Aplicable DiseaseAplicable Disease

World Health Organization 1997World Health Organization 1997 Atherosclerosis and its consequences

(ASPVD, ASCAD, ASCVD) and Cancer together are responsible for over 80% of ALL deaths in industrialized countries

Atherosclerosis and its consequences (ASPVD, ASCAD, ASCVD) and Cancer together are responsible for over 80% of ALL deaths in industrialized countries

“Cardiovascular Drug Therapy”1996“Cardiovascular Drug Therapy”1996

Martin Rubin PhDMartin Rubin PhD

Metal Toxicity & Heart DiseaseMetal Toxicity & Heart Disease Chapter 175 MagnesiumEDTA chelation

Martin Rubin PhD EDTA acts as an anti-oxidant, anti-

coagulant and decalcifies deposits. 30 infusions of EDTA in a patient 14 years

post MI and multi-vessel CABG. Ultrafast CT scan showed 216 calcified lesions and total calcium score of 15872. Post chelation: 118 lesions, calcium score 7970

Chapter 175 MagnesiumEDTA chelation Martin Rubin PhD

EDTA acts as an anti-oxidant, anti-coagulant and decalcifies deposits.

30 infusions of EDTA in a patient 14 years post MI and multi-vessel CABG. Ultrafast CT scan showed 216 calcified lesions and total calcium score of 15872. Post chelation: 118 lesions, calcium score 7970

Prof. Martin RubinProf. Martin Rubin

Metal Toxicity & Heart DiseaseMetal Toxicity & Heart Disease “EDTA chelation has an implicit

advantage in that it can favorably influence all facets of the (atherosclerotic) disease development. Thus it can also provide an alternative to the combination of drugs administered to obtain a multiplicity of therapeutic effects.”

“EDTA chelation has an implicit advantage in that it can favorably influence all facets of the (atherosclerotic) disease development. Thus it can also provide an alternative to the combination of drugs administered to obtain a multiplicity of therapeutic effects.”

Metal Toxicity & Heart DiseaseMetal Toxicity & Heart Disease

Journal of American College of Cardiology, 1999Journal of American College of Cardiology, 1999

Metal Toxicity & Heart DiseaseMetal Toxicity & Heart DiseaseIdiopathic Dilated Cardiomyopathy Hg – 22,000 x normal Sb – 12,000 x normal Au – 11 x normal Cr – 13 x normal Co – 4 x normal

Idiopathic Dilated Cardiomyopathy Hg – 22,000 x normal Sb – 12,000 x normal Au – 11 x normal Cr – 13 x normal Co – 4 x normal

Metal Toxicity & PVDMetal Toxicity & PVD

Metal Toxicity & PVDMetal Toxicity & PVD 79 year old woman - Presenting History 1979 NIDDM and hypertension 1992 Mastectomy for breast carcinoma 1993 Increasing PVD 1996 Left hemiplegia CVA 1997 March - Severe pain in left foot at rest.

Hospitalized but refused angiogram and possible amputation. Started chelation. Medications: Minidiab, Adalat, Quinine sulphate, Warfarin

79 year old woman - Presenting History 1979 NIDDM and hypertension 1992 Mastectomy for breast carcinoma 1993 Increasing PVD 1996 Left hemiplegia CVA 1997 March - Severe pain in left foot at rest.

Hospitalized but refused angiogram and possible amputation. Started chelation. Medications: Minidiab, Adalat, Quinine sulphate, Warfarin

Became pain-free with improved circulation after 6 weeks of chelation.

Discharged from the hospital vascular clinic after 6 months.

Maintained on monthly chelations for 4 years

Became pain-free with improved circulation after 6 weeks of chelation.

Discharged from the hospital vascular clinic after 6 months.

Maintained on monthly chelations for 4 years

Metal Toxicity & PVDMetal Toxicity & PVD 3 blinded controlled trials

- Olszewer and Carter—10 patients crossover

- Van Rij—32 patients, slight improvement, one major outlier

- Guldagger—51% vs. 24% improved Underpowered, 1/3 dropout Statistical problems Patients continued to smoke Did not follow the standard protocol as claimed

3 blinded controlled trials- Olszewer and Carter—10 patients

crossover- Van Rij—32 patients, slight improvement,

one major outlier- Guldagger—51% vs. 24% improved

Underpowered, 1/3 dropout Statistical problems Patients continued to smoke Did not follow the standard protocol as claimed

Metal Toxicity & Vascular DiseaseMetal Toxicity & Vascular DiseaseMulti-Centered Trial 220 patients with documented vascular

disease Received chelation with three year follow-

up No deaths or MIs, 4 minor strokes Symptoms improved Chappell, Mitchell, Born, Ventresco,

Hancke, Olszewer, van der Schaar, Blaha

Multi-Centered Trial 220 patients with documented vascular

disease Received chelation with three year follow-

up No deaths or MIs, 4 minor strokes Symptoms improved Chappell, Mitchell, Born, Ventresco,

Hancke, Olszewer, van der Schaar, Blaha

Metal Toxicity & Vascular DiseaseMetal Toxicity & Vascular DiseaseMulti-Centered Trial Compared to conventional therapies

- Expected 31/220 angioplasties, we had 2

- Expected 16/220 CABG, we had 6

- Expected 15/220 MI’s, we had none

- Expected 6/220 deaths, we had none

- Of 185 patients with symptoms, 68% had a complete resolution

Multi-Centered Trial Compared to conventional therapies

- Expected 31/220 angioplasties, we had 2

- Expected 16/220 CABG, we had 6

- Expected 15/220 MI’s, we had none

- Expected 6/220 deaths, we had none

- Of 185 patients with symptoms, 68% had a complete resolution

Ali M, et al. J Integrative Med.1997;1:7-112Ali M, et al. J Integrative Med.1997;1:7-112

Metal Toxicity & MIMetal Toxicity & MI Improved myocardial perfusion in

patients with advanced ischemic heart disease with an integrative management program including EDTA metal binding therapy.

Improved myocardial perfusion in patients with advanced ischemic heart disease with an integrative management program including EDTA metal binding therapy.

Metal Toxicity & MIMetal Toxicity & MI Comparative study of pre- and post-

chelation myocardial thallium perfusion scans showed clear, objective evidence of significant improvement in myocardial perfusion in five of six patients in whom such studies were performed

Comparative study of pre- and post-chelation myocardial thallium perfusion scans showed clear, objective evidence of significant improvement in myocardial perfusion in five of six patients in whom such studies were performed

Metal Toxicity & Heart DiseaseMetal Toxicity & Heart Disease EDTA Chelation Therapy in Myocardial

Stunning and Hibernation. Edwards D, et al. J.Adv.Med 1997;10,4:233-257

5 Case Reports All patients were studied using first-

pass radionuclide ventriculography (RNV) All ejection fractions improved

EDTA Chelation Therapy in Myocardial Stunning and Hibernation. Edwards D, et al. J.Adv.Med 1997;10,4:233-257

5 Case Reports All patients were studied using first-

pass radionuclide ventriculography (RNV) All ejection fractions improved

Metal Toxicity & Heart DiseaseMetal Toxicity & Heart Disease Conclusion: EDTA Metal Binding

Therapy clearly and convincingly reverses the condition of myocardial hibernation and possibly stunning

Conclusion: EDTA Metal Binding Therapy clearly and convincingly reverses the condition of myocardial hibernation and possibly stunning

Metal Toxicity & ANGINAMetal Toxicity & ANGINA Kitchell and Meltzer-- small controlled

trial, and 71% of 38 patients with disabling angina improved symptoms and exercise capacity

Hancke and Flytlie—69% of 253 patients improved EKG and exercise capacity, 91% of 207 patients on NTG stopped it, 58/65 on waiting list for Bypass avoided surgery

Kitchell and Meltzer-- small controlled trial, and 71% of 38 patients with disabling angina improved symptoms and exercise capacity

Hancke and Flytlie—69% of 253 patients improved EKG and exercise capacity, 91% of 207 patients on NTG stopped it, 58/65 on waiting list for Bypass avoided surgery

Metal Toxicity & ANGINAMetal Toxicity & ANGINA Casdorph 16/18 improved ejection

fractions Clarke 16/20 patients assymptomatic

after chelation Olszewer and Carter 844 patients,

77% marked improvement, 16% good improvement

Casdorph 16/18 improved ejection fractions

Clarke 16/20 patients assymptomatic after chelation

Olszewer and Carter 844 patients, 77% marked improvement, 16% good improvement

Metal Toxicity & AutismMetal Toxicity & AutismImportant Issues of: Blood Brain Barrier Protein Structure Total Mercury Reservoir

Important Issues of: Blood Brain Barrier Protein Structure Total Mercury Reservoir

Metal Toxicity & AutismMetal Toxicity & AutismRetrospective Study 31 patients with diagnosis: Autism Autism Like Spectrum Pervasive Developmental Delay

Retrospective Study 31 patients with diagnosis: Autism Autism Like Spectrum Pervasive Developmental Delay

Metal Toxicity & AutismMetal Toxicity & AutismKey To Success - Protocol Trans Dermal DMPS (TD-DMPS) 4 : 1 Ratio of GSH : DMPS Conjugated with amino acids, Delivered in a micro-encapsulated

liposomal phospholipid base

Key To Success - Protocol Trans Dermal DMPS (TD-DMPS) 4 : 1 Ratio of GSH : DMPS Conjugated with amino acids, Delivered in a micro-encapsulated

liposomal phospholipid base

Metal Toxicity & AutismMetal Toxicity & AutismRetrospective Study Baseline 2 months 4 months 6 months

Retrospective Study Baseline 2 months 4 months 6 months

8 months 10 months 12 months then 4 months

8 months 10 months 12 months then 4 months

Metal Toxicity & AutismMetal Toxicity & AutismRetrospective Study All 31 patients tested: Urine Metal Toxicity & Essentials Hair Metal Toxicity & Essentials RBC Metal Toxicity Fecal Metal Toxicity

Retrospective Study All 31 patients tested: Urine Metal Toxicity & Essentials Hair Metal Toxicity & Essentials RBC Metal Toxicity Fecal Metal Toxicity

Metal Toxicity & AutismMetal Toxicity & AutismRetrospective Study All 31 patients showed LITTLE or

NO level of mercury on initial baseline test results

Retrospective Study All 31 patients showed LITTLE or

NO level of mercury on initial baseline test results