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HEALTH • NUTRITION • MATERIALS

DSM ProteaseFor further information, please see:www.dsmnutritionalproducts.com or contact:

DSM Nutritional Products LtdPO Box 2676, CH-4002 Basel, Switzerland

©DSM 2012

DISCLAIMERAlthough DSM has used diligent care to ensure that the information provided herein is accurate and up to date, DSM makes no representation or warranty of the accuracy, reliability, or completeness of the information. The information provided herein is for informational purposes and is intended for business to business useonly. This publication does not constitute or provide scientific or medical advice, diagnosis, or treatment and is distributed without warranty of any kind, either expressly or implied. In no event shall DSM be liable for any damages arising from the reader's reliance upon, or use of, these materials. The reader shall besolely responsible for any interpretation or use of the material contained herein. The content of this document is subject to change without further notice. Please contact your local DSM representative for more details. All trademarks listed in this brochure are either registered trademarks or trademarks of DSM in The Netherlands and/or other countries.

March 2012

Patented

RONOZYME® ProAct - maximize your proteins

DSM Protease - RONOZYME® ProAct 4

Novozymes has patents covering the combinationof any Phytase and Protease in broiler feeds(U.S. Patent 5,989,600 and European patents EP 0,756,457 B2 and EP1,142,485 B1) and theuse thereof for improving digestibility of proteins.Any marketing and promotion of a Protease together with a Phytase for use in broiler dietsinfringes Novozymes’ US and EU patents.

In case of usage of any other feed phytase together with a feed protease or a feed enzymewith protease activity claim other than RONOZYME® Phytases and RONOZYME® ProActtogether, please contact DSM Nutritional Products for a specific grant of license in USA and EU.

RONOZYME® - Your first choice for feed enzymes

366036403620

3780 1.511.501.491.481.471.461.451.44

3760374037203700

Improved apparent digestibility of amino acids Improved true digestibility of amino acids

3680 105%

Soya-BR*Soya-BR**Soya-US***

RONOZYME® ProAct improves the apparent and true digestibility of amino acids in a broiler diet

Positive impact of RONOZYME®ProAct onperformance of broilers fed diets reducedin amino acids and crude protein

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011

1960 1970 1980 1990 2000Year

2010 2020 2030 2040 2050

Source: US Census Bureau, International Data Base, Dec 2008 update.

World population

Soybeans price chart

T2 T3 Met Cys M+C Lys Thr Val lle

Feather mealFish meal

Meat and bone mealSoybean meal 44Cotton seed meal

Rape seed mealSunflower meal

Lupine (Kol-lupine)Pea

MaizeBarley

TriticaleWheat

SorgumRye

% relative improvement over control containing only endogenous digestive enzymes--10 20

Liveweight FCR

T1: Positive control, standard dietary nutrient contentT2: Negative control, reduced crude protein (-3%) and amino acid (-3%)

from 0-42 daysT3: T2 supplemented with RONOZYME®ProAct

Amino Acids

42 days

SAC July 2011 * Bertechini et al., 2009 **Messias et al., 2010 ***Angel et al., 2011

Messias et al, UFL, 2010

* ** *

* * * * * ** *

* * * *

Glu Ser Gly His Arg Thr Ala Pro Tyr Val M+C LLe Leu Phe Lys

P<0.05

RONOZYME® designates the unique global FeedEnzymes Alliance between DSM and Novozymes– both preeminent leaders in their field and committed to success based on collaboration and innovation.

By pooling their market and technical expertise,extensive experience and a focus on quality, the Alliance has developed the broadest range of innovative feed enzyme products to counter highly variable feed costs in a sustainable way.

All products under the brand name RONOZYME®

are backed by comprehensive and independent scientific research of the highest level to confirmefficacy, reliability and safety in a wide range offeed manufacturing situations and applications.DSM and Novozymes are committed to setting theindustry standards for feed enzyme formulationand product performance.

The companies share activities, and build on individual strengths to deliver outstanding products and innovative solutions.

Novozymes provides knowhow in enzyme screening,strain development, formulation, and production,while DSM brings expertise of animal nutritionand feed technology, as well as a global reach inpremix manufacture and sales and marketing.

RONOZYME® ProAct - Maximize your proteins

RONOZYME® ProAct has been developed: • To hydrolyze proteins in diets by complementing

the naturally produced proteases in the digestive tract of farm animals

• To provide extra power to utilize more protein,making more peptides and free amino acidsavailable to the animal.

• To effectively target a very broad range of feed protein sources.

• To complement the performance of all otherendogenous and exogenous enzymes.

Research shows that RONOZYME® ProAct improvesthe apparent and true digestibility of all principalamino acids when added to a corn and soybeanmeal based diet.

RONOZYME® ProAct is the moststable feed protease.RONOZYME® ProAct is stable throughout the intestinal tract, and supplements the performance of other feed enzymes such as carbohydrases and phytases. RONOZYME® ProActhas outstanding stability in all feed applications,including premixes and pelleted feeds. Trials show high levels of recovery under commercial feed production conditions.

The dust-free formulation ensures there are nosafety issues while being incorporated in feed.

RONOZYME® ProAct increases the efficiency of livestock production by improving protein utilization in a wide range of feed ingredients.RONOZYME® ProAct is a real solution to the challenges in the economics of meat production,and ultimately boosts producer profitability in the quest for sustainable meat production.

The proven solution to all these issues is the inclusion of a specificly selected protease RONOZYME® ProAct that is optimized for animalnutrition - improving protein digestibility and optimizing feed cost. The improved protein utilization also reduces nitrogen excretion and theenvironmental impact of livestock production.

Proteases are enzymes which breakdown complexprotein molecules into the usable amino acids andpeptides. Although proteases occur naturally in thedigestive system of all classes of livestock, addition of a specific exogenous protease could

improve the protein digestibility of a broad range offeed ingredients, especially lower quality proteinstypically not used for human consumption.

RONOZYME® ProAct increases digestibility of protein,and ensures more amino acids are available tothe animal. The amount of nitrogen excreted isdecreased. Ultimately this can increase the opportunity to use cheaper feed materials and soreduce feed costs. Alternatively, the protein content in the diet can be reduced while still maintaining animal performance.

Protein - a mounting global concernThe world is facing a rapidly expanding demandfor quality protein from animal sources, driven bytwo major factors:• More people. By 2050 the human population is

expected to reach 9 billion people, a doublingin just over 60 years.

• Higher demand for animal and feed protein.

Families with higher incomes want a healthierdiet. This is particularly true in the high growtheconomies.

The challenge to the livestock production industryis two fold:• To produce extra meat with increasingly limited

resources• To do so at a price affordable to the consumer

To meet these challenges, farmers will have to usefeed, and particularly protein ingredients, moreefficiently. Protein is one of the most expensive rawmaterials in an animal’s diet but is essential forgrowth. As demand for protein sources increases,the price is expected to continue to rise. The challenge is how to utilize protein sourcesmore effectively, or how to stretch less further.

Whether you require a specific

enzyme or a carefully selected blend,

you need look no further than

RONOZYME®.