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Application of Conditioning to the Study of Drug Addiction
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Transcript of Application of Conditioning to the Study of Drug Addiction
Application of Conditioning to the Study of Drug Addiction
Self-Administration of drugs of abuse uses Instrumental conditioning procedures
R SR
e.g. Lever press response drug delivery
Conditioned Place Preference with drugs of abuse uses Pavlovian conditioning procedures
CS * UCS R CS R
e.g. Light Stimulus*Drug approach response
Light Stimulus approach response
Pre-conditioningPreference Tests
Days 1 and 2
ConditioningSessionsDays 3-10
Post-conditioningPreference TestsDays 11 and 14
Conditioned Place Preference
Drug-injected
Not Drug-injected
stay
don’t
stay
Intravenous Cocaine Self-Administration
d-Amphetamine
Cocaine Chlordiazepoxide
Codeine
Diazepam
Ethanol
Fentanyl
Heroin
KetamineMethadoneMethamphetamine
Methylphenidate
Morphine
Nicotine
Pentobarbital
Phencyclidine (PCP)
9 THC
Some drugs that are self-administered by laboratory animals
Stimulants Narcotics Anxiolytics Other
Cocaine + Cocaine Cues
No Cocaine and No Cues
Cocaine Cues Alone
Self-Administration Model of Relapse incorporates both Instrumental and Pavlovian Conditioning
Cue-Induced Relapse to Cocaine-Seeking Behavior
Nature Video Cocaine Video
Front of Brain
Back of Brain
Amygdalanot lit up
Amygdalaactivated
Childress et al 1999Cocaine Cue-Induce Craving
Grant et al 1996Cocaine Cue-Induce Craving
In the laboratory......
• Study the brain sites that mediate conditioned relapse-like behavior
• Determine the molecules that give rise to conditioned relapse-like behavior (e.g., genes; proteins)
• Test medications that may reduce conditioned relapse-like behavior
• Study the consequences of conditioned drug use (e.g., neurocognitive; brain plasticity changes)