Australian Centre for NanoMedicine Annual Report 2015 · Professor Merlin Crossley, Dean of...

Australian Centre for NanoMedicine Annual Report 2015

Never Stand Still Australian Centre for NanoMedicine

Australian Centre for NanoMedicine | Annual Report 2015 | 2

Table of Contents

Directors’ Report .................................................................................................................................. 3

Centre Information .............................................................................................................................. 4

Mission and Vision Statements ....................................................................................................... 5

Organisational Chart ........................................................................................................................... 6

ACN Affiliated Staff and Students .................................................................................................. 7

Steering Committee .......................................................................................................................... 10

Highlights of Member Achievements ....................................................................................... 11

Member Profiles ................................................................................................................................. 15

High Impact Papers ........................................................................................................................... 16

Centre Activity Highlights .............................................................................................................. 18

6th International NanoMedicine Conference .................................................................. 18

Clinician Outreach ..................................................................................................................... 19

Seed Funding Program ............................................................................................................ 20

Postgraduate Student Projects .................................................................................................... 21

Research Student Profiles .............................................................................................................. 25

Collaborating Organisations ......................................................................................................... 26

ACN Member Grants ......................................................................................................................... 28

Awards and Honours ....................................................................................................................... 30

Conference Papers and Presentations ...................................................................................... 35

Publications .......................................................................................................................................... 38

Financial Summary ........................................................................................................................... 46


Directors’ Report

Nanomedicine is the science of developing new healthcare breakthroughs that are designed and constructed on the nanometer scale (the nanoscale). The nanoscale is incredibly small – one nanometer (nm) is one-billionth of a metre, to put this in context, imagine the size difference between a marble and the earth.

The Australian Centre for NanoMedicine commenced at the University of

New South Wales (UNSW) in 2011. Our unique research centre incorporates researchers from UNSW’s faculties of Engineering, Medicine

and Science and our strategic vision is to create teams focused on particular diseases using Team ACN’s skills in drug delivery, diagnostics and imaging. Over the past 5 years, our Centre has clearly established itself to be one of the world leaders in this research/medical discipline. In this 2015 Annual Report we reflect over the last twelve months with much pride on our research achievements and how the work of our 100+ team is impacting from our research benches, all the way to clinical bedside. The Centre‘s mission remains to provide solutions to clinical challenges in medicine through world leading interdisciplinary researchers in diagnostics and therapeutic delivery. Team ACN continues to work on diseases including neuroblastoma, lung, blood and pancreatic cancers, while diabetes, asthma and uveitis are part of our non-cancer portfolio. Our skills in drug delivery, imaging agents and diagnostic devices are producing world-leading outcomes reflected in our strong publication record in 2015. Total research funding of the Centre’s team members through Australian/State Governments, cancer institutes, industry collaboration and other funding sources reached record level in 2015 with the expectation of further growth in 2016. The 6th International Nanomedicine Conference was again a great success welcoming more than 240 attendees from 19 countries. Highlights included the wonderful plenary speakers, Professor Tariq Rana (University of California, Davis), Professor Paula Hammond (Massachusetts of Technology), Professor Leaf Huang (University of North Carolina), Professor Gordon Wallace (University of Wollongong) and Associate Professor Stephen Rose (CSIRO). To heighten NanoMedicine awareness to high school students, we invited science students from St. Aloysius’ College to attend the conference and judge poster presentations following the success of last year’s high school program. We would also like to take this opportunity to thank Senior DVC Professor Les Field, DVC (Education) Professor Merlin Crossley, Dean of Engineering Professor Mark Hoffman, Dean of Science Professor Peter Lovibond, Dean of Medicine Professor Rodney Phillips, and Steering Committee member Scientia Professor Ian Dawes for their continued support of the Centre. We commend to you this report on our activities and events and we look forward to reporting on more exciting research and successes in the future.

PROFESSOR MARIA KAVALLARIS || SCIENTIA PROFESSOR JUSTIN GOODING Co-Director Co-Director


Centre Faculties and Associate Organisations

The Australian Centre for NanoMedicine is a unique Centre in that it draws members from several faculties, schools, institutes and centres across UNSW.

Presiding Faculty - Faculty of Engineering Associate Faculties - Faculty of Science Faculty of Medicine Faculty of Arts and Social Sciences Host School - School of Chemical Engineering Associate Schools - School of Chemistry School of Medical Sciences School of Humanities and Languages School of Women’s and Children’s Health School of Mechanical and Manufacturing Engineering Associate Institute - Children’s Cancer Institute Australia Associate Centre - Mark Wainwright Analytical Centre


Mission of the ACN

The Australian Centre for NanoMedicine (ACN) through world leading interdisciplinary researchers in diagnostics and therapeutic delivery will provide solutions to clinical challenges in medicine.

Vision of the ACN

The ACN will become the hub of all nanomedicine research in Australia and a gateway for international collaboration.

Aims of the ACN • Bringing together a multidisciplinary team of internationally recognised chemists, engineers and

other technologists with clinical and medical practitioners to more clearly understand the requirements to deliver improvements in health

• Showcasing and promoting nanomedicine through forums, publications, conferences and news outlets and seek feedback on new projects

• Working with Australian decision makers to deliver on national priorities for scientific excellence and industrial competitiveness

• Partnering with other academics and commercial ventures to contribute to advances in the field • Establishing the International Nanomedicine Conference in Sydney as a leading nanomedicine

conference in the Asia-Pacific region, and using this to leverage a strong network involving medical institutes and companies


Organisational Chart


ACN Affiliated Staff and Students

Centre Management

Co-directors - Scientia Professor Justin Gooding

Professor Maria Kavallaris School of Chemistry

Faculty of Science Children’s Cancer Institute Australia Faculty of Medicine

Deputy Director - Associate Professor Cyrille Boyer

School of Chemical Engineering Faculty of Engineering

Centre Manager - Dr Joshua Peterson

Members

Scientia Professor Katharina Gaus Professor Naresh Kumar Professor Richard Tilley* Conjoint Professor Ivan Greguric Associate Professor Pall Thordarson

Associate Professor Matthew Kearnes* Dr Joshua McCarroll Dr Phoebe Phillips* Dr Majid Ebrahimi Warkiani

From Left: Prof Naresh Kumar, Assoc Prof Pall Thordarson, Assoc Prof Matthew Kearnes, Dr Joshua McCarroll


Associate Members Professor Martina Stenzel Associate Professor Shelli McAlpine Dr May Lim Dr Renee Whan

ResearchFellows

Dr Elizabeth Hinde (VC) Dr Orazio Vittorio (VC) Dr S R C Vivekchand (VC) Dr Enrico Klotzsch Dr Alex Soeriyadi (NHMRC ECF) Dr Adam Martin*

Post-docs

Dr Abbas Barfidokht * Dr Bakul Gupta Dr Celine Heu* Dr Christopher Fife (grad 2015) Dr Declan Kuch* Dr Frieda Mansfeld* Dr Hongxu Lu Dr James Webb* Dr Jason (Jiangtao) Xu Dr Jet (Xiaoyu) Cheng* Dr Kyloon Chuah (grad 2015) Dr Miriam Brandl*

*Joined in 2015

From Left: Prof Martina Stenzel, Assoc Prof Shelli McAlpine, Dr May Lim, Dr Renee Whan


Postgraduate Students

PhD Students PhD Students (cont’d) Masters Students

Mr Nik Nik Mohd Adnan Ms Anouschka Akerman* Ms Sri Augustina Mr Ali Bagheri* Mr Lachlan Carter Mr Nat Corrigan* Ms Genevieve Duche Mr Abbas Farahani* Mr Christopher Fife (grad 2015) Mr Fei Han* Mr Md Musfizur Hassan* Mr Robert Healey* Ms Susan Ireland* Mr Cheng (Johnson) Jiang Mr Kenward Jung Ms Mohaddeseh Kahram* Ms Felicity Kao Mr Alexander Kross Ms Joanna Kwiatek Mr Alistair Laos* Mr Xun Lu Mr Yong (Jerry) Lu Mr Alex (Yuanqing) Ma* Mr Alex Mason* Ms Mahdie Mollazade Mr Saimon Moraes Silva*

Mr Walter Muskovic* Ms Ekaterina Nam* Ms Diep Nguyen Ms Khanh Nguyen Ms Susan Oliver* Ms Rahelleh Pardekhorram* Ms Amelia Parker* Mr Stephen Parker (grad 2015) Ms Maryam Parviz Ms Ranjana Piya Mr Mehdi Rafeie* Mr Andrew Robinson* Mr Siva Shanmugam Ms Parisa Sowti* Mr Manish Sriram* Mr Jason Tran Mr Vincent Tan Ms Safura Taufik Ms Joann Teo Ms Kristel Tjandra Mr Jonathan Wojciechowski Mr Chin Wong Mr Ming Han Eugene Yee Mr Jonathan Yeow Ms Leila Zarei Ms Manchen Zhao Ms Kelly Zong

Mr Xiankan He* Mr Xin Huang* Mr Li Ma* (grad 2015) Mr Srinath Ramakrishnan* Ms Lu Wang* Honours Students Ms Nadia Abdullah Mr Muhammad Amad Ms Wickramaarachige (Sachini) De Silva Mr Cameron Donnet Mr Eric Du Mr Nur Aqilah Haji Mohamed Sahali Ms Nurshafira Haji Sarbini Mr Warun Harhare Ms Hilary Huynh Ms Nur Latep Ms Tracy Li Ms Duyen Nguyen Ms Sharon Yu

*Joined in 2015


Steering Committee

The ACN Steering Committee is chaired by Professor Mark Hoffman (Presiding Dean) and is comprised of members from the associate Faculties of Science and Medicine. The 2015 Steering Committee meetings are noted below.

April 30 July 27 November 2 Professor Mark Hoffman (Chairman) Dean of Engineering, UNSW

● ● ●

Professor Merlin Crossley Dean of Science, UNSW

● ● ●

Professor Rodney Phillips Dean of Medicine, UNSW

● ●

Scientia Professor Ian Dawes School of Biotechnology and Biomolecular Sciences, UNSW

● ●

Professor Peter Gunning* School of Medical Sciences, UNSW

●

Professor Maria Kavallaris ACN Co-director Head of Program, Tumour Biology and Targeting Program, Children’s Cancer Institute Australia

● ● ●

Scientia Professor Justin Gooding ACN Co-director School of Chemistry, UNSW

● ● ●

Associate Professor Cyrille Boyer ACN Deputy Director School of Chemical Engineering, UNSW

● ● ●

Dr Joshua Peterson Centre Manager, Australian Centre for NanoMedicine

● ● ●

* Professor Peter Gunning stood down after Professor Rodney Phillips came on board


Highlights of Member Achievements ARC Laureate Fellowship

ACN Director Scientia Professor Justin Gooding was awarded $2.88 million to develop a new type of diagnostic device that can measure single molecules or single cells. This cutting-edge technology will not only be important for biological discovery, but could lead to the development of biosensors with applications in environmental monitoring, disease prediction, personalised medicine and drug discovery.

Professor Gooding won the Eureka Prize for Scientific Research in 2009 and the NSW Science and Engineering Award for Emerging Research in 2013. Professor Gooding also received an ARC Australian Professorial Fellowship in 2010.

Malcolm McIntosh Prize for Physical Scientist of the Year

ACN Centre Deputy Director Associate Professor Cyrille Boyer uses light to make new and complex polymers.

It’s the latest in a series of techniques that have enabled him to create materials which are being applied in areas as widespread as non-stick coatings, anti-fouling technology, precision drug delivery, medical diagnosis and imaging.

For his contributions to polymer science, nanotechnology and nanomedicine, Associate Professor Cyrille Boyer received the 2015 Malcolm McIntosh Prize for Physical Scientist of the Year.


The Knowledge Nation 100

ACN Centre Co-director Professor Maria Kavallaris and Deputy Director Associate Professor Cyrille Boyer were both recognised as one of ‘The Knowledge Nation 100’ - Australia’s top 100 “visionaries, intellects, founders and game changers” who will help shape the country’s future prosperity. The list, consisting of 10 recipients across 10 categories, was revealed at a lunch in Sydney attended by the Prime Minister, Malcolm Turnbull.

Westpac’s 100 Women of Influence in 2015

Awarded in the Innovation category, Professor Kavallaris is being acknowledged for her internationally recognised contributions as a senior research scientist in the field of cancer biology; for her advocacy work on behalf of medical research within the public, policy and political spheres; and for her inspiring leadership as Director of the Australian Centre for NanoMedicine at UNSW Australia.

Top 100 Most Influential Analytical Scientists in the World

Scientia Professor Justin Gooding has for the second year running been included in the Analytical Scientist's top 100 most influential analytical scientists in the world.

Professor Gooding is ACS Sensors Editor-in-Chief; Scientia Professor; ARC Australian Laureate Fellow; and founding Co-Director of

the Australian Centre for NanoMedicine.


Fellow of Australian Academy of Health and Medical Sciences

NHMRC-ARC Dementia Research Development Fellowship

Dr Phillips to Lead National Medical Research Body

ACN member Dr Phoebe Phillips was elected President of the Australian Society for Medical Research, the country’s peak professional medical research body.

As head of the Pancreatic Cancer Translational Research Group at Lowy Cancer Research Centre, Dr Phillips is developing new ways of accessing and destroying tumour cells in the pancreas.

‘Top 10 Innovators under 35’ in Asia-Pacific

ACN member Dr Majid Warkiani has been recognized by the prestigious MIT Technology Review for his pioneering research on

building miniaturised systems that separate the rare cells of the human body. Majid’s research has generated significant media interest in 2015 incl. ABC News and Daily Telegraph.

ACN Member Scientia Professor Katharina Gaus is elected as Fellow of the Australian Academy of Health and Medical Sciences. Professor Gaus leads the UNSW Centre for Single Molecule Science, is pioneering new ways of studying the rules that govern single molecules to better understand how our immune systems work on a cellular level.

ACN member Dr Adam Martin was awarded a four year NHMRC-ARC Dementia Research Development Fellowship valued at $594,644 for his project titled: Self-assembled hydrogels as a model for neurodegeneration.

http://powcs.med.unsw.edu.au/research/adult-cancer-program/pancreatic-cancer-translational

http://www.abc.net.au/news/2015-12-17/biochip-identifies-cancerous-cells/7039072

http://www.news.com.au/lifestyle/health/health-problems/government-denies-funding-for-cancer-treatment-device-that-detects-and-washes-cancer-cells-from-blood/news-story/8fe3aaa0ac11652cc33b1575d5aa2952


NHMRC Early Career Fellowship

ACN member Dr Alex Soeriyadi was awarded an NHMRC Early Career Fellowship. Alex received $309,436 for his 4 year project titled: Photonic Crystals for Probing Enzyme Activity: Single Cells vs Bulk Measurement.

Fresh Science Finalists

Michael Guilhaus Research Award

ACN member Dr Alex Donald won the inaugural Michael Guilhaus Research Award – a national prize for research in mass spectrometry that honours the memory of the late innovative UNSW instrument designer.

Dr Donald, who uses this analytical technique to study proteins, received the $10,000 award from the Australian and New

Zealand Society for Mass Spectrometry at the Society’s conference in Brisbane in July 2015. Alex was awarded the ARC Discovery Early Career Researcher Award (2013-2015) and Emerging Investigator, Analytical Methods (2015).

ACN members Dr Majid Warkiani and Dr. Elizabeth Hinde were named 2015 Fresh Science Finalists. Fresh Science is a national competition helping early-career researchers find, and then share, their stories of discovery.


ACN Member Profile

Professor Richard Tilley Dr Orazio Vittorio

Professor Richard Tilley is the Director of Electron Microscope Unit at UNSW. He joined the Australian Centre for NanoMedicine in 2015. His research is focused on the solution synthesis of nanoparticles and quantum dots for applications ranging from catalysis to biomedical imaging. He did his PhD in the Department of Chemistry, University of Cambridge, UK, after which he was a Postdoctoral Fellow for two years at the Toshiba basic R&D Center, Japan. A native of the UK, he graduated with a Masters of Chemistry from Oxford University, UK.

Professor Tilley’s research revolves around the synthesis, characterisation and applications of nanoparticles and nanomaterials. Nanoparticles hold a great fascination because they have different fundamental physical properties compared to bulk solids due to the very small size. Unique properties of nanoparticles include particle size dependent luminescence from semiconductor materials, superparamagnetism in magnetic materials and new and unusual crystal structures.

Dr Vittorio received his Master’s Degree in Biology with Honours from the University of Pisa in 2006 and in February 2011 he was awarded his PhD from the Department of Oncology, Transplants and New Technologies in Medicine at the University of Pisa, Italy.

He developed and tested novel nanovectors, based on carbon nanotubes functionalized with siRNA and chemotherapics for cancer treatment. In particular he studied the ideal combination of nanoparticles and drugs in order to increase their activity without additional side effects. Dr Vittorio’s track record reflects research excellence as an early career scientist with 31 peer-reviewed publications. He has authored 5 book chapters and is co-inventor on 4 patents. His career success includes receiving the 2008 Rotary/Lions club prize "For Innovative research" and in August 2013 the Kids' Cancer Project Award for "Outstanding Cancer Research".

Dr Vittorio joined the Australian Centre for Nanomedicine in 2013 when he was awarded a highly competitive Vice Chancellor's Postdoc Research Fellowship from UNSW to conduct his research at Children’s Cancer Institute Australia.


High Impact Papers Team ACN continued its great research and publication record in 2015. Below is a selection of our high impact papers that are considered highly influential in their field. S. Shanmugam, J. Xu, and C. Boyer, (2015) Utilizing the electron transfer mechanism of chlorophyll a under light for controlled radical polymerization, Chemical Science 6, 1341-1349.

• First article showing that chlorophyll can act as a photoredox catalyst to activate PET-RAFT.

• Ranked as ‘Hot Paper’ by Chemical Science. • Highlighted in Chemistry World (RSC magazine) and Chemistry in Australia.

S. Shanmugam, J. Xu, and C. Boyer, (2015) Exploiting Metalloporphyrins for Selective Living Radical Polymerization Tunable over Visible Wavelengths, Journal of the American Chemical Society 137, 9174-9185.

• Top 5 most read article in the Journal of the American Chemical Society for the months of August and September.

S. Shanmugam, C Boyer (2015) Stereo-, Temporal-and Chemical-Control through Photoactivation of Living Radical Polymerization: Synthesis of Block and Gradient Copolymers, Journal of the American Chemical Society, 137 (31), 9988–9999.

• Highlighted in Chemistry in Australia, November 2015.

J. Xu and C. Boyer (2015) Visible Light Photocatalytic Thiol-ene Reaction: An Elegant Approach for Ultrafast Polymer Post-Functionalization and Step-Growth Polymerization, Macromolecules, 48 (3) 520-529.

• First article showing the use of photoredox chemistry for the post-modification of function polymers via thiol-ene.

• Ranked amongst the ‘Most Downloaded Papers’ in February/March 2015. • Ranked as one of the “Most Downloaded Papers” for Year 2015.

M.H. Choudhury, S. Ciampi, Y. Yang, R. Tavallaie, Y. Zhu, L. Zarei, V.R. Gonçales, J.J. Gooding, Connecting electrodes with light: one wire, many electrodes, Chem. Sci. 6 6769-6776 (2015).

• Highlighted in Chemistry World November 2015, page 32 “Electrodes Connected with Light”.

• Australian Newspaper article, December 1st, "Electronics, but not as we know it" by John Ross.

• Method of making high density electrochemical sensing arrays for rapid diagnostics.


Y.H. Zheng, A. Soeriyadi, L. Rosa, S.H. Ng, U. Bach, J.J. Gooding, Reversible gating of smart plasmonic molecular traps using thermoresponsive polymers for single-molecule detection, Nature Comm. 6 Art. No. 8797 (2015).

• Highlighted in Chemistry in Australia, 2015. • Smart surface for single molecule sensing.

X. Cheng, E. Hinde, D.M. Owen, S.B. Lowe, P.J. Reece, K. Gaus, J.J. Gooding, Enhancing Quantum Dots for Bioimaging using Advanced Surface Chemistry and Advanced Optical Microscopy: Application to Silicon Quantum Dots (SiQDs), Adv. Mater. 27 6144-6150 (2015).

• Highlighted in Chemistry in Australia, 2015. • Solves a long standing problem with using safe quantum dots for bioimaging and in

medicine.

C.K. Wong, A.J. Laos, A.H. Soeriyadi, J. Wiedenmann, P.M.G. Curmi, J.J. Gooding, C.P. Marquis, M.H. Stenzel, P. Thordarson, Polymersomes Prepared from Thermoresponsive Fluorescent Protein–Polymer Bioconjugates: Capture of and Report on Drug and Protein Payloads, Angew. Chem. Int. Ed. 54 5317-5322 (2015).

• Highlighted in Chemistry in Australia, 2015. • Sophisticated nanoparticle drug delivery vehicle based on novel polymer-protein

conjugates.

J. A. McCarroll, P. P. Gan, R. B. Erlich, M. Liu, T. Dwarte, S. S. Sagnella, M. C. Akerfeldt, L. Yang, A. L. Parker, M. H. Chang, M. S. Shum, F. L. Byrne, and M. Kavallaris. TUBB3/βIII-tubulin acts through the PTEN/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer, Cancer Research 2015, 75;415-425.

• ISI highly cited article. • Highlighted in the “Breaking Advances: Highlights from the recent cancer

literature” in the journal Cancer Research.

Above: Front cover of the January 2015 issue of Cancer Research journal.


Centre Activity Highlights 6th International NanoMedicine Conference ACN has established the International NanoMedicine Conference series, which is now in its 6th year in 2015. This event is regarded as the most significant nanomedicine meeting in the Southern Hemisphere, taking place annually at our local beach, Coogee Beach Sydney, early July. The 6th International NanoMedicine Conference was held from 6-8 July 2015 at Crown Plaza, Coogee. 240 delegates including 30 International delegates from 19 countries and 80 delegates from interstate attended the conference. 100 talks and 60 posters were presented at the Conference. The conference has a unique Clinical Challenges Session which is focused on generating ideas as opposed to the standard presentation of results. It gives medical doctors and clinicians a forum to present the challenges they face in treating diseases directly to the research community and ensure that research efforts are focused on goals that will actually improve patient care. The session aims to lead to research collaborations between doctors and scientists and have more targeted research with the end user (the clinicians) being part of the development effort.

UNSW Senior DVC Professor Les Field closed the conference

UNSW Dean of Medicine Professor Rodney Phillips opened the Conference


Clinician Outreach The ACN has launched a new section of the ACN website in 2015 as a “Clinician’s Portal” to help explain our technologies in a way that’s more accessible/useful for clinical practitioners.

This is inspired by the great success of the ‘Clinical Challenges’ session of the 6th International NanoMedicine Conference. As a result of interaction at the conference, all four of the speakers have indicated that they will maintain a relationship with the ACN and be available to join us for seminars and round table discussions to help develop and direct research efforts.

Clinician Profiles

Associate Professor Glen Reid

Associate Professor Glen Reid was appointed ADRI’s Senior Research Scientist in April 2009, and he established the Institute’s cell and molecular biology labs. He is also conjoint Associate Professor at the University of Sydney Medical School.

His research focuses on the identification of new markers and molecular targets for malignant mesothelioma, with a particular focus on microRNAs. This work has laid the foundations for the current clinical trial of microRNA replacement as a therapeutic approach in malignant pleural mesothelioma and non-small cell lung cancer patients.

He currently holds grants from the Cancer Institute NSW and Cancer Council NSW.

Dr Steven Kao

Dr Steven Kao is a medical oncologist at the Chris O’Brien Lifehouse, Camperdown. He completed his PhD at the ADRI and focused his research on predictive and prognostic factors in malignant mesothelioma. Steven has a wide clinical, translational and psycho-social research interest in thoracic cancers including malignant mesothelioma and asbestos-related lung cancers. He was awarded the Premier’s Award for Outstanding Cancer Research Scholar from The Cancer Institute NSW in 2012.


Strategic Initiative – Seed Funding Program The ACN launched the Seeding Funding program in 2015 to provide seed funding to ACN members to pursue research that can lead to future grant applications. The goal is to support researchers in generating initial data/results that can be used to help them apply for grants, preferably in the following year.

The following five projects were funded through the ACN Seed Funding Program in 2015 with preference given to cross faculty and cross disciplinary research proposals:

• Develop polymer production line using NIR light activated polymerisation to produce polymeric NPs for drug delivery

• Develop polymer mimics of extracellular matrix for 3D tumour modelling using visible light activated cross linking

• High-throughput assays to systematically study stability of gel encapsulated proteins for localised biomolecule delivery

• Develop microfluidic device for rapid patterning of cells with interlaced configuration for electrophysiological characterization of neuron-Schwann cell activity*

• Silk fibroin derived material for application in chronic wound healing for diabetic patients*

*Identified specific grant applications in 2016 that would be pursued as a result of the project

Left: Dr Robert Utama Dr. Robert Utama completed his BE (1st Class Honours, Co-op scholar) in Industrial Chemistry in 2010 and PhD in Engineering in 2014 from UNSW. He is a now research associate within the School of Chemistry and a member of the ACN. Dr Utama was a recipient of the 2015 Seed Funding program. He and colleagues have successfully synthesised and characterised the Polymers as proposed. The team took the project further and designed a highly modular polymer suitable for controlling the mechanical stiffness of the hydrogel as well as the compositions of the biomolecules. A manuscript related to this project is currently being written.


Postgraduate Student Projects

In 2015, there were 71 postgraduate students in the ACN – 24 in the Faculty of Engineering, 13 in the Faculty of Medicine and 34 in Science. Of the 71 students, 53 were enrolled as PhD students, 5 Masters and 13 Honours students. The project titles for all post graduate students in the ACN are listed below.

NAME DEGREE FACULTY PROJECT TITLE

Mr Nik Nik Mohd Adnan

PhD Engineering Hybrid nanocarrier for controlled delivery of drugs

Ms Anouschka Akerman

PhD Medicine The use of nanomedicines to treat Pancreatic Cancer

Ms Sri Augustina PhD Engineering Morphology control of polymeric nanoparticles using membrane emulsification

Mr Ali Bagheri PhD Engineering Light Triggered Release of Antibiotics from Upconversion Nanoparticles Functionalised with Hydrogel

Mr Lachlan Carter

PhD Science Super-resolution light microscopy as a single-molecule biosensing tool

Mr Nat Corrigan PhD Engineering Photoinduced ambient temperature polymerisations

Ms Genevieve Duche

PhD Science The release of biomacromolecules from self-assembled gels

Mr Abbas Farahani

PhD Science The design of self-assembled gels for tissue engineering

Mr Christopher Fife

PhD Medicine The Delivery of siRNA using Nanoparticles in Pancreatic Cancer

Mr Fei Han PhD Science Responsive nanoparticle dimers Mr Md Musfizur Hassan

PhD Science Self-assembly and drug delivery

Mr Robert Healey PhD Science The supramolecular chemistry of G-protein coupled receptors

Ms Susan Ireland PhD Science Allosteric interactions in G-protein coupled receptors

Mr Cheng (Johnson) Jiang

PhD Science Biosensors fabricated using low impedance antifouling surfaces

Mr Kenward Jung PhD Engineering Photoinitiated radical polymerization in emulsion

Ms Mohaddeseh Kahram

PhD Science Electrically switchable polymers

Ms Felicity Kao PhD Medicine Investigating the therapeutic potential of microRNAs in glioblastoma



Mr Alexander Kross

PhD Medicine Olfactory signalling elements and membrane organisation of olfactory receptor neurons

Ms Joanna Kwiatek

PhD Medicine Imaging membrane domains in live cells

Mr Alistair Laos PhD Science Controlling protein folding Mr Xun Lu PhD Science Superresolution light microscopy for

characterising biointerfaces Mr Yong (Jerry) Lu

PhD Science The microfabrication of surfaces for cell biology

Mr Alex (Yuanqing) Ma

PhD Medicine Novel fluorescence sensor for T cell activation

Mr Alex Mason PhD Science Tools for Synthetic Cell Research Ms Mahdie Mollazade

PhD Medicine Functionalised nano-structured surfaces for cell adhesion.

Mr Saimon Moraes Silva

PhD Science MicroRNA detection with magnetic nanoparticles

Mr Walter Muskovic

PhD Medicine The role of βIII-Tubulin in Non-small Cell Lung Cancer

Ms Ekaterina Nam

PhD Science Surface-bound light-activated redox enzyme cascades

Ms Diep Nguyen PhD Engineering Macromolecular scaffolds for carbon monoxide delivery

Ms Khanh Nguyen

PhD Engineering Polymeric nanoparticles for anti-biofilm application in the treatment of infectious diseases

Ms Susan Oliver PhD Engineering Using transition metal nanoparticles for therapeutic applications

Ms Rahelleh Pardekhorram

PhD Science The detection of microbial species on foods using functionalised gold nanorods

Ms Amelia Parker

PhD Medicine Investigation of the role of βIII-Tubulin in Glioblastoma Multiforme Tumourigenesis & Response To Therapy

Mr Stephen Parker

PhD Science Capture-release surfaces for circulating tumour cells

Ms Maryam Parviz

PhD Science Combining fluorescence microscopy with electrochemistry for cell biology

Ms Ranjana Piya PhD Science Single-cell porous silicon biosensors Mr Mehdi Rafeie PhD Engineering Advanced microfluidics systems for particle/cell

sorting and cancer research Mr Andrew Robinson

PhD Science Therapeutic Peptides and Peptide Hydrogelators for Medical Application



Mr Siva Shanmugam

PhD Engineering Development of spatial and temporal control of light mediated RAFT polymerization

Ms Parisa Sowti PhD Science Sunburn sensors based on titanium dioxide-polymer composite films

Mr Manish Sriram

PhD Science Single particle sensors based on dark field microscopy

Mr Vincent Tan PhD Science Artificial ECMs for 3D printing of cells Ms Safura Taufik PhD Science A biosensor for haemoglobin Ms Joann Teo PhD Medicine Discovery of a small molecule TUBB3/betaIII-

tubulin modulator in non-small cell lung cancer Ms Kristel Tjandra

PhD Science Cancer-targeting peptide-RNA conjugates

Mr Jason Tran PhD Medicine Nanoscale organisation of adhesion and actin cytoskeleton

Mr Jonathan Wojciechowski

PhD Science Structure-property relations in self-assembled gels

Mr Chin Wong PhD Science Self-assembled FRET-able multifunctional nanocarriers

Mr Ming Han Eugene Yee

PhD Science Synthesis of novel flavonoid hybrids and development of their delivery system

Mr Jonathan Yeow

PhD Engineering Biomedical Applications of Nanoparticles Synthesised Using Polymerization-Induced Self-Assembly (PISA)

Ms Leila Zarei PhD Science Electrochemical DNA arrays using light activated electrochemistry

Ms Manchen Zhao

PhD Science Single molecule pulldown assays

Ms Kelly Zong PhD Science Single particle tracking for drug delivery Mr Xiankan He Masters Engineering Photoinduced Living Radicals Polymerization to

Create Well Defined Polymers Mr Xin Huang Masters Engineering Hybrid Nanoparticles for Co-delivery of Silver

ions and Nitric oxide Mr Li Ma Masters Engineering Photoinduced Living Radicals Polymerization to

Create Well Defined Polymers Mr Srinath Ramakrishnan

Masters Engineering Polymer post modification by photo redox catalysis

Ms Lu Wang Masters Engineering Control of the nanoparticle shape



Ms Nadia Abdullah

Honours Engineering Gold Nanoparticle for Drug Delivery

Mr Muhammad Amad

Honours Engineering Polymer Coated Gold Nanoparticles for Cancer Treatment

Ms Wickramaarachige (Sachini) De Silva

Honours Engineering Encapsulation of photosensitisers in polymeric nanoparticles via Photoinduced Electron Transfer- Reversible Addition Fragmentation Chain Transfer (PET-RAFT) Polymerisation

Mr Cameron Donnet

Honours Medicine The development of RNA interference nanomedicines for the treatment of childhood neuroblastoma

Mr Eric Du Honours Science Controlling stem cell differentiation with self-assembled gels

Mr Nur Aqilah Haji Mohamed Sahali

Honours Engineering Visible light induced living radical polymerization with novel donor-acceptor photocatalyst

Ms Nurshafira Haji Sarbini

Honours Engineering Living Radical Polymerization Using electron donor (TEA) and electron carrier (TEA)

Mr Warun Harhare

Honours Engineering Study of photopolymerization using visible light spectrum

Ms Hilary Huynh Honours Science Self-assembled gels in cell culture 3D tumour modelling

Ms Nur Latep Honours Engineering Polymeric Nanoparticles as Anti-Biofilm Agent (Silver Nanoparticle)

Ms Tracy Li Honours Medicine Targeting tumourigenicity and metastases in pancreatic cancer using a novel nanoparticles to deliver RNA Interference Therapeutics

Ms Duyen Nguyen Honours Science Hydrogels as Extracellular Matrix Mimics Ms Sharon Yu Honours Engineering Dual-Action Antimicrobial Surfaces and

Polymers

Left: Susan Oliver

Susan commenced her PhD in March 2015 working with Associate Professor Cyrille Boyer in School of Chemical Engineering. Susan is also working in collaboration with Dr Orazio Vittorio and Professor Maria Kavallaris from Children's Cancer Institute Australia who have tested some of the new polymer conjugates she has developed in vitro on neuroblastoma cells as well as normal cells.


PhD Student Profiles Dr. Stephen Parker Ms Parisa Sowti Khiabani

Stephen Parker completed a Bachelor of Nanotechnology from UNSW in 2010 before undertaking a Ph.D. in the Biosensors and Biointerfaces research group and the Australian Centre for Nanomedicine within the School of Chemistry at UNSW. His project focused on developing a technique to isolate individual diseased cells without compromising their integrity. Throughout his doctoral thesis, he was the recipient of the AINSE postgraduate research award, as well as being a Paddon-Row and Royal Society of NSW scholar. Stephen completed his PhD in 2015. He is now a postdoctoral research associate within the Biosensors and Biointerfaces research group, the Australian Centre for Nanomedicine and the Centre of Excellence in Convergent Bio Nano Science and Technology to continue to develop the single-cell isolation device to a commercially-available product.

Ms Parisa Sowti Khiabani is a PhD student in Scientia Professor Justin Gooding’s group. Parisa is part of Justin’s research team that developed a "smart" paper-based sensor. The sensor changes colour in sunlight which could provide an affordable tool to help prevent sunburn and deadly skin cancers. “Australia has one of the highest incidences of skin cancer in the world, and too much exposure to ultraviolet light is the primary cause. We wanted to develop a technology that could address this serious health problem, and we wanted it to be safe, affordable and easy to use,” says Parisa. The technology has been patented by UNSW Innovations and is ready to be commercialised immediately.

http://newsroom.unsw.edu.au/news/health/[email protected]


Collaborating Organisations

Collaborating Organisation Country

ANSTO Australia Benitec Australia Children's Cancer Institute Australia Clockwerk Pty Ltd Australia CSIRO Australia EnGeneic Australia Inventia Life Sciences Australia Macquarie University Australia Mark Wainwright Analytical Centre, UNSW Australia Melbourne University Australia Monash University Australia Neptune Bio-Innovations Pty Ltd Australia Panorama Synergy Australia Single Molecule Laboratory, UNSW Australia Sydney Children’s Hospital Australia University of South Australia Australia University of Wollongong, ARC Centre of Excellence in Electromaterials Australia University of Queensland Australia Victor Chang Cardiac Research Institute Australia University of Ghent Belgium Memorial University of Newfoundland Canada Qingdao University China Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Key Laboratory of Sustainable Development of Marine Fisheries

China

Center for Radiation Research in Oncology Germany Leibniz Institute for Solid State and Materials Research of Dresden Germany Ruhr-Universität Bochum Germany University of Parma Italy


Collaborating Organisation Country

MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington

New Zealand

Advanced Soft Matter Group – Delft University of Technology The Institute for Molecular Materials, Radboud University Nijmegen The Beatson Institute, Glasgow Scotland UK

Coral Reef Laboratory / Institute for Life Science (IfLS), University of Southampton

UK

Imperial College London UK Making Science Public Initiative, University of Nottingham UK Science, Society and Sustainability Group, University of East Anglia UK Science, Technology and Innovation Studies group, Edinburgh University UK University of Liverpool UK AgaMatrix, Inc. USA Center for Nanotechnology in Society, Arizona State University USA Center for Nanotechnology in Society, University of California, Santa Barbara USA Princeton University USA University of California Davis, USA USA University of Texas, Austin USA

Left: Dr Declan Kuch

Dr Declan Kuch is a research fellow in the Faculty of Arts and Social Sciences at UNSW and joined the ACN in 2015. Declan is a great addition to the multidisciplinary team of the ACN. His research has spanned issues in energy, climate, law and the life sciences. Declan served on the planning committee of the 7th International Nanomedicine Conference and was a Theme Leader for Social Aspects theme at the Conference.



ACN Member Grants

Total funding for ACN member research has reached a record level of $6M in 2015 with the expectation of further growth in 2016. Below is a list of ACN funding highlights in 2015. 2015 New Grants Highlights

Year Funding $ Grant

2015-2018 410,000 ARC Linkage Grant, LP150101014, A gold-coated magnetic nanoparticle biosensor for detecting microRNA, Gooding, Williams (AgaMatrix), Kavallaris

2015-2018 226,218 AgaMatrix Inc., A gold-coated magnetic nanoparticle biosensor for detecting microRNA, Gooding, Williams (AgaMatrix), Kavallaris

2015-2020 2,875,097 ARC Laureate Fellowship FL150100060, The first generation of single entity measurement tools for analysis, Gooding

2015-2016 177,310 Research Connections Grant RC46696, Development of a MEMS based Hydrogen Detector using LumiMEMS, Gooding, Chaffey (Panorama Synergy)

2015-2017 419,700 ARC Discovery Grant, DP150103065, Light Activated Electrochemistry: Microelectrode Arrays with just one wire, Gooding, Ciampi

2015 560,000 ARC LIEF, LE150100163, Single molecule imaging laboratory, K. Gaus, J.J. Gooding, T. Boecking, L. Lee, J.C. Whisstock, J. Rossjohn, P.J. Hertzog, W.R. Heath, D.I. Godfrey, D.M. Hatters, H.M. Quiney, B. Abbey, F.C. Braet, NJ. King, G.E. Grau, A.M. van Oijen, E. Goldys, J. Mak, F.A. Meunier, A.S. Yap, N.S. Eyre, S.M. Russell

2015 240,000 ARC LIEF, LE150100075, Fabrication Facility for Oxygen-Sensitive Electronic Materials, D.R. McCamey, T. Schmidt, G. Lakhwani, J.J. Gooding, D.M. D'Alessandro, J.N. Hart.


Year Funding $ Grant

2015 25,000 Organisation for the Prevention of Chemical Weapons (OPCW), Surface selective ionization mass spectrometry (SelectION-MS) for the detection of chemical warfare agent simulants and their degradation products in complex mixtures, M. Dumlao, J.J. Gooding, W.A. Donald

2015 100,000 Oncology Children's Foundation, M Kavallaris

2015 500,000 Cancer Institute NSW Research Equipment Grant, Using fluorescence to determine molecular pathogenesis, progression and treatment of cancer. A Zeiss 880 confocal multiphoton system with Airy detector and fluorescence lifetime capability, P. Gunning, R. Whan, E. Hinde, P. Hogg, P. Timpson, J. Rasko, J.G. Lyons, M. Kavallaris

2015 500,000 Cancer Institute NSW Research Equipment Grant, High resolution fourier transform mass spectrometry platform for the discovery of novel cancer biomarkers and drug targets using label-free and isobaric-tagged approaches for quantitative proteomics, X. Dong Zhang, M. Dun, J. Martin, H. Hondermarck, J. Aitken, N. Verrills, P. Tanwar, R. Scott, M. Kavallaris, D. Saunders

Left: Vice Chancellor Professor Ian Jacobs & Mr Sivaprakash Shanmugam at Nano Lab. Siva completed his B.S. in Biochemistry from Case Western Reserve University in 2013. He is currently a PhD student in Chemical Engineering under the direction of Assoc Prof Cyrille Boyer. His research focuses on the development of spatial, temporal, and sequence control of light-mediated RAFT polymerization. Siva is also a recipient of 2015 Seed Funding program. The outcome of the project was published in Angewandte Chemie as a VIP (very important paper).

Link: http://onlinelibrary.wiley.com/doi/10


Awards and Honours

Name Award / Honour Date

Professor Maria Kavallaris

Science Chair, Australian Institute for Policy and Science – board meeting

11 April


Appointed to the Research Committee of the National Health and Medical Research Council (NHMRC)

25 August


Named one of The Australian Financial Review and Westpac’s 100 Women of Influence in 2015

15 October


Named in the “Knowledge Nation 100” (Australia’s top 100 visionaries, intellects, founders and game changers who help shape the country’s future prosperity)

10 December


ASMR Research Fund Executive Committee 2015


Member of the Migration and Invasion Section of the Tumor Biology Subcommittee of the 2016 Program Committee, American Association Cancer Research

2015


Chair, National Training and Mentoring Committee, ARC Centre of Excellence in Bio-Nano Science

2015


NHMRC Research Fellowship Peer Review Panel 2015

Scientia Professor Justin Gooding

Awarded Australian Research Council Australian Laureate Fellowship of over $2.8M

24 June


Appointed Inaugural Editor-in-Chief of the American Chemical Society journal, ACS Sensors

22 July




Listed in The Analytical Scientist magazine as one of the top 100 most influential analytical scientists worldwide for 2015

10 December


Vice President International Society of Electrochemistry

2015


Member of the editorial board (Handling) of the American Scientific Publishers Journal of Chemical and Biological Interfaces from 2013-.

2015


Member of the editorial board of the Elsevier journal Electrochemistry Communications from 2003-.

2015


Member of the editorial board of the Humana Press journal Nanobiotechnology from 2005-

2015


Member of the editorial board of the Wiley journal, Electroanalysis 2006-.

2015


Member of the editorial board of the Elsevier journal Sensors and Actuators B 2008-.

2015


Member of the editorial board of the Royal Society of Chemistry journal, the Analyst 2009-2015.

2015


Member of the advisory editorial board of the Royal Society of Chemistry journal, Chemical Sciences 2010-.

2015


Member of the editorial board of the MDPI journal Biosensors 2010-.

2015


Member of the editorial board of the Wiley-VCH journal, ChemElectroChem 2013-.

2015


Member of the editorial advisory board of the ACS journal, Bioconjugate Chemistry 2014-.

2015




Member of the editorial board of the Wiley-VCH journal, Chemistry – A European Journal 2014-.

2015


Member of the editorial board of the MDPI journal, Nanomaterials 2015-.

2015

Assoc Prof Cyrille Boyer

Appointed Associate Editor of RSC Advances 1 September


Awarded the 2015 Malcolm McIntosh Prize for Physical Scientist of the Year

21 October


Named in the “Knowledge Nation 100” (Australia’s top 100 visionaries, intellects, founders and game changers who help shape the country’s future prosperity)

10 December


Visiting Professor at Faculty of Pharmacy, University of Nancy, (1 month), funded by University of Nancy, France

2015


Named as a High-end Foreign Expert by Chinese Government for 2015 – 2017

2015


Nominated in the Australian Research Council as member of College

2015

Assoc Prof Pall Thordarson

Associate and Handling Editor, Australian Journal of Chemistry

2015


Editorial Board member, “Gels” (publisher, MDPI). 2015


Editorial Board member “Frontiers in Materials Science – Colloidal Materials and Interfaces”

2015


Australian Research Council (ARC) College of Expert member

2015



Dr Alex Donald Australian and New Zealand Society for Mass Spectrometry Michael Guilhaus Research Award

2015

Dr Alex Donald Emerging Investigator, Analytical Methods 2015

Dr Alex Donald ARC Discovery Early Career Researcher Award 2015

Dr Adam Martin Awarded a four year NHMRC-ARC Dementia Research Development Fellowship valued at $594,644

19 October

Dr Alexander Soeriyadi

Recipient of a NHMRC Early Career Fellowship to examine Photonic Crystals for Probing Enzyme Activity: Single Cells vs Bulk Measurements

2015

Dr Phoebe Phillips President for the Australian Society of Medical Research (2015-2016)

23 February

Ms Amelia Parker Selected to attend 65th Lindau Nobel Laureate Meeting held 28 June – 3 July

13 March

Mr Alistair Laos Presented at the 2015 Photosynthesis Gordon Research Seminar

1 July

Mr Alistair Laos Granted admission to Princeton University (NJ, USA) as a Visiting Student

1 July

Dr Roya Tavallaie Won 1st place in the Poster Prize Competition at the 6th International Nanomedicine Conference

8 July

Mr Kitiphume Thammasiraphop

Honourable Mention for Best Oral Presentation by a Research Student at the 6th International Nanomedicine Conference

8 July

Dr Elizabeth Hinde

Named Fresh Science Finalist 26 August



Dr Majid Warkiani Named Fresh Science Finalist 26 August

Dr Majid Warkiani Named in the 'top 10 innovators under 35' in Asia-Pacific

15 November

Dr Majid Warkiani ABC News interview: Biochip identifies cancerous cells, 'washes' blood clean of cancer in dialysis-style treatment

17 December

Dr. Xiaoyu Cheng “2015 National Award for Outstanding Self-financed Chinese Students Study Abroad” by the Chinese Scholarship Council. One of only 500 awards worldwide.

2015

Above: Associate Professor Grainne Moran (Mark Wainwright Analytical Centre) and Professor Mary O’Kane (NSW Chief Scientist & Engineer) presenting prizes at the 6th International NanoMedicine Conference


Conference Papers and Presentations

The ACN team puts great value on the knowledge shared and gained at conferences both local and international. Below is a selection of keynote, invited and poster presentations.


Keynote speaker (Financially supported) Making Silicon a Responsive Material for Biosensing and Biolabelling Applications AMN-7: Advanced Materials and Nanotechnology, Nelson, New Zealand, 8-12 February, 2015 Keynote speaker (Financially supported) Molecularly Engineered Surfaces For Influencing Cells And Measuring Their Response To Stimuli, 5th International Symposium of Surface and Interface of Biomaterials, Sydney, Australia, 7-10 April, 2015 Invited speaker (Financially supported) Light Activated Electrochemistry: A strategy for performing voltammetry on a monolithic surface where you want, when you want with micron scale spatial resolution, Pittcon 2015, New Orleans, USA, 8-12 March, 2015


Scientia Professor Justin Gooding (cont’d)

Plenary speaker Making Silicon a Responsive Material for Biosensing and Biolabelling Applications, Institute of Advanced Studies Conference on Biomaterials for Medical Applications, Hong Kong, China, 20-23 April, 2015

Plenary speaker Light Activated Electrochemistry: A strategy for performing voltammetry on a monolithic surface where you want, when you want with micron scale spatial resolution, 15th International Symposium on Electroanalytical Chemistry (15th ISEAC), Changchun, China, 13-16 August 2015

Keynote speaker (Financially supported) Nanotechnology and diagnostics: The shift from detection of small molecules to the activity of whole cellsRoche Annual Symposium on Rheumatology, Sydney, Australia, 21-22 August 2015

Keynote speaker Light Activated Electrochemistry: A strategy for performing voltammetry on a monolithic surface where you want, when you want with micron scale spatial resolution, Meeting of the International Society of Electrochemistry, Taipei, Taiwan, 4-9 October 2015


Keynote speaker Lung Cancer: Microtubules and Therapeutic Targeting, Australasian Gene and Cell Therapy Conference, Melbourne, Australia, 29 April - 1 May, 2015

Invited speaker Nanotechnology meets therapeutics for refractory cancer, ComBio 2015, Melbourne, Australia, 27 September - 1 October, 2015


Associate Professor Cyrille Boyer Invited speaker Application of Light in Nanomedicine, 13th International Conference of Polymers for Advanced Technologies, Hangzhou, China, 25-28 June, 2015

Dr Majid Warkiani

Keynote speaker Microfluidic Platforms for Cancer Diagnosis, 1st International Nastaran Cancer Symposium, Mashhad, Iran42278 Invited speaker The Emerging Role of Inertial Microfluidics in Large-Volume Cell Sorting, Advances in Microfluidics and Nanofluidics Conference (AMN 2015), Beijing, China, 19-21 August, 2015 Invited speaker The emerging role of inertial microfluidics for ultra-high throughput, label-free cell sorting, 5th International Symposium of Surface and Interface of Biomaterials, Sydney, Australia, 7 - 10 April, 2015

Dr Joshua McCarroll

Invited speaker The role of microtubules in regulating tumour growth and chemotherapy drug sensitivity15th Australian Cell Cycle MeetingSydney, Australia, 30 March - 1 April, 2015 Invited speaker Tackling Pancreatic Cancer using a Novel Nanotechnology-siRNA Therapeutic, The Lowy Cancer Symposium, Sydney, Australia, 4 - 6 May, 2015

Dr Orazio Vittorio

Poster Dextran-Catechin conjugate: Targeting copper metabolism in neuroblastoma, EACR-AACR-SIC Special Conference, Florence, Italy, 20-23 June, 2015


Publications

Book Chapters 1. Ho KKK; Kutty SK; Chan D; Chen R; Willcox MDP; Kumar N, 2015, 'Development of

fimbrolides, halogenated furanones and their derivatives as antimicrobial agents', in Antibacterial Surfaces, pp. 149 - 170, http://dx.doi.org/10.1007/978-3-319-18594-1_8

2. Kearnes M, 2015, 'Miraculous engineering and the climate emergency: Climate modification as divine economy', in Technofutures, Nature and the Sacred: Transdisciplinary Perspectives, pp. 219 – 237

3. Magenau, A., and Gaus, K. (2015) 3D super-resolution imaging by localization microscopy, In Methods in Molecular Biology, pp 123-136.

4. Ma Y, Hinde E, Gaus K (2015) Nanodomains in biological membranes. Chapter in Membrane Nanodomains in the Essays in Biochemistry series, edited by I. Parmryd, Portland Press Ltd. London, UK. 57, (93–107) (Printed in Great Britain)

Websites P. Thordarson, www.supramolecular.org and www.opendatafit.org Two additional websites launched in April 2015 and sponsored by the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. Both these sites and others that are to follow have the over-arching aim of providing researcher in Bio-Nano Science with open access to various tools and information that enhance their research capabilities.

Left: Front cover of Polymer Chemistry in February 2016.

S. Oliver, O. Vittorio, G. Cirillo, C. Boyer (2016) Enhancing the therapeutic effects of polyphenols with macromolecules, Polymer Chemistry, 7, 1529-1544. (Front Cover)

http://dx.doi.org/10.1007/978-3-319-18594-1_8

http://www.supramolecular.org/

http://www.opendatafit.org/


Papers in Refereed Scientific and Technical Journals

Target Actual 2013

Actual 2014

Actual 2015

Number of Publications 29 74 83 1. Alvarez-Guaita A; Vilà De Muga S; Owen DM; Williamson D; Magenau A; García-Melero A;

Reverter M; Hoque M; Cairns R; Cornely R; Tebar F; Grewal T; Gaus K; Ayala-Sanmartín J; Enrich C; Rentero C, 2015, 'Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains', British Journal of Pharmacology, vol. 172, no. 7, pp. 1677 -1690, http://dx.doi.org/10.1111/bph.13022

2. Al-Zyoud WA; Hynson RMG; Ganuelas LA; Coster ACF; Duff AP; Baker MAB; Stewart AG; Giannoulatou E; Ho JWK; Gaus K; Liu D; Lee LK; Böcking T, 2015, 'Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site',Nucleic Acids Research, vol. 44, no. 3, pp. 1411 - 1420, http://dx.doi.org/10.1093/nar/gkv1466

3. Asadnia M; Kottapalli AGP; Miao J; Warkiani ME; Triantafyllou MS, 2015, 'Artificial fish skin of self-powered micro-electromechanical systems hair cells for sensing hydrodynamic flow phenomena',Journal of the Royal Society Interface, vol. 12, no. 111, http://dx.doi.org/10.1098/rsif.2015.0322

4. Balmer AS; Calvert J; Marris C; Molyneux-Hodgson S; Frow E; Kearnes M; Bulpin K; Schyfter P; MacKenzie A; Martin P, 2015, 'Taking roles in interdisciplinary collaborations: Reflections on working in post-ELSI spaces in the UK synthetic biology community', Science and Technology Studies, vol. 28, no. 3, pp. 3 - 25

5. Benda A; Ma Y; Gaus K, 2015, 'Self-calibrated line-scan STED-FCS to quantify lipid dynamics in model and cell membranes', Biophysical Journal, vol. 108, no. 3, pp. 596 - 609, http://dx.doi.org/10.1016/j.bpj.2014.12.007

6. Boyer C; Hoogenboom R, 2015, 'Multi-responsive polymers', European Polymer Journal, vol. 69, pp. 438 - 440, http://dx.doi.org/10.1016/j.eurpolymj.2015.06.032

7. Carter L; Chuah K; Tavallaie R; Barfidokht A; Parker SG; Gooding JJ, 2015, 'Switching "on and off" faradaic electrochemistry at an otherwise passivated electrode using gold-coated magnetic nanoparticles', Electrochemistry Communications, vol. 61, pp. 93 - 96, http://dx.doi.org/10.1016/j.elecom.2015.10.012

8. Castro Nava A, Cojoc M, Peitzsch C, Cirillo G, Kurth I, Fuessel S, Erdmann K, Kunhardt D, Vittorio O, Hampel S, Dubrovska A, 2015, ‘Development of novel radiochemotherapy approaches targeting prostate tumor progenitor cells using nanohybrids’, International Journal of Cancer 2015 DOI: 10.1002/ijc.29614.

9. Chen Y, Cass SL, Kutty SK, Yee EM, Chan DS, Gardner CR, Vittorio O, Pasquier E, Black DS, Kumar N, 2015, ‘Synthesis, biological evaluation and structure–activity relationship studies of isoflavene based Mannich bases with potent anti-cancer activity’, Bioorganic & Medicinal Chemistry Letters, 2015:25:22: 5377-5383.

http://dx.doi.org/10.1111/bph.13022

http://dx.doi.org/10.1093/nar/gkv1466

http://dx.doi.org/10.1098/rsif.2015.0322

http://dx.doi.org/10.1016/j.bpj.2014.12.007

http://dx.doi.org/10.1016/j.eurpolymj.2015.06.032

http://www.ncbi.nlm.nih.gov/pubmed/?term=Chen%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=26432036

http://www.ncbi.nlm.nih.gov/pubmed/?term=Cass%20SL%5BAuthor%5D&cauthor=true&cauthor_uid=26432036

http://www.ncbi.nlm.nih.gov/pubmed/?term=Kutty%20SK%5BAuthor%5D&cauthor=true&cauthor_uid=26432036

http://www.ncbi.nlm.nih.gov/pubmed/?term=Yee%20EM%5BAuthor%5D&cauthor=true&cauthor_uid=26432036

http://www.ncbi.nlm.nih.gov/pubmed/?term=Chan%20DS%5BAuthor%5D&cauthor=true&cauthor_uid=26432036

http://www.ncbi.nlm.nih.gov/pubmed/?term=Gardner%20CR%5BAuthor%5D&cauthor=true&cauthor_uid=26432036

http://www.ncbi.nlm.nih.gov/pubmed/?term=Vittorio%20O%5BAuthor%5D&cauthor=true&cauthor_uid=26432036

http://www.ncbi.nlm.nih.gov/pubmed/?term=Pasquier%20E%5BAuthor%5D&cauthor=true&cauthor_uid=26432036

http://www.ncbi.nlm.nih.gov/pubmed/?term=Black%20DS%5BAuthor%5D&cauthor=true&cauthor_uid=26432036

http://www.ncbi.nlm.nih.gov/pubmed/?term=Kumar%20N%5BAuthor%5D&cauthor=true&cauthor_uid=26432036

http://www.ncbi.nlm.nih.gov/pubmed/?term=Kumar%20N%5BAuthor%5D&cauthor=true&cauthor_uid=26432036


10. Cheng X; Hinde E; Owen DM; Lowe SB; Reece PJ; Gaus K; Gooding JJ, 2015, 'Enhancing QuantumDots for Bioimaging using Advanced Surface Chemistry and Advanced Optical Microscopy:Application to Silicon Quantum Dots (SiQDs)', AdvancedMaterials, http://dx.doi.org/10.1002/adma.201503223

11. Chilvers J; Kearnes MB, 2015, 'Public participation in science and technology: why the failure tolaunch?', The Guardian, https://www.theguardian.com/science/political-science/2015/dec/17/public-participation-science-technology-failure-to-launch

12. Choudhury MH; Ciampi S; Yang Y; Tavallaie R; Zhu Y; Zarei L; Gonçales VR; Gooding JJ, 2015,'Connecting electrodes with light: One wire, many electrodes', Chemical Science, vol. 6, no. 12, pp.6769 -6776, http://dx.doi.org/10.1039/c5sc03011k

13. Ciampi S; Choudhury MH; Ahmad SABA; Darwish N; Brun AL; Gooding JJ, 2015, 'The impact ofsurface coverage on the kinetics of electron transfer through redox monolayers on a siliconelectrode surface', Electrochimica Acta, vol. 186, pp. 216 -222, http://dx.doi.org/10.1016/j.electacta.2015.10.125

14. Cirillo G, Spizzirri UG, Curcio M, Hampel S, Vittorio O et al., 2015, ‘Carbon Nanohybrids as Electro-Responsive Drug Delivery Systems’, Mini reviews in medicinal chemistry (PMID:26156549).

15. Das T; Kutty SK; Tavallaie R; Ibugo AI; Panchompoo J; Sehar S; Aldous L; Yeung AWS; Thomas SR;Kumar N; Gooding JJ; Manefield M, 2015, 'Phenazine virulence factor binding to extracellular DNAis important for Pseudomonas aeruginosa biofilm formation', Scientific Reports, vol.5, http://dx.doi.org/10.1038/srep08398

16. Duong HTT; Dong Z; Su L; Boyer C; George J; Davis TP; Wang J, 2015, 'The use of nanoparticles todeliver nitric oxide to hepatic stellate cells for treating liver fibrosis and portalhypertension', Small, vol. 11, no. 19, pp. 2291 - 2304,http://dx.doi.org/10.1002/smll.201402870

17. Eakins GL; Pandey R; Wojciechowski JP; Zheng HY; Webb JEA; Valéry C; Thordarson P; PlankNOV; Gerrard JA; Hodgkiss JM, 2015, 'Functional Organic Semiconductors Assembled via NaturalAggregating Peptides', Advanced FunctionalMaterials, http://dx.doi.org/10.1002/adfm.201502255

18. Eakins GL; Wojciechowski JP; Martin AD; Webb JEA; Thordarson P; Hodgkiss JM, 2015, 'Chiraleffects in peptide-substituted perylene imide nanofibres', Supramolecular Chemistry, vol. 27, no.11-12, pp. 746 - 756, http://dx.doi.org/10.1080/10610278.2015.1066011

19. Gomez GA; McLachlan RW; Wu SK; Caldwell BJ; Moussa E; Verma S; Bastiani M; Priya R; PartonRG; Gaus K; Sap J; Yap AS, 2015, 'An RPTPα/Src family kinase/Rap1 signaling module recruitsmyosin IIB to support contractile tension at apical E-cadherin junctions', Molecular Biology of theCell, vol. 26, no. 7, pp. 1249 - 1262, http://dx.doi.org/10.1091/mbc.E14-07-1223

20. Graham D; Chamot-Rooke J; Gooding J; Kitamori T; Mao L; Masson J-F; Matousek P; Mizaikoff B;Soper S; Williams E; Wysocki V, 2015, 'Analyst Editorial Board profiles', The Analyst, vol. 140, no.1, pp. 18 - 21, http://dx.doi.org/10.1039/c4an90098g

21. Guo K; Soeriyadi AH; Feng H; Prévoteau A; Patil SA; Gooding JJ; Rabaey K, 2015, 'Heat-treatedstainless steel felt as scalable anode material for bioelectrochemical systems', BioresourceTechnology, http://dx.doi.org/10.1016/j.biortech.2015.06.060

22. Gupta B; Mai K; Lowe SB; Wakefield D; Di Girolamo N; Gaus K; Reece PJ; Gooding JJ, 2015,'Ultrasensitive and Specific Measurement of Protease Activity Using Functionalized PhotonicCrystals',Analytical Chemistry, vol. 87, no. 19, pp. 9946 -9953, http://dx.doi.org/10.1021/acs.analchem.5b02529

http://dx.doi.org/10.1002/adma.201503223

https://www.theguardian.com/science/political-science/2015/dec/17/public-participation-science-technology-failure-to-launch

https://www.theguardian.com/science/political-science/2015/dec/17/public-participation-science-technology-failure-to-launch

http://dx.doi.org/10.1016/j.electacta.2015.10.125

http://dx.doi.org/10.1038/srep08398

http://dx.doi.org/10.1002/smll.201402870

http://dx.doi.org/10.1002/adfm.201502255

http://dx.doi.org/10.1080/10610278.2015.1066011

http://dx.doi.org/10.1091/mbc.E14-07-1223

http://dx.doi.org/10.1039/c4an90098g

http://dx.doi.org/10.1021/acs.analchem.5b02529


23. Hassan MM; Martin AD; Thordarson P, 2015, 'Macromolecular crowding and hydrophobic effectson Fmoc-diphenylalanine hydrogel formation in PEG:water mixtures', Journal of MaterialsChemistry B, vol. 3, no. 48, pp. 9269 - 9276, http://dx.doi.org/10.1039/c5tb02139a

24. Healey RD; Prasad S; Rajendram V; Thordarson P, 2015, 'Unravelling the interaction between α-cyclodextrin with the thaumatin protein and a peptide mimic', Supramolecular Chemistry, vol. 27,pp. 414 - 419, http://dx.doi.org/10.1080/10610278.2014.956745

25. Howe ENW; Ball GE; Thordarson P, 2015, 'Step-by-step DFT analysis of the cooperativity in thebinding of cations and anions to a tetratopic ion-pairing host', Supramolecular Chemistry, vol. 27,no. 11-12, pp. 829 - 839, http://dx.doi.org/10.1080/10610278.2015.1088946

26. Jiang C; TanzirulAlam M; Parker SG; Gooding JJ, 2015, 'Zwitterionic Phenyl Phosphorylcholine onIndium Tin Oxide: A Low-Impedance Protein-Resistant Platform for Biosensing', Electroanalysis,http://dx.doi.org/10.1002/elan.201400557

27. Jing T; Ramji R; Warkiani ME; Han J; Lim CT; Chen CH, 2015, 'Jetting microfluidics with size-sorting capability for single-cell protease detection', Biosensors and Bioelectronics, vol. 66, pp. 19 -23, http://dx.doi.org/10.1016/j.bios.2014.11.001

28. Jung K; Xu J; Zetterlund PB; Boyer C, 2015, 'Visible-Light-Regulated Controlled/Living RadicalPolymerization in Miniemulsion', ACS Macro Letters, vol. 4, no. 10, pp. 1139 -1143, http://dx.doi.org/10.1021/acsmacrolett.5b00576

29. Kearnes MB, 2015, 'Growing the social life of soil', Australian PolicyOnline, http://dx.doi.org/10.4225/50/5668B815A9E22

30. Khoo BL; Lee SC; Kumar P; Tan TZ; Warkiani ME; Ow SGW; Nandi S; Lim CT; Thiery JP, 2015,'Short-term expansion of breast circulating cancer cells predicts response to anti-cancertherapy', Oncotarget, vol. 6, no. 17, pp. 15578 - 15593

31. Kim DS; Chang J; Leem S; Park JS; Thordarson P; Sessler JL, 2015, 'Redox- and pH-ResponsiveOrthogonal Supramolecular Self-Assembly: An Ensemble Displaying Molecular SwitchingCharacteristics', Journal of the American Chemical Society, vol. 137, no. 51, pp. 16038 -16042, http://dx.doi.org/10.1021/jacs.5b06524

32. Klotzsch E; Stiegler J; Ben-Ishay E; Gaus K, 2015, 'Do mechanical forces contribute to nanoscalemembrane organisation in T cells?', BBA: Molecular Cell Research, vol. 1853, no. 4, pp. 822 -829, http://dx.doi.org/10.1016/j.bbamcr.2014.10.025

33. Kurniawansyah F; Duong HTT; Luu TD; Mammucari R; Vittorio O; Boyer C; Foster N, 2015,'Inhalable curcumin formulations: Micronization and bioassay', Chemical Engineering Journal, vol.279, pp. 799 - 808, http://dx.doi.org/10.1016/j.cej.2015.05.087

34. Lee YY; Parker SG; Barfidokht A; Alam MT; Walker DB; Messerle BA; Gooding JJ, 2015, 'ARuthenium Based Organometallic Complex for Biosensing that is both a Stable Redox Label and aHomobifunctional Linker', Electroanalysis, vol. 27, no. 5, pp. 1078 -1085, http://dx.doi.org/10.1002/elan.201400642

35. Le-Masurier SP; Duong HTT; Boyer C; Granville AM, 2015, 'Surface modification of polydopaminecoated particles via glycopolymer brush synthesis for protein binding and FLIM testing', PolymerChemistry, vol. 6, no. 13, pp. 2504 - 2511, http://dx.doi.org/10.1039/c5py00062a

36. Li Y; Duong HTT; Laurent S; Macmillan A; Whan RM; Elst LV; Muller RN; Hu J; Lowe A; Boyer C;Davis TP, 2015, 'Nanoparticles based on star polymers as theranostic vectors: Endosomal-triggered drug release combined with mri sensitivity', Advanced healthcare materials, vol. 4, no. 1,pp. 148 - 156,http://dx.doi.org/10.1002/adhm.201400164

37. Liana DD; Raguse B; Gooding JJ; Chow E, 2015, 'Toward Paper-Based Sensors: Turning ElectricalSignals into an Optical Readout System', ACS Applied Materials and Interfaces, vol. 7, no. 34, pp.19201 - 19209, http://dx.doi.org/10.1021/acsami.5b04941

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http://dx.doi.org/10.1016/j.bios.2014.11.001

http://dx.doi.org/10.1021/acsmacrolett.5b00576

http://dx.doi.org/10.4225/50/5668B815A9E22

http://dx.doi.org/10.1021/jacs.5b06524

http://dx.doi.org/10.1016/j.bbamcr.2014.10.025

http://dx.doi.org/10.1016/j.cej.2015.05.087

http://dx.doi.org/10.1002/elan.201400642

http://dx.doi.org/10.1039/c5py00062a

http://dx.doi.org/10.1002/adhm.201400164

http://dx.doi.org/10.1021/acsami.5b04941


38. Liu K; Zheng Y; Lu X; Thai T; Lee NA; Bach U; Gooding JJ, 2015, 'Biocompatible gold nanorods:One-step surface functionalization, highly colloidal stability, and low cytotoxicity', Langmuir: theACS journal of surfaces and colloids, vol. 31, no. 17, pp. 4973 -4980, http://dx.doi.org/10.1021/acs.langmuir.5b00666

39. Lu Y; Peterson JR; Gooding JJ; Lee NA, 2015, 'Development of a Competitive ELISA for theDetection of 4-tert-Octylphenol in Seafood', Food Analytical Methods, vol. 8, no. 8, pp. 1923 -1935, http://dx.doi.org/10.1007/s12161-014-0053-y

40. Lu Y; Peterson JR; Luais E; Gooding JJ; Lee NA, 2015, 'Surface Epitope Coverage Affects BindingCharacteristics of Bisphenol-A Functionalized Nanoparticles in a Competitive InhibitionAssay', Journal of Nanomaterials, vol. 2015, http://dx.doi.org/10.1155/2015/756056

41. Jing T; Ramji R; Warkiani ME; Han J; Lim CT; Chen CH, 2015, 'Jetting microfluidics with size-sorting capability for single-cell protease detection', Biosensors and Bioelectronics, vol. 66, pp. 19 -23, http://dx.doi.org/10.1016/j.bios.2014.11.001

42. Jung K; Xu J; Zetterlund PB; Boyer C, 2015, 'Visible-Light-Regulated Controlled/Living RadicalPolymerization in Miniemulsion', ACS Macro Letters, vol. 4, no. 10, pp. 1139 -1143, http://dx.doi.org/10.1021/acsmacrolett.5b00576

43. Magenau A; Owen DM; Yamamoto Y; Tran J; Kwiatek JM; Parton RG; Gaus K, 2015, 'Discreet anddistinct clustering of five model membrane proteins revealed by single molecule localizationmicroscopy', Molecular Membrane Biology, vol. 32, no. 1, pp. 11 -18, http://dx.doi.org/10.3109/09687688.2014.990997

44. Makharza S, Vittorio O, Cirillo G, Oswald S, Hinde E, Kavallaris M et al., 2015, ‘Graphene Oxide-Gelatin Nanohybrids as Functional Tools for Enhanced Carboplatin Activity in NeuroblastomaCells’, Pharmaceutical research 2015:32:6:2132-2143.

45. Martin AD; Robinson AB; Thordarson P, 2015, 'Biocompatible small peptide super-hydrogelatorsbearing carbazole functionalities', Journal of Materials Chemistry B, vol. 3, no. 11, pp. 2277 -2280, http://dx.doi.org/10.1039/c5tb00067j

46. McCarroll, J. A., Dwarte, T., Baigude, H., Dang, J., Yang, L., Erlich, R. B., Kimpton, K., Teo, J., Sagnella,S. M., Akerfeldt, M. C., Liu, J., Phillips, P. A., Rana, T. M., and Kavallaris, M. (2015) Therapeutictargeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment ofnon-small cell lung cancer, Oncotarget 6, 12020-12034.

47. McCarroll, J. A., Gan, P. P., Erlich, R. B., Liu, M., Dwarte, T., Sagnella, S. S., Akerfeldt, M. C., Yang, L.,Parker, A. L., Chang, M. H., Shum, M. S., Byrne, F. L., and Kavallaris, M. (2015) TUBB3/βIII-tubulinacts through the PTEN/AKT signaling axis to promote tumorigenesis and anoikis resistance innon-small cell lung cancer, Cancer Research 75, 415-425.

48. McCarroll, J. A., Sharbeen, G., Liu, J., Youkhana, J., Goldstein, D., McCarthy, N., Limbri, L. F., Dischl,D., Ceyhan, G. O., Erkan, M., Johns, A. L., Biankin, A. V., Kavallaris, M., and Phillips, P. A. (2015) βIII-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer, Oncotarget 6,2235-2249.

49. Nguyen D; Boyer C, 2015, 'Macromolecular and Inorganic Nanomaterials Scaffolds for CarbonMonoxide Delivery: Recent Developments and Future Trends', ACS biomaterials science &engineering, vol. 1, no. 10, pp. 895 - 913, http://dx.doi.org/10.1021/acsbiomaterials.5b00230

50. Nguyen D; Nguyen TK; Rice SA; Boyer C, 2015, 'CO-releasing polymers exert antimicrobialactivity', Biomacromolecules, vol. 16, no. 9, pp. 2776 -2786, http://dx.doi.org/10.1021/acs.biomac.5b00716

http://dx.doi.org/10.1021/acs.langmuir.5b00666

http://dx.doi.org/10.1007/s12161-014-0053-y

http://dx.doi.org/10.1155/2015/756056

http://dx.doi.org/10.1016/j.bios.2014.11.001


http://dx.doi.org/10.3109/09687688.2014.990997

http://dx.doi.org/10.1039/c5tb00067j

http://dx.doi.org/10.1021/acsbiomaterials.5b00230

http://dx.doi.org/10.1021/acs.biomac.5b00716


51. Nguyen TK; Duong HTT; Selvanayagam R; Boyer C; Barraud N, 2015, 'Iron oxide nanoparticle-mediated hyperthermia stimulates dispersal in bacterial biofilms and enhances antibioticefficacy', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep18385

52. Pandžić E; Rossy J; Gaus K, 2015, 'Tracking molecular dynamics without tracking: Imagecorrelation of photo-activation microscopy', Methods and Applications in Fluorescence, vol. 3, no.1,http://dx.doi.org/10.1088/2050-6120/3/1/014006

53. Parker SG; Gooding JJ, 2015, 'Single-cell isolation devices: Understanding the behaviour of cells',Journal and Proceedings of the Royal Society of New South Wales, vol. 148, no. 455-456, pp. 70 - 81

54. Pasquier, E., Tuset, M. P., Sinnappan, S., Carnell, M., Macmillan, A., and Kavallaris, M. (2015) γ-Actin plays a key role in endothelial cell motility and neovessel maintenance, Vascular Cell 7.

55. Pham S; Tabarin T; Garvey M; Pade C; Rossy J; Monaghan P; Hyatt A; Böcking T; Leis A; Gaus K;Mak J, 2015, 'Cryo-electron microscopy and single molecule fluorescent microscopy detect CD4receptor induced HIV size expansion prior to cell entry', Virology, vol. 486, pp. 121 -133, http://dx.doi.org/10.1016/j.virol.2015.09.006

56. Qiao H; Soeriyadi AH; Guan B; Reece PJ; Gooding JJ, 2015, 'The analytical performance of a poroussilicon Bloch surface wave biosensors as protease biosensor', Sensors and Actuators B: Chemical:international journal devoted to research and development of physical and chemical transducers,vol. 211, pp. 469- 475, http://dx.doi.org/10.1016/j.snb.2015.01.098

57. Rahman S; Zein A; Dawe LN; Shamov G; Thordarson P; Georghiou PE, 2015, 'Supramolecularhost-guest complexation of Lash's calix[4]azulene with tetraalkylammonium halides andtetrafluoroborate salts: binding and DFT computational studies', RSC Advances, vol. 5, no. 68, pp.54848 - 54852, http://dx.doi.org/10.1039/c5ra07802d

58. Sevimli, S., Sagnella, S., Macmillan, A., Whan, R., Kavallaris, M., Bulmus, V., and Davis, T. P. (2015)The endocytic pathway and therapeutic efficiency of doxorubicin conjugated cholesterol-derivedpolymers, Biomaterials Science 3, 323-335.

59. Shanmugam S; Boyer C, 2015, 'Stereo-, Temporal and Chemical Control through Photoactivationof Living Radical Polymerization: Synthesis of Block and Gradient Copolymers', Journal of theAmerican Chemical Society, vol. 137, no. 31, pp. 9988 -9999, http://dx.doi.org/10.1021/jacs.5b05903

60. Shanmugam S; Xu J; Boyer C, 2015, 'Exploiting Metalloporphyrins for Selective Living RadicalPolymerization Tunable over Visible Wavelengths', Journal of the American Chemical Society, vol.137, no. 28, pp. 9174 – 9185, http://dx.doi.org/10.1021/jacs.5b05274

61. Shanmugam S; Xu J; Boyer C, 2015, 'Utilizing the electron transfer mechanism of chlorophyll aunder light for controlled radical polymerization', Chemical Science, vol. 6, no. 2, pp. 1341 -1349, http://dx.doi.org/10.1039/c4sc03342f

62. Shemesh J; Jalilian I; Shi A; Heng Yeoh G; Knothe Tate ML; Ebrahimi Warkiani M, 2015, 'Flow-induced stress on adherent cells in microfluidic devices', Lab On a Chip: microfluidic andnanotechnologies for chemistry, biology, and bioengineering, vol. 15, no. 21, pp. 4114 -4127, http://dx.doi.org/10.1039/c5lc00633c

63. Shemesh J; Jalilian I; Shi A; Yeoh GH; Knothe Tate ML; Warkiani ME, 2015, 'Erratum: Outside backcover (volume 15, issue 21) (Lab on a Chip - Miniaturisation for Chemistry and Biology (2015) 15(4234))', Lab On a Chip: microfluidic and nanotechnologies for chemistry, biology, andbioengineering, vol. 15, no. 24, pp. 4627, http://dx.doi.org/10.1039/c5lc90125a

64. Spizzirri UG, Curcio M, Cirillo G, Spataro T, Vittorio O, Picci N, 2015, ‘Recent advances in thesynthesis and biomedical applications of nanocomposite hydrogels’, Pharmaceutics 2015, 7(4),413-437


http://dx.doi.org/10.1088/2050-6120/3/1/014006

http://dx.doi.org/10.1016/j.virol.2015.09.006

http://dx.doi.org/10.1016/j.snb.2015.01.098

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65. Sriram M; Zong K; Vivekchand SRC; Justin Gooding J, 2015, 'Single nanoparticle plasmonicsensors',Sensors, vol. 15, no. 10, pp. 25774 - 25792, http://dx.doi.org/10.3390/s151025774

66. Taufik S; Barfidokht A; Alam MT; Jiang C; Parker SG; Gooding JJ, 2015, 'An antifouling electrodebased on electrode-organic layer-nanoparticle constructs: Electrodeposited organic layers versusself-assembled monolayers', Journal of ElectroanalyticalChemistry, http://dx.doi.org/10.1016/j.jelechem.2016.01.031

67. Tavallaie R; Darwish N; Brynn Hibbert D; Justin Gooding J, 2015, 'Nucleic-acid recognitioninterfaces: How the greater ability of RNA duplexes to bend towards the surface influenceselectrochemical sensor performance', Chemical Communications, vol. 51, no. 92, pp. 16526 -16529, http://dx.doi.org/10.1039/c5cc05450h

68. Tavallaie R; De Almeida SRM; Gooding JJ, 2015, 'Toward biosensors for the detection ofcirculating microRNA as a cancer biomarker: An overview of the challenges and successes', Wileyinterdisciplinary reviews. Nanomedicine and nanobiotechnology, vol. 7, no. 4, pp. 580 -592, http://dx.doi.org/10.1002/wnan.1324

69. Thomassen PJ; Varghese S; Bijsterveld EJA; Thordarson P; Elemans JAAW; Rowan AE; Nolte RJM,2015, 'A Double-Cavity-Containing Porphyrin Host as a Highly Stable EpoxidationCatalyst', European Journal of Organic Chemistry, vol. 2015, no. 23, pp. 5246 -5253, http://dx.doi.org/10.1002/ejoc.201500492

70. Tregubov AA; Walker DB; Vuong KQ; Gooding JJ; Messerle BA, 2015, 'The advantages ofcovalently attaching organometallic catalysts to a carbon black support: Recyclable Rh(I)complexes that deliver enhanced conversion and product selectivity', Dalton Transactions: aninternational journal of inorganic chemistry, vol. 44, no. 17, pp. 7917 -7926, http://dx.doi.org/10.1039/c5dt00409h

71. Truong WT; Su Y; Gloria D; Braet F; Thordarson P, 2015, 'Dissolution and degradation of Fmoc-diphenylalanine self-assembled gels results in necrosis at high concentrations invitro', Biomaterials Science, vol. 3, no. 2, pp. 298 - 307, http://dx.doi.org/10.1039/c4bm00244j

72. Warkiani ME; Tay AKP; Guan G; Han J, 2015, 'Membrane-less microfiltration using inertialmicrofluidics', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep11018

73. Warkiani ME; Tay AKP; Khoo BL; Xiaofeng X; Han J; Lim CT, 2015, 'Malaria detection usinginertial microfluidics', Lab On a Chip: microfluidic and nanotechnologies for chemistry, biology, andbioengineering, vol. 15, no. 4, pp. 1101 - 1109, http://dx.doi.org/10.1039/c4lc01058b

74. Warkiani ME; Wicaksana F; Fane AG; Gong HQ, 2015, 'Investigation of membrane fouling at themicroscale using isopore filters', Microfluidics and Nanofluidics, vol. 19, no. 2, pp. 307 -315, http://dx.doi.org/10.1007/s10404-014-1538-0

75. Wong CK; Laos AJ; Soeriyadi AH; Wiedenmann J; Curmi PMG; Gooding JJ; Marquis CP; Stenzel MH;Thordarson P, 2015, 'Polymersomes prepared from thermoresponsive fluorescent protein-polymer bioconjugates: Capture of and report on drug and protein payloads', Angewandte ChemieInternational Edition, vol. 54, no. 18, pp. 5317 – 5322,http://dx.doi.org/10.1002/anie.201412406

76. Wong CK; Laos AJ; Soeriyadi AH; Wiedenmann J; Curmi PMG; Gooding JJ; Marquis CP; Stenzel MH;Thordarson P, 2015, 'Polymersomes prepared from thermoresponsive fluorescent protein-polymer bioconjugates: Capture of and report on drug and protein payloads', Angewandte ChemieInternational Edition, http://dx.doi.org/10.1002/anie.201412406

77. Xu J; Boyer C, 2015, 'Visible light photocatalytic thiol-ene reaction: An elegant approach for fastpolymer postfunctionalization and step-growth polymerization', Macromolecules, vol. 48, no. 3,pp. 520-529, http://dx.doi.org/10.1021/ma502460t

http://dx.doi.org/10.3390/s151025774

http://dx.doi.org/10.1016/j.jelechem.2016.01.031

http://dx.doi.org/10.1039/c5cc05450h

http://dx.doi.org/10.1002/wnan.1324

http://dx.doi.org/10.1002/ejoc.201500492

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http://dx.doi.org/10.1039/c4lc01058b

http://dx.doi.org/10.1007/s10404-014-1538-0

http://dx.doi.org/10.1002/anie.201412406

http://dx.doi.org/10.1002/anie.201412406

http://dx.doi.org/10.1021/ma502460t


78. Xu J; Shanmugam S; Boyer C, 2015, 'Organic Electron Donor-Acceptor Photoredox Catalysts:Enhanced Catalytic Efficiency toward Controlled Radical Polymerization', ACS Macro Letters, vol.4, no. 9, pp. 926 - 932 http://dx.doi.org/10.1021/acsmacrolett.5b00460

79. Xu J; Shanmugam S; Duong HT; Boyer C, 2015, 'Organo-photocatalysts for photoinduced electrontransfer-reversible addition- fragmentation chain transfer (PET-RAFT) polymerization', PolymerChemistry, vol. 6, no. 31, pp. 5615 – 5624, http://dx.doi.org/10.1039/c4py01317d

80. Yaffe Y; Hugger I; Yassaf IN; Shepshelovitch J; Sklan EH; Elkabetz Y; Yeheskel A; Pasmanik-ChorM; Benzing C; Macmillan A; Gaus K; Eshed-Eisenbach Y; Peles E; Hirschberg K, 2015, 'The myelinproteolipid plasmolipin forms oligomers and induces liquid-ordered membranes in the Golgicomplex',Journal of Cell Science, vol. 128, no. 13, pp. 2293-2302, http://dx.doi.org/10.1242/jcs.166249

81. Yeow J; Xu J; Boyer C, 2015, 'Polymerization-Induced Self-Assembly Using Visible Light MediatedPhotoinduced Electron Transfer-Reversible Addition-Fragmentation Chain TransferPolymerization',ACS Macro Letters, vol. 4, no. 9, pp. 984 -990 http://dx.doi.org/10.1021/acsmacrolett.5b00523

82. Zhang X; Li Q; Jin X; Jiang C; Lu Y; Tavallaie R; Gooding JJ, 2015, 'Quantitative determination oftarget gene with electrical sensor', Scientific Reports, vol.5, http://dx.doi.org/10.1038/srep12539

83. Zheng Y; Soeriyadi AH; Rosa L; Ng SH; Bach U; Justin Gooding J, 2015, 'Reversible gating of smartplasmonic molecular traps using thermoresponsive polymers for single-molecule detection’,Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms9797

Left: Cover of January 2016 Inaugural Issue of ACS Sensors

ACN Centre Director Scientia Professor Justin Gooding was appointed Inaugural Editor-in-Chief of the American Chemical Society journal, ACS Sensors, 2015-.

This appointment was made after an international search of Editors in Chief of other ACS journals whereupon Professor Gooding was approached. This is the first time the American Chemical Society, the most prestigious publisher in chemistry, has had an editor-in-chief from outside the US or Europe.


http://dx.doi.org/10.1039/c4py01317d

http://dx.doi.org/10.1242/jcs.166249



http://dx.doi.org/10.1038/ncomms9797


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Australian Centre for NanoMedicine Annual Report 2015 · Professor Merlin Crossley, Dean of...

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