9/4/2015 Arctigeninprotectsfocalcerebralischemiareperfusionratsthroughinhibitingneuroinflammation.PubMedNCBI

http://www.ncbi.nlm.nih.gov/pubmed/22972486 1/2

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BiolPharmBull.201235(11):20049.Epub2012Aug22.

Arctigeninprotectsfocalcerebralischemiareperfusionratsthroughinhibitingneuroinflammation.FanT ,JiangWL,ZhuJ,FengZhangY.

AbstractStrokeisthethirdleadingcauseofdeathinindustrializedcountriesandthemostimportantcauseofacquiredadultdisability.Manyevidencessuggestthatinflammationaccountsfortheprogressionofcerebralischemicinjury.Arctigenin,aphenylpropanoiddibenzylbutyrolactoneligninisolatedfromcertainplants,hasshownantiinflammatoryactivityagainstdiabetesandAlzheimer'sdisease.Inthisstudy,wetestedwhetherarctigenincanprotectmiddlecerebralarteryoccluded(MCAO)rats.MaleSpragueDawleyratswerepretreatedwitharctigeninorvehiclefor7dbeforebeingsubjectedtotransientocclusionofmiddlecerebralarteryandreperfusion.Ratswereevaluatedat24hafterMCAOforneurologicaldeficitscoring.Furthermore,themechanismoftheantiinflammatoryeffectofarctigeninwasinvestigatedwithafocusoninflammatorycells,proinflammatorycytokines,andtranscriptionalfactors.Arctigeninsignificantlyreducedcerebralinfarctionandimprovedneurologicaloutcome.Arctigeninsuppressedtheactivationofmicrogliaanddecreasedtheexpressionofinterleukin(IL)1andtumornecrosisfactor(TNF).Theseresultsrevealedthatarctigeninhasapromisingtherapeuticeffectinischemicstroketreatmentthroughanantiinflammatorymechanism.

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9/4/2015 Arctigeninprotectsfocalcerebralischemiareperfusionratsthroughinhibitingneuroinflammation.PubMedNCBI

http://www.ncbi.nlm.nih.gov/pubmed/22972486 2/2