signalling Pathways by Reverse Phase Protein Arrays.- N-Glycosylation Analysis by HPAEC-PAD and Mass Spectrom-etry.- In vivo and in vitro Properties of Ovarian Cancer Cells.- Establishment of Primary Cultures from Ovarian Tumour Tissue and Ascites Fluid.- Ovarian Cancer Stem Cells Enrichment. [...]

Fields of interestCancer Research; Oncology



Due July 2013


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J. Mamou, Riverside Research Institute, New York, NY, USA; M. L. Oelze, University of Illinois at Urbana-Champaign, IL, USA (Eds)

Quantitative Ultrasound in Soft Tissues Features 7 Comprehensive state of the art review of quantitative ultrasound methods in tis-sues 7 Novel review of ultrasonic backscatter estimation 7 Large set of clinical applications of quantitative ultrasound

Contents State of the art methods for estimating the backscatter coefficients.- Quantitative Ultrasound History and Successes.- Statistics of Scatterer Property Estimates.- Attenuation Compensation and Estimation.- Quantitative Ultrasound and Cell Death.- Modeling of Ultrasound Backscatter-ing by Aggregating Red Blood Cells.- Backscatter Quantification for the Detection of Metastatic Regions in Human Lymph Nodes.- Quantita-tive Ultrasound for Tissue-type Imaging of the Prostate: Implications for Planning and Guid-ing Biopsies and Focal Treatments.- Therapy Monitoring and Assessment Using Quantitative Ultrasound.- Review of Envelope Statistics Models for Quantitative Ultrasound Imaging and Tissue Characterization.- The Quantitative Ultrasound Diagnosis of Liver Fibrosis Using Statistical Analysis of the Echo Envelope.- Recent Applica-tions of Acoustic Microscopy for Quantitative Measurement of Acoustic Properties of Soft Tissues.- Acoustic Microscopy of Cells.- Methods for Forward and Inverse Scattering in Ultrasound Tomography.- Clinical Results with Ultrasound Computed Tomography of the Breast.

Fields of interestBiomedicine general; Signal,Image and Speech Processing; Acoustics



Due July 2013

2013. XVI, 481 p. 172 illus., 104 in color. Hardcover7 $209.00ISBN 978-94-007-6951-9

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A. Masoudi‑Nejad, Z. Narimani, N. Hosseinkhan, University of Tehran, Iran

Next Generation Sequencing and Sequence AssemblyMethodologies and Algorithms

The goal of this book is to introduce the biological and technical aspects of next generation sequenc-ing methods, as well as algorithms to assemble these sequences into whole genomes. The book is organized into two parts; part 1 introduces NGS methods and part 2 reviews assembly algorithms and gives a good insight to these methods for readers new to the field. Gathering information, about sequencing and assembly methods together, helps both biologists and computer scientists to get a clear idea about the field. Chapters will include information about new sequencing technologies such as ChIp-seq, ChIp-chip, and De Novo sequence assembly.

Features 7 This book introduces sequencing and assembly from a biological aspect as well as an algorith-mic point of view 7 Suited for researchers with biological backgrounds and mathematical backgrounds 7 Focuses on methodologies and algorithms of next generation sequencing and sequence assembly

Contents Preface.- Next generation sequencing methodolo-gies.- Emergence of next generation sequencing.- Assembly of sequencing data.- De novo assembly algorithms.- Index.

Fields of interestHuman Genetics; Systems Biology; Biomedicine general



Due June 2013

2013. X, 99 p. 46 illus., 43 in color. (SpringerBriefs in Systems Biology, Volume 4) Softcover7 $49.99ISBN 978-1-4614-7725-9

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50

A. Meissner, Harvard University, Cambridge, MA, USA; J. Walter, Saarland University, Saarbrücken, Germany (Eds)

Epigenetic Mechanisms in Cellular ReprogrammingThis volume provides an overview on current top-ics and concepts concerning the mechanisms and consequences of epigenetic reprogramming.

Features 7 Contains translational medicine aspects such as B cell programming and reprogramming in cancer 7 Includes extensive glossary 7 Under-standing stem cell formation is key to develop novel drugs

Contents Preface Part I Germ cell and early embryo (epigenetic) programs: Histone variants early reprogramming Control of germ line development and reprogramming DNA-methylation dynamics in early mouse embryos The oocyte determinants of early reprogramming The sperm epigenome and early development CpG island methylation in oocytes and early embryos Stella and zygotic reprogramming Part II Direct reprogramming of somatic cells and iPS reprogramming Small RNAs and reprogramming Epigenomes of iPS cells Pathways for direct reprogramming Part II Epigenetic control of ES cells Role of pluripotency factors in X-chromosome silencing Modulation of epigenetic cell states in ES cells TDG and control of epigenetic identity in ESCs The role of novel DNA-modifications in stem cells Epigenomics of stem cell programmes Part IV Epigenetic control of somatic stem cell identity Epigenetic mainte-nance of pluripotency by polycomb group proteins Function of Mi-NuRD in B cell programming Epi-genetic reprogramming in cancer Glossary Index

Fields of interestHuman Genetics; Cell Biology; Systems Biology



Due January 2014

2014. Approx. 250 p. 70 illus., 20 in color. (Epigenetics and Human Health) Hardcover7 approx. $209.00ISBN 978-3-642-31973-0

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J. L. Millán, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA (Ed)

Phosphatase ModulatorsFeatures 7 Serves as a "how to" manual for the initiation of drug discovery efforts 7 Provides step-by-step detail essential for reproducible results 7 Con-tains key tips and implementation advice from the experts

Contents Chemical Probe Development Versus Drug Devel-opment.- Phosphatase High-Throughput Screen-ing Assay Design and Selection.- Multisystemic Functions of Alkaline Phosphatases.- Robotic Implementation of Assays: Tissue-Nonspecific Alkaline Phosphatase (TNAP) Case Study.- In-hibitors of Tissue-Nonspecific Alkaline Phos-phatase (TNAP): From Hits to Leads.- A Method for Direct Assessment of Tissue-Nonspecific Alkaline Phosphatase (TNAP) Inhibitors in Blood Samples.- Isolation and Characteristics of Matrix Vesicles.- The Use of Tissue-Nonspecific Alkaline Phosphatase (TNAP) and PHOSPHO1 Inhibitors to Affect Mineralization by Cultured Cells.- Modulators of Intestinal Alkaline Phos-phatase.- New Activity Assays for ENPP1 with Physiological Substrates ATP and ADP.- Structure of Acid Phosphatases.- Purification of Prostatic Acid Phosphatase (PAP) for Structural and Func-tional Studies.- Protein Tyrosine Phosphatases: Structure, Function, and Implication in Human Disease.- High-Throughput Screening for Protein Tyrosine Phosphatase Activity Modulators.- Eval-uating Effects of Tyrosine Phosphatase Inhibitors on T Cell Receptor Signaling.- Interactor-Guided Dephosphorylation by Protein Phosphatase-1.- Structure, Regulation, and Pharmacological Modulation of PP2A Phosphatases.

Fields of interestPharmacology/Toxicology; Medicinal Chemistry; Pharmacy



Due July 2013


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P. Nguyen, University of Alberta, Edmonton, AB, Canada (Ed)

Multidisciplinary Tools for Investigating Synaptic Plasticity Contents Conditional Gene Targeting: A Refined Method for Genetic Studies in Neurosciences.- Sindbis Virus-Mediated In Vivo Expression of Recombi-nant CREB to Study Gene Function in Neuronal Plasticity and Behavior.- Exploring Mechanisms of Synaptic Plasticity Using Exogenous Expression of Proteins at the Sensory-to-Motor Neuron Synapse of Aplysia.- Translational Regulation of Synaptic Plasticity.- Glutamate Receptors and Synaptic Physiology in Developing Neural Circuits.- Lami-nar Quantification of Dendrites in Dentate Gyrus Granule Neurons.- Electrophysiological and Bio-chemical Studies of AMPA Receptor Phosphoryla-tion and Synaptic Plasticity in Hippocampal CA1 Mini-Slices.- Electrophysiological and Behavioral Approaches to the Analysis of Synaptic Tagging and Capture.- Intracellular Loading and Rapid Calcium Imaging in Processes of Hippocampal Astrocytes.- Electrophysiological Methods for Investigating Inhibitory Synaptic Plasticity.- Con-verging Methodologies in a Mammalian ‘Simple System’ Focused on the Biology of Memory: Con-ditioned Odor Preference in the Neonate Rat.- The Sagittally-Sectioned Rat Hindbrain Preparation: Improved Access to the Brainstem Respiratory Network.

Fields of interestNeurosciences; Human Physiology; Neurochem-istry



Due July 2013

2013. XII, 430 p. 55 illus., 27 in color. (Neuromethods, Volume 81) Hardcover7 $119.00ISBN 978-1-62703-516-3

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51

J. M. Ntambi, Ph.D., University of Wisconsin-Madison, WI, USA (Ed)

Stearoyl-CoA Desaturase Genes in Lipid MetabolismObesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of mono-unsaturated fatty acids (MUFA), mainly oleoyl- (18:1n9) and palmitoleoyl-CoA (16:1n7). These MUFAs are the major fatty acid substrates for the synthesis of triglycerides, cholesterol esters, wax esters and membrane phospholipids.

Features 7 First book to focus on SCD Genes in Lipid Metabolism 7 This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver, metabolism, Colitis, and more 7 Gives an overview of the growth of re-search on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species

Contents SCD genes of fatty acid synthesis.- SCD genes in heart metabolism.- SCD genes in liver metabo-lism.- SCD genes in harderian and perpetual glands.- SCD genes In lipogenesis.- SCD genes lipoproteins.- SCD genes in WAT.- SCD genes in muscle.- SCD genes in the brain.- SCD genes in inflammation.- SCD genes in ER Stress.- SCD genes in skin.- SCD genes in insulin signal-ing.- SCD genes in thermogenesis.- SCD genes in diabetes.- SCD genes atherosclerosis.- SCD genes in Adipocyte differentiation.- SCD genes and epi-genetics.- SCD genes in fatty liver disease.- SCD genes in Colitis.- SCD genes in leptin signaling.

Fields of interestHuman Genetics; Endocrinology; Lipidology



Due July 2013

2013. XII, 408 p. 42 illus., 24 in color. Hardcover7 $189.00ISBN 978-1-4614-7968-0

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H. Ogawa, Hokkaido University, Japan; K. Oka, Keio University, Japan (Eds)

Methods in Neuroethological ResearchThe rapid progress of neuroscience in the last decade can be largely attributed to significant advances in neuroethology, a branch of sci-ence that seeks to understand the neural basis of natural animal behavior. Novel approaches including molecular biological techniques, opti-cal recording methods, functional anatomy, and informatics have brought drastic changes in how the neural systems underlying high-level behav-iors such as learning and memory are described. This book introduces recent research techniques in neuroethology, with diverse topics involving nematodes, insects, and vertebrates (birds, mice and primates), divided into sections by research method. Each section consists of two chapters written by different authors who have devel-oped their own unique approaches. Reports of research in “model animals” including C. elegans, Drosophila, and mice, which were not typical specimens in conventional neuroethology, have been deliberately selected for this book because a molecular genetic approach to these animals is necessary for advances in neuroethology.

Features 7 Easy-to-follow protocols and tangible advices help the reader to put experiments into practice quickly 7 Variety of applications of leading-edge research techniques extend the readers’ scope of the experimental approach 7 Wide range of topics on various species of materials including non-model animals with unique behaviors guide the readers to modern neuroethology

Fields of interestNeurosciences; Neurochemistry; Systems Biology



Due June 2013

2013. XII, 208 p. 41 illus., 26 in color. Hardcover7 $189.00ISBN 978-4-431-54330-5

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S. Pöhlmann, Hannover Medical School, Germany; G. Simmons, University of California, San Francisco, CA, USA (Eds)

Viral Entry into Host CellsFor a virus to invade a host cell it needs to pen-etrate the physical barrier imposed by the plasma membrane. Viruses have evolved specialized sur-face proteins to meet this challenge. These proteins facilitate delivery of the viral genetic informa-tion into the host cell by either fusing the viral envelope with a host cell membrane or by forming membrane pores. Membrane fusion and pore formation critically depend on the engagement of host cell receptors and receptor choice is a key determinant of viral tropism. The multi-faceted interplay between viral and cellular factors during virus entry is a fascinating field of study, which can provide important insight into viral pathogen-esis and define new targets for intervention. This book provides a comprehensive overview of this exciting field of research.

Features 7 Provides a comprehensive overview of inter-play between viral and cellular factors during virus entry 7 Reviews key processes underlying host cell entry of viruses 7 Discusses cellular entry of reoviruses

Contents Attachment Factors.- Picornavirus Entry.- Reo-virus Receptors, Cell Entry, and Proapoptotic Signaling.- Entry of Influenza Virus.- Filovirus Entry.- Paramyxovirus Entry.- Cellular entry of retroviruses.- Class II Fusion Proteins.- Entry of Rhabdoviruses into Animal Cells.- Entry of Her-pesviruses into Cells: The Enigma Variations.

Fields of interestBiomedicine general; Cell Biology



Due August 2013

2013. XVIII, 200 p. 38 illus., 14 in color. (Advances in Experimental Medicine and Biology, Volume 790) Hardcover7 approx. $189.00ISBN 978-1-4614-7650-4

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52

L. J. Robertson, Norwegian School of Veterinary Science, Oslo, Norway

Giardia as a Foodborne PathogenAlthough widely recognized as an important wa-terborne pathogen, Giardia duodenalis can also be transmitted by contamination of food. The same properties of this protozoan parasite that mean that water is an excellent transmission vehicle are also important for foodborne transmission. These include the low infective dose, the high number of cysts that are excreted, and the robustness of these transmission stages. However, many more outbreaks of waterborne giardiasis have been reported than foodborne outbreaks. This is prob-ably partly due to epidemiological tracing being much more difficult for foodborne outbreaks than waterborne outbreaks, and the number of persons exposed to infection often being fewer. Neverthe-less, the potential importance of foodborne trans-mission is gradually being recognized, and a wide range of different foodstuffs have been associated with those outbreaks that have been recorded.

Contents Introduction to the parasite: biology (includ-ing species and genotypes), lifecycle, pathology, treatment.- Transmission routes and factors that lend themselves to foodborne transmission.- Documented foodborne outbreaks.- Approaches to detecting Giardia cysts in different food matrices.- Occurence of Giardia cysts in different food matrices: results of surveys.- Inactivation or decontamination procedures.- Risk assessment and regulations.- Future challenges.- Conclu-sions.- References.

Fields of interestParasitology; Food Science



Due June 2013

2013. X, 52 p. 1 illus. (SpringerBriefs in Food, Health, and Nutrition) Softcover7 $49.99ISBN 978-1-4614-7755-6

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T. Rogers, G. J. Criner, Temple University School of Medicine, Philadelphia, PA, USA; W. Cornwell, Temple University, Philadelphia, PA, USA (Eds)

Smoking and Lung InflammationBasic, Pre‑Clinical and Clinical Research Advances

Smoking and Lung Inflammation is the first book directly related to chronic lung inflammation of its kind in several respects. First, the it focuses on both basic and clinical research on COPD, and the inflammatory mechanisms that function in these diseases.

Features 7 Focus on both basic and clinical re-search 7 Unique, with respect to scope of the discussion of the unusual characteristics of the im-mune response in patients 7 Will include knowl-edge being gained from translational research

Contents Introduction.- Immunopathology of COPD.- Monocyte Populations Which Participate in Chronic Lung Inflammation.- Neutrophils Inflammation in COPD.- Role of Epithelial Cells in Chronic Inflammatory Lung Disease.- The Relationship Between Oxidative Stress Responses and Lung Inflammation with Cigarette Smok-ing.- Autoimmune Mechanisms Contributing to Chronic Obstructive Pulmonary Disease.- Chron-ic Obstructive Pulmonary Disease (COPD): Local and Systemic Disease.- Infectious Mechanisms Regulating Susceptibility to Acute Exacerbations of COPD.- COPD: Biomarkers and Phenotypes.- Anti-inflammatory Therapeutics in COPD: Past, Present and Future.

Fields of interestImmunology; Pneumology/Respiratory System; Pathology

Target groupsGraduate


Due July 2013

2013. II, 190 p. 21 illus. in color. Hardcover7 $189.00ISBN 978-1-4614-7350-3

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A. Sedo, R. Mentlein (Eds)

Glioma Cell BiologyGliomas are fatal diseases, but also represent good models for tumor research with the aim to eventu-ally discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorigen-esis (tumor stem cell theory versus “classical” opinions), tumor angiogenesis (since they are highly vascularized) and tumor invasion (since they grow without limits). In addition, they have a very special microenvironment (the brain) and limited tumor stroma cells (mainly microglia and endothelial cells).

Features 7 Covers genetic, epigenetic, cell- and molecular biology of glioma cells. 7 Depicts the cell-cell interaction of glioma cells with their environ-ment. 7 Presents experimental research models for glioma research

Contents Genetic Alterations, Diversity/Heterogneity and Expression Profiling in Gliomas.- Epigenetic Changes in Gliomas.- miRNAs in the Patho-genesis of Gliomas.- Signaling Cascades and Transcription Factors Driving the Malginant Phenotype of Glioma Cells.- Glioma Associated Proteases.- Mitochondrially - Mediated Apoptosis in Glioma Cells.-Adhesion Molecules and their Role in Glioma Invasion.- Autophagy in Glioma Cells.- Auto- and Paracrine Mediators in the Glioma Microenvironment.- Glioma Extracellular Matrix.- Autophagy in Glioma Cells.- Glioma Stem Cells and Their Niche.- Immune Response - Glioma Associated Immnosuppression.- Microglia a Friend or Foe?.- Angiogenensis in Gliomas.- Glioma Heterogeneity.- Exprimental Models of Glioma.- Models for the Study of Glioma Cell Invasion.

Fields of interestNeurosciences; Oncology; Molecular Medicine



Due September 2013

2014. Approx. 500 p. 80 illus., 40 in color. Hardcover7 approx. $239.00ISBN 978-3-7091-1430-8

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53

K. Selvarajoo, Keio University, Yamagata, Japan

Immuno Systems BiologyA macroscopic approach for immune cell signaling

Immuno Systems Biology aims to study the im-mune system in the more integrated manner on how cells and molecules participate at different system levels to the immune function. Through this book Kumar Selvarajoo introduces to physi-cists, chemists, computer scientists, biologists and immunologists the idea of an integrated approach to the understanding of mammalian immune system.

Features 7 Immuno systems biology specifically aims to study the host immune system in a more integrat-ed manner 7 Focuses on the dynamical analyses of mammalian innate immune response to bacte-rial and viral perturbations using computational models based on simple physical rules 7 Deals with interpreting population level immune cell signaling response in wildtype and mutant cells

Contents Preface.- Systems biology of population cell response.- Perturbation-response approach for biological network analysis.- Basics of the mam-malian immune system.- Inferring novel features of the TLR4 pathways.- Signaling Flux Redistribu-tion.- Investigating the TLR3 signaling dynam-ics.- Understanding TNFR1 signaling dynam-ics.- TRAIL signaling in cancer.- Stochasticity and variability: insights from single cell dynamics.- Investigating single cell stochasticity in TRAIL signaling.- The distinction between single cell and population dynamics.- Finding chaos in biology.- Concluding remarks.- Index.

Fields of interestBiomedicine general; Systems Biology; Bioinfor-matics



Due July 2013

2013. IV, 178 p. 68 illus., 60 in color. (Systems Biology, Volume 3) Hardcover7 $139.00ISBN 978-1-4614-7459-3

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M. A. Tabrizi, AnaptysBio, Inc., San Diego, CA, USA; I. Figueroa, Merck & CO Inc., Palo Alto, CA, USA

Surrogate Approaches in Development of Antibody-Based TherapeuticsA Quantitative Evaluation

Feature 7 Examines many important considerations necessary for the design of most effective as well as science-based translational strategies necessary for the successful development of antibody-based therapeutics when surrogate approaches are employed

Fields of interestPharmacology/Toxicology; Biochemistry, general; Pharmacy



Due June 2013

2013. 400 p. Hardcover7 approx. $189.00ISBN 978-1-4419-5776-4

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G. Tridente, University of Verona, Italy

Adverse Events of BiomedicinesThis monograph collects and evaluates data on adverse events (AEs) due to biomedicines, a new class of drugs in use for human therapy. It is a practical guideline to a new area demanding the attention of clinicians, immunologists, oncolo-gists, allergologists, public health professionals, and drug companies. Definition, classification, and major features of each drug are related to typologies of AEs observed during pre- and post-licensing trials and studies, as well as to spontane-ous reporting.

Features 7 Synthetic and unique publication on adverse events of a new and fast-growing class of medi-cines 7 Multidisciplinary interest (biomedical, public health, biologics producers for human therapy) 7 Downloadable database enclosed for rapid multi-entry search and consultation

Contents 1. Biomedicines: Definition, Classification, Mono-clonal Antibodies, Soluble Receptor Analogues, Cytokines Chemokines, Growth Factors, Anti-receptor drugs.- 2. Adverse Events: Definition, Classification,Typology.- 3. Adverse Events to Biomedicines: by System Organ Classification/Class of drugs, Systemic acute syndromes (CRS, TLS, CLS), Data Sheets: significance and use.- 4. AEs and Immunogenicity of Biologicals.- 5. AEs in pre- and post-licensing observations, The post-marketing mix: REMS, Trials and SAERS. Data comparing importance and difficulties.-6. AEs in off-label treatments.- 7. Attempting an etiolgical picture of AEs to Biomedicines.- 8. Efficacy vs AEs induction.- 9. Lessons for safer future Bio-medicines.- 10. Appendix (Data Sheets).

Fields of interestBiomedicine general; Medicine/Public Health, general; Pharmacy



Due September 2013

2014. Approx. 250 p. 60 illus. Hardcover7 approx. $189.00ISBN 978-88-470-5312-0

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E. J. Van Bockstaele, Thomas Jefferson University, Philadelphia, PA, USA (Ed)

Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological DisordersFeatures 7 Content written by the leading experts in the field 7 Presents potential therapeutic applica-tions 7 Most up-to-date information available

Contents Endocannabinoids and monoamines: modulat-ing the modulators.- Endocannabinoid-mediated synaptic plasticity.- Current cannabinoid receptor nomenclature and pharmacological principles.- Cue-elicited craving for cannabis activates the reward neurocircuitry associated with the neuro-pathology of addiction.- Cannabinoid modulation of dopaminergic circuits in neurodegenerative and neuropsychiatric disorders.- Pathophysiol-ogy of mood disorders and mechanisms of action of antidepressants and mood stabilizers.- Ana-tomical, biochemical and behavioral evidence for cannabinoid modulation of noradrenergic circuits: role of norepinephrine in cannabinoid-induced aversion.- Gender Disparity of Depression: The Role of Endocannabinoids and Noradrenergic Function.- Endocannabinoids, Monoamines and Stress.- Chronic effects of cannabinoid drugs on monoaminergic systems and the role of endocan-nabinoids and cannabinoid receptors in human brain disorders.- Endocannabinoid Signaling and the Regulation of the Serotonin System.- Modu-lation of serotonin firing activity through CB1 agonists and FAAH inhibitors.- Involvement of serotonergic system in cannabinoid analgesia.- Cannabinoids, monoamines, COMT and schizo-phrenia: pathobiological mechanisms in psychosis.

Fields of interestNeurosciences; Neurology; Psychiatry



Due July 2013

2013. VI, 537 p. 26 illus., 7 in color. Hardcover7 $209.00ISBN 978-1-4614-7939-0

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W. Wu, University of Calgary, AB, Canada; H. Choudhry, University of Oxford, UK (Eds)

Next Generation Sequencing in Cancer ResearchVolume 1: Decoding the Cancer Genome

Contents Introduction: next generation sequencing technol-ogy and cancer research.- The majority of total nuclear-encoded non-ribosomal RNA in a human cell is ‘dark matter’ unannotated RNA.- Total RNA-seq of breast cancer in hypoxia.- Altered antisense-to-sense transcript ratios in breast cancer.- Identification of piRNAs in Hela cells by massive parallel sequencing.- Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia.- Whole-Exome Sequencing Identifies FAM20A Muta-tions as a Cause of Amelogenesis Imperfecta and Gingival Hyperplasia Syndrome.- Whole-exome sequencing in CIC and IDH1/2 contributing to human oligodendroglioma.- Genetic and structur-al variation in the gastric cancer kinome revealed through targeted deep sequencing.- Tumour evolution inferred by single-cell sequencing.- Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq.- Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNASeq analysis.- Whole genome DNA methylation analysis based on high throughput sequencing technology.- Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors.- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.- MicroRNA transfection and AGO-bound CLIP-seq data sets reveal distinct determinants of miRNA action.- Genome-wide identification of polycomb-associated RNAs by RIP-seq. [...]

Fields of interestCancer Research; Bioinformatics; Human Genet-ics



Due July 2013


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T. Yamamura, National Center for Neurology and Psychiatry, Tokyo, Japan; B. Gran, University of Nottingham, UK (Eds)

Multiple Sclerosis Immunology Contents Th17 cells in autoimmune inflammation and de-myelination in the central nervous system.- Regu-latory T cells in MS.- T-bet: A critical regulator of encephalitogenic T Cells.- Antigen-presenting cells in the Central Nervous System.- The role of B cells in multiple sclerosis.- Diet, gut flora and multiple sclerosis: current research and future perspectives.- GM-CSF in autoimmune inflam-mation of the central nervous system.- The role of Toll-like receptors in multiple sclerosis and experimental autoimmune encephalomyelitis.- Macrophages and microglia in experimental auto-immune encephalomyelitis and multiple sclerosis.- Genetics of multiple sclerosis.- Gene expression profiling and pathway analysis for identification of molecular targets in MS.- Systems biology for the study of multiple sclerosis.- Checkpoints in the de-velopment of pathogenic and regulatory T cells in Experimental Autoimmune Encephalomyelitis—a basis for current future interventions in MS.- Modeling MS in non-human primates.- A novel concept of treatment in MS: targeting both oligo-dendrocyte death and inflammatory processes by inhibiting poly (ADP-Ribose) polymerase.- As-sociation of MS with other autoimmune dis-eases.- Current and future treatments of Multiple Sclerosis.- Targeting CD52 for the treatment of Multiple Sclerosis.- Haematopoietic stem cells for the treatment of MS.- Mesenchymal stem cells for the treatment of Multiple Sclerosis.

Fields of interestImmunology; Gene Function; Molecular Medicine



Due August 2013

2014. II, 387 p. 47 illus., 37 in color. Hardcover7 approx. $209.00ISBN 978-1-4614-7952-9

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Autoimmune Disease Genetic Damage in Human Pathogenesis ... › sgw › documents › 1398471 ›...

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